<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D8F9</accession>
    <name>A0ABY7D8F9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WFS1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026209">
        <property type="entry name" value="Wolframin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13098">
        <property type="entry name" value="WOLFRAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13098:SF3">
        <property type="entry name" value="WOLFRAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02060">
        <property type="entry name" value="WOLFFAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ93967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="306" mass="34393" checksum="DDA85DA2B9522FB3" modified="2025-10-08" version="1">MPRIKDDNKEDVIWCVSNSNVEKTIRYAARALFLKINTTDKDVISIKEYTDAVKKLPKGHEKRLLIAAGKKMGDTISETEFVKLMSQQIQGTVTLTDSERSAAFQAATAVSGEFALEYASRNGLRMVFGCIPVDQINFLILFFISGYISKTFLQFILPLGMFYISYATIIITTIQILHKKMKLKESSDFAKMLHHYYDRVDVDQTQSQYAWNSLPLYLGYLVAMCCVVTSFSLADKMYIPCSELCVLNSVICGICFVYISDSHAHLYAGLTLNVGIPSICYSLIPVFFIQMARESGVSRCASDNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D8S1</accession>
    <name>A0ABY7D8S1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EMIL2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_005962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF50">
        <property type="entry name" value="COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="C1q" evidence="3">
        <location>
            <begin position="52"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ93491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="190" mass="21467" checksum="1063EC6AEE7CEB55" modified="2025-10-08" version="1">MIRMEFEHELWEKRINETIGNMVKLRTDIQNDLNELTRNKEDFDKHINATITQHPTVLFRARNVVDYSLSTTDQTIIFNEVLYNVGGGYNSPTGTFTAPVKGSYLFTVNLCPAKNKSIFYAIMVKEDVVVNGHTYNVSGWLCVSGEAIVQLDANDVVYVKSMYTSDVLLESGLLNSFDPKANSFSGVFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCV2</accession>
    <name>A0ABY7DCV2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TRI56-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_006636</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ94165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="448" mass="50864" checksum="744B3B49BE222E15" modified="2025-10-08" version="1">MFSEEGSLQEHEKIERLRDRMLQCPICMDEYRDPRILPCHHSICLSCLLDYVHASSSAGRLFRCPQCRADVCVPRGGVKDFPPNFYINCIQDEIGSRPYFGICEVCTRDWLISQYRCIDCDLDICKFCVHEHKLFKHLNGRQSNIIKIETGNVGFNMTSDKFCSHHKEETLQMYCLTCDAAICVTCIFEDHKKHSTMTLAKKLQLARKNLQFDLDNLQIEIKGVKSALTEVHEIEKNGDKSADEAIKAIQEHSQNVIRRIEEQAESKIKQIKDERGGHLKEIQDYAKDLSSHLDQLQRGASFLGDLQEEDMCLELLSCFLKYRQVIDAGETSIINKSIRQNQFTFTPGQIRGKLGHIWLARSVLKNQEVKKVLMEKKGAKVSRLRTCLAWVSMSGLLMVLMWVCVLLGVCQLVASMYSEGASAQGLACAGLYAYLCAAGICACWKARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DD77</accession>
    <name>A0ABY7DD77_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Solute carrier family 40 member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_007477</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in iron transport and iron homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17480">
        <property type="entry name" value="MFS_SLC40A1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009716">
        <property type="entry name" value="Ferroportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660:SF57">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06963">
        <property type="entry name" value="FPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ95006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="501" mass="55837" checksum="D4A9D9DD28BC3E63" modified="2025-10-08" version="1">MAEQEALDTSEQSVAVWYVYISHFLSAWGDRMWQFGVGLFLVIIAPDSLLLTAIYGFAMGAAILLLGPIVGDWVDKTSRLSAARISLVIQNLSITLCAVVVYFVIVYKEEIETEWPDRGLETLCYAVIIFIAIMTFASTEIGALFIGGWNLVSVVVEYWLLWKVYSVVPALRAQKDFCDKAVEKEEVKENKCSRCASGMLEGVLILGRGWKTFMKYDVAFAGLGLATLYMTVLGFDNVTVGFAYTQGVNESIMGGLMAAGALVGILGTIIYPYMRKCIGLQRTGLFALFMQNVFLTLCVVSVWMPGSPFDVNFKSKQQEDSGIITNETEINATTLPPLFNLSTTSMYNVTDTTEKTWEDYISVGMLMFGIIAARCGLWIADLTITQLFLETVVESERGIVFGVQTALNQLMDMLKFALVIIAPEPELFGILVILSYVFVTAGYVLYAKYSYSARGHILPHFGKIRFKEIAGYVHFNNTLLPRDDFIRYHSAHYGYGHETDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDK4</accession>
    <name>A0ABY7DDK4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cleavage and polyadenylation specificity factor subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_028402</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18345">
        <property type="entry name" value="zf_CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="12">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAQ95712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="173" mass="19835" checksum="74DB762FB71E14E7" modified="2025-10-08" version="1">MQDVVAPVQNITFDIEIALNNQLGAQPLPFPGMDTCPFRHVKGEKTVVCKHWLRGLCKKGDDCEFLHEFDMTKMPECFFFSKYGQCNNKECPFLHIDPAQKMKDCAWSKLQESSCEKIDLPELSIPTYDLPVPDQNIQTKKMMVVCHSCGEIGHKSISCPKMWREGPLCQQMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DE06</accession>
    <name>A0ABY7DE06_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P4HA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_028204</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046251006" evidence="7">
        <location>
            <begin position="19"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="8">
        <location>
            <begin position="328"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ95514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="531" mass="61444" checksum="A4C636FD48EFE853" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DE29</accession>
    <name>A0ABY7DE29_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATS20-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_007140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF281">
        <property type="entry name" value="PAPILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ94669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="309" mass="34937" checksum="1EAF7B6CF6493A41" modified="2025-10-08" version="1" fragment="single">MNETFNTAPIDGGWSKYEDNFTSCTATCGGGVKLKYRYCNNPVPQYGGRDCSGPSFIAKICNVVPCNYAPAVQDLCQKLNKVLPYSAKGQWHMDQNDPQRMGDEGCKYVCKTNNSDKPNYAVKLPYPDGRTCTHMNLNPLSRYYWGERKSTCSRSCGGGLRPHNITCMDGFMFNIKAEDYLCDIRTKPNEEPTPCNEHPCPYRWSTGNWSECSITCGHGLKTRDINCLQFQDGVHYVVPDILCASERRPDNQMSCDLGRCWKWHIKHESSCSKTCSEGFKNRTIICVEADTLLELSIDQCDEEKKPSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIG0</accession>
    <name>A0ABY7DIG0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CASP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_028964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1470">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454">
        <property type="entry name" value="CASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454:SF210">
        <property type="entry name" value="CASPASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14A caspase catalytic" evidence="2">
        <location>
            <begin position="50"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ96274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="299" mass="33688" checksum="A60FE311A3BAA013" modified="2025-10-08" version="1">MAVSEIVRNMEDKYYKTGKVYVAVFLNKRKQNPNASLKVPIECSDEEDVDLNIIRNLCKTKFGVDIEDEIVRNNNKDEILKKLKAFSETRAKDFDCFLFFFLGFIGDSQGATDSQTYKSDDGFLPIDEIYNSVKKSSDMAGKPKVFAFQAGDTRLLPSTSMTKAIPYGKEVEPKTKKIPTDADMLIITSTIPQLLANTNHERFQTYTGFAPKATTSVQPSDAVRGSFLIQAFVDSVLDESNRDADILTLTTVMNGKIEDLIEDVKKDERFDDKINQQILDKLELPLTTSTLTKLVVFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIK0</accession>
    <name>A0ABY7DIK0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="135" mass="15552" checksum="E13A323C02BED2FF" modified="2025-10-08" version="1">MGGVNLQSRFRIHRQKGRPVKNKAESSCEESDDEVVGRFACDLCPVNEKQYLKHVKEHEDPSQCVCKVCKFTVKRPSAMRSHMRIHEQEAAIRERMQHTQPDMASINKQMQHAQPDMTAVAEQMTSGQYYMADTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIU7</accession>
    <name>A0ABY7DIU7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_029818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="293" mass="32948" checksum="6AB8FC4E935CF3B5" modified="2025-10-08" version="1">MGWTCCATSSIAFTFTGLFLMAVGFSIPFWLSYSQPVTENGATRTYNLYMGTWYLMACEKGESNSCSSEPIEPKFNSRLNSLGWDFNGTTAETLAKSGANALGIPSLAISILQPILIALVFSIPGYSVTAETFPWSVLLFGFGSLISIIAAIMVLVVSCKWRDYGEYREQDKESISEDERPVSPSGIEMMSRSQPNYDRPRLPPSNGQRNGYDRRPDYGGFSKSKKYRDPYDDRSRDRDYGRSLDRGSRNQGYEGYDRGHYPPPSYEKSDTGGNSLSASRQDNMYRPYSQYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIZ7</accession>
    <name>A0ABY7DIZ7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ97677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="101" mass="11528" checksum="11F7446283A17728" modified="2025-10-08" version="1">MIPVLYNNILGSTNLKPPPFITKHPPRVLERDGDIKKRKEVLDGVLMKTDNCHVEAHKLIFAPDRSNITMQDIIVLLCSEFLVLHLRKSKITKLYSAYSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJ67</accession>
    <name>A0ABY7DJ67_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_022125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ97752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="455" mass="52619" checksum="DDFC486A97C255F6" modified="2025-10-08" version="1" fragment="single">MPRYPCNETSFCYTQEMMEAGIVTSFFRSCSLTKRDVKCEQIGPRLQNDISCQGELCNDVIKPHLRCGHSTCAYIRRNPDEWSKEDCIYKPEVMPRYPCNETSFCYTHEMVEAGIVTSFFRSCSLTKRDVKCEQIGQRLQNDISCQGELCNDVIKPHLRCGHQYNSAIRSTNTLKALLDEFIRQAPPWPVQTHTEKVNCQTVETVNSWRHGYAGIYGQVNYWRHGYAGANGQVNYWRYGYAVVNGQVNYWRHGYAGVNGQVNSWRHWYAGVYGQVNSWRHGYAGIYGQVNYWRHGYAGANAQVNYWRYGYAVVNGQVNYWCHGYAGVYGQVNSWRHWYAGVNGQVNNWRHGYAGVYGQVNYWRHWYAGVYGQVNSWCHGYAGVYGQVNYWRHGYAGVNGQVNYWRHGYAGVYGQVNSWRHGYAGVYGQVNSWRHGYAGVYGQDNYWRHGYAGVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJG7</accession>
    <name>A0ABY7DJG7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="247" mass="27964" checksum="9E5635B2FD317CCB" modified="2025-10-08" version="1">MEDRNTLTLTGKQKPTLTLNGRQKPRVTLNGRQKPTVTLNGRQKPILTLDGRQKPTLTFNGRQKPTTEATLTLNGRQKPTVTLNGIQKPTLALTGRQKPTLTFNGSQKPTLAFNGRKKPTLTFNGRQKPTPMSNGMEDTLTLNGREKPTLTFNIETHTDVQLKTETHTDVQWKTETHTYVQWKTETHTDVKWKTEAHTDVDWKTETHSDVEWKTETTLTLNGKKKPTVTLNGQKKPTLTLNGRLKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJQ0</accession>
    <name>A0ABY7DJQ0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_029521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21421">
        <property type="entry name" value="GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21421:SF29">
        <property type="entry name" value="GUSTATORY RECEPTOR 5A FOR TREHALOSE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ96831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="58790" checksum="AA697F8EF60A2716" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKI4</accession>
    <name>A0ABY7DKI4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FADD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_030141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd08336">
        <property type="entry name" value="DED_FADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169:SF7">
        <property type="entry name" value="CASPASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169">
        <property type="entry name" value="DED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01335">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DED" evidence="3">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="161"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ97451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27993" checksum="5775832E5B36D285" modified="2025-10-08" version="1">MADQLEKYRDVLLEISHCIDENDLSKMKFVSLDKIKKKQSEKILNPLQFFTALEERGFLGQNNLSYLKNLLQKCCAGKVNGLRILELYEQGLIQGIPLYDTPQGATFNLPGPGVPNGGHPGQSQVIYVVHEPGRVPDGNLNGRQERQIYNGPDLSEETDFLTNNLGRDWKFYMRALGIHDNDIDSVSHDYTSMRERIRQCLLLWQQEQQQNANRIKLINACKHSSVRRMDLACKIEDGSFRNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMR2</accession>
    <name>A0ABY7DMR2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CBPA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_028980</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF153">
        <property type="entry name" value="ZINC CARBOXYPEPTIDASE A 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047155285" evidence="12">
        <location>
            <begin position="19"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="13">
        <location>
            <begin position="115"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAQ96290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="391" mass="43523" checksum="67FC951B2FD3AEDC" modified="2025-10-08" version="1">MMDLHFIIFLGLSAVGAAKNYDGYQVFKIQPEAEGQLEKLCELLKDMRLDVWKEGVIGQETHVMVNPELIKTFLHKMEKNDLQADVMISDVGALERAEREAMKQGSESASFDYSTYHSLAEIEAWMTDFAANAPPGIDVTKIKIGESFQGRDLSLLKVERNPSATKPNIIMIFGSHGREWISPATALNFLNYLVSEASSLNTYSWHIVPVINPDSYYRTTDAAGEEKDRLWRKTVSSHNEKAGPDCSSQTFSGLEPWSETEVQAIRDYVISTNVAAFVDIHSYGEIVLLPYAYTTTRVPHFDELMELGTISASAIESIDGHTYAVGQIPDLLAMAHGLAMDWTCKDEHILISLAYALRDKGEFGFLLPRDQIQIAGEEFIAGVMAMVNGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMS4</accession>
    <name>A0ABY7DMS4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LIN10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_023372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd06720">
        <property type="entry name" value="PDZ1_APBA1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06793">
        <property type="entry name" value="PDZ2_APBA1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051230">
        <property type="entry name" value="APP-Binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345">
        <property type="entry name" value="SYNTENIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345:SF16">
        <property type="entry name" value="X11L, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="61"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="152"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ98999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="242" mass="26248" checksum="E1832F04B41B0F14" modified="2025-10-08" version="1" fragment="single">AQLIAQSIGQAFQVAYMEFLKANGIEDQGLLKEIDYQEVLNQQQIYGEELSMFSNKENQKEVIVPKVKGEQLGVVIVESGWGSMVPTVVLANMSPTGPSARCGQLNIGDQIISVNGISLVGLPLSACQSNIKGTRHQTVVKLTVVPCPPVVEVLIKRPDVKYQLGFSVQNGVICSLLRGGIAERGGVRVGHRIIEINNQSVVAVPHEKIVSLLANSVGEIHMKTMPTSIFRLLTGQETPHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSG0</accession>
    <name>A0ABY7DSG0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">POL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_023401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd03714">
        <property type="entry name" value="RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="254"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ99028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="482" mass="55251" checksum="E243C9776C2FF1AF" modified="2025-10-08" version="1">MPKLKAPEMGEPVINQEIWKIMNIGGHLNDKLMVDIQNLVADGIGLVLKLVNLLKDQSLGTEAKGVLSDTLTILGQTQYNLSMRRRYMIRPALKKKYAGLCNLSTEVTKKLFGDHIDKEIKSCETLSSIGKDSYPQRGTFARGCGRFQQRRGGYGSTSHMSSTGQEALALGGVRGLGRIPKCYGHSHKRSMESSVGKLKLYVDQWKNYTNDSWIINAVSGYKIYFVKQPYQEKVPNEIPFDGEKWEIVNDEIRAQLLKLLNESEEFISTLFIVPKPNNKFRPVINLRFLNKFVGYNHFKQEIFNVVLDLVQRNDFFTKMDLLEAYFSVPIHDDSTKYLKFSWNGLLYKFICLPFGLAIAPFLFTKILKPIYAWFRKQSVRCSYYIDDSLNMNQDKLICSRNTEMMTDTLESLGFVLNREKSVLKPCQRILFFGFILDSVEFKAKTLLSEGVVVIRDLASFIGLLVNAFYAVFEAKLHFRDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSM2</accession>
    <name>A0ABY7DSM2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="6">PARP</shortName>
            <ecNumber evidence="6">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_022328</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="6"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF67">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Macro" evidence="9">
        <location>
            <begin position="700"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="8">
        <location>
            <begin position="1031"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="879"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="879"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="909"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="924"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAQ97955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1296" mass="146343" checksum="805916861AB8E883" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUN8</accession>
    <name>A0ABY7DUN8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CF161-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055325">
        <property type="entry name" value="CF161"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24274">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24274:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24569">
        <property type="entry name" value="CFAP161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="287" mass="32501" checksum="B242274391418100" modified="2025-10-08" version="1">MSVRTYNPSVRVGNWNEDIQLEEKRESGELLYQKRTKLEQTIFKTVNLSISRDGFVHFGDKVNIRCPGALDKTQYFAHIEPRNECNLAVVPQVNKILYSNKFEAPSCVTGSRDIASNLRSTFVIKSKDGTHDGEPLRYGQVFYLSTMDNEGGNLLLQSDRVTLHKSPNKSRHQEVSLVAEPSSLTEWKILHFKPKLRFEYEGVPVPANEKIIFNHVVTNQDLCVEEEVAIRTSFGTREYEITACTQLDSHRAEKEQNQWMIVMGVPGDDIYPVSQPSCSSQGASSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZ00</accession>
    <name>A0ABY7DZ00_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_009533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR02975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="191" mass="22201" checksum="0D7D6C6871B4C132" modified="2025-10-08" version="1">MGNHSLSYATKVYFYPVLHSVPHTPCAKRPLRCVCTAILYDRVKMVKSRSEICKDYRKRLKETDDETYLRKERERGRKNYVPSAALSTAERAVRRYKVRKAVKRCRQKKKQIALERDRTAQSESLNTSGYDSVGGSAENSENLVVAMQFPNRAVGPRNRVTQELKRANQQLKELKMAHLNLTRKLKTEQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZ65</accession>
    <name>A0ABY7DZ65_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046251014" evidence="1">
        <location>
            <begin position="19"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="482" mass="52496" checksum="E3BE5D5C8B84C11F" modified="2025-10-08" version="1" fragment="single">MKVYSVVVFLCVASLARAMTLRLELETTALDDLVKPFLGLNGDWTCSSGTCKKCETVQGRTEKNPGQICKDTYGYKVCLQATKVDLQTGSACLEFSVTAQGQIHKMPYGCFTLKQKPASSELAFQVKNFAENMLGLNGDWTCSSGTCKKCETQQGQTACVVATSPVANTIHIQVETSGMVLFNADIKEKNPGQICEDMYGYKVCLQATKVDLQTGSACLEFSVTAQGQIHKMPYGCFTLKQKPASSELAFQVKNFAENMLGLNGDWTCSSGTCKKCETQQGQTEKNPGQICEDMYGYKVCLQATKVDLQTGSACLEFSVTAQGQIHKMPYGCFTLKQKPASSELAFQVKNFAENMLGLNGDWTCSSGTCKKCETQQGQTACVVATSPVANTIHIQVETSGMVLFNADIKEKNPGQICEDMYGYKVCLQATKVDLQTGSACLEFSVTAQGQIHKMPYGCFTLKQKPVSSELVFQVENNAENML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZZ0</accession>
    <name>A0ABY7DZZ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MO25-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="312" mass="36506" checksum="9A7B846795A3CDEA" modified="2025-10-08" version="1">MPFTVFGKSQKSPQELVRSLRDALSALKKETGEKKLDKASDDVSKNLAQIKTVLYGTESQEPQSDQVAQLAHEMYDNNMLYMLVQNLAKIDFEGRKDVAQIFNNLLRRQIGTRAPTSQEIALNCGMMLRECCRYEQLAKIMLHDEQFFNFFTYVEVSTFDVASDAFSTFKELLTKHKMLAATFLEQNYDRVFEPYQHLLNSENYLLGELLLDRHNFTIMTRYISNPDNLKMMMNMLREKSRNIQFEAFHVFKVFVANPNKPKPILDILLRNKDKLVDFLTKFHTDRSDDEQFNDEKAYLIKQIKELKSTDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0W0</accession>
    <name>A0ABY7E0W0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_008704</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd05599">
        <property type="entry name" value="STKc_NDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="302"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR02146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="341" mass="39688" checksum="A29D49D76249545E" modified="2025-10-08" version="1">MEEDGLNDEQKSQKRQQHAVKETEFLRLKRSRLGVEDFEPLKVIGKGAFGEVAHVRAERDVLVEADHEWVVKMYYSFQDNVNLYLIMEFLPGGDMMTLLMKKDTLTEEQTQFYIAESILAIDSIHNLGFIHRDIKPDNLLLDSRGHIKLSDFGLCTGLKKSHRTEFYKDLHHGKTGDFNLNPMDSKRRMESWKKNRRALAYSTVGTPDYIAPEVFMQTGYSSSCDWWSLGVIMYEMLIGYPPFCSENPQETYKKVMNWMETLIFPPEIPISTEAKDLIQKLCCDPEHRLSSREQIQAQSFFRGCDWEHIRDRPAAIPVDIKSIDDTSNFDEFPDVDLKWPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1H6</accession>
    <name>A0ABY7E1H6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_010405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35836">
        <property type="entry name" value="VCBS REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35836:SF1">
        <property type="entry name" value="VCBS REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047391096" evidence="2">
        <location>
            <begin position="26"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR03847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="446" mass="48410" checksum="D59FC7060FB3A511" modified="2025-10-08" version="1">MAGTLVGMFQVRFLCFLAVCRLGHGATLQRLGSFSAKSPAFSTLYEEARPATPGDRYSLIVSTFSGPTLFSSSVDSVQLVRSVGAKLGNIGAITPEVVTKDVTWPNEISIVPDGVFNEKMLAIPDGFLVPFKTNGAVKLVDISTPGSSQGPYVLTDHSSGDWFYHRVEWHDMDGDGDQDIVTCRAREPVVPVIFGREDEELVWLENPGGNFRHTWTSHVLTHGPDVYFRFTRMATPDGMKECIFTAQFFTESISVYWTSDSSGLFTDTKQLQSRVIDASIGRVFEVDVADLNGDGRPDLLVTTNGNNGTLLAYEIPDDFRQTTLAFVKHTIAVGFSPRSKSIGKGAPGSAIAVHPQPAKNTSKPVILLSGDDDGRAYVFEAASQDPAAWAYNKQVFFDAGDATVGELSAADVDNDGYTDVFVPSFNGNEVIVYSFRPALSDQNILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1W3</accession>
    <name>A0ABY7E1W3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_009371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR02813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="402" mass="45517" checksum="7D1ABFFD4C8B84EF" modified="2025-10-08" version="1">MERQIINEKLLKLKSESQLSDNDDDDELQLSQILPGQQDPQQLSQYRQYLWDRVRGSSGCPSGHLKSRKSTNKSSKFAKLASDCYVLQHFIDGERTSEIHDIVSSNVLLNDSLSITRDVDTDDGHTASGCLKELDVLATLLKLQADVDDLKFQQKKSTDLFSDVKERLTKVFSFQDILISSINGIRARLPTQDVLNGLGSRKYMNGTGFHHIMPGVRLPFQCVVCKTRTNPKNRRKINSELKQLILKRLPIELKDTDVLCNKCRIKHFYKLSPVENFDNKLIDQSDNEEYQPPISKKTSFASPPSVRLNIPSTPKSHSRCFICKRPGPKLIVVPSEARFTAFVQRNVIIKSGTRCCPVHMDESQIKDEALQSVKASESAFVNRATVLELLNKLRASCNKTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1X1</accession>
    <name>A0ABY7E1X1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase</fullName>
            <ecNumber evidence="3">3.2.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_010383</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16301"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="EC" id="3.2.2.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16302"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARM1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.6" evidence="3"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd09502">
        <property type="entry name" value="SAM_SARM1-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24153">
        <property type="entry name" value="SARM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039184">
        <property type="entry name" value="SARM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998:SF1">
        <property type="entry name" value="NAD(+) HYDROLASE SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998">
        <property type="entry name" value="SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="516"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="591"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="12">
        <location>
            <begin position="673"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="909"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="918"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR03825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="978" mass="109771" checksum="D31966EAD2AA5736" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1Z1</accession>
    <name>A0ABY7E1Z1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FBX40-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_009534</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.150">
        <property type="entry name" value="TRAF-like zinc-finger, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031890">
        <property type="entry name" value="Fbxo30/Fbxo40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043013">
        <property type="entry name" value="Znf_TRAF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15933:SF20">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15933">
        <property type="entry name" value="PROTEIN CBG16327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15966">
        <property type="entry name" value="F-box_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15965">
        <property type="entry name" value="zf-TRAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRAF-type" evidence="7">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="8">
        <location>
            <begin position="477"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="5">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR02976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="652" mass="73889" checksum="94D0056CB3370232" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2F2</accession>
    <name>A0ABY7E2F2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RAD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_009551</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003011">
        <property type="entry name" value="Cell_cycle_checkpoint_Rad1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01246">
        <property type="entry name" value="RAD1REPAIR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR02993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="283" mass="31402" checksum="825F8AB02F3D4686" modified="2025-10-08" version="1">MPMSLSTQEPADDDQFLMIAKIDNARSVSNILKAIHFKETATVFASSMGLKVTVEDAKCIQANAFIQEGIFQEYAIKEDQLTFKINLTVLLECLTIFGSGPVGGACTSLKMCYQGYGCPLILILEEDGVLTDCSIKTLEPDEVLDFNFCSTNVVNKIIMKSECLKEAFNELDMTSDVLEFLMSPDAPHLRLSTFGNAGSTTSDFPKDSDMVESFQCSQTQTNRYKVSLLKPSVKALALSSRVSIRTDNRGFLSLQYMIKNEDGQVCFVEYYCAPDEDLDDPDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4I0</accession>
    <name>A0ABY7E4I0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="189" mass="21067" checksum="C095698A58D50941" modified="2025-10-08" version="1">MNASQGDVQHEKRRAQEFEAKYRELVKKAKSEFYKLEQANLKYKNDAKVSQDIISDKENEICVVRKELEQAESLSKNLNSKLKETKSAFEKALQDKEILQKALCSSRETLNGSGGSPEEETSAFCMKQSQRQLARIKSAVIASDDKDSSLPVLVSKQLGDCRKAVAETSGKNMIQVDNTIFGSSTLIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5I2</accession>
    <name>A0ABY7E5I2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FACT complex subunit SSRP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_008969</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="10">
        <location>
            <begin position="338"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR02411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="400" mass="45592" checksum="2BE40B281CF4DD8A" modified="2025-10-08" version="1">MSDYQEYPDIVQEVRGALNPGRLKLQGNSIVFRNQKTGRSDQFHGTDIEKVQWLKRARGYCLKILLHSGHIHRFDGFKESDQEKLSSFVSRNYDVKLEPVDLSVKGWNWGQAKFEGNGLNFLIDNNLAFEIPLNNVCQATPAKSEITLEFHQNDDAAVSLMELRFHIPPDQNNQESDNVSEFYDQVMKNADIIQATGDAVCVFPEVQCLTPRGRYDIKMYTTYLQFHGKTFDYKIPYTSVLRLFLLPHKDGRQIFFVVSLDPPIKQGQTRYHFLILLFSKDDEMTLECGLGDELEERYEGKLQKEMTGLEYEIVSKVFKAVTTRKITVPGSFIGHSGSPAIGCSYKAATGLLYPLERGFIFVHKPPVHIRFDEVAAVNFGRSSGSNRSFDFDVETKAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6N5</accession>
    <name>A0ABY7E6N5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HARB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_019965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF135">
        <property type="entry name" value="SI:DKEY-77F5.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="4">
        <location>
            <begin position="34"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="5">
        <location>
            <begin position="272"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="4">
        <location>
            <begin position="539"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR04596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="730" mass="83632" checksum="0081AE109308757C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E720</accession>
    <name>A0ABY7E720_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BCAM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_021209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="121"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="204"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="293"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR05840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="387" mass="41949" checksum="7FBB7822BFB705D4" modified="2025-10-08" version="1">MLFYTHIFYFTVNCQECERLVSLPAKQPVLRYEFNFSIPDVYVQLENPNGTPIFQAFCTSTTCQSAEYINSTLDPSGDIATGKFHIKLNSFGGGQQGNYTLWTEGRKTFLKCIKLYLLGKPRPSNIIANRVPYEGEAVILTCHSISTTDPPGHDLVMSYTWTEDGTMLTSGGRFTLLPNTAATLTITKVQQSDELSQFACTDGPDNIAFNSTGISQAVSEGDSFPPVACLADCKPSCIFRWTKDQSSVSTSAVLDLGIVGSDDMGIYTCTGTHSVYTTYTDTKTYSVTVTYGPNNVSISPSTTSYTTTEGDSQGEITCSAVCNPECAYTWSKVGATGTLTRQEAGSYICSASNPSSSTTRTGPIVVVEVICKSNNSIHLYNIESISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBN7</accession>
    <name>A0ABY7EBN7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RB87F-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_021576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="27"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="119"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR06207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="373" mass="38001" checksum="9545944ADFB1A381" modified="2025-10-08" version="1">MYLGGGYGGGGGNDADYYQNPNAENFCKLFLGGLAPETTEDSIKDHFGSYGNIVDCVVMRDPEKKRSRGFGFVTFDQSSAVTDVQGNRPHKIDGKNVETKRATPKSQQAEGQDAKVTTKKLFVGGIKDDMTEDAIREEFSKFGNVTSIKIIQGKGFGFIEFDDNDAVDWCNLIGKFNICDKWVNAKKAQEKNKQDQRGGGYGQQGGYGSQGGYGGGSYGGGGGYGDSYSSGGYGGDSYGSGGFGQDYGNSYGGGAMKSSSYGQTRQQPYSGGESTTGGYGSQSYGGGGGGGYGSGGGGGGSYGSGGGGGYDSSYSSGGYGGGAGGGGGGYSGGGGGGVETAAENLLVGTDQTVKGAYDRRPKFKARSTQADDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDB7</accession>
    <name>A0ABY7EDB7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IST1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Charged multivesicular body protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_016679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation. Is required for efficient abscission during cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2. Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with CHMP1A, CHMP1B, VPS4A and VTA1. Interacts with SPAST, STAMBP, and USP8. May interact with VPS37B. May associate with the ESCRT-I complex. Interacts with MITD1, in competition with VSP4. Interacts with SPART (via MIT domain); leading to the recruitment of SPART to midbodies. Interacts with SPAST.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR06721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="402" mass="43819" checksum="0A56E722DD2018F2" modified="2025-10-08" version="1">MFSSSTNYNKLKTNLRLTINRLKLLEKKKTEIGQKARKEIADYISSAKDDRARIRVEHIIREDYIVEAMELLEMYCDLLLARFGLVQTQKELDPGLEEAISSLIWAAPRLQTDVPEMKTIADQLTIKYGKEFGQACRTNALNNVSEKVMHKLGVQAPPKILIERYMIEIAKSYNVPFEADPTVMSQDEIFAAENLLIDLDENRKPGGGAGGGGGGTGILQPYPAQPQEGYKSAPPPVPNTPPSGYAGYPPGGASGGLSPSAPAGGQEHSPPPPYTSSHTSPMPSQNNMDSFPDLPAVPNSTLPDPPGASSAGGEDVDFDDLSRRFEELKRKKCLPVAAPLPDLIWIEEPRLVAVGTGVGVDLLFPRPIPERLVFVKLSASHFIPHILSNFGYVVDPLARQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDU8</accession>
    <name>A0ABY7EDU8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HMCN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_018155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF21">
        <property type="entry name" value="SEMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C1q" evidence="3">
        <location>
            <begin position="168"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR08197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="340" mass="36655" checksum="585298ED1FA3AF39" modified="2025-10-08" version="1">MTCVLGFILGNNGTQVDGAWSFWSSWGQCDVTCGNGTRSRVRTCDNPAPAHGGNVCPGDRDQTITCIVNQCPDLLTQNIIYFKVGWMTWSDWSSCNEACGLGQRQRSRSCQNPLASLINNSCSGNAEETQICSSSSCTLGWTSWSGWTSCSVACGTGLQKRSRSCQNPMTSLINDSCSGSSAFTATGYAPYGPYSIRFPSVILNEGNDYNSATGVFTCRVPGLYLVTATIGKEFGTSVEYVPCYIQLNGSDKLYLYHDPNSDEQDGYTSSATGTFRLHSGWRSSSVYDCTAVLSGSKGRFSGLSESACSSSPYDDRMPAPYALCSPFCLQIPNSIVNQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EE69</accession>
    <name>A0ABY7EE69_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Wee1-like protein kinase</fullName>
            <ecNumber evidence="11">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_018133</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="11"/>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017164">
        <property type="entry name" value="Wee1-like_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF185">
        <property type="entry name" value="WEE1-LIKE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037281">
        <property type="entry name" value="Wee1-like_protein_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="230"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="102"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR08175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="572" mass="64764" checksum="20D0FF0B776D3569" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEQ3</accession>
    <name>A0ABY7EEQ3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="91" mass="10104" checksum="57B03266DCCBCDC4" modified="2025-10-08" version="1" fragment="single">TSSDDGVLHITTGGVQYAVVHRQADAQRTETLQPHDEAGLTYADLDIKFLQEANARVPVRRKNKPTEYADIDFSSTQETAVEDPVYHFVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJT0</accession>
    <name>A0ABY7EJT0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="467" mass="52569" checksum="6EB8A40143DB226F" modified="2025-10-08" version="1" fragment="single">MSYSELVGGDCARFTTYQDLVQLEHVDDCTNIDDAFKWVHRLNDLHPDCIKRALTQLSGKEYFQTELKIHRQRICEKHKQSKSTILGLSSTFYLTFESQSAFALNKIKLLSIKYKNRIAAEFRNYHTIQVSTTSFTQTTGTTPRHFIAKDHITVDVSGILSSTAPDFLSDVDSTEYFQVMAVQSKKFADGKCPSCNKMPDTEQHNGSAMVILKKKDRFSQVRFFMDNLKKLFKVDDITDSNKLLQQLKTQVPVTARGRFTNTVWYNLSRVSTTVMAGYSPTTSCLIDIVYHLDYTQSQTLQTECSQISSYTVWGLLHHLELRNPSCRKTLVNNMYVTGNLDGCRGHDNDYGKLINNLFEQVENAEHTCDPHKVITILAHAQIVTHPDAHPCSDVQVGTNEDLVLNACNLTAPTTWTRGVNVITICSSIPKYTPIASFQSSTGYSYHAEGGEQSGVLLECDTDGNGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EK19</accession>
    <name>A0ABY7EK19_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="9" mass="1130" checksum="3C03B3733452C047" modified="2025-10-08" version="1">MPIVNKWDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKZ1</accession>
    <name>A0ABY7EKZ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_034870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14291">
        <property type="entry name" value="UBA1_NUB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14298">
        <property type="entry name" value="UBA2_scUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039749">
        <property type="entry name" value="NUB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033864">
        <property type="entry name" value="UBA2_scUBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12948:SF3">
        <property type="entry name" value="NEDD8 ULTIMATE BUSTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12948">
        <property type="entry name" value="NEDD8 ULTIMATE BUSTER-1 BS4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="36"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="225"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="281"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR09794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="388" mass="42936" checksum="F0AD2D6EE89EAC0A" modified="2025-10-08" version="1">MADEDFMKKRLASFLNRDKVKLWEEPFTNKDGSAGNIPQTSKQPLSLEIKLLEQGKQLRDQVSDLIHHPGDQMKLICSGLVLKDDLTLQQQNVRVKYDEMDIQIADQTGKPIQLPAGEKKALTLAIALHEKGRQAQCRADILNSVDNYAILCLDIGSTGEELALFMKLHLLQGIVAYHQDRMSEAAQLLGRAESELQRLTIDEDKLNAVMTMGFSEGEARLGLRAVKVESYEMLIGMGYPKGAAAEALRQANNDLNLSLEVLQNHPEYLSLPDPVPKRKVRITDEMIAQVTSMGFEPEMAKWALQKNEGNVGKAIEDLIESGGSIQSPLDDEQPGTSGSSDNCPTVCLPLTVNEKSVEITLVRVFNLAHIGDSPPEACDPDDTNRRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELJ8</accession>
    <name>A0ABY7ELJ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MT21A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046487147" evidence="1">
        <location>
            <begin position="34"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="230" mass="26420" checksum="530A9234DDB4E47D" modified="2025-10-08" version="1">MFVMQVERNALISKRAVAVLLIVYTFLLQCIQAEYCDTRSEDKNTEVNTGQCIDTNTMALMVYNENDVLPLHRQERKFNFASHDIIIKQDWKGLGVAAVVWDASHTEVVHDRSVIELGAGAGLVGMVTALLESLDRVSIQPLDWTKDLASFSQTFDVILGADIVYIEEVFEDLLKTLIKLSRKDTLILLSCRIRYDRDTRFLERLKEHFVVEKILYSDKMDVNLYKAIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMH3</accession>
    <name>A0ABY7EMH3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_036264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR11188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="314" mass="35365" checksum="E856FA3A6760C419" modified="2025-10-08" version="1">MDTIVNDISKQYGGPPIVFMRETKNAKKQEWLKHEELYEALADVIVCTHITGLQRVRGMWRIYVENIDDKVSLLTEGVTLRGKMIKLLNTNPNRLDGEQTVRIRVKDIPLSVDDSVILRSLVAENIDVITIIREKLRVKGKLTNCENGDRLCIVKSSSLSATLPKFMAFGHFTGRVFHPGQNSENKELKCRKCLETGHKMIDCENDWRCLDCHQIGHKKGECELESNPSSTPQPDIEVTQIQDSIQQAEHKEKAENAINGQKPIDAFVVIGADSQVTPNKGKKPIASERSPPTPAEVLNDESKKSRLKDCDTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENJ2</accession>
    <name>A0ABY7ENJ2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="79" mass="8851" checksum="95D0E9064E619137" modified="2025-10-08" version="1" fragment="single">MYWKDNKTSGLVKKTRKMGTQGNYTNCTVINEEGDSEQIEMKTYNFTGLSNKGTIVSLSREPCASNSTIQLTILPQDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENT5</accession>
    <name>A0ABY7ENT5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_035773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd10229">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR10697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="617" mass="70108" checksum="EAA5FDE1247858F2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EP56</accession>
    <name>A0ABY7EP56_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="75" mass="8625" checksum="B01254A6EDD9C738" modified="2025-10-08" version="1">MSCGCVVVENIDTSRLDCIPDPYMTREAFWQNVVLSLSGKNQKRQISFAVKKCRMELYADELYKNETRIDSDLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQL9</accession>
    <name>A0ABY7EQL9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZN407-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_026418</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="470"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="515"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="543"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="879"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="908"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="939"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="966"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="996"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1024"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1052"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="655"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1144"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1163"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1179"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR12238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1216" mass="141032" checksum="CF9E1C25F31CE6B4" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETB6</accession>
    <name>A0ABY7ETB6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="259" mass="29167" checksum="789121E312F2E41A" modified="2025-10-08" version="1">MLPNHPSPGNAFDSPATGTHKSKSALSRNKMKTKDPERYRIYLDKQKVKAKQRREELKRELQKKKGNEQSKAKKPHQNEMQRRRQKSPWTVADSIHGVSHFAQDCDNATVQIEVTDVTVPIDGTIETVILETLNETVSIESINTISNRKNKVDCSVKNINGTVPDKQTHDTIKIDETKLDGTSDTIIKESTNETGSLKSTNETVLNIEETDTIESTNETGSLKSTNETVLNTEETDMIESTNETVQIEIQKESSERMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETH6</accession>
    <name>A0ABY7ETH6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">STING-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_025884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12100">
        <property type="entry name" value="Stimulator of interferon genes protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029158">
        <property type="entry name" value="STING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038623">
        <property type="entry name" value="STING_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055432">
        <property type="entry name" value="STING_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34339">
        <property type="entry name" value="STIMULATOR OF INTERFERON GENES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34339:SF1">
        <property type="entry name" value="STIMULATOR OF INTERFERON GENES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15009">
        <property type="entry name" value="STING_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="15"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR11704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="447" mass="50651" checksum="66F88A2A813C1673" modified="2025-10-08" version="1">MSEVASSEQSRDVQYEFDVFLCHSGIDENITRQIHKSLTSQGLKCAAQFDSTTFPTGRPVLASIGWLVQNSRKTIVVLTRNALESSWISVETILALENSQERREQDLTLRLLLIDIDKRDVPMLKCGLLASIPHTATSLKRHNWDRDVINSLRTRISVSKFLPVGSLAHAMVFSHFTGLMFYMIKHCATTHFQILFDAVREQVMDHKDSDLKENKQMQETSLKATSSRGGVVQMEERMPCGDVATGLCWAYIINYLRHTLYNKDFKGRIQRFLEEKNMNCGFLTKMYIWWPRSCKAADSVVDGANIGAGEGSQAPVKKIDSLPEVIVDQGAQQKKPFILNVFQYTRPADGKIFCFVSEYCAAMGCLYQMAKNFAFAGISTEEMYRQGKVFVDKFVEISSRQAVKDQFGDFNECAKVVYYDDSKTNLLAAIENEIRQAEVDESAICYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETV3</accession>
    <name>A0ABY7ETV3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="1">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="290" mass="33161" checksum="03E8B25C797C2BCC" modified="2025-10-08" version="1" fragment="single">MADDDRIANACRNDTLDRCNVDELKKYLRSVGQYVSGNKSELIDRVKGAYKLGLGNVNDLQESDRSAFLRRENERLRTPIGGKMTHPSCIDSWSDDVSLIPDMTEKDIYNYFVYKLNTKCQLKSKVMYEDWHIHRVQAIPSMPSTNQKQCPDYDVWVMLSKMTGCINSAECSCTAGYDLTFQKVIHGKQSVIKKLSVPVFNIQKPVDVDKFKDKLLGMGANAGWLKNFEVKTDSILIPKLNEINFNFSDSVNLKDPKQTDFFNSYFKSMQITEFDCMTIECLTRSQGQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EV97</accession>
    <name>A0ABY7EV97_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KRIT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_026638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2240">
        <property type="entry name" value="KRIT, N-terminal Nudix domain, NPxY motif-rich region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051594">
        <property type="entry name" value="KRIT1/FRMD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057096">
        <property type="entry name" value="KRIT1_FRMD8_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032022">
        <property type="entry name" value="NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043058">
        <property type="entry name" value="NUDIX_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13283">
        <property type="entry name" value="KREV INTERACTION TRAPPED 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13283:SF11">
        <property type="entry name" value="KREV INTERACTION TRAPPED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24522">
        <property type="entry name" value="KRIT1_FRMD8_FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16705">
        <property type="entry name" value="NUDIX_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="310"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="3">
        <location>
            <begin position="387"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR12458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="711" mass="81259" checksum="6A06F943321C87C6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EYC2</accession>
    <name>A0ABY7EYC2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="73" mass="8209" checksum="295C911B2F5ABFFE" modified="2025-10-08" version="1">MNGIFPKKKVCSKAEVMLGLRSLRWLVAILQKVLDVAHNDERTILSCLDEDFPVMGPISRERSYAEDQCDGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EYF0</accession>
    <name>A0ABY7EYF0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="4 14">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MAR_003992</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="14">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="14">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="4 14"/>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="13 14" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="6 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="15">
        <location>
            <begin position="37"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="16">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAR13887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="257" mass="29209" checksum="672B06EE8D39C85C" modified="2025-10-08" version="1">MPARDLVKLLQPKSALMQLVQARCAQTAAATQPARMKKFSIYRFDPDKPGDKPRQQTYEVDLNQCGPMVLDALIKIKDTVDPTLTFRRSCREGICGSCSMNIGGENTLACLCKINDNSSTLKVYPLPHMYVIKDLVPDMANFYAQYESIEPYLKKKGITEEDIGKESYLQSVPDRAKLDGLYECILCACCSTSCPSYWWNSDKYLGPAVLMQAYRWMVDSRDDYTDERLAMMEDSYSVYRCHTIMNCTKTCPKPVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F027</accession>
    <name>A0ABY7F027_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="112" mass="12114" checksum="FDC74F62D1740F0F" modified="2025-10-08" version="1" fragment="single">LTATLPIHAQQQSRCVQLFDAGFRQCFRDLGGFELDIVFSLVTNETSSRLPPNLAPQKQNLIQMLCANRQQVGQCIGPLVTKTDPSCQQTDIGMMDGTVNSMVSGLANICGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0Y9</accession>
    <name>A0ABY7F0Y9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S66A2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_027211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR13031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="266" mass="30241" checksum="AF7D692158D2DE03" modified="2025-10-08" version="1">MVDIKKPVDQLIDSANEVQAAVSMNVALFTMPELTFASIASVVAAGAMIIGGVFPFIPQYRDIYRSQNADGFSLYVCLNLLIANILRILFGKHFELPLLAQSVIMTFTMMALVHLCVTVKHKTEIIRSRQHQFSDLDIEHFWQWTDFGSYVQFTAAFTVLMGLLTYLFLGNWVFIETIGFLAVFAEAMLGAPQFYRNFQNKSTQGMSKKMVGMWTMGDVFKTCYFVIREAPPQFWICGSLQVMIDISIFIQVFVYRRNFVPHAAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F145</accession>
    <name>A0ABY7F145_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_005407</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="4">
        <location>
            <begin position="150"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR15302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="299" mass="33362" checksum="6B87D0D2A5285746" modified="2025-10-08" version="1">MKTSDSTSATMTTTSLFAGTTASAGVPSSVTSTTNNHPASPVTTADGLDTGTPDLEVTFHPRHYRPGRLSLRQQRDKCTPCSSNSSKSVIEICDSEDEEMSRAIEASLNDSQSLRKEKNTTSIEQVLKEYRDGAVKKDFFRSRVLESTFRAITRKSFNPNGQLYVKFSGEMGEDYGGPRREFFRTLAETTEFTRGLNDVGHLWEVVTRHRELFKPIFCHKPTGLTKDVVYGLCKIEFSEPGKIEIMFYDQEDGVTRLPSVSTCGLQMWLPRGVGEPDTLSSFIQTDVKGFHKISCPNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2X7</accession>
    <name>A0ABY7F2X7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">STAUH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_030684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd19860">
        <property type="entry name" value="DSRM_STAU_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051740">
        <property type="entry name" value="DRBM-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032478">
        <property type="entry name" value="Staufen_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46054">
        <property type="entry name" value="MATERNAL EFFECT PROTEIN STAUFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46054:SF3">
        <property type="entry name" value="MATERNAL EFFECT PROTEIN STAUFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16482">
        <property type="entry name" value="Staufen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="174"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="282"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="373"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR16090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="578" mass="63147" checksum="0C072B5C1720B4C1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3K0</accession>
    <name>A0ABY7F3K0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17121" checksum="E86B304FE8D2E69E" modified="2025-10-08" version="1">MGQTSGELTVVTSANLQASTTPSYALRVEVEDNFGTNTGTATINISVKGSNATESPPGDDEKRTTLIVVTVLGGVLLVAVVVFIVYKNKPANVSFIGKYRRGSTVFPKREKTLSSITLRMNGKVDTSVNTDTQFNKQSYVEGTRTNEVSNNHLTRQSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4C3</accession>
    <name>A0ABY7F4C3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_005754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR15649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="309" mass="35355" checksum="437B7DF45C002B1A" modified="2025-10-08" version="1" fragment="single">MANAQVQIRFVNNQKGGESLLISGFRFNMKSCKPDRIYWSCCQQGCGTRATTVDGRLTKHTDNHTHPPNNVDNDIRNIMGDIRKRCRDELTPIPTIYEEEIANIRGKDWDEETEQMARHIPTFQTYKTALYKERSKLRPVLPTSTANIQLEGEWTQTTAGGEFLQINIDETNKMLVVATRTGLQHLCAANTIYADGTFYTCPSLCHQLFTLHGFIDGEMYPLVFAFLPGKSTDVYVNFFSQLKQKCEEYGFELQPETVFLDHEAGGVRQVKKRKYRQLEQRLAALKTRLENGHMTAMEYSDAASQLLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5Q2</accession>
    <name>A0ABY7F5Q2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR17512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="171" mass="19921" checksum="DFEDC04CECD3BEF0" modified="2025-10-08" version="1">MVLEMMHKLDNRMQSIESGITQISTMSADIQTLISQNSSQAEEILDLKCRMRDNLVFWGIPKNYNIDTEPNPTTDIHEQALRTFLTQHLETNTDINANGTIKINDIHFHRVHMIGGPSRNSQPRPMVAKFERYSDRELIRNAGIKLNMKHSGYYINEQFPPEIDERRRQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5U6</accession>
    <name>A0ABY7F5U6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_004786</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR14681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="969" mass="112051" checksum="C82B0088D84BBD03" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5V6</accession>
    <name>A0ABY7F5V6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MEG11-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_031576</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR16982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="301" mass="32244" checksum="78787318B20892E1" modified="2025-10-08" version="1" fragment="single">GYYGIGNNCNRSCPSGCNGQPCNNDGACLCKPHFTGNSCDSCVDGKYGENCSLQCSRGCEGNNCSPIDGSCTCREYYNGVKCENCITGRYGEDCLKPCSLENTCSPTDGRCDCNLFYTGDKCDVCEDGRYGEMDCHQKCSFGCHKVTCNPNGTCLCKPDFTGDTCNLCVAGKYGANCTLKCSRCCMGNTCRSSKGTCSCRRNYSGEQCENCIVGRYGENCSKPCSLGCLDNTCFSTDESCDCREYYTGAKCDVCVEGRYGSAEQNHPDETDTFQTGALTGGVIGGVVVLVASVAITVWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F856</accession>
    <name>A0ABY7F856_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAXC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_032401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026928">
        <property type="entry name" value="FAX/IsoI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01200">
        <property type="entry name" value="SUF1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="3">
        <location>
            <begin position="68"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="2">
        <location>
            <begin position="202"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR17807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="281" mass="32610" checksum="A00103F53AC87CFD" modified="2025-10-08" version="1">MESLLGFLQDNGKVFLTVAVVLGSAWFLYKKKTRTSYKPRVCGVDYPRDVVMLHALRRDRLAPNLGHFCIKLETYLRVNKIPYQFDGTSMPRPKEKVPWIEYNGVTMGDSQLIIQYLEQEFKVNLNAHLASKERAIAWAIQKWIEELNVYTRWVIFNDDMFKIQSTCPKYMKIPMRRKVESMLHAVGVGRHSKEEVHAMMVNDLKQFSAILGDWKYIMGDRICDVDCAAFGILSQIRWCTPSACPGNALLQGDELRNVTDYMDRIRNEFWPDWGDIISQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8C7</accession>
    <name>A0ABY7F8C7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="400" mass="43788" checksum="890E09121296DE4B" modified="2025-10-08" version="1">MYSEDILLRSLQPKLMLPMTRNMPKSSASEGNINPPPNKGGTAANVRKGTSSKSRTTAEIRRYKMVESLRVKENCIKGFKGGTLKSNPESLHSLLPLRKVSARPGSYSTGFTVRSYRNPNTAEILAEFEPSRPKTVPVNQAHQRQPLVPAPYFFKHFNKPRTANSTKKRNSPVSQPEGKYFHESPRDQFSVLNGEKIFGAPGTGTVSRSLRAGGARFSGLATLSNRRTVSKRGSTGLINVNGVNSSGPLELRAEGVQLGGGGSEERANQGELTGHATHTAPSSESGTGRSGRLTHNTPIMDPPQRQTSNNGTIRLDLENEDGKKQEIYLDDAGELDIEKARESEAKVASMQEDAKQRKKELEHLLQEHDEIVKTIVRQSSHDSSQDTFQSTSDASLLEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8X5</accession>
    <name>A0ABY7F8X5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="100" mass="11369" checksum="12F55EF133E9B167" modified="2025-10-08" version="1">MVKDTSSDKGVLHITTEGVQYAVVQRQASTQRIEPQQSHNDDSLTYAELDMKFLQVANTRVPSRRKNRPTEYADIEFFLTQEPAVEDPVYHNASASDQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9F1</accession>
    <name>A0ABY7F9F1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="97" mass="10583" checksum="7A4BD0C1BFC91804" modified="2025-10-08" version="1">MRYESDADIRYTAMASMKSLMFVMVLVALTLTSDGRRRKACRNDGATGNCAEVVGRRGALKGVGLCQKQGGTCMHFLRRGNMKCACIEVKPGTVTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9P9</accession>
    <name>A0ABY7F9P9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homolog subfamily B member 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Endoplasmic reticulum DNA J domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_000170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1. Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with HSPA5/BiP; interaction is direct. Interacts with ERN1/IRE1 (via the luminal region). Interacts with DERL1.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="34"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00041533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR18332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="239" mass="27823" checksum="2A0C9D0C6159443F" modified="2025-10-08" version="1">MLRCCCRHTLILCKNISRQELLPFARCMSYKDKTHYEILGVRSDVSPEKLRLAYLQLAKKYHPDVSHGREAQDMYILVHKAYGILSKPDSKSKYDEWLSSGGHKKKRKDFFSEETTDSKDFGLESPFPNSTQDYYLHPSFYKAGSLLRTEAEAVWNYHMKMEKADDHFRDMMTIKKDERQKVFNIVLAIVVAAGLFTYLATPSRKDFDANAKEMSKRRAMALEEIRKMQADRSDGPRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9T7</accession>
    <name>A0ABY7F9T7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047234197" evidence="2">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR17554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="154" mass="17060" checksum="B0CCE878AF0F4114" modified="2025-10-08" version="1">MLFKMLRIFITLALLAAVQCRFGGGFFHSDYYYEGESESESESESSESSSESSSETSSEPPPCPCTPLEVGQCCDDCHYCKDENAICDTYGYSKVCVCKDGFIFDYKCKKCVPGVAIRTSIMTPLRRNACKQSETGKASQAHDVNKLSVYIDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCM3</accession>
    <name>A0ABY7FCM3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CML16-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_000615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039647">
        <property type="entry name" value="EF_hand_pair_protein_CML-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10891">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR18777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="167" mass="19402" checksum="74B3D49372D90948" modified="2025-10-08" version="1">MNFADNIDIGQNVINEEVSTETTDQDITELFMMFDKDGDNKIEQAELKTLLRVVYKTNPDERMVEEQLHKFDTDRSGTIDLEEFKQLYHSMPYKPKGRKLRHMFDEYDANGDGDLSIEEVKQFLGSLGAKCSDKLVKKLMKEVDVNDDGRVDFREFCLMFGKSLSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDU5</accession>
    <name>A0ABY7FDU5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TNR16-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_002166</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052491">
        <property type="entry name" value="TNFRSF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46330:SF6">
        <property type="entry name" value="HEMATOPOIETIC DEATH RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46330">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00020">
        <property type="entry name" value="TNFR_c6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="7">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="9">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="7">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="9">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="9">
        <location>
            <begin position="111"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="7">
        <location>
            <begin position="111"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR20328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="224" mass="25451" checksum="ED69C1C4D07F1F30" modified="2025-10-08" version="1">MATSTICEEKLIQSRLPYLIKVLKLPSMCGPGKYFNNYMNGSGQCKKCRPCAKGYVELSPCSKNENTRCQLCPPGTFNDRRNGVCKNCTVCDKGFFVRRPCLPCKDTRCRKCPEGTFSVDGTRWACNYCTTCSEIQDEFLPCTTENDRVCKENRQVDSAQSEVILKEAKVEDNVEFNTHSRLVLVATCTAISFAFLIVLLAWTLQTYRRFADRYQLTQCQICVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FG11</accession>
    <name>A0ABY7FG11_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_001729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047548772" evidence="2">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="117" mass="12702" checksum="6421C0D37E9D5059" modified="2025-10-08" version="1">MESKKVYSLFYLLLLTITAPMLAVARSEDKRDVDDERRQIAVAPLAVYAGVAVSPWVWAAILAAYGIAELTKYNRPIVTHVPTIGVGVVAAAFHTSTLTHGTQQCVETTIAADPYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGA4</accession>
    <name>A0ABY7FGA4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20956:SF12">
        <property type="entry name" value="FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20956">
        <property type="entry name" value="HEH2P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="243" mass="28008" checksum="97F58A6771B81268" modified="2025-10-08" version="1">MLSCSVVDEAEVEYEVVEEGSNRKRQKLVSSGGFSYCVKRERPIPAGSRDAASGEKTCLAMRRLISGVRGAKEHCHPADPLIRKRVLLTRDVSESVFKDGEFNIPCPSNLMRRVNRSRQKVRPKDPTSLDFEVDTDYLLESFFIGDVRVGDERHLMFSTPSQLKFLGQARRWYLDGTFREVNRPLTQLWSVHAFLQQGESVKQVPLLYVLMSKRRKQHYVAVSKYHFKICIYVNIIIIINNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHV2</accession>
    <name>A0ABY7FHV2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="132" mass="15300" checksum="7EFFCEE6551BEAE2" modified="2025-10-08" version="1">MDCYRLLPLAEEYEIKPLLKSCETSLTESFANMRKGRRAGSVATDVTMQHLSCADKYNFSDLQEMCMEELVANDNPFSGKIVADSQELSEHVKRQVLERKLDRVNMVLARERRINTERDQSRDTKGGKIWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLN4</accession>
    <name>A0ABY7FLN4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PAR14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_015743</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057044">
        <property type="entry name" value="PARP14_KH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057051">
        <property type="entry name" value="PARP14_RPM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF102">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP14-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23084">
        <property type="entry name" value="KH_PARP14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23222">
        <property type="entry name" value="RRM_PARP14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="220"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="316"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="627"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="8">
        <location>
            <begin position="1199"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR21769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1555" mass="174660" checksum="7DA4431286F2585A" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLX1</accession>
    <name>A0ABY7FLX1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein-sorting-associated protein 25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-II complex subunit VPS25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_015833</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR21859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="175" mass="20395" checksum="56484CEDDE968DF4" modified="2025-10-08" version="1">MGSTEVPWQFNFPPFFTIQPNVDTRKKQLEAWCQLVLDQQRARNSHSLDVNEVHSSIFTNKSINRKLSVDGVIMVLEELRKKGHLEWKDPKTRKEALIMWRTPEEWGKLIYKYITGKSMTNTVCTLFELSNGEETEGEEFHGLELWLLKRALQTLERDGKAELMAFGDSEGVKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMN4</accession>
    <name>A0ABY7FMN4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Shieldin complex subunit 2 first OB fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049507">
        <property type="entry name" value="SHLD2_OB1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21669">
        <property type="entry name" value="SHLD2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shieldin complex subunit 2 first OB fold" evidence="1">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="89" mass="10110" checksum="37AC3C5174E7263D" modified="2025-10-08" version="1">MPHQRCRCYFSLQDSVATTVMVNDKEVNVRTITVEDRTGKVKVSLWRNIAAEPVVLGDVVAITNIVVNSKRYNNEESLSSTQFTKIEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMW9</accession>
    <name>A0ABY7FMW9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_016638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR22664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="187" mass="22382" checksum="4DE73D108E597D74" modified="2025-10-08" version="1">MRDNLVFTNIVKVMKTCSTDELYEDTETVLTEFLSSKLNLYSFQFERVHRMPSNRNPQRNAPRPIVAKISFFNEREEVHPSWYMLNGTTFGISEQFPEEIEMKRILHSRGQKKHTILVRDRLFVDGRQVRARGSRYIAGPKGKPRTADRKRHLWPWRRTPTLTWEPYTDPNWTSLQSRTRMADRRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPU3</accession>
    <name>A0ABY7FPU3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR22718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="58" mass="6875" checksum="64631BCD4A194529" modified="2025-10-08" version="1">MTICSGYSLLSCIIFTANTPDRTEQCYHLVFMDFIRYCSQFKRSQHHMLTFNLHPCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQF5</accession>
    <name>A0ABY7FQF5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CABIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_038109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025946">
        <property type="entry name" value="CABIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052281">
        <property type="entry name" value="GAREM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14454">
        <property type="entry name" value="GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14454:SF11">
        <property type="entry name" value="SERRANO, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12736">
        <property type="entry name" value="CABIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CABIT" evidence="3">
        <location>
            <begin position="64"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR24440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="468" mass="52241" checksum="D67D796AA578D31F" modified="2025-10-08" version="1">MAENEEIGDLISTPPENDELGDLVSTPPSIDWTESVTSFNSFDESSLPQVATFQISEGSGQPALPPGIALYSAQPVLFHTRTRKSHARARTIYHDQEGPYFEVGQTLDIPDDFQGWFEMVPPDFGRGQVFRTIGQLAEAGPRKFFTRTDIRALLIHPKEDENGNKEDDNDTSEPIDKRSSVASTTSAGKNGEGEKRDEGYSERKIPAGRVLEVKGSFAARWQTTTQSGLIKKKSKQYSTIEVPYMKCVDVDGTDVLIPFTTKGRFSVVYEKGIKDSRTVYRMKDILSDLQLPVKVRMVYGKAPVVPCIFTGVLVLKSKVVEDTIIASTILNKRNVLFEIPVSTKCDVRTAVDEEQYETLRTYIDAKMLGKKYAVPFGTLIKLSPELDTDQAMIQHIPTEKLKSRDESLQTLDMITNFSLTDEEPRDYFMESSDTESVQSADASPLGAGQMMELREIELPRVGQIYSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQM5</accession>
    <name>A0ABY7FQM5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OX2R-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_038189</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR24520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="79" mass="8789" checksum="8EA25C1651DC5A3E" modified="2025-10-08" version="1" fragment="single">MGTDQTEYMCVVGSAGNFLVCFSVWRSKSLRNATNYFLVNPAVSDSLVIVVCLPATIMLDALHSWFLGLAMCKVFIYMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRY1</accession>
    <name>A0ABY7FRY1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FGFR1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_037573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR23904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="124" mass="13761" checksum="638C3E8A1671CF51" modified="2025-10-08" version="1">MSKPHLYEQVQCGPWEITKANLVLTSDRLGQGQFGQVRKAYLKNIRSHDVPVAVKSLKVNASEKDKTDFMNELMILKKVGHHPNVVCLVGSCNIGGERGISHLEMNVDFSQFQVNRGIGSELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRZ4</accession>
    <name>A0ABY7FRZ4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RUSD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_037588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF87">
        <property type="entry name" value="RNA PSEUDOURIDYLATE SYNTHASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR23919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="271" mass="30764" checksum="B90DBBB02F1D4DDA" modified="2025-10-08" version="1">MMPKQGDGVQRPGLQVVHKSPNFLCVDKMYDLKINSDDPTDMTVEHQARAMFPELVDPKCSHGFRFVHRLDYATSGILCLGLTKNAAKHLSKLFHNKQVIKYYLALVRGHIVDEAVLIDVPIGRLDDAEWAGRMCAADHDKCDVPRPTATLLVCLERGMYGDKPATKVLLKPITVGDYTYSLRQDKTPHRMMLHSHRLVADMKIENLDLRTSDPFTTDLIDEWKPSEICRSYEEAESIAKGFEMGNMDSISGMDKFRLVRIKLSESQGEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSE0</accession>
    <name>A0ABY7FSE0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_038166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR24497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="201" mass="22896" checksum="43C0D677BD6952B2" modified="2025-10-08" version="1">MMHENMTHTGHIHTANGHMPPGGITHGHMAHGNMESGHMTPRGITHKHMTHENMESGHMINGVIKHGQVAHGNMVFSASYQRDFILKDVKISTVGGIVGAMLVVILLATFLEGFKHWLYIRQRNGPDHTQIKTIHFLLEQHCSYYYFTTKDVNGDRRVSFNAVCHDNERVDAGFCRTWRWNRLLTPTPCCKCMLCHEKDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVL8</accession>
    <name>A0ABY7FVL8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IPO9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_011952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="3">
        <location>
            <begin position="63"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Importin-9 central HEAT repeats" evidence="4">
        <location>
            <begin position="215"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="702"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="711"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR26248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="856" mass="95082" checksum="FEF02ADCB8C73366" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWI6</accession>
    <name>A0ABY7FWI6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CL056-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027878">
        <property type="entry name" value="DUF4551"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35354">
        <property type="entry name" value="RGD1561648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35354:SF1">
        <property type="entry name" value="RGD1561648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15087">
        <property type="entry name" value="DUF4551"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="759" mass="86164" checksum="066733A115C41DA9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FX25</accession>
    <name>A0ABY7FX25_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphoserine aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_011148</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="11"/>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00611">
        <property type="entry name" value="PSAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01364">
        <property type="entry name" value="serC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="11"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR25444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="373" mass="41361" checksum="250AF2984F694962" modified="2025-10-08" version="1">MPQNKEREHVMNFSPGPAKLPDEVLVQAQKDLTNYAGTGVSVMELSHRSKDFESIIQRAEQDLRSLLDIPENYKVLFMQGGGTGQFCAVPCNLMDLKPGRTADYIVTGCWSEKAAKEAEKYGSVNLVLPKTKKYTGIPPESEWNLNPDASYVFYCANETVHGVEFQFIPETNGVPLVCDMSSNILTRQVDISKFGVIFAGAQKNIGCAGCTVIIIREDLLGRALPNIPAVFCYNTMNTNNSLFNTPPTYSIYIMGLVFNWKKENGGVDGMEENSLVKSGLIYDVIDNSSGFYVCPVNIDCRSRMNVPFRIGSAEGCDVLEKKFLDQAAELGMIQLKGHRSVGGIRVSLYNAVTVEETQILADFMKDFLNKHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYB9</accession>
    <name>A0ABY7FYB9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CCD77-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037696">
        <property type="entry name" value="CCDC77"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22091">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22091:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="364" mass="43100" checksum="51DDFF8BF4380A43" modified="2025-10-08" version="1">MNVSSRIAGIIEKEPLPNINERLVELQKALSDMQIYLFQEREHVLRLYAENDRLKIRELEDKKKIQQLLALSGTPDSEITYFHKEPPAKAVKIQRNRPHLRRKAALHCQLKINTSMITKPCPCKSKLCSLKSKSRLNCPESRLHKTQDLLYESTKDFLELRYQGRASERLWMAEKDKLLRELDQCKQKLNISPKDDILTTPSSYDTKSHYIEELKSLEYQLQQSQKLSEMYREQVIQLEDELSRIREEGDVTREIFKDRGDKMGKRLKLMNQRYQDLERRRNLEVEGFKTDIKNLRTRLKDVERQLYKVTIGFSEDMDAKRPDDLDMQILRNIRATSGRSKKMVGELKNLKAKMYSIENDMKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYL9</accession>
    <name>A0ABY7FYL9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="142" mass="16748" checksum="F1E9F23FD53D02E2" modified="2025-10-08" version="1">MFEVRYYTSKACDLEYQSSVCNRTCFEIFWLEYEQHRGRTFTEKRRPRGKAGNLMFQIAALIGVAKRRGFTPQSRNNHYKFEWFETPRLYVNVSAVNVTNVGEGKYATYQTAVESFDGSHNWTLGGYRCSWKYFDNAKDEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0D0</accession>
    <name>A0ABY7G0D0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="122" mass="13564" checksum="611BB2D1AEBD6DF9" modified="2025-10-08" version="1" fragment="single">RTISNATSICVSCDELLSFPGFPAVASDDIDRLHFVKDKSSCCSSTDKILRMRIRKKMEGYEYNSGLSAGIEKLNNSFSIVNEFKDTSKPELSGTSLFCTGDLFLVCNNTIVNIKEIFVFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0H7</accession>
    <name>A0ABY7G0H7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">POC1A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_012521</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat POC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR26817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="157" mass="17870" checksum="1337C6B9851E7AA5" modified="2025-10-08" version="1">MTSPLEDPSLERHFKGHRDTVTSVDFNPNMKQLASGSMDNCLMVWNFKPQMRAYRFVGHKDAVMNVRFSPSGHLVASASRDKTVRLWIPSVKGESTVFKAHTATVRSVDFSGDGQTLVTASDDKTIKLWTVHRQKFLFSLNQHMNWVFPGWPTDCVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6I3</accession>
    <name>A0ABY7G6I3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FCN3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_002500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR28932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047234210" evidence="1">
        <location>
            <begin position="23"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="233"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR28932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="388" mass="44132" checksum="E36A0D26F3F63B86" modified="2025-10-08" version="1" fragment="single">MWLQTLPVILLVLTTSAVHVTADRLSRVESELKQIKIFQSFIIARMDTMEIDIGTLATKVARIELLENSTESENAGTYIPKTDHKTEHVEKQSELKQVQSTLKMYKHSFAKHKKKFLAINNVIKDTLVVFRENASTTITNLVKTVNEHVKNSSDNVALTLENISNSSAESESTLRSEVLNYSKNINAEIQKNLDTQLQATTTEMKNTMKGLIGKANKVVGIIDERRSTIEDNMFGVISSHDCQGFLKQDATLPSGVYNITLDTGENVSVYCDMETSGGGWTVFQRRWYGNNENFNRSFAEYENWFGSLDGEFWLGLKKIHEMTRKENVTLRVDVQSMDGTIGYDVYSDFFISSPDRYEFHTASDNRPFSTYDRDMDNLEKENCAQERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7M2</accession>
    <name>A0ABY7G7M2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C163A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_002972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRCR" evidence="2">
        <location>
            <begin position="63"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR29404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="174" mass="19813" checksum="1EABFD31CBA9E944" modified="2025-10-08" version="1" fragment="single">ELTYNRDEVKVISNRVDILENTTVTHDPSSPNQDKTVTFYNLGDKTGESGKTLVRAGNNEANIRLANVYPYRSTGVQGRLEVRHDRKWGTVCDDSFQSYVGEPYIINNVNMVCRMFGSRECQYMLNAVQGRGSGEVWMNYVRCDGQSSFLDCPHEGWGKRPCSHGEDIGFRMWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8L1</accession>
    <name>A0ABY7G8L1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GBP6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_032799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1000.10">
        <property type="entry name" value="Guanylate-binding protein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003191">
        <property type="entry name" value="Guanylate-bd/ATL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02841">
        <property type="entry name" value="GBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate-binding protein N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate-binding protein N-terminal" evidence="2">
        <location>
            <begin position="40"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate-binding protein/Atlastin C-terminal" evidence="3">
        <location>
            <begin position="166"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR30257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="646" mass="77380" checksum="C0A633D6AA02F47F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8R2</accession>
    <name>A0ABY7G8R2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MAR_033342</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">MELC-2E11</strain>
            <tissue evidence="21">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RLR subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.30">
        <property type="entry name" value="RIG-I-like receptor, C-terminal regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041204">
        <property type="entry name" value="RIG-I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038557">
        <property type="entry name" value="RLR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021673">
        <property type="entry name" value="RLR_CTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051363">
        <property type="entry name" value="RLR_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074:SF16">
        <property type="entry name" value="ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074">
        <property type="entry name" value="HELICASE WITH DEATH DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18119">
        <property type="entry name" value="RIG-I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11648">
        <property type="entry name" value="RIG-I_C-RD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51789">
        <property type="entry name" value="RLR_CTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="458"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="742"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="RLR CTR" evidence="20">
        <location>
            <begin position="929"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="222"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="905"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="WAR30800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1095" mass="125382" checksum="2895820037F1AB27" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G979</accession>
    <name>A0ABY7G979_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZN235-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_032994</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR30452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="412" mass="46014" checksum="9E1DE095819D6291" modified="2025-10-08" version="1" fragment="single">MARNATITATTTTTTDRMARNVTITATTTTDRIARNATITATTTTDRIARNATITATTTDRMARNATITATTTTDRIARNATITATTTDRMARNATITATTTDRMARNATITATTTTTDRIARNATITATTTDRMARNATITATATTYRIARNATITATTTTDRMARNATITATTTTDRMARNAKIITMTQTTKYFLKSTNCKTVHSHFNMEENAAVDSEKCSSSSEQSEDSTADNDAETLQKSKQFKCKMCCAHLSSKLTLKRHMVIHSGEKPFSCDTCGKSFKFISELNVHMKRHSGLKPFACDVCDLRFTFRFMLMAHKRKHTGEKLFKCAECEESFADRRSLQSHMNKHNGLKPFKCEVCDKEFTIKTYLTRHQKTHDTNIKKPYKCTECPASFTQNSLLQAHLIRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAR8</accession>
    <name>A0ABY7GAR8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FBP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_034064</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF9">
        <property type="entry name" value="NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="103"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="141"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="179"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="217"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="255"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="293"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="331"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR31522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="461" mass="49421" checksum="0BE335A74E89F3DD" modified="2025-10-08" version="1">MMSASLPPPAEAFKNISLIVDGKEVENITDDVIQESLEPEYTTEVLNEIATNDCPQECFGRGNCNNALTGCNPCLNNAICINGYEGYSCMCADGWNGTHCEQNINECESNPCVNNGTCIDGVNGYTCACTDRWEGPNCDLDIDDCLTNHCQNNGSCEDGFKQYTCKCAGGFDGTHCENEIPTCDGEPCQNGATCHDMADGYSCTCAVGFSGTFCEIDRDECENVSCKNGATCIDGANSFTCRCDVGWEGTHCQINADDCAGDPCKNGATCSDGINSYTCLCGEGWDGPTCEINADDCAGDPCKNGATCSDGINSYTCSCIDGWDGPTCEINADDCASEPCKNGATCTDGINSYTCSCADGWEGPSCERTLATKTDDIPLKIVFNIPLEELASSNLTDPNTVKELINAVEPPKRSSGIHFSRPAFNHRACCRTVISDIVRINDDHLLYENEKTKNGKDFQCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAU8</accession>
    <name>A0ABY7GAU8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HS3SA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_033787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF72">
        <property type="entry name" value="HEPARAN SULFATE 3-O SULFOTRANSFERASE-B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="83"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR31245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="195" mass="22151" checksum="94213C540BB2E685" modified="2025-10-08" version="1">MFPILVTEVMRQNLSTVVGEDSSPVVGKYIVGQKKEQEETELLKLEIDNKVRKELTERGLNKIRDLGRFDLLEQRECKKRLPEALIIGIMKGGTEAFSIFLALNTKVAMSLNTATTMFFTSNYHRGPSWYRDQMMCSTGDQITIEKAPQYMPSASAPLRVYRMNPDMKLIVLVRDPIARAVSHYLQVRIAAPKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GC03</accession>
    <name>A0ABY7GC03_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_033566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="103" mass="11818" checksum="AB7CDAFF93ACCE7E" modified="2025-10-08" version="1">MKTVTTQTMNVSGNLFSFLHFDQRTFYAVTPLCFKTAIDEDGLNSILKNDSRFGTVSSFADKPSPDKYLRGYLYTNPERGRRHFDVVVTIRLSFCLSFCLPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GDL9</accession>
    <name>A0ABY7GDL9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ANGP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_034136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF379">
        <property type="entry name" value="FIBROLEUKIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="317"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR31594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="498" mass="56124" checksum="5357AE2CB8605A3E" modified="2025-10-08" version="1">MEATVGDTGRDGTIQQNTDMVGYFQERNKTRKSIHEARVMIGRMVWLHLFVVVVMLTIPTCVGDRLARMERQIQLVKGFQSYVQLRLDTIEGDFGTLSERVSNLESLVKSSDNNTGETNNPTNVPTKGTINTQSAFNDIKTTLQMYRYSFQKQKKELVNVNHDVKDTLSAFLSNASKTVDTLVNSNVYATRAHVQNETIQLEKKVEELIGRANKVVGIIDDQRSTIEGGIMFTFPGVTGLHGPTVLSHVTREEEVDRGHVMYLPLLLMAFVLVMIQKQRNALFASFVHRMVNGLCGRHGAHVLCPVVTALRPETDPAPIQLLLMVERDVLKRGLSHGSGVYKISPWNTDKEVDVYCDMDTDGGGWTVFQRRFDRSVDFNRSFVEYEQGFGSLDGEFWMGLGLLHSITSRANMTLRIDLSLPDGTTGFDEYSGFYISPPDQYNFNVDRRIKSAGMSDSYLLSDIGSNGDINHQPFSTYDRDVDKWLYDNCARYLGGGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GDV8</accession>
    <name>A0ABY7GDV8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C1QT3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_033853</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF102">
        <property type="entry name" value="CEREBELLIN 13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="105"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="5"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR31311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="242" mass="26921" checksum="3019D4409247DFBB" modified="2025-10-08" version="1">MLEKMVRTEVKMKELLGKLEALEKRQTNAETEMDTSTKKIQDQVLKHDSEIEMSAKGIEDLEKQYDSLQTECENTTKSYFNRHEKSLELLDQRLDSMSRNCTESMHPSSVAFFATLSSGFTTSSSGQTLVFYNVIKNVGGGYNPGTGEFTAPVDGLYVFSASVMVDLSKSRTAAHISIYKNDSFVVYLYVIDSDGKYETGAGTVILSLQVGDTVKVKCIYSGRIIRRYSLISVSEDTVPSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAG8</accession>
    <name>A0ABY7DAG8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="76" mass="8463" checksum="7E922670795D468A" modified="2025-10-08" version="1">MPSEYRKDFSTSLISIDGTEINTQSPYALGLQSQIWRRLIADKGFTIHREISDLGLKLNSPPVAITNSQMPALDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DB91</accession>
    <name>A0ABY7DB91_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FGFR3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ93649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="217" mass="25148" checksum="ECC34181F259F1C6" modified="2025-10-08" version="1">MLSFIKCFLNPVGPMIIYEFCENGTLREYLEENKCNMTVEMKKTLFGFGFDIAKGMDFLANNAVTHGRLAACNIFLNQLNAIKIAGFWPETAGEENGEDAESEKKERILIRWMAPECMTSTKMANGRSDVWSYAVVLWEIFSLGETPYTGKTRDLPQRLKRGERLGKPEHCDDKWYSVMQDCWEYEPRKRPCFAEIRDQLDKLFVNSPGDTVYYNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBY5</accession>
    <name>A0ABY7DBY5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_027862</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAQ95172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="315" mass="35441" checksum="3504D04D814E2620" modified="2025-10-08" version="1">MKKYLKSMNETEDKPSHNASVVVLSTGAQGTGTSVLLKMDKHSYIFNAPDGITRAMFAGFLGEIPAMENNSILRMRHAFSEKGKVKRNSIDIPEKHKDGDSKLERSKMKNSANVKKSSPQIDTEAILNLGMESVGSSIQGIPPVTGQNCDILIHEATMFDVQLQAAKNLCHSTVSQAIRTGKQMNAKFTLLTHFNKRMRHIPLFSDAFTEDVGYAFDFMQVKPNQLHLLYHMKPVFNALYGPSIASQELLMQKYASARNQTEMFSKGILEARETQDNLNYIEFLETCKMDRNHWKNGNLMEKLKIVEDNSDKDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DC94</accession>
    <name>A0ABY7DC94_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="709" mass="81444" checksum="366009CF78081A4A" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCB2</accession>
    <name>A0ABY7DCB2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="98" mass="11322" checksum="A4D43FE999E6FC00" modified="2025-10-08" version="1" fragment="single">MGLQKPHHQKSLTLDVHAEPWFVFIDTFNVIFMMLPDRWDSWATLDLYIDASNIGFGGYFNDRYLAGVWPVNRQNKCIVAALIDITPQLLRIAALVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDE4</accession>
    <name>A0ABY7DDE4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SOAT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_007537</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF8">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ95066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="551" mass="63115" checksum="6D95E812005567C1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DEC8</accession>
    <name>A0ABY7DEC8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RBMS1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_007573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12244">
        <property type="entry name" value="RRM2_MSSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="94"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="173"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ95102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="380" mass="41300" checksum="B332A14DCE4C5DB7" modified="2025-10-08" version="1">MIKQVKSGVQYHPYLTYQLILNEKTVDTAIYGGSVTDKFFCPMGINRHATGGPLLLALLVINEETYTPRNMPAASPNTSQSSGGSQSGDQLSKTNLYIRGLNPNTTDKDLVNLCNPYGKIISTKAIVDQTTNKCKGYGFVDFETNQAAEVAVQALQAQGIQAQMAKQQEQDPTNLYIANLPLYFSEQNLENMLKDYGTVISTRILRKPDGVSRGVGFARMESKEKCDAVINGFNGKILPGCTESLLAKFADGGNKKKVPYIQPTKLWANGTDVTIPTLAYDQAALAQNGFYLPYSIAAPGAAALMTPGLLPRYSMASSPQTYQVQSNPGAFINPQYIMQPPMAHYAALTNPGYTQEHLEDAQAHFQAYTSSPANPTTILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DEL4</accession>
    <name>A0ABY7DEL4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="219" mass="24449" checksum="7043C5D609EF5517" modified="2025-10-08" version="1">MEEDNRDQKLKAGKEKLAQFQRKKRKKRPHGRKETGEGDGCQGDDYTSPGEYTSPGEVPSEVTDIQQNIPPNMAVNSVIYGLPTSTTKETDIERSTGNPNNKSEESEKHFFGDMQNQQMTIGSQQSAMFTDVKNQSLPLCTNAGSQDITKTENGSYQFVNGSNSMGVGDQSLPFCTNTGTQQLINGSQGQEFVDRNQEDEIQELHHVVQWLKLQLTKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFB5</accession>
    <name>A0ABY7DFB5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PZRN3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_029032</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF157">
        <property type="entry name" value="RECEPTOR-ASSOCIATED FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="7">
        <location>
            <begin position="102"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="102"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="536"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="593"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="738"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="989"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="460"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="593"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="652"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="664"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="691"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="763"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="793"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="827"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="852"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="926"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="944"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="989"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1036"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1051"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ96342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1141" mass="125068" checksum="1261527C1BB09F19" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHP3</accession>
    <name>A0ABY7DHP3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GGH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015527">
        <property type="entry name" value="Pept_C26_g-glut_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315:SF0">
        <property type="entry name" value="FOLATE GAMMA-GLUTAMYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315">
        <property type="entry name" value="PROTEASE FAMILY C26 GAMMA-GLUTAMYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="183"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="380" mass="42607" checksum="A24694841E072F91" modified="2025-10-08" version="1" fragment="single">HVLSAHGDREAVKIAESCLDSPAIWGHFTRGRIKHHSGILITLAANNQYLTLLWDYSIMVKMWHVANNSRSATLFKFHDVSMSPEGLGVDCGYPQCTSSLPAYDDTSATSQTGVLAQESSQSSVKYGDTFIPADYFQYIEMGGARGVPVLVLFPGGGVSLTTSKMARAARIIYKLAIQANDAGRYFPLWGTCMGFQLLTVLTAGQNLMTNASVWDKALPLNFVNGYKSSRLYGSLPADVYKYLSTLNVTENFHNYGITPETMSLNKNLKKFYNVLSTNVDIYGKIFVSSFEGKQYPFYGVQFHPEKVSFLWNMHYHINHGPEAVRVGEYFANFLVGEARKSTNHFTNQTEEIASMIANYKPRFFKDATFELEYFFNLTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLW9</accession>
    <name>A0ABY7DLW9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">GRIA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_023020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAQ98647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="393" mass="44619" checksum="9BCE0AE7DFB91D05" modified="2025-10-08" version="1" fragment="single">GYCIDLAKMLQEKCDTPYDYYIDLVGDSSYGTWYKDEGCWDGMIGELLDTRKCPKGGERKKPDKEKPGIFSFMYPLSNLVWACVMLAFVGVSLVLFFVGRWSPLEWAEQDPKGGTPINNFNLLNTLWFTLGALMQQGSDTFPRSYSGRIVGSAWWFFTLILISSYTANLAAFLTIERLTPPINSADELVRHPKIKYGTLSRGSSRAFFKESKVDTYKKMWNHMSAHEERVMVNSTLSGVTKVRNSKGEYAFLMEEAYNKFHNQRRPCNTMRVGNNLDNKGYGIATPIGFYLKNQINVAVLKLREVGELMKLEQKWWYSKGECGVDTKLLKAQKNHQAVRIVKKEPLEALKDAGYAERESPMFTYPSPGSTTAASAHLVTFDNTKYSFTSSPDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMW9</accession>
    <name>A0ABY7DMW9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GEMI5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_022252</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056432">
        <property type="entry name" value="Beta-prop_GEMI5_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052640">
        <property type="entry name" value="Gemin-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46362">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46362:SF1">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23770">
        <property type="entry name" value="Beta-prop_RIG_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="95"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Gem-associated protein 5 first beta-propeller" evidence="4">
        <location>
            <begin position="144"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ97879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="465" mass="51536" checksum="3DCA1715A54BC5DD" modified="2025-10-08" version="1">MPSVIIPASPNWYCSKVTDSNKRNLLVYAARHDVYIFGYEEFPPKFLGVCVEHREKVTALTLCNHDEYDTLCCSGSEDGVVKLWDTTDKSLKLENHVHSHKVTAICWSNQQKDLIISGDDHGTLGVWQFEENRQAAHRLEKAGIQCLAVAPYSPGLVAVGLKTGQLLLVDVKKGGHVVSSLKGHDEEIYSLAWCPVPGEDFKPAPKSEADITDLESFGVDDSWRKKPKEVPSSKIKGFGEEGWLLASGSKDKTIRIWSTSRGRQLLLMKLPSPGRRERGDEGGRGKAWLTLCWLQHDSCRIISSSQSGDILVWDITKVGKEKMSVLNSAGKGHTRFAFNICPLGGDTRTVCTISMDRQIIFWDVDLRYQLGVLPSLGGYVYVAKVSPFDHGRLALGVGDAMIRLWNINSPVPGSTEMTQLWQGIRAKVTALCWHPAKEGILAYGTDDGRVGVYNTLSNKYGLMFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DN82</accession>
    <name>A0ABY7DN82_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_022372</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.95" evidence="3"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd13210">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048994">
        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="13">
        <location>
            <begin position="212"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="12">
        <location>
            <begin position="720"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAQ97999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="778" mass="88047" checksum="A937DC115ED65792" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQD3</accession>
    <name>A0ABY7DQD3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Snurportin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_024285</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the snurportin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017336">
        <property type="entry name" value="Snurportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047857">
        <property type="entry name" value="Snurportin1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13403:SF6">
        <property type="entry name" value="SNURPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13403">
        <property type="entry name" value="SNURPORTIN1 RNUT1 PROTEIN RNA, U TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21974">
        <property type="entry name" value="SPN1_m3Gcap_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Snurportin-1 m3G cap-binding" evidence="11">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="207"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAQ99912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="356" mass="40777" checksum="3D8C7F0464B7935C" modified="2025-10-08" version="1">MAMLMESRWFREIPEQFDTDWVTLACPTGQRCLVMAIDGETKWFSRKGYKLPGYFLSVLPGGNGTKYGFGPTVKTLLDCVYCEMMSTYFILDAITWADHDLTQTPFQERMSWVKRQISQNPELKHITDLNMFKFVPLYHFDCTEEGLGKAVWQSRFETDEVRWIKPYMLPEVFNNMAIPNSLLTEAPADYRGYASFLEDVDNGRVKTKKNKNFKKSKQKKEFVPRVELKLPPPQEKPKKDDTKTKKQNKRGGGQAGRWRGGGSGQPHSHFKAYSGGDNYSRVPYSGGDNRGAFGQGTRSGHDYYGDERDYYYPEQEYGPDYRVIGIGSDENEISIDNIVYDARDISSGERSSSLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DR70</accession>
    <name>A0ABY7DR70_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EPHX4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="65"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="280" mass="32353" checksum="99F29B163230F07E" modified="2025-10-08" version="1">MKHTLIIFIIGPIQFIKLNVLKLKKRNVMPPCLNDPSLGNHDFVHLEDVRLHYVASGDEGKPLMLFLHGFPEFWYSWRFQIREFRKDYRVVAVDMRGYGDSDKPKGKENYTKCFLVGHDWGGTVAWNFASNNPELVEKLVVCNCPHPATFAKYMGSHFSQYMLFFQIPMLPEFLIGMNDCASFDGLGEWVPNNKPTPDDIEAYKYTFSTRESRTCPVNYYRAAFNSENRCKNIIVPTLIVWGDPDKAFNTEMAELCRENVEDLKVKVIANSSHYVNTLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRW2</accession>
    <name>A0ABY7DRW2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="12" mass="1292" checksum="281E723EC8A735A7" modified="2025-10-08" version="1">MPSMPSLTHGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DS78</accession>
    <name>A0ABY7DS78_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZD2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_024930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055287">
        <property type="entry name" value="IL-16-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48484">
        <property type="entry name" value="PRO-INTERLEUKIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48484:SF2">
        <property type="entry name" value="PRO-INTERLEUKIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="153"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="468"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="598"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="794"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR00558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1024" mass="112156" checksum="E9FE2997830740CA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTB0</accession>
    <name>A0ABY7DTB0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_024696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028996">
        <property type="entry name" value="GM2-AP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357:SF0">
        <property type="entry name" value="GANGLIOSIDE GM2 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357">
        <property type="entry name" value="GM2 GANGLIOSIDE ACTIVATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045622709" description="MD-2-related lipid-recognition domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="3">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR00324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="261" mass="28401" checksum="24B8BA062733BA22" modified="2025-10-08" version="1">MFKSIVIAACLVCARAAVEWSDCATKGSQTALTVNAIDFHPNPVIFPGELHVDLDMTVTQRMDQLFVDVELWKNTTFGESKIPCIGDTNIGTWYNIDACSILPRIRNGSSIVSADLGLQIDKIILTALGHEGNCPIQPENVTLHNEHITLQALPAELSLIATGDYRIVFKIKDDPASSDNIGCLEIKAGIRRKTDQALLQVPSECMSECYIEESMASLPAGWVARIHGSSTLPHVAMVMVARPGAGRDDVGHISNKEIEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTD8</accession>
    <name>A0ABY7DTD8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ORN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_025375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR01003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="101"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR01003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="258" mass="28878" checksum="2506717A4D0B1A73" modified="2025-10-08" version="1">MAAPLVAVGDTEGFLLFSTKKLCVQKIENLDFNFLFNLWGQHEASGFAHRGDSATLICLLFYAGWRHSAGGSAGTRPLDTGRGRSDVLLSDVLGGFLSKMREKHSSSEMSGLDVNKEHILEMACLVTDQDLNIIAECEDLVIHQPPTVLDNMGEWCKEHHGKSGLTEAVRRSQISLMEAEDRMLRFVKEHTLPGSAPLAGNSVHADRTFLVKYMPRFTQHLHYRIVDVSTVKELSRRWYPSEFSRAPKKKLSHRQSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTT6</accession>
    <name>A0ABY7DTT6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CNBD2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_024859</name>
        <name evidence="4" type="ORF">MAR_024876</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011:SF38">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="145"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR00487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR00504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="584" mass="66689" checksum="038424A2D256DBB3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTY2</accession>
    <name>A0ABY7DTY2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SHKD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_024674</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF298">
        <property type="entry name" value="MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="8">
        <location>
            <begin position="217"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="712"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="592"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1014"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1081"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1234"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1339"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1410"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1579"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1715"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="670"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="338"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="522"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="603"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1029"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1081"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1249"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1599"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1613"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1668"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1690"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1723"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="746"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR00302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1753" mass="196854" checksum="021DEA7F20AEF130" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DW75</accession>
    <name>A0ABY7DW75_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M130-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055188">
        <property type="entry name" value="Choice_anch_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052956">
        <property type="entry name" value="Mesenchyme-surface_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46928">
        <property type="entry name" value="MESENCHYME-SPECIFIC CELL SURFACE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46928:SF1">
        <property type="entry name" value="MESENCHYME-SPECIFIC CELL SURFACE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22494">
        <property type="entry name" value="choice_anch_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Choice-of-anchor I" evidence="1">
        <location>
            <begin position="155"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="505" mass="56222" checksum="A001884962F23C03" modified="2025-10-08" version="1">MLLLLVSEECTFLKRAMWNINLFTHAGTRNRLLHAIDVANPSSPLRILTHQFTEHEGNPQAVDVCGGRLAVALSAHVDVLEGHVQFFDVVARGSSVTDIHPDHTLAGYKANNIVWIWLFKLILVCYLFTSNKAAFNVLLLPNGCNKNIIPLFINTISPITAVGAHPKDLKHTPNCNMVLVANEGRPGKDDTNQYLNPEGSITVIVIDRNNDPTLRTIDFQQFNEGEANFNQNIRTPSRYIPKSVYSGTTTVAQDIEPESVVISNDGRYAWVTLLENDAVATLDLRTYQVTKVSPLPKKLWDTSPVDCSDLDGGVHRRTYAGLKSMRQPGKITLLQIGSKNYLITADVGGVTSYTSALHGFTWTDTITARSLVNSLMPDLVELKTQMTDNGFLGRLQVSTIEGNSLFDPRYTHVEMFGGRGFSVWDSTNMAAPTFDSEGTLEEYMDSYYHFLFNTDYAANRATTGSPANDRDTSSENQVRQRARTTLWCQRHCQTCTPYSFVSDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DX42</accession>
    <name>A0ABY7DX42_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RPH3L-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_007740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd15746">
        <property type="entry name" value="FYVE_RP3A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041282">
        <property type="entry name" value="FYVE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030541">
        <property type="entry name" value="FYVE_RBF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043566">
        <property type="entry name" value="Rabphilin/DOC2/Noc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45729">
        <property type="entry name" value="RABPHILIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45729:SF6">
        <property type="entry name" value="RABPHILIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02318">
        <property type="entry name" value="FYVE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR01182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="129" mass="14332" checksum="AF70B35A5D634D64" modified="2025-10-08" version="1" fragment="single">MNVIQKADYLESVEQERIGRLVEKLDNMKKNAMGNGTTQCVLCGDEFGLLGASPTYCDDCRKAVCTKCGVDTLNCNRQPLWLCKICSENREKSESSKLGVKSKPEYRGTPRAQTGAVQTYNNWSRGRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXM2</accession>
    <name>A0ABY7DXM2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_009016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046604915" evidence="2">
        <location>
            <begin position="26"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR02458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="276" mass="29465" checksum="DF11B9BC25A2725A" modified="2025-10-08" version="1">MVDNLIETRMIQFIVLLGLFCLGGAYEVCSTSNFGYNQYYTYCEGNTYCCHDDTECCKSLTGGQIAGIVVGIGFLISLCVGCVVCCCRKNRRQPPATMGMQASPSAPTVSYIASPGGQPQVNYGAPPGGQPQVNYGAPPTYSQAAYSTGPYPQYPAPYAHAPTSEAPSQNGQYPTDGARERLTSGVDVHVISEAAVGAELLLANLAEVAVVQSLMLREETMRHHFVAKAALETLIVQPDVSCDIAVLGEQRLPETAWSVLELVYTLMVLCVSAVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZ50</accession>
    <name>A0ABY7DZ50_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="170" mass="16703" checksum="74EDC4F6FF04E649" modified="2025-10-08" version="1" fragment="single">TCSAGNNECATTAYSYCDTSTTTCTCAAIAPVSSGTCTPTACANDGECTTLDANSKCTAGSCTCTDSYYLDGADDVTTCVAKAVGVTCALGECSVTPGQVCDNTLASPVCACALGYKDSSGTCTANVEGDTCTRDGYECIAAGSAFCDTSGTTSVCACGAVYTLTGCVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0E2</accession>
    <name>A0ABY7E0E2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAX-interacting protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PAX transactivation activation domain-interacting protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_009282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd17714">
        <property type="entry name" value="BRCT_PAXIP1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17710">
        <property type="entry name" value="BRCT_PAXIP1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17711">
        <property type="entry name" value="BRCT_PAXIP1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17730">
        <property type="entry name" value="BRCT_PAXIP1_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18440">
        <property type="entry name" value="BRCT_PAXIP1_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051579">
        <property type="entry name" value="DDR_Transcriptional_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196">
        <property type="entry name" value="PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196:SF1">
        <property type="entry name" value="PAX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="411"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="488"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="676"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="767"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="882"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR02724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1071" mass="118544" checksum="07DD5564FF4799E1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E144</accession>
    <name>A0ABY7E144_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BGBP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_009245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the insect beta-1,3-glucan binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2140">
        <property type="entry name" value="Beta-1,3-glucan-recognition protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031756">
        <property type="entry name" value="BGBP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043030">
        <property type="entry name" value="BGBP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15886">
        <property type="entry name" value="CBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51969">
        <property type="entry name" value="CBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM39" evidence="7">
        <location>
            <begin position="14"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="6">
        <location>
            <begin position="212"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR02687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="522" mass="57092" checksum="D94F62554328F92A" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2H8</accession>
    <name>A0ABY7E2H8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S6A14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_009972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR03414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="265" mass="29801" checksum="CDF52E99063CF6D7" modified="2025-10-08" version="1">MDSNFPVLFHCEIHWNPVLSPTANIVFIMEYPDTVSVSSSGHQQQRKAVKFSSTFSTYMTLLGYALGFADIWRFPFLVYRNGGGFSTGLVALKAGFRIPTLIVITVVMFVLSLPTCTGAGAYIFLLIDWYAGSWTGTIVALIEVILFLSCVEYVPPNYGSYHYPGYAQAIGWGTVVVTVAPIFGYAILNLYRAKGTVSQRISSLCRPTDTWGPCGDRMDCNYRKNKIKYSERTFWDLFYFNVFGRYPKNSAINLLLDHELTILKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2I2</accession>
    <name>A0ABY7E2I2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SOX6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_009703</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd22042">
        <property type="entry name" value="HMG-box_EGL13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="347"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="347"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="458"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR03145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="639" mass="71239" checksum="2E991C86053D6CF3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2S1</accession>
    <name>A0ABY7E2S1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFGM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_019681</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22823">
        <property type="entry name" value="Gal_Rha_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.30">
        <property type="entry name" value="Designed four-helix bundle protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.950">
        <property type="entry name" value="Methyl-accepting chemotaxis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047037487" evidence="4">
        <location>
            <begin position="20"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="8">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="5">
        <location>
            <begin position="229"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="6">
        <location>
            <begin position="416"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="608"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="580"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="117"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR04312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="779" mass="86739" checksum="EB0A16E96F374F23" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E302</accession>
    <name>A0ABY7E302_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ALS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_009454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR02896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="883" mass="100627" checksum="A8986745244E3169" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E425</accession>
    <name>A0ABY7E425_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_009814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR03256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="434" mass="48409" checksum="ECA646CD02B5C763" modified="2025-10-08" version="1">MRQNSVSGQVSPHLDEDCFVKKDNKDPLVETMCFDVISMDIKTCETAVSVSSGVVVVLICLNVAGLTFWVRKRRQRRSRQLSVTIDSQPQRTIESVQPTVQPSCTTGYSLVPDFDPHSLHVDSISPLATPDMQCASQQMPRNSPQMPRNSPHMPRSSPHMQRASPQMPRNSPHMPRSSPHMQRASPQMPRNSPHMPRSSSHMTRSYPSAPPMEKNTTRKPGYWKKGEHFCQYEIVNIGQKMEKEFALIVILCHTLCIWRCARAETVTISSDTCGDYFDFGSDSFIGPDVTVLYKGDPVNTRLEDGCYIKLSWSCGSSTCCTWCGTTRTSNLYVLVKSSHAASLPVVDDVKLRFYRKGLPGRKSYESSSQPQYGQPAAGYSPYQPHPNTNQYQPAVTPSAPALGGMAVTTQANIYEQLDVEAGLFEKREETIASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6G9</accession>
    <name>A0ABY7E6G9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Outer dynein arm-docking complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Tetratricopeptide repeat protein 25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_021012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040111">
        <property type="entry name" value="ODAD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR05643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="100" mass="11421" checksum="3D6C789707AD6999" modified="2025-10-08" version="1">MLSEDQYGRKELLLNEMAKQDGEANYEKQSYTKAIKSFTQALRHVPDDVAALVGRSRCYSRLRKFRRAADDVDMALHIDAVDKASLERADCWASIAFPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6Z1</accession>
    <name>A0ABY7E6Z1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="78" mass="8809" checksum="43D66C3CCF26E4E2" modified="2025-10-08" version="1">MQYLGVANIALQIEYHHARKKNAGGLIYADLVFAKPPKGQKRLVIHGLDDMTEYAEVDLTKKTDPLPDSDEEKEIKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EA38</accession>
    <name>A0ABY7EA38_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_016865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045661950" description="CUB domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR06907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27700" checksum="9D3E305B824953C8" modified="2025-10-08" version="1">MYNSIEWTALFLLCIHTGHTSGSVQVTSDRCGQTFDLAETGDLTLTFDGDRLDTDKEPACAYHFNVRDNSGTVCVEFVVFNISSPQTHIRVKYYDGPYVASMPTEEFRYHNLPPADPICAKFRSVTVTFESRNGSASAAYIEVRAFPKDEGVNHPSADRTLAGVYTVIVIVVVTMVTSVTMAIVIVVCCLRKHQLLCFSHHLSDDEKNGIWLSDLKGVSSVRSRPGTAASRPQSSLHVNQEETQYDLPGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EA63</accession>
    <name>A0ABY7EA63_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_021244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR05875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="420" mass="48043" checksum="3D95E86FD430C6B7" modified="2025-10-08" version="1">MAELTVSTPKKHHLQDRCVLCGMVFCNVEITPSGRKIKTSVNMNKKLKITKQTVDDLHLVIDMDLTSTDATGICIKCNRLVKGVVEKLQIIKQTLNESIGYSLPQGIKDWEADQQLQWLNDKCGEIVKEIFPHDLFAELQNVLADPDHEENYWVNSIENDNFKCHFCNARYKYVTSLKMHEKTKHQVNMSAKVQTTNSLLRQTDELNDYLVSVFRLTALHQNLNSAVDMGDGYRVVRSAKFETPIYNRTNKVKYLIGSVHLTALVSGTLPAHQSKRLIANRFINISGGKNNNLSLDEFVEILNRDTKNATHGFQTKDSIVQHSKEFPHLVHAVKHFDAMCEVKKRKGFHKLPSYKEDVKKVLIDLLSINGLEVRPGRTLHCRKIVQKSSNPFSDCFVGLPVMIARHKPELPFRRLRNKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EA89</accession>
    <name>A0ABY7EA89_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="103" mass="12004" checksum="03D75FF92CCE613E" modified="2025-10-08" version="1">MPFCMINSGICSIATDRQASRRTQQHKCFMCNGKVGFTGHHVEKGGLGMEQDKLYKICITNIKVDPQKKTWDDSDLTSPNNYKLTAFVNWMEYFKYEHTRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAB6</accession>
    <name>A0ABY7EAB6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guided entry of tail-anchored proteins factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tail-anchored protein insertion receptor WRB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Tryptophan-rich basic protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_016940</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WRB/GET1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="52"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR06982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="128" mass="14898" checksum="1D8BD8F74B6A47E8" modified="2025-10-08" version="1" fragment="single">MKVRCRFLPAFGKLLLLSSKMLTMFLVFLIVLFFSYLPSYSSKISRTFGGYFIRLTDEELNLRQQVRDLKAEQGAVSMSEEFAKYMKLQRKIDKLVEQVKKMGSSRSSKITMFSMGVKFLINILHPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECS4</accession>
    <name>A0ABY7ECS4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DLL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_016654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045504822" evidence="6">
        <location>
            <begin position="19"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR06696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="178" mass="19166" checksum="2EF22315F5AC38BC" modified="2025-10-08" version="1" fragment="single">MFARLTLVCFLHVFKVEALNTSCCDSYHVKRQNGELWTCGNCPPGYHFVDDCDFNGGRAKCSSCSEATAEGDTKCVRCPEGTISPNNSSEEKCMPDTDDCALMPCMNNGTCTDLVDDFKCTCPGGISGRRCEHATSCDNGPCQNGGRCVPEGILHICDCPDGFKGKNCEETIPSSKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDC8</accession>
    <name>A0ABY7EDC8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_017990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="8">
        <location>
            <begin position="104"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR08032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="309" mass="34780" checksum="A4E16B6DF0E657D1" modified="2025-10-08" version="1">MNSAGKRMWGSRKTSTSSLFPSNWLIRARWLAKDLYPNPSRNAPRSPISNTRMVDTPLSRKSWAMSNTAATMSFGTDVVVISLPPKLTTTKSAPYIFTCFKSPEVQFRFYTTKDVRALSVKEITNVETFDTLNHPTVGGLYDQALGPSDEHDVCFTCNQPSLHCPGHMGHMELAMPVFNPLLFMTMLQDRSEDRSQHKQLIEETAKQCLQGKSPEQDKNSHSYKNVEAVRQSISSIFTKVQMRKNKKCAHCLAKRKTLRHEDRSKIFLVGTLADAPKEKGKTKVTNNQTGDDPEDDGDDEEEGDNSDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDV7</accession>
    <name>A0ABY7EDV7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_018168</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045465669" evidence="3">
        <location>
            <begin position="19"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR08210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="463" mass="49795" checksum="4ED277FB2E550391" modified="2025-10-08" version="1" fragment="single">MWSIWFIVAQAIPGIILGQVCPPELPVASMCVAGTVRGSSVALDISGAAGNGAETCTCAALATSSGVTVDIIAALKDVNCGTTLSILFKEKSIKTICGGSATHVSTGNSAFITYTRNLLIENPNSNYCITFASDRNDTTFTLTCTTPPTTTTKLPTQPQNTTISAQPETTISPGHQNITTTLGSLTTLSPPSTSVVILVPLLAVVLIGFVAVATYIMCKRRNDSLLNTTQNGKPKAYEPNDRERDLMASLELSTINFESDPSDTNRYFKKEDPGDWYRVVMKGKKPKSSKSARKYKSNDKDHGKGKHRHRSRTKESSGHRSKRRSKSRSDSDGDYLASDSSNAKKSKSSTATSDSLKDSYSSKFGGTQSNEDRTESQAENRKDSKSMSSNPRLIQSQPVPVIHSKPVSEPKFVQSQSANKTRTLPQQRPTTLESKPKEPEPPKARVILSSSGPTNVPTAVPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEU2</accession>
    <name>A0ABY7EEU2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045818948" evidence="1">
        <location>
            <begin position="17"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="61" mass="6559" checksum="0F4BFAF17A989329" modified="2025-10-08" version="1" fragment="single">MSLCVFLLYFIVTSNAEDVSYRETGCYGDASGDSDNRLVASCSTGRIYINDILVGTKPASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEY2</accession>
    <name>A0ABY7EEY2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8242" checksum="3A4EE25D81E2BB3E" modified="2025-10-08" version="1" fragment="single">MADKLSHVSSFSVKEMCEWVDSISKDLATIFKENDIDGQGLLAVVEDDTLFKELVPKLVLRAKLKQGLFSEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EF76</accession>
    <name>A0ABY7EF76_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="356" mass="40629" checksum="ACCAD1E4B46A02D4" modified="2025-10-08" version="1" fragment="single">HCLHKHIPTHPEISGRRRGIIPRAPKPIGTTTHQLAPQYNYQLAPQHINWHNNTSTGTTTYQLAQQHINWHNNTSTGTTTHQLAPQHINWHHNISTGTTTHQLAQQHINWHNNKSTGTTTYQLAQQHINWHNNTSTGTTTHQLAQQHINWHHNISTGTTTHQLAQQHINWHNNTSTGTTTHQLRGKYVVSTVKQEKIPVINGAPKFSAGLGYQLKIKQLEEENRYLVTAIADVADGDSVALQKCKSYSYYLNNDADDGTTVLNNVNETTTRYAVFWSSDVDHYTLMLRCFIKEGLPEPRTCKVEDTAISLFVPDTLDNLKWSKVLKDLEETDVEFGNERFEWFFNFNYGKSTCVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EG10</accession>
    <name>A0ABY7EG10_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">FAT4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_017556</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052459">
        <property type="entry name" value="TNFRSF_decoy_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23097:SF181">
        <property type="entry name" value="CASPASE-8-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23097">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045818950" evidence="10">
        <location>
            <begin position="20"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="9">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="12">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="200"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR07598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="242" mass="26433" checksum="D64B93D9045FA425" modified="2025-10-08" version="1">MLVPLALVVWFLYVSLVIGLNTSCCDSYHLKRQNGELWTCDNCPPGYHFVDDCEFNGGSAKCSPCSNGYYMEARNVLRACRKCKSTCPNYTIINFNCTSTLDLQCGCSYDKYLDKDVCVAKTKCQPGFGVSEITAEGDTKCVTCPEGTISPNLSFDEKCMPDTEDCVPMPCMNNGACTDLVDDLNCICPAAFSGRRCEHDTDDCVPVPCMNNGTCTDLVDGFICICQAGFSGRSCEHGKPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EH88</accession>
    <name>A0ABY7EH88_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="94"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="270"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="313"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="443"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="626" mass="65763" checksum="BE87C96C6A549166" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHT8</accession>
    <name>A0ABY7EHT8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BIR7A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_018465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16510">
        <property type="entry name" value="RING-HC_IAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="226"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR08507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="267" mass="29021" checksum="2E81501858B560C3" modified="2025-10-08" version="1" fragment="single">MATPSKQKHDTAKPTPASLGISTMKPKFQQYALPSKRLDSFIEASVPWPESSPVKVEDMVAAGLVYTGVGDSVRCYHCGGGLRNWEPGDVPMEQHAKWYPTCQHVLITKGKTYIHNVKHSSSDNSAQQQQQEAMQAAAEFGYSEENINIAACLFRERNGNGATSKFKGADLVSILMEMEDDPDLALNANVLGSCSPTKPSDNTEIEGDDLQSLVLENENLKALFNCKICLDNRADVIFLPCGHIVSCPQCAPALDICPVCSKSIMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIN8</accession>
    <name>A0ABY7EIN8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1241"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1439"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1241"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1382"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1446"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1464"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1474"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1494"/>
            <end position="1507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1507" mass="170518" checksum="84D5190F335DC22B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJA0</accession>
    <name>A0ABY7EJA0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PTPRB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_018960</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0768">Sushi</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="118"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="348"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="451"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="12">
        <location>
            <begin position="741"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="13">
        <location>
            <begin position="861"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="952"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="952"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="964"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="978"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR09002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="988" mass="111159" checksum="E555D8919615F595" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKG4</accession>
    <name>A0ABY7EKG4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_035551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF4">
        <property type="entry name" value="CHORION PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047076737" description="Peroxidase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR10475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="65736" checksum="37982102300CD83F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EL36</accession>
    <name>A0ABY7EL36_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="64003" checksum="C965D78DBC2DCE73" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQT9</accession>
    <name>A0ABY7EQT9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TTPAL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF130">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="98"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="317" mass="36376" checksum="8AB32279773DE1B3" modified="2025-10-08" version="1">MGDGCAYTCGLDGASEQKAARELNEEPRERLGALTAFREWALQQRWLKTPTDVRYLLGFLRARKFSQLGARELLENYWTVRTKYADWYKDLDPADNHVQDIIKQGVYIPLPGRDKQGRKLVIVRLGSMDPKGKRNTFDDVMRANLALFDYILLDENIQVNGLVFIIDLTGFSRHHFVSTGVENTRKCMIVTQKALPGRIKELHYYNTGPVFESIFNMIRPMMSEKLRNRVHVHGQNLSTVYGRIDQTLLPEEYLPDDYEGTCAGSIQDICNNLAEEMRQPQARDFIRDLHSGKYGVDLALKPDTVEPQASFRKLNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERS0</accession>
    <name>A0ABY7ERS0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GSTA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_025601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="40"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR11421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="227" mass="26429" checksum="6066D40FBC384F51" modified="2025-10-08" version="1">MRVSYIRSLGTFTLLKVQHNSYRSTINLKAQIRTQAMSNQQMFLWWGSGSCPCWKPMIVLAEKGLWKGLPNKLISFDEEEYRCSDILAINPRGQVPTFKDGELVVNESNAICMYLEEKYSTAENRLLPETPEQRSTVYWKIFEASNVEIKVLDALAYYFYYTKKEDRNDEVIKEKVATAKTELSHWEKDYPALRKYYDTITARPSVQATWPPHWREGPTAENHLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESJ6</accession>
    <name>A0ABY7ESJ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RIT2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_026087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF6">
        <property type="entry name" value="RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR11907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="376" mass="42777" checksum="2154AD38BD46034B" modified="2025-10-08" version="1">MDPDKVEQKFSVPTIRHEVSYDVKTDHEDHEEPTIADKNQLFQRRMELRDSEHVAQNHSNLKSNNTPWTSFRNRPRPKHLNVGVGRPRRSSLPSTSGNFLSESFDDIHNQKESDQQPLRRVRPFKITSKGGIVNRGDSFKRSSNSINSIQSAIHSEHGGTRSYNNSMHTINRTQSRERGTLDSTGSSIETVIHKVAMVGDKGVGKTSLTNQFMTSEFIAFDADNDDDKTGSFVTVLLNSEESTLKIEMSSQSVDAFAVVYSVTDRSSYQEAVDIMYHVRHQLVIKDKPAILIANKIDLVRKRKVTREDELLVRILSQIRLYKTPGQPIDPSNFDVRPCQNKHAKCFIPVPKRLLNFIFCKSPIPTARHECEDLFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESR6</accession>
    <name>A0ABY7ESR6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="229" mass="26422" checksum="44909269C8A1BE26" modified="2025-10-08" version="1" fragment="single">MGTVYAFIKRITECLKNKHPGITYVHYITDSSTSHYRNKNTMYLVANHVRLFVFESGSRLRTSNGLGGFSKRFADLAVKRQTASAEDYYNWGKSLANSQTKYSFVPNEECDEAYNELLAVNPRVHCNCIVYFRWECLTDGKFKASCNGCIKHNIVQHIGKSNETDMRTDIQNEPEVILDQARRFESVTSFTENEFVAVIYNDYLYIGKVVKYDHSDDELPLQDSFMEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EY31</accession>
    <name>A0ABY7EY31_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR14848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="160" mass="17772" checksum="4A15C5EDA3328D36" modified="2025-10-08" version="1">MATKSTNENNTLEQLSLCHDGRGHRAGFFVEMVVVTERSEDKSHIRHVFQCGPWLDSHNDNCHMETMLRMIGCSCTVTVKTSEGKRTATTGKVQITMYGTSGHTAALLLSSLEPGTLAFTSGVKSEFHISTGQIKRASWGNTREREFKTKNTKGCAFKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EYQ5</accession>
    <name>A0ABY7EYQ5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-amylase</fullName>
            <ecNumber evidence="5">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_005168</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd11317">
        <property type="entry name" value="AmyAc_bac_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045307579" description="alpha-amylase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="15">
        <location>
            <begin position="34"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-amylase C-terminal" evidence="14">
        <location>
            <begin position="415"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR15063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="512" mass="56460" checksum="F151A44D8AA27279" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EYW8</accession>
    <name>A0ABY7EYW8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPTP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF43">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="210" mass="24193" checksum="6B7C7004206193CA" modified="2025-10-08" version="1">MAAESDHFCLQRLYDLFYACHAEDGTICLENYVTAYYEISKLLKLMGTVFGFVKSDVDEKIEILQEFRKSDIGDKYKTIQGMIEYEVETKTTNNKKKASGARTLLRLHRALEFIVDLFKALKESGEHDKMSAITSKSYYRTLSKHHPWLIRKGVDVAVYTLPSRKHFIEKLKISDMSQAEKLLESTAALGHKIFDVVEQAYTDNKLHDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2G3</accession>
    <name>A0ABY7F2G3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ANGP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF394">
        <property type="entry name" value="ANGIOPOIETIN-RELATED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="163"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="382" mass="42920" checksum="C2E9B701F225B41F" modified="2025-10-08" version="1">MAYMKDIAMSRPLPYNSVRKACFSVPFIRDVFNLNVHLNKLFAICDVNKLRMNYRFTKEMELSSDVYTFAIAYKVLVIKNELNAIKSSMNQLQAKIYTGKKVATSTSSIVVVSLLQCQYMCFLARSKGTCNICEFDKVSNTCVFSSDTEHDIIRTPDDTKVVLIPDEGTNDCYGLHKQDQGLPSGVYEFSLSRFHVKVPVFCDMTTAGGGWTVIQHRYDGSVDFYRTISEYTDGFGNVGMEFWLGLSYIKEIADKGNTTIRMEISAADGNSSYEEWPEFRLGDAPTYTLHVGGLGTGTAGDYARYFARHNNGSDFTAKGSFCGDDMHGGWWYNDCTEINLNGEYVTPGTRSGYAGGWGGMVYPSFRYWSSLKTSTIMIRRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F384</accession>
    <name>A0ABY7F384_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PRP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="253" mass="28844" checksum="31C2216A0CA88ECD" modified="2025-10-08" version="1">MPYKFTICSIRHKITTQSSPVRHALKQSLLVKHALKQPRLVRHALKQSSSVRHPLKQSSLVRHAFKQSPLVRHAFKQSPLVRHAFKQSPLVRHALKQSPLVRHALKQSPLSRAIIIVGTRPKTIVVERRYLEQSPLLRQVRKQSPLVRHALKQSPLLRKVLKQSPFVRHALKQPPLLRRALKQSPLVRHALKQSPLLLYPKKKPPLVRHALKQSSLVRNALKKTPLSKTIIISPTSPKTITIGSTRPKTITVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3I3</accession>
    <name>A0ABY7F3I3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPN4B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_004006</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd14969">
        <property type="entry name" value="7tmA_Opsins_type2_animals"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="48"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR13901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="468" mass="51913" checksum="9BBA7F12F456BF22" modified="2025-10-08" version="1">MSFNESDIPDNPYKGLTFLEVKRIQYPVWGHQIVGGFLLLVLIGGFMENLLIMFIFWKNKELLSSTNIFILAVAIGDFGMACLGVPLPVIGALNGKWFMGEFLCKWQAFVVYFVGLSQMYLLMAVSVDRYVVITKPHLAHRITKKVAMACVAVCYGLAIFLALMPLIGWSSYGLEASGVFCGLRWEDHSARNTSYNIVIFFFCYFGPIGVMIFSYYHLFMAVLCGYSDSIPLVLTEIPGATAKSQIVWNPIIYAVSHKVPGSRKQEGSHKQAGSHEQAGSHKQAVTHKQEGSHEQEGSHKQEGSHKQAGFHKQAVSQKQEGSHKQAGSHKQAVTHKQEGSHKQEGSHTQEGSHKQDGSHKQAVSYEQTVFHKQEGSHKQEGSHPQKGSHKQAVSHEQTVSHKQEGSHKQEGSHPQKGSHKQEGSHKQAVSHEQQCPTNRKGPTNRKGPTTRWCPTNRKGPTNGQGPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F514</accession>
    <name>A0ABY7F514_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 11">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_031479</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3 11"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd01570">
        <property type="entry name" value="NAPRTase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041619">
        <property type="entry name" value="NAPRTase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17956">
        <property type="entry name" value="NAPRTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="12">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="353"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR16885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="424" mass="47481" checksum="C45B4BB5F0AFF6A7" modified="2025-10-08" version="1">MKDLYQITMSYAYWKSGKMNDYAVFDLYFRRNPFKGEFTMFAGLEEVIKFLKNFHFSDSDIAYLKTVLPAYTEEEFFVYLRNLSAKDVTLHAIEEGTVVFPKEPLIVIEGPLPIVQLMETPLLVATNGMRFRLAAGPDKTLLEFGLRRAQGPDGALSASRYCYLGGFDGTSNVLAGKLYGIPVKGTHAHAFVTSYTTLEDLQFKMLVPKDSTEPVDFVEVCIKWQKKLVGVIDFIPDQVSTGELAAFISYAQAFPNGFLALIDTYDVIRSGLPNFCTVTMALSELGYQALGIRLDSGDLSYLSQIVRDTFRKVAIANVASTLPQRKASHLVEVNSKARIKLSEDVEKVTIPGKKFAYRLYGQDGNALVDLMVKPDEPPPQANSRVLCRHPFQESKRAYVIPAKVECLHKTCWKNGKKYGSISVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F6A6</accession>
    <name>A0ABY7F6A6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR17718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="696" mass="80100" checksum="AC52DA352C74D709" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F6F7</accession>
    <name>A0ABY7F6F7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="97" mass="10904" checksum="AB1B08B1B9EF425E" modified="2025-10-08" version="1">MSRSTSNGNACEMGRRSESAKASFVWTSAGTNFFSTAFDVQARTREFARNWGQNILEKGIVAQNSKKEQGLFTMNFVPTLRNMCQLLSTTMRMEGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9N2</accession>
    <name>A0ABY7F9N2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SC5A8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_000613</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR18775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="157" mass="17610" checksum="9FC7D86D97FB87E7" modified="2025-10-08" version="1">MSSTDNQTFHVVVYIIMVLFLVISTTIGLYFGFYKKQRTTEEYLLGGRKMNLLPVALSLVVTFHTMTNYMFVAIMIANAIQALVLVPLLYPLRLTSTYELLYMAIVLLAPALALEAVAGIPLWLSVIVVGIIGTFYTSIGGLRTVIWTDVFQFIKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FA36</accession>
    <name>A0ABY7FA36_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030737</name>
        <name evidence="2" type="ORF">MAR_030775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="106" mass="11703" checksum="2D65B8BD546B7DA9" modified="2025-10-08" version="1">MSAWGAGSRVSVTSSAQLNIDSTQNDPVGGDISLDGNAILIKTHEAIYYWDASRSHDYIALLQQPGDKVPYIHEHQGESVCWDATDSGYYTLGEGKNEPLYHYVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBA2</accession>
    <name>A0ABY7FBA2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDC42-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_000467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR18629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="209" mass="23849" checksum="B50D82E1D0053F83" modified="2025-10-08" version="1">MNGCHRLNPPRTDYIKCVVVGDGAVGKTCMLVSYATNKFPSEYVPTVFDNYAGQMFREADVPLLPCSETRAYRNEDYDRLRVLAYPDTDVFVVCFSVVAPTSFENVEEKWAPEVHHYREDTPFILVGTQVDLRDNFYELQRLQKNRQKPVTYEMGIRLANRIGANCYVECSALTQKGLKAVFDNAILAVINPQPVTRRPKKRTALCKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FC31</accession>
    <name>A0ABY7FC31_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="60" mass="7309" checksum="AC68C61E514320B1" modified="2025-10-08" version="1">MDKCMNVTAYLWRYFLCDSWCKMMVVVVLKWDMTMWMYWCRVLGITTATLRELSVVLFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCM6</accession>
    <name>A0ABY7FCM6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_001778</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR19940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="93" mass="10860" checksum="E89C4D860AFFC157" modified="2025-10-08" version="1">MPKICSYGGCTCNHIQKENISFFKFPDSVKEAERRAKWARACGRQNSDGSKWKPMAKYVYICSQHFINVKGQKRMDRFNSAKRQILNNNDRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDH5</accession>
    <name>A0ABY7FDH5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SVEP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_000859</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46967">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN,N-TERMINAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46967:SF2">
        <property type="entry name" value="SUSHI, VON WILLEBRAND FACTOR TYPE A, EGF AND PENTRAXIN DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045111404" evidence="8">
        <location>
            <begin position="25"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1551"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="10">
        <location>
            <begin position="125"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="216"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="10">
        <location>
            <begin position="531"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="601"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="667"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1184"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1642"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1829"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2027"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="352"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1650"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1841"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1857"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2027"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="603"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1193"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1212"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR19021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2066" mass="226931" checksum="2DF90D0B20B0B0B9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDI5</accession>
    <name>A0ABY7FDI5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="169" mass="18176" checksum="1413F4582920F9A1" modified="2025-10-08" version="1">MELCVMGNCAIVAADESGYICAIQPSQELWRINLNNLAINKGPSEKAIVTSLLCADLTTPSGEVCSYILAADNRKHLLVVNQGEVVMTINTPDVVTAMCSGAFIDAERLDTGGETTQTKNTTQKVGNYDTPDWIRTMDIMYTSGERKPQIVIGCLNNSVQGLSLLEGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FF10</accession>
    <name>A0ABY7FF10_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NGB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_001572</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00188">
        <property type="entry name" value="PLANTGLOBIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="22"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR19734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="185" mass="21425" checksum="38EC4E119066121F" modified="2025-10-08" version="1" fragment="single">MGNKMPSCAIPYPNRDKQLHMVLSTEQVRLVQGSWELLKDELGRLGLIVFLRLFETEPQMKTIFPKIVQMNRDNKLEENIDKDMLQRHAVTVMEGLGAAVESLDDSIILNSVLISIGQTHVQRQVKPHMVKKLWPSLNYGLKEVLEEYYTRNVAEAWKRVYDYICVYMKMGMENPDIDPDITSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FG05</accession>
    <name>A0ABY7FG05_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GNPAT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_001785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF17">
        <property type="entry name" value="DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="127"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR19947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="322" mass="37290" checksum="3C2983B0D15A5907" modified="2025-10-08" version="1" fragment="single">DPRLVSARQKDFFVDILDERRHTSDFAWSLRHRDVPTYKYNKPRSPADVKQDVLQSDRTVEETGQPYEFVVKEAEYIVDEMSHNLRVGVVRCFALVLVKVMKKLFERIYVNEEAIQNVRAMLKDYPILLMPSHRSYLDFLLMSYVFYHYDLPLPVIAAAMDFMGMKFFGWLLRNSGAFYIRRSFGDDQLYWAVFTEYVQTHICNGDSPIEFYVEGTRSRTQKSLPPRIGMLSASLEPYFKANVPDIMVVPISISYDRVLEERLYAYELLGVPKPKESASGVFKARSILSEDFGNVHIFIGAPRSIRTFSVSEVDRTAHSTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHD0</accession>
    <name>A0ABY7FHD0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPTC2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002372</name>
        <name evidence="3" type="ORF">MAR_002412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR20574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="441" mass="49419" checksum="2EE49EED0E905A21" modified="2025-10-08" version="1" fragment="single">MENNIVSDFERLRVFSSSIGKMDDLVHDLSMALEDAASHKRSKSDGGHGASSSSTRRHPRKRRGRRKRHQPDNGNFSETSQSSIDEALKDYMENCAQSDSDDLTIAHHIVRLTMPLSINYVPTQVESDSVNESLFSPIRPQRRRKKYKTMAIDPDPSSSQHDSPIQGKPKFSRPRSKTMELPRCSMGTSPMDGGGFPQINKEGVTEDTVPGKRKRNSRKTDFQADDCFNKDDDSVQDSTMNSQESSSSTISSSCSSDSVSGDEYCVTAEADDEQSDFFHESGPASGIPGVIPWWENDGVNSGDETMVSDKHFQQILTGSFQHLSRSSQVGFKARMTRIMRHCGREIRFGRRKLRGKIPGYTVQHFIQERHKWNSIQGKLASRFTSPTGVPTSNTLTDSKRQRKTPPPIFADGLEPRAGPWYRRDGYQDPRFGQYQAPQAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHI5</accession>
    <name>A0ABY7FHI5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF3">
        <property type="entry name" value="PROTEIN HU-LI TAI SHAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="100" mass="11219" checksum="CAF7EED9ED35C4BA" modified="2025-10-08" version="1">MSNEAFTADASEGKKGRADPDDEQYQKNLRRPAEVKEDIKQMSDRSRVSLILNSEAFRRELEEIVDEQLRQGNAPASLLALQQISNLLLPNHNAASYSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FII1</accession>
    <name>A0ABY7FII1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">IDE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_014821</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="68"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="232"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="10">
        <location>
            <begin position="384"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="10">
        <location>
            <begin position="473"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="11">
        <location>
            <begin position="693"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR20847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="848" mass="97841" checksum="51A0E81B300ABFA8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIL2</accession>
    <name>A0ABY7FIL2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HARB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_015904</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF292">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="134"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR21930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="289" mass="32771" checksum="6D5A3BC180F1CFC9" modified="2025-10-08" version="1" fragment="single">MTDLFTALLIEELSDADDMQTINNDTFHSSHNKFCCTRSIQDLCKTVWPLMVKNRSITVQKRLLATLWLLNNQESHRGVADRFGALHLTVMETCQVLFMLMSDLIQFPRTIHYMKDATEGFMARCGFPGGVGAIDGTHIPIPTPTIEHRASFINRKEFASMILQVVCDSNLEFLDVYTGCPGSVHDARKQIHTLPEEFQVLGDSAYPLSKYVLFLYRDNGHLDNTEKKFNKCHTSTRVDVERFIEELQVVISSCCVLYNLISNHENDSNIDADPVDDGVEEQAYNGQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMY0</accession>
    <name>A0ABY7FMY0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="209" mass="24404" checksum="306B3516DBD2FD5C" modified="2025-10-08" version="1">MTGKRVLPHAHYGDMSRSRSIGSKFSESENVQQEITTTQLQLCYKQLYNIYGHYFKCIFHNIRSLKCHKDELFAEPNILAADIISCLNNRNVSMADLVMMMGKYNVHPEEVDTVSRGPPESRYFEVSLRSRDIVERFIGYTDFSYRDNNNLRLSWARSWMRKNEMSRQERAREVKDVTEAMQETGKAGEEEETEGDDNGEVDVWSEAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNX6</accession>
    <name>A0ABY7FNX6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OX1R-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_036391</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="193"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR22722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="287" mass="32258" checksum="C3679F11F3EA58E9" modified="2025-10-08" version="1">MKRCQQKAVMAVSKRCRVGTINHYPVISQLGRYRIYSSIYMFLDTPMDIVNKAQFDIILYLFRRVTKTYPSKVPTQAAIPVRQPPTALPVVANAGAGELGGINIAEIFGDFDRRDPLLWNTQPLCNRSGFYQGFNVSPFEHPSQVFVNECLGHQHCMTVSECSKRIDKHVTPGLVEWFIIALYSVILILGLVGNGLVCFVVVRTSHMRTVVNIFIVNLAVADFLVLLVCLPPSVLADTTESWYLGDIMCKVVPFLQRQFDVTRNPIKLPGIQSLRDQNVPNLRFPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPL3</accession>
    <name>A0ABY7FPL3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NKX32-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_016630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF73">
        <property type="entry name" value="HOMEOBOX PROTEIN BAGPIPE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="108"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR22656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="224" mass="25462" checksum="33C6C2EC2E7B419E" modified="2025-10-08" version="1">MSVSDTDETNEQGVSIEYDSDGGRNDGDDTSANVKDTKHATEDKSTEVKDAVIRQSVEGTGELMDVEEGKKNSNIVSRSKPIFRKEVQADVNTTASITSLRESSKPRKKRSRAAFSHAQVFELERRFRHQRYLSGPERADLANALKLTETQVKIWFQNRRYKTKRKQMQRDQALTGSSKTASVTILVKDGKRLYDAEEMIRPMFYPPAIPLTPYGLSIYVIPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQM9</accession>
    <name>A0ABY7FQM9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_038192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20562" checksum="503BE56C02B84813" modified="2025-10-08" version="1">MKSKYLKSILETRQVIRITGHFARCNSRTFVNWVLTSDDSDSEIVLEFLWPLLTDAFKTNVGDVEGEGLKFVGIGDRHFRPGYGIMDEVNKCFNDTAVILAAVSNAFCESVFCKNELEYAIILKKPVVLLFLEQIPEESMPACVRQLFNKNVRVKIEMKDDEIKVTPHVDDVCSAIFSLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQX7</accession>
    <name>A0ABY7FQX7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MCPH1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_038294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd17736">
        <property type="entry name" value="BRCT_microcephalin_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17751">
        <property type="entry name" value="BRCT_microcephalin_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022047">
        <property type="entry name" value="Microcephalin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625:SF3">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="1122"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR24625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1217" mass="136401" checksum="E53EC067CC0E24EA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSH4</accession>
    <name>A0ABY7FSH4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR25168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="124" mass="13851" checksum="2CB90B6A1B2F6CF0" modified="2025-10-08" version="1">MDVFLAFLVAICDVRYGMFDWVTGLLFTNGMAVIVEKNSSRANPLEFNLDMRTGTFSQLDLLSAEESSSALTEVFLTIKSALSCSVPWEMARVILVAMPQFLRKPTWLKAKLQGLRSKLVDGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSV9</accession>
    <name>A0ABY7FSV9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_037640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047234206" evidence="2">
        <location>
            <begin position="20"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR23971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="296" mass="30993" checksum="E5E0ED2A4E2F2332" modified="2025-10-08" version="1">MYLLGLILTVMVSTTTTTASTSTPTTTGTRSPTSVITTTSTPTTTGTSSSTSVITTTSTPTTTGTSSSTSVITTTSNPITTGSSNSTSEITTTSTSTTTGSNNSTTEITTTSTLTTTWTSSSTSEITTTSTPITTGTSSSTSEITTTSAPIIPGTTSSTKVSTTTSAVDNTSTNNPDNGADMKDIEYIAPFMPENKFNTSTLRPNERQCVQLLRDGGRNGTWVPYNCSDPGDGKTGYICEHKCGTDWSFENLKAVEYRITDTTRPSTKQTSPLSTTMQTQSGVTYEDNEAECLKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSY1</accession>
    <name>A0ABY7FSY1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFHA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_038058</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF61">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN LRRA-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="3">
        <location>
            <begin position="78"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR24389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="320" mass="36959" checksum="A6370A51C486419B" modified="2025-10-08" version="1">MIRSSRMSFYDKEILKELRLLVETTDPLYRGQKKLKLRGKDLQSVPQVLFTMMDLEVLDLSPARESCLAFRLPLVPPSIGKLINLKVLQLDTNELRSLPKEISLLHSLERLSLSNNFLDTLPHGIARLKKLRSIHMANNRFEAFPLEVCEIESLEFLDLSDNHLVSIPESISKLDNLRTLLLCYNKIIQLPESLCDLAYLECLWLGHNRLKSLPQHFHKLRRIEWGLRYSSSVLEYNPLVHPPIEICRLGPAKIKEYFDDLNAVREINTPDFEKDEYHANETESELGEITADTPIEDVMKNFKIKVTSPDGIEDEIKAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTA1</accession>
    <name>A0ABY7FTA1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TRISR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_038496</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF224">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR24827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="321" mass="37354" checksum="23FD0377F51743D7" modified="2025-10-08" version="1">MTNVFLANLAIADISVGIFCVLPNLSTFLQHDWVLGRVMCKIYYYIWNVSYIASIIILTVIAMERYIVIMHPLRAKHSLTNQRLAIVQCVMWSIALLYNIPYIILYDTISFGDSEFCYASSRSTFYLKCLSLVNVIVWYFLPLVLIGFLYYKVARVLSPHTSNDLCNRNSRSYCRQSSPKLEVDRKQSFRSSSDGPEETMELNLLGRIGDSKSKGTTYQKRQQALRRRSVFKSHRVTRERRKVIRLLIAVVVSFAVCVLPHNLKVIDHYWMIFSLSNDVMLIFSPVSFIILFMNSVLNPFLYAMFSTNFRKSFRDSIVCWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTM8</accession>
    <name>A0ABY7FTM8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR24962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="132" mass="14585" checksum="9CB33FFF702E7DB6" modified="2025-10-08" version="1">MLPVRACFSEKDTTTHGHTTTTTPQGISCTVCNNVLPLCFQLHHVASCPEPYCINEVTNTADGSKTIIRRCGTLHECNTEWWGKTSDDPDCQTYNPNGNVNKYIHCTFCCTTENCNADVVPKPGTLYTPPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUF3</accession>
    <name>A0ABY7FUF3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZN836-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_038356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR24687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="483" mass="55444" checksum="5418B3F57E50069A" modified="2025-10-08" version="1">MFEVNVSSTKELCMVTMQHLRTNGHVCSVCGKLCQSKFSLDMHMRIHTGEKPFKCTVCGKMFRQKGALKVTYIICNPNFITLLTLLFYYFSENLPGKVCSACGKMFQSKFSLEMHMRTHTGERPFTCNLCENIQAKACSVCGKLFPSKYGLDLHMRIHTGEKPFNCIVCGKRFSQKCSMERHLVIEKIFFFLAEDLQAKACSVCGKLFPSKYGLDMHMRIHTGEKPFICSVCGKSFSQKGTLKAHVFCKHQTIREGVKIYACNWCGKMFSSGSLLRRHHVVHTGEKPYVCDICHRGFTQKSDMMNHKKVQHFSKNVFVFSGKSGTQCDLCMKIFRGPFHLRRHMVVHTGEKPFTCDICQRATRNRKVYKCGNCKKTFSSPADVRRHMVVHTGEKPFIICVLKKQTVTGQNLMKKIIINTIAGLKLYNCARCNRRFPSPAKLKTHMVVHTREKPFKCRICLKTFTQTSSLYKHQRQLHGFSFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUH3</accession>
    <name>A0ABY7FUH3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sema domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF70">
        <property type="entry name" value="PLEXIN A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046801243" description="Sema domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="2">
        <location>
            <begin position="34"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="357" mass="40667" checksum="B448CDD9BF26B230" modified="2025-10-08" version="1">MEGFRRCTTILLTLAILAAVIESETEIVRRGKELSKIVPYNGSFYIADGNEVYKLNSRFDEVERANLSEHGSNDNTVTLILVDDKNNSLIVCGPFGVVCKCIHLDSLEEQFTSDDIVVQQNASHLQGIIIQKEEKSLLNLAVSLKHPEESLKMIEQFVIENHFQKAKNRYVQLKRPVQIDYRAVFQFGHHIFFFTNQQQTINDEVYISKISRVCKDGFFTFVDLQLRCNGYESYNLVQDAILINQKTLFVTFVEGQKTEEIQSDHGILCLADFEVINKTMTKEQKRVIDCENWDENTYLKNECLPNVTLSVEHIRLGNDALFCQVGGDKVSPVERQGQTMKCPIVGKTGTLIVVVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWQ4</accession>
    <name>A0ABY7FWQ4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="75" mass="8659" checksum="366C3BC74D2C8429" modified="2025-10-08" version="1" fragment="single">YCRCDFLRTGGRQLRVPGPFPAGAHKPPRVFPAAGDYWRCVQWRCSSPDYICRLRCLLQHVQTAQVRPSNPYHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZH2</accession>
    <name>A0ABY7FZH2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F120A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026784">
        <property type="entry name" value="Coact_PPARg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15976:SF16">
        <property type="entry name" value="ASTEROID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15976">
        <property type="entry name" value="CONSTITUTIVE COACTIVATOR OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="510" mass="56566" checksum="AF90F2180085220D" modified="2025-10-08" version="1">MPHPDSGNVPDPPCPRSEIWENGELKYRNSTKSSKVELVAKLRQRVYSITSMEQKKVFFDTNQDQHITRGVGGKEVELPPVSTDIMRIASERHQKGMMSPWVYQLLTQAEIKMVVSLEDEGNRELPTSMDLFRPIRQTVYSVLLNLNKLKIIHDNQLQETVKEWVVRRVGSQKPSFDLVMARPVDWKTPSIERMWLGQQPDDKTRRLRAFLTCMHSDTPLMLNTNYVPQHLLVLCCVLRYMLEYGRILQRQELDAFLAMSVSPLLEDVQTMQDLKLPSVNPRGVALAALFMSGVEVAQFANDVCGAPVPWNMICPWQFFDGKLFHFKLLKAKNNTPLVDMCDGQGGRGMNMNYMGPPEMGGPPNPQGRGRGILGRSPVDGRGGQLEIAGVVVGSWGPNLSGSSRGRGGNGPLQPRVMSVGGGQRGGDGLDKEDDGSDEGEDENFEDAEDETEDDNGAIGPGRSGWSRKRDGHGLGEASRSSPNRPPKPSRGLPQLAGVILVAALRFVHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZJ4</accession>
    <name>A0ABY7FZJ4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="120" mass="13204" checksum="23EED70BE846BDA6" modified="2025-10-08" version="1">MCLLIVSLFNHCVGRFISFRTSVNLTYCTMGHKIIIVMVALSTLPLVTGQLPDKPKLMECKSCNDCDDYLPDGSAVECSGSCFTYKVYKKGCLTSGGITMKWDQEGCYNMDVSSYIGEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0M3</accession>
    <name>A0ABY7G0M3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PCCB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta" evidence="1">
        <location>
            <begin position="28"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta" evidence="1">
        <location>
            <begin position="196"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="256" mass="28448" checksum="00E7693D2ABAA8CA" modified="2025-10-08" version="1">MDNNHDLTNLKHPLKYITSLAEWFLPTTPGVAHRAFENDVDGLLQLREFFDFLPLSNQDPAPIRDCYDPWDRMVPGLDTVVPLETTAAYDIVDVITGVADDSHFFEIMPAYAKNIVVGFARMNGRTVGIVGNQPKVAAGCLDINASVKGARFVRFCDSFNIPIAYGGAYDVMSSKHLRGDTNYAWPTAEVAVMGAKAKNEAEYVEKFANPFPAAVRGFVDDIIEPRTTRKQICQDLDVLASKKLVNPWKKHANMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G198</accession>
    <name>A0ABY7G198_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="32" mass="3488" checksum="9983D147152045E1" modified="2025-10-08" version="1">MTIPADQLASGVSCCFNVAEWSNFLVELKADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2E6</accession>
    <name>A0ABY7G2E6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HARB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_014316</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF286">
        <property type="entry name" value="NUCLEASE HARBI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="180"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR28612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="353" mass="40335" checksum="F0DF84237BC66FEA" modified="2025-10-08" version="1">MKKIYIHKGCKQLPCGQFQGVCGTCKNTIYNSILEPLLISYKKQEKDMVMMERRPNLDDLTNIEIIDRYRLDRDGIDYVENILSRQITPKAYRNHAISARHKLLITLRYLATGPIQLNDCDIHGVSQPTVSRVLGEMLNVLSDPRLVRQFISFPTDAADLRRNATIFEGIANFPKVMGLIDGTHIRIRAPSEDEYMYVNRNTQHVQVVVDGEDKIIDIVARWPGSVHDARILRESGLSQLLDNGFGGHEQFHLLGDSGYLKATKNKIQGRESHWTAEEEIWCAPYRDYPFTRKACKVVIACAVLHNLCIARGIPFADNQDDDNGNNNNGDPRPQDQMPGLRYRDYYAATYFHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8A4</accession>
    <name>A0ABY7G8A4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IFI44-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFI44 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241:SF32">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR29774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="463" mass="51247" checksum="CC3C70122589F26B" modified="2025-10-08" version="1" fragment="single">MAGRLTEKQKDQLETWIGSGPKTFKLIYNITRVECSAQEFHRTCDNQGPTVTVLYNPEGSVYGGYAGISWQSNGGYMEDESAFIFQLMYSGKLVLNTFRPKDASKALRFQAQDGPCFGCPDLLTFTGDVAMSVEGYFCLNGRVSLNNYYKDKSVPNTNINNGHTKTAEIEVYSINDVKLRPETKAFISTKKTQCTGYIWRNALDLTDETVKSLCQEIREVRPKTGTDVTDFRLLLIGPIGAGKSSFINTAMSAFTSRVMHKAPVGTSETGLTKQFIPYQVCETDGSLLHFRLCDTPGLGETSSMDAINLHFLLDGHIPPSFEFSSSRHVSAKTVGYISKPALAQEIHSVALVLDASTVNGMSSTDTSLLNYCKRLILEKAIPFVVILTKIDKLHEEIADNLTDVFKRPEVNQAVEKVSEALGIPPNHVFPVKNHYREVETEMSVNALSLMALRKMVLLASDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8E0</accession>
    <name>A0ABY7G8E0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATS12-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_003387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF53">
        <property type="entry name" value="HEMICENTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C1q" evidence="4">
        <location>
            <begin position="76"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR29819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="156" mass="17085" checksum="22EF59F5E7318009" modified="2025-10-08" version="1">MKYKNQSHLPQPWNGQVDYCAGHGGWSDWESWSACPVTCDVGLRSRQRFCNNPFPSMLGQYCQGKSDDYTVCNTKPCKSEVAFNAHLGLSVTVNKGDKVVFDSVLLNSGDCYNASTGIFAAPLSGIHNASHTTETPQHASKNGIHNTEKRKEATNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAG6</accession>
    <name>A0ABY7GAG6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPXM2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="122" mass="13818" checksum="BCBF5A77BBA87797" modified="2025-10-08" version="1">MRRFSGLWNVHLDTVQFNGLSRVVGVAVQGRPFNTDPTVAYMDCCYHRVTSYKFLYSWDCQHFTTVKDPNGSDMIFAGNTDQDTVVTSMLPKQVSAVCVRINPVTWEGFIALRFDILGCQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GB77</accession>
    <name>A0ABY7GB77_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF56">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="2">
        <location>
            <begin position="4"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="2">
        <location>
            <begin position="148"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR30226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="297" mass="32398" checksum="48FB035DC5E23F16" modified="2025-10-08" version="1">MSTSAEFENPEVFKEAQASVRNDSSEDMFVIVSHVDNDPAKLQVLKVGQNVEEIRDYMDSQQVMYVLARYKSTYDMSTTVKLGEDVAFTKKGKFAVVHGSVRERFNPYHLSIETGSVDDFQEEKIQQQLEENTGKKSKVLESTEGHQMRGFTATELPKRGPAPKSGPQVSSQGAVIDIEEDVLEAIAQVRAGSPKGPLVLTGSGEGDSGEILEVLAEDKPMYALYRTTDVVDAITIVKVGNAVKPMTKAKISTHKGSLEKAFGPFHVAIFASDESEISEKAIVEKVSSASGTKSFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GC63</accession>
    <name>A0ABY7GC63_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_033462</name>
        <name evidence="2" type="ORF">MAR_033466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="13344" checksum="7DB73E96E84D6E75" modified="2025-10-08" version="1">MGEELDDMIDDIEFLMTMVKECNEKLSAIALRPNPLSMTDHIDLMIENEKLLKKDKFIGRIKTLNEFRKKALIMSDATKITKEAQTAMRKARVKKKRDTPGVMKRIGTWFKQIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBS2</accession>
    <name>A0ABY7DBS2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_007593</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045740375" description="ATP-dependent DNA helicase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="164"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="4">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ95122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="501" mass="56532" checksum="BCB699E91A9F05DF" modified="2025-10-08" version="1">MFTLLLLLLPHHSEIDLVGKYGCAKDAFSAKHSLLDFSMDMHNTFLLQVENKMIRLRLAEAELEEQNDILTSGYIDINTHTLSPVANLYTHTYNDFFTETLHFHQTSACSLSEAEFELSCQKLTDCQRNALLAVKKHISDQSCGAVDKYLNYAGLTAFQLRSLQNQFVGVYTIVIDVVSMVSDRMFTFISRRLCEITGNSSPFGGLNIILFGDFFQIKPVCGSFVFHNKVLWELFFPVFLRQNLRQSQDIQYINLLNRDRVGMLNRDDIVLLKSRLDIALSHPSSLCIFPTRSSVREHNQQCLQRLGLNVYKVTAEHYFSTDDSNAGEPCDIVFIPEDDRDAGSLPHHLDISNQSRVMLLRNLDISRGLVNGATGIVQNILLDSLGHVQQINVIFDEPVNNMVAIETMEHKFVYAGRSIVRRSFPLSLCWASTIHTLQGLSTSSCSLDLGSSVFQPGMAYVALSSVTHLTGLHLLRFNPDVVTANETVLEEYNRLHDLAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DC43</accession>
    <name>A0ABY7DC43_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="134" mass="14645" checksum="F33F6F7085AA5C26" modified="2025-10-08" version="1">MAAREEKKRNQGGMRFVGEVNGGESGHDMSRHALYKKGFSSNAVMNVIEKVGCGIEGIGVAESFDATCIHERTYQPLSECAEMAIAAPSTQSCIGTNPPSSHCSCHECGSIRRLKKRKLELEVAILAKRFEKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFT7</accession>
    <name>A0ABY7DFT7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_028828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ96138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="138" mass="15927" checksum="26C5662FB7F5A68F" modified="2025-10-08" version="1">MICMAKEFDVDRPVVTKYHATSFGRGKIHQTEIYELKMKKLDIILLLISGWNDICLFQTLQDAGVFLKLTQSGILFTLNVRQEKKRWNELETPDVSKADVEKDPFKDNAGQLYSVAIRVLKKSTMRNITESFAEVKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DI49</accession>
    <name>A0ABY7DI49_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="812"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1376"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="830"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="915"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="962"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1324"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1376"/>
            <end position="1397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1713" mass="194032" checksum="EF024B5C5A6290E0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLF4</accession>
    <name>A0ABY7DLF4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ADPGK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_022154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007666">
        <property type="entry name" value="ADP_PFK/GK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208">
        <property type="entry name" value="ADP-DEPENDENT GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208:SF0">
        <property type="entry name" value="ADP-DEPENDENT GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04587">
        <property type="entry name" value="ADP_PFK_GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51255">
        <property type="entry name" value="ADPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ97781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="458" mass="50957" checksum="64357FA36F71FFDA" modified="2025-10-08" version="1" fragment="single">MLSKSIFLGLLVIVFAYLYTKWKECLAENQEESIILFWNSSIREPTDQFSHIAVGINCNLDLIVSGVALLSSLEKGRGQPLDSVALESIDDLANTFTYYFSKGSAAERTFKSKEIYAAIIETAEKLEEKEHYIGGNAALMAVNIAELFPNKKIQLIGPIGPVLKKLLPHNVLVPDDSLIDKDEVHLIMEYGLHEAWQGLESPVANRFITSYDESNSRLTMLNKFFKDLGPFSPNLVLVSGLHLLETQSLTYMSDKLEEFKTGLQNIPQSIPVHLELASMADEGAVKLIIDEVSSLGLNEQELTFSSYVANGPHSSYYHSRNGQPEIYKISDMVLWLLKTYGYSSKNPRSRLTRVHFHSLTYHIIGSLPDAWLNSESAVGAGTRMAGRQACKVDRLSPPDIELRIPQSFQLFSGSDAVTFNESKPVVSWKREGFQFVFSPVLVCINPLKTVGLGDAISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPF9</accession>
    <name>A0ABY7DPF9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAXC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_022618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026928">
        <property type="entry name" value="FAX/IsoI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01200">
        <property type="entry name" value="SUF1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="2">
        <location>
            <begin position="43"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ98245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="254" mass="29959" checksum="0BA3B7BE622C6A7B" modified="2025-10-08" version="1">MSGAEDTSPNEPHPQWKPEYKRDHVYLHVIPRDRAKGALNISPFAIKLEFWLRINKIPFETIDSEQFSSKKQSPFILFNGEEIPDSNFIVEFLCKKFKKDPYPGLGPIERATSRAFLKMTEENMTWPIFVYRYVEHTDEYADYFFPTVPREQRLKILETLTDWVGKRAYGHGIGRHASADIQKIGCDDIQAISDYLADKNFIMGDTPSLVAYVPMKYPMRIYLFDKCPNIIRFLNRMRDNYWPEWPRLEESKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPV6</accession>
    <name>A0ABY7DPV6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHSTF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_022501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052654">
        <property type="entry name" value="CS_Sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15723">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15723:SF0">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="2">
        <location>
            <begin position="198"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ98128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="379" mass="43571" checksum="4483B2199C235495" modified="2025-10-08" version="1" fragment="single">SNGNTILKPAIAQRNETPKKEDHQPKSEVKTQKEAPMKSNQQLTTGDLPLPYMRNQFDIRRFEPKLPAKLTGLTPLKPGIPESSEFPGMPDPCAAPRRYVCAMCGTFALCAVRVSYVRYVCAMCGTCELCARLHLHPDIVPNRGIFGKEIWYWSWKRFWISHGDPMDIWDRFLESNTPQNSPGAEELLWTTPYAAKHINPNVKLLLMLRDPVDRLYSHYFHGGYGNSAQSFHEHVSASVPLWYECTSKHTIRHCIYDDKFRKSLKAPIYTSFYIVHLLEWLKVFPREQLFVFRNEDYTSDIRATISSICRFLDIAQPSEPTLKSMAGLGAFYATAKKQAAGPMLLESRKLLVDLYRPYTEELARFLGDERFGFRDKSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQM3</accession>
    <name>A0ABY7DQM3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLXA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_023390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF70">
        <property type="entry name" value="PLEXIN A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sema" evidence="2">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ99017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="358" mass="40033" checksum="258F4C756A886FE0" modified="2025-10-08" version="1" fragment="single">MYYNSQDKVSKLARICQRDASYQTYIDAEIACQVRGESYNVLTDATFVNGTVFASFSKPDGPFESVICFKDIRQLNSSLVDEKLDFINGSCVLDNDLSYLDNFGKLPKCDDPKNYTEFILPEFTCAANMTDVSSYKGVIGKTQINFNYSVHNIYGKITKLFTTTVNEKLVLLAGTEDGHVIQFSIFEDGSLHEYDTSSVLVGTSKEDNQIHDLYHFPDGDALYALTKSKISKISARSCNESGVSVCVESETMKLKDPHCGWCVFTNKLSKMSECKDKWISSVDGLGNLLATISEEAGLLQKNREDAINFKSCLCTPDVTSTIIVAFKMDKDLAFRSWYSKLTVTKTSKIGIKNYLNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQW6</accession>
    <name>A0ABY7DQW6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PHX2B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_024469</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="34"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="36"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="99"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR00097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="209" mass="24080" checksum="A3FD8D48A94B99BB" modified="2025-10-08" version="1">MANYISTYNLFQSQGLSYKMYQHGHESGISPEKRKQRRIRTTFTSAQLKELEKAFSETHYPDIYTREEIAMRTDLTEARVQVWFQNRRAKFRKMERAKQQQSSQPQSPTVKQENTSSVNNNTNNSNNNNNNNNNNTQKEKPKPMEDQREKSPIDNQKWSSPMNNANKMTSSMLGVPSLPGPYSSILSSNVSEYPQNGMDSKLPISAPMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRG7</accession>
    <name>A0ABY7DRG7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="124" mass="13692" checksum="E04E52BC71DC4FB8" modified="2025-10-08" version="1">MSSATYETKLQIQDTRMKKTLLTGKRSLTKEANIVFINFHKEEVNELIAQTKKPTVFKTEGKTISNTSKSEEDFILTYLPDCVISGMTTVNDVTLPDIPTSVGMHNTEGRVVGPPQFASSPTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRV5</accession>
    <name>A0ABY7DRV5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="93" mass="10652" checksum="1CD64F0D23C7A544" modified="2025-10-08" version="1">MTRAGWCRFPRDTTTGHPHTHQHLQADIIPVQLSPLLSRANPRSHVQVKLPWVFLHWPLVQIPGISRHSLMSARKSGQGSHSWLQARPTEQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSM8</accession>
    <name>A0ABY7DSM8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AF4/FMR2 family member lilli</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Protein lilliputian</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_024281</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Has a role in transcriptional regulation. Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth. Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate. Required specifically for the microtubule-based basal transport of lipid droplets. Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye. Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007797">
        <property type="entry name" value="AF4/FMR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043640">
        <property type="entry name" value="AF4/FMR2_CHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10528">
        <property type="entry name" value="AF4/FMR2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10528:SF17">
        <property type="entry name" value="AF4_FMR2 FAMILY MEMBER LILLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18876">
        <property type="entry name" value="AFF4_CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0562">Pair-rule protein</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AF4/FMR2 C-terminal homology" evidence="14">
        <location>
            <begin position="995"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="domain" description="AF4/FMR2 C-terminal homology" evidence="14">
        <location>
            <begin position="1133"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="42"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="185"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="493"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="660"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="522"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="663"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="748"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="782"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="839"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="853"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="894"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="960"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAQ99908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1215" mass="134028" checksum="BEC22891E5312CB7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DT68</accession>
    <name>A0ABY7DT68_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ACH92-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="1">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="62" mass="7313" checksum="B1557CB3CB729976" modified="2025-10-08" version="1">MLSGERLATYFNGCHIRNLSASIWHDERISWRKEDYNGLEVVRLPARLLWLPDIVLYNKLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DT88</accession>
    <name>A0ABY7DT88_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ShKT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_024202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055471">
        <property type="entry name" value="DUF7043"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23070">
        <property type="entry name" value="DUF7043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ99829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="276" mass="32005" checksum="0164EF2FA529BD93" modified="2025-10-08" version="1" fragment="single">KAATAHLYNSVVFCSNRQPSFVCMQFVKRSETVIQVLEVSRFHCWAGWEEKKYKFLVVGEDDGVPQYCLRFPREVGEQFTVLVYFSVLCPLREDGKPPTGIEYHEMNMQTLVDRCVDDDIERCEAVKARGQCKKEEKYAMHCERSCDKCVEQSQLLDILCPFPSSVQGSWLFLDVRHKEQVRVNQTTVAFERLGSFTCKERSFTSHKLFKTVTLFNNGCSMRYTCFEFYRRTENVLQFRIGTSARGDTGFENLCKFEDGASPLNDLYRGSKPRNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUQ5</accession>
    <name>A0ABY7DUQ5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="76" mass="8652" checksum="E62BB16492BA40AF" modified="2025-10-08" version="1">MEDNVKDAPRTANAVVNGSDEDKTDSFVHITMPDEMQKEYEETLSTGGRGDFCSAEEDQLRVEPLAKYSYTVCYHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUS7</accession>
    <name>A0ABY7DUS7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_008031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045701178" evidence="2">
        <location>
            <begin position="18"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR01473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="305" mass="33783" checksum="22C489E0CC2C55EF" modified="2025-10-08" version="1" fragment="single">MRHGGLATPLMIGGIAAAFTGTATSTGAGFVGQYISSNKINDVQKILDADNQLIKEIEDKKAVVDVKVLELSKVLHLSEHEVFGALLMSSLPRIRGFVRMDNITVFQLVVSTGLVGMLHLSFQSGSIAVKGMGAFAVVSLKGLSKVLGAMAKGSPSRAADSLTEIAIQLEKQADDVETSLKIIMEEVKQYEMEVESFRTLLETVALQDSATDEQAKVIARFIRNHSSSEWWSAFLSLDVDLQEFAFKIANVFLNFIKLIENYQKEDEQKKKKKKERRRIRKMRPEKLPHLNITLIAHGGIDPRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUT5</accession>
    <name>A0ABY7DUT5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KLH13-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_024974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="37"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR00602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="666" mass="77120" checksum="8A482987CCD8F747" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DV91</accession>
    <name>A0ABY7DV91_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_024978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1015"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1153"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="970"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1068"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1207"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1290"/>
            <end position="1320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR00606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1515" mass="174135" checksum="2ED1F3DAD01C65DF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DW53</accession>
    <name>A0ABY7DW53_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CO6A4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_024913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd01472">
        <property type="entry name" value="vWA_collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045661943" evidence="2">
        <location>
            <begin position="25"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="207"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="407"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="464"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="464"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR00541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="553" mass="60877" checksum="6A6138E1BFE17B99" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWE2</accession>
    <name>A0ABY7DWE2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SIAE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_008590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd09275">
        <property type="entry name" value="RNase_HI_RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039329">
        <property type="entry name" value="SIAE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22901">
        <property type="entry name" value="SIALATE O-ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22901:SF0">
        <property type="entry name" value="SIALATE O-ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03629">
        <property type="entry name" value="SASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046722607" evidence="3">
        <location>
            <begin position="22"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="Sialate O-acetylesterase" evidence="4">
        <location>
            <begin position="107"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR02032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="944" mass="104449" checksum="2AA977757BEA1DFD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DY69</accession>
    <name>A0ABY7DY69_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">F234B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_009003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055409">
        <property type="entry name" value="Beta-prop_FAM234A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045232">
        <property type="entry name" value="FAM234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419:SF30">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23727">
        <property type="entry name" value="Beta-prop_FAM234A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="FAM234A/B beta-propeller" evidence="7">
        <location>
            <begin position="302"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="649"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR02445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="814" mass="91483" checksum="4CFBF415A58BDD67" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E083</accession>
    <name>A0ABY7E083_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_009970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR03412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="102" mass="11927" checksum="1F156A5D8FE7242B" modified="2025-10-08" version="1">MLVDWYTGTWTGTIVALFEVISISWVYGTYDNYPSTPHPSNITILSVFIQRISSLCRPTDTWGPCGDGMDCNYRTNIIKYSERTFWDLFYFNVFGRFQRTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0J7</accession>
    <name>A0ABY7E0J7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_009024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR02466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="64" mass="7606" checksum="D0F0FBC0E0960F5F" modified="2025-10-08" version="1" fragment="single">MTRAFARQRFNSLGQMTRMSVLLRIVLPLLQRVMRIQIQNVKLTCAFVRQSLSWQMTRLSVLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E118</accession>
    <name>A0ABY7E118_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DERM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_009437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dermatopontin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026645">
        <property type="entry name" value="Dermatopontin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15040:SF1">
        <property type="entry name" value="DERMATOPONTIN-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15040">
        <property type="entry name" value="DERMATOPONTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14704">
        <property type="entry name" value="DERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046565708" evidence="5">
        <location>
            <begin position="20"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR02879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="171" mass="19720" checksum="F0856E692266DE47" modified="2025-10-08" version="1" fragment="single">MFVLFSLVLILGSCRHAAAYVNALDAEFSFSCGTSEQTISHVESVHDNHAEDRQFDFSCRDVMAEMDGTKAACYWTGYANVFDQPENFQCPGNQYVNGMGSQHNNHYEDRIWKFRCCSLPDVNCIIVIQIFCNVLDTSKIRDILNQTYLVCVILLYKWQNNQQRNQITHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1X2</accession>
    <name>A0ABY7E1X2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CHIA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_010566</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR04008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="5">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR04008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="235" mass="27097" checksum="82A4B7E37FA7757D" modified="2025-10-08" version="1" fragment="single">NKLKNFCYFTNWSPSLANFEARFDVENINATLCSHLIYAFANIDVVELKIVKSEIGDDNGSLTNKQGRYFEFNKLKIRNSELVTLLSISGTNGKGWFQVVASETSMQTFAQNVAIFLRDRDFDGIDLDWEYPLELYRNKFTQLLQYSVFTITIDSACATALQVFRRQFENEAMQTSKPRLLISIAVGVSEYTISKSYNIPQISRFETLYRNMFTEYGNGGLSDVLYCFPLHTKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2Y6</accession>
    <name>A0ABY7E2Y6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MLX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_019739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF25">
        <property type="entry name" value="MAX-LIKE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR04370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="272" mass="30282" checksum="6B0EA06FA71723D0" modified="2025-10-08" version="1" fragment="single">TVDPSDLVDYWACLLPLPLRPPHWSVSPGQGQVTLASLLCQAMRVLPLSHWLLQSPQVQQLKWSSEINVLTVRTEVYSYCFRIKNVSAYEQKYSFVTVLDGDNLKYSVTMSGSPTNATQFVFGRAGSTGSIPGSSASSAHNTDDEDSDGNKTTLSYKDRYDELQAIVPTCQQSDAMAPSKLSKATKKKQEDELDSLRKEVMALKIMKANYEHIVKTHQNQPSHGQNQVSDAVKFHVVMDALFQTFNANISVANFAELSACVFSWLEEHCKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E330</accession>
    <name>A0ABY7E330_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MT12B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_019629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF238">
        <property type="entry name" value="SD10469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR04260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="580" mass="62422" checksum="CDB03511B55D82D0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3R2</accession>
    <name>A0ABY7E3R2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NR1D1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_010020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF473">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="162"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR03462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="628" mass="70541" checksum="6927E36A05D116FF" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E404</accession>
    <name>A0ABY7E404_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TLC3B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_009682</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF66">
        <property type="entry name" value="BCDNA.GH12326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR03124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="178" mass="21018" checksum="B88E0FBB5A615195" modified="2025-10-08" version="1" fragment="single">FWLTKAYAWFGLPYFIYDTWAIYNTHYYLNEPYMSSAAWKSKTVHFFKGNTAMIFHHVMLPLIFFPTILFLREDKGDYFVGLFYMVEAAIPFISLRFILAQLQFKDSAVYIISGLLMILVFFLARVCVFPFLYWKYSVFSGIPFLQVPFTLPIKCNIGCLILLVLQVYFLFLMIRGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5A7</accession>
    <name>A0ABY7E5A7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_010541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="77"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR03983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="549" mass="61302" checksum="32FAA7BA7CCD05CB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7K7</accession>
    <name>A0ABY7E7K7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="693" mass="77926" checksum="758E693C0F41819F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8U9</accession>
    <name>A0ABY7E8U9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="192" mass="21576" checksum="B131C7E5A3F57C2F" modified="2025-10-08" version="1">MSGCTLWHIRCLTKVKCPCQIRKSQFIHGYAQFVFEFGYDCILSELPDIVENSMYVPAGHISRKVNNSDADALYAQPNKCKASGSKGAELYAEVNKVAKKKAAGKKRKKTTYENKAYESSTYENHELQETKKQVNKDGLIYADLAFPKQPKGRKPFIHGLDDMTVYADVDLSRKAEPLPDSDDEGSGEKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAK8</accession>
    <name>A0ABY7EAK8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="154" mass="18358" checksum="1AF08E1549A9B54F" modified="2025-10-08" version="1">MAPLTIFERCTVQQHYYINVLDFEYLLIFDKNKQELFIFHIQFSKAKNTFYTFTFVEKSILLFNLLRCFDGMFVRTVTVVCFRVTSEASFEIWLIFLHKAFPSFVLSQVLYVSDFFVKKVLFNDSCVDTDSVKRMFQDFLHSDDSKSNCINKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ED48</accession>
    <name>A0ABY7ED48_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CCD58-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="64" mass="7364" checksum="38E25EBC67B59E05" modified="2025-10-08" version="1">MAAPMVDGTKDFCPCDDIIRFTKTLNKLRQSDDRFIYKLNSMLPTQTFKTRVNPQEECAHLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EE66</accession>
    <name>A0ABY7EE66_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HIN-200 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd04491">
        <property type="entry name" value="SoSSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004021">
        <property type="entry name" value="HIN200/IF120x"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02760">
        <property type="entry name" value="HIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIN-200" evidence="1">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="298" mass="33177" checksum="660F2522317F4074" modified="2025-10-08" version="1">MDLSTLMKSVVGHSPYPKKVTVKVLCTDPATTYVNDKKERRELMNTVVADSTKALKCVVYDSKKSHRFATGSTIILRNIIRKPEGIAVTSATVIFPTAKTLDLPPSIEKEGIAILHPPPADVKSVAEALASPTKTRVSVRGKIVQEEATRYVTVKNEDNVKVKYIYLEDTTKKCKIALWRDLADQPVRPGDYVELSDCITNTFRNEVSLSTTSKTAITKTECPEETVTWEIESVCIEESTATMLLKDDRVVTAPVKSLLEAFPECMEEDLEQYLVSMCNPTMVVKCKFKGSDLLSMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEI6</accession>
    <name>A0ABY7EEI6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_017467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="396"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR07509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="659" mass="73587" checksum="21D4FDC4F0DD19F9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGC5</accession>
    <name>A0ABY7EGC5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PAL2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="64" mass="6921" checksum="DA1E352CD0EF345C" modified="2025-10-08" version="1">MSIAMDQTRQVMGVWGKLLLAQFKEVVNGKLNFGLPANLSGCDINLDFGFKGCDTAMASYMSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGF8</accession>
    <name>A0ABY7EGF8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P52K-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="252"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="334" mass="38357" checksum="2DBD2BDF7595B95A" modified="2025-10-08" version="1">MRKLSSSWLTDHPWLRYSISTDALFCAPCFVFGRKDAKEKTFISTPEDGDDKAGQHLASIMKFDFIIGLVVAEHVMQSTVPLSYLLQAVDCDLLEATRESQTLIRQFQNERADTNVWEALFQSAKDIAAEFEIEPSMPRLAQRQRNRANPPANDPQQYWQRALYFPFLDHLCQELSDRLIVAEERFRAQYLIPSKLNLCTDGMVDLIFAGYSVDLPQGNQSFHNEVRRWKARWQLMDENDKPSTLGETVASTNPDLYKGVYTVLTILLTMPASSATAERSFSVMRRVKTYLRSTMRTERMTGLALMHVYRDVNIDIDQVVSKFAGSKSRRLDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EI61</accession>
    <name>A0ABY7EI61_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase subunit b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_018585</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0138">CF(0)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR08627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="332" mass="37567" checksum="C232918AA0A92F67" modified="2025-10-08" version="1" fragment="single">PRTPISIRPVFVEAGRRVLEGIIRQCRKSACPVYGTTSGLRLETDLAGRNNSQTMLSTLVSKTTLVRPLANLRAIVLARPAATSAVASVESGEENKVKEVYENWDDYPKSVREELPLSEKIHYWKKANEIFFGPQRDVKNFPDFETPDTIKESYNFYMIPSRWFTESLYPRLGVSGCYSLVVLSSLFILNKELVDMHEMTERLTTVIAFGFVLTKLGSMYGVALDKKINIADITTKIDTTKAIPIVYEAKQETLDLQLESQYRQRIQDVYAAVKNRLDYAAAKEAAERKFEQEIMVNWIVDGVKAAITPQSEKQNFMTCIKNLQALSKTATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIE2</accession>
    <name>A0ABY7EIE2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KASH5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028168">
        <property type="entry name" value="KASH5_CC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14662">
        <property type="entry name" value="KASH_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KASH5-like coiled-coil" evidence="2">
        <location>
            <begin position="226"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="368"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="557" mass="64429" checksum="7526CA1E46503DD6" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIN5</accession>
    <name>A0ABY7EIN5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGRD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_016989</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF347">
        <property type="entry name" value="FI21270P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR07031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="548" mass="62293" checksum="66D8F954C56F1434" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIR7</accession>
    <name>A0ABY7EIR7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTBD3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="28"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="436" mass="49748" checksum="634B3C3402AE3064" modified="2025-10-08" version="1">MATKTKDWRSELTASGCLKHLVQEKLFTDVKFIFPNDNNESCTGHKLILSMRSAVFEAMFYGSMSKGDDEVTISDIDKKTFEMVLRYVYTDELEVDGETVLKCLYAAKKYCIDGMVKLCSDVLEASVAVVNVCSNYEHAKLYELQGLHDKCKTFMVKNATEILQDDDFFNLTNESLADYLANGQLKADEALYFVAANRWSENECSKMKIEKSPENKQKVLGPALMEIKFGLLSTKEFEEHVSPTRLLSPEEQDDIYKWIQTKKWPLSDITNKFKSLPRESMTLSLNVDKSNRTESRTLHNNSQFSLKSTKAIQITSVTMRTALYTLSSVKVNAHGKDKVDITLSNICRQRPSTYEFKEPIRLDGNTPVTVSFRFQNATELSASSSLHEPWKTNVLPKNVNHKHYKPFECDHIFGGLIVSCTEYSEFLSTINFKIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELX6</accession>
    <name>A0ABY7ELX6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MSD3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411">
        <property type="entry name" value="APONTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411:SF0">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="189" mass="21976" checksum="B445297A3715000B" modified="2025-10-08" version="1">MNKRIFYTEREISLLKELVTKRVCVIENKKTDFKSIQEKNRAWLDVSKEFNAFPYVYRRNEKQLKKCWQNLKERSKRREETERHERELAYKGRENDPIFVDETDDKSSLASLIVKQNEMGAGGFDGSENRMEDTDEHIPTVAERLHHCRHSSSGPAEDGGSTSFGYNIKAVLEAEVHKYGGVLRTMDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EM11</accession>
    <name>A0ABY7EM11_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="6">PARP</shortName>
            <ecNumber evidence="6">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_034744</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="6"/>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd01341">
        <property type="entry name" value="ADP_ribosyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041400">
        <property type="entry name" value="PARP16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18084">
        <property type="entry name" value="ARTD15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBA" evidence="8">
        <location>
            <begin position="211"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="9">
        <location>
            <begin position="490"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="269"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR09668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="712" mass="80761" checksum="4FD2F2DD48926283" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EM94</accession>
    <name>A0ABY7EM94_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="181" mass="21128" checksum="D91BC688CA5D3B78" modified="2025-10-08" version="1" fragment="single">MTSCDVMFPGSMPDDTVKKHIDVITNAMWYLDGNKQKLTDRAKQSENVAIVPDRFVDNFNDYNDWKKKEQRAPRLQASELKKHSGGIFRLVSMVFTQRWGTFGSDLEQLAVAMDSYAEFLEMSNEQQAKRQKLDHPSRQLGNHSEIQHRIETDTVHKKYTNLDNDLSRQYYTFVSRSTIMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMV0</accession>
    <name>A0ABY7EMV0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">R1AB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_034800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF6">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER M-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="146"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="249"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR09724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="304" mass="34595" checksum="47DA211131BDCA32" modified="2025-10-08" version="1">MWTSIIVSATLVAQDTDVDEGFWLGGTNWEQDAHWIWESTGAELTYQTWGAQQPNNQNGTEHCLSAVKYFDYAWNDAPCDRQIQYDNDLYDDDDDDDDDDDDDDENDDDDYVVDDDDDDDDDDDDNGDVDDDDNDDYDDTDVDEGFWLGGTNWEQDAHWIWESTGAELTYQTWGAQQPNNQNGTEHCLSAVKYFDYSTISDNNLYDDDDDDDDDDDDDDDDDRGDDDDDDDDDDSDLHEFDNTDVDEGFWLGGTNWEQDAHWIWESTGAELTYQTWGAQQPNNQNGTEHCLSAVNSTSGGGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EP60</accession>
    <name>A0ABY7EP60_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="64" mass="7160" checksum="5FD9E413A11912FF" modified="2025-10-08" version="1">MDSTREIYLPYAKSDPPTPSRCRGMMMDFEVGTQWTLGSTPPCIPVGLNEGLYISLDTSYVQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPW5</accession>
    <name>A0ABY7EPW5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="96" mass="10257" checksum="9824311BEC7916EB" modified="2025-10-08" version="1">MKKCSPGNSDVHNGPAHYYEDIAPSSNIGNSDVHNGPAHYYEDIAASSNIGNSDVHNGPAHYYVDIAPSSNIGNSDVHNGPAHYYEDIAASSNKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQ59</accession>
    <name>A0ABY7EQ59_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_036027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="89"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR10951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="212" mass="21014" checksum="F6722FDA93CDFA09" modified="2025-10-08" version="1" fragment="single">AAVSGWTAPGAITGADGSFAILAADAIVEDSPEGTALFTATATVGGTASYVLFDDAGGKGTIDATSGVVSLATGQTLNVATAATHDFIIVATDSKDSTVGSATITLPILNNEAPAYAEAQFTACVEDNSGAAGDTNSDFVYGTDGTLKVATSKTLEKSTMATYTLVLHATDAGPLTGSSTVTLSVESTCSGVEAFGAMFTSVLLSAIVSYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQQ0</accession>
    <name>A0ABY7EQQ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DHGL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_035974</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR10898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="499" mass="56411" checksum="A9C378923B6EBBEA" modified="2025-10-08" version="1" fragment="single">VILYFRYRKTYNRPLWPRGRVLGGSGNINAMQYTRGSPWDYEEWKKAGCDRWDVLPYFIKSEDMQLPEFVSSPFRGKGGPLAMSSGYKSEATQLFIQAGQELGYNRTDYNGYDQEGFGVLQTNIRNGVCSSTSFEYLRKARFRPNLHVSLRSFVTKISFKANRAVGVYFVKNSRKHYISTRKEIILSAGTINSPQLLILSGIGPKTHLQELDIPVVADLPVGENLQDHMGLLMHSKTDKVETLNADLMQSVWAKIKYRLFGTGPLSATSADGSAFLHLDRNKKGHVYPDIQIINIFALLPNIFGFTEATAREIVPVPGKGFTIYILITKPLSRGSIKLRSKDAFDYPLIDPNYLSDTRDVKTLVGGVRIWEKILQTRPYQDMGLKEDEHKMSFCSQHEFRSNAYWECYIRHVAVTAYHLTSTCKMGPENDPSTVVDTQLRVKGIKGLRVVDASIFPNITSGNTNIPTVMVAERAADFIRGVDSVEHIRKRIKSIKIVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERE8</accession>
    <name>A0ABY7ERE8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DDX1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="106" mass="11860" checksum="C2AE9669521BE684" modified="2025-10-08" version="1" fragment="single">DLLKCSKDSLGRIYSQSNRGTQYGPSTFLLSDQNCENMEKISDKGDKMANEVLDLYRCHARGIDVSGLLCDEDKHLDITIDKVEPEMKVPVDEFDGNVTYGQKRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUA7</accession>
    <name>A0ABY7EUA7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TRPM1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_026293</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF12">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="710"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="750"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="831"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="8">
        <location>
            <begin position="632"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR12113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="974" mass="111740" checksum="57C545B6578BF29E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWF7</accession>
    <name>A0ABY7EWF7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045229328" evidence="1">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="64" mass="7099" checksum="67F5D445738E8A11" modified="2025-10-08" version="1">MQFGLVFLVILLCFSVSIFLSLRGDSDLNVHNETSTFWGTLFVGVRSLTEAAPFVEYTCDNGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWL3</accession>
    <name>A0ABY7EWL3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP synthase F0 subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12577" checksum="C11A1DCDEE07CF25" modified="2025-10-08" version="1">MQKSGQNVTALPTYFEVINYLNFAPYFFIAFLLVLTCIVSVPIYCCKKLTWCSSILRVLVFCATILFGSVTRKYKWKLDHLRWTNYKPVFTEQKQQNGDQHLKLRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWT4</accession>
    <name>A0ABY7EWT4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Guanylate-binding protein/Atlastin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1000.10">
        <property type="entry name" value="Guanylate-binding protein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003191">
        <property type="entry name" value="Guanylate-bd/ATL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02841">
        <property type="entry name" value="GBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate-binding protein/Atlastin C-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="193" mass="23143" checksum="7502DF9465C2B001" modified="2025-10-08" version="1" fragment="single">MEMLLFLSQLEEKNDAEKEKHFKDRLFSLKSYDNLQKGLRFKRYEVIGGYKQFKQDLTKVRQNYEKALSDFQQEEIELVWSSFANQLVPVETEILKKDNSLSEIEKKKEKDENAKLMKQREEEMAIETQKALDKQKKELLDEQERLRAERERQYKKGEQKLHEKLINIASLAENKEDETNTLNQIAALEKERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EX27</accession>
    <name>A0ABY7EX27_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="440" mass="50559" checksum="299297FFA04D9E32" modified="2025-10-08" version="1">MAYRTSRASDLRSYQTMASRASDYITLRASRFPDISGYTHNLSLRSAPLDFIDTRPRKKQSTVVTNTFRLADIEELDAAEEKATTISTGYSGYTKIVLLIMRCAVRMMKRLLLRFIASLQMDLNRFLDKYKEELLDTDVGEKYRYILYPTDGGFSNFAKWDMSLLSCVFAEVFRRILVQHVSRVNATFDRFLMRHRISITSTPAGRAYMTVLYPKTGRYSHIRFWNLSLLATVLHKACKDPLHIPSHLFRDIGYIFKLRKELYHYTEPLLGQDDYARYLTSIKGFINRGLVYLNNKPFRKKTLHEAAEIENGLFFQEQGRPAKVPRGQHSVTERIDNIDKMQDTMPFDGGHVVDGAAHAQFVSSTPIQNHTEDEVKDNILGQQRFKNAMNAVRKHGTGRGGKQQVKQKQSDILTKTDSQHSSGTVSEPANKKFTMPKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXJ1</accession>
    <name>A0ABY7EXJ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69360">
        <property type="entry name" value="Cell wall binding repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="113" mass="13133" checksum="C2827D4D4BE60684" modified="2025-10-08" version="1">MDENGIMYKYSMDKNGTDENGVMYTYSMDENGVMYTYSMDENGVMYTYSMDENGVMYTYSMDENGVMHKYSMNENGVMYTFSVDENGVMYTYSMDENGVMYTYSTDESGVMYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXL0</accession>
    <name>A0ABY7EXL0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">15-hydroxyprostaglandin dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="3">1.1.1.141</ecNumber>
            <ecNumber evidence="4">1.1.1.232</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eicosanoid/docosanoid dehydrogenase [NAD(+)]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Prostaglandin dehydrogenase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">MAR_026101</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">MELC-2E11</strain>
            <tissue evidence="23">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78836"/>
            <dbReference type="ChEBI" id="CHEBI:90697"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:48641"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.232"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:23261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90866"/>
            <dbReference type="ChEBI" id="CHEBI:90867"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48953"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NADH + H(+) = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:41596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78325"/>
            <dbReference type="ChEBI" id="CHEBI:78329"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:41597"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67026"/>
            <dbReference type="ChEBI" id="CHEBI:78311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41573"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>prostaglandin A1 + NAD(+) = 15-oxo-prostaglandin A1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41263"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57398"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:85072"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41264"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>prostaglandin E1 + NAD(+) = 15-oxoprostaglandin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16477"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57397"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16478"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57400"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="1.1.1.141"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:11877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>resolvin D1 + NAD(+) = 17-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132081"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:50129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>resolvin D1 + NAD(+) = 8-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50124"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132080"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50125"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>resolvin D2 + NAD(+) = 16-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137498"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:53589"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>resolvin D2 + NAD(+) = 7-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137497"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:53585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>resolvin E1 + NAD(+) = 18-oxo-resolvin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49244"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:91000"/>
            <dbReference type="ChEBI" id="CHEBI:91001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:49245"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 22">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.141" evidence="3"/>
    <dbReference type="EC" id="1.1.1.232" evidence="4"/>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="WAR11921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="277" mass="29008" checksum="7AA6FBF4A6E35F0F" modified="2025-10-08" version="1">MNITDKVALVTGGASGIGQGFVEALLAGGAKVSLLSLQACVIDNNVSIVDYNEEAGRSTEKDLAEKYGSSNVIFCPCNVTSQEQFEEAFRRTREVLGGPDIVVNNAGVGGETDDKWEAVIDINLKGTLRGTRLALRYMSEAGAGSGGVIINMASMAGVNPNPFSPVYGASKAGIIHATRSLAISPDVQKSGIRLNVLCPAFVDTPMFRNMASGDASQTSGSNQAAVKAFVDHIGVMSVEEVAAAFLDLVKDETKNGIILRCAKKTGIQYSTLAVQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXU3</accession>
    <name>A0ABY7EXU3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PCSK4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_027701</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045583555" evidence="6">
        <location>
            <begin position="23"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="130"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="8">
        <location>
            <begin position="457"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR13521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="586" mass="63887" checksum="3ACC62F6679D3949" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXV0</accession>
    <name>A0ABY7EXV0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027429</name>
        <name evidence="3" type="ORF">MAR_027442</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd10229">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="616" mass="68835" checksum="87E8AFA86F32A8B9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F009</accession>
    <name>A0ABY7F009_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGD6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="158" mass="17765" checksum="40FAA93A05C1FFBA" modified="2025-10-08" version="1">MGANGREQDEIRGNGSKLLWEEKEGMVMGGIGGNGSKWELMAAELAHKMGITDFNATSGWFDRFQERSGIHFRWSVCGESYSANDKAKAMKDWDVKLKSMLQNYSPDDIYNTNKTGLFFRMLKAHPKLKTLTNAAKYHKQDSADGPRRNPKPEVTSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3B4</accession>
    <name>A0ABY7F3B4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PSDE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_031266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="45"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR16672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="306" mass="34215" checksum="092FA4B092C85B69" modified="2025-10-08" version="1">MIVLVKDESQPKRIKCDGYTSKEPIDMDRLLRLGGGMHGLGQGAPPSDAPAVDTAEQMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINPNMMVLGQEPRQTTSNLGHLQKPSIQALIHGLNRHYYSIAINYRKNELEQKMLLNLHKKSWADGLTLQDYKTHCTNNESVVKEMLELARNYHKDPKRHLEEHVDVLMTENITQCLGAMLHTVVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3P7</accession>
    <name>A0ABY7F3P7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="158" mass="18601" checksum="AE17F485D0BBFDAF" modified="2025-10-08" version="1">MSKTNLKFRTYKAVFPTALPFRRKGKQDRPNHFSVKLYVPAFKKKKTLLDPKRALYWYLQQTGQFINNIGKSEFNPFIAINRLHRNVPKLIISKWIVIQIAYESDSTLDKVIWDLLVSYTKRHLCSLLSVLEAADGSRETTFVRFHLRNIESSVYTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4J5</accession>
    <name>A0ABY7F4J5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S23A2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_031664</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11119">
        <property type="entry name" value="XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR17070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="614" mass="66832" checksum="C3513F117E21CEC0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F649</accession>
    <name>A0ABY7F649_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="886" mass="96909" checksum="1E2FF927CE76B37F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F6C8</accession>
    <name>A0ABY7F6C8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="286"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR17752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="446" mass="50970" checksum="946B06BECE5325E8" modified="2025-10-08" version="1">MNEAQRSVLQRHLKTLGDNIMLTEELLAAMYQRKLFEWNMIETIKAFDNFIDILKPDYPWLASALESTYKEMDLSLPRQGSMVCVCTCGSLSARESGPLTSRGDTQVDGPYPLPKPLPDIPADTDVKAKVGMFIHKQFGHSKRVSQQDKKSSKPCSVSEEPDMSEKEAITGPVSVADHIHDDLKKIFNKVKDENLSDLLNSEYAHKNAISDSGAGAESGSDEIDANINQNIVDIGKFAEKLEDEIDMLINRMNEMEGLLTQCHYILGDPDRKRRITDLVKDVQYTAKQSEKELRKEKSKSEKMLNELYDYSKQINKLEMKRELMRQENEKLTEEREKLKRENAVIRDKCDKLEVASLQHLEKEKTLQNLKKMVDELKANQFQSTDDSPNFRGIGNTRTNTKRTPRVQNRKGSTVDLSVPGTVRSRTQARGQLFNTRKRTIPINRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F892</accession>
    <name>A0ABY7F892_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Antifreeze protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046015530" description="Antifreeze protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="14597" checksum="C517255D9E942009" modified="2025-10-08" version="1">MNGNLLLVVCLSTLRKLVADIGTPCTVTSDCNTTTVAGTVCDTIMSPPVCKLGSAANCTNNQDDCASNSSCIANACRCTVFTHTEETSTKLCKKDIGQTCAGLTDCLGTACSSTLACDRTANTGVVCDNTNVCKLHEISSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8Y0</accession>
    <name>A0ABY7F8Y0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BAF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_000313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.40">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051387">
        <property type="entry name" value="BAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004122">
        <property type="entry name" value="BAF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036617">
        <property type="entry name" value="BAF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47507">
        <property type="entry name" value="BARRIER TO AUTOINTEGRATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47507:SF6">
        <property type="entry name" value="BARRIER-TO-AUTOINTEGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02961">
        <property type="entry name" value="SAM_BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01023">
        <property type="entry name" value="BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47798">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR18475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="165" mass="17293" checksum="061BD9C05A0E2AAA" modified="2025-10-08" version="1">MTSRVHRDFVKEPMGNKSATALPGIGIVAGRNLSAAGYAKASNVFGKFLALEYGIVNIGSTIASRSIQTAAKKALETAGKGALDTGAKAEAALWPRSPPSLGTSGSVDLTAVFHNVNKECSGDSKWNMSEQSVIADVSRHLKTLHMNVQLKRTPGLGRSTGDIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FER2</accession>
    <name>A0ABY7FER2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1183" mass="129627" checksum="3AC26A3E2FBCC87C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFZ3</accession>
    <name>A0ABY7FFZ3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RHGBA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_002360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042869">
        <property type="entry name" value="ARHGAP11A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15670">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15670:SF4">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="102"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1219"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR20522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1277" mass="140639" checksum="6C36207AE5090569" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGY3</accession>
    <name>A0ABY7FGY3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">COQ8A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_002044</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="7">
        <location>
            <begin position="197"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="7">
        <location>
            <begin position="272"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR20206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="484" mass="53654" checksum="004195529B764736" modified="2025-10-08" version="1">MAGRGDLAGFLRGLGLIRQALSETSGKELRHAWENSSLKSAAEQAGSSLQDITSKGTVKNDSDDPVVKAKARRAIRPKSSLDLAQRKEILSSFKPELSSTSQERKVPSSRIGRVYTFGKMAGSLGLGAMTEFTKQTLGFSGSADKGGKSVVLSEANVNMIVDTLCRVRGAALKLGQMLSLQDESLISPELQKILERVRQSADYMPTWQMERVLKTEFGADWRSKLMSFDDKPFAAASIGQYPGVAQSIDSDINNLMSILSVWNFIPKDLITSNVLTTEYLGMKLLELCLRELFEFRFMQTDPNWSNFFYNPATEQVILLDFGATREFSTKFVDTYIGIIRAAADNDRQGVLEHSRTCGFLTGYETKDMEEAHVDSVMILGEAFHCEGPFDFHNQDTTRRIHSLIPVMMDHRLTPPPEETYSLHRKMAGAFLLCSKLKANVDCRALFEPIYENYKFGVDTNLLSGNGNGETDQAIPADGNLAVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FI30</accession>
    <name>A0ABY7FI30_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="81" mass="8692" checksum="222F09C7AF91D45B" modified="2025-10-08" version="1">MLKECEEDYNVSCTDIMCTHFVLKVVFLQQCHGECKNLATAALPTGKAAPTVMRVTDTQTKQAAGTGLGETSAGVEVLVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIB0</accession>
    <name>A0ABY7FIB0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="91" mass="10230" checksum="DF23BA82891D3390" modified="2025-10-08" version="1">MFDKQGKTVSLHNPKNVVVFNLKDENIRPVTYLRKYITFAATIGVDLKRDKSAKHISQKQVTATAMSDGLKCHLKAINLYNGESVHSSRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIT4</accession>
    <name>A0ABY7FIT4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9318" checksum="B0EBE4F0D4A9FF7E" modified="2025-10-08" version="1" fragment="single">VDVIVNATNQKLDMSVGVVSQQLLKVAGAELQTECTRTGRCEYPSDVVADTLIKSVMEYENDHPDTNIKCVSFVIWSKDVETIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FM79</accession>
    <name>A0ABY7FM79_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 72 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_036911</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="4">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR23242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="295" mass="34145" checksum="EEE66DBE405C7D9E" modified="2025-10-08" version="1">MSGLASTREKRQNAGAKMASLLEAEDEDDFYKTTYGGFNEEEDDREYESEQSESDVDYSDIDIDEADEVRSDMEDDEPKKRKRGAGVSTKAYKEPAPKKPKEDEEKKTKQKTKEKKRTKPPPSIQIYKSSPEKKSLRKSTAERTKEREEREKERELKQRMLKDIAAQKRVAEVRRLTQEELLEEAKITEELNLQSLENYRRLELEKKSRRAIKAKETGPVIRYHSLTMPLIEEVPDDDDELPAKYFDPVTNTPYATLQAFKIIREAYAQQLQNEPPKKSRNSISGEMTGDVAVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMA6</accession>
    <name>A0ABY7FMA6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EXC6B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_016156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="3">
        <location>
            <begin position="126"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="2">
        <location>
            <begin position="339"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="2">
        <location>
            <begin position="415"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR22182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="482" mass="55781" checksum="FEB21F1100EAF1F9" modified="2025-10-08" version="1">MAEATPRKRSNHWKRLDSVQDADSLRQESINAKHEHLITEIETSDGPLATTLRAVYDDDELGKFMDLLVGKIKSHDKEIERMCNYHYQGFIDSVRELLQGEIDATNTALQVSCEPLLHRGDHLIRCRHMYGKLQDQMKEKRFYPALKTLEQLEHTYLPRVSSHWFSQTMAEAIPQLRNRIKEASMSDLKDFLENIRKHSAKIGEVAMGHAAEQNNMDPSIARKREKKKKRAPAPPNPFTGEREDDSDDENKSPALAEHHSVDEEELSAQDLIDFSPVYRCLHIYTVLHESIENYKKYFHDIVGFFVVEDHILSTTQGLVNRAYMDELWETSVSKIVSVLRTNSAPFPKRFPFSEFVPNIYNQVKEYINACLKFSADLHLSHTEIDDMIRKSTNLLLTRTLSGCLTSLIKRPNLSLLQDARSEAEEYIYKKLNNKIDEFLDIASYNWTMMDKVSHPSGYLMDLIAFLQSIFMSFTNLPISQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMD0</accession>
    <name>A0ABY7FMD0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WIF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_016186</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF14">
        <property type="entry name" value="CELL ADHESION MOLECULE DSCAM2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="131"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR22212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="504" mass="55898" checksum="88F43C0F742AA92D" modified="2025-10-08" version="1">MAACFGRWQGHVKFSTELCAAGWDVCSWDVDSSVLGKVSWNVALSVDGCFAYNAAQDGGRCRECQSELDQDDLAGMGRGCPHQHISQGSCISGGRIDASCCVDSHISINTACQQQPWIDGVMCCKQSAKRPHIIVPPPGRLEVNVGRIFMLTCQAEGVPSPRVQWYKDGAKLPNERHSRVSTLLSGDLLVTLSKHSDSGQYTCEVINEEGIDIAHTQVFVKDHDSGCRDDTTDGLLMHRDIHACQGQWKGHVKEGESLCKRGWRVCNHHDKERLKDLSWLDILDMDGCFAYNVANTKRGKCKRCHAGEGRLAGVGRECGRVRYSRPSCLSQGRIDVYRGRDVKNTDDSCSYAEGHTTGVLCCKREKNYRHAKKKDRRKNEISTYERPHCSLGCENGGQCVGYNVCMCPVGYKGAMCQNAVCPSGCGRRARCVRPGVCECIQPYSGKNCSEKPIETRCKLQCLNGGQCRRGACKCPPHYSGSRCQTFTPTWKHHTLLSKQNRTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMR5</accession>
    <name>A0ABY7FMR5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="167" mass="19319" checksum="9898891FFAAAAB76" modified="2025-10-08" version="1">MSKQNQDIQIIQDHDHREDFDGIVQDSLPADEQNCKITAIVEEQERTKDEIDKVGSMHDYENEQNSDEGKELMKLIHKTTQENECANESRVDIETNIVLLAHTYTTEHTIELTEEKAEKESSKEEDSVKVDTRTEHHMNNNRTDNTQNNHDVETAADDKQVNNDQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FP34</accession>
    <name>A0ABY7FP34_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 ubiquitin-protein transferase MAEA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Macrophage erythroblast attacher</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_016422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0265">Erythrocyte maturation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="5">
        <location>
            <begin position="151"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR22448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="292" mass="33893" checksum="A8F06D6FFEF725E9" modified="2025-10-08" version="1">MADIKALEHPTLKVPYELLNKKFRCAQKSIDREVSKVQVVGSELQTCLQKPDITIGEVTLALDSMVEKLKMLKRKADESISEELETARMIKRRVDHLKEAEHLHENTRPLWQKKRLDRMLVEYFLRAGYYSTALKLAQHSDIEDLTNIDLFMNSKAVEESLINHETAPCLAWCYENKSKLRKLKSSLEFKLRQQEFIEMIRSNCRLDAVRHARKYFSSQLDEQQLAETQIVMGLLAFSPDTNIPSYKDLLIQSAGTTWYALEEMAALNEGQVTCPRSKETHHIEKCEKVYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPP8</accession>
    <name>A0ABY7FPP8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR23597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="147" mass="17272" checksum="05F0CB6483136AD9" modified="2025-10-08" version="1" fragment="single">QSQVTCYPHRKLSEFSERIEQLTREYRSYLRKYRELEPGEQHTPWTDKPYSRKQKYADFTHICTDASDTPSKKSRDEFSPLATPVLDVEEADYSYTQLEGLHTHTSHTVPLPVVNLETQDKPLDFNPLLQHNGNYLPLAFERQEQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQB9</accession>
    <name>A0ABY7FQB9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_038006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046094097" evidence="1">
        <location>
            <begin position="17"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="124" mass="14173" checksum="982669FFE9EB3E9D" modified="2025-10-08" version="1">MKLAVLLLSVLGVVQAQSDSVIYDLSSQANCKMVDRSPTYDCRWPAGLDMADLVIESGRIVAYQIQWFNGGWSGWYVSGLNDIDRKFNINAQPTCGMSYTANSMRRMWSYFYDHTHKYLVCRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQH1</accession>
    <name>A0ABY7FQH1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RFA2B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_037078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="7">
        <location>
            <begin position="148"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR23409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="232" mass="24878" checksum="EF46E697AD3DC117" modified="2025-10-08" version="1">MWNNQEGFQAQGGFSSPGGFGTPQADEKRSRQRAQTIVPVTAAEIINSTQQDDKFYSGEIEIYQVSMIGLVRAVKESATRIDYEIDDLTGPPLEVKQSFGGKKSITASKITPVTDMNELTYHILEVVHSHITANAGQTGGGDMGGAVQGMTSMDQGGAGFSDDMVSGLTSIQNQVRMAIKSDGSAEGASVDMVSRQMKGLPEKAIRDAIEFLSSEGHIYSTIDDDHYKATDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRT0</accession>
    <name>A0ABY7FRT0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Tartrate-resistant acid phosphatase type 5</fullName>
            <ecNumber evidence="2 6">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_037956</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2 6"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd07378">
        <property type="entry name" value="MPP_ACP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024927">
        <property type="entry name" value="Acid_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000898">
        <property type="entry name" value="Acid_Ptase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045386830" description="Tartrate-resistant acid phosphatase type 5" evidence="7">
        <location>
            <begin position="17"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR24287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="316" mass="35822" checksum="59105D3A7F8D9F5F" modified="2025-10-08" version="1">MIRFMFMCIFLREVSCMDSLRFLAVGDWGGIPFWPYDTPIETKVAKQMAKVSEMYQSSFNLALGDNFYSNGVTDVDDKRFKETFEDVYHYDSLMNPWYIVAGNHDHYGNASAQIAYTKRNFPDYYYSLNFKIPGGDGVDIIMIDTVLLCGNTDHDIVGDQPHGPENVKVAEDHWAWLDTQLKSSKAEYLLVAGHFPVYSIAEHGPTKCLTNRLKPMLNKYNVTAYFCGHDHNLQHISSSESGWTVDYFVSGAGNIVEDNKSHERDIPAGSLKFFWAKLIDLGGFAVVEATSKNMTMSFVDGFGSTLYSYTMYSRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FT91</accession>
    <name>A0ABY7FT91_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_037707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF63">
        <property type="entry name" value="TICK TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="79"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR24038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="174" mass="19857" checksum="F9A1864D35975270" modified="2025-10-08" version="1">MVNKYSKTQGKFRIGSIIAIFKYISAAETQYECSMSVVIYALYMRLIHILYWPDRDGLRKTMPLQFRKTLGQNIAVIIKCFEVLIQRPKRLARAQTWSSYKPNNTLKNICLSLKGSVLYFVKASSGRASDKWITEHCDRRFDIAERVGMCCATVNIPAFTAGITQLSVADLETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVE7</accession>
    <name>A0ABY7FVE7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[histone H3]-lysine(27) N-trimethyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.356</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_010736</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.356" evidence="1"/>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048358">
        <property type="entry name" value="EZH1/2_MCSS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041343">
        <property type="entry name" value="PRC2_HTH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041355">
        <property type="entry name" value="Pre-SET_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21358">
        <property type="entry name" value="Ezh2_MCSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18118">
        <property type="entry name" value="PRC2_HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18264">
        <property type="entry name" value="preSET_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Tesmin/TSO1-like CXC" evidence="6">
        <location>
            <begin position="476"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="532"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR25032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="642" mass="72373" checksum="258067700FA86315" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FW52</accession>
    <name>A0ABY7FW52_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EFC12-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042847">
        <property type="entry name" value="EFC12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47225">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47225:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="227"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="714" mass="82486" checksum="48CF663BBDC4014D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FW95</accession>
    <name>A0ABY7FW95_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="142" mass="15768" checksum="1A074232EA00ACAC" modified="2025-10-08" version="1" fragment="single">EGEVANESCLPGKRGRSPSPIAPAPKRRRANPEPLTPIRRSKRIQEKKEKSLPIVWALPAPKAERRPSNRRGPQVLPSIEKEKMTPTSRAPPAPRPTSHISELTTGHSGMLSETKKVSSDNKRNSLNPKPSRPLQRSSRILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZF5</accession>
    <name>A0ABY7FZF5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="182" mass="19886" checksum="052EC45BB166F4B7" modified="2025-10-08" version="1">MTTIIIDILALSCNRKPGLSLSNSFKDERRSGEYQYRRTVSDSNTRLPDSSHHMPLTNGPLEEQPSMNGDTPTPTNHSTDSSPNSTIFVPSPGPIPGKTIPNPAQPVVNGPGGDAHKTQPNRSTGSTSSDDDRKRSTPTRTLASSSATSKRDRYVEHNTFNNTPGKHYPNQFTPGKHQHQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G112</accession>
    <name>A0ABY7G112_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR25046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="87" mass="10208" checksum="2A39E6FF7BA168E8" modified="2025-10-08" version="1" fragment="single">LNGFIHPIDLYPSLTFMEREKNVFVNRHYIWLLEILPNSGCVQTFLTNVLTWPKEVNFVADCELALTKAVHIKLINTSVFHCWNYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G259</accession>
    <name>A0ABY7G259_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EBPL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_013696</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF1">
        <property type="entry name" value="EMOPAMIL-BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="8">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR27992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="183" mass="20709" checksum="93BD65208576B788" modified="2025-10-08" version="1">MDFPIAFNSHVTQEGEGDAGIDEGQQRLDGSQLDHIVSALGTITYQRIKKGKEYAKADARWGVSDPTVVSLEILTVTIVEVFVVFTVNGIVQNKPYRHFMQICLCVCELYGGWMTFCPEWLTGSPNLNTSNPLYLWVYLVFYNGLWVVIPCYLLYQSWLAMSHAFSETGEVMSEKQETTIFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3W0</accession>
    <name>A0ABY7G3W0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_002705</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="119"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR29137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="289" mass="32893" checksum="114E16CFFA0D62EF" modified="2025-10-08" version="1" fragment="single">MLVRCNTDLGAELFRSSFLTLSVHHYGCTEETSNGTARTRTGSSKVPVQPVPGGNTRSRREGATEGPQKRKTLVGARYETLMKELEAEHAADFKAFLRMEPQMYYELLNRVGPRITKRDDAFPLRQYMLKPYPHRHLARDERFFNYRCSRARHVVENAFGILANRFRRLLTTLEMRPSTVTKTVMACMTLHNLMRTRYPNIQNADLDREDEQGQFIAGAWRDQAVLEDVQAAGNGSYIYTSRDIRPGYGRVPVEFRPSNGRCPLHRSATGTILSKALSHIGRSSVGVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6N3</accession>
    <name>A0ABY7G6N3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPAM1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_014557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="32"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR28853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="171" mass="20033" checksum="1E320791E06619EF" modified="2025-10-08" version="1">MALHCLQNSDAVPKRETWMTELPSDMGTKFGLGARQFRKGEAPEQDCSWTDNPGDKDKKKDKKKKKEVFVSEADKKAAKEIDKYNKKFRAKSLLEMHQKKIEKKKKKEKKKEKRERKKNKGKEKPKERLMFDRERDLKVNELDEAQRKSLIKRSQELGSRFKSGGTGTSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G761</accession>
    <name>A0ABY7G761_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin maturation protease</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Actin aminopeptidase ACTMAP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_002782</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal N(alpha)-acetyl-L-cysteinyl-L-aspartyl-[protein] + H2O = N-terminal L-aspartyl-[protein] + N-acetyl-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:74579"/>
            <dbReference type="Rhea" id="RHEA-COMP:12669"/>
            <dbReference type="Rhea" id="RHEA-COMP:18395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64720"/>
            <dbReference type="ChEBI" id="CHEBI:78236"/>
            <dbReference type="ChEBI" id="CHEBI:193599"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:74580"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ACTMAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040043">
        <property type="entry name" value="ACTMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28631:SF1">
        <property type="entry name" value="ACTIN MATURATION PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28631">
        <property type="entry name" value="UPF0692 PROTEIN C19ORF54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21646">
        <property type="entry name" value="ACTMAP-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR29214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="406" mass="44162" checksum="E0703C5D1B815C91" modified="2025-10-08" version="1">MAANQDSSSSVEIGSNRCMNSKMSSLSSELDEDSTYSPTLFTPPPLAPVPPPPPFSRTHYHTTTNGIQTDVNNSAISCEPEAEGQRAYTYACSAIPDNLENYVCVSYQRKVEPIIQSGPQCGLVALAMGESILQREVSLDQLTTISQAQGFSKQGEMFSANNMEQLARLAFGCKTSVLDIRDVSGKWEFLNCLARGDILLVPYDPDKNYVPVLKKGFFAAISDDQILTRLQTSSVKKDSEFSNLYHCSIPPLPSNTGRVLPVEPNITPRALSAIVPARPQGAVVSNRAISARTLPAEPPKLHGKENTKLCHSVGNLSSQKTAGAVTTSNSAACRNPLEAASYILVYAKQGKSKYTGIWNAKTLVESCCNLIEIDPQRLRDEENYAFPDKGIEEELCGKVVVLHVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8F8</accession>
    <name>A0ABY7G8F8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Vesicle-trafficking protein SEC22b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">SEC22 vesicle-trafficking protein homolog B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">MAR_033239</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">MELC-2E11</strain>
            <tissue evidence="23">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Golgi apparatus</location>
            <location evidence="16">cis-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="21">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="22">
        <location>
            <begin position="136"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="WAR30697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="217" mass="24834" checksum="A2F85B69DD694230" modified="2025-10-08" version="1">MVIMTMIARVADGLPLAASVQEDEQAGRGMMEYQNQAKQLFRKISSDPQPPARCSLESGPYIFHYFIERGVCYLVLCDKTFSKRLAYSFLEDLQTEFASNFGAKVETVSRPYSFIEFDTYIQKVRKNYMDSRARKNLTSINTELQDVQRIMVQNIDDVLQRGDSLSVLDSKASHLSSMSSKYKKDAKYLNLRASYAKIAAIVAVVVVFLLFIRFWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9A9</accession>
    <name>A0ABY7G9A9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="67" mass="6815" checksum="9D5FC244DDBDB293" modified="2025-10-08" version="1">MTSGGLPGQGGGMYMGMNGDSYTSGGDTSEIATKSEAADSDDGFGSPTYPPQPRQGTNHQGIWFPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GA20</accession>
    <name>A0ABY7GA20_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOT14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="524" mass="57091" checksum="EEA6055AC2ED7935" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAB9</accession>
    <name>A0ABY7GAB9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YAN2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="1">
        <location>
            <begin position="35"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="581" mass="65440" checksum="89BD98CE6E40A6F7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAI0</accession>
    <name>A0ABY7GAI0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="104" mass="11215" checksum="F5F561249968D41E" modified="2025-10-08" version="1">MEKHSKRGDLSNRTSRSDNEGKSASGHERGKKRKGSDVSAEVPKRSRSGAQPGPSAKNGNEKATRSAATTRGINTPRKAPFTYKDDTIKDGGGSTKTEHHRVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GE59</accession>
    <name>A0ABY7GE59_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_033788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241:SF32">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35514" checksum="750E09EA88D76960" modified="2025-10-08" version="1">MFYGCLMHVNIITHSISRVGTVEKVIKLNTWLVYHQQVRLTSPINGPVKMEDIFVQATRHPRVPERKLKRYGASIKILKDIKSLCQRSQQPEVILLVGDVGAGKSSLVNTIIQALTEQHLPRAKTGKGYIPTGTSINYLEEYQRKFGVGKLSRKFNASDPALEVTKIVFVIDAQSSSLPYALIDGIQHHCDLFVVLTKMDVTDQETKLDSTASVRESNASREKRERELAEMLTIEGALNDNLFRWINYNDNITEQNPEIDIIALTSQNPEVVLLLGNVGAGKSSLVNTIIQALTEQHLPRAKTGKGGTLSKTVTLQRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GF03</accession>
    <name>A0ABY7GF03_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="203" mass="22946" checksum="376449A28D10AECD" modified="2025-10-08" version="1" fragment="single">MDVGFASAVANICEQLMKLPSMKDVNIKQLFDTKTAQHSNSPQLRSRPRVKRPPLIPQHHVMGSPLPSPQPRKRSEMYRSTSLETRSRSPSQSHPFIHSMNEYYGGSNLTDRSRSPSPVASPVNTPPRDQPGSYQCLPFNITKSGSINFPRLNTSPTHKPKLNIAPVPQMFLRQRRRRSEKMELRSDSNAPLTNNDSDEDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D9H1</accession>
    <name>A0ABY7D9H1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MOT12-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_006064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="34"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ93593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="483" mass="53153" checksum="0CE10E7C539623E7" modified="2025-10-08" version="1">MDTKSYDGKEGKKDELDIEIQVEESTIDAPDGGWGWLVVLGSFIVQAIQGGLERSNGILYLQMRHHFGQSATDTAWVLSLYSLICRFVGPISSGLCTRYSFRVVTFLGVSLTVAGMLSSGFVPTVQYLYLTYGLVVGVGCSLSYTACILVVGHYFNTRRGIAIGVAASGVGFGCFAWPPVLRALFEYFGFRGAFLIIGAIVSHVYICGMLFMPLIRRKVRIQLHKITPDKDKNETTVTLLSQEIKSKQLNEAISKHCENSSENSKMLSSDSKTAKTEHIPKRRFIDLTLFRNYAFTTMCGQMVLFALSYNLTFVYLPALAKDQGISELEGSYLISITGVFDMIARISMSALLDTKHVKPYRLIAYNLTLFVTAALTVAMPSLHSFFHFAFTCALFGFVSGTYISQLALIMVDILGISNLASAFGLNQLFQGIGMLLGPVIGGLIRDFLGNYYLSFYCGSASTFAAGLLLMTGNIWLRRRGKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAV3</accession>
    <name>A0ABY7DAV3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ93475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="573" mass="61951" checksum="74E68DDCFDB45A59" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFT8</accession>
    <name>A0ABY7DFT8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_028536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ95846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="60" mass="6537" checksum="2D27D5EDF3810819" modified="2025-10-08" version="1">MNNEAKVSARKGVLPCSLPSVQKQESGFPRARSIGKFISRPNIISDGVKPVLLCRLELSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFX6</accession>
    <name>A0ABY7DFX6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WBP11-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_028287</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13361">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13361:SF1">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ95597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="376" mass="42674" checksum="AD84BF02A8F1C09F" modified="2025-10-08" version="1" fragment="single">MGRRSINTTKSGKFMNPTDQARKEARKRELKKNKKQRMMVRTAVLKGKEPLRLLDEMEIIDQMELNPMEAPKLNEKVLKDKRKKLHETFMRVFKLYEKENPEYAKELHKANVDEPHLLSTSPKKKRAPGPPPGPPPELSDSEPEMDEYTHAAEMAAVLAQEVPSEEMEVDAQSGDKKKKIRFIDDESIDPDEEEKDTRLKFKPPKAKVTSLQKRMLEMAGQDIPKIASDSDNSGSSSSSDSDDDDEDRDYRRRRRQEKRERRDKEEDSDSSSESEEETFASHRDESMPPPRMVRPQSGPPSMLASLPLPPGVAPPSLQNPNVISAQPSIMKLPQKAPSEQKKDAATISAKPQIKNPIGDVTRFMPTSLKVKRSAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DH01</accession>
    <name>A0ABY7DH01_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_029627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36162:SF12">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ96937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="439" mass="51904" checksum="2F67A7B685949FFE" modified="2025-10-08" version="1">MAPRQTDWYTITDTETDWYTITDTKTDWYTITDTETDWYTITDTETDWYTITDTETDRYTITDTETEMYTISITDTETDRYTITDTEIDLYTLTDTETDWYTITNPETDRFTITVNDTEWYTITNIATNVYTIIDTDADWYTTNDPATDSNTITDIETVRYTITDTETYRYTITDTETDRFTITYTVINRYAITDVETDWYTITDTETVLYTITDTETDWYTITDTETDWYTINDTETVWYTITYTESDWYTITETKTDWYTITDTETVLYTINDTETDWYTITDTETVLYTINDTETDRYTITESETVWYTITETKTDWYTITDTETVLYTINDTETDWYTITDTETVLYTINDTETVWYTITDTEPDRYTITETKTDKYTIIDTGTDRYTITDTETDWYGITDIETAGVQSLTLRQTGIQSLSPRPSGIQSLNTETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DL49</accession>
    <name>A0ABY7DL49_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RL3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_028395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ95705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="403" mass="45838" checksum="8BD931A7109248F5" modified="2025-10-08" version="1">MSHRKFSAPRHGSKGFLPKKRARRHRGKVKSFPKDNKSAPPHLTAYLGYKAGMTHIVREVDRPGSKSNKKEIVEAVTIIETPPMMVIGCVGYIETPSGLRSFKTIFAEHLSEECRRRFYKNWYASKKKAFKKASQKWQDDAGKKEIERDFVKIKKYCTVVRAICHTQTKLMKKRQKKAHIMEVQVNGGSISDKVDFIRENMEKSVAIKSVFAQDENIDIIGVTKGRGFKGVTSRWNCKKLPRKTHKGLRKVACIGAWHPSRVQFTVARAGQKGYHHRTEINKKIYRIGDGIHQKDGKVVKNNAATEYDPTDKTVTPLGGFPHYGEVNNDFIMIKGCCIGPKKRVLTLRKSLLASHKKRQMEKINLKFIDTSSKFGHGRFQTIEEKKAFMGPLKKDAVKAEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLC4</accession>
    <name>A0ABY7DLC4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_029999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ97309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="101" mass="11117" checksum="FD4574086C650EAA" modified="2025-10-08" version="1" fragment="single">MLRDYHYHCGVRRCQSASCIPPNTTMLSEALMLTQYGTNSSSFHVTSVRPCVTGDCSICSMFRSSISRGRREATTPLSLSRPTTSIFPCPSTAVPRGELRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLF2</accession>
    <name>A0ABY7DLF2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH24B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_029855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14388:SF17">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14388">
        <property type="entry name" value="T CELL-SPECIFIC ADAPTER PROTEIN TSAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="318"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="98"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ97165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="438" mass="52146" checksum="3E26DE67570A0798" modified="2025-10-08" version="1">MLQQILQDMFIEPDLLAELSDEQKQILFLKMREEQIRRWTEKEEKLDQEEKKKPRKPRKPGGKQVDFLLGADGKEWVWVMGDHQGDRSIEEILEEEAHRKAEEQAHKEAEALRLKQEEEIHRKIEEEKRKLEEEKEKEKRRLEEEALYQSIKEARLQAQKAEERNRLEQEERERLKKIQDEAAVERRRSLTKIEDKEKRRSNEIYIRWKEMRRQLDMVAEEASKEVDKNWREQEENRQSITRASQLIINANRLMSGQKPPLPPKTNAVIDKNRQLREEARKLRPARPPNCEAVITWFHQEEKGRKSVIDPNTGRPEEWFHGVISRMDAEKLLLEKPLGSYLVRVSEKVWGYTISYRAIDRCKHFLIDATEEAYHFFGPNQLPHNSIRDLVKHHKINPITMVGGELLLYPCGQICDPPDFWELFSNRRTESTSLLSSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMU1</accession>
    <name>A0ABY7DMU1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LRC59-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_023037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ98664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="198" mass="22601" checksum="AA754A9D7D62104A" modified="2025-10-08" version="1" fragment="single">MPKDNLKDKLEGNEIDLSLNNLTAVPVKELAEIPKATHLDLSCNLLADLPDTFCSLTYLVKIDLSKNLLTSLPDDFGNLTRLQYLDLLGNKLTVLPVSVYQLTKLKWLDLKDNPLAPEFKAIAGDCLDEKQCKKCAKDIVDHMRIEHNRIEKKLQIQRDDEKSYVVEKWNEFSALVEWQYKSFLGKGEEEPARRQTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNC9</accession>
    <name>A0ABY7DNC9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_023565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF33">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="C1q" evidence="4">
        <location>
            <begin position="685"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="362"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="637"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ99192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="809" mass="91276" checksum="02C1370FC886BA89" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNF4</accession>
    <name>A0ABY7DNF4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TFPT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_022447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056513">
        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033555">
        <property type="entry name" value="TFPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35084">
        <property type="entry name" value="TCF3 FUSION PARTNER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35084:SF1">
        <property type="entry name" value="TCF3 FUSION PARTNER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit F" evidence="4">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ98074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="210" mass="24236" checksum="4B42E2A82193C79B" modified="2025-10-08" version="1">MAEEENFGENVFMKKYLALRNKCEHIQQGNERLVNRLQHVKKLVRTYNRQRKFLQRRLDGYKDNYWDAQVPVMWEEKKTPISQAELTKRLTLKWNSLAAEDKKVLMHLFDDVAMSQVAEHYETRFNGNVRDIADSLIVAEDELKDTGDSFYELTKGRLLNVLYDLQGAGVDTTNIESIDCATTVVQVEEMMSALQNGIKCLDCCESSGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DP06</accession>
    <name>A0ABY7DP06_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">A2MG-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_023800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="4">
        <location>
            <begin position="35"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ99427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="383" mass="42950" checksum="B5088E321E7D89F1" modified="2025-10-08" version="1" fragment="single">MHWDRGSQRSYAACQGSHCEYDAQAFPVRTKFPETWIWSNLTTSSSGVATLTMEVPDTITDWVATGFALNRDSGIGVASQPANVTTYLPFFVSLHLPFSIVSQEMAVIQAVVFNYYPHDLYANVKLKTSKDAFTSMEVNKYGEEEEVKEDIEKCILVRSNDASSAYFVIKPQTIGTINLEVEATSNMGRDTVRRSIVVKPPGIEKEENVAALISLKSGAKFEKEIPIMYPPRIVPGSERVQVTVIGDLFGPSLEHLDRLLQIPHGCGEQNMVRFAPAIAAAVYLNATGRYDQKVEKRIQHIMETGYQRQLTYQHPSGGFRAFNHREEMGSLWLTAFVLRSFAQANEFTYIDPAVVERGVRFILNNQRKEGSFNSTGFVHNKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPW3</accession>
    <name>A0ABY7DPW3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_023324</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="98"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="253"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ98951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="406" mass="47226" checksum="74BF24C239D1FEB5" modified="2025-10-08" version="1" fragment="single">MIDDFWRMVWQENAEKIVMLTNLIEMATVKCLQYWPEMDQTCSFGGIDISVTGVEELRDFEIRTLIAKKAQSKSRRIQQYHFKAWPDKYVPDNGWCLVEFLNAVETQSTNAPIIVHCSAGVGRTGTFIALDNLVDQARTEKCVRPLQMVEALRRQRVNMVQTKDQYVYLHEALAEALLMGTDHVWHRQFEEVHSFMMSTEPEEKQPRMVKQFQLIEQSLTNEAQHVQDGPEYGNMETILSEIDAYLPKLKKRNSNFTQQLGAILLPSFSGNNTFLLCKSPSEEQLEEFWSLVEEQHVITVIMLTSTFSRARQTCVYMGGNGDGKVGRYSVNFIHERKNKTFNERSFSFRDDNNEDEDYLTTVKQFQFTAWTENETLPPMHNMLECLDAVRKWQPHLAENRPVLIHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSJ3</accession>
    <name>A0ABY7DSJ3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WDR19-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_022298</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057855">
        <property type="entry name" value="Beta-prop_WDR19_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040379">
        <property type="entry name" value="WDR19/dyf-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039468">
        <property type="entry name" value="WDR19_WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056170">
        <property type="entry name" value="Znf_IFT121-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920">
        <property type="entry name" value="OSMOTIC AVOIDANCE ABNORMAL PROTEIN 1/WD REPEAT MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920:SF0">
        <property type="entry name" value="WD REPEAT DOMAIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23389">
        <property type="entry name" value="Beta-prop_WDR19_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15911">
        <property type="entry name" value="Beta-prop_WDR19_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23145">
        <property type="entry name" value="Zf_2nd_IFT121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23146">
        <property type="entry name" value="Zf_IFT144_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR19 first beta-propeller" evidence="11">
        <location>
            <begin position="6"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="WDR19 WD40 repeat" evidence="9">
        <location>
            <begin position="325"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121-like zinc finger" evidence="10">
        <location>
            <begin position="1095"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAQ97925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1163" mass="131649" checksum="7F4A0800C9A2AF34" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSQ2</accession>
    <name>A0ABY7DSQ2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">INF2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345:SF8">
        <property type="entry name" value="FORMIN 3, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345">
        <property type="entry name" value="INVERTED FORMIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="206" mass="23787" checksum="3E610F578AD18F63" modified="2025-10-08" version="1" fragment="single">MKPILDYTGEKEMLGGAEQFYLELHNLDGYKQRIDAMVLRLDFGAFLDKVKPLIKTYIKTCDALMENDSLKVFLRFVLHTGNFINAISSLIKLADTRANKPRVTLLHYLVNEAEKEHSNAIAFVDELFPDLSYINRFISRYLSSNKTFMYCNVKKELAEIKESLAEITQLSKNLAGHFCESESSFKLEEFISIMTVFCEKVRQCQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTB9</accession>
    <name>A0ABY7DTB9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SPA5L-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF194">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="249"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="509"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="778" mass="84889" checksum="786B490A3E0DEF36" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTU6</accession>
    <name>A0ABY7DTU6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="80" mass="8997" checksum="3A007A82C08BADD9" modified="2025-10-08" version="1" fragment="single">RASSPPPDKARINKSEAKFMFILMDRQGMLLSHVVPNGYSKRTDTCDCKKGRTRLELSLLDLEAVEYPPFSPDLAPVEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DW77</accession>
    <name>A0ABY7DW77_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TRI33-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_008515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="107"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR01957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="196" mass="22573" checksum="30E68E4F10555648" modified="2025-10-08" version="1" fragment="single">CSKCKENDFNAEAQHFCLECEHYLCDKCVKLHNGYHKKHNVYGRGDTEKWVVSSIDRCHQHGKELEVHCDDHQELCCSVCVALNHRLCNSISHLPDLAKGFHKKAEFKQLSATIHKMRSRLDELKNAGTKYQAELKDSYKTIVAEIKALRKEIDSILNQLEKATIEQVESMIGDLETDVKDDVEKCMKINDQLKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWP9</accession>
    <name>A0ABY7DWP9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21097" checksum="D45B2E27B5791514" modified="2025-10-08" version="1">MRPTRFLRNMCIFVKKMGKHKMRLKRIAIIGVTILGVTAMVFYLTIGELPASMLIRNVNTWQVKDTGLTEVKLKRGGSPLQHYDASAAPPTSLIEGDPMPIPGKPKLLLIVAYLRSGSTFTASLFSQQPDSFYVFEPLHMVVKTVKKHMALRYVNGTAFPNGYSRQSPVSFPRVYGPLASLCISSSRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYG4</accession>
    <name>A0ABY7DYG4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SBNO1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_008263</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SBNO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057332">
        <property type="entry name" value="SBNO_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026937">
        <property type="entry name" value="SBNO_Helicase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026741">
        <property type="entry name" value="SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039187">
        <property type="entry name" value="SNO_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706:SF30">
        <property type="entry name" value="PROTEIN STRAWBERRY NOTCH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706">
        <property type="entry name" value="STRAWBERRY NOTCH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13872">
        <property type="entry name" value="AAA_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13871">
        <property type="entry name" value="Helicase_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25373">
        <property type="entry name" value="SBNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Strawberry notch AAA" evidence="4">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Strawberry notch helicase C" evidence="3">
        <location>
            <begin position="508"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="SBNO alpha/beta" evidence="5">
        <location>
            <begin position="790"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR01705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="955" mass="107244" checksum="89BC391A0686B580" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYJ3</accession>
    <name>A0ABY7DYJ3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PEPM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_008537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate lyase/PEP mutase superfamily. PEP mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF7">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE PHOSPHOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045071957" evidence="2">
        <location>
            <begin position="19"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR01979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="223" mass="24693" checksum="0C0707C5377525C3" modified="2025-10-08" version="1">MNFIITKLGIWGSGLSLSAQWCVRDSNEASWTQVVDMLEFMSDATSIPILLDADTGYGNFNNARRLVRKLEDRGIAGACMEDKLFPKTNSLHEGRAQPLADMEEFALKIKACKDAQRDPDFCIVARVEAFIAGWGLDEALKRATAYREAGPSDNRAHQVLHDTYSAFPGHGRFHGDMGEPQHAGVDQGHAGNIASVKEVFRLQDEPELVSAEDKYLPTKPQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYP7</accession>
    <name>A0ABY7DYP7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TM101-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029371">
        <property type="entry name" value="TMEM101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31034">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31034:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15111">
        <property type="entry name" value="TMEM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="326" mass="37402" checksum="3E8F7D6739987844" modified="2025-10-08" version="1">MPPGETEVVKISGPNFREFDIVKETPAEMPATIQRPDVKFRLKFSDLWENPELVLTNMAPSWLLKAGSAIPEFLLGKFPYIQAVTLLMLLAERALKMEKYPPMHPYIIYAVSGLCLLSGVMFTAKIKVKHASLIYCLVLAYLAVNAYTNKQFNYSRHVRNRLSSRHLGCLGLYILYAFMKSGRESKLMQRVGELCLATYLCAQAYLLNESYEDKKAIDELVPGGIYARYVFTLLFACAGLCFIAGYFLKDISLTVAFVVSIYIILVDMKFWFWQYRGTSYWNQVRLLIDNVNIVAGFFLLMNHYENLTEKDQDEGDANEEDREKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZN3</accession>
    <name>A0ABY7DZN3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WDR33-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822">
        <property type="entry name" value="CARBOHYDRATE BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822:SF2">
        <property type="entry name" value="F-BOX AND WD-40 DOMAIN PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="246" mass="28185" checksum="342F9CB6FBD30297" modified="2025-10-08" version="1">MILYFQIFEMEPLTCHCLHSLQDEETIKAKLPVTQIRFKHFEAADKPEHKRIVIASYASGMIKFWHYTSGKCLHTINDPDHSQMLTLAVNPENTLLCTTGDDPRVHLYDLETQKKVSTLEPSDGRDIMDGHKCRVFALMYHPTIPHVFISGGWDDTVQYWDDRMKHSQKHISGPHICGDALDIDPRHNHILTGSWCTGVTLQTTGQLLDLQQSVYCLDNDHKGHHPKVAIGSQNFIYVVREEKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1P8</accession>
    <name>A0ABY7E1P8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_009300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR02742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="316" mass="35485" checksum="B30D309835BCF89A" modified="2025-10-08" version="1">MEIFIGEIKVEELSTASELLPFLMRSQTVPAKEGMGKILSETCLETALNHHQCETYNGTEIWEWPGEWSPRIENRFWSIRLANYTVTCFVEGEYKMVLPRERRAFFAWFCTSCDESDCHSAPMKVKRLCDKAPTSKIARAAHAPALICGVLSSNPSTYVTIALSRPSFFFWIRLRVGLTINETTLVKPDHLLMHCSTSVSMVTKSMAMTLRQGEEGRESRRVRMALITISGLPDLSHVHCPLTSGMVNEELLGNDGGILLFQGREKAVRVDVQVGEVVEERLVHFFIACRRRYRARANTGAQLGVLAESLGEALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3Z6</accession>
    <name>A0ABY7E3Z6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UBC12-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_008429</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="29"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR01871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="142" mass="16195" checksum="77F99C336B672B42" modified="2025-10-08" version="1">MIKLFSLKQQKKDGVDTSQQSGSNKKSSAAQLRIQKDINELNLPKTCQVDFPDPDDLLTFKLVICPDEGFYRGGRFVFNFKVGQGYPHDAPKVKCETMVYHPNIDLEGNVCLNILREDWKPVLTVNSIVYGLQYLFLILILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E440</accession>
    <name>A0ABY7E440_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_009829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR03271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="21164" checksum="CEC5DB09E43B91D2" modified="2025-10-08" version="1">MDFNKKNKKSVSTSVLLRKQVEEQSDFCDFTVRHGLWSKRYHACVVCSSSAFIQAMMRNNFNEKAKGFLELKLGCAPKLSMENVSAVIHMAEFLLIPNLKAFCMSWINKEIMVDEENVETFLHLTSFFDIEMPTLTKYIRQHLPELLMGNQLLTLTVDTIENMFLDETLSYVTADAKIDFVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4X5</accession>
    <name>A0ABY7E4X5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR04011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="850" mass="94958" checksum="7FB22098CA8CAA41" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E627</accession>
    <name>A0ABY7E627_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35151">
        <property type="entry name" value="ELONGATION FACTOR 1 BETA CENTRAL ACIDIC REGION EUKARYOTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35151:SF2">
        <property type="entry name" value="ELONGATION FACTOR 1 BETA CENTRAL ACIDIC REGION EUKARYOTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR03874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="376" mass="44518" checksum="3486B2BFC9BA711B" modified="2025-10-08" version="1">MSALRYFDVRSYDCLTIRSCDCRTIRSYDCLTIRSYDCFTIRSYDCLTIRSYDCLTMRSYDCRSYECLTMSSNDCLTIRSCDCLTIRSYDCLTMRSYDCRSYECLTMSSNDCLTIRSCDCLTIRSYDCLTIRSYDCLTIRSYDCLTIRSYDCLTIRSYDWLTIRSYDCLTMTSCDCLTIRSYDWLTISSWDCLTIRSYGCLTIRSYDCLTIRSYDCLTIRSYDWLTIRSYDCLTMRSCDCLTIRSYDWLTISSWDYLTIRSYGCLTIRSHDCLTIRSYDCLTIRSYDWLTIRSYDCLTMRSCDCLTIRSYDWLTISSWDCLTIRSYDCLTMRSHDCLTIRSYDCLTIRLLYQECLPRDILHLGRVNSLQSQDSSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E904</accession>
    <name>A0ABY7E904_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CNTN4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_020839</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="90"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="192"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="581"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR05470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="604" mass="67079" checksum="576B03AC2C17B8AE" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9G4</accession>
    <name>A0ABY7E9G4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNF34-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_010349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd16500">
        <property type="entry name" value="RING-HC_CARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051728">
        <property type="entry name" value="RING-FYVE_E3_ubiquitin-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055111">
        <property type="entry name" value="RNF34_RFFL_HeH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057299">
        <property type="entry name" value="RNF34_RFFL_SAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879">
        <property type="entry name" value="CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879:SF15">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RIFIFYLIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22968">
        <property type="entry name" value="RNF34L-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23632">
        <property type="entry name" value="SAP_RNF34_RFFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="296"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR03791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="343" mass="38168" checksum="8B159D4B7E8B7C3E" modified="2025-10-08" version="1">MGKAQSKSSRGRKPLYRKDKDCLNIPKEGQMGAGVVKLEQDGTQTRFHINPGRANQHMATSSAGGQCQGCDAVLPQIVKKMVCKDCGRTFCNNCSLQHGHEHQCKKCNILLCGHFTRSQLLQWKVKDLKCLLTKQSVNTSKCKEKSDLIDLIFSYFGNTSDGYQSDENNTSRNTVPDVDGGTLPRSTSFPETSSSEVGDGTSVDTETPRPTHQPEPASAVNTPTTQLDQIQSEEEIDSLNNRALKRLLVNNFVDFKGCRERSELLQRVKRLWNENQVNKKKADGERGGVDNEYEICKICMDAAIDCVLLECGHMVSCTKCGKQLSECPICRQFVVRAVHTFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9U3</accession>
    <name>A0ABY7E9U3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_021308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF133">
        <property type="entry name" value="SI:CH211-262I1.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="342"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR05939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="677" mass="76954" checksum="693FA52D4D50D1F9" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAD4</accession>
    <name>A0ABY7EAD4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_016953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cornifelin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR06995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="159" mass="17206" checksum="DF010BE53BCFB0D0" modified="2025-10-08" version="1">MLHHCESESGDELPAVDITPRTPVVAQPRSARGSRVAIEAFTPRKRTDKTLWQASLGHRDWSSGLLSCKEESCFSIYHVVCCPCLVVGSMLGRLGEPRGAAALPCVWPLLRTKIRTLGGVRGMVLGDCCASACCPCCSLLQMSRELGHMIVQPAQFLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EB65</accession>
    <name>A0ABY7EB65_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">R213A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_017236</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF16">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="3435"/>
            <end position="3477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="453"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR07278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="4217" mass="483883" checksum="E4C08390BE0B91E1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBQ8</accession>
    <name>A0ABY7EBQ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HMCN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_021223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047469986" evidence="6">
        <location>
            <begin position="21"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="20"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="129"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="243"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="416"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR05854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="520" mass="56894" checksum="48B0C192E6198BFC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDB1</accession>
    <name>A0ABY7EDB1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FZ10A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_016890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF99">
        <property type="entry name" value="FRIZZLED-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046251019" evidence="4">
        <location>
            <begin position="20"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="5">
        <location>
            <begin position="26"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="31"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="39"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR06932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="189" mass="21696" checksum="ED3AC34366B6F8EB" modified="2025-10-08" version="1">MKWITLFCVTSILFGHGNSFTPQDHYHYNRCEKIDIPMCNNLRYNMTRMPNLVGNQNQKDAAMQVHEFLPLVQVGCSKFLKFFLCSLYAPMCTDMQQTGDERETMVVPACRSMCLEVRSKCEPVLNKLNFQWPKSLDCGPLPEKSDPKEGVLCMEAPSDAEDTEDLGTIGGHGKKYNEELIRYFNIHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EE89</accession>
    <name>A0ABY7EE89_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13046" checksum="56483A39E51D365D" modified="2025-10-08" version="1" fragment="single">MTLRTLQVKDDKRNTLSAKIGNLDLLIVKSLGLVAIYFCKYIIAEIKSSTKLFGEVFIIVLGDLYQLQPVRQQFVFMPVSDHLARLHGSLLNCFGTHVYKANQNYEKEGGPQLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFD9</accession>
    <name>A0ABY7EFD9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="385" mass="43877" checksum="1F9A49B2CC8637D3" modified="2025-10-08" version="1" fragment="single">MTAILYQWGNGLMDSASALESPGNAWNKASLQEYYLQKAYHYPSNRRKINKQLKQQIIKFHPIEVKETDVICNKCRLKYFYKQKPETNSKSENEINENSSDEEFHPPLPNKAAFASPPSVRLNIPSTPKSHSRCFICKRPGPKLIVVPSEARFTAFVQRNVIIKSGTRCCPVHMNDSSIKDEALKSVKAAESAYVNRDTVLELLNKLRESCKKSNRCFDFTTLNNEEYVDLTGLSKAAFEDICYCIEGHIRNTPVRDVHTTVGSWNTIQDAFITTKRSDGCMVESANARLKRWKYLESESNQTVCNKYLPPLSSSTDDDERQAQQMLQLVIHGNSLQAEIEEGNLEKSRAVWIPIDDTELESFLRLTEDILRTLTCGVYQLKLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EG20</accession>
    <name>A0ABY7EG20_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="232" mass="26278" checksum="18CBE1C3A5D5B53D" modified="2025-10-08" version="1" fragment="single">YTWTLGGYSVLEYQAKYDSVLRTQLDNSDPRIKNTSPEIQNEMITLSRDRIRRPPFFGLFEDETKEMSSEKKMALCLRHFDRTTKSNLRQADNLNLNSAAAKAGTSRAAIIQFGFIIGLVVVELCRAGADISDFKKQNCNQTLGNKQLLCITLIMDGGILQKISQELCPTVTDIPCNQEDSSDVPKRDNSRAPQNDLLAIKKGQQEQIALMQEMMQNFAHLKSDVDRLRKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EH59</accession>
    <name>A0ABY7EH59_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">T2EA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_017687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR07729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="257" mass="28415" checksum="49995BB4F013309A" modified="2025-10-08" version="1">MLLGREIRCTICQNEVIEDESAVNAKDARTLLAKFNEQIQQLYDLLRECEDVKLAPELMEPEPIDIKASSRSRSNKPAQDGDKWSGDATRYKTAFNYTEGSINVTMNEEQRQVKEATKEQPIWMTQSTVDGVPLDTANEVAPDVSGSAKKESGAKTEVNREIENLLMIHEKKSGGVNLPAIPLAGDTAEDSNSSDSDAEPSRPQINHQAEGLCADLSSMMLRCGLVYKIVDSVHPFLLAEGEFEASDLQRDLLANWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHV7</accession>
    <name>A0ABY7EHV7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SYT12-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_018430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF252">
        <property type="entry name" value="SYNAPTOTAGMIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="258"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR08472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="395" mass="44110" checksum="29567DC235C0B894" modified="2025-10-08" version="1">MSDVGIAMLVVALIVVAVVLLAVLIRIFGVYRITSCFATSEEKAVLTKNEQYNGYMVGSESSEITADRGAGKYVEYDTLQTDPRYVDLESHSPPREESARSSPVSIGTGSMASDAEFGHGIKRAESCDSVASDSSVLEMQPDMPKFGQLEFALEYDREVSELVVSVIQARDLTANQYTGTLDTYIRGMIQPAEAEFKLQTKIQRNTTDPVYKERFLFNIPSETLEERILQFQLFAIDKYQRHKVIGESDLRIGDKPTEFGDIMFSLSYLPTAERLTIVIVKARNLKWNAGKDTGDPFVKVYLLQNGKKVNKKKTTVKRGEQNPIFNEAMIFSVPSSALPTVQLRITVAELLPDNKTPSLGHVIVGASTSGTEVSHWNQMMTSLRKPVAMWHYLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIA1</accession>
    <name>A0ABY7EIA1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="190" mass="22257" checksum="7CDB2E81450ACD37" modified="2025-10-08" version="1">MTGFQKKSEKQKDVGILIINTLTDVCWFLDPFIERFEKRCINIPKVWKFHGFRDWRSQHKKPLQISSEELAKKSNALAKVFMLPWWLNRSFSAFKDSVSELLSAMEYYHKSLADQLERTQRNHYSSTPVRSVADNWGLTVIEVDDLRSKILERLPLNTPAPSASWIRLNFMPSNQFSASALNYTRRFNVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIR3</accession>
    <name>A0ABY7EIR3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P52K-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="540"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="649" mass="73104" checksum="693C63455142B517" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EK28</accession>
    <name>A0ABY7EK28_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="151" mass="16920" checksum="18615D57013F65FD" modified="2025-10-08" version="1" fragment="single">GISTRTYEDKCASHIHIFQPLQEVTCRNVLIKLISASLSLRRTVNVAPKIQITSVCQWMAAITPAALFFFIQTPTGQAASYVFSVAIENHISHTQVVALVVQKKLCWTGSYLSNRNFEVEYQDGHAGCIATLQYMEPPSERKIDYVIAEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELE8</accession>
    <name>A0ABY7ELE8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="106" mass="12157" checksum="0B53E4838B865E86" modified="2025-10-08" version="1">MFYTKSTRMHVQQMCKVQVEHPDGYQRFEEENHVVRRSDRLWSGLSVNLIIEPVLMRSMKTSGGLTRGRGMTQQQPVLWLLAMPPCAEVNNAMQELTGVNYNTGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMF3</accession>
    <name>A0ABY7EMF3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA primase small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_036086</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0639">Primosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR11010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="224" mass="25850" checksum="2FE817C3B2474C56" modified="2025-10-08" version="1">MAKLRRSAKRLPQSTRVLLHSKGRHLHPPREHKTVKAAAFQAQEKELVFDIDMTDYDDVRSCCSGADICDRCWPLMQIAVKIIDRALRDDFGFEHLLWVYSGRRGVHCWVCDETARKLSQTGRTAIAEYLSVVKVEGKRSPNLQDEVMLQYCYPRLDVNVSKGVNHLLKSPFCRVCVPIDPENIDNYNMTSLKPCIDVFNRFLSGLEKSWQGKMIEQSDIKMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EP18</accession>
    <name>A0ABY7EP18_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="96" mass="11556" checksum="CD4D345FBD789274" modified="2025-10-08" version="1">MESLHAAMRLITPGCFWSRYLKDAYYTVNVSEEFRNYLRFIWRALLKMISYNIAIPYEILYTKYLEQDKTSALKYNKGNFDSQMNLSAEFLNDLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQV4</accession>
    <name>A0ABY7EQV4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">IRF8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_026513</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00103">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019817">
        <property type="entry name" value="Interferon_reg_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001346">
        <property type="entry name" value="Interferon_reg_fact_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019471">
        <property type="entry name" value="Interferon_reg_factor-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949:SF53">
        <property type="entry name" value="IRF TRYPTOPHAN PENTAD REPEAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00605">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10401">
        <property type="entry name" value="IRF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00267">
        <property type="entry name" value="INTFRNREGFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00348">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01243">
        <property type="entry name" value="IRF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00601">
        <property type="entry name" value="IRF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51507">
        <property type="entry name" value="IRF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="IRF tryptophan pentad repeat" evidence="6">
        <location>
            <begin position="81"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR12333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="495" mass="56691" checksum="9DCB0C8074B48A07" modified="2025-10-08" version="1">MNRVTNIGKNQKQGSFKSMVLRRSGIKTSPLVSDTIVETDGERTICRTLSTESIKTHCSNSGYDGVIPDMSNGFPVAEQTRQRMKPWLEYHINSGNIPGLHWLDKDKKIFKVPWKHVGNREWSESDGAIFKEWAVHTGRFREGVDTPDWPTWKTRFRCALTKLPDIKELKEFNRLDGQTDEPYRVYQRHYSSCYSVCACTHGMSVRSDRGDGRLTSDLERISESDLLKISGDMNIQQISIDQNMDITDEQERSEEVERQAVSRPSTINPINFDLDESDSKLYVMVNYLMRRVYEGLCSNPAGCRIFHDTQVPIADVNEYREMFGPEDAAPIRLPALDQQLNMQQQRLTDDLLLAADRGLVLHMRAGSIYAIRKCRCRIYISSPSYNNGDTMKLDRDVETNIFDLQNYFKPALQRFLHQRGPKPSAEVIISFGQKFEPSKDSMNDLLISAAVIHAEAFHLLTRIMCSSSLTPTEEFSNSDQIDRAMGLRYDLSQPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQV6</accession>
    <name>A0ABY7EQV6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_025672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="100"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR11492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="207" mass="23574" checksum="B1C235BAE8E74DBC" modified="2025-10-08" version="1">MAANNHRPNVLDIYNGRQLLERYRLDREGIEFLEAEMNQVIGPVATRNRSMTVTEKILITLRYLATGGIQLNDEDIHYVSQPSVSRAVCQVIDALANPHAHKTTRSRVERGIGQLKRRWAILNGEIRLHPEKACKVIIACAVLHNICKRRNIPLLDILPNAAGQVMNQGVYAGPQEGLRYREFVAQSFFLNVVEMQYRLVPSPYLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ES16</accession>
    <name>A0ABY7ES16_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">KCNH8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_035062</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003950">
        <property type="entry name" value="K_chnl_volt-dep_ELK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF637">
        <property type="entry name" value="EAG-LIKE K[+] CHANNEL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01465">
        <property type="entry name" value="ELKCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="14">
        <location>
            <begin position="442"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="567"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR09986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="667" mass="74809" checksum="4879E5CAB5E05D2F" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESD0</accession>
    <name>A0ABY7ESD0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_026209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF229">
        <property type="entry name" value="TRANSCRIPTION INTERMEDIARY FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR12029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="274" mass="31100" checksum="D1F622B4C4D99D22" modified="2025-10-08" version="1" fragment="single">MASKHTQSFKDSMSMASDLIHDFVCSPCQEDKLNTEAKYFCGDCSKYFCDKCLKFHSKLFKEHVVLGRKDVDKWVGQGDALISCDFHPGKIIELLCEDHAEMCCHLCVSLNHRMCRTISLISDLAKDVYKMADFKQLPSKVAKLTTSLNQVRVVRKKNQGSLKTSGKSMLTKIKDLRKSLNQLLDKLEKRTVKQMDSVLADLDDTLQKDIDSCTLIHDQLNALMDTIQSQGKDDEPRSYIGFRKSEEKMAEANSLLQVMSTKPELSATFQPDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ET27</accession>
    <name>A0ABY7ET27_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_026252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055353">
        <property type="entry name" value="DUF7619"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052108">
        <property type="entry name" value="MEGF/SIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035">
        <property type="entry name" value="MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035:SF109">
        <property type="entry name" value="PROTEIN DRAPER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24595">
        <property type="entry name" value="DUF7619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR12072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="522" mass="56575" checksum="1A10F968E0B000EE" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ET47</accession>
    <name>A0ABY7ET47_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_025918</name>
        <name evidence="10" type="ORF">MAR_026023</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.</text>
    </comment>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="78"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR11738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR11843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="202" mass="23809" checksum="152BA1D91BEAAE26" modified="2025-10-08" version="1" fragment="single">MALEALDDYYNIDDILATNEKIPCKIEMPIYRLGFLDSSSINEDLMPGTKIEFPHWMARSLCSRKRHMVSVETPKQYRESYREILTADASVVDLHKLGPYYFSFGTHLLKFDLPESQDVAKMLVKSFQHRFRKVMDSSQNSYNEDTSKLTEKLDESERLLFRAGQLGLNDFMRWETRQTEKLVTSEMVKKHRKRKRAIMEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETU2</accession>
    <name>A0ABY7ETU2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="742" mass="82017" checksum="2BCD812E3BA0E401" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUY2</accession>
    <name>A0ABY7EUY2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CP4B1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_003848</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF201">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 4, SUBFAMILY B, POLYPEPTIDE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR13743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="150" mass="17071" checksum="E431B417ADF401FA" modified="2025-10-08" version="1">MESGRDASIVGRVQINLIDKNVTTVFSQDLARLDYLSTCIKEALRLYCPVFFIQRQMTEAINIEGFTIPEGSHVAIDIYNIHHNASMWGEDYDNFRPSRFEGDAARDMDPFAFVPFSAGPRNCIGQNFAMNEMKVVISRLLHRFCLRGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVK4</accession>
    <name>A0ABY7EVK4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CAB32-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051001">
        <property type="entry name" value="Calbindin_Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19972">
        <property type="entry name" value="CALBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19972:SF10">
        <property type="entry name" value="CALBINDIN-32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="92" mass="10617" checksum="3B4B1E15D16EB23A" modified="2025-10-08" version="1" fragment="single">GCSRLNSDDIDRVFNLYDVDHNGYIENDELHGFLKDLMELVEDDYDADDLLDCQKILLDKCDMNRDGKINKEELTMVLTSCNKNSTVEEPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWM1</accession>
    <name>A0ABY7EWM1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038832">
        <property type="entry name" value="CDCA3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34756">
        <property type="entry name" value="CELL DIVISION CYCLE-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34756:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="224" mass="25152" checksum="D3B5E80FBAAE5E49" modified="2025-10-08" version="1">MGTTNSHEEVPTISDSPPPPSKPDQMNRILSFDPRSPTSEIPRTPIVVEKTPEGALQDPLDPRSPTVGIDRTPLNALQQTKLDSAPNHHHHSDKEEGQMLPDDIHMLGVTGIEDLSLEDFPTSESTRLVPHDEQVMLELKNTKLKKKKQKNSQPKELFPAKTTAALKDVTRSPLSARTIDVNSPANIMQRKQIKDIDKKMTCAQENARSKFIVREKENILRHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZF6</accession>
    <name>A0ABY7EZF6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PAR12-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_004326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF2">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WWE" evidence="5">
        <location>
            <begin position="344"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR14221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="455" mass="52200" checksum="CA7971253F63D624" modified="2025-10-08" version="1">MMKPENHAHFCTYANDGNYSGRDGSIPEPMFERNAATEICESYNKNGGCRKDKAGKPCPYLHLCKNYIIRECKRKNCQRSHFIHESMVRNVLEKHDISMGRIPKENLAVFRKIMQANDGNYSGRDGPIPEPMFERGRPPQGKLIRPMSGMTIQDSGVEPTSRRPPLFPAQGGAEAVIPGKRTTRSAYSTTSARTMRSQSPVVPFNSRRASPSPVGRVRQATSDMVSETAAINILNKKICIYHLKGRCAYFKRCFNYHCELLYQWFYRFDDSDNWKTVEPQENMRMELHYSDPANVEYIQDHESRGWRQAPDIPSVVNRDVRNFGFAPPCNKLAVDADGYRSTISSQDLEQAYISNPDGQLKLSTQGHEYILDFAKMVQRNLFYTTEREVSRRPKFVSKDELERRKKQPIIQRPAGAATSGFVPDAPPHWNLRPTDELLNHCKLVPVRISFYIKMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2X2</accession>
    <name>A0ABY7F2X2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="174" mass="18106" checksum="136FE318BEE7E092" modified="2025-10-08" version="1">MKTTAVILAVMVFAAVLIQDIDVHFIAIKDTSNSYSNPGADVAVANGATRNSSIPWADVANGAVLCAVGAGGVDMEADTEADTEADMVAAMEAAWAGEDTEVDMGDMGADTEVDMEVVGVDTDGERGAVMEVTVEVTVMVAVMVVMAVAMDGARNIEPSRHKWFVNETQASCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3H2</accession>
    <name>A0ABY7F3H2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_031317</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045268569" description="protein-tyrosine-phosphatase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="438"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR16723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="636" mass="72128" checksum="DBF0FE9B509CD171" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3Y1</accession>
    <name>A0ABY7F3Y1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_031059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR16465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="147" mass="15992" checksum="2F65F3D91795432C" modified="2025-10-08" version="1" fragment="single">NNCNNACANNSCDALNGQCDQGCEYGYSGSFCNSSCPANCKSCHQFNGRGCIEEIVADNNGAVMIGAIGGVIALLSVFLALSVGYIVFMKRRHNREHTEKQSASDSKADEEARTYEQLQERTEQPNFQNVKDNGSDNYAVLFADTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F515</accession>
    <name>A0ABY7F515_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RL11-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_031063</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="6">
        <location>
            <begin position="69"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR16469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="167" mass="19518" checksum="E77A804D3996E495" modified="2025-10-08" version="1">MADDKSKDKEKNPMRELRIVKLCLNICVGESGDRLTRAAKVLEQLTGQQPVFSKARYTVRSFGIRRNEKIAVHCTVRGAKAEEILERGLKVREYELRKNNFSVSGNFGFGIQEHIDLGIKYDPRFNIAQRRRKKNRVGLKHKVTKEQSMKWFQQKVSSRITYQEYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5M7</accession>
    <name>A0ABY7F5M7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SO1C1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_030941</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF76">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="9">
        <location>
            <begin position="336"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR16347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="505" mass="55956" checksum="6E3C9A545304DD4D" modified="2025-10-08" version="1" fragment="single">VSMLEKQFGFSSAETGFLMSCNDIGYLLCVVFAGYIARKVHIPRGLGTSTIFFGVCGLMCALPYFISDRSTYALSDRQPMPDSNISVKSVVSSSSKVPLCLNSSGVGHYDARCDAQSSTAERTAGLQELYIKKVAFTLIAVGMFFQGVGKSCRMPFVSIYIDDAVEKRKTAVDITPRDPRWIGAWWLGFLVFGGFSLLFSIPIMCFPRYLKSHKRRGDLHTIAKEKALQKLEKNSTREAIVKEVKEFLAAVLRLLKNPTYLVLTLSTVVNLMGVAGVLSFMPKYLASQYTLSSIAAISLGSFLGGIITRRIPMTPLTTIKMLLIFYAVNILCSACGFFLGCKQPVLFGDNAQIGCECNDQKYFPICGQDGRSYFSPCHAGCSVKDKRWMPGPVVFGAIIDGTCTLWKYTCGERQSCLLYDIVFFRNAVHGYRIIASALAMIILSSLIFYFRYKGHDDWGDGMRREIEKREVKLNVQGAKPNGNGNENIIAQKKDVEKDTLSEDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F606</accession>
    <name>A0ABY7F606_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027897">
        <property type="entry name" value="DUF4559"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15112">
        <property type="entry name" value="DUF4559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR17305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="284" mass="32243" checksum="8C80CC9FB97DDAA7" modified="2025-10-08" version="1">MEHYKKRLNTPGNRRWLKGSVAVNIAERGLSEFTSYKADRLMNSICNAIRNTIRRKLCQASSSISKCTICSTANIVQCDSGNGICKPGRNKPCKLHYSAITNQRVAYRQCPNHRCDIIREYLKRLHRFGNPSWQNVNAQKWCLNAWQIAKAFFPKDGYIDKETVDETDFNGIISFVINCRDFQQNFSANLSQPSNICTEARDAGKELRHANGLEVSEADLKTWFTALKALFSDPTFKGANAHAQYALDQLNMKHVLARLRHSDGFGNKLSYAYCTFVSSRSHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F6D4</accession>
    <name>A0ABY7F6D4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="135" mass="14929" checksum="D7E813935625456A" modified="2025-10-08" version="1" fragment="single">SKEPDVSHLATRNDSSCNLYDAPSVTFATDTAGDERYTVVVGTKSDVLDQDNREISIDEAIEFAREINNDIDISKLDGDPYFETSAKTGYNVAKVFDYMFQYCLPEAQKSDKLSDGSTINLSEGAQTRSRPANKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F830</accession>
    <name>A0ABY7F830_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="108" mass="13123" checksum="097109952004DDD9" modified="2025-10-08" version="1">MLHMDSATSRIGRKVGYEPEKGLQFMVKFAVFFILLNTFLKFTLFQRHRREDTNHDYWRGTVNARRKRMRFLVASAMIGMTLSIMFVFRYVTNYPSYKNRKYYQEQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FC79</accession>
    <name>A0ABY7FC79_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NUD14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="66" mass="7370" checksum="BDFEBF360B9E99F1" modified="2025-10-08" version="1">MKVSSGGGNANEGEMIDVVEIPAQEGRKFAMDESINKPVGVLFGVMWFYDNVYDRKVKGTKRKDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDZ0</accession>
    <name>A0ABY7FDZ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046329944" evidence="1">
        <location>
            <begin position="20"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="194" mass="21997" checksum="5962C158388626AA" modified="2025-10-08" version="1" fragment="single">MGLSDNCVLLCILIPAMQCGKYTDVTRLRGDLDAFLANNSGLQLLLGNFLTEPSPRKQVFRSNHFNKLLMLKSAVAEILKEHDAIAHKYMPYFTSQHYLKRDETSFQGSQRFVNVLKTNFGDFGNTAHFDGHQRKKYQRNFSYNTSVQKIDWQPTANHLFQKLALSVIFSFLAKHNATAPSSTTVPSLNPVSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FE16</accession>
    <name>A0ABY7FE16_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ST1C2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_000806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="60"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR18968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="297" mass="34502" checksum="627E36FE7B8F1D10" modified="2025-10-08" version="1">MSMFLQKTTMAAENYELRDQDGKTIHGLMTLNGLPLPTFSSSPEDRADHLQAVREWKLRDDDIILCTLPKCGTHWLKEITTLLLSGKSEMVVHSNPGSLIEAFPIDRLDEFPSPRVLCTHLPLEMLPKPIMQNKNKVVIVMRNPKDAVVSYYHHLRNMKIFDYDGQFKFFMEWFLEGKLKEYERFANDKSDQCIIIYYENLKTNGMGEIKRLARFLGANDTDDFCQAVFDACRIENVKEKRAQPKDVQEIMWKTGGSFYRKGIIGDWKTHLTVAQNEQFESIIAEKMKGSNIKFRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FE25</accession>
    <name>A0ABY7FE25_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DZIP3-like HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="849"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="926" mass="106146" checksum="A00B132AFD2A90F2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFQ5</accession>
    <name>A0ABY7FFQ5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_014936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF16">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="217"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR20962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="586" mass="65815" checksum="45BF35C065D085B7" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHK6</accession>
    <name>A0ABY7FHK6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_002487</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="1846"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="2159"/>
            <end position="2310"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="2499"/>
            <end position="2693"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="2809"/>
            <end position="2975"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1110"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3106"/>
            <end position="3133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR20649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="3203" mass="367690" checksum="B0C75EC7426954FE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJX0</accession>
    <name>A0ABY7FJX0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HYKK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_016477</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050249">
        <property type="entry name" value="Pseudomonas-type_ThrB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21064">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21064:SF1">
        <property type="entry name" value="HYDROXYLYSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR22503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="219" mass="25359" checksum="A6F16A38E7729DA1" modified="2025-10-08" version="1" fragment="single">GFYHAFYENYSFLWSLTEMTRLREFFPAIKDANDLDIVKKVVDAFERDIVPRYSEFTPGVIHGNLNDQNIIVSEVPGQEIVPCAQCVYDVTAILDWSDITKSYFVFDIAINITYLSIECEENKQLDVSGHILKGYAKYRKLNDAEFKSIPFLVCSRLCQSLVFGAHAYSQQPGNEYLLTTAKKGWPLLRKYWSADYSKLLNNWRVIMKSSLISNKHLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKM2</accession>
    <name>A0ABY7FKM2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">COLL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_016579</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd01175">
        <property type="entry name" value="IPT_COE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3180">
        <property type="entry name" value="Transcription factor COE1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032200">
        <property type="entry name" value="COE_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038173">
        <property type="entry name" value="COE_DBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032201">
        <property type="entry name" value="COE_HLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038006">
        <property type="entry name" value="COE_IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003523">
        <property type="entry name" value="Transcription_factor_COE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10747">
        <property type="entry name" value="TRANSCRIPTION FACTOR COE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16422">
        <property type="entry name" value="COE1_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16423">
        <property type="entry name" value="COE1_HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="IPT/TIG" evidence="12">
        <location>
            <begin position="74"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="246"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR22605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="330" mass="35844" checksum="8802489F74304C80" modified="2025-10-08" version="1">MSFSRFFLKFFMKCNQNCLKNAGNPRDMRRFQVSVTTTVAVDGPLLSVSDNMFVHNNSKHGRRARRLDPTEGATPCIKAICPSEGWTTGGTTVIIIGDNFFDGLQIVFGTMLVWSELLTSHAIKVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFVYTSLTEPTIDYGFQRLMKLIPRHPGDPERLPKEIILKRAADLAEALYSMRNPNQLSLPAPRSPPMNNPAMTGFNTYSGQLAVSVQENGQWEDGYNRGQSSSVSPRGYGSTGSTPHSNGSAYSSTMNGYHSSAGGLGNMGMSGLVGSPFSAMNPFALQPCNATQPYGSSIVSPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKR0</accession>
    <name>A0ABY7FKR0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TRFR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_015601</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF233">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="64"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR21627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="387" mass="44436" checksum="E37AC6499F398959" modified="2025-10-08" version="1">MAINSLDINLTYLAVDEKNKYELHLDNTTTGIEIENNVVPFIPLYIYICVPIVNVIIFLVGFVGNILVIMVVIKVRDMRTPTNVFLLNLSLADVLVLVVCQPAALLEFFGKDRWFLGELMCRPVGTPAGKWITLERYNALCQPFKRRVCYTIGMTIKSLVIIWVTAFCLTIPFVIITVHDEAKFYDGSDIHVCRTKINGTWKYCYIVFIFVMFFVVPFIFIIVVYYNIIRQLLSDTLKILAQNDRSAMHTIQARKQVVYMLIFIIILFFVTLFPIRVVTLWLIFSPPSSVNQIGLEGFLNLIAWARVLMYINSAGNPVIYSLTSSKFKTAFKRLFRTQNGNKQGSINNTTARYTLQNRHSDKDGKEGHVYIALKKKSSNRAMLTEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMT2</accession>
    <name>A0ABY7FMT2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_036561</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14336">
        <property type="entry name" value="UBA_AID_AMPKalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049020">
        <property type="entry name" value="PRKAA1/2_AID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21147">
        <property type="entry name" value="AMPK_alpha_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="14"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="347"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR22892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="469" mass="53006" checksum="8A03FF64A43CED7D" modified="2025-10-08" version="1">MADKNQPQVKIGHYIIGDTLGVGTFGKVKIATHHLTNHKVAVKILNRQKIKSLDVVGKIRKEIQNLKLFRHPHIIKLYQVISTPTDIFMLKEHEARRFFQQIVSGVDYCHRHMVVHRDLKPENLLLDHNLDVKLADFGLSNMMHDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFNIPEYLNKEVVSMLCHMLQVDPLKRATMKDIRDHDWFKKDLPAYLFPPQNDNDASIIDLDVIRDVCDKFGVSEYEVEAAILNGDPMDQLVIAYNLIMDNKRIIDNTSSSVSFQDFYLASSPPSDSFLLSGRHSHLLGSPQASEAMPTSTSGLKPHPERMPGIRSQSKPHDIMHEVFRAMKALGFTKMSLQLYQVDQKSFLLDFKSLLEGSEDGLNRASSMASQGSSDNEEKMEVDEPARCHHTLEFFEMCAQLITTLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQ55</accession>
    <name>A0ABY7FQ55_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_036520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR22851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="84" mass="9209" checksum="D759FC9C1C2853E6" modified="2025-10-08" version="1">MSVCSATAAASSWRRQSRSSSTRASTVEQHFYIDKGGLKPVDQRKYSMISTTRPSSSSSLCCVISVLLSCVMIGWSESRHDFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQQ6</accession>
    <name>A0ABY7FQQ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MEGF6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_036905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045701205" evidence="3">
        <location>
            <begin position="22"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="751"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="209"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="275"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="306"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="368"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="399"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="430"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="460"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="529"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="559"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="592"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="653"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="684"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR23236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1010" mass="108684" checksum="2DF8F4D0F82B18DC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FR14</accession>
    <name>A0ABY7FR14_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_037701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR24032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="427" mass="48195" checksum="CF8E222EDF44296D" modified="2025-10-08" version="1" fragment="single">MADVAVIEIEDPVCTLNDSVFPVYGMCCPIPECKCLQYFTHIASYSRHYAERHRLMIYEYKCELCCATSSHKKQIENHLGHVHKEKKPNMFIRRLRHNNKYINPCGYLPPSVACKNDNQALTKTFRRLALKEKRRDLKNFIWEKLGTDKPKLESNDSRLTAANGSKIDILGQATFKFDTEAKSYQWKFLVANLEGIAGIIGQDFISSQGRTLSWKTLVWQTKAGRVCLFKRESSHVGRIRVEKRVIVPPETEMLVKAGPDCPLYGKTGVVEPLSRIAKKGLFVAKSVLDGQSETICSVINVTDKPIRLQTGEIIGNIGSVEDVSLINAPLNAQEMSVTVPSHLQCLIDGLPDDLTVDQVDQCKRLIVDYQDVFLSPDNKLGQGVLYKKYECDGSTHLTLVAPPDIRLEIFHLLHNHRTAGHFGRDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVE8</accession>
    <name>A0ABY7FVE8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">APLP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_036825</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.80.10">
        <property type="entry name" value="Lipovitellin-phosvitin complex, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.50.20">
        <property type="entry name" value="Lipovitellin. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009454">
        <property type="entry name" value="Lipid_transpt_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015817">
        <property type="entry name" value="Vitellinogen_open_b-sht_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06448">
        <property type="entry name" value="DUF1081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01169">
        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0758">Storage protein</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045229344" evidence="10">
        <location>
            <begin position="18"/>
            <end position="4832"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="11">
        <location>
            <begin position="1"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="4669"/>
            <end position="4832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR23156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="4832" mass="533029" checksum="45C98FA95F048F16" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZP4</accession>
    <name>A0ABY7FZP4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">THD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_013389</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tumor necrosis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471:SF13">
        <property type="entry name" value="TNF FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471">
        <property type="entry name" value="TUMOR NECROSIS FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50049">
        <property type="entry name" value="THD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THD" evidence="5">
        <location>
            <begin position="113"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR27685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="266" mass="30255" checksum="4F354F02F2512FFE" modified="2025-10-08" version="1">MIAMFALPSCLTFLDRPCNIDTCVLVLCIVWTMPDIKQIHADKEICLQKNDKNIKCGETTSLLHGVFEKEIASSFAAATKQEKIQTEKYIEDALKHDVQLMTDYKNSLWDMKPSAKLVGNREGQEDVQGNNAMATVTSWRHDKDLYYTTGFQRYGVRFQNGRLIVPVSGTYYIYSFLGLTERRLTDEGVPVKSSSTNEIKHALHKYNVLETDDIEIASNLQSRKNATRGYFNYYASQIATLAKLRAGDEISVAVNYYGFTERIQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G089</accession>
    <name>A0ABY7G089_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="322" mass="35864" checksum="9177EBF58F9606B1" modified="2025-10-08" version="1">MIQAGLDETRVALALEPEAASIWCDTLDADTRAALAGTGTQYMVIDVGGGTADISIHEKKQDGTLKEIHQPSGGPWGGIYVDANYLKFLEHVFGEKAITALKTEEMTDYFDVIREFETKKRTFTKQTKGKFMFKISATTRKLSEKFTGQNLEQRIGSLGYGDSVVVKGGDKLRVDPDIVRAWFDGPINNLVDHVKSLLKEPKLRAVQTIVLVDGKFWVSNGFDVFVRVNENVPIDHQITKEYIPTGYKTRTTVYRTASENPVYVTDPGCELLGELVTEFPLDIPLSELGTDTTFMFGGTELVVKTRVRKTGEEQILKLNCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1J0</accession>
    <name>A0ABY7G1J0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_012851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR27147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046369093" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="77"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="253"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR27147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="318" mass="35188" checksum="034F3BE1B8D7405A" modified="2025-10-08" version="1">MIGYTTSLYALVAATLVIAGHDEHVQCTPGIFQIIGKADCTGFFMCVFGKKVEMPPCPPRSVFSSSANVCVPKGSMYDDCKKTTEGSGGHMPLLPDLGVFPHPTECQAFYNCSVRYTHGIPRFFEQHLVECPYPQMFNTETKQCGHFENVKCGSRTEFKDGCKLTYQTLSNQCPVAHCRPCSVDLPSCVGKPDGINVHPVKLWSPFYAVCYKERTIKEERCQADENGRTQLFHPEKNECVSLDMIPREHGGMMPECGTKVDGFHQDEFGRCDRYVRCQGGKYIGTVKCAVGEVFDGSKGGCVPQEKACGPCGRLDHCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1P1</accession>
    <name>A0ABY7G1P1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SSPO-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_012690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF386">
        <property type="entry name" value="HEMOLECTIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFD" evidence="3">
        <location>
            <begin position="30"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR26986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="140" mass="15236" checksum="4A92DD9CF68FB555" modified="2025-10-08" version="1">MERRKTPDARQCKTCQDSKWQTEMADECPGICSATGESSFSTFDGKMFSFSDTCEYTMLVVGDTSVTQQNVPCGSGGMRLHLFLDEAYANQVAGLCGNFDGSNTNDFKLKDGSTTGNPHGKICGLMGYVTRMPKPNTVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G438</accession>
    <name>A0ABY7G438_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_013612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tumor necrosis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471:SF13">
        <property type="entry name" value="TNF FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471">
        <property type="entry name" value="TUMOR NECROSIS FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00207">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50049">
        <property type="entry name" value="THD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="THD" evidence="6">
        <location>
            <begin position="177"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR27908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="326" mass="36851" checksum="965DC2ED9EBF8442" modified="2025-10-08" version="1">MSPSTNIKVFAFASILITCILCISFVSIISSLAIKISQKSIKYATNMCVSCDELQSFPGFPAVASEDIDRIRSAKNKSSCCSSTDVILRMQIQKKMDEQVYEYNSGLATGNENLNNPFRIVNELKDINKPELSGVSLLCTGVSFSQSLTLSVAFSETITHILGKDNCDLVQLDENVPRAKVVGVVDHVWSSFQTDLRKVRWKKNGASATYGNIIHLEEEGEIFIRQDGTYIVLSNLRIHRDPSTPFATNFSHVLYQFSHRDGSETILMQRSRTLCNKSDDQYDSYISAVFRLHKYDRISIHTTHAQHLQINDTENFFGVFFTYDMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G477</accession>
    <name>A0ABY7G477_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="217" mass="24281" checksum="D6D0D61ACDA2873C" modified="2025-10-08" version="1">MKRSESLCLKKKLTKLESNTEHRSLNIFSLNQAVPKTAHNKTMVEMGDEDAIPVPTGNFVEGFGRGRVVRASKGERPEGAIRLTRDEVMKYQDARIRSWEPQSDVWFHKYGFSFSLISASASGYLIMAYLRRKFCLGASHGRIASFAPVMVLPAVGAVMMSDVQRRTLLSVPNCETCVKFSLGYTLTDKQAVEVDVITEKEAHRAAVNILDHLDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4C9</accession>
    <name>A0ABY7G4C9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P52K-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="32"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="147" mass="16987" checksum="6590D38DC4A0266B" modified="2025-10-08" version="1">MTSSCLAASATQESMLALLDFYRDDMPQPDMFAQEVQLWKQTWRNTENKPSTIVETLTETCQHMYPNISKVLTLLLLTSVTSAGVERSNSSLKFIKNPHRSTMGQSRFNALMLLFIHRDIKLDIEEIVNIYARKYPRRMLLIDPLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4Z5</accession>
    <name>A0ABY7G4Z5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR28982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="198" mass="23844" checksum="D19C803B23450196" modified="2025-10-08" version="1">MELSEKEEEIKRLEESVKRLDVVNQSLTMELSEKEEEITRTHEEERTDLYEEVDQQVQAHRRLKQELDKEIKAHKREKAQLLEKIRRREEEIRKDRSKEKAVEELGEKLREQRRIISDLDSKRLQEETIQQLQDENSRLRDEMSKITKPKQSFFTSQRQSLVQSTNERVISVTVYTTENLEYKTYSIIFDGEVFLSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5D5</accession>
    <name>A0ABY7G5D5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shieldin complex subunit 2 first OB fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd04491">
        <property type="entry name" value="SoSSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049507">
        <property type="entry name" value="SHLD2_OB1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21669">
        <property type="entry name" value="SHLD2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shieldin complex subunit 2 first OB fold" evidence="2">
        <location>
            <begin position="632"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR29643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="834" mass="93447" checksum="566F071793A573C2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6A3</accession>
    <name>A0ABY7G6A3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">POC1B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_012520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR26816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="242" mass="26536" checksum="83FEAE6930B677C8" modified="2025-10-08" version="1">MTRQLNSGTEIAKSVSTHSMNMEAHSAAVNSLSFHSSGNYLLSGSDDGQLKVFDLLEGRLFYTLHGHQGPVLVWKTNFDQVDFTELLQSHKQRAGENGAPTVADIAPKVQRPSSAGAAKSAKGGRSDIKSMDDAAPEVTEIGPAMFSSNEPASFDDVEMRSSDSRPRSRGDDFQPRSTTQPLEERGTMPPQLAGTLEHIVGQLDILTQTVSLLEQRLTMTEDKLRECLDNQHQLSQQVRQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G754</accession>
    <name>A0ABY7G754_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CADN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_003538</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR29970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="326" mass="34624" checksum="1EE6A377F3263163" modified="2025-10-08" version="1" fragment="single">EGHWGPWSTYSACSATCGSDVTRTRLRHCISGVCPTGNSSQSIACHMSDCPVTAVDGHWSTWSTSTCTVTCGTGLATSTRTCTNPAPSHGGQTCPGSSIRHSYCRISSSQCSVDGQWSTWSAYGACSDTCGTGQMSSHRSCTHPAPSGGGHNCVGNSLRTQSCTASQTSCVVTSHNNECIHYIEKYITIDNTEKRNRHIAKSTTYGGGQELFEELKISFSGVMDGNWSSWTTWSTCSVSCDLGTITRTRSCSQPAPSIGGRACIGDTTETHECTNGPCPEWSHWFNGDCSVSCGTGTRERMRACSTGNNHDCAGTSYETLPCDGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G767</accession>
    <name>A0ABY7G767_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="57" mass="6533" checksum="8BA58D1AF5CE174D" modified="2025-10-08" version="1">MSSYVRAMSPIPLLSCPDIVHPKRYYTAPQSSNGTSVFHHRSKSAHILGWKRHRKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7F3</accession>
    <name>A0ABY7G7F3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">VLDLR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_032892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR30350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="193" mass="21446" checksum="D5141D9201E17062" modified="2025-10-08" version="1" fragment="single">MFVFIEHVCSQFPVKDRRTSNSFMELKPSCAHHLYYLLRIISICADTIECQPGLFRCDDGSCIEEIWHCDGAKDCDDMSDEKNCENYQCGANYFACGNGTGPCISKLWVCDSDFDCSDGSDESPQQGCVPRHTYCGDPMIECLNGSCLTQEQLCEGFTCLEYVPDISGLTCAGITCADHQFQCLNGICIDKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7Q5</accession>
    <name>A0ABY7G7Q5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRAM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="223" mass="23910" checksum="6B157C1B4955FF50" modified="2025-10-08" version="1">MDNLSAMVNRTAKVILPAIYNTTAINNLTAKIDNLTAIDNLTIIENLTDTLTANGNLTAMVNLTAMVNLTAIGNITANGNLTVMNNINATDNLTAMFYITVIDNMNAMFNLTAVVNITAMDNQTEMVNLSAMVNLTAMDNLTEATTWLKPDCNRQPDCNGQPNCNRQPDCNLTAIGNLTEIDNLTAIANLTAIDNQTAIDNQNAIDSLTTADNHTAIDILTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G813</accession>
    <name>A0ABY7G813_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR29554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="245" mass="27992" checksum="DB363E548D012E6E" modified="2025-10-08" version="1">MEEEASQYVGSVLTTNIAEKVDWTPAKHPDNPCCRKRSLSGANEDESEEQSKKIKTKTIQCDAITVESFDTNALLLQLSRDVKLVAETINHRIDMLEEKISDSEKRITEQVSNNITKVFDKRMSSEMSRMRKDMDNKIGDLRKEISIIRNLPFNEPEDIDRKLSDLLRNGLKIQDVNLVKVERKKALSDSTPGVVVAKCNSLEDKNHYTCNSYGEMLLEFLFDVNFAMLNGRDCLKDDITCVRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G990</accession>
    <name>A0ABY7G990_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FBP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_003672</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="232"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="281"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR30104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="330" mass="36711" checksum="D0378A09D4EE5C20" modified="2025-10-08" version="1">MYEHARWFPTCPHIVICKGKDYVEKARLGEHPSISKQKEKVNQSDEQESSISRQETAMEAAAEFGYHMDWIRIAARIYSEREGPNSQFQASDLMSILMEMEDDPSMAINYTAGSGSCCNTTGDGNDVIADNMTSYGVSDAICFPNEYGPHCNFCIPHDTCTEGHYTCDVYTGNRLCLPGYTGVDCLTKIDTEAEVVEYHVRCPENECRNGGFCTSGRCCCNPGFKGDLCEVEIIECQNDSCLNGGICKDLVNGFKCLCKHGYSGSQCEVNITAHAQTQPPRDSNCQSRTCMNNGTCFELDVFVYCVCPLWFSGDNCEKDMRPSGMPIFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAX2</accession>
    <name>A0ABY7GAX2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="193" mass="22459" checksum="782C9E03D28BCD62" modified="2025-10-08" version="1">MSGRFPITRDVTEPHSSRDTVYVGWFRFKISFIRYPNSADVAKNKSSFFTLRTSCNSNMDHGTLVVIATIVLFYVTSSLAMYVPLDDDTDLPPQFRDVDLDTEDTAHLRKLLLKKLRFREILREQMQSPEAVLGDVDMAEDQIARHKASKRHKMDNLMDRVKAYLSQYKERQIKESMSLPSLRFGRSGINYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBK7</accession>
    <name>A0ABY7GBK7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUBPL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_033516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR30974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="228" mass="24550" checksum="99C00C07DAC08E4E" modified="2025-10-08" version="1">MKIITRNVLHQMRRMSTHDNPFGVKDGLSDHQQKLMARGLPQRRPIDGVKSVVVVASGKGGVGKSTTAVNLALAMAANEPKRNIGLLDADVYGPSLPTMMNLQGEPFLDDRAVIVSTPQDIALLDARRGAEMFRKVDVPVLGLVENMSVYICPQCGHQEHIFGQDGAKGLAEDMGVDILGSVPLTRAIRETSDSGQPIVVSDPGSPQATVYRDIARTIADKLSTLEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBX4</accession>
    <name>A0ABY7GBX4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SEM5A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_033148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF21">
        <property type="entry name" value="SEMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR30606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="156" mass="17817" checksum="C2F8B191E23B759B" modified="2025-10-08" version="1">MVAGQICKDRRNIMCLVGKGDNNITVNGGWSDWQSWEECSASCGQGRQQRHRSCDNPEPDMGKPCLGEDVEYRDCTVRECPASLVVMDHAQGEDCVILLDLSLVEKIAKMRVYKWRHVTLELAQVKFKVCSKYYLLKHSDLDEKYFCIVHVSLTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GD38</accession>
    <name>A0ABY7GD38_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_033705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="287" mass="33041" checksum="0CCD6EA87A65032C" modified="2025-10-08" version="1" fragment="single">TLKPWKPDNSEYKDLGNEEEDLDHHETYKIRCFSYYELKQSNGRYLGGDNYYTRKVEVENLNGALKYDGEKDANTLSCVEKRCFQLDQSNYPNVVIQPKTKYVEHGESYHLSCENGFEHSLKSDPDFMCSSGRLGGTTPHCKETSRCELPNDPYASYYVNDEIHRGNYTISHEDKVDRVECESGTSLTKPLDGRNRCWDGNWKLGAELPVCKPEHCDTPTIENGVLLNWIRWVYSNPIIVNGDSVSLQCSEGFFLYDNSKNEFMEEHVFRIKCYRGNITSIPSCIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GFJ1</accession>
    <name>A0ABY7GFJ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZMY19-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_034238</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032978">
        <property type="entry name" value="ZMYND19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46831">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46831:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13392">
        <property type="entry name" value="HNH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="166"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR31696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="218" mass="25091" checksum="52FEAEE94A1FCAE1" modified="2025-10-08" version="1">MKLKLVFTKYALLDERDISLVDSHAFEARTEIDQDGTGARVFAYTYSVKSGLNHGQERHNGGVAVGWKVIHRNNITVDNRLDNLVLVPESCTSVPHSDEDQCSKLGKDGSLYWLAVQQLHVDPVYQHFHEPVCSRLLDRDGDTVNEEVTVLETSSVLFYECHYPPCTNMEKHLREFSMCGRCQSVRYCGLSCQQRDWSVHKQYCRENRRPDLTEIPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DA19</accession>
    <name>A0ABY7DA19_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_006970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ94499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="328" mass="38258" checksum="561AA04C9C469BEB" modified="2025-10-08" version="1">MDAPMVKVKVEEINDEIDVESQEREHFTRILNSFRSYRTFCQRRVTDTLRYYEGLPTHHKQLIPNFLQHLTHVQWCICENYDVLKLIIQDVEHIFENKQNAANAGEDEPTSKATLPKISDMDKLKSTLRQFVRDWSTDGQAERDVCYTPVIEEIIITSLAVTLHKCKEINNYTLYPWVHQWTNNLRNEDQVRAITFPDVDTSDLPENASFSMAAGNFLEVYEDPVFFIDTAHNIIAYVEKIFEILKPGGYWVNMGPLLYHYADMPNEVSIELAYEDVRSVIEKMGFVFEMEKKNIASTYTENPASMLTHTYNSVMFVCRKPVMKEEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAG3</accession>
    <name>A0ABY7DAG3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CG025-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006393</name>
        <name evidence="3" type="ORF">MAR_006394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010733">
        <property type="entry name" value="DUF1308"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07000">
        <property type="entry name" value="DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1308" evidence="1">
        <location>
            <begin position="73"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ93922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ93923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="213" mass="23703" checksum="F8F0AEE95D74295B" modified="2025-10-08" version="1" fragment="single">MVTHENHFQSNSDLQNELPEKSDFIIAKWTFGGVSMLNFIEDELLINPLVNYSPMVSVLQQSKINTVDRIARVNLDVTALITLVSVVAHGGCYFRCKEKILSEQASEERESPVLRKLTSFLYQYDIPLFECQTAVDIFTSILETLGGPGEKRRAEDLLSRVNVVPNNPSFTADVMPNTGKIKDRSKVIFGTGDSLKAVTVTANSGFVRAAHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAY5</accession>
    <name>A0ABY7DAY5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GVIN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_007283</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030383">
        <property type="entry name" value="G_VLIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057365">
        <property type="entry name" value="URGCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052986">
        <property type="entry name" value="VLIG_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14819:SF25">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_52, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14819">
        <property type="entry name" value="GTP-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25496">
        <property type="entry name" value="URGCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25683">
        <property type="entry name" value="URGCP_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Up-regulator of cell proliferation-like" evidence="3">
        <location>
            <begin position="798"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="VLIG-type G" evidence="4">
        <location>
            <begin position="1137"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ94812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1373" mass="156879" checksum="2694BF45B0B99DE4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DH14</accession>
    <name>A0ABY7DH14_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_028058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="entry name" value="Serralysin-like metalloprotease, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051897">
        <property type="entry name" value="PG-associated_BURP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31458">
        <property type="entry name" value="POLYGALACTURONASE 1 BETA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31458:SF2">
        <property type="entry name" value="POLYGALACTURONASE 1 BETA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="Adhesin YadA, collagen-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ95368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="582" mass="60986" checksum="1312596414F4B7F2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DH36</accession>
    <name>A0ABY7DH36_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PFD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_029696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd23164">
        <property type="entry name" value="Prefoldin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ97006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="129" mass="14555" checksum="998F60F09C8D9D38" modified="2025-10-08" version="1">MASGKATGQKSVDLELKKAFQELQGKMIMTQQQLKISDAQIETLKRTVTRNLLVEKELGRLPENTRVYEGVGRMFMLAPIPNVLNTLGMKNQAAESKIKTIEGNKTYLERNMKESEDSLRELVLSKTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DH66</accession>
    <name>A0ABY7DH66_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">PK1L2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_029724</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01752">
        <property type="entry name" value="PLAT_polycystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042060">
        <property type="entry name" value="PLAT_polycystin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF150">
        <property type="entry name" value="REJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1842"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2033"/>
            <end position="2053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2073"/>
            <end position="2094"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2177"/>
            <end position="2203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2215"/>
            <end position="2246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2320"/>
            <end position="2338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2520"/>
            <end position="2539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2559"/>
            <end position="2580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2609"/>
            <end position="2629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2649"/>
            <end position="2671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2711"/>
            <end position="2732"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="13">
        <location>
            <begin position="23"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="11">
        <location>
            <begin position="150"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="12">
        <location>
            <begin position="1868"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAQ97034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2841" mass="319458" checksum="317A50FE71512243" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHH6</accession>
    <name>A0ABY7DHH6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SPHK2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF112">
        <property type="entry name" value="LD11247P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YegS/DAGK C-terminal" evidence="1">
        <location>
            <begin position="228"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="338" mass="37528" checksum="77E1139BE683D28B" modified="2025-10-08" version="1" fragment="single">DPDGSCYDRTALVSRLLLPFRVLGSDRGHRLREREVQGHRGSQIYFAGFKTDSYKGRLSFLPVSEYIPKSSNNNTTKSLHIPTKNRRVSMDDFENGDNDAYDRLRTKSVPWKLYNKKSFSESEEVEEKIDEELADVQESMASGDALPENTGSDEKSPANGEIKFALETENNLDNMVSGNGKPGDTSSVNCVQEVIRLPKSVDGKIPSILPPLDKPLPSDWVTLDEEFVSVAACYQTHLGSDSIMAPDARFNDGIIHLSFIKSGIQKGELLQLMSLLEKGTHIDFPSQYIEMVKCLAFRLEPEGKEGIIMVDGERVDYGPLQGQVLPGASNLMAIHCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIS3</accession>
    <name>A0ABY7DIS3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S43A3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027197">
        <property type="entry name" value="SLC43A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20765:SF1">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOBASE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20765">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 43 MEMBER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="538" mass="59384" checksum="1D647776136211B0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIS7</accession>
    <name>A0ABY7DIS7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HBAP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_029803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play a role in cellular stress response.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF43">
        <property type="entry name" value="HSPB1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="4">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ97113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="450" mass="50247" checksum="231AC435F9A4BB3B" modified="2025-10-08" version="1">MELSGVDWSVFGLLGRDGADSTLWVGSGGTYTPCHQDTYGFNLVAQIQGRKRWYLFPPNQTAQLYPTRVPYEESSVYSQVNIRAPNLSHHPKFKQCTPYMIELGPGEVLYVPQHWWHFVETLEPSFSINTWVPLASDSSSHVEESVCRLLFSSLASHLLSPEQIHACLNTGESLESSKTDMQYVKMAVHNHLSESSPTRAPPDNLHMVRRHFQNHTVESLSPCGCLKVGRKRKAESNEEHEWKLLCSGSRHQKPCVDSSDSSESSISSAVDCSKTASTVDSKLRIRKKEIVQRQTNDIQKQGASKLNDDGTKETNINIVALSPMSFDKFCTFLKGTFGYNGFDNLDSAATGVPITDNTGKMVNVVTDITEGVEQEEHKHTKTWHKSTVENVESVSCETESEHESCCENKNLDDISLQEKISNVSEIDVIKAVLHPTVITQICKLLTDDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJ42</accession>
    <name>A0ABY7DJ42_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_022095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ97722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="207" mass="23749" checksum="6878E7198FF9AD85" modified="2025-10-08" version="1">MSQYGIGMYKKRNVPITHANVSRENAIELCDFAIHLNDETAFPHSDSLEDIFLNTMTFGKNNLKMIWNLQEKVSVMLNRVAEKDYCLIGNSTTNISKCWMAIHAKLDGGRQINRCQRSSWNTRCCWGALRFFVGPAWSPMVFQEVMWCEADTKKNRFMQAIKTIREVSQSNANEEITFNENKCIKKANLDCGQPFDDTPDTSATEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DK16</accession>
    <name>A0ABY7DK16_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CP1A1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_022390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF417">
        <property type="entry name" value="CYTOCHROME P450 508B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ98017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="262" mass="29462" checksum="5698E3FA7F0D197A" modified="2025-10-08" version="1" fragment="single">MSTLTNTSVSSLIVTLHLFDDVAMSQVAEHYESRLDGNIRDVADSLIAAADELKDSGDSCYELTKGRLLNVLYDLQGAGVDTTSKTILWLILYMAKYPAVQKRVQDEIDCTVDQTNMPCLDDKPHLIYTNAVIHEVMRIETIIPTSLPHYAMKDSYIQGKKVDKDTVVLFNLHSLAYEATVWGDPTNFRPDRFLKEDGGLDIKMTAQSHPFSLGRRRCIGEQLAIMNIFLFFSGLMKKCTFELCENPEVDTIPGLVYAPEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKH3</accession>
    <name>A0ABY7DKH3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_029776</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="4">
        <location>
            <begin position="27"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="4">
        <location>
            <begin position="134"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ97086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="279" mass="30291" checksum="0E999C651A131E7C" modified="2025-10-08" version="1" fragment="single">NFMNICRPYFDQSLAIDLSWKEHNVSGRDIVVGVTDVGINTDNVYLRENIQLDLSYNFVDNNSNTIPTILPGIIGSLHVTNHGNACAGLIARPKTNALCNPCGLGVAYKAKGRNGLGSVYVFPAGHPGSGLVNYVGSIPVACMDVNGSVADVSQVNAATIVSVFCNGRRRIDDRMITVGHDDRRCFTEFGGESAGTAIVSGMIALLLEANQNKSADWYVLDFCDTSPCIEKMEEVLFQMKFVYSELHHMRLWAKSPSGTVSELASIEPRLKGSKITIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLB4</accession>
    <name>A0ABY7DLB4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_022356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045465653" evidence="3">
        <location>
            <begin position="19"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ97983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="418" mass="44975" checksum="E65E411805EE9A7D" modified="2025-10-08" version="1" fragment="single">RIWLYSLSAILQVELGAGDGTFYVSLQKYENQALIDCCKNETRPEECVCSLSFGVVVTGLNSSSAGKEWRSPAALTPSDATVIDHEDQFPNPLSYNFTRWECDVNVTVKVYKGSNSSDVVDEFMVTYTDSFPRVWFMNQTITTNNSASATFITRYMCGKGHENVGDCVDSNLTDTCQTPSSTVTYFPDTVTTEETTVTTETTAPTTTTMQDTTTEIVDSTTTEDPTTSTTTTTSTTTSMRPSTTTTVTPTSMTTSTPTPAKTSTSTSTTTTTKTTTTTPPTTTTKRPSTTTTVRPTSTTTSTATPANTPTTTRKQTTTLSATPTQTAAKTTPKGMTRDPTDGTSQIDDNNAAYWPAIVGGILGAVAVFAATGFICYFNRQNTGYVPEFTLLLVSTGYVPEFTLLLVSTGYVPEFTLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNN3</accession>
    <name>A0ABY7DNN3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FBN3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_022348</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052080">
        <property type="entry name" value="vWF_C/EGF_Fibrillin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333:SF4">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333">
        <property type="entry name" value="VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="120"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAQ97975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="586" mass="64525" checksum="133E9AE23E3F976B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DU01</accession>
    <name>A0ABY7DU01_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="193" mass="21390" checksum="1262B74DDDF69068" modified="2025-10-08" version="1" fragment="single">MVCMTLHKLMRTRYPNIQNADLDREDEQGQFIAGAWRDQAVLEDVQAAGNGPYIYTSRDIRPGYGRVPVEFRPSIGRCPLHLSATGTILSKALSHIGRSSVGVRPMHGTPADTRPCTGRRVFRCGYDGAAMRELGESPVKFSSEVKISPSCHRCGFKQQTPRMSGRCPAGVRLQFSPWEYTYIHSVTGTACVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUV2</accession>
    <name>A0ABY7DUV2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WDR49-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_023078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051242">
        <property type="entry name" value="WD-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324">
        <property type="entry name" value="WD40 REPEAT DOMAIN 95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324:SF4">
        <property type="entry name" value="WD40 REPEAT DOMAIN 95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="234"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="403"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="556"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ98705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="728" mass="82632" checksum="0537B7195CDC0ECA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVL3</accession>
    <name>A0ABY7DVL3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DIS3-like exonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_024496</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF30">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="6">
        <location>
            <begin position="557"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR00124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1074" mass="123111" checksum="4C014141ADE61C84" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DX79</accession>
    <name>A0ABY7DX79_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_008057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="269" mass="29257" checksum="E193A6539E9A37E9" modified="2025-10-08" version="1">MWGMDLGECGRELGGNGGGVYGLSAVGWERGCLGYVSGGEFSGGGALDELDGEGGLDDWYGGLTPPSDITVATAPGNTLLDSSRMLSIVAVVEEMGKSNRYKSDIDCSFYETSKDVPDPRELSTDNKNLMIFDDLLLEKQNKCESYYIRGRHSNVDCFYLSQNYFKLPRQTIRENANFICLFSQDLKNISHIYNDHVSSDMTKDHFNFGRTKAYQNGKEVTIRHNLKVEGDFLPMLAGLAATVAPILLKTVLSALGVGAMSGLASTGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXT3</accession>
    <name>A0ABY7DXT3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="24159" checksum="EB47F60B4CADC69F" modified="2025-10-08" version="1" fragment="single">HIYKDRRATVRSIGDDLDISSSTVYCILTDKLGVSKVSARWVPSNIGSQTVEQSMLIIIQRFLRRDRIQAFRKKRLNADHDRIILHQDNAAAHKAASTQLEIGLLGFELLVHPPYSPVSTSDLMQTTQRIISTLDKESYVETFTIWISRHRKCVNTDGDYVKKNNKELKLCRQLMSTTSTITSIAKVIIQFREVLEQTSHLTYASRDQNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYN3</accession>
    <name>A0ABY7DYN3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TPC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_009413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028801">
        <property type="entry name" value="TPC1_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46474">
        <property type="entry name" value="TWO PORE CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46474:SF1">
        <property type="entry name" value="TWO PORE CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR02855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="177" mass="19754" checksum="8611173C8A0CCE32" modified="2025-10-08" version="1">MAGNADDSQLLSEVNADLPDVYDLNDGSQELVIGGGNLVLQVVDDIPAERLSKNWKLNHLEAAIYLQEGENNDKFYTHPKGHEALPAYQIAHNKWFHLLDFAASICVLLLAACERPAVDLIKLPVGVHGSLEILMLLVLSLELAIRMKWLSWRVYFRHPRTVIKDSSSSPPVIATYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0P5</accession>
    <name>A0ABY7E0P5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SFRP3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_008966</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the secreted frizzled-related protein (sFRP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018933">
        <property type="entry name" value="Netrin_module_non-TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF96">
        <property type="entry name" value="SECRETED FRIZZLED-RELATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01759">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00643">
        <property type="entry name" value="C345C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="11">
        <location>
            <begin position="87"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="12">
        <location>
            <begin position="229"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="347"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="87"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="95"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR02408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="414" mass="47714" checksum="B9952873157F626A" modified="2025-10-08" version="1">MLRVMEFCEITRTVDHPSSIRCKSDSQMFIRYGIRDPNCRAHGRRCFKKNTSLTLIRRPTFLATILCLIHLVTFAVTTDAHRGLDMCEPIEISMCSSMPYNMTRMPNHLHHSTQENARLAIEPYGELIKENCSADLLFFLCAMFAPICTPMFQKEAIPPCRSVCESSRHGCEPVMNQYNISWPTDLNCDRLPEYDKGVCVSPEAIVSSMPEGETPNEKSKEKGKEQTECSCNTRIKPNKKVFKKGKYDYAIGALIKHITPLGANATLIRVTVNSILLRGKVHLQERRDINLLAGSSCVCPALRTGRQYLIVSREDVMMNRLLFTEDSLISRWKTKWGTKFMRWVKEKRGKNKKRPCKNKKSKKCRRRKRRCRHQPKDESKAVRCARPGKNNTPNRKNRKKKKENVNTVTNEARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3J7</accession>
    <name>A0ABY7E3J7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF37">
        <property type="entry name" value="OS05G0311600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="182"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="259" mass="29710" checksum="B3ABF381B3419200" modified="2025-10-08" version="1" fragment="single">MSGASKGVATNISKKEPRALYTHCYGHALNLAVSDTVMRSRCSEIRLTQYTIQTTENATEIRTRNRPIRFSSYRKRPLPPYLQRGTRSCHGNHQRPLRTTRLHDIRHLEDMLLESVRGDASFRDDMEYIVNLYGCDLNRMRPLTQLEMLSVHLSESMKDSGIVTLQDIVSELRALASRELFTEVVTVVKLILVMPATNATSERSFSALRRVKTCLRTNMTLERLNHLMSLPTQRITSQTCALLIRRHEIIPDPKMPQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9B1</accession>
    <name>A0ABY7E9B1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045779706" evidence="1">
        <location>
            <begin position="18"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="65" mass="7073" checksum="00BBB0A131B0CF8F" modified="2025-10-08" version="1" fragment="single">MMFHTVIFFLASTVTYAFVLDDVSPTGSNGLPALAEPPLRIGSFNIQVFGITKFSNKPVVDILVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9S4</accession>
    <name>A0ABY7E9S4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CP2R1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_010454</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF1">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR03896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="491" mass="56014" checksum="4CAC2FA2F95D5929" modified="2025-10-08" version="1">MATLFNIVQSSYEVMFKYRGRAVLWMYSGGRSASALPGPRGLPFLGSLLDVDTSRFHHVCSRWSRHYGKIFQFRLAGQSVVVVTDAGLLRRLFATGQISHHTNDRADNVTKHVFYGRKHIGFADLGERTNELRSILRRKVLNRLMCDRNFENTCFSIIDKLAHGLNHESVNPDTLIKDVIQELNSFVLIGEALPADDPDKDALWEFIERLYDLLQPAVDVPLRMFPWLRFLPFKHGRLFRAAIESRDRVSRKYFDTQKASYEAGRVRGLVDVCLQIQAEEGTTSGDQAWLSDDYIRGLMFDTVLAGMSEMMKSMRMLILLMCHYPHVQSRVHAEINDVIGTSAMPSSNHRMEMPYTQAVLLEMLRYVSQTPLAIPHKCNKDVVLDGFVIEKDSGIFPNIFGIHHDEAIWGDPLIPFSVGRRRCPGEDFAMTRLFLVLTSLIQKLHFLPPSSGELPSADPRLYNNQYPLYLPVFTCKAVRRPVMDAQTESQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EA51</accession>
    <name>A0ABY7EA51_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_020875</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR05506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="384" mass="45322" checksum="E0B132D323FE72DA" modified="2025-10-08" version="1" fragment="single">AKEQQEPNRTEQVVLQNPKPHKPDGFTLAKHVRDQCGPTADKYPAEANEQFWIGRMHVIPAQKSMYCPVEKVGTTFWRRFIYQVLHPRKYRHPFQVPIGTALMADYPKPQKGATRKDISDLFKFMFVRNPYHRVLSAFVDKVFVPNPLFWRRFGKPSIQMFRVNDSRECFHDPTFAEFVQFVTWSEKNKKMIDPHFLMSTEMCLPCASNFTFIGKMESFKDDSLVIFERFNLSSLATSMEKQMKTYAAEDAISDSISSPFAWKKSIVSCMAWYDALHRIWRKLQLRGLIEFDIKMPLNEKQAEKVTRAEMIKLANEAWKKSNPMKLKEQKTIAFNQFYMSVPLRALNELKDVFARDFYLFDYDKEPPEIFDRKREYISVDYALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAF4</accession>
    <name>A0ABY7EAF4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897:SF2">
        <property type="entry name" value="OS03G0226600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897">
        <property type="entry name" value="OS10G0105400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="163" mass="17598" checksum="D3B70A09D911800B" modified="2025-10-08" version="1">MAVNGAGLRTVSHSEQIYIDLTPPEFEYVYDGDSSDFDIQFQTSLNISMAWSVKDPESGIQECSWAIGLSPMDTSLQDYTQIAITENVASTVISSTPYDRIFSTMRCTNAAGRTASISTDGLKISLVGVDTSFSETVVGSTSDVNFASFTGLNLEDGQYKVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAJ3</accession>
    <name>A0ABY7EAJ3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="633" mass="72110" checksum="882E3E82CE9ECC73" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EB11</accession>
    <name>A0ABY7EB11_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045071967" evidence="1">
        <location>
            <begin position="21"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="547" mass="61437" checksum="6972A06748F3E985" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBE9</accession>
    <name>A0ABY7EBE9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="104" mass="11955" checksum="5FFBD91431730F0B" modified="2025-10-08" version="1">MRSLDKRFSLTEAEGQGLRPDCSAEPPSRRSSEALQDGQKKQHNKAFRYNLRLKLAVIEGVRNMYYDFAYSKADRVAELRRELFDESVEIVSGSDSEYSSDDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBP1</accession>
    <name>A0ABY7EBP1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4773 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_019940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031941">
        <property type="entry name" value="DUF4773"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15998">
        <property type="entry name" value="DUF4773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4773" evidence="2">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR04571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="162" mass="18413" checksum="E9DB51753E5F72F4" modified="2025-10-08" version="1">MKPWTQCIHNSCTSCLGTTLKVNKTFKLQACGTVEYKRGREYLIGLTINGYRTYYHQMRLINRTNVCTPVPGLGKNKSLCFQIYNVRGRRMCTRLLGNALINGKHVNGSIEYGCFRIPCLDQGMSGDNCDVPVENDEDDAVTEEWREPTDKDGMDNDFVIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECJ1</accession>
    <name>A0ABY7ECJ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="190" mass="21051" checksum="F7B7E92E6ABEF832" modified="2025-10-08" version="1">MAALLGRTEVGVKEFGRTVTIPDDPKASLMYYLDCICVILDMSATANLTKLRNYKRYYMLTEAETDALVSLCFLLSPDELNGKVIIQDDAMCGDSYNAFFEISAVRHDLLVTNSILIGGQQRAVSKIMAYRHLWILNYWTTPMKAFAGRLARIAAGSAAPQQWPATTYNQPATGQQRSTDTGDDCCCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECZ6</accession>
    <name>A0ABY7ECZ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="204" mass="23554" checksum="9FAE798CFB062605" modified="2025-10-08" version="1">MTTFVQPLVLKIVSESRQHISSEDVDVNGTDAILSYGKVVLELGLIFLELCDIVKSPSRICLLCHMKYIMLVLKGHKNKTIIPADLQMEHIVRLTKGHLRSMGSNVTDKSLVKRSSAFFGMEEISNNFDKKTGVVQRAHKQKKLSSFVRMKNKRDLRWIKPFMEMCGRQSESLKKVPKNPIKKLDMADILKWILHHKMLLYYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EE26</accession>
    <name>A0ABY7EE26_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SENP6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_017145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="679"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="804"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="823"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="851"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="905"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="924"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR07187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1130" mass="126754" checksum="F03C3F7AB657D647" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEQ0</accession>
    <name>A0ABY7EEQ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="72" mass="8549" checksum="8A57F28D487FBB89" modified="2025-10-08" version="1">MNHLSSRNEIVCDFYEIAFKIWTIFIDVWSSDRKNLLYMYDICFEVYTQVLPSSLYAFVGNHCVNLVVCKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFY2</accession>
    <name>A0ABY7EFY2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="3">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_017659</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="3"/>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR07701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="577" mass="65063" checksum="C537509002525D61" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGT3</accession>
    <name>A0ABY7EGT3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_017974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="534" mass="60893" checksum="E45046FF5281D5EF" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHJ5</accession>
    <name>A0ABY7EHJ5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BHMT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_018229</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103:SF18">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="5">
        <location>
            <begin position="3"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR08271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="352" mass="38750" checksum="229CBEF3405C419D" modified="2025-10-08" version="1">MGKGLLERLADGGTVVIAEGYLLELERRGYLQAGSFVPEVVLEHPHLVKNLHEEFVHAGSDVVEAFTYYSHREKLRCIGREDDLERLNKNALAMARAVADDTGTLMAGNICVTGEQVDWAVEGGADYIIAESFGYLGEALLALNVIKEHGKGLPAVVTMAPYVPDVTLDYVPIPEACRRLEVAGAAVVGLNCQRGPETMLPLLKEIRKVCKGPIAALPVPMNTREDCRTMFSLKDEKTGELLYPTNINHFLCTRLQVRRFAEAAREIGVQYIGLCCGNAAYLTREVADVYGRKPPSSRYAADMSQNTMVGEEASRVSTAGDKVRKFCLGTFTKEELDEIERYMSGELVSEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIF0</accession>
    <name>A0ABY7EIF0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTBD6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="197"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="300" mass="33165" checksum="93935969535EA926" modified="2025-10-08" version="1">MQTTDCIVINCDARTHARTHTDKAFSAIMIVGAFVLPEVTCGITEASATRYFVLHLEDFIKADPTSPDMVNGPFPNKRYFAIDEKDSAFGPEVRQNIFISPSITSFLFPFIIVMTKYTYRLSAAAGICMLAFPVSSPPASSNNTLLLESSDNRAASTHPAEPPPTIMTISMDTKTDWRAGLTASGCLKYLGDEKLLTDVKFIFPNDNNESCTGHKLILSMRSAVFEAMFYGPLATEDGEITISDIEKKKHMVLRYVYSDELEVDGDTVLRCLYAAKKYCLDGMVRFCSDFLESSVTIVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIQ1</accession>
    <name>A0ABY7EIQ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="385" mass="42376" checksum="1DBA544BB7DE6099" modified="2025-10-08" version="1">MKGYSAEAISDGRYLKGYLAEAISDGRYVKGYLAEAISDGRHLKGYLAEAISDGRYVKGYLAEAIIDGRYLKDYLAEAISDGRYLKGYLAEAISDGRYLKGYLAEAISDGRYLKGYLAEAISDGRYLKGHLAETISDGRYLKGYLAEAISDGRYLKEAISDGRYVKGYLAEAIIDGRYVKGYLAEAISDGRYLKGYLAEAIIDGRCVKGYLAEAIGDGRYLKGYLAEAISDGRYVKEAISDGRYLKGYLAEAISDGRCLKGYLAEAISDGRYLKGYLAETISDGRYLKGYSAEAISDGRYIKGYLTEAISDGRYLKGYLAEAISDGRYLKGYLAEAINDGRYLKGYSAEAISDCRYVKDYLAEATCDGRYVKGYLAERPSVMVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELE5</accession>
    <name>A0ABY7ELE5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DZIP3-like HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="68301" checksum="EC0E91BA69062D5B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EME7</accession>
    <name>A0ABY7EME7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="525" mass="57492" checksum="7C77BFBEEC0F8D06" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESC3</accession>
    <name>A0ABY7ESC3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="503" mass="58100" checksum="E160EEA62029C0B3" modified="2025-10-08" version="1">MLIYPVTLKAIDRFERQNAIISVNVFGHENKDVYPVRISKHEHATCVNLLLIDDGEKQHYCLIKSMSRLCLNSFNSEESLGKHKGYCDSNDAVKIEMLEKGSTLKLNTFSIPFIVYADFEIFTPKLDTAQPNLDESYTKQHQKHTPSGFCYYIKCFDYEVYKRINLKQNPVIYTKQSEDEDYVIDSFTNKKGEEKEVKHELRFINSFKFMASSLDKLVESICRKKYNKAAIAEYNTAKEVVYQHIKELQNPISNALDIGEFDILKDLIDEKNELKKLLANLEIKYEGEQLSLAQSAQRFALLIHKGIYPYDYVDGLEKLAETQLPPKEEFYSKLSGDNISDEDYVHAQKVWKDERLSQSVSHVRCIASGEVFETFRDVCLTNYNLDPAWFYTAPGLAWDAALKLTEVELELISDPDMLLMIEKGIRGGVSNIMTRYGKANNKYMGDEFDPKKDSTYLQYLDANNILGLKITKIHRGIKFIESTWLKKYIDLNTSLRAKSTNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESK4</accession>
    <name>A0ABY7ESK4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_026302</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="68"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="389"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR12122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="523" mass="60205" checksum="FF4CB388AFA6A4CC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWB6</accession>
    <name>A0ABY7EWB6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR14145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="308" mass="35243" checksum="1047430FA76393D1" modified="2025-10-08" version="1">MATAHNKTRTHLDNIHHAQAQRDKLHKSQSHGEKVHQAHTCSDTLMRTQSQWSKLNFQALAHRKVNTRHHRIDTKTQDADINRIKTTGKPFCVYVNITLVRNMYTRCRYDLHNIAGSLAPEHVCTDVKAISEVFEKSAYEHIGYVRMLSWFVSITNGTCTLVDELLHCVAESIWREREQIESCVLHMRSALRDTHASSMFPAYPFKWKFCEVVWCENFHKFTDAQVACFVRCLLGPAAICIGGVLAFLCLGTAVGRIFNNSFIAWCIEALLGMIVAVIWIGYKPKLFTLFSVVNILKFVIDCDCCEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EX03</accession>
    <name>A0ABY7EX03_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HES4A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_004583</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd11459">
        <property type="entry name" value="bHLH-O_HES1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="7">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR14478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="336" mass="37986" checksum="72EE0D37B3F7C91A" modified="2025-10-08" version="1">MCSKMDDSGEKRQPVSSSNRRNNKPLMEKRRRQRINDCLVQLKSLVLQAMNKDTTQYSKLEKADILEMTVKHLKLVQRQQMTAAMTTDPNAISKYRAGFNECAAEIARYLDNVNGGNPDLKSRVMNYLGSSMLQFPVIPVYQGVPYHMQMTSQGVTSQGFPHQSFTPLSIPVATNTSFSQHYQQSEQLAQSSTVRNVNVKSQPLLISPIKIEPSQNDVTACSSHMTSPIARVSSPCDSDSGLSDSSTSFSHDENGNYSHFNVNNQRPEFESRLQQRPGPRSEFPHHVSNERRSSPKRKLDDAAGDGQRKRQNVNSSNFDLRQGRDNMVDESMWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXB8</accession>
    <name>A0ABY7EXB8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inositol 1,4,5-trisphosphate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MAR_027536</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the InsP3 receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd23280">
        <property type="entry name" value="beta-trefoil_MIR_itr-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000493">
        <property type="entry name" value="InsP3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035910">
        <property type="entry name" value="RyR/IP3R_RIH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13715:SF99">
        <property type="entry name" value="INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13715">
        <property type="entry name" value="RYANODINE RECEPTOR AND IP3 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
        <property type="entry name" value="RIH_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00779">
        <property type="entry name" value="INSP3RECEPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100909">
        <property type="entry name" value="IP3 receptor type 1 binding core, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="13" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2048"/>
            <end position="2068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2111"/>
            <end position="2131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2137"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2175"/>
            <end position="2197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2247"/>
            <end position="2271"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="89"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1600"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2420"/>
            <end position="2531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2599"/>
            <end position="2647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1602"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1664"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1676"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2425"/>
            <end position="2436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="2437"/>
            <end position="2448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2461"/>
            <end position="2477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="2624"/>
            <end position="2647"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAR13356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2647" mass="306635" checksum="C0AAA55C4E1EC5AC" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXP0</accession>
    <name>A0ABY7EXP0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR14640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="117" mass="12830" checksum="F463336D1B306696" modified="2025-10-08" version="1">MDETKIKELISESVSAKKHAYCKYSNFPVGAALLCEDGTIFTGCNIENVAYSSICAEQTAIAKAVSEGHTKFKAIAVSSNQTENFGGNWDVIMTKPDMTYKMMKTSELLPLGFIYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXQ1</accession>
    <name>A0ABY7EXQ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PKHG5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd13244">
        <property type="entry name" value="PH_PLEKHG5_G6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040181">
        <property type="entry name" value="PKHG5/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217:SF11">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="48"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="683" mass="77490" checksum="12761FEF51140201" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXQ2</accession>
    <name>A0ABY7EXQ2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_004177</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR14072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="398" mass="45274" checksum="66C0ACBFE88F291E" modified="2025-10-08" version="1">MLAGIDPNRLKLALEPECASIWCETLGMDVKGAVAFQGSQYMVVDLGGGTADISVHERKPDGTLKEIHKASGGPWGGIYVDENYMKMWKELFGEKALNDLRENEMNDYFDITREFEHKKRSFDTDKTKQIVVRISASLRDLSEKYSSESLEERIASLKVREHAITTRGKDKLKIDTTIVLSWFKRPIDLLIQHLKTLLAEPKIKSVRTVILVGGFGESPYVQERIRNEIAGVRLIVPADAGLVVLKGAVRFGHNPTIVSSRIIKYTYGTSVNVTFNEKKHPEERKVWINGEWQVPNYFKVYARVNTQVRVDKQMTRKSCPYGGKSLLSVYRTTNENPEYTTEDGCELLGEIELENSMDIPFEKQICEDTFMFGDTELLVKTKNTVTGKEAFMTFECFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZD0</accession>
    <name>A0ABY7EZD0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MPP9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_005380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026636">
        <property type="entry name" value="MPHOSPH9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14926">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14926:SF1">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="760"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1158"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1356"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="695"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="760"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="803"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="864"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1188"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1249"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1278"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1300"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1398"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1414"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1432"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1556"/>
            <end position="1571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR15275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1571" mass="175670" checksum="6BD7D01D92E5C4E5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZF1</accession>
    <name>A0ABY7EZF1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="100" mass="11350" checksum="D7F3C7119A4CDF9B" modified="2025-10-08" version="1">MYVSNVKNVENHSDTSSDNGVLHITTEGVQYAVVQRQAATQRIEPQQSHNDDSLTYAELDIKFLQEANARVPPRRKNTPTEYADIEFFLTQESAVDDPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F094</accession>
    <name>A0ABY7F094_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="157" mass="18512" checksum="B3E6984DEF374E3D" modified="2025-10-08" version="1" fragment="single">DNDKSRRTEYCNSGKNIRRSLAPEKICSTVQNIEEAFQKSACKPIGYITMLTWIVQQTDIKEMCTQLKVLLNCVAQSIFGWSELEKIELCVLHMRTALRNKRVDSMFATLPFRWESCERVWCQIRREYTDDQFRCIVRCLQIPAAKYEKTITVKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0K3</accession>
    <name>A0ABY7F0K3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PUF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C19 ubiquitin carboxyl-terminal hydrolase" evidence="1">
        <location>
            <begin position="507"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="753" mass="86305" checksum="B02459F0A7259855" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F218</accession>
    <name>A0ABY7F218_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IMT2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="362" mass="42869" checksum="FE37E7DAC034FBE8" modified="2025-10-08" version="1">MFLRRKIKALVFIIGVVAIVLVFGRVFDYVMLEFIFVSHANGHQCKHCLESEPPSEIPRHLHQVFFFETSDTVPENLVRARDTCLGANPGYRYTLWNKTSINELIDQYYPDVRRLYDSYDHWVKRADVARFDILRDKAKMKHHSIVVRRTEPVGFSNDFIGASPRHSFMAEVISSLLKANIWFVFPYPSTVLVTGPTYFWGRYLHFTRHDQFLILSNYTEYLGLIHGSSWHSWDGIIIWYFFNRAGFLILLILLALGVLGFFVYRRKLRSIRTRLDFNKNWLRLDTEKRHLDQIVVKRTSFCIVVLSQLYFLRNEDFWMFDSIKNAFILNLYQLISFLRIREATAAMILWIDAFFTAAIFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F325</accession>
    <name>A0ABY7F325_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NEP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF133">
        <property type="entry name" value="PHOSPHATE-REGULATING NEUTRAL ENDOPEPTIDASE PHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="137" mass="15379" checksum="2E21DF0FEE2B670C" modified="2025-10-08" version="1">MNYGGIGVVIGHEITHGFDDQGSQYDKVGNLRNWWDTTILENFQKRAQCIVDQYGGFVVPDIGIHVDGENTLGENIADNGGLKQSFRAYRKWVDSVGKEELPLPGMNLSHNQLFFINFAQGYRNATKLTRVFGNVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3D6</accession>
    <name>A0ABY7F3D6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTYE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_005441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="205"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR15336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="346" mass="39027" checksum="DED0D8E15F04B70F" modified="2025-10-08" version="1">MVDWMGKYFHSRFPGFIPELEALNSGESLLRGREMSDQSKHIPVIDFAQCGLQVLEEGLQTGDVSLVGQLLKEAFSTVGFCYLKNHGIDQQLVDKYMAVSRNFFEQSVEDKMKHATKVDSYYGWIAVEREKLNPERPGDLKEAFNFNPADDSDDWSDVEFQQTSMDMFQRCTELSQRICDALSVGIGLRRSFLRDAHKFAGKKGSATTLRSLYYPPIPEGSPLKPGQIRAGEHSDYGSISLVFQDDIGGLEANIHGTGYVPASPISGTVLVNIGDLLQRWTSDKLLATKHRVVVPENEIGGKKCRQSIVFFFYPDYDYLIKCVDGSDKYDPITGLDYLKYRYSITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4I4</accession>
    <name>A0ABY7F4I4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IF4G1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_004336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF78">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4G1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="MIF4G" evidence="3">
        <location>
            <begin position="119"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR14231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="479" mass="54602" checksum="C1B7D01FDB8AC1B7" modified="2025-10-08" version="1">MPRKSRRLKPGTSKNEMEEKDAVSESQGLPSMASQTNKPGTSPSEMNKPIKTAKVELHKAEKPWKPSCLKSSTTIETQDMSIKTTEVGLHKAKNPWKPRRQKSSDKELKVNADAIDDLYKKTLSILNKLTLHKFQVLVSRMKTLKIDTKDKLKGVVDLVFEKAICEPYFSEVYANMCKCLSKDSRTEKANEEVKAKHRSLGNVRFMGELFKLKIISQNIMHDCVFKLLRAKDPESLASVCRLLTTIGKELDTVKNKPRMDQHFQQMAKLANDKKNTARVRFMIEDVISVRLNKWIPQCSNKTPQTIDQIHLEVARERHVEKLQKSQKGETGKREGCRKGHTEAAQCFVEKGPDNTKDVNSTPATRTNCLTLTEIADRLHDIIVVRQEDNETVFNWIESNVEHATTAKSQFIRELMIAVCQSAITGLLRGYFDIFYDEDIITEDVFSESEEGENEPEGKTTALEQVVQFLEWLKEARADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F540</accession>
    <name>A0ABY7F540_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTPRS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="268" mass="31067" checksum="67C5A72B7A3D6C7D" modified="2025-10-08" version="1">MLSECDDISDEDDASARESAIIFEENGGFYFNNAEEISKIKLNVTDLPEYVHNLCFKDLEEEFQKIPYDDDTRVLVRGGETDYINASFIDGFKRRNAYIATLGPMTKQLGDFGQFWRMVWQQKVEKIVMVTNLVEGKKTKCEQYWPDHYQRNMFGDIKVVCKDEKLYKDFIWRNFTLFKNSKKRSLHHLQFTSWPDKGVPDDVTSFIEFRQRVNALASTFDGPVVVHCSNRFESVFVSSRPESVFVSSRSLSVLVSSQFESALVSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F617</accession>
    <name>A0ABY7F617_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR17320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="118" mass="13463" checksum="DC3D321D99F43BE6" modified="2025-10-08" version="1">MTIVVDCTVQKCIDPLVETSSISLCERKWEFFIIKWFAVLMKAKPLFSVGSRNKDCGNACCTGEAPRERQYEHALHVAYSLSIKMLVSKWSVHVDNSIASFALRRLIKRAVSVWNLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F710</accession>
    <name>A0ABY7F710_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MOT6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_031753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="52"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR17159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="478" mass="51286" checksum="06433EEDF2BCB0A9" modified="2025-10-08" version="1">MTVFVRPEASYHNFEREKLLSYKGSEAIENGYGTKEAPPLCVKHTSRSRKASVMLACLVQQFVCIGMGFGFSVMFAELVPALGVTRSVASLLEAAYFCAVSVGGIFFTSIIRKVGPGRSIILGSTVGSIGIFASGFSPNITGIIILSGVLAGLGMSICFLSGYVAVSWIFQDNASLALAALTIGSSVGQFAFPLLFEVTLAEYTWRGSFMVMAGFPLQCIVCGVVVYGSREYFVTGEQVAAQTNTAEMKGVNHPSRNAYGTLLMDGVVILVLFNFFLLSLTGNCEAWFIVDMLMSRGMTREAGSVAASAIGLANVMGRLAATVTRYKLPNIPTIYHWVYICPLTAITHVLVVNVYQYVSIVGVCIVYGILYGITVAQGPSIMFDVAGLQRYPQGMALINVMYGVGDALSAVLGGYVKDTTGSYGLVFYIAAGASVYTGVSSFICAYFVRKRIVNKPKGAITVKRETRERLISSTMIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7D0</accession>
    <name>A0ABY7F7D0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SF3B6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_032682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR18088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd12241">
        <property type="entry name" value="RRM_SF3B14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034150">
        <property type="entry name" value="SF3B6_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="9"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR18088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="121" mass="13986" checksum="71C339AFFB618612" modified="2025-10-08" version="1" fragment="single">VRLPPEVNRILYIRNLPYKITAEEMYDIFGKYGAIRQIRVGNTPDSKGTAFVVYEDIFDAKNACDHLSGFNVCNRYLVVLYYQSNKAFKKLDSDKKKEELDKMKQKYGLSTPDIHASKPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FC78</accession>
    <name>A0ABY7FC78_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAS35-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="227" mass="24693" checksum="001D5347989CC003" modified="2025-10-08" version="1">MVLLFQAGDGSSVSSLSESCGGCEDTVTEKQYRCKRQVKRPCEQTWSTVEVVPSCVNPYTGCTREKTVFHSRTSECLKSESYCCDGFTKELNQPFCTKDAVSRIDPIISSSITTEEASTTGPQGWNTWSDWSSCSVSCGGCGQQSRNRTCLEGQTCSGANTETQPCGTTPCDTGNTQQTCSSTKTVSISCMFVGTCYKLVTEYYSQPSKCCCGFEVANSLCVVKQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCM5</accession>
    <name>A0ABY7FCM5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_000397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR18559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="104" mass="11995" checksum="ABC18FDEDAE23857" modified="2025-10-08" version="1" fragment="single">MEQTTNDRRHTRYVNYINAFLRNVGKEQAHLVGSTAEDLKLRWSTDGGDADILLVSGRLHIPVENIIPRSDTPRYVWLRGDNINERYRGNLVDGKYLSAQLLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FD64</accession>
    <name>A0ABY7FD64_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011:SF28">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41554" checksum="0D3B4FAFEF8602CD" modified="2025-10-08" version="1">MEREILTGQERPATVVCKEPVELYLPDKGIPELSDFPLELLKTYHFSMAVHNYRRGAVVVKNTNDSEWVYIVRSGSCQVYKAIKDARKERRQMPDSRPASGLPRKKERVGSGLVLPNIHKLKQDVLKCASLADVDEISSKKKKRGQHPGLERSHTLTLPSLSPGNACLVHRKNSFKTPNIATTNIRRGSKELSPRQVKKLTSENIKLSKGHRENTPDILRLSRNDSIMCETPEPVNHTKKVRSQSPSSESMIHIKLKKESVSSGNESVFSHRKQSNASDSDNQKSHSDWSGSDSPRDTIGSTFYVRLGTVMEKGVFGLHQLIYEDMPNLSLVSHGAECVLISKQFLKDHLTKDIANRLRMKLSLIDELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FE09</accession>
    <name>A0ABY7FE09_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_001039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="573" mass="64086" checksum="D64FC0E34617299E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEB6</accession>
    <name>A0ABY7FEB6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="77"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="167" mass="18596" checksum="4833E89EE7F9533E" modified="2025-10-08" version="1" fragment="single">MLNPGTMGVDLQTYRSRIGTFGRSDKQLVVRDVKHTDGGVGGLAKLIGAVSFIGCLLLIAGVEPNPGPGVYPKNKASERDIAILSQYIATNWELLGPFLGVNRTEIGRIQKDNVTTVLRVHALLHSWREVQKDEATLDKVFEALEILEKITRLHPQPKDQPMFQRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FES4</accession>
    <name>A0ABY7FES4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_014647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="254" mass="28453" checksum="0F2C0D6F180B5667" modified="2025-10-08" version="1">MNGYKHSRTDVYMGQGTTLHASQQTDDLSHVMFIFQLFQSGLIFTALMAGAICVGHLVLMRKYCRNTTTLVAVVLSGFFHLIASVRMLTIAENYMKRRVQQGPPSVDSCLDYSMTEAFANGVVLVLIVHNVFVQNFKRSMSSCLAYAGTLGCIITGSFSVIKIVPQNSPLPVTQHSLETLGTYGSQHFTVFLFVCQKNVYEERWAILVEYLVIYLPVMFTVLVALCRNRTKQTGCHYSQSAQPNGFKTTLQFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFG9</accession>
    <name>A0ABY7FFG9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR17996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="102" mass="12276" checksum="D437FA16B256180A" modified="2025-10-08" version="1">MRHITGANLQADREEVWFMSYLFRENMEENVYLRESKPLFDLCEHVFAHFEQEVEKDMDKAEGMMNNDNVTRKLSELIRKLTRKVHKSSQVNYFSLLRTCID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGD5</accession>
    <name>A0ABY7FGD5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UVR8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_000134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="584"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="640"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="692"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="3">
        <location>
            <begin position="719"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="744"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="795"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="863"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="915"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR18296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1229" mass="137329" checksum="759E6CEAD5D50AF6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGW0</accession>
    <name>A0ABY7FGW0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tubulin-folding cofactor E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_002247</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd17044">
        <property type="entry name" value="Ubl_TBCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044079">
        <property type="entry name" value="Ubl_TBCE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="9">
        <location>
            <begin position="42"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR20409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="545" mass="61563" checksum="D837DCD3818875DE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FI85</accession>
    <name>A0ABY7FI85_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_002479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR20641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="91" mass="10423" checksum="0E40B2A6424BC3CB" modified="2025-10-08" version="1">MYDIIVLIEIFLIGFAVEGESVPFCLLFSIEILLKVYTFGPKQYFRDSSNWFDVAITSLALVFLVIGSAYSPKDYILHLRYHRVGIVQGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKS4</accession>
    <name>A0ABY7FKS4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045229338" evidence="1">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="123" mass="11515" checksum="904B38150B6437AB" modified="2025-10-08" version="1">MKVLAILALFGAIVACQAYRKKGYGYGGYRGGYGGGYGGLGGYGGGYGGYGGSWGGYGGYGGGYGGGYGGYGGYGGGYGGYGGGYGGGYGGYGGGYGGGYGGGWGGGYGGGYGGYGGGYGKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLF7</accession>
    <name>A0ABY7FLF7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR23030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="101" mass="11814" checksum="6D3AA674F3900997" modified="2025-10-08" version="1">MKVSHKAMDVYCLLTVQKSMCSLAEERFCFLNTIHSIVIVFKRHFYIFFKKKNVKVMLMPAYFKNATCGFQPKNKPKKKETKSSSKADTQANIHLQLVYIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMS3</accession>
    <name>A0ABY7FMS3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR23355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="90" mass="10333" checksum="CFE0AD843808486C" modified="2025-10-08" version="1">MVEAQVKSGTTVSFDIDEKGKTNTDQNTPDHSSITHFDFIFPVYESGEMQRTETNEVKYDDHTDNYDDYNNYGDKIQGLKETTISPFRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNF0</accession>
    <name>A0ABY7FNF0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">NMD3B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_037404</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="674"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="12">
        <location>
            <begin position="408"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="13">
        <location>
            <begin position="412"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR23735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="880" mass="99128" checksum="E5C7FE04A6CF405F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNH7</accession>
    <name>A0ABY7FNH7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="94" mass="10648" checksum="DE9864D0595C1451" modified="2025-10-08" version="1">MNAAISRGIRGGQIHKVVWKPERHLNIEIYTDASLYQYGGLIDVKGEHIQIAGFRDQTQRGKPIMVLRAVRSKIASHRVDAYIDNKVSFVTRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNK9</accession>
    <name>A0ABY7FNK9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CTNS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_037477</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:66172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:66173"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystinosin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00951">
        <property type="entry name" value="2A43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR23808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="320" mass="36312" checksum="402C3A803D0143E8" modified="2025-10-08" version="1" fragment="single">GSFESKGLLAFTFQIGNGDPELTEGKDNYIKPLPNISLVDGKALNANVSFLGKVFVRIDVVNSKLLVTINAIIGWVYFVAWSISFYPQVYVNFSRKSVVGLNFDFLLYNITGFLAYGFFNDEYKHQHPRGINPVQLNDVIFTLHAIAVTIITIIQCLIYDSGGQKVSKISMVLVIGSWLFAGISLVVTLLHKITWLTYLYYFSYIKLGVTLIKYMPQAYMNFRRKSTDGWSIGNVLLDFTGGSLSLLQMFLLSYNSDDWGSIFGDPTKFGLGFFSILFDILFIIQHYCLYRNNESFDSLIDDIIEEREIMVYSECKAVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FP88</accession>
    <name>A0ABY7FP88_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DMBTL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_037704</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="305"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="426"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="351"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR24035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="531" mass="57298" checksum="275C60AD00EC9D1C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPF7</accession>
    <name>A0ABY7FPF7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR23507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="71" mass="8467" checksum="16C986426FC1AC47" modified="2025-10-08" version="1" fragment="single">ELIDILENFDVNKSTSMLCFPLCMLFSCSINIGVYPEIWKLAHTFDRVWHKGLLLNVQTQRKWNRRENARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FR80</accession>
    <name>A0ABY7FR80_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAR14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_015705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd12547">
        <property type="entry name" value="RRM1_2_PAR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034464">
        <property type="entry name" value="PAR10_RRM1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057044">
        <property type="entry name" value="PARP14_KH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057051">
        <property type="entry name" value="PARP14_RPM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15225">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 35/NMI N-MYC/STAT INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15225:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23084">
        <property type="entry name" value="KH_PARP14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23222">
        <property type="entry name" value="RRM_PARP14_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="338"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="879"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR21731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="947" mass="107700" checksum="41CE9CA781248E1C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRD7</accession>
    <name>A0ABY7FRD7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LIPR1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_037533</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF181">
        <property type="entry name" value="INACTIVE PANCREATIC LIPASE-RELATED PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="5">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR23864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="307" mass="34376" checksum="884C9D29820C70A6" modified="2025-10-08" version="1">MKENLNFEGWLFTSKKKVCYGSLGCFSAAKPFTNAGGQLPRAPDVISTRFFLFTRNNSDIPEELLLNDNIRKCGWKSFCESKDIRIIIHGYMDSIERPWVKKMARTLLKQGDYNVVIVDWRYGAREYNYLQSVANIRVVGAQVAQLLEIFKRLYDTDFGRVHIIGHSLGAHAAGYAGEYVEGIGRITGLDPAGPAFVDEDPEVRLDPMDALFVDAIHTDGEHLFSGDLVQNFACSHLRVLNYFTESITSKCRFTAHLCPNTTRLTSAECSKCGTDMPCGVMGYHTDVNMTSGIYLVSTNAKYPYCQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FS38</accession>
    <name>A0ABY7FS38_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F185A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="Toastrack_DUF4097"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34094">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34094:SF1">
        <property type="entry name" value="PROTEIN FAM185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="222"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="426" mass="46750" checksum="251D057E85359617" modified="2025-10-08" version="1">MNRDEGAFLSGIYNPLFAGLRKFGGKSRVSELRVSDSQASCSDDVHSEVDQIVSFVRVRPGRVHIFPVPYVGKVRAAVIIIHGYYPRSIFKNQLRQEQIESEVPDLGTVLESWYFDVQKHGQLIVSSPMDVHIRPIDPQKYPEMNKLFINVLYMGNDKIRLSELQNLTKQYIVNLDVKEFNTDVSVSCTNTGEACVEQMEGQNVHVKTHKGDCLLKNIKGFNINVETKEGNIVGRKVLQGNLRLTSVDGSITADRVQGQVVECAGRHGNIQVKDVYADKSHFHTHHGNICLGSCHGNTQVTLDIGDLTVGSLDGNLSVKVGRGDSVVAMSREGNINMETGTGDVCVKVAESQKGKVSLTGTSIDPGKVALNNMQIEKADNITSVTGTLANLDSGKKEVKVKTGKGRISLEYYSWLASLNIFKDASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FU91</accession>
    <name>A0ABY7FU91_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="18">PTPRT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MAR_038398</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">MELC-2E11</strain>
            <tissue evidence="18">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00108">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 12" id="KW-0420">Kringle</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="740"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="16">
        <location>
            <begin position="88"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="330"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="520"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="14">
        <location>
            <begin position="844"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="15">
        <location>
            <begin position="944"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="14">
        <location>
            <begin position="1054"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="15">
        <location>
            <begin position="1180"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="108"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WAR24729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1279" mass="144148" checksum="AD29FFC70751FC60" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUX5</accession>
    <name>A0ABY7FUX5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_038200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF8">
        <property type="entry name" value="PROTEIN SLC31A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR24531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="189" mass="21490" checksum="01391C2A7B9657B0" modified="2025-10-08" version="1">MGGTSNENSTMNNLSTEENYKMNPNIQKYFSTENHGDFIFKGLQLNFPAGVVLSMLFVLVLVMLHEGFTYWIQNKWEINRSLKTFRSKNDQQAAESRFHLIATLNKLLTTTLLYLMVLCIVSRNIWILVSAILGKGVGYLLLRPFVSAYINVGFEKTNERRTCIEMRHVNGTVSGNNVELICPLIEASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVP4</accession>
    <name>A0ABY7FVP4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HBS1L-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_036915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037189">
        <property type="entry name" value="HBS1-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109732">
        <property type="entry name" value="HBS1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="496"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="424"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="424"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR23246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="909" mass="99396" checksum="F0708B6A6D85F9AA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWF0</accession>
    <name>A0ABY7FWF0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="13"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="178" mass="20325" checksum="7C1BB832A39117C0" modified="2025-10-08" version="1" fragment="single">MKTYLGKTFDPLQAGRLGTAVVKSLMSVCHFLHRGYHVVVGSFNCSLDLAKQLMQRYTYVTIYLDFFPKQSFINKSLDRCAYYLYARLSKCIACTCSYIKTLRSNRPMPKIYMPSRALYSWPHSETTTDRSRLLTTAVTTRDDGNGKPAVVRHYNTHMGGVDQGDMLMSFYNAGQKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWL6</accession>
    <name>A0ABY7FWL6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF291">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="219"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="276"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR26027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="326" mass="36989" checksum="FD3E88D16DA259E8" modified="2025-10-08" version="1">MVTTVRHPENEVTIREKEPCVCPTKQAGCSTFAAQNSLRPNPVTPSTNKSISSTDGVGKDSIQRLFNDIANAMRKSQRNIRYEVHKDVNALYGSISNQLLKNRGEYENESEGYAEGSNFGSSDDENINRKLWHIWIKNYASILQHLDRNVRDMRYKFSIQTHLRCSRSSFRSAALLWNTGLRVEMVRLQADSSINHEQTMASNFESIQMGCDFIHDFACSACEEDGLNTEAQHFCNQCTKYYCDNCVPVHNKLYKRHAVLDRKNVKKWAAAPGTVDVLERCERHPGEALKLVCGDHDQLCCHMCVAVDHRLILPHTVVAGPLFQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZ87</accession>
    <name>A0ABY7FZ87_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GPKOW-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_012661</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd13153">
        <property type="entry name" value="KOW_GPKOW_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041994">
        <property type="entry name" value="GPKOW_KOW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25088">
        <property type="entry name" value="GPKOW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="G-patch" evidence="5">
        <location>
            <begin position="143"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="239"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR26957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="424" mass="48272" checksum="EDBD37C62DC07F1F" modified="2025-10-08" version="1">MTEPEKVSVSFGFSKKSEKKVLKRTINDEEKKYLEETDYVTSLEDKEVKSSKPKQEKKEIVIPLIKTNNWKTNHLKAANNGLDSQAASARQESWETRGAVDTDLAIPLLMQNQVPEGFETDDRLDVSLRPDEPEDAVYEDVPIEAFGMAMLKGMGWKEGEGIGKNNKAIKPVEAVLRPKGMGLGADRGQAQDLNKSKQGSVGKQEDSLELRLKKGAHCLIENGVNKDLYGVEKEEREEQKYAESKHGDKRGREWERSGSRERARDKHGRKKDKRKDREHDEKPESSSSYTNGSGSSQRAPPLWLKPNLRVRLVDEHFKKGKYFNTKLVIVDVMDRDHCVCKTEEGKILEDISQTMLETVVPRSDSSYVSIISGKHRGQLAHVLERDKRKYLATLQLLSDRDTVLQLDYDSICEYVGDINEEYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G162</accession>
    <name>A0ABY7G162_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="730" mass="81399" checksum="606A09E12B20407B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G175</accession>
    <name>A0ABY7G175_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="386" mass="41046" checksum="30A75347D0D28C67" modified="2025-10-08" version="1" fragment="single">MGGAMTTITPEEVTNVPVEENVARVTFQLDEPTPIVKVQVTPDESVSTIRVTVTTPGGDKFTITLRETEGNVFVGDLPEGTLVSKVEVEQTLKEDTEGPIKSGIVEFQSCTPSVTTTTPTPTTTPNEICPMGGAMTTITPEEVTNVPVEENVATVTFELDEPTPIVKVQVTPDESVSTIRVTVTTPGGDKFTITLRETEGNVFVGDLPEGTLVSKVEVEQTLKEDTEGPIKSGIVEFQSCTPSVTTTTPTPTTTPNEICPMGGAMTTITPEEVTNVPVEENVATVTFELDEPTPIVKVQVTPDESVSTIRVTVTTPGGDKFTITLRETEGNVFVGDLPEGTLVSKVEVEQTLKEDTEGPIKSGLVEFQSCTPSVTTTTPTPTTTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1G5</accession>
    <name>A0ABY7G1G5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="78" mass="9106" checksum="F62AFC3B7DC69797" modified="2025-10-08" version="1" fragment="single">MTVVGSWIHYVCMPFEFCDMIMHCEISSDCCFNVSKHSIMLYEHKRSTYSTGLNWKTVNDANTKLDQTMPLNDDEFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1X2</accession>
    <name>A0ABY7G1X2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR27098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="88" mass="9801" checksum="CC3D59FD0BA2153E" modified="2025-10-08" version="1">MFLHVSQFAKNHDHFSLTLSPEERCNRLEVCSPTPRNVKPSTIAVSVRHQRFSGFSSNTLMNAPVLSFSITKPNSVTISRTSNVEAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4L3</accession>
    <name>A0ABY7G4L3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C163A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_002958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="5">
        <location>
            <begin position="254"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR29390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="372" mass="42371" checksum="170819CD2B00DCF0" modified="2025-10-08" version="1" fragment="single">MVSVSSLQRNLTFLDKQIVSFCTRNMILAVQLVPSIIATMSTPLCFLMFGLIAMRPVEGTRLDRLEEELKALKGFIFKELGYIRDDVKEIAYRVDILENTTVTHDPSSPYQDIGITSYNLDEKNGDSGKLLVRDGNNEGSHVVIAEVQNMRKAYANDKKDLHQLKQDVKGQLRDIELKITSHMHNLTADVQQNIDLVSVIRTNFSEVPTQITNLSLQLKLTEKEIKDAEERLRICIHTKVSIQDGYYFPCAKDIRLANASPYRSTGVQGRLEVRHDNTWGTVCDNSFELGQVRKQDIENNVNVVCRMFGFQECKYVRWARLGRGSGYIWMDRVKCGGRESSFLECPHLGWGVHICSLYEDIGFLLRIVGQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5F0</accession>
    <name>A0ABY7G5F0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">IIGP5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_002953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051515">
        <property type="entry name" value="IRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341:SF10">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRG-type G" evidence="6">
        <location>
            <begin position="113"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR29385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="194" mass="21183" checksum="9C858FB19B3DCB56" modified="2025-10-08" version="1">MDSADQSDPINRKDSHKGQQQRLPCDNDSKEGASSRLQSEDQQVSALNESIAALLQDIPSDEVPGRRQPGPLHFEIGGIAKVKMDYYITLLINNSDEEMQQQVDNDLSSWKNVQIEIAIAGESGSGKSSFINAVLGLTADDEGAAAVGCTETTMEVTKYVHPETQNIAFYDLPGIGTPKFPKDNYIELVNLDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5U0</accession>
    <name>A0ABY7G5U0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_014242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047351769" evidence="1">
        <location>
            <begin position="19"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="180" mass="19544" checksum="E825AD3D7EB83DA7" modified="2025-10-08" version="1">MKFLQCIVFLCIWTAGEAEFDATCTTSNGQCVTRCTCNEGYTDMDEQCFAKVGRSCATNTDCVPDASCTGSTGSQTCQCPNSLVPSFYDTKCKFKVGAECKDSSDCMIHSECRTGTCACMDKYAPSSDNKTCIGYVGAECDDISQCIEHAECSGGKCTDDYEGDINCQKKGMDYVQHRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7T4</accession>
    <name>A0ABY7G7T4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNJA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_003177</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="126"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR29609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="380" mass="42369" checksum="0E5D2E830C348323" modified="2025-10-08" version="1">MVKETAYYDELGVKPSSTPEEIKKAYRKLALKFHPDKHPEDPEKFKHISQAYEVLSDPKKRETYDRGGEEAIKGGGGGGGGGFDFHSPMDIFDMFFGGGRGRQRGPEKGKDVIHPLKVSLEDLYNGATRKLSLKKKVICSKCEGRGGKEGAVEKCPTCKGQGIQVHIRQLGPGMVQQMQSVCTECGGKRERINPKLRCKTCLGKKTIEDHKILEVHVDKGMKDGENIRFTGEGDQEPGLEAGDIIIVLDEKEHSRFKRNGSDLIMDMELQLVEALCGFHRTIETLDKRSLVIFPKSGTIPADKIPQLEKCFPPRSEIIVPDGAEEHSLVDFDPEEQRRRGRHGEAYHSDEEEGPGGQRWDEESVEASPAGTSTWEEGQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8S7</accession>
    <name>A0ABY7G8S7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DZIP3-like HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="28166" checksum="8CBBD14EAA473B2D" modified="2025-10-08" version="1">MATASICPASFGQEEINYTKMQMIIQKVCHKVLVEYLLKYIKDKHPGDSVDVFLSNNENTVNGGRDSYLYEKRYFPKDTNKQPVSTNVHKWDIQMLYFVLTRCCNLKHLEMDLTFIKDKRNYLCHLGEPKVPDGKFTSFKQDIDPILGRSFKCFGDKFEKEITEDMAIIDSHLTEQLIDAYQALHREHFVAEQIKCLCEEYKRTSAKHTDYFMQLVCGQTKIHDLFFAFAKTTLAPPAFFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G920</accession>
    <name>A0ABY7G920_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SREC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="294" mass="30519" checksum="449BFCCF3E9BC6D7" modified="2025-10-08" version="1" fragment="single">MTCARDGTCSGGCKAGYYGAECDRQCDACLSKECEASSGVCSIGCIPGYYGNMCQTRCPTNCVECERTSGDCTSCISTFYGLPRCDIVCNANCLPGLGRQCDQSTGKCVHGCHGGFYGDDCQESCGQCASGVCGTNGACNGCNVGYYGSKCTLTCSDNCESAASGRPCAQTNGFCSNGCRPGYFGDACSVQCPARLDPQAFIALTTSNLHFVNKILRCSPAFCVRSTGDCGTCQEGYYGPKCDNACNNCFESRCSSVNGDCTSGCTVGKYGSKCNSDCKSTCNDGSCDQTSGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9R3</accession>
    <name>A0ABY7G9R3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HMCN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF21">
        <property type="entry name" value="SEMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR30284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="237" mass="25347" checksum="96DCE06ABCCA336F" modified="2025-10-08" version="1">MLHPVTGAWGEWGSWMACSISCGTGYSARYRICDSSAPLFDGNDCFGSARSYKQCNIGPCPINGAWSEWSVWGTCSQTCDTGVKQRGRTCANPSPAHGGQACVGNSTDAAPCMIQETCKVDGNWTLWSYWSTCSVSCGIGITTRHRACSNPSPTFGGKYCVGSNSESSNCTEASEGCPVDGRWTLWSFWTQCSVTCGTGIQTRHRACANPSPTFGGQNCKGTNHQTTSCTEPICRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GA30</accession>
    <name>A0ABY7GA30_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HMCN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_033812</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047430455" evidence="7">
        <location>
            <begin position="20"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1048"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="6"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="113"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="207"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="337"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="469"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="560"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="655"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="742"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="824"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1177"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1313"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1326"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1355"/>
            <end position="1364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR31270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1500" mass="163262" checksum="A48E1D17EE79FF47" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DB40</accession>
    <name>A0ABY7DB40_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_006401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF3">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ93930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="52814" checksum="33769F0E44403B16" modified="2025-10-08" version="1" fragment="single">MASNKEVGDPCQFDKLSVRELKMYLRDRGAHVSGNRPELIKRARGLVQIGKRTLKEINIQDNNNKLERQEELFTTPLGEKLPEPGSLKGCWEDDVLKIPFFRTQDLYNYLVLNRSRTFDNQNMNARKQLKAKVFYEDGHVHSVKYNQISHKCSHCYVRAKVIPSLPGSDVQKKDYEPWACLSKVSGKVHAAGCNCAAGEGESCNHVAALLYALVDIGSKQKDGLNAPTSTKCKWNQPRKRKISPQRSQHLVFKKLKFENDTLQKVSPSIKCKVDNLHNVKPLNSLAFGEKLKKCAPHAAFLLSDSELVAPEEPIPVLHKLHSVDFFYKDSVDLKSSMCENNFETYFKSLNCKQDDCFLIENSTKGQHKSYHWKNARAGRLTSSSFGTICKKKPETKPDILLRSIMGYNDEFDTAATRWGRSHEPAAKRVYQRRIQITHPGLKLFSSGLVVKPSLPHLGSSPDGIVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DB89</accession>
    <name>A0ABY7DB89_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LUCI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_007019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="51"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="180"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="402"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ94548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="497" mass="55536" checksum="D3553EB986E8DDE5" modified="2025-10-08" version="1">MSLTPFAAVIRLVSSYICTISHVFAVMSEKPPLRLEDIPVTYMTAYLLDKIRHYGDKVAMVDATTEKTTTYSELVTRIERAASGLQAIGVMKDDDIGVLSPNHPDYLVTFYACALTTWPKFSETATPSSCLPCLLFCPKYRKRHREAGGDYETFESLLDPGHAPYRTPELDPRTCAGLNSDKDTFVTFFPFFHALGLYMVCFVGHCLGARIVIMPRFDFETFLRLIEKYRPRNLQLVPPIMVLLAKSPKVSEYDLSSVSQIACGAAPLSKEIEDLVKEKLKLPCIFQGYGMTEVGVTHLNGRGELRYKSVGKLLPLTEMKIVDVETGKRVGPGQEGEIWIRGPQVCGGYLGLPEQTRELFTNDGWVKTGDIGYEDEDGYLFVVDRLKELIKYKAFQVAPATLEDILLRHDAIADVGVVGMPDVEAGELPRAYVVRKQGREASEEEIRKFVDDQVAPHMKLRGGVEFIQEIPRTASGKILRKSLRELARALAAKRPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DD46</accession>
    <name>A0ABY7DD46_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_007153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF25">
        <property type="entry name" value="PROTEIN LIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ94682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="591" mass="66230" checksum="54FA07F168B19091" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DD57</accession>
    <name>A0ABY7DD57_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_028277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ95587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="111" mass="13224" checksum="7EE54318F9875E6D" modified="2025-10-08" version="1">MPHMLQISSIQLKFSVTKLRDEEFDGILRRVDRLGSKIRSDRRAKIRTRHSRSTVDKCHRHQHHANDRLTLYMKRIKNYFRSTMSTDRISSLALLHIHKDKDINNVINTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDT1</accession>
    <name>A0ABY7DDT1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_007378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF26">
        <property type="entry name" value="PEPTIDASE M28 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M28" evidence="3">
        <location>
            <begin position="34"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="3">
        <location>
            <begin position="199"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ94907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="278" mass="31483" checksum="A72EC5C9781AE2D5" modified="2025-10-08" version="1" fragment="single">QAILGADLEYIRSTLTQHFSDTRHHIANPAYKRVDDNGSGVTAMLESLRQIAAGNKGGKRRKNTIIFMAFDHEEYGLIGSKFAIEQWLLPWLTQNYGQQVESLKPNGIIILDTVMNYNSSAKSQIIPPEAVKTDYFPETVSSIASDNFQGDFLATIFRQNLDGFLASTFNSEWLGEPQPEFEIEKFGFPYQDVNEDTWNVFANLFRSDHVNFWETNIPAIFITDSADFRGQMQQCYHNACDNLANILTDNNVRFLGKTADTIAATLNKLSEAYNQRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DEJ0</accession>
    <name>A0ABY7DEJ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_028038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ95348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="13180" checksum="CF1D93BF23884264" modified="2025-10-08" version="1" fragment="single">IQHKIAYCTNSNNPAKCNCGLAVRAGRDVYVINVCNGYIDIGYKQCWDKALTVKKENDFTYTPESTTLLLWAKREEGFWIFQSFPQCKTDKEIVQDCVVPLMTTVLMTLTMKRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DG72</accession>
    <name>A0ABY7DG72_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="201" mass="22695" checksum="2DF870B670B1528A" modified="2025-10-08" version="1">MFLSPSQILYTHQYDPEIRMSTEQTFSELMKNSIHGSVFPKLQVVKKDGYYFTLNDAKLQVYRHLEKLGKCGSVEVDRVALKEVPEGIRQLMKAPEKVKRRRNVMSKTKDGGKYTSVSSSSAIDIPDEDLLVLASCDDASDGDEKNSSEESSDIEDTDSDSSDWSDEDVSDTDIQTDEDERSRLQPQDYSAANNDENESFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DI67</accession>
    <name>A0ABY7DI67_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_030017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016729">
        <property type="entry name" value="FADD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15077">
        <property type="entry name" value="FAS-ASSOCIATING DEATH DOMAIN-CONTAINING PROTEIN FADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="250"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ97327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="36805" checksum="92DCD163E860BC2F" modified="2025-10-08" version="1">MGQYASIFITPANKAVSKNTHPRKPNWITAHAIASELSIAEVERLWVRFQQLGCNPDGELTDSTIMKADYSQDVFMKNILKKYMEGNTKKVTFENFLRALKWVEQSTIDEKIRAMYHFLGNGQPLTPDLMVKILERVYPQDKGEPIKKIVEILFQVMDTDGKKALDEEKFLRGVRKIPPQVLDQYLTFQILPDEMKERLHKNLQEFRSESQIAGPSNAPQNRTPMNARRAKQVVPDQACREVSEKIFKKDWLRVANKLGFFTQDVQEIQSAYPNNAQHQVYQMLKQWKERDGDEATLEVLEKALADCGMHDAAIILTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIL9</accession>
    <name>A0ABY7DIL9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">INVO-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_029245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052949">
        <property type="entry name" value="PA_immunity-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42999:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42999">
        <property type="entry name" value="ANTIBIOTIC RESISTANCE PROTEIN MCBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ96555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="542" mass="60113" checksum="9DED1F86C5952B16" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKT0</accession>
    <name>A0ABY7DKT0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_022695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd10229">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="910"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ98322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="929" mass="105248" checksum="FD6483E4D7F32D96" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPE0</accession>
    <name>A0ABY7DPE0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TOR2X-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_022321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF2">
        <property type="entry name" value="LD13476P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="TORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06309">
        <property type="entry name" value="Torsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ97948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="183" mass="21008" checksum="FA96325454D0EBA7" modified="2025-10-08" version="1">MSNQYVHYFSATKDFIHEGKLEENQQHIVATVQACPESLFIFDEMDKMPSGIMDVVKPFLEYNQPVEGTDYRSSIFLFLRGPMKINPKRPLVRSFYGMPGTVLNFVSSLITEHIYAKGMSSHYVLYFSATKDFIHEDKLRENQTPGRTAIWLGAVLFLRISHFNSGKKTAETCIRDVDNDVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQ27</accession>
    <name>A0ABY7DQ27_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Beta-N-acetylhexosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-beta-glucosaminidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_023384</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004866">
        <property type="entry name" value="CHB/HEX_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004867">
        <property type="entry name" value="CHB_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF57">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03173">
        <property type="entry name" value="CHB_HEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03174">
        <property type="entry name" value="CHB_HEX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SMART" id="SM01081">
        <property type="entry name" value="CHB_HEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="Carbohydrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045268539" description="beta-N-acetylhexosaminidase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="Chitobiase/beta-hexosaminidases N-terminal" evidence="9">
        <location>
            <begin position="29"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAQ99011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="857" mass="97639" checksum="231BA52C64D23108" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQE3</accession>
    <name>A0ABY7DQE3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ98895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="72" mass="8449" checksum="558CB78C9FA03241" modified="2025-10-08" version="1">MLPEDGDSCIDIIEREKAFTLVLVMITVERDQTKSSENRIYKTEDTHFFSCLYCVLIRSGFPLTLWIQTHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQM6</accession>
    <name>A0ABY7DQM6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="304" mass="34503" checksum="3B8E8F091D4E79FE" modified="2025-10-08" version="1">MSVAMDIEKEVVDFLLMEKADAQKVQNMCSQSVHHLTPIPEPIQNLRVTIKHSGIRRLYKRGPVITVILLQKTEVKGPRSSYSVNTSRSNLFKLEFFDLNLSTVRLYFKVLFVVPLNISLELDIIIVIVSDTDTLPILPAVTQQFTMIVYNYSQLDFALITEVQSPGAGIYSIPIVNSHAYRQKSVSTVHVNPSTCDDHRFIILVKTARSKHKVKNKSRTTVTARCALFDLQQPQRLVNQDLMQNFCCMLDCVLAMAVRPDTYRISQLTTPDMGRNNSRDIVELLIDGWNCVDELLDSAECKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DR11</accession>
    <name>A0ABY7DR11_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SREC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_023143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ98770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="207" mass="22684" checksum="5D0025A88C783AF4" modified="2025-10-08" version="1">METNNGTQVNSPDETTVGLHVRLDPPRIAQYINIKKEDTNDVMTICEIESQCDVLTGNCNECEPGWYPPTCETACSQGYYGQDCSKECSHNCVDNNCNSQNGSCVHGCKPGYDYTMSTNCLVDEKGERRFTASEVAGVAGGSVGSCLLFLGLVFASVLGYRRYKSASSKTDSTNVISDVENTNTGRAYEGPYEMSLKNNDEHIYQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DR78</accession>
    <name>A0ABY7DR78_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FEH1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_023452</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd01272">
        <property type="entry name" value="PTB1_Fe65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01271">
        <property type="entry name" value="PTB2_Fe65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039576">
        <property type="entry name" value="APBB1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058">
        <property type="entry name" value="AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058:SF8">
        <property type="entry name" value="PROTEIN FE65 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046919583" evidence="3">
        <location>
            <begin position="22"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="4">
        <location>
            <begin position="532"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ99079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="954" mass="107045" checksum="00AA696689A6DB2C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRI6</accession>
    <name>A0ABY7DRI6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl-coenzyme A reductase</fullName>
            <ecNumber evidence="4">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_024694</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15991"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="4"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SSD" evidence="13">
        <location>
            <begin position="104"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR00322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="809" mass="87113" checksum="C1D0C9453A46DBFF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRM3</accession>
    <name>A0ABY7DRM3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="132" mass="14602" checksum="D6CBC1B78B11B140" modified="2025-10-08" version="1">MAPIFLGRKRGSLQRGVRPPLCPPPSISVPPKIMRTVTSRTVPDPASGIHSETGLRWNNEHQFREVGADCVLQERGVREATYHADGLYAGINGVVQQLLNLLHHSVNGHLEETLGYLMVHSQFVPHKLNLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DT03</accession>
    <name>A0ABY7DT03_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_025225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="108"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="315"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR00853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="408" mass="46169" checksum="DE6363A1D589AB4F" modified="2025-10-08" version="1">MGVTRGLLYAAVLVVFLGLYARPRFPEPANNVWLKTIVGLHIQLIHYVSVGGGLVGLSPINITRTMTDVSLLLNRPAWDVQEERTTMDGVEVIIFRSVDAGEGRHPGIIHIHGGGWALLSPDHYGPVCRELARETKAVVISINYRLAPEHLFPVPLEDCLKVTKYFLRNAEQYDVDPGRVGLKGDSAGGNLAMAVALNLSRDGQLPSLRALSLDYPAIQMFTFDLPSYHKYEVGPGFLTKTIMINYWLTYIYGHRKYFNIVYNRDHIDEQTVAKHRDNFATDLLPPFIRDENVTSSFKMRDDYKQDKEQIQREITAKILNPMLAPLMSSDEDLATLPPTHVLTTEFDALRDEGFLLVERMRRAGVSVSHSYLPAEEHGFLNFVDIDVNAEREMEKTAQFFIKCFETQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DT46</accession>
    <name>A0ABY7DT46_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="117" mass="13095" checksum="1B1D1C95B6139686" modified="2025-10-08" version="1">MIKGVVHMDARGAGNVAEDAAADLARRREAAMSAYYVNRRFVFIKHSVNLITALMNGVNLFSVLLPFLCGKVRVLVCYSDQRSRIDDINHEGDLKVKDNESVVIVNIIGNFHNLMFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DT91</accession>
    <name>A0ABY7DT91_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ITSN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_025290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026:SF1">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="161"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="246"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="478"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1056"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="714"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="730"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="741"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="783"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="829"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="879"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1058"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR00918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1265" mass="139458" checksum="1738C525C4D356EF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUE0</accession>
    <name>A0ABY7DUE0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CADN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_007881</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF442">
        <property type="entry name" value="PROTOCADHERIN-15 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="22"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="176"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="308"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="406"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="516"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR01323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="620" mass="68385" checksum="619DE91423ED887C" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVA8</accession>
    <name>A0ABY7DVA8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SMN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_024993</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">Z line</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Cajal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
            <location evidence="8">Gem</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20398">
        <property type="entry name" value="Tudor_SMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040424">
        <property type="entry name" value="Smn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049481">
        <property type="entry name" value="SMN_G2-BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010304">
        <property type="entry name" value="SMN_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047298">
        <property type="entry name" value="Tudor_SMN_eumet"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267:SF1">
        <property type="entry name" value="SURVIVAL MOTOR NEURON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267">
        <property type="entry name" value="SURVIVAL MOTOR NEURON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20636">
        <property type="entry name" value="SMN_G2-BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06003">
        <property type="entry name" value="SMN_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20635">
        <property type="entry name" value="SMN_YG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="10">
        <location>
            <begin position="77"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="137"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR00621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="275" mass="30164" checksum="F20F45ACE86AB340" modified="2025-10-08" version="1">MAEPAPGEFLFHRGQEEEEEDIWDDTALIKAYDEAVSLVKMKVAEQNGEVTPEVGATAGGKTKKKKNKKKQRQQNKPLTIGSLCRARYTEDGCNYDAEIISIDNDAGTCVVRYLNYGNEEEQELAKLAPLKTKTQKLLQQRLDQSETDSGVDGRSEKSSSRQPPSHTGSMNPPQAPFTPPWGAPPLTHTGPSQMGFMPPMFSGGSGFGGPWSASQTAPMMPPPPPPPLADMEETENEALASMLMSWYMSGYHTGYYQGLQQGKKSVGYSSHFVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVD1</accession>
    <name>A0ABY7DVD1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="210" mass="24261" checksum="8704EF2E4837226D" modified="2025-10-08" version="1">MIGMYRSRIAYDQNSDGSVNILFIRSKGKKLKRWISFQNQTNFTKFCIYTCALIVTGLLCLMLGNGFIRTLVNSFEIMDINESGSEHRGEISQWPNMPNLGLKDDDVLKAAADNTQKETVSIIYTEKPNAFREARHENTYGHSENGIPKGFKEQLKEKRNEYDNKGLPAFFLEEQKEATTEYLDPMGTCAPTTFRPQEWWHKLFAIKKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWM9</accession>
    <name>A0ABY7DWM9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RIMB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_008691</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RIMBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12014">
        <property type="entry name" value="SH3_RIM-BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12013">
        <property type="entry name" value="SH3_RIM-BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057884">
        <property type="entry name" value="FN3_RIM-BP1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035755">
        <property type="entry name" value="RIM-BP_SH3_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040325">
        <property type="entry name" value="RIMBP1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14234">
        <property type="entry name" value="RIM BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14234:SF19">
        <property type="entry name" value="RIM-BINDING PROTEIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25523">
        <property type="entry name" value="Ig_RIMBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="236"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="388"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="957"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="653"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1038"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="653"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="678"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="702"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="790"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="823"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1049"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR02133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1084" mass="119337" checksum="9CE87D1CD95C5871" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWY5</accession>
    <name>A0ABY7DWY5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">OAR2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_007967</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002002">
        <property type="entry name" value="Octopmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF174">
        <property type="entry name" value="TYRAMINE_OCTOPAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00664">
        <property type="entry name" value="OCTOPAMINER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="37"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="219"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR01409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="433" mass="49076" checksum="8880C6D6E52F1F68" modified="2025-10-08" version="1">MENNTSYSVLLPERVSSWYIVLTSLAMIILAILTVAGNIFVIHAVFTNRALRIVPNFFIVSLAVADLLVAILVMPFHISTNITGAWIYGGVLCQIWLTSDVFLCTASILNLCIIALDRYWAIHDPIRYAQKRTVKRVLVMIAISWTLSGMISIPPVFGWGDKDDDSLYDDDVKTCTLSSDKGYVLYSACGSFYIPLAVMSFVYIHIFIATKRRLRERTKAAKKTKLAMRNIVNNKDGNANKKRNNSDSTNDDHDERNEDIVEEPSNHCNTTSSESANNVCNGSANVALTTTDKKKRKKTRGKRQIDSAKMEFEDNARHLRPRVSINNFFEEKQRISLSKERKAARTLAIIMVTFVLCWIPFFLMYLILPFCDSCTYPGTKVEALFVWLGYVNSTLNPIIYTVFNMEFRKAFQRITAKCRGNDSGRIALTRTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXZ7</accession>
    <name>A0ABY7DXZ7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="77" mass="7790" checksum="48A97AE90D7BF737" modified="2025-10-08" version="1">MAQPKSKKFKSLFDFGFQQRTGTDDCHGSAGASDEPGVSKPESSGNSSTTNAVGSGDNAGSSSRSSEPADNMSKGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DY89</accession>
    <name>A0ABY7DY89_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWDE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_008315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045701180" evidence="2">
        <location>
            <begin position="21"/>
            <end position="2595"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="3">
        <location>
            <begin position="2028"/>
            <end position="2206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2270"/>
            <end position="2292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR01757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2595" mass="289842" checksum="CFEBD13010691308" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0E8</accession>
    <name>A0ABY7E0E8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UN93A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_008968</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF13">
        <property type="entry name" value="PROTEIN UNC-93 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR02410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="270" mass="29813" checksum="6693100BB4D08B39" modified="2025-10-08" version="1">MTSQDAFLDKHGGKERRNVFVLSASFTAIFTAYLAIQNLQSSLNQADGLGIISLSCMYACIILSGILAPSIIGFLGEKTVIVVSFICHVVYTCTNFYPTFATLIPSSVLLGLTAGPMWTSQSVYLSDMAYSYAGRKNSDSHTILSKYNGIFFAMYETTQITGNLISSIVLQQGTYNYTNTNETVKFCGRYGCPKEVNALIALLFADKKDAAFANYHTWKAIGFTVTFVYSNFLCVSTKLVVAIGLLVAAMLLYAIVEFRVRSRNERTYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2V9</accession>
    <name>A0ABY7E2V9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_009690</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF166">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="216"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR03132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="250" mass="29693" checksum="5E8FB0ACA15DAB12" modified="2025-10-08" version="1">MPSIWPTVIIVSMYLIVIIGGQRVMRNREPFQLNNAMMIYNFCLVVLNAYIFYEGSELADRLARNCWFFFFSKSIELMDTVFFMLRKKNTQITFLHLYHHSTMPLIWYIGVKYAPGGESYFSASINSGIHVLMYTYYLLAAMGPSMQKFLWWKRYMTVMQLMQFWGILFHTSYAIYTDCGYPNMYNWALIFYDFSHIALFSNFYYQTYTKKARAARAKREESNGRHDKQEEVSNGVHAKNGNTRLRSRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2W6</accession>
    <name>A0ABY7E2W6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SRPRA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_019726</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Signal recognition particle SRP54 helical bundle" evidence="11">
        <location>
            <begin position="298"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="403"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="10">
        <location>
            <begin position="404"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="128"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR04357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="595" mass="66388" checksum="B202C25EC5CA0BCB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3B1</accession>
    <name>A0ABY7E3B1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (32-2'-O)-methyltransferase regulator THADA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_009855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF7">
        <property type="entry name" value="THYROID ADENOMA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="6">
        <location>
            <begin position="363"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="6">
        <location>
            <begin position="501"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="5">
        <location>
            <begin position="737"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="7">
        <location>
            <begin position="1012"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="444"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR03297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1121" mass="125186" checksum="2B4B91C6CF8952B5" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3Q4</accession>
    <name>A0ABY7E3Q4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Battenin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_010407</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Lysosome membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF7">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR03849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="422" mass="46460" checksum="DA06F62214C6CC1F" modified="2025-10-08" version="1">MSIRLKHVVCHVSTDLALTGRPDYRETKECYPTVPSCSTRMIGLFLLGTINNLPYVIVTSAASTIADSFGKKNLIGLVFGANVALSAVVKAINGAFLLNVSYGIRYAVNACLMLIASAAFGENVALGYLRFFPSKMVNAWSSGTGMAGVLGSFIYITFGCVVGAGGDNLGKLRHLTQYAFLLTSPAVVVYLFSYFLLIRRPVERHEREPDHIQQDSEREPFLGGEGQEGPPRIEDVSSSLAQLLDAKPPPETSLQRIWRCFKLVSWVSINLCAVYLFEYVAQGCAAKVRPKKEYNIGCPELYAGLSLCYQAGVFVSRSSVQMFQIRRVHILSILQFLNMLLWLIDVHYKFLPVAILPALMVYVGLLGGASYVNIFYLLLHDKAYPDTDRELCINIAALFITLECCQLFASVPKCDAVTTAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5V0</accession>
    <name>A0ABY7E5V0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SVEP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_019684</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050350">
        <property type="entry name" value="Compl-Cell_Adhes-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325">
        <property type="entry name" value="COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325:SF575">
        <property type="entry name" value="LOCOMOTION-RELATED PROTEIN HIKARU GENKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="50"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="111"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR04315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="171" mass="18331" checksum="6D358558D879777A" modified="2025-10-08" version="1" fragment="single">RGTTTYTEGSGYGSVASFACDIGYRLEGAAVALCGETGQWNESSPVCRVVDCRRLESPDNVMVTYPSGLTIYLSEARLSCFPGFDLQGPSIALCTETGKWNITTTPFCDIKNCGSLEPPVNGSVRLTTGTTYLSRAIYFCDTGFNVTGALSRRCGNTGSWEPQNPTTCTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6M9</accession>
    <name>A0ABY7E6M9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="198" mass="23092" checksum="49A4B4A829E6EAE9" modified="2025-10-08" version="1">MEFTKRLRLNFLRLESEIIQRRKTKGGPLGVWFRTHSWLRYSPAERNDDEVWNSLFQKAVDIAGDVDVVLAVPDVMVVNKIDRMPQALWKGNILFPFVDHLLVELETRLIQGHGRFCAQKLIPFKIQNDGLPWESIADVYQAFYACLDTDETIFVRECKKWRMWWTDRTLVVDRPAAPVSLAESITLASKALYPSIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6U8</accession>
    <name>A0ABY7E6U8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="50" mass="5633" checksum="E5E977C6FBDCF7D0" modified="2025-10-08" version="1">MFYSFTCTNYSFVNGGSIKVILDPPQIADLNTTIEVLEVKTLKEIHLINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EB61</accession>
    <name>A0ABY7EB61_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_017201</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034720">
        <property type="entry name" value="Viral_alk_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01771">
        <property type="entry name" value="Viral_alk_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR07243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="33925" checksum="A4957CE6515D0A43" modified="2025-10-08" version="1">MRRNTFHKPKKQYSGTPLKAEDLPGNKQTNKFQDPRPPAFRNCANYRDHVRNTVFNYCSNTSKDLAFRYIWGKADIQSAGRKNDYLRRPLLEQWVDNAQHISPEQIVAIDRRTRSQADNHTWREQCLWRVTASRFGEICKLTATKNMNKVCKSVMTSSNLHSKPIIHGKQCEETAPFTPDGVISDTTIREIKCPYSGRDMFIKPGKLFPFLEYDSQGNIVLRQTSNYYYQIQGQLYISKIKYCNFIVYTFKGIMFQKVELDNDYCEGSLIPKLTLFYEKYLRQYIAVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EB70</accession>
    <name>A0ABY7EB70_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_021495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027197">
        <property type="entry name" value="SLC43A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20765:SF1">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOBASE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20765">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 43 MEMBER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR06126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="252" mass="28444" checksum="193F25888318D369" modified="2025-10-08" version="1">MKLRLSPNQAKISYLFPAVQSTITSVFVGFYDVSTVFTYLLKVCYESGISRGYYCLGLALVHLILVGISTCFLLPSNKLKPRSTDHANARKENPSAATYDKVPGPDGNCISEKEKFLKVKTQDHTADGRKVRALHSLCSIEYLLHVFWMCCHGLRFVTFLGFFSTWMGTKFGVNSIKENYYLGVFSYVTMGTAITAVTAGMLHDCQRRQYASTRYKHFPCYSEFCIPRPGWLVYSSTLYLSGTSRTSLLRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EB80</accession>
    <name>A0ABY7EB80_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_021043</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="173"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR05674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="340" mass="37606" checksum="889CD789A523E9B5" modified="2025-10-08" version="1" fragment="single">SDPPRITNLNAFVKVLEGVHFSFTCEAEPGNSKETSYFWTSQQLPGINIFGQYLIIQNISRADDGIYTCFARNVMQPSGCMEINGSDVKNITIDVQYKASIITFTAMNTTTTTTVHHGDEVRFACEVDSDPPADIRILSTNGSILKNINDNYLLSYTKNSSCLEDIGSPLYRPNYFQNSTFKTRPGTKIKLHFSVFSNPPPTQFIWTNISNSMQLPNDTTSDRVIINTSDDMSSSLIITSAEPWDSGNYSVRVENEIGSMVETFHIIVDSNPEPDGETYTSPTSDNGTGSVVGGIVGAVSFVVAVAILIAIFFYKKRQCHHDGDRRRDGSALKDDTRLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBC4</accession>
    <name>A0ABY7EBC4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_021088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052598">
        <property type="entry name" value="IgSF_CEA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337:SF17">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046369065" description="Ig-like domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="126"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR05719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="288" mass="31485" checksum="0EA1961EAEFF8A5A" modified="2025-10-08" version="1">MFVNYIFVSELFMFFTVNGQACEKLVSLPATQPVLRYDFNYTIQDVIIELVNPNNNPIFRVSCFETCSSAEYLNSTLASTGDITTGKFHIKLDSFGDGQQGNYRFRAPGWEKVVSKCINLYMLGTPSPSTISANSEPYEGGTVKLTCHSISTTDPPGHDLVMSYTWTKDGTNLTSGGRFILLPNTAATLTLNDVQRNGPDNIAFNSTGVSLALSDGDRFSPVACLADCKPSCTFRWTKGQIYVTSSAVLDIGIVGSDDQGIYTCTGTHSIYTTYTNTKNYSVIVLCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBQ9</accession>
    <name>A0ABY7EBQ9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="191" mass="21704" checksum="768DFCFE55AEC132" modified="2025-10-08" version="1" fragment="single">MVPSKGNGWTRTKDGHECNDGSLNSHAVDRHVWNNGSLQKKSIARLRQWMDTIEAMWTPVLYARILLLLNIHYGIAYKQYNNEELPVSDIKTKSNLGDTVSVPDEENDNLSPGLIVFPPNTHPKIIKQTFTREDGHNNDTYSSHDAVPIVEKAGLNGKENSVSEECVIEVEKRSVDRFRHLVFRSDSNFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EC70</accession>
    <name>A0ABY7EC70_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_021640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd17763">
        <property type="entry name" value="UP_hUPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010059">
        <property type="entry name" value="Uridine_phosphorylase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF11">
        <property type="entry name" value="FI09636P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="91"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR06271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="296" mass="33080" checksum="B5BA115BFAA3A289" modified="2025-10-08" version="1">MDIIEDNKTAVFEEGKEDALHTSNGHVKLHNARLKSIQDDHLYHIALSTGSDDLRRLFGDVKVVCFGGQATRMEKFAWFIAREFDVSDTVHNFAAGTDRYAVYKAGPVLSVSHGIGIPSLSIVFQEIVKLIYYAGCENVTFFRIGTCGGIGLEPGTYILGRAVERPAKVDSDLIRQLHACSQNEDKFKTVLGTTLCADDFYEGQGRMDGAFCEHEEEEKLLWLREIADRGVTNMEMESLGFTALCDRANIPGAVCCVTLVDRCEGDGITNNLQLLQEWQTYPQILVARYIRNRLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECN9</accession>
    <name>A0ABY7ECN9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="113" mass="12310" checksum="B814AC48B7A1D8D6" modified="2025-10-08" version="1">MPERPSLELYMCVSLSVVTGGGTPEDVCRVFLLDRGQCPDNGVCTVVDGTPSCFPAQVDDGEKLVLGLAIGIPLFFLACLALVLCALLLYRRRMQKHADNSSSFTERYAVRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDI1</accession>
    <name>A0ABY7EDI1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NF2L2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_020585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd14698">
        <property type="entry name" value="bZIP_CNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.880.10">
        <property type="entry name" value="Transcription factor, Skn-1-like, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047167">
        <property type="entry name" value="NFE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411">
        <property type="entry name" value="NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411:SF55">
        <property type="entry name" value="SEGMENTATION PROTEIN CAP'N'COLLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="735"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="536"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="623"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="814"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="760"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="623"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR05216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="851" mass="95048" checksum="4E87EC9775E8C2C7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEH4</accession>
    <name>A0ABY7EEH4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">R213A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_017155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF16">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DZANK-type" evidence="2">
        <location>
            <begin position="66"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR07197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1396" mass="157913" checksum="4DC436BB4C858625" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFV1</accession>
    <name>A0ABY7EFV1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="593" mass="67291" checksum="0F6F85A46CAE33E5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGX6</accession>
    <name>A0ABY7EGX6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="901" mass="101814" checksum="F86015E6E2ED22F0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EI96</accession>
    <name>A0ABY7EI96_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="157" mass="18175" checksum="A17E88532BE7525E" modified="2025-10-08" version="1">MKLSLKPHLKKGYQIVYSQDSHTDGLKQYLTSLNGGRMECIERFYTYPQESPYNRAEFKVIRDSGDGMLIFWSSCPSQYVSVLRCQSTYNARCAVLNADIGLLVPTIPDDLPLPRVLNDLRETQYLTGSLCRPAVVFLFRYTRQVTDSLLWFRCWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELB1</accession>
    <name>A0ABY7ELB1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_035851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Deltex family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039396">
        <property type="entry name" value="Deltex_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039399">
        <property type="entry name" value="Deltex_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039398">
        <property type="entry name" value="Deltex_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12622">
        <property type="entry name" value="DELTEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18102">
        <property type="entry name" value="DTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Deltex C-terminal" evidence="7">
        <location>
            <begin position="276"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="100"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR10775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="387" mass="44283" checksum="68AFB9EAAFFB5B42" modified="2025-10-08" version="1" fragment="single">GFCKTCGYIGKACLGIHKKGRAFQSHIINIHEEGEEKTKVIMRDITEECCKEHPKEKAIFLCKAHDCMICGRCLHSGHLSCGKQVVDLLQEAGTIDNDKVNNMKQALNELKNDSLRLKEESRLKNETNEVQAEKCYKELDSLETRLKRSVEDIIRNVRNETCKYQDENIEAFSCIAAVCDENVVWADEEEKQIEELVTNSFTGHLCLRSKAFNKAVSGPKLKMKENEHKQTFKIFCLKENEIALKCLFEDMRDVCHIQEEVDGSDDGSAVTHDVGNATSAIQKEEHPSPGQFYEEIQETGFIPDNPRGRKICRMLKIAFKRRLVFTIRDEGVITWNDIHHKTDRRPNSQFGYPDPKYLDRVTEDLALNGITENDIQKDDMLQGTLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EM28</accession>
    <name>A0ABY7EM28_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="52" mass="6448" checksum="6DC4689369104240" modified="2025-10-08" version="1">MFIVIKLENKRGFYFSYFAYRSVRLSAWNSVWWNSLRRAFGFVRRWNCQFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPE5</accession>
    <name>A0ABY7EPE5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IFI44-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_036055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFI44 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241:SF32">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="34"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR10979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="509" mass="55961" checksum="D5D05302E51DD4A8" modified="2025-10-08" version="1">MLTNTISIRIYKCVPQKLLTWYFLLSNHRQAKSAMSCGRLTETDKEQLETWIGGSPKKFTLLYSFTNDGCDVATFHQKCNNQGPTVTVLYNPKGSVYGGFASVGWESSYTWSVDNAAYLFQLKFSGLRKCNRFPAKPGCNTVISSPDHGPAFGPGGCDLNPFCSKAPCLNGIFKLNGNMNTFGTNFDTAGLQSADINNGTMDVTELEVYKLAELLCKELGCYQGPVESAPGDVRILLLGPVGSGKSGFVNTVQSAFSERLRQIAQVGIGENSFTTQRSLRNHKFCIRGLTNNTYKPYRLRTRSGANPNIRLCDIPGVRRGWGLDATELGFLLDGNIPEHYTFHPSVHCSTRSPGFVCKPPRGREVHCVALVVDSAPDMDAETADWLKTFTRIVNERSIPLAILLTKIDLACPTLAEDLSGVFKSQVIETKVNKASSIFGVPRNNVWPVKNYENEACVDDDVTILSLLALQRLVHLAEDYIEGQEIGITERDEEGNGRDHAGEIVESDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPJ4</accession>
    <name>A0ABY7EPJ4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_036115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="62"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="124"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR11039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="323" mass="37037" checksum="F2281E7FCC82F578" modified="2025-10-08" version="1">MANIHVQCEMCCEEEAVGCCNICGNICESCCVIHKKGRAFQNHILKMYGKDGYNSRSIIYDITEEKCKHHPNERALLFCQIHELMICGRCFRSDHISCCHEVVDLCEEAGHVDYDQFNAMSAALNAIKDDSKRIKEEIDRHKERSNTHAVKCKKELDDLENRLKRKVEHSISSFKEEAQKYHDENIAAFSFISSVCEDKVSWAIKEESQLNEFVNNSLTGRLYLMSRNFDKGISEVKRQMKEAEYKNTFKNVCLKENTAALKCLIEDLTDVCELQEEVDGSDEVTTLSIGNATVENEKTRKELFEELIQAKLDTNKAETGQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPJ6</accession>
    <name>A0ABY7EPJ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="108" mass="12315" checksum="AC0728C300C3E725" modified="2025-10-08" version="1">MRINFILDLCARRDAMLIKWVKEVFDKDDTRKKATSQSRESSRSRDPGQCQQTISQFVRMGNVDTASCTPNKGKQPCAPERSPPTPVEVIHEQATTSKEKKNKKSYMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQ30</accession>
    <name>A0ABY7EQ30_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_036310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF116">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046054830" description="C1q domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="96"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR11234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="172" mass="19263" checksum="8EC6E555BAE5F7DB" modified="2025-10-08" version="1">MDTTILRIAILIVLLSNKAIADEPKCYSRFDYDEKMIEKMIRAEIKLEEFAKRMDLNDATVGDIKTDVRNKIQTAKEDVSMDLNDFIQKYVANSTGQLEKIAFYASLSDDISKTTASAPLVFNNVITNIGGGYEPSTGLFTAPTNGLFVFSLTVRQYGYPSYGFEGHFSIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQS9</accession>
    <name>A0ABY7EQS9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">M3K3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_025669</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69349">
        <property type="entry name" value="Phage fibre proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="722"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="598"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="682"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="751"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR11489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="993" mass="107477" checksum="0E8434CDB397FF1E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ES03</accession>
    <name>A0ABY7ES03_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_026089</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="165"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="383"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR11909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="558" mass="63044" checksum="C72B76828C9572BB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ES13</accession>
    <name>A0ABY7ES13_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ACSF3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_026933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="70"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR12753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="601" mass="67050" checksum="D52C800CD7E7C56F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXD6</accession>
    <name>A0ABY7EXD6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_004720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030113">
        <property type="entry name" value="AFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14338">
        <property type="entry name" value="ACTIN FILAMENT-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14338:SF7">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="100"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="485"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="485"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR14615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="553" mass="62739" checksum="8C9C0C84640B0EE8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EYC7</accession>
    <name>A0ABY7EYC7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="93" mass="10381" checksum="B25F65C1CF90BD9E" modified="2025-10-08" version="1" fragment="single">MQEISRLSQSGSSRVRILVHQRKDDSKNSGQKEMRSVSSQTEGTVTIITVGNPAYPSYVVGVRQQQQQQQQQQQQQQVPHSNKSSQLSLTPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1G4</accession>
    <name>A0ABY7F1G4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CASP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_004693</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF8">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00114">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="CARD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p20" evidence="10">
        <location>
            <begin position="344"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="9">
        <location>
            <begin position="495"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR14588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="566" mass="64164" checksum="23F68F01312CE79F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1G8</accession>
    <name>A0ABY7F1G8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TLR1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_030636</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF47">
        <property type="entry name" value="ECDYSTEROIDS_DOPAMINE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="50"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR16042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="401" mass="46043" checksum="261C0CA19DDBADA3" modified="2025-10-08" version="1" fragment="single">TPGRNLSRYDGNNTIITDGPFFDQMNKEQMEIFIYPFVLVIIYMVVGFIGNSIVIYIFTAKWKLTKTTVFILTLAGVDLMSCLINMPTEAAILWNPISFDNDIICKISRFTTFIASVSSSFVLVAISIDRYLMVCRPFLGRELDVKYAKKTCFVAVLLGLVTTWPSLIFYGTFTYHDKVVNSYTNELVTIETKTCLISNFYVENYKLPAGFYFFLFGGHVIMFVILTMLYLLIGRSLFMSTDGGKVTQEKRHSLKYFGLSIVSAFTGTVPNSPNDNRDKSQSVESRARLNRIIADELRHSEVKEFSLRSNTLMMRMVTIAFVISFFPYLVIVTLRYSNPDIPNKLGIAEQIAYHVFLRTYFINSMINPFIYGFMNMEFRAKLKELFCAFCTKYSFRSPVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1M2</accession>
    <name>A0ABY7F1M2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="48785" checksum="E5A410D3A178F592" modified="2025-10-08" version="1" fragment="single">CCIWHLLQRKKRKADLTALPQSDDREVTDSPSQELVHVEQVISTPMEIFKSGDNNGNNSDANSRAIYRRVSQSQEDDPSLNETVDDSNEEIAARIRHFAVAPVFAKYEDPNGRKALLHLDIKSSNIALDLSLNARLIDFGLAREIEGDDGIKCTGDKFDSKWKGEADALSGEEIAKKCISSWSSQRNEVFTFEDVYKSLEELESVRGNYKDELPVERGNYKNELPVDKCDMCLINKGAILRKRKCILDEKSKEDDCQICCTGQKLREIVELSHEIKNKVKNEVMDIRQRINQAQHSKKYIAFIGQLVSVYKDELDKFENRLRVMSSFRIIKNKNSDILMMNGEDFCSNPFILGSDGEDSSLADIARYLRWTEIPRKIDIFLYIPRGNIDFVCLEMVRKDTMDKQDYVFYGDVSKTCRTFALHRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F225</accession>
    <name>A0ABY7F225_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_030837</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF157">
        <property type="entry name" value="DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="156"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR16243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="369" mass="41116" checksum="397E595F0C4DA4AC" modified="2025-10-08" version="1">MDVSKLFGLQFDLKEHQIDTITALLDKNDVSCVLLTGYGKSLCYVLPPLLLVEVDDTVERHIALVISSLLSLISDQKAHLDNRGESFRPEYRHISSVRSIVDVPFLAATATATQRVQDDIKEHLLLADDLVTVAVVPDRPSIFLSVEKCSADNEKELQWLLDLLKETDFKTQTVVFCRSYNAVSLVWSHIVDSFNIHPSNSQLLKVEMFHASTDSIKKEMIINSFKSPESYCPGVYLAFGMGMSVPDINLVVHWGAPHNALSYWQEVGRAGRLGQNAIAVMMAFPRSLMKTLTSEDVRECVKGDVCIRKTILTRLLVDGMEQKDIPTTTPCVSLSCEKCFCEACLCCSACLEAFTCVGKMSSLEKLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3T1</accession>
    <name>A0ABY7F3T1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_005811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR15706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="438" mass="48639" checksum="AC432DE2D1D44C2B" modified="2025-10-08" version="1">MGGVDLHDQFRAKYNIGRCGKKWWRYIFWFILNCCIVNAGILYQQAATRFTNLNFREELLMDLIGGYSKKHRAVVEQLQTPRVADGNQGLHVNVRLPGGKTTCKHHSRFLKTTNTPLVVYGCALRYSVVNDCVYCTQCHLFAGPDACVKTLVTIVLRDWSNISKVVLSHMKSEAHLSNCDSADHFLAIMKGEKKTYYLLDNPFTSREMTLQTEVPHYFSLHNKEIQNHSDPSKLTLAPERERCHRDRLGVCPPHGTARGTLDQIPDCASKSVDNLHGNPLLVSLSPWPASVCPVSMASLYLLCPNGQSLHVLSPWPVFAFSSVSMASICMSFCLHGQSLHSLHVLSPWPASVCHPVSMASLCMSFCLHGQSLCVLLSPWPASACPITMASLCMYSVYMASLCMSYVYMASLCMSSVSMASLCMSFNLHGQSLCVLPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3W8</accession>
    <name>A0ABY7F3W8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="159" mass="18289" checksum="99EBC68F97E45918" modified="2025-10-08" version="1">MNGYKHSRTDALSERLDIHGPHGRRHLCRSSSLNAEVLPKYHDAARSGALWIFASDRKRAHVDNCRKLHEKTRTTGTSERRLVLGLLDDGGVCKRGGARKNVYEERWAILMEYLVIYVPVMFTVLVALCRNRTKRTERQLRIEDSLTCGPNIKRHLNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F509</accession>
    <name>A0ABY7F509_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_030720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="204"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR16126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="771" mass="87699" checksum="598BAFB9937FA614" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5K2</accession>
    <name>A0ABY7F5K2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="182" mass="20459" checksum="4C98832F0C5E33B5" modified="2025-10-08" version="1">MECTKCGSSHESEKCPQCENQTAQTCEFVCDDKLAQQVESEEQFNNLLQFENKLSEDPDTVQESKYDISDEEYEDALSTPESGSPQESEGSEGSYKTACLYPSDPEEDSDLDSESDETPDRTEDKLANESFINPNALETNVDDLSKQFENIELTDNSGHEKKEIRTRKKGQKVEWISTNSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F737</accession>
    <name>A0ABY7F737_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR17755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="165" mass="19065" checksum="31000A1123A553B2" modified="2025-10-08" version="1" fragment="single">MSPNNATASTTDFTMQSTVLHRQSSTPCMRQTIYTRSNEGQMKARSNEDINSHTDNHQHQINRIFSKLSTHMKNRHSGTGLNQLYCQTPQPATLDEIEAHLITLLKSIEDCYKQFNAKTWNTSLKSSIIELKIERDKLYRRANDHTSTLETKLRNEKGKIEKLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7Z3</accession>
    <name>A0ABY7F7Z3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tesmin/TSO1-like CXC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="58998" checksum="0F6AE8B98EF1A21A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9C1</accession>
    <name>A0ABY7F9C1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">INAM2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_000616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029162">
        <property type="entry name" value="InaF-motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34929:SF1">
        <property type="entry name" value="INAF MOTIF CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34929">
        <property type="entry name" value="ZGC:153157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15018">
        <property type="entry name" value="InaF-motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR18778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="127" mass="13687" checksum="D0B9586522BE698C" modified="2025-10-08" version="1">MDKEDGHTTTFTHRSNASHSVPKGPTFSADKNKTKMAAKTNKKWVRLATVLAYVLAVSLAAIILAIYYSLIWDPQLKTTTISTPTTVSGAMSSEGVTKAMLNETTVAAISTSAPEFTGCFVWMILSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9W4</accession>
    <name>A0ABY7F9W4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DFP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_000803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051237">
        <property type="entry name" value="Ferric-chelate_Red/DefProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828">
        <property type="entry name" value="CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828:SF33">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reelin" evidence="2">
        <location>
            <begin position="36"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR18965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="303" mass="31385" checksum="519BBAF4BD6B6990" modified="2025-10-08" version="1">MEISMVPNKVTITLDTIREKGEMIAVFLLAALLPHIRLGTAYSTGAPSGQCDRMIPGHGVRPQMGPAPYIIKFSQPTFGCPEDNITVTLSGAGAGGATFRGFLCETRPNPDLFYTSGVINLPPNSNETHDLCGEGRSITHKQGRVDKTSISFSWTPTVAQPVYIVCTVVAKYNLFWVKLRSNPITFMERACGQQTPPSGGGGQQRPTTTPAADDNSNTASSNTGNSNIGGSNTGTDTGSGSGTSAPDNNSSVMTTVANTNENTGNTGNNASNSASTGTLPPNTTPVGRGSSVAPVLGGMDGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCL4</accession>
    <name>A0ABY7FCL4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF8">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1241" mass="137773" checksum="169151C55E9C8F9E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FF11</accession>
    <name>A0ABY7FF11_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_014714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="100"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR20740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="273" mass="32219" checksum="3BF649B747FC027F" modified="2025-10-08" version="1" fragment="single">MAAPRRLRMALLEHELAQVRFQYNLVLAAILEAAERERQRARRRERRWWVREFILRRPLFGQYETLMKELEAEHAADFKAFLRMEPQMYYELLNRVGPRITKNDAFPLRQYMLKPYPHRHLARDERFFNYRCSRARRVVENAFGILDNRFRRLLTTLEMRPSTVTKTVMACMTLHNLMRTRYPNIQNADLDREDEQGQFIAGAWRDQAVLEDVQAAGNGPYIYTSRDIRPGYGRVPVEFRPSIGRCPLHRSATGTRLSKALSHIGRSSVGVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGN5</accession>
    <name>A0ABY7FGN5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_014736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.30">
        <property type="entry name" value="Designed four-helix bundle protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="135" mass="15515" checksum="2799288ED5AD9A0A" modified="2025-10-08" version="1">MNTYKQGSLLSDSYYFRFAYPSKRLMSAAIVFVAVLLQFRFESQYTDIQKQFNELKDTVDKLSVHIQQIGNDTEALKSDFHNSLVKINSFQESLDEVGENVQHVSNIAETAKEMNDHSIATLKLLEQNIYITKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHI6</accession>
    <name>A0ABY7FHI6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">JERKY-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_015514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR21540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="566" mass="64226" checksum="468100F58126926A" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJ96</accession>
    <name>A0ABY7FJ96_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011735">
        <property type="entry name" value="WlaTC/HtrL_glycosyltransf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09612">
        <property type="entry name" value="HtrL_YibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="345" mass="40200" checksum="5A034B0BEE8C2AB8" modified="2025-10-08" version="1" fragment="single">MTMVRELTRSLGRLFICVVVLVIVCCCFMLVLTKNMDIGESIFKFGRVLHNTNNNVSEASEFRTSTDINPHEDRKHIHRQIYIENVTSSNKYDVTVVTAYFDLGTFRKGFAGNFTTETYLNWCKVLRYLLNPLIVYTDSQKFYNIMKNIRNETVTTTRIHLIKRNSSWAFQLRSNISKVFSQNGYPKHYPNTVIPEYACAQLAKYDVISRASRDDVFKTNYVMWLDVGYFRKRKSTNFFSLRRPNGYNESRVAMNVIQANANMAMPVTAIFRNNIVWVGGGLVFANRDIIPRYETQLKKAVDYFLSRRLMNTDQQVVYALFSDEGRRGIRPHIELQLYNPPVDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJE1</accession>
    <name>A0ABY7FJE1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="301" mass="33398" checksum="CD71A410E6A37CF3" modified="2025-10-08" version="1">MFPLPYQTCFSSSNQHVVHIHSMLSPHFQSMFSLPIPSMCSPPTHSMCSPPTHSMCSPPTHSMCSPPTHSMCSPPTHSMCSPPTHSMCSPPTHSMCSLPIHSMCSPPIHSMCSPPIYSMFSPPTHRMAFMCPNDLATLPRYDPLSMELLDILTGSELGRRELVFMNGDIESSEGVIMGKSGAWEGSGPGEEGPLNPVESCWIIENYERRAVDDAAHDKRLAWLDLPSKWRTDLPVAVDSNRQNASPDTVNTLKKDFILHTMGNGYLYQNCCVRISPGIVVSVLIKSRKAKHSTKYRKLQSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKM8</accession>
    <name>A0ABY7FKM8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="84139" checksum="13AE92723330CFAF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FL39</accession>
    <name>A0ABY7FL39_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAR10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057051">
        <property type="entry name" value="PARP14_RPM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15225">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 35/NMI N-MYC/STAT INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15225:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23222">
        <property type="entry name" value="RRM_PARP14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="155"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="242"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="701"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="786" mass="89962" checksum="9683B5FE3EF3C038" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNL4</accession>
    <name>A0ABY7FNL4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TC1DB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd21451">
        <property type="entry name" value="DLC-like_TCTEX1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF65">
        <property type="entry name" value="TCTEX1 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="262" mass="30082" checksum="5DBE2ADF040C8CB8" modified="2025-10-08" version="1">MTPRELLIICRTARVGDVLGATARGRLVWPVRDQGDHDERVWLPVTPGRQVTRLHNVDMLRIFFVDNKAEQNVVKQDATSVHQPREHYVSWTSKYNSDVTARVSQTVCDDPGADTDDKAYVGTNGTWAKHSGAAGRQTFYQKYEEQKEPSYRMEPTKKFNADEAFNALKSVVDKRMEGFRYHPKFCSNMTKMLSDEIKDEVKKLKFDRYKIVAVVHISEKRGQSMMVASRCAWDKNVDEFATYTMETPTLFCSASVFGIYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPS5</accession>
    <name>A0ABY7FPS5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANAG-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_036548</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.670">
        <property type="entry name" value="N-acetyl-b-d-glucoasminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024240">
        <property type="entry name" value="NAGLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024733">
        <property type="entry name" value="NAGLU_tim-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872:SF1">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05089">
        <property type="entry name" value="NAGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12971">
        <property type="entry name" value="NAGLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047273412" evidence="2">
        <location>
            <begin position="16"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase N-terminal" evidence="4">
        <location>
            <begin position="36"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase tim-barrel" evidence="3">
        <location>
            <begin position="135"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase C-terminal" evidence="5">
        <location>
            <begin position="344"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR22879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="591" mass="67209" checksum="1F9AC2E1077C2CE3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRI0</accession>
    <name>A0ABY7FRI0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TNIP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_015795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.990">
        <property type="entry name" value="Nemo cc2-lz domain - 1d5 darpin complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032419">
        <property type="entry name" value="CC2-LZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038926">
        <property type="entry name" value="CEP55"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31838">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 55 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31838:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 55 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16516">
        <property type="entry name" value="CC2-LZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B essential modulator NEMO CC2-LZ" evidence="4">
        <location>
            <begin position="331"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="534"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="118"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="341"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR21821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="666" mass="75632" checksum="01078CBC944F60BC" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRS6</accession>
    <name>A0ABY7FRS6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">HRH1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_010637</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR24933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF223">
        <property type="entry name" value="HISTAMINE H1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR24933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="435" mass="49834" checksum="D12FB361662B4513" modified="2025-10-08" version="1">MITFSSICLYFNQEHQVSNMFIVSLAIADLIVGLVVMPISTVHIYTDEWLFDIAVCQIWIGIDYTASTASILNLFILSLDRYWSETYKEESSVNDNGRLSSMWIVPIIEWHHFFFVGERSVPSSVCDTEYAKNSAFKVVTAFFNFYLLLAIMYCLYWKIFQEIRKGSELELGQRNVKNYTSPLVNNQSCADDISFSDNNVDTQFDSQSHTHIENPHITHIPIELSILSMSTKHSNNHRTRKTTKGTRCKGYFVKRFLKSPRKDNRFRVIQNGVALELPSTTICQNCKIKYVYDENVIDGETDKVERSFLSIKPQQQPPHALILMNSNNTSAELSTPSTPKSSSSSTEDRRTLANKTANYSLISGLRRIREAEFINDTTCTATSNSKTSESSRNQFVVHDERSRRHSTNVFNMKNRIKNIRQSSALTKEIKAARQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FS65</accession>
    <name>A0ABY7FS65_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid synthase</fullName>
            <ecNumber evidence="1">2.3.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MAR_010779</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H(+) = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.85"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.85" evidence="1"/>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049391">
        <property type="entry name" value="FAS_pseudo-KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF7">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21149">
        <property type="entry name" value="FAS_pseudo-KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="16">
        <location>
            <begin position="1"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAR25075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1513" mass="168223" checksum="53E78F95F9D492BE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSF6</accession>
    <name>A0ABY7FSF6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">CP7A1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_010791</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; bile acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024204">
        <property type="entry name" value="Cyt_P450_CYP7A1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF4">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000047">
        <property type="entry name" value="Cytochrome_CYPVIIA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR25087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="488" mass="56705" checksum="BCC3B47F9F8007A2" modified="2025-10-08" version="1">MVAVSVYLGVILVALVLAYCRIFARRRRKSEPALVPGSFLWGNGKDFAENAVEFIHKSTKKFGDIFTIRLLNQHITIISDPHSYERMCKEKTFDFDPIQKQVNNNVFSFQLIDSKKMIKEASKKVKGQYLFANMNNFSNHLRESFADATCNLPMTDGWCRDGLRSFGSRTMFRAIFRSIFGKEKPEDVFEPVNVYQNFDVFHKYFNFLWLGLPIKLFPSACRALDVLVKMPKSDEILERSDVSDYIKYSTEFMKSHGQTESDIIGHNLVFLHVNYNTFRVSYWLIYYLMKYQDALQALRQEINEFVETKASFCDPEGPVELTLAELDKLPVLNSVLNETIRYTSGVFMVRAVTADTDFCMENGQTYKLRAGDRVAIYPPAIHKDPEIFENPLEFKYDRFVDATFYKNGRELKNPLLAFGSLCPGKKLAMTQAKWFIFNLAHNFDFETVDGQTCEPDVHYHGHEILPPTRDVEILYRRKENRRPVEFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTF4</accession>
    <name>A0ABY7FTF4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="167" mass="18529" checksum="CD890E91027B3046" modified="2025-10-08" version="1">MTLVNADHNGSTFAALATVPIRRYGVPVASETASSPTMPDGVKKTVYITKTGTAPTPSLMKKAFALKTLLMEPFLEAENVKECILYTDQQLYTLLTTLKQNPRTVASIVLACVFLHISMRVRFVHEHNGLVDEEDNNHQLGSQPVRDEFKQNVVAVTTRRRRGDSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FU20</accession>
    <name>A0ABY7FU20_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">M3K1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_037992</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd16494">
        <property type="entry name" value="RING-CH-C4HC3_ZSWM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="217"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1079"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="612"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="703"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="939"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="563"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="713"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="939"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR24323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1328" mass="148216" checksum="200A9A45036A81CC" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FW74</accession>
    <name>A0ABY7FW74_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR24981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="81" mass="9381" checksum="1B3941016F7F4360" modified="2025-10-08" version="1">MIYGKRDVLCDKNKPPCAYNSLEQYGDDPCLSLHNGSQDLLHLGLLRRPIGPMVHWKVLPQNYQLEQIEKESQIHDKNLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWV9</accession>
    <name>A0ABY7FWV9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF1">
        <property type="entry name" value="AT07410P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21769" checksum="36DB8188D29E76F4" modified="2025-10-08" version="1">MGNHFVPDEPISKSIGVVWDEDFEKLTYMNLIDNISLAAISRESDEMMGVRISGFWRRSDGLTDLSWMKEGGDTKNLFTFITHREAELDFFNRYNVEEAFHFYCLGVRRNYRHHHVGEHLLQGATEFAKALGFPAVKGEGTGPYSQRIYEHSGFEIAMTMPYDRYFVNGRAIAEGTGDIKMTKVYVKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXX1</accession>
    <name>A0ABY7FXX1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ASO-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_011370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd13858">
        <property type="entry name" value="CuRO_1_tcLCC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13884">
        <property type="entry name" value="CuRO_2_tcLCC_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13905">
        <property type="entry name" value="CuRO_3_tcLLC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045426266" evidence="7">
        <location>
            <begin position="21"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="679"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="89"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="244"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="476"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="642"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="646"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR25666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="713" mass="78520" checksum="C29DA7D16872FB01" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G197</accession>
    <name>A0ABY7G197_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_013894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046840904" description="EF-hand domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR28190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="216" mass="23923" checksum="910C769BE843B2EA" modified="2025-10-08" version="1">MPEERSNTMLFKYTLILVICIILIDPSDAKKEKKKSKKKEKRKTKTKEKRSVTDVEPPKLGCKAQFSVVCPVDMTAADVAIAGGTARTGTVVAAFAAAGVAVRKNACKVEEKNTCKLLLPPVFKAGNRWSGRVPFSDDISDYDVNGDKRVNYEEFVFAVTRTVNLAEPTELRRPFTFADVNGDGELDTQEFIAAPFLFAHVEHSKSTNTMSTIIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3S8</accession>
    <name>A0ABY7G3S8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_013638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046369094" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="105"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR27934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="204" mass="22577" checksum="884425BECF0690B0" modified="2025-10-08" version="1">MRSSWHHVVMKLCLMLVCHSLLQLLANVRGDISVQDYSKYTGSSAITGTSLGKTSARSVVRCSTLCSRHEEEKGERCHAARYHGETRACELMSRSGEGAEEWLVDGQWNIYVIQAAVDWYTARDSCIQMGATLAVITTLGENGFLKGLLESVYGSHYYWLGANDVLQESVFKWETGEDWASLLGQWPLGYNPSGILGTTAWVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3T0</accession>
    <name>A0ABY7G3T0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_014266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="3">
        <location>
            <begin position="30"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR28562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="89" mass="9332" checksum="86BC973C4A1B1A45" modified="2025-10-08" version="1" fragment="single">EMDQCKALCPADGSGQVQPCKLNAGICLETDCATSPSVENGTILGNVYLEGSKLKVACNQGYEPLPGMAISQCENGTWTHALNCGTCMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3Z4</accession>
    <name>A0ABY7G3Z4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_013948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="2">
        <location>
            <begin position="555"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR28244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1074" mass="121181" checksum="7A86E48F7F12051A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5K2</accession>
    <name>A0ABY7G5K2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HMCN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_003281</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C1q" evidence="6">
        <location>
            <begin position="556"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR29713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="640" mass="70945" checksum="994F2CE6F4FA921E" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6C7</accession>
    <name>A0ABY7G6C7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF5">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="291" mass="33979" checksum="B43E4CFCE8913348" modified="2025-10-08" version="1" fragment="single">MQLVSCLTHRLNFAVKIVSKGLRMDDIIDVFNLVYYFYKVSLVPAFLEICFRNELTTVSLTLQREDIDLSSTVTKQQASELNLKYIHANQSQVLDDSPLDNDTDSYMYKESTLQNFIPDETLIRHKKQIVQSMLDWLHRPECTRCNAFDHKNWPNNDNSALLQYGTDEVKHVFHHFQLLLENAYCDLNGALREFSELKLHVTKIHRGISHKDEDKGDFVNILKIIHLTSVSPFFERVKNDWRCGLSTETLDQLLRIVLSGRPLEDFNARPVVNRWWISGQRKKRPNVVSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7V6</accession>
    <name>A0ABY7G7V6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBAC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_033044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd14303">
        <property type="entry name" value="UBA1_KPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041926">
        <property type="entry name" value="UBA1_UBAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052476">
        <property type="entry name" value="UBAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46738">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46738:SF1">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="402"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="534"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR30502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="709" mass="79919" checksum="DCE463468D24EF6C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G816</accession>
    <name>A0ABY7G816_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="127" mass="14658" checksum="27C5BBF44B1C15BF" modified="2025-10-08" version="1" fragment="single">MTMSNVSKNEEEDLSSRLVNLFMGEINPSEMEDDPMLNDLSSALQRALTKFKQYGTLTKVHRGSVVFYIQLDSFLSFINCYDDVLAGKLTTEFKPLEMELLKRLQRPNLELNVIINTNEVQHFLQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8V0</accession>
    <name>A0ABY7G8V0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR30332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="245" mass="30123" checksum="3D287D7A9C125EA5" modified="2025-10-08" version="1">MCTERLTNLTAYGNEPNEDHFENWSEGDRDAHPELPFAGTPGLTDGLGECQTPLHYFQTLLPGETDTMVEETNRCFFLLLHFHFLLYFHFHFLLVLFLFLFLFFFLFLFLFLFLFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFSFFFREISGGGGGGGGGGGGGGGGGGGGGGGGGEYNQKLDTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GE67</accession>
    <name>A0ABY7GE67_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897:SF2">
        <property type="entry name" value="OS03G0226600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897">
        <property type="entry name" value="OS10G0105400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2596" mass="290181" checksum="DC6FEF0E0F15671E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCC2</accession>
    <name>A0ABY7DCC2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="10904" checksum="13036E7684585C74" modified="2025-10-08" version="1">MHIMRILKLNSYLHRLSERALYCDTDSITFTSGPGPLKPTPGDYLGDLTDEVPWTKETRIKGTSNESVVKITHSKIFGDVTNTALFTISKGKSIRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCC7</accession>
    <name>A0ABY7DCC7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="387" mass="44459" checksum="792098E689452BE3" modified="2025-10-08" version="1">MTIFIIVNGLSCVQDEYDDDSTVNELSSVQDRNETDNIVNGLSCVQDENYNDNITNELSRIQDRNENDNIVNELSSVQNRNENDNIVNELSRVQDVYETDNIVNGLSHVQDVNEDDFIVKKSCQVYKMLIKMTIPLMNHVNEAGNKVNQSSRVQDVNKGDNTMNESSIAQDINKGDNTVNKLSNVQGVNEDKNTRPTPKKLRYIDSGSDSDNVPLINLVCDWKNIASDCSDIDDDLDKPYQPCSKDLNSTDTEYMSDVSEKTKNDRKRKIKTKPVFIKAIRNKHQIKKDIDRKSGAVNSLNTSQRNERKTSREGYNDASFDKRSPNISKEQSATLQSVTKGSYREEMQEYRQMKVCRINFSKVMDWRVKTNLGQKISWRQMRHIRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDB8</accession>
    <name>A0ABY7DDB8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="261" mass="29181" checksum="9368694DB7D99D9D" modified="2025-10-08" version="1" fragment="single">MIEQKQRGDDSAIARVEVLGVQAELRRAPEVPTDEVEARSETEALEPKDNEIEPQVDHLGVKAEQTSPSTEDITELDEEEGTRTPPPSPIEKLVQEMKDDNIKEAIEQEALKEEQEALKEAQEVEQEPQEEPTKLVEPPRIELTESDTPTGEAFDFEDGGEKVEDTAEMPEEKADAEKLVEEEISESVTEIEEIFQVSEDGVHWKTVKKITTITPRGTTERVEVLGEETAERKDSAIDQLAARLSEPRDDSAPNDRPDGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDD8</accession>
    <name>A0ABY7DDD8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B2CL2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_007414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Bcl-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06845">
        <property type="entry name" value="Bcl-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256:SF50">
        <property type="entry name" value="APOPTOSIS REGULATOR CED-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256">
        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01862">
        <property type="entry name" value="BCL2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Bcl-2 Bcl-2 homology region 1-3" evidence="4">
        <location>
            <begin position="64"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ94943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="200" mass="23315" checksum="29D8EAE51404E000" modified="2025-10-08" version="1">MEKGNEGGNEEGREGVFDFAEFFMEKFSERKVDDYMNYKIHKHGFTWQISPTKNTHENKVTSTMRALCREFEQNYEKKFDDICRTCASVDTNSDNYMNILSELVDGEPTWGRVVAIFAFAGALAVYRLEQGHEKDVDMIREWTCSFMHKHVDDWIAKEGGWKGLVKFYEQLQERRMGGWWSIIVVVIGAVCLEALSVIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFS0</accession>
    <name>A0ABY7DFS0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ93860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="106" mass="11828" checksum="6F3D8C7AC7D8A452" modified="2025-10-08" version="1">MINETAIPLGCQSSCPNLLVTMVNKFNDSDPCGFIVSKECILNYLVECSNDTVRLNIANQRGGQSDIQNPGDNQSESSIQRRRNGLIEINRLLEKETYKYPGTNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DG32</accession>
    <name>A0ABY7DG32_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OVCH1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253:SF176">
        <property type="entry name" value="CORIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253">
        <property type="entry name" value="TRANSMEMBRANE PROTEASE SERINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ95305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="130" mass="14655" checksum="CCE9E4F4898515D7" modified="2025-10-08" version="1">MYCRWNDYTRPVCLPDASHGYQVDTGDEEQLNQLMYPILDDSICANHWPDFLPANELCAGYENQNKDFCGDDIGSPLVCKKQNGAWYVEGLASSGGNCTTANEPGIFEDVTVYQNWVLTTMENAGYPYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGH7</accession>
    <name>A0ABY7DGH7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="292"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="358" mass="39984" checksum="07EA08CF5460EE6A" modified="2025-10-08" version="1">MDFLNQTNIQWGSYAVTPWTAVPSTVMYNATLGVFTTVFDTNIPNSGYLYAKYDLSGGCGYIYFRTPNPVLGKIIEIGYYPAPAVIGLTGDYSREWYNESSSSSMTLTEGLLTEEELPNKEFVLTIYNATRWTTGSYSVKCTKSTTDSLYTERVYVKVIVPPGQPFLQSKRIVQDCPKCLVQICTSMCFAIHLGALSYIYLDDEKYNVNRDPPWGNIYRISRFIRAEDYMKTVTCSVLNAALKKPLTTSAKLFVALKPEIPVLNVPILREGSPANITCISRGGRPAANLNPPTMLTMDAPSIPRYLQDSYTLKFSCFTDTYNDNCLVSWTKDSQLDHANGEVTNKTTRLSFNGVCGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIG8</accession>
    <name>A0ABY7DIG8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IRF2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_030122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00103">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001346">
        <property type="entry name" value="Interferon_reg_fact_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949:SF17">
        <property type="entry name" value="IRF TRYPTOPHAN PENTAD REPEAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00605">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00267">
        <property type="entry name" value="INTFRNREGFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00348">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51507">
        <property type="entry name" value="IRF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRF tryptophan pentad repeat" evidence="2">
        <location>
            <begin position="17"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="370" mass="41623" checksum="D58371FA68BF24C0" modified="2025-10-08" version="1">MSRRGCRKLGLIRPTDRPRMRDWLMEKLDGCHLPGMEWVDRKQKVFRIKWCHGSRHGYCYNDSLVFEAWAKHTGRYDEDNKEPKRWKANFRCAIKSLNDIQEMNNSVTKGQNAFRVFQILEASMPKKRAATSSVVRSRPAKQRISETADVDVSPSTSHADSGICDDDEVSDAETDFRMSTSKQTGWTLIQDVESVSRLPLGRHTGSCDQEPTAGTSYGSAKSIRELTFTLPLFEKICPDLTKIEFGKEHIIQRHHSGFTVELVTNATSVTSSAVLPTVTLPGVTLFQDLQSKVTYQAQGHTGHFPPIPAECGQYSEDFPDVAEEVVLETTPDDVIQFIPQPDDVTQTVFIETSTGTENIVQYTVLNNFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJ02</accession>
    <name>A0ABY7DJ02_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_029015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="150"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ96325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="242" mass="27716" checksum="48B360EBD94F22A7" modified="2025-10-08" version="1">MAFGGSSIYKGSDLIHDYSCSKCDDNDFNTEAQHFCPECEHYLCDKCVRIHGEYFKKHAVYGRGDIKKWAGFSMDRCDQHGNKLEVHCDDHKNCVAILCSSIRHLPELARGFLKTAEFKQLPTAMDKMLSRLNELKNGKMEDQASLKVSYKNILVEIKALRKKLNQILDKLEQKTVEQLDSMMKDLEKTLKDDIKTCAHMNELLKTMMDKCRQIIGKKQGDQLLRRAQDMSNKTDGSPESSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJ41</accession>
    <name>A0ABY7DJ41_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CB081-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_030034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028042">
        <property type="entry name" value="DUF4639"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34438:SF1">
        <property type="entry name" value="CHROMOSOME 2 OPEN READING FRAME 81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34438">
        <property type="entry name" value="SI:DKEY-97L20.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15479">
        <property type="entry name" value="DUF4639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="507" mass="56872" checksum="3B248CF732B81396" modified="2025-10-08" version="1">MSVGEQKRQVNSHHLLHWPVVQRVEGLEYTGDSEASQMVLISYGPAENGQSEGVVHLAPSTKADRRMSKAAVSKSRAEKAGKLPQAQTPVVSHEIVPGKFNDHDWNMMVDKDGAEDYVDDIVDDLIDITLGKCYELYIQRQLIPFTVSQAKDAILSIIEWQFLKRDDGEKAPETDGGWMQDEEPDPAETDCWAQGSVPRQFLPTPVVEVLHEEAEELEEEDGNQELEEEQDEVVIQDDPELEDVVSEPDEVAKEEAERLAREEEEKAKAEAEKKKKRKFKRYTGKIRPVDNNKMTESLEQTEMTLLSAEIAASMPRPNANMGPIVTMPASCHSILRVQAGRPPGNKDVEYDDYGNVVAVIRLNPEKLPSHRVKVNYRVIDPAVEAAQARLDSMKTGRYVAPKPRTKRQQPAEQSKDTIETMEVAPGVTIKEGGRLKHGPSRYIRRIDMLNQNQMGLKPVSTKMSTPRLNVTDILDRHTPILRPIHDNSPLPPIMAVPHPPAKPKIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKB5</accession>
    <name>A0ABY7DKB5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LYAG-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_029624</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00111">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.110.10">
        <property type="entry name" value="Spasmolytic Protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044913">
        <property type="entry name" value="P_trefoil_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF131">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 31 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00088">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00018">
        <property type="entry name" value="PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51448">
        <property type="entry name" value="P_TREFOIL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="10">
        <location>
            <begin position="108"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAQ96934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="924" mass="104189" checksum="CB37B6C987A85209" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKI7</accession>
    <name>A0ABY7DKI7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="452" mass="50810" checksum="55995DC337016D7B" modified="2025-10-08" version="1" fragment="single">IETSKSLTQKVFGPKFHRKFPTTRLEQFDDCPAGVWPTTSNDAYETTGVNLKLGVGQSIQMPVNGILKVFKFEKKVVIQAIDPEFEGTEIVIENIDADQTNHGKNVDAGKKIGKVTYARRCKPLTNSDRLSTKESRGKNYIHVSVRPFDKSIDTPPDAEYEYKDPSPYLDRLVPIPKWIQDCNDHEFRYIGQTFESGESAENEDPDQKEEPIKRIREPDPDTLDEMLGDEDPTYRPDDPELYDPSSFEDSLMKSLKEQGKKFAGLFKTALYGKNGPKVPNFLEVIDINGKTVDWLLTKLSKTSEIGKKFIGIVNQLAFAKQSDPFEAVATMTPYTMLTYLKNNDANFKFGGSSDGPSEIRARDNTLKFGDPDQMILTMASLAEKICPAFRAKIAKGFGHVCFAYDDCLGLRCNVPFSSGANTTPLYASFRHKPSDTAIVVEIMNRTRHLLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DM42</accession>
    <name>A0ABY7DM42_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617:SF3">
        <property type="entry name" value="CORE-BINDING (CB) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23874" checksum="005B582B4838DB2D" modified="2025-10-08" version="1">MKNLNFKKGNYDAFMKVSPIIKEYLDWWIGNIETSFKPVQIGNPHFIIETDSSDDSTEVILSSWRISTRKTYATYIKKWFLFTQMIHQYDKDPKSCIVHTFREYLDRTAALRGKVTKLLVTTQKPHPAASRDTVSRWVKSLLTSAGVDKCFKPHSVRSASVSKAKDKGVKLETILKSAGWSNARTFARFYNKPIADDHSFENAILNNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMI0</accession>
    <name>A0ABY7DMI0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="143" mass="16772" checksum="16E8C8967E095251" modified="2025-10-08" version="1" fragment="single">MAATCPSPNLERQKKVLKRQNKCEIPRLLLYSMLPMPVWIGFSLAIGSMLGIRRVWQGIVYYWAMSGFGAVTFRLICYHPFIMNTMVPKGKWNAWVEDQIIIDKPYTTIWTNFKNRFSNTVSDSSVMFNVIYCKMFVMLFDYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMY8</accession>
    <name>A0ABY7DMY8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YPF17-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47202:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47202">
        <property type="entry name" value="HISTIDINE-RICH GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="271" mass="33369" checksum="D10BF031423195FF" modified="2025-10-08" version="1">MHTKKYCKSSMRTTKNCKIRKRTSKYCKISMHTTTYRKINMGTTKYCEINKCTTKYCKIKDREINKRSTKYHKINMHTTKYPKINMPKTKNYHQTYNKISMRTTKYRNISMRTTKYRNISMRTTKYRNISMHTTKYRNISMHTTKYRNISMHTTKYRNISMHTTKYRNISMPTTKYRNISMRTTMYRNISMHTTKYRNISMHTTKYRNISMRTTKYRNISMHTTKYRKISMRKTKYRNISMHTTKYRNISMLTTKYRKISMRTTKYRNISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNA5</accession>
    <name>A0ABY7DNA5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CAPR2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_023550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF33">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="C1q" evidence="4">
        <location>
            <begin position="91"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="4">
        <location>
            <begin position="337"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ99177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="474" mass="52343" checksum="119CBDA595FCE683" modified="2025-10-08" version="1">MTEELSNLVNKLITEKMSLAEQEIQGMKQKIQSLEEHVALLDASCGEQTSTKNAANAFDDAKGNNPRNMVANYTEKQSLTSPQQRSRRAVGASAHISFTAYQVGTMSNMVPGQAVRFNHVLHNDGDGYNTYTGAFTAPVNGTYMFTFHFDSRVHTFVRLVLDGRNLVDAVANQHPGAAQMERETMSGNTAIVHVNHGQAVIVEVYDVNGEVASSDKYRLSTFSVNSEINAKDVTIDKTNELILTLYDVIYELKGRLESLETKVTKLRHENNGQVELIEKLRTEIIIKGNVLNRELDQETNKRSLNNNDDFNNSGTRVISEENNGIAGEPSISFQTLPRARRALANVAFSAYLSHPLSHVTNKALLNDGNGYNASTGTFTAPLSGVYMFNFHFDSRALSFLKLVIDGVNQVDAVANRHVLNDFNDRKAQSMGGNTCIVHVNHGQVVQLRVYETPNSDVASGDTFRLSTFSGVLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRS5</accession>
    <name>A0ABY7DRS5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bis(monoacylglycero)phosphate synthase CLN5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ceroid-lipofuscinosis neuronal protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Palmitoyl protein thioesterase CLN5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-depalmitoylase CLN5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_023679</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the synthesis of bis(monoacylglycero)phosphate (BMP) via transacylation of 2 molecules of lysophosphatidylglycerol (LPG). BMP also known as lysobisphosphatidic acid plays a key role in the formation of intraluminal vesicles and in maintaining intracellular cholesterol homeostasis. Can use only LPG as the exclusive lysophospholipid acyl donor for base exchange and displays BMP synthase activity towards various LPGs (LPG 14:0, LPG 16:0, LPG 18:0, LPG 18:1) with a higher preference for longer chain lengths. Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity in vitro and most likely plays a role in protein S-depalmitoylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + sn-glycero-3-phospho-(1'-sn-glycerol)</text>
            <dbReference type="Rhea" id="RHEA:77599"/>
            <dbReference type="ChEBI" id="CHEBI:64717"/>
            <dbReference type="ChEBI" id="CHEBI:72828"/>
            <dbReference type="ChEBI" id="CHEBI:232637"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77600"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-acyl-sn-glycero-3-phospho-(3'-acyl-sn-1'-glycerol) + sn-glycero-3-phospho-(1'-sn-glycerol)</text>
            <dbReference type="Rhea" id="RHEA:77619"/>
            <dbReference type="ChEBI" id="CHEBI:64717"/>
            <dbReference type="ChEBI" id="CHEBI:64840"/>
            <dbReference type="ChEBI" id="CHEBI:232628"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:77620"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-hexadecanoyl-sn-glycero-3-phospho-(3'-hexadecanoyl-1'-sn-glycerol) + sn-glycero-3-phospho-(1'-sn-glycerol)</text>
            <dbReference type="Rhea" id="RHEA:77607"/>
            <dbReference type="ChEBI" id="CHEBI:64717"/>
            <dbReference type="ChEBI" id="CHEBI:75158"/>
            <dbReference type="ChEBI" id="CHEBI:232639"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:77608"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-octadecanoyl-sn-glycero-3-phospho-(3'-octadecanoyl-1'-sn-glycerol) + sn-glycero-3-phospho-(1'-sn-glycerol)</text>
            <dbReference type="Rhea" id="RHEA:77603"/>
            <dbReference type="ChEBI" id="CHEBI:64717"/>
            <dbReference type="ChEBI" id="CHEBI:72827"/>
            <dbReference type="ChEBI" id="CHEBI:232638"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:77604"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-tetradecanoyl-sn-glycero-3-phospho-(3'-tetradecanoyl-1'-sn-glycerol) + sn-glycero-3-phospho-(1'-sn-glycerol)</text>
            <dbReference type="Rhea" id="RHEA:77611"/>
            <dbReference type="ChEBI" id="CHEBI:64717"/>
            <dbReference type="ChEBI" id="CHEBI:72826"/>
            <dbReference type="ChEBI" id="CHEBI:232640"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:77612"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19234"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CLN5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026138">
        <property type="entry name" value="CLN5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15380:SF2">
        <property type="entry name" value="CEROID-LIPOFUSCINOSIS NEURONAL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15380">
        <property type="entry name" value="CEROID-LIPOFUSCINOSIS, NEURONAL 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15014">
        <property type="entry name" value="CLN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAQ99306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="413" mass="48535" checksum="DA78E3908F10AD0F" modified="2025-10-08" version="1" fragment="single">MQIKFGINWQDRQEQDDGWNTVEELSMDMKSSSERSAFADDLNEQFKMSIDTSQGPVHPYRRFKSRPKFNPYCQAGVVPFCPTGRVDNTMPRFHDFDKIEVYALKAPVFEFKLGDLLGKFHIMHDAMAFKNLDTGFNYTLEWYELVELFNCTFAHTLEDDSMIWCNQGAACIYDGVDDKHWLEYGTLVKVAEITGAISNQFAEWVEWDNNTAIYYETWTVWDEPGGQMWFDSFDCASFVIRAFQELANLGTEFNQSVHLNYTRINLYSDKPVYLGNDTVVKANESLYQNITDFYKKFQSHQSFQDLMTHLIEGYDEVFEDHMFYLYYNFEYWFLPMKQPYMKLTYFEKPLPKANNTDTLPIDDGNLFCVLQLKALDPTQCRNAMLFKENSPMGKVKVEDQYKLVFFMILKNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRT5</accession>
    <name>A0ABY7DRT5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PIAS3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_023428</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIAS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd16790">
        <property type="entry name" value="SP-RING_PIAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF94">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 2-10, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="12">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PINIT" evidence="14">
        <location>
            <begin position="142"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="13">
        <location>
            <begin position="290"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="390"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="475"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="559"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="647"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="619"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="667"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAQ99055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="688" mass="75346" checksum="04022A2FA12710CE" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DV81</accession>
    <name>A0ABY7DV81_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_008181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="747"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="978"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="880"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="608"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="796"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="815"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="855"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="986"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR01623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1163" mass="129002" checksum="5F7B79C21D373F68" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVE1</accession>
    <name>A0ABY7DVE1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">GP161-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MAR_008236</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF10">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAR01678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="212" mass="25248" checksum="A0A98144C086EDD4" modified="2025-10-08" version="1">MSNFHGNRFVRHNYREFCRIHFCYSDIYTRPVLLTMSMVYICNIMHTVALMPFVFTLRMFQECLFGYCWCQVSGFGMNLIFTAITFTLVLIAVDRYLAVSKQLYYTMAFASRRAFSMIASSWICESEQRRQSSAQILIHTRCCSRKTGSVLWRRDERKAALTCFMFLFSFISCWLWYFIIIIRECILDDPDCIEPVVNIRRCQCYFPYQVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVU1</accession>
    <name>A0ABY7DVU1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SIR3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="929"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="959" mass="106764" checksum="992F633F59F22563" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DW32</accession>
    <name>A0ABY7DW32_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="218" mass="23362" checksum="11E1EE7E39D640E5" modified="2025-10-08" version="1">MSLTTALWIMSLTATLWIMSLTAELWIMSLTAALLIMSLTAALTVDNVPDCSIVDNVPDCSSVDNVPDCNSVDNFPHCSSVDTVPDCSTMDTVPDCSSVNTVPDCNSVDNVPDCSSVDNVPDCSSVDNVPDCSIVDNFPNCSTVVNALTAVLWIMSLPAALWIMSLTAALWIMSLTAALWMMSLTAALWIMSLTAALYISLLHAALWIMSLTAALWIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXV4</accession>
    <name>A0ABY7DXV4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_008021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF5">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28127" checksum="10F60C4BA01364D9" modified="2025-10-08" version="1" fragment="single">LAEQDLWIPEQICLTIAEQFAAKTIHSVHLCAPKCCSILSSKETTRLLPKKFSYGFLSKKNWKAISTEIAQKTSCFHIERSKQSDLENMHLERAFSVAHFLMKQFIANLKFEPLLSEGSKQEIFETIGQTIKSEIVENVKESEAFGLLTDEVSDISVTENLSANALAIKTLIANNLKVNGIDIRKLTGFASDGAAVMVGKVNGVATQLRKDSPSLINVHCVCHRLALACTGSNQSLKYIEKVETLLRQLSLAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYU1</accession>
    <name>A0ABY7DYU1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PIF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_009228</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13245">
        <property type="entry name" value="AAA_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="3">
        <location>
            <begin position="363"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="591"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR02670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1653" mass="189820" checksum="AAAAB45D95CC36F4" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E163</accession>
    <name>A0ABY7E163_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">guanylate cyclase</fullName>
            <ecNumber evidence="1">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_010298</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="4.6.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR03740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="69" mass="7678" checksum="DB7C55CA1D715149" modified="2025-10-08" version="1">MSFLMDLIRGMDFLHKSVVRSHGNLKSSNCVIDSRWVLKLTDYGALCCSQEDEVCTSGSDDCCGRPRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3N4</accession>
    <name>A0ABY7E3N4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="159" mass="18954" checksum="8D2782E293882CAB" modified="2025-10-08" version="1">MSFSGKIYQLSDVNEIYQLSDVNEIYQLSDVNEIYQLSDVNEIYQLSDVNEIYQLSDVNEIYQLSDVNEIYQLSDVNKIFQLSDVIRYINYRICNEIYQLSDVNKIFQLSDVHEIYQLSDVNEIYQLSDKLWPDMARNLKHVFYVHFTTSFLLRNDKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3V9</accession>
    <name>A0ABY7E3V9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="11" mass="1434" checksum="CFA5C3225699C732" modified="2025-10-08" version="1">MHSVLFMYRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4I7</accession>
    <name>A0ABY7E4I7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8193" checksum="02D6F64495CF8B7D" modified="2025-10-08" version="1">MRAAKVSIQAANVRHQAEKVSKQAEEEIIKAAKYNMFLLQFPTRQCDNTVDGYVTLVSHASQLKFLFNPGHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E614</accession>
    <name>A0ABY7E614_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="29043" checksum="E5102A27CE5E227F" modified="2025-10-08" version="1">MGKAKSCKAQFPCGKCEKQRNTGCLFSRPTSPDNCLRQWSVKIRENPQSFLVYHFCTGNLVVGSDDEQALSKSIQRSFPGATHIQCTRHLKNNVKDYLCHKIGVRDDEKNKIIQSLFGEYGLADSDSTVIFDHRFETVHNLVSEQAAGFLPYLNGRIVPLIKNHVHIPKRVRNWTNNNTESMNNLLKIGTNHKVENMTDLIDIIYRIVQSMYKDVEKSIVSMGNYKLTQPYEHHKMSVDAWCQKTEQGRNGILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6N2</accession>
    <name>A0ABY7E6N2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTG3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_020213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033332">
        <property type="entry name" value="BTG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978">
        <property type="entry name" value="B-CELL TRANSLOCATION GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978:SF44">
        <property type="entry name" value="PROTEIN BTG3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00310">
        <property type="entry name" value="ANTIPRLFBTG1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-proliferative protein" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR04844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="276" mass="31568" checksum="2A78F5FD30284A1A" modified="2025-10-08" version="1">MREEIAAAVVFVTRLIKLNDSIPKEKLEEFSTELSSTLVEKFKNHWYDEQPSKGQGYRCIRINPLEPTDPAILKAASQCGLQYNDLNLPQELSLTLWVDPKEVCCRFGESHGSFCQLAVQKEDGNMENQAHTINIEDLVKQQQQRFNMNLNITTTRTSANKLKALAMKNAFNQQANGYHYYSKYHHNAMNNNQHQNGHTPRPFHKTHHHNHQSHYHKNAPHHSSSVNSHERKGSGDFNGVSGNVNGAAQGKDRYRWVRNSKPMPAQQTESMRLSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EC29</accession>
    <name>A0ABY7EC29_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="426" mass="47916" checksum="A977F0E535E92039" modified="2025-10-08" version="1">MPGISFVHHISTFSKRAKKRFRLLPFKLDILLFLFPFPIPFQCFSLFSENGSYYFTLINAKAIYNNTLFYAECAYNPSMKSQIIELDLEVPQNSVVVGPQYGDFFKTKCVYADAGIDIFCKTDTGIDPVSVSFSVGGKVLPLLADGKEPELRKLDNTRLRLKKEMAGSNLTCKVVYSANKAPVEFTAHLCYLEFGTGPTLIEPSCFYGDDSTATCEMHNIRPVQKIEIRVNDRILKVQQQDEYDRSKNTFSSKATLKTASKEWNGTEMCCTSRIGNNNIGRSICKPILMSCMQTNERSSLFVSFWLPIIAVYQTSARDKTRSNMNKHEPVYSTIDDPIDTAIRSTMTFSRQMSASAQSTGYMTPISRTTTSEQITLTNLRKIDSVHITTNDEPHTSEIARQDKVNDADAPTANKEYIDMSGSTHIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDS6</accession>
    <name>A0ABY7EDS6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="252" mass="28130" checksum="FF33A1354DDC320D" modified="2025-10-08" version="1">MDAALPDHEATTTRNVSRQKRPKLSSECKQNLSHKDLSVDAFNASMHASSQSDLSLDQDYGHHSATSSCQAFEGSVRCASVEELAMDQGSLLGMGSQVDQESTDNDSGCLHGENELEDLLYHFRQFFRHQIDQEMSMMHERMYMMLENQQTHVRRIVNTAISGTWNNSPQLPASEPANQNFAEIFQDDDHSTKDETDQQQNCLTVTTRYPQIPVTTASCTNHAQPSQEQDLLGLLSASCSVSSLLAKPQFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EE13</accession>
    <name>A0ABY7EE13_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_016934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="702" mass="79199" checksum="ED7BF2815C2188E3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EE16</accession>
    <name>A0ABY7EE16_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_016896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF113">
        <property type="entry name" value="COMPLEMENT C1Q-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C1q" evidence="4">
        <location>
            <begin position="5"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR06938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="138" mass="14930" checksum="B6EC0F4A66C10284" modified="2025-10-08" version="1">MAGAFQPPPVAFMTELTQSMSGVNYPLIFDKVTINEGNAYNTLHGNFVAPYNGTYLFTVTSCAVGGHFNTLDILVDGTTFGSVRCGDTNYHECSTKVFIKALTAGDDVYIRHQNYGDSIYASSIEGYPVFGGALLHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EF94</accession>
    <name>A0ABY7EF94_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HUNK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_017449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF79">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="38"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="353"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="500"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="663"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="678"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="691"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR07491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="702" mass="78612" checksum="3DF016724E148B31" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFF1</accession>
    <name>A0ABY7EFF1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="61" mass="7008" checksum="3EEEDC8E4ACB2818" modified="2025-10-08" version="1">MSYLHEQKLEKRNSTDGMMSFVKKATKNNDQVYSDLGGRGAGRANLKLISFTCKQLQWVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGK7</accession>
    <name>A0ABY7EGK7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RBL2A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="165" mass="18451" checksum="F2F824E2EE9E0C2E" modified="2025-10-08" version="1">MAKNGEPDYDQLGDKGECKVKIICLGDSAVGKSNKPQQLSTYALTLFNYKTKVNDTDVLTSGILPVFDSTRKVTYKNLPLWLKELREYPSDGTNVVKMFNDAIRAAVAYKNDSTDFMDEIMRELENFELEQADSGKSKEKEEVSDSGLDSPGNHDNKEHKDATNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGW0</accession>
    <name>A0ABY7EGW0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DYHC2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="160" mass="16984" checksum="7EE996F0414A1389" modified="2025-10-08" version="1">MCHGNGESKVLKDCLSKDDVTAVQLSKDDVTAVQLSKDDVTAVQLSTDDVTAVQLLKDDVTAVQLSKDDVTSVQLSKDDVTAVQLSKNDVTSVELSTDDVTALSKDDVTSVQLSKDDVTLVEVSTDDVTAVQLSTDDVTAVQLSKDNVTAISLQLKTVHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIU5</accession>
    <name>A0ABY7EIU5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTXA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF48">
        <property type="entry name" value="ECTOINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="257" mass="28573" checksum="6F3CF34F8750CC93" modified="2025-10-08" version="1">MDRNIREQFMKDGYLVGLDMLTEEEVEFFYRSFLAYEERMGGHVKGEYRFKTHLLLPWMHQLVTHPKILDIVTQIFGPDILCWSTDLFPKEPGTGKVCAWHQDATYVGMDPPDALTVWVALTTSDSANGCGQLEHNKTYDEKSMLLFGQEIPVEVDESTVHEAVLKPGQASVHHIMTVHASGPNTSTGRRIGIAIRYCGAYIKQNDGIGDSAMLVAGKDHGTFPLESVPCREFGPDEVEAHRKAVGAVGPEDLIAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJ80</accession>
    <name>A0ABY7EJ80_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="459" mass="52576" checksum="051DBB0210E054F3" modified="2025-10-08" version="1">MPFLYTMPFLYTLTFLYTLHLLYTLHLLHTLHLLYTMPLNDDFGADVKQERKKSSQDNKTGKCSSCNIVVNNAEASSIVVIKHQISNKKGTKLHKTSKQATCISMHWMFHASHGSDIPWPQIFQAMGQIFQTIGKIFQGMGQIIQAMGQIFQAIGQIFQGIGQIIQAMGQIFQAMGQMFQAFLGSDIQGSQLVRCPRLSMVQIFQASHGSESPGFPCVRCYRLPMSKVFQASHGSDIPGFPLVRYPRLHMGQIFQDIPGFPWIKFCTPVFHVSQIKFFTPVFHVSQIKFCTPVFHVSQIKFCTPVFCTPVFHVSQIKFCTPVFHVSQIKFCTPVFHVLQIKFCTPVFHVSQIKFCTPVFHVSQIKFFTPVFHVSQITFFTPVFHVSQIKFFTPVFHDSQITFFTLVFHDSQITFFTPFYKFVWVVMKRKFLEDDEGSGRKKKLCNVGDLSPSFSEELTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EK70</accession>
    <name>A0ABY7EK70_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4214 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_019114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046526363" description="DUF4214 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR09156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="714" mass="78148" checksum="0EC2B5115C29695E" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKB5</accession>
    <name>A0ABY7EKB5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047273399" evidence="1">
        <location>
            <begin position="23"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="215" mass="23819" checksum="4461B732935C25D7" modified="2025-10-08" version="1">MDLKCWCSVFCCMSLLLSKTDGNCARYLNIGEAKIPKGMDLATYKNTTVGTLLGEVYFGMKAPPLFVPDVNYHSLTVPVNSTHFAQLTEGDTPGTGRCASAVTYLKITTDETRFQRGPMGSAEIQVYFSSCPTKYVWGFRCSQPGGSKQNKCPLDQTYLGLYVVQNNFSVVPGIREYMSDLPFEQMAKDLCPTAACTQANNLREYKGNINDYLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELM0</accession>
    <name>A0ABY7ELM0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LRP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="150" mass="16549" checksum="41436ACF8BEA486C" modified="2025-10-08" version="1" fragment="single">QIMKWTASSKRVTVLVASVPSSRAMVFDTGIIYFADRFEHSIKLVHASRRKVYTLKSNVHDITALAIYNINKTVDGQASNPCINSNCSHFCLNTGTSSMSCDCGIGYTVTEDGSCKETDSFLLVSFTSHFRGFSLGRDDHNDVIIPIKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELV0</accession>
    <name>A0ABY7ELV0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MYLK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_036046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF101">
        <property type="entry name" value="ZWEI IG DOMAIN PROTEIN ZIG-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="38"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="137"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="235"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR10970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="394" mass="43865" checksum="25218F92FD6E7222" modified="2025-10-08" version="1" fragment="single">MYECKIQNSAGEATAAAELEVFVRPKSQTGKKSMFVPPTVDVQLEDTEFADKEKDATLVCKFHNAIDGRATWFREGREVSSWQGKATFDGRTAKLVLKDVSKRLCGTYECVVKNTGGEAKTRALVSLLDPKVKPTPPKFTVALADTSVEPGEKVVLETQVTGQPRPSLKWYKNNEELRSSQDIRMDYKDGKGRLIVNNLDPAQDAQFTCIARNIAGEEKTMASINVTGSADVREPPIFTKELNDMEVNDGDRVEMSVEVKGSPPIDIIWVHNNREIPPTDPVCRMVTKGNTHMLIIPEVFPEDSGEYVCEAYNSYGDTDTFCRLNVHEDERGSLAEGCKYNGIARMMLGHLNKLFILPNESDKTLETDEDLQTPPAFLIGPQSLHVRENEAAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EM56</accession>
    <name>A0ABY7EM56_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_035376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046054829" description="TIR domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR10300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29860" checksum="2ACE896D2A4477A7" modified="2025-10-08" version="1">MERSPSAAVFLVLYMCIATGASQLQPKFSKTPTWPHSNYYDEDGPPILLDCPLVSYDGVKLLWFKDEQRLNSVPNLEHKRQNHELFSLNPIQHIPVNEIIIGSSLGVVAVLVGVVAFVVLRHKKKQQEYDEMDWPDPDIKYDERKIEYDVFISYSSDDLKWTKDVLFSKLDAMGYNRKDVLIVIKYDQSKVPLKLTGKTFLDWNDNKVKPHFWARLFDAIGKPGDLQSDVELNNRHRLSSDDFDTTNTDDEDAKLIINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMQ6</accession>
    <name>A0ABY7EMQ6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Uridylate-specific endoribonuclease</fullName>
            <ecNumber evidence="11">4.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_035333</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ribonucleotidyl-uridine-RNA = a 5'-end dephospho-uridine-RNA + a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA</text>
            <dbReference type="Rhea" id="RHEA:67792"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17354"/>
            <dbReference type="Rhea" id="RHEA-COMP:17356"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173117"/>
            <dbReference type="ChEBI" id="CHEBI:173224"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ENDOU family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.-" evidence="11"/>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039787">
        <property type="entry name" value="ENDOU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037227">
        <property type="entry name" value="EndoU-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018998">
        <property type="entry name" value="EndoU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12439:SF42">
        <property type="entry name" value="ENDORIBONUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12439">
        <property type="entry name" value="PLACENTAL PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09412">
        <property type="entry name" value="XendoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142877">
        <property type="entry name" value="EndoU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="EndoU" evidence="12">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="EndoU" evidence="12">
        <location>
            <begin position="102"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR10257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="174" mass="19376" checksum="A4362D4EBCCDFE1C" modified="2025-10-08" version="1" fragment="single">YVNDQYYFSRPTYAALLSLLDNYNHAVGSAEHTSAQESQEVTSFLDEISKTTVMQKAHDFLSQHGNELPIYRNECFNTTMNTIYSYGSLRTHVMGALTTVPVLSTCLSGKRTTKALGSFIYGTSPEFDIAMFTVCYLTHKNQHCNFSVDGHNMEVLTYEMTHGGGGHLGTGYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENM4</accession>
    <name>A0ABY7ENM4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BUD13-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36147">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36147:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="998" mass="114749" checksum="E3E8FFCE598D88D4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENN7</accession>
    <name>A0ABY7ENN7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRADD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_035085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Death" evidence="3">
        <location>
            <begin position="865"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR10009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="953" mass="108369" checksum="2437EF1BB73A1868" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPU7</accession>
    <name>A0ABY7EPU7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ST14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_026060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042333">
        <property type="entry name" value="LRAD2/Mig-13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652:SF67">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR11880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="259" mass="28165" checksum="F7F500C753C9CFAC" modified="2025-10-08" version="1">MTKHCSKEEHVESAVAITLSKHQFKVISACLNCSFTMVTRADHVLVATLYSLGTETGSDGKCDKNRLDVYNGRKVNDSRILSGKTGICGCKFPAKSEFQSTENALTVRLFTPCNNRSTHGELVLVVSSIPNELYNRTECPGQFKCLSGECIDKNLVCDGTPACKDKSDETNCTGARNHTCAGKFECGNGKCIDKNLVCNGKNDCTDKSDEKGCHGNKHTLMFVLIGIAGLAVIVLVIILIVLCCRYCCHGYASAYRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPX2</accession>
    <name>A0ABY7EPX2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">K2012-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031440">
        <property type="entry name" value="DUF4670"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21937">
        <property type="entry name" value="CCDC66 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21937:SF5">
        <property type="entry name" value="GENE 973-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15709">
        <property type="entry name" value="DUF4670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="897"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1380" mass="155152" checksum="2A13CDC82CF1D864" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERI5</accession>
    <name>A0ABY7ERI5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HARB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_026785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="97"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR12605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="185" mass="20149" checksum="3AB7D28AC83C3731" modified="2025-10-08" version="1">MEGNKDGTEYMVLELTPVNTLNVLVGLRCLAKGAFFSEVADTHGVSRSSVCRIIHGFVDAVINNVDNIKFPVQRDDQMSVKRGFYRKCKFPNIVGAVDGTLVPILAPTANEESFVCRKGFHAINCQAVASSDLRFIDIVAKWPGSSHDAGVFDNSVLKMPTQIGGCAAIFTRKELSGANHMSQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERZ0</accession>
    <name>A0ABY7ERZ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_026913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047076739" evidence="2">
        <location>
            <begin position="25"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR12733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="278" mass="31465" checksum="97C8B6AC80410616" modified="2025-10-08" version="1">MRFFIRNGLFVISILMLDWRGHSGTPVSMLVQWLSPRSWADSFTEEKETVLSIVAMVPSGSIITIAAVKQDSVENIATFTTNSSTDDMLLGILQKYDTTENSVFVSTSLMGKNVRQTFPQHGQQMSEIVVIVCSDVTLMGPVSFILSRKLLKKTLVVKVGDFRFVDPWLDVATDADHVLFTTEHDKLMTVLQKDFLHFFKQQNGKSTKNGHIETHQPAAYQYSKPSTNMFMVEFLIGPGVLLVLIAVVVVVRWASNRNKRYRSRNVQRDEQGLEMMPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ES11</accession>
    <name>A0ABY7ES11_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TADBP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_026107</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd19609">
        <property type="entry name" value="NTD_TDP-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12321">
        <property type="entry name" value="RRM1_TDP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12322">
        <property type="entry name" value="RRM2_TDP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041105">
        <property type="entry name" value="TDP-43_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF9">
        <property type="entry name" value="TAR DNA-BINDING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18694">
        <property type="entry name" value="TDP-43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="110"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="197"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="266"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="350"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR11927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="419" mass="45993" checksum="1DEDE8A2F77283DD" modified="2025-10-08" version="1">MTTFVRVTDDESELEIEIPTEEDGVDQDGTILLTSLVAQFPGACGLKYRSETGGLRGVRLANGSLYPPGGMWGDTVYIVNFPKESKRKVDEELENPVSSKMKKVETRKTSDLIVLGLPWKSTEDDMKAYFEQFGDLVLTQVKRDPRSGQSKGFGFIKFKDYEAQLRCLAARHRIDGRWCEVNLPNSHTEQDNNPTNRKIFVARCTEDLTNEELREYFEQFGEVVDVFIPKPFRAFAFVTFADPLVAERLCGEDHIIKTASVHISSAEPKAKEQQIERQQGRNRGGNFGRGEMWDNSGSGQDAGLARGNNPVQNKSEMNAMGMEPNMNNIGMNMFSSAMLAAAQAVFQGAQNPNSSSYELGPGFGGTRDSRSGGFNNDSASGQNSYSQWGNRSGGGGGGYNNSSSSSGWGQGASGRGNWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESA7</accession>
    <name>A0ABY7ESA7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_026915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361:SF2">
        <property type="entry name" value="DUF885 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="GLR0591 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046604925" evidence="2">
        <location>
            <begin position="18"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR12735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="452" mass="51849" checksum="EA61C401DC6B3CAB" modified="2025-10-08" version="1">MFKLMISWCCIIVVCKGNVFDNLLDEFWQWRMRNNPEFASNVGNSNYTDLLEDYSIAAIDTRKEWLEDFLTRVKSSVQRNSLDAGDSVTYGPMNPISILEGIQITYGSRAELIDQIITRMKKSLEMKTTYHSVSISSVPADLDKMLVFEGNITGFPMYEPFRSKLDEKEPSSTVRAMIRAKAEQNIGYLLGQVRTLKDFISSTYIPNVRTTLGVLGLPRGKEYYRACLKWQLSTDITPQEIHDLGLERVNITYMEMENITRKAGFNGTVQEYFAQIKADDSNYERDPMFKDIKKERVDPVLHNLFEDIPPNITHMKLKMEIPALLSHETDPGHHLQDAYALTSPSIPIFRRATDFTNWNKEQAVNYMLKYTTGSRETLEREVDRYSTWPGQATSWSLRYQEVPQRDSQEWRHAPLHHGETRETVHPGYESSAQSSGGHPGLPGSGRRSSTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESW9</accession>
    <name>A0ABY7ESW9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SNAI2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_026550</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR12370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="382" mass="43413" checksum="7F0624CC629DEAFE" modified="2025-10-08" version="1">MDDKALSTENKSLDVNARDTQDKSLDLNENHVHELVAPASGEKEQKFRRVQLVVPEPKRLTSPSDSHKIDDVSKTRDMDSSLPAPGFVPYWPYQRLPWPLPVYPSIPGISAHAHMLHFPPYPGTSLPIPFLPDYFSQRNISSEYFEKLHSHLPRVPSSSLSPYSAMLFGQRSPLPHSQPSPEQKRDEGCSMKSDINTASEFSKETSPSHMSLLQNAPKTVYFDTLSTICTEKKKDKSVDAMKYQCSTCNRTYSTVSGLSKHKQFHCNQEKKEFSCKHCDKIYVSLGALKMHIRTHTLPCKCKLCGKAFSRPWLLQGHVRTHTGEKPFSCVHCLRAFADRSNLRAHLQTHSEVKKYSCRKCSKTFSRMSLLLKHEDSCARTMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETS5</accession>
    <name>A0ABY7ETS5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_027552</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="591"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="487"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR13372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="664" mass="74596" checksum="4E56B1319064DADC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EU57</accession>
    <name>A0ABY7EU57_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-binding protein NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_026947</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May play a role in mRNA degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NOB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="11">
        <location>
            <begin position="7"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="10">
        <location>
            <begin position="312"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="140"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR12767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="450" mass="50348" checksum="9183BCD3E192879B" modified="2025-10-08" version="1">MAAVKHVVLDSGAFLRNAPVQDIGETLYTINDVVGEIRDKATKQRLQVLPYTLNFREPSSEAVRAVSEFAKKTGDYRSLSAVDIRVMALTYQLEKEFCGTEHIKTQPEKQVEWKSSSKPLEKARDIAGFYVKQKNVGSSRTVSECSEQTELRSEDVPNIDPTSEHHDDSSEQEKKEVVETDNQDCKNSESEMSDKETVSENIDVDQKADDKCFESQEGDVIPEGDIGEESDSDDDDDDSGVDDDDDDDDGWITPSNIKAVKEKMGGDTVEKAVIQVGCLTTDFAMQNVLIQMGLNVVSVDGMLIKRAKSFVLRITTNVQKLFCPHCGNKTLSKVSMTVNEDGSIRYFLSRRRPQNTRGTKFRLPTPKGGKHTFNPILVEDQQLAHNRVSKKARAKNDVFDPDYVTKASPFIINDVTSRAAKLGITPQSRGGHYWDKRNPNEVRKKGTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUF8</accession>
    <name>A0ABY7EUF8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TGMH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase superfamily. Transglutaminase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050779">
        <property type="entry name" value="Transglutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023608">
        <property type="entry name" value="Transglutaminase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013808">
        <property type="entry name" value="Transglutaminase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008958">
        <property type="entry name" value="Transglutaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036238">
        <property type="entry name" value="Transglutaminase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001102">
        <property type="entry name" value="Transglutaminase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590:SF40">
        <property type="entry name" value="HEMOCYTE PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00927">
        <property type="entry name" value="Transglut_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00868">
        <property type="entry name" value="Transglut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000459">
        <property type="entry name" value="TGM_EBP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49309">
        <property type="entry name" value="Transglutaminase, two C-terminal domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00547">
        <property type="entry name" value="TRANSGLUTAMINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="2">
        <location>
            <begin position="327"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="716" mass="80806" checksum="51B83E182B69A298" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUG5</accession>
    <name>A0ABY7EUG5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="199" mass="21979" checksum="DE5779867CB7DB00" modified="2025-10-08" version="1">MTSANNQVPAPRYREFQQGTFTTFMKYVPLMPGTQQHPQQEPPKPPSQFVQPPIPMVDPYHHQPMYLQSVSQKPQQQSQPFIPFATAPVRQQQPPDQQYEQFQSPRADSAPPVTSATYDLSALLALQSPLTASQGSNIAEAAWQLSSPGNIGLNMQSPAQRPKYSSLSQVLGATSRVLASTERDNTIGGDDDNSEQEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVL5</accession>
    <name>A0ABY7EVL5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CH082-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0598 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028108">
        <property type="entry name" value="DUF4505"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31449">
        <property type="entry name" value="UPF0598 PROTEIN C8ORF82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31449:SF3">
        <property type="entry name" value="UPF0598 PROTEIN C8ORF82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14956">
        <property type="entry name" value="DUF4505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="200" mass="23047" checksum="F289B96AAC0BC5D2" modified="2025-10-08" version="1">MKEKALFKNIRPVISKIYARHVHYIQGQSPDPKTREYFYYIDHQGQLFLDDARMKNFTSCFKDRYSNEFPYLSPCGRERNYIRCDDRPIVYVHLSDNADSSEDILSYGYAGTTKLCVPFQPEKVCMLPESGRIYHPADPTVGGVGLIKSSIAIAISKYFDFGNGEDNPPTHFTWKDVKYTLNNDLITYINMDLSKAAEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXD9</accession>
    <name>A0ABY7EXD9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="98" mass="11650" checksum="D9D78A2E96204651" modified="2025-10-08" version="1">MVREQQAYQALMVREQQAYQALTVREQQANQALMVREQQAYHALTVREQQAYQPLMVREQQAYQALMVREQQAYQALMALMVREQQAYQALMVREQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXG9</accession>
    <name>A0ABY7EXG9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DD19A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="2">
        <location>
            <begin position="118"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR14035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="241" mass="24823" checksum="91A2C70C7895A550" modified="2025-10-08" version="1">MTTVGGLNLAGASGGDKPTTSTSSTTTTTAGAQATGVQATGAQGAEGGVKGATGGAGDTGATAKAGAGAAGEEEEHGVTKEDESLLHKLLHSKLVSTKADLEVLQKDPNSPLYSVKSFEALHLPTNMIAQSQSGTGKTAAFVLTMLSRVDPNLPHTQCLCLAPTYELALQIGGVTEKMAKNMLLVTRRTAHWLSEKMTKDGHAVALLSGDLDIAQRAAIINRFRDGKEKVLITTNISKNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EY15</accession>
    <name>A0ABY7EY15_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="3">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_027598</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF157">
        <property type="entry name" value="DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="180"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR13418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="401" mass="44644" checksum="8C8676FBAAC09BBC" modified="2025-10-08" version="1">MNVGAIIKMAIPMAIRKVVGEMEFITALKHNQMEVLMEILNGNDCFAILPTGYGTDQDANEAIDDGTISVIFASPEALAEEWVRQIKDVSLIVVDGGGLDVDEEKAFRKYFRYIGTLRSIFPDATVLALSATCTLKMKTQIMSNLNLSGKARVIETSPNRANIKYVVKRTPIAIEETFFWLIYKLCELKKDFPRILIYCNSIKDVCQLFNYVVTETNLMDQNVVEMYHSETPQEKKEHIVQNLGLDSQMKVVIATTALGLGVDVKNCHGVILFGPPKDVVDLLQESGRCGRNDEPSVCVIFCNRYQLNHISKEVKEVIGSVECRRRCLLKNFTSEEVVSDPAHMCCDLCVSHCNCGSCTPHPIEVLVGTFSAKAEDALVSSDSDTISYEYESDVSFDGGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZB5</accession>
    <name>A0ABY7EZB5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="322" mass="37426" checksum="9B089E62A9A81E98" modified="2025-10-08" version="1">MSAHSSRLSILENLPTGRLNEEPVAKMPQATNLAVAKEKEFSPVGPGTVFNHVLKISNATRERANLINKTEEARLQRMQRLLDKEKRFSNNVRNKVMQRASKTLTEKRALLKLLENDYKVKNFITMKQDFNPSQIEDVETARRYVIETRVFNSGFNVKSMRPEVRRQIRMLDPNHKYKTFKKKLLDDTWSKNVEIDRTINDQTFDKMLHDRKHWRDYNYPPNHPKWLATKDPLESIKSQSTSRRQSKVDEIEVVTMENAAFGQPGPENEDATKEKSIVLERRLLRRPDNACNMTLRTLGPVYFQTTTAAVPETLRSETASIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0B1</accession>
    <name>A0ABY7F0B1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="111" mass="12352" checksum="CFAE5749397DC7A1" modified="2025-10-08" version="1">MHDEDSSDKLMYFVDHWLALDKVDGSICRGLPAVRKGTPSLPVLRYVVAVTTGSWMLEWTVQIFILNLIGVDGDIGLREGTSLEPFLKVDSLGSLDKLTYSLLKPFLLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1M7</accession>
    <name>A0ABY7F1M7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="339" mass="39131" checksum="FAB20F1D2DD39595" modified="2025-10-08" version="1">MIKVNKKTRMKKNFRTLVNICLVVFVVSLIVGYTKWNMIPVNSSSSPSPITKYDLRILVIVYNRAQSMLRLLNSINEADFDGDNVKLEVWIDRSKAGVVDTLTVKTAEEFVFKHGHYEVLKHSQHVGIYGQWFATWKARVNSSEIAVILEDDLIVSPHFYKYLKLVHNKYDNVPDINGFSLQGISIKHAIGYSSQTLEAPESCLVYLYPVLGTWGFSPCRDNWIHFLEWFSQVIQNKTFQPYVPGNVVTAWYKIFQAQGRADGEQSIYHIYHSWKFKEYTLYPNFKGHKGLTTNWLEAGLHYSGNASKPSNELLKEWKSDYENLPDQPKHLNLKGVVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1W1</accession>
    <name>A0ABY7F1W1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SYT3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_005177</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00276">
        <property type="entry name" value="C2B_Synaptotagmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="159"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="308"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR15072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="447" mass="50732" checksum="8FA0863749D0B7C8" modified="2025-10-08" version="1">MAAVGNPTLAPNVEYIVITFWDKIYIVCGAAALLLLLLLCMLCILCPECFCRCCVEDEKKRQFQRDSDKSASQRSNASKGSYGSTDSDFMYGSGDIKDSGPIRWMPLDVIREQTTDWSSDASSGQDVISLDRNKKRIGFLPNGSQNGDVHPPGTPPVLEKGEIHFALSYVQTEEKLVIKINEVKDVVLTENQQLISPYVRVCLYRSPKQFFTFRDGGKTEKNITNLEKELKTRMKRPSDVLAYKETFEIPMDLESLKSMTINILLCDMDKFSRHVTLGEISVNLKKANLLNIQEREYSEDFSEPNKENLGTLTLGTSYLPTSEKLYLTVESMKDLRIIDKNSGTTDACVKIYLMYEGKQLKRVKTTVRKNDTNPVFNESFSFDVPQTEIEKVYFSLVICHYNGEKKGTKLIGRIYLGTNFGPEARDFWGSMIQNPRKKIVKTFDISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1Y0</accession>
    <name>A0ABY7F1Y0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="522" mass="59021" checksum="508484B9DF4B31A1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4A0</accession>
    <name>A0ABY7F4A0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_005638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR15533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="273" mass="31208" checksum="C768D9872066F312" modified="2025-10-08" version="1">MEFITSSRGAPKLCFDSFTYTKKKSSKTTITWECSQRRTLECKGAVITDSPATEIRSSREHNHEKDDSHGCFYHLTQSTWRYLQGEGLQATYREDPDIRQFCGMLDGLAFLPEDQVKEGMAYLKSQTTEVLEPVVDYFDRNYVNGPFRSQTGGLIFRRTQPRFEPATWNVNTATLNDEARTNNVCEAWNNGFRCLVGHVNPSLWTVISCFEKDAAMVEAEILRVQRGQPSKKPARKGTVRYQKTLKTLCQQLSNGQKTVEEFLQAIGGHIRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5W7</accession>
    <name>A0ABY7F5W7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR17563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="8171" checksum="EA35B996F20F78BA" modified="2025-10-08" version="1">MTSVLCVFFCGLLSDDHRVDDDGDGFLDENPDYSGTDWCKIDRLIRACLGTKLVEWQWHPLRREECPRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F736</accession>
    <name>A0ABY7F736_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="857" mass="91352" checksum="2BF8FC68579160C4" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7T0</accession>
    <name>A0ABY7F7T0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="370" mass="43020" checksum="AD0EB2628ECACCB7" modified="2025-10-08" version="1">MVCQNYCDGAELFLDILTKEEKEALLTKKMEAIRKKNDVIRIRHEEIQADKWSSSPNHKVIETGPGKPIHDVNSRASQSPKKDTRPINGEEIRQRPDRDRSERSPEKRPQKPATGRGKQLARMSKEKLKAQDIRISRSKSDVGQPRSVSFQGDANQPLDRQRSRDSQGSDGSGPRQHEFDSRIFRRHVDKQVTFEDQQPNSAPRMQHSHNHSQPYQRPNQRSPRRNWDNNDENQFPPEFKNNPLLRSSSFGDQDRRRNWDQHDRRGNNHHDNRGDRGQNQGYRNSNENFGNNNRGNFGQHDRREFQRNGFGRGNRQDYDRRDNNRDSHEHMAAGMIIEIIGSIETGEIIIEMPGSSTGRKTGMRRSPDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8M5</accession>
    <name>A0ABY7F8M5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_031627</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="658"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="658"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="692"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR17033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="797" mass="90008" checksum="6B363BA818F717BA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8X4</accession>
    <name>A0ABY7F8X4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_032066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="39"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="7">
        <location>
            <begin position="700"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR17472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="863" mass="95239" checksum="FA142BD5D5CAA8D8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBG4</accession>
    <name>A0ABY7FBG4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_001278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="48052" checksum="76A59DCF4707309F" modified="2025-10-08" version="1">MEYYEQTKQWSDTANLVTSQSDVMATPTAEVKRVRFSVEEDRDSHNSDEAFEGQWDFLKYLLTLREEINVNSVVDSLVQKGVISADAGSDVMRQGTPRAQVELCVQEVMKGSGPAYRSLCETLQEHGYTNILLREHWSQRDSVVDGFSVQGKKMALSALSRDAKASQREFSVIVERQQELEKQLVQVMKSLDRAKDMLIAERQEKLGLREQLRSRDEELVTRLQIENEQLRKGVRERHELESELRERNGELGRLRDQLTEQEAKMRSQEEKIVSKLAMIERVVGEHKTLVDGQEKLTKKINLQANDIIQLHEEKDEAASQMAAQQRQLNFQQAQIGMIQEQMQRLEGSLGGGGGGGGAGGTYGGSSSRAESLPPLPSTPGNDGRNSRYIHALSKSMNLNRPFNPYGKLENSKNMLWRGDSSGKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEV9</accession>
    <name>A0ABY7FEV9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_001252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="272" mass="30753" checksum="438B576EF6044BDE" modified="2025-10-08" version="1">MATKLSDSVLNSGDFEYDFPCTECQERALNSEAIYYCENCTRQFCGLCIKKHDQFYRGHQILGLKKRDAWGKVMATDKQYSLVENKHFKVKLKHDKNSCSISGITVLPGGEIVIADSKNRNLMLLSASYTVVGHARVPVGPWEICAVSDKQVAVGTVGWDIQFFHVQNKQLKMDRKIQMEHKCYYVSYSEGHLYVSSGLTVYQYTLAGQRVREIYKTDGWTVWGLDISVVRVRNDSNISANSLELIPESTEFSTKVLAKLKTNNPPSANNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEW3</accession>
    <name>A0ABY7FEW3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SERA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051760">
        <property type="entry name" value="KMT5A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46167">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46167:SF1">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="297" mass="33728" checksum="8B7614871CF90C82" modified="2025-10-08" version="1">MSKNDHKGDNRTTRLISRNETRKKQENVAADCIDSGEDLKDFVIEHIPPKEREGEEREEREPSVFRYFFQYKRKGMDATSELDVGPRLGRLVNHGGKGKNCVMKTLEFNKRPYLCLFAAKDIPQELVAATDNLENMLEAQTTESENMLEAQTTDNLKNMLEAQTTDNLENMLEAQTTDNLENMQEAQTTDKLDNTLEAQTTDNLENMLEAQTTDNLENMLEAQTTDNLENMQEAQTTDNLDEMLEAQTTDNLENMQEAQTTDNLDNTGGPDYRQSGEHAGGRDYRQSGEHAGGPDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHF8</accession>
    <name>A0ABY7FHF8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_015592</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd17389">
        <property type="entry name" value="MFS_MFSD10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF31">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="32"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR21618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="420" mass="45269" checksum="24F099B938CD3837" modified="2025-10-08" version="1">MVVTRSQNNGAAVPQSEGKSGDTTLSKGERKTLTVVFISLVIDLLSFTVILPLLPSLLDYYGSKEDSLYEGLKQSVSSFRLIGSLFSLLQFIASPVIGAASDVYGRKPLLILTMSGVAVSYGIWAVSQNFGLFVLARVVGGIFKGNISLSTAVVTDALPQHKRGKGMAVIGIAFSVGFVFGPLIGAVFSRWARAQQGEFYVFPALFALALAVIDVIYVAVVFKETLPEHRRANSISNISSVQKIGLVYFLYLFFYSGLEFTLTFLTHNRLDYDSMQQGKMFFFIGSLMAIVQGGYVRRVPPGKEAKLAGIGILLLIPSFILMAFAHSALILYLGLTLFSFASATVVPSLTTMVSAFGGNDQKGTVMGIFRALGALARALGPMFASTVYWSFGSHICYIIGGVMLIVPYLILKAKPSGKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKK3</accession>
    <name>A0ABY7FKK3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="420" mass="46628" checksum="DB9A8FA53D57E7FF" modified="2025-10-08" version="1">MTTSYAKLLSTTYDAIEFRMLSKTNLELLVGKNKPRTAADRRRVGVPGASPHIQTGHNNSSLLADRRRVGVPGASPHTQTGHNNSSLLVDRRRVGVPGASPHIHTGHNNSSLLADRRRVGVPGASPHIQTGHNNSSLLEYRRRVGLPGASPHIQTGHNNSSLLADRRRLGVPGASPHIQTGHNNSSLLADRRRVGVPGASPHIQTACSVGAYKSEDEQQEILEDLRDVLKDHLVLKSEVDYSDADELRDGRTLVNASGEAIQEPESDEDLLYYDQEDDEDDLEKDLITRLLPYVGQDKRGSLTEVIAETFEGLKAELKNLPGNYEQFRFFKLKSIFRRLYIQKRKLEAEAQKERPEAGTQGLLESVLKFRRNVLDIMRKSVNGFCKRNVLGSCGNSCGCDFLKCVPSSSRPGRKYCRIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLA2</accession>
    <name>A0ABY7FLA2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GSOX1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_015623</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR21649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="184" mass="20738" checksum="8B2B888F4160FC88" modified="2025-10-08" version="1" fragment="single">FLAKHAASKRVCVIGAGPAGMSTLIHFAKLPEMPDVVCYEKQDTCGGLWNFTWITGVDQCGELCHSGIPKECCEFIDYTFQKHFGHDIGTSFPSREMMLVYLKGNVKLSFNQRNGRWTNNAGRDLEQYITYSTVVRSVIHTEKTEMFTVTVNDLRTGAIRTEQFTHVVIACGILTSQMLLNFWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FP13</accession>
    <name>A0ABY7FP13_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NFIL3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_037541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd14694">
        <property type="entry name" value="bZIP_NFIL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047229">
        <property type="entry name" value="NFIL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047106">
        <property type="entry name" value="NFIL3-like_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15284:SF0">
        <property type="entry name" value="GH23983P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15284">
        <property type="entry name" value="NUCLEAR FACTOR INTERLEUKIN-3-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="141"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="491"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="554"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR23872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="599" mass="67871" checksum="7DB939204E4A9EBF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FP89</accession>
    <name>A0ABY7FP89_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CSMD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_037724</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF4">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="53"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="110"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR24055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="168" mass="17678" checksum="42D0076B70CD1A48" modified="2025-10-08" version="1" fragment="single">MISVPNGMVNTSLGTTIGSNAKIECNAGYFVNGSSWIVCTVEGWDGNPECFKQDCGDLLVSNGHVTYFDGTLFGDVAQVVCDTGFSIQGNATVTCKGGPAWSSIPSCDIKDCGSLEPPESGVVTVDLTTYNSTAEFKCDDAYLLFGDAVLVCLSDGKWSSEPPTCLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FS34</accession>
    <name>A0ABY7FS34_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA 3'-5' helicase Q1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_038494</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="204"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR24825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="411" mass="46135" checksum="B457297D25261B33" modified="2025-10-08" version="1" fragment="single">EDVFLCKKTGGGKSICYQAYQPCWTNLHGDVEKCQVLVVCPLLSIMKEQCECLSAAGFSATYIGTDRDDEEALLNGDFQFVYTSPEHILGVSKWNGMFRSTTSFQLLVMKHIQFFTGGSSEKADIPFRPWFSKLGKIRSLIDCPVLLITATANKAARMKLQSMFCMKSCFEIIDNPDLENIKLFVTKVKSTIPLSEIFFFIIQKVKAEKDTCERYIIFCQSIKSCSEIFTMFRLQLGLEIHYIEMFHSNTSDEVKENVKKNMNDINGSIRILAATSAAGMGVNFQGVKHVVNCGPPADMDSFVQQYGRAGRDGSFATGLLIYNAKQCKKNDMDMKNYLGNTGLCRRQQILNAYNAKLAPICKHLCCDLYSILCNCDDKSCSLFNHPNFESTLPSFSSDSPDSSNSDSDWSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUE8</accession>
    <name>A0ABY7FUE8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TLC4B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_036495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="6">
        <location>
            <begin position="63"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR22826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="164" mass="19345" checksum="0E728DCA8D40D1A4" modified="2025-10-08" version="1">MSIQERYRAQELQYDPSYLLAGGVASFLLNILLFRFVSPSVSACLSPAYTRLPRHVRAEWDDRWYFDKLEYSRSRPLVVLNGFLMVATFFLFRMCAMPVYWFQVWQVAGSEAVTRLGHIRAIMFVPTFVLDVLNTFWFYKMCRGFIKAIRTLKTPLKDMERKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FV96</accession>
    <name>A0ABY7FV96_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR23111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="183" mass="21010" checksum="4F156D38C9C6E4CE" modified="2025-10-08" version="1">MARATGLASRMMFSAINRGQEEREEEEARIAYGDTGEDEPDMSSHGEPESVTKVFAKRGWKMLKRQVNENAMEHHTQSTKLNWVMLQHTVKQMTNTEKTRQDLYERYGIVPTKLDDGTFVCENRMLSERARSQMYGRTVDGREYMRPSSYQPNAARLRSRSQLSSYSTTSQKKPRGNSKSGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FV98</accession>
    <name>A0ABY7FV98_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LRIG3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_011251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045150838" evidence="4">
        <location>
            <begin position="30"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR25547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="538" mass="60422" checksum="8699A05B0DC149C6" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWQ7</accession>
    <name>A0ABY7FWQ7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_011776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037760">
        <property type="entry name" value="SMKR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37932">
        <property type="entry name" value="SMALL LYSINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37932:SF1">
        <property type="entry name" value="SMALL LYSINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR26072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="257" mass="28478" checksum="A8519DA3D03C0C96" modified="2025-10-08" version="1">MEQLTKVIDGTEVDTGDVTQFTDESLIKKVYKVSDEELNCGSLTDALVSKIASKEFVTVCIVQGGHSRYPVLLLRLPLIPIFIRLFWPVDVTESEKWLLLHGTPQGKRTENMYPLVCYKVRLELCRETTQITEVRPRVAMGYQVLRQKLPLLDSVREIQLQKSNNPKKSGKKGKKSGKKSGKKSGKKGGKKSAKGSAKSVKGEKTEVDILSQPAMENLYYIAHDAPQALDMRGFGWEGGGGGGKKGKKGKKGKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FY49</accession>
    <name>A0ABY7FY49_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Reelin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_011798</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Extracellular matrix serine protease secreted by pioneer neurons that plays a role in layering of neurons in the cerebral cortex and cerebellum by coordinating cell positioning during neurodevelopment. Regulates microtubule function in neurons and neuronal migration. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Oligomer of disulfide-linked homodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the reelin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034968">
        <property type="entry name" value="Reelin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049419">
        <property type="entry name" value="Reelin_subrepeat-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11841">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11841:SF1">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21471">
        <property type="entry name" value="Reelin_subrepeat-B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR26094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="206" mass="23186" checksum="91E18D3D27A91F81" modified="2025-10-08" version="1">MLEFVLKIGSNELTHRCTQPSSPNEGIILDYSTDNEMTWSLLKVVEPKLYNGSKERIVIQLPHEAKSDRTIFRWWQPLGYGGMTKAEWGLDSVTIGVNETNLDGFQDDFAGMMPDMFTWFQTESAVPRITCNSKGNALEKEVCRNVGLPSTPSTFLQFDIAMGCDSLYNTVYGVMLEYSTNMGKDWDTVVSECAPPILNAMDTIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYT3</accession>
    <name>A0ABY7FYT3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLXB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF44">
        <property type="entry name" value="PLEXIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="204" mass="22246" checksum="DC5AAE01DA8AF1EF" modified="2025-10-08" version="1">MIYPEKGFLSGGTVLTVKGKYLNNANAGTVRLVEQCVIDTNSSAQVLCRVPPASKGIIQELNAKASSSNKRKKRSAQCVECVTVTIIVKLDGVEHSFNISYFHDPSISKFDQGVLLYQSDQQYLEIKGENLNLVAAKHDINITIGIDVCNVVELEGDFMRCKAPSSQPQPGIPGATLPEVNVCTLAELIVISDNRKHPYNFGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYZ6</accession>
    <name>A0ABY7FYZ6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kelch domain-containing protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_012208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KLHDC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052125">
        <property type="entry name" value="KLHDC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46428">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46428:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR26504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="372" mass="42464" checksum="7F82D187F0A24064" modified="2025-10-08" version="1">MLKNATRPTCFHTQSESNDLIIPRSGHRVLVDSQFLYSWGGFNSDLWDVENDEHTRFPLLKEMLQYEMVTDTWRKLEMEGEFPTGLASHVVFKLHRHILHTGGSGVPFGGSNSNAIYDFNLDTLQWKCIVQEQDLSEEKEAAAPKYGQALAQIDNYMYIVGGTSGFTYDMDINRLNLTDLTWEHLEPRSKYVPSERYRHEVVHYEGNLYLFGGGTAGIEYQLKEIDVFHIEMRVWEKAPTVPYQDIDGGKSLYPAGRKCHSCHLLADSVYVIGGLGGGRIQQKIWRLHLPSLQWTKLDFSLPKPDGCLFVFGGVTKIDTERTNDLQCVWLAIPSLRTMSWSVVWSCLDKTRLAETRSRLLQLGVPADLLQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1I8</accession>
    <name>A0ABY7G1I8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LSM5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_014022</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR28318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="93" mass="10526" checksum="B4153B74CF788117" modified="2025-10-08" version="1" fragment="single">MTTFTNPSQLLPLELVDKCIGSRIHIIMKNDKEIVGILLGFDDYNSQDSLCIKLYEVCIDRLVGALPRGLADGERPRRCIVVYEDVDGYTFTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G216</accession>
    <name>A0ABY7G216_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ASL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="1">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="179" mass="20973" checksum="04F500EE697F3503" modified="2025-10-08" version="1">MARLYDWHKNLTFFTENVVNNCPGYNVQMPEYVPMIWRKWTLGVDPGIPAGTKYILAYNEPDRADQANLTPQQAAEFWPNIEQLVNGTDIKLDPVPASSDFVWLDQFFENCSNCKVDYLAAHFYSCNENDILGYINRLSRRYKNRKVWLTEFACPTAEYSETFMANMLKRLEKNTNVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G248</accession>
    <name>A0ABY7G248_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="124" mass="14186" checksum="C9C13D59061D4153" modified="2025-10-08" version="1">METADVYAHGKSATLKTANSSSSATDEEAKGFSVIREEQHTDRHCKYKRIKGQGCVIHVRICKCGSEKYPDKKHLIARQSFSEPDGVEVHFSTSCQWQRSKVSYFGKTSYMMFPYHTDWNGREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2I6</accession>
    <name>A0ABY7G2I6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">USP9X-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_013173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021905">
        <property type="entry name" value="DUF3517"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12030">
        <property type="entry name" value="DUF3517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3517" evidence="2">
        <location>
            <begin position="97"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="496"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR27469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="628" mass="70350" checksum="EDC5295C69BEB062" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G474</accession>
    <name>A0ABY7G474_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">QRFPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_002533</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR28965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd14993">
        <property type="entry name" value="7tmA_CCKR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="80"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR28965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="396" mass="45485" checksum="8155F16D8843D6DB" modified="2025-10-08" version="1">MFVNRTNFKMNASQGSSPAYSSGLITSYNASHYYYSGDYNTFDTSLYLSNLDVDLYLDLSPLNVALIVLYGFIFLSGLFGNIIVIISIIRFKSLRTLTNYFLLNLTIGDILVIIVCIPLTLGSTIYKKWVYGEVLCKLFPFLQGTAVSVSVLSLLFITGSRYVAIYRPLVSKLVFSKRNVRIMIFFIWCVSFSAMLPLLVVNKVRHEIELEIFESIICEEKWNRLDDKFIFTVFIFIILFVCPFILMTICYIVIGYTLWYSRKCLVDESSCQKNKNQIILRQRRRTVKMLVCILVTFGICWLPYYAVNFWIDANIGDASKTEMMSAVYTYMFPLVVLLGLSNSAVNPVFYYILCRGFRRSFNTILCSGLLKRGEQLLRQSMKGKHTISESVDTAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G532</accession>
    <name>A0ABY7G532_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_014183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046604943" evidence="2">
        <location>
            <begin position="23"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR28479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="172" mass="18965" checksum="1E870BA280FA77FA" modified="2025-10-08" version="1">MEDQKLSVLLLVCVSAVHTSLAQWPLGPDFYNSMDALRTNLNTMNTNMETNMNTMNTNLENNLNTMNTNLENNLNTMNTNLEMNLNNMASRLQIIGNTIRINGQAMVEDDKARAANGVAFAGGLVFNSGNGGLGYAYNSSDGSYTQYAMDGGSPPHGYMYHTWQFGTSIRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8D2</accession>
    <name>A0ABY7G8D2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PEG3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_033215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053300">
        <property type="entry name" value="Homeobox-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45795">
        <property type="entry name" value="EARLY GAMETOCYTE ENRICHED PHOSPHOPROTEIN EGXP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45795:SF1">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="404" mass="44480" checksum="8FF34668E209349C" modified="2025-10-08" version="1">MSQTSYINPVSQTSYINPVSQTSDINPVSQTSYINPVSQTSDINPVSQTSYINPVSQTSYINPVAQISDINPVSQSSDINPVSQTSYINPVSQTSYINPVDQTSYINPVSQTSDIDPVSQTSYINPVSQIYDINPVSQTSYMNPMSQTSYINPVSQIYDINPVSQTSYINPMSQTSYINPVSHTTYIYPTSYINPVSQTSDINPVSQTSYINPVSQTSYINPVYQTSYINPVSQTSDINPVSQTSYINPVSQIYDINPVSQTSYMNPMSQTSYINPVSQIYDINPVSQTSYFNRMSQTSYINPVSQTSYINPVSQTSDINPVSQTSYINPVSQTSYINPVAQISDINPVSQSSDINPVSQTSYINPVAQISDINPVSHASIIIFMFQSSDIKPVSQTSDINTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8J2</accession>
    <name>A0ABY7G8J2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HARB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_033272</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF227">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="48"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR30730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="212" mass="23544" checksum="B0BFF441758AF39B" modified="2025-10-08" version="1">MSRHLYEVVAAINNKMKNIRFPTTLEERREASLGFYTLCGIPRVLGAVDGTLVPIIAPHDNEEVYVCRKGYHALNIQAVVNSNMRFNDVVSRWPGSANDAGNFDNCGLKRHLELNDVGMLLGDSGYPLRHYLMTPVLRPQGRQQTAYNGRVVVERAFGLLKSRFRPACANARNSSETGRSRYGPAATCCTSTKPQRGASSEHSYKSILNLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8U7</accession>
    <name>A0ABY7G8U7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="163" mass="17795" checksum="6AC5157890D50FE4" modified="2025-10-08" version="1">MKFYEVPSCTPVYDTWHAASIIQVCHTTSELRRTPSPSALMEYAMPSNCSLLLKLCRALAGFFSIVIITLVNVNNNFLRINIGSVDSSNDANIYNGAELKKVLESLKILFNLPGEKSLRGGDVPAPYCILGKCCWGKSHIPLGGHVTPSLPSSNVSFSQYNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9Y9</accession>
    <name>A0ABY7G9Y9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_033487</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF14">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="4">
        <location>
            <begin position="47"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="4">
        <location>
            <begin position="114"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="4">
        <location>
            <begin position="176"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="4">
        <location>
            <begin position="238"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="4">
        <location>
            <begin position="300"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="4">
        <location>
            <begin position="348"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="4">
        <location>
            <begin position="404"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="4">
        <location>
            <begin position="457"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="597"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="565"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="565"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR30945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1034" mass="118522" checksum="0DE153D81460D42C" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D9L8</accession>
    <name>A0ABY7D9L8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="57629" checksum="CF52C43626A57A3B" modified="2025-10-08" version="1">MSFEIFLQTKTNSKPEYEINENSSDEEFHPPLPKKPAFASPLSVRLNIPSTPKSHSRCFICKRPGPKLIVVPSEARFAAFVQCNVIIKSGTRWCPVHMNESLIKDEALKSVKAAESAYVNRATVLELLNKLRESCKKSNRRFDFTTLNNEEYVDLTGLSKAAFGDICYCIEGHIRNTPVRDVHTTFDISKSSIRRAITSTRQTLTEHFVPHTFGLNHISRQEVIDKHTRQLAHSLLLVTLEKAHTEPKFISRRVRITTSKAGPTACARGVIVSTTGYNRTVVVLYLSDGNNNDAKIHSHILNTNVEDLKPLLNLATYVWILEYNPRCLYFYQKVRNSFKPRIRWVVESANARLKRWKFLDRVLPNSQVPCIDDLVKIICAVCIKYLPPLSSSTDDDARQAQQMLQLVKQGNSLQAEIEEGNLEKSRAVWVPVDDTELEGFPRRTEDTLRTLTCGENLEGDEDIRVHKENSGRLQSRHISAKQYTIWLKFNTVEIHGWYLNADLGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DE94</accession>
    <name>A0ABY7DE94_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="122" mass="13843" checksum="BD66FD0EE15AA4A1" modified="2025-10-08" version="1" fragment="single">MKLIRRFVVKALQHNVHCRAEHIPGSHNILADYFYVTSVKNILLQQSASYLIFCGCDTTLYKGHSFRIGAATSAAEQGLSESQIQRWKSRLIRNTSAYQCHRAKRLHALPGGNFHFGQQTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DF95</accession>
    <name>A0ABY7DF95_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ93695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40351" checksum="F72C1665E12A5386" modified="2025-10-08" version="1">MQLLSMKRGQRKSVCLQRVLEQSFEPKQTSSRHQKSSGVEPNPGPATARGRGGQRCAASTTATDPLSVSTAGAMGGPDFQQQPSARGDRATRRSELPLSQTSVSTWLQTGNSRDVESLAGFSEDVHGDTDVRDSEPGSELTMTEILLEIRRDVKNMDRKFDTLKKSVADLKKENLVLKEHNIKLSAEVNTLTKKMSIVEESVTSSDLRSEQIEMQLKKNNLKLFNVAESPNEIAAELDDNVRKLVRDDLGIDNSNMSFEDMHRLPGKQSPRPVHVHFANYIDRKTVLSKFRTKRKSTNLPCRISEDLPQRISKARTDLFPFFKECIDSGKLAYFKLDKLVVDGKMYTYCKDSKSPILASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHW4</accession>
    <name>A0ABY7DHW4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="13">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_029208</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="13"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF107">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="15">
        <location>
            <begin position="106"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAQ96518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="695" mass="76888" checksum="582FF3E73F55CDA3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DK48</accession>
    <name>A0ABY7DK48_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ICEN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="entry name" value="Serralysin-like metalloprotease, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="Adhesin YadA, collagen-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="337" mass="35492" checksum="AE43D1CA75DA7A99" modified="2025-10-08" version="1">MLYGDGSTDGHDNDMLYGGGSNDGHDNDMLYGGGSNDGHDNDMLYGGGSNDGHDNDMLYGGGSNDGHDNDMLYGDGINDGHDNDMFYGDGSNDGHDNDMLYGDRSADGHDNDMLYGDGSTDGHDNDMLYGGGSNDGHDNDMLYGDGSTVRHDNDMLYGDGSTDGHDNDMLYGDGSTVGHDNDMLYGDGSTDGHDNDMLYGDGSTVGHDNDMLNGYGSTDGHDNDMLYGDGSTDGHGNDMLYGDGSTDGHDNDIIYGDVITDEHESDMLYGDGSTDGHDNDMLYCVGSTPDTTITCYTVTGAPTDTTMACYTVTGALTDTTMACYTVTGAPTDTTMTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DK97</accession>
    <name>A0ABY7DK97_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="20">PK1L2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MAR_029785</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">MELC-2E11</strain>
            <tissue evidence="20">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF194">
        <property type="entry name" value="LOCATION OF VULVA DEFECTIVE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2023"/>
            <end position="2041"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2167"/>
            <end position="2188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2208"/>
            <end position="2231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2344"/>
            <end position="2366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2386"/>
            <end position="2412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2485"/>
            <end position="2504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2733"/>
            <end position="2753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2773"/>
            <end position="2791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2825"/>
            <end position="2842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2862"/>
            <end position="2884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2920"/>
            <end position="2946"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="17">
        <location>
            <begin position="137"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="17">
        <location>
            <begin position="545"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="19">
        <location>
            <begin position="1875"/>
            <end position="2014"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="18">
        <location>
            <begin position="2033"/>
            <end position="2154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1878"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1923"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3030"/>
            <end position="3057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="WAQ97095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="3057" mass="344652" checksum="C9DD896B0F06CDF8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKC1</accession>
    <name>A0ABY7DKC1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F227A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_028140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM227 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029417">
        <property type="entry name" value="FAM227"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33560:SF1">
        <property type="entry name" value="PROTEIN FAM227A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33560">
        <property type="entry name" value="PROTEIN FAM227B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14922">
        <property type="entry name" value="FWWh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ95450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="350" mass="39953" checksum="F05F6C3E9E7CFB04" modified="2025-10-08" version="1">MKNISRYYKRILDKREQKEMNRFAGYYTLKQTFLPGRSERVRNISKISLSPSKNQVKKDSGKPKFVEDMFWYLFLDKFQSSQNAQIKLFNRAAFNYVKLMLFVKNPAYRDVFFNDYPSLMSQSLYTAFCYCFPDSYRQFGEEFKEDLVALVYGWIAANTSINFDFLDSLISTNISRYASSASVSQSASNMSTHSRRGKGRNRKLSQSDRSGKGSGSSKVPSSSASSSSQEGKIPGKDELCDLVIVEQTESTKKSSKEKKSVDPRKLVEALTPIRETTFEDYESQADQGETQSEHSHPACKGADTVKSVYNLYGQSPLVAHFLRVKNLTRESGQTFHVQRTEQENLPPYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DM01</accession>
    <name>A0ABY7DM01_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UBCD4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_023087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd14391">
        <property type="entry name" value="UBA_II_E2_UBCD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042614">
        <property type="entry name" value="UBCD4_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="161"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ98714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="200" mass="22484" checksum="AF7423788C58A0D1" modified="2025-10-08" version="1">MANIAEQRIRREFKEVVKSEEVARCHIKVELVNDNYTELRGEIIGPPDTAYEGGTFILEIKIPDTYPFNPPKVKFSTKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVAKQYKENLPIFQQTARHWTSAYAGGPNKEKELEQKVEQVKNMGFDEHKARVALSSCNWDAERATESLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMN3</accession>
    <name>A0ABY7DMN3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">p-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_023327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd01116">
        <property type="entry name" value="P_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051475">
        <property type="entry name" value="Diverse_Ion_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568:SF1">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="7">
        <location>
            <begin position="99"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ98954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="587" mass="66061" checksum="CDBDDAC37FDC671C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPW6</accession>
    <name>A0ABY7DPW6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="105" mass="11527" checksum="4C24DDFD0E06ADA9" modified="2025-10-08" version="1">MKDFVNDVIENLDIGPSKTRIGLITFSRYPILRIALNSGYGDGRSYRTVGSRITMFAIGIGTYINPDELEAIASVPVDRYMYVVSNFNALTRSVAGITARTCNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQ05</accession>
    <name>A0ABY7DQ05_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_022813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ98440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="184" mass="21239" checksum="9762F8C0DA9DD347" modified="2025-10-08" version="1">MQPVAYQPSPLIKKKGSSVYMSDDNSVTYREECTEEKPKNDVSGNGRHINVTKRALNDDLVGSRVAKILYFVDKAFMNEYEFMFKDKGEKAMMFCYRFLPLGEDDYEATKVIVQDFLTLLTNQVTVSYQSLRQYNKRLYRGEAFYDQDVAIQLVGIEYPPEICYAETCQSKKICNTKPCVCKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRB5</accession>
    <name>A0ABY7DRB5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_023011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ98638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="159" mass="18616" checksum="1FC1352993C3BB3B" modified="2025-10-08" version="1">MNARAHVFELVHYKQAGSYSVGTLGFADEDCDFIDFTYISLEFYQRKRGRWLFQAECIPWEVWTVKLDVITLNTEHERQIFRERVGEAVAEKVLYIAEIMNRHEYLPKMPNNSEVDLVFDTSYTDVQPYLHRITHQINGPSSSSVSTTMRKFLKDTLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRP5</accession>
    <name>A0ABY7DRP5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="61" mass="6944" checksum="0D970C8449647EC6" modified="2025-10-08" version="1">MKDQTSVLGDEDGVFAEWQKPRQSIGRRRKKSNLQDLAAHLNMARDGLPVPYTLCKVRNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRU2</accession>
    <name>A0ABY7DRU2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">GLRA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_024797</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="92"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR00425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="233" mass="26943" checksum="6C977E51F2E3A0C5" modified="2025-10-08" version="1">MNLRKYPLDHQFCNIMMESYGYTTDNLVFEWNPIPLEIDRSLSLAQFDIGEIETRRCDKSYIGDTDGNTVNFTCIMMQFELIRNFGYYITQIYIPSILIVILSWVSFWLDIDAVPARISLGLLTVLTMTTQSAGARSSLPKFAFVNVNTRVGKRHQQTKKMQTNLAKEADGEQEDNTPNEGRLNHWNVFASSRKNARIMDRFSRVAFPVAFIVFNIVYWSVYTFWQPSKSDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DT79</accession>
    <name>A0ABY7DT79_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GNRR2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_024461</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF59">
        <property type="entry name" value="ADIPOKINETIC HORMONE RECEPTOR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR00089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="158" mass="18352" checksum="2BC644194C9E6B6F" modified="2025-10-08" version="1" fragment="single">MNDFRFKQDLAGKESVIFHEEAHPAYPWFRQCITFNFFPTPAHELVYNLFTMVAMYGLPLVIISLSYGLILREISKKTRQSKEEMLDLNCPQSSGRLRRSAVGNIERARSRTLKMTIWEFLYFVGHRTTESARELDSKIQSSLFIFAVSNSCVNPIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUW3</accession>
    <name>A0ABY7DUW3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_024843</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="6">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0801">TPQ</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="9">
        <location>
            <begin position="134"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="8">
        <location>
            <begin position="326"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR00471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="432" mass="50345" checksum="C5A4A2D1E254F8D3" modified="2025-10-08" version="1" fragment="single">MFNNITMSTKNKCKSSKDDNKGIFHEYFESQEQIKAEEEGSEEKWRPRGIWVLLTWLFALTSLVLFITLMCMVALNKHPGNRYPAPCEQNTQHDRSKGRNRRYLECSVPIKTNGSDVFEELTETEIYEVVEFLNSQPDLKLESPDKLSIESNCIHSIEMKLPDKENVLAYLSGRGKKPERMATVYLFRGADDPPTVDEYKVGGIGDKIYAHLLKTDRRQTQVPFIYRPFSTAEFFSIFRYILPQITKRAGHVLKESYDAMPMKCGDKCLKISMAPVASSFIPAGKRKSWFWFQHDIEFSSVRPLDFQFLVDTTSVRPTEWTVEQIWYANQMFPNLTVFLQEYERATYKYNFDTPKVHVFSNYGHISSLGNPRGYRVEIHKMTKQLHPEGYGFEPSVSWARYQMAVTRYRPEEERSSSVFTMWDARSPAVNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DV12</accession>
    <name>A0ABY7DV12_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="49" mass="5478" checksum="04D5779E9CD5DD7F" modified="2025-10-08" version="1">MEGKSVVLIKLSSFSARIQQHKTLKVYLTVNPTLMSTWLSSIQTLSVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DW99</accession>
    <name>A0ABY7DW99_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="163" mass="18722" checksum="679480C02A9E9254" modified="2025-10-08" version="1">MYDAVRDTNKVYDAVRDTDKVYVAVRDTNKVRIAVRDTNKVYDAVRDTDKVYVAVRDTNKVYDAVRDTNKVHVDVRDTNKMYDAVRDTNAVRVAVRDINNVYDAVRVAVRDTNKVCVAVRDTNKMRVAVRDTNKVYDAVRDTNAVRVAVRDINKVYDAVRDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZM6</accession>
    <name>A0ABY7DZM6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UBE2T-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_009760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd23805">
        <property type="entry name" value="UBCc_UBE2T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="2"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR03202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="170" mass="19858" checksum="26932773DFF1CECD" modified="2025-10-08" version="1">MQRTARMKKEIQMITVSPPPGISCWQKDESLYHLEAQIIGGEDTPYSGGIFKLEIQIPDRYPFEPPKVKFMTPIYHPNIDTAGRICLDTLKMPPKSNEFKHNKPQFLQTAKLWTEKHAQQDNLNKFKVNVRSCLHRRRFTKVNRDGSDDDIFANIEMTEVIKFLEEHQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2A6</accession>
    <name>A0ABY7E2A6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="99"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="340" mass="37771" checksum="69ABE804EB9E3FEB" modified="2025-10-08" version="1" fragment="single">MKDGPSDKYFRQMFARHPDITEKRAETLDKARKSMSTQQTIDDFFDLYGQLLDDYDLRDKSEQIFNCDEAGWTGRETSRQKVIGPNAAHTYRQQTMVNQHITAHLCMSASGRMLPPFIIFPGSHPHRHYQDGIPDSWLFGVNVSLTQTSSINANCGSVRPVLLIMDNHDAHVNLHTIKAAIENDVVLLGLPAHTTHILQPLDVKVIGPLKARFSKLATNIGHTASTVTLGKAKFSIVLHHAIDQASLASIREAFRLSGLCAINRMGRIYTLHFPTGTSAETCPACGAFRVNPLVAQGLIPESLGHILIPPRMPPMQAKRRKSKAVKSARILTVEEMLNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3K4</accession>
    <name>A0ABY7E3K4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="180" mass="21957" checksum="57CEACE486A524DC" modified="2025-10-08" version="1">MYSGPYSTSSDTYGNYPDYRGDRRDSYQDQYSDRRSVNGGRYSDVVDSWYDRRADMIRRRADHISDARDRRQDFYSNQRGRMFDTLDRRADYSSDPRDHRQDFYSNQRSHMSDTLGRRADYISNARDRHQNVYSDLRDRRSDFYGNQREYYSNPRDMIQDIQKNRRNTASDYYSSFKRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5D3</accession>
    <name>A0ABY7E5D3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36943">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36943:SF1">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045701183" description="Peptidase A2 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26996" checksum="D185D077C845F843" modified="2025-10-08" version="1" fragment="single">MMTDRIIGAMTSLWIGAWTITAGNVAKLCNEADTTVKMNERYGINLKGNPNSCLLKMGKHSVRVLIDSGASTSLISWRFYQSLINKPKLRKISARLEFVSGDSLNVKGKVELTFEMKNLQLTHSFFVVEGINRNIILGDEWLNKNGVRMYFDLGCIRIKDKHVNSICRLTHSITLPPNSSYVTNARVKKRSDLSSEDYYLLEPLNDHYISNQPVVELNNSIVRLTSSRRIPVGIANFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5Y8</accession>
    <name>A0ABY7E5Y8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">INVO-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_019577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052949">
        <property type="entry name" value="PA_immunity-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42999:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42999">
        <property type="entry name" value="ANTIBIOTIC RESISTANCE PROTEIN MCBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1608"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1439"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1331"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1439"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1457"/>
            <end position="1542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR04208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1669" mass="182176" checksum="6BB88CEF0D78419A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6S1</accession>
    <name>A0ABY7E6S1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NR1H3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_019498</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF283">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="10">
        <location>
            <begin position="48"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="229"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR04129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="390" mass="42821" checksum="8409628B6ECE08FD" modified="2025-10-08" version="1">MEVPIGDMDEADRIVLADMNKAHESSAFLSSTQTRLKSLPTNPTEVFNIADGFVRRIIKVAKQVNHFRNIDKDDQIALLKGSVVEIMMLRSAVNFDPKTETWNLSTVNCITKPNPASGSPAGSPSTSNICDLPLPTSGLDLKSLREAAKNGADLSKLRQMARQTSSVGSHDMAAARERYLSGNSSPGSSQSTDSAGLEGLRNAAAAAGFNIEVLRKAAMNGASFEQLSQMAHSGSAATGSPGNGDPPQENSQVKDENDSKPSSISSEILKFGNSETKSMFLTYSKFIKSLMGTIYGDLIVLKFMIMLSLFSPDRQGLKNREKVDNYQQIYAESLRKYIDIRFNNEKNMFARCIMKLTDLRNVNEVHTKMLLKMHVDDIEPLLVEIFDLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E735</accession>
    <name>A0ABY7E735_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ETV1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_021237</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF282">
        <property type="entry name" value="ETV5-RELATED PROTEIN ETS96B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR05868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="201" mass="23244" checksum="B5B38CF7EE0CB860" modified="2025-10-08" version="1" fragment="single">MDVKAEFYRDLYFERYRDLPHPSYQRRGSLQLWQFLVTLLDDPTNAAFIAWTGRGLEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNHRPVLKTDHSSTHSLAEGLYRETSQSPEVQPAFSLPPLTSSFAASSQIPPLPPINVSPTGGTNIFTAPDPHRYPYMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E750</accession>
    <name>A0ABY7E750_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TRA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_020130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR04761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="95" mass="10780" checksum="BD09DFE1AEC32EFF" modified="2025-10-08" version="1">MALAAPSYTVPTRPTVRARVEKRYADERSNLISRLEQATSVSLTTDTWTSNSTESFITVTAHYLDAEWILHSDILMTRAMPERHTAENIASRLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7Z0</accession>
    <name>A0ABY7E7Z0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="108" mass="11919" checksum="98DFE51166175432" modified="2025-10-08" version="1" fragment="single">MFSTINIIVAAVKAVVLQDKLTVYLQNGNEAPEYVYVLEGTAVNLSCHSPLDQIQYSWAKFVDHSVTVDGAFLVLTSIQRHFNNRYTCTARKIGTAETATISVVLIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E895</accession>
    <name>A0ABY7E895_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="81" mass="8779" checksum="BECAA19D9E64DE3C" modified="2025-10-08" version="1">MGTAGLCGARCGGTRRGTAGLGGYGHGRAGRGLHDVQGMTGQSRSTLEIVEKSLTYMRELKEARTKFINRISSYKWCKLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8R1</accession>
    <name>A0ABY7E8R1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="139" mass="15296" checksum="FAB0910C7FBD64CA" modified="2025-10-08" version="1">MELKWFLGIVGVGEACINVLFCYLALILDDWIDHSPFPRVGLWTGWVKPTRAMMFLGLFATIGTTVTASIFMLAGYLIFSEATSHLGLRGGNGSSFCIRACILAWGIAITYAFVFILSKRELPPANLVHASLNPLETHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E999</accession>
    <name>A0ABY7E999_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="81" mass="8624" checksum="990D75EC9CB05988" modified="2025-10-08" version="1">MAVFCNARNEDGMGVFCNARNEDGMGVFCNARNGDGMGVSCNARNDDQLGVFCNARNDDGMAVSCNARNDDGMGVFCNARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9N7</accession>
    <name>A0ABY7E9N7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="379" mass="43871" checksum="15B14B828EF52592" modified="2025-10-08" version="1" fragment="single">MRICDTLIKGANSSFPKRRFKRFLKPYWSESLTKEHMSMWDACELWRRAGRPRVPTDVMFVAYKSAKRKFRLAQRWCIEEYLATIDNTLEHIAKTDPVWKTVNSRRKLSISNSGAGINFNGAMYRDRERSNLYFPSQSQDFDDDWKEHVSRTVQNAFDNIKPEPDAFVSEKMRFKRYLKCKACGSDGILYEHLIYGRAVIAPVLADMFTCMLRLSHIPVSMKIGTITTMHKGGNKRKDDPNNYRAITLVVVFEILILQRCKDQLLTNIDNQQGGFQEQLGCLMSSFALRERLLFAREHSSTVYLCFLDGRILGPYTYKVLSVNGMVPIPACCFRSAWIWSLLYLQVVVGRLGYGPYTYQLLSVFKELVLISERGCRSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9U9</accession>
    <name>A0ABY7E9U9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TUTL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_020897</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF56">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="6">
        <location>
            <begin position="47"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin subtype 2" evidence="5">
        <location>
            <begin position="53"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="6">
        <location>
            <begin position="142"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin subtype 2" evidence="5">
        <location>
            <begin position="148"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="226"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="345"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="797"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="862"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="708"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="871"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="923"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="940"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="955"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1121"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR05528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1161" mass="128913" checksum="AF1175963298623B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAA1</accession>
    <name>A0ABY7EAA1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_016921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16787" checksum="32B0B3A8B5262DD2" modified="2025-10-08" version="1">MVELRWNYKEEFIETSEKTNVVIAAYTTAQSRLKLYSYLEKLGPRALYADTDSVVFSTQPGESVPTLGDYLGYLTDETPGNTIKVFVTGGPKTMLININFDTLKRMVTENKNDVVTVADRFKIVRDRDSARLLTTSQNKDYRLGSINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBH1</accession>
    <name>A0ABY7EBH1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TT21B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_021133</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056832">
        <property type="entry name" value="ARM_TT21_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056836">
        <property type="entry name" value="ARM_TT21_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056835">
        <property type="entry name" value="ARM_TT21_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056834">
        <property type="entry name" value="ARM_TT21_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056833">
        <property type="entry name" value="ARM_TT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040364">
        <property type="entry name" value="TTC21A/TTC21B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699">
        <property type="entry name" value="STI2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 21 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25058">
        <property type="entry name" value="ARM_TT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25060">
        <property type="entry name" value="ARM_TT21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25068">
        <property type="entry name" value="ARM_TT21_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25064">
        <property type="entry name" value="ARM_TT21_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25063">
        <property type="entry name" value="ARM_TT21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25062">
        <property type="entry name" value="ARM_TT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B N-terminal ARM repeat" evidence="6">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B second ARM" evidence="5">
        <location>
            <begin position="215"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="658"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B fourth ARM" evidence="9">
        <location>
            <begin position="694"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="854"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B fifth ARM repeats" evidence="8">
        <location>
            <begin position="855"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B C-terminal ARM" evidence="7">
        <location>
            <begin position="1007"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="1100"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR05764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1180" mass="132829" checksum="7F38781BCCA710F7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBW4</accession>
    <name>A0ABY7EBW4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23163" checksum="5D3AF2F72C7EF2EC" modified="2025-10-08" version="1" fragment="single">QTFKLERTHSRDRRSVHSQKGFIYEDEHISHNAERRDLPLTDTIYIVGSVEIVSTNFVLDTGAMKTVIPIANRPVITKKGTLVHAGGEQLNVLGKCHLSKKLGFVNISSEVAIPDISDDVLLGMDILNGKMGKSADIILSQNKIILDGIEIPCHTNKTNQIRSVIAADHYVIQGESEQIIDVYIKRFESDYNVANPTVLIEPSNNFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBW5</accession>
    <name>A0ABY7EBW5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_021874</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173:SF52">
        <property type="entry name" value="METHIONINE-R-SULFOXIDE REDUCTASE B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="5">
        <location>
            <begin position="56"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR06505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="166" mass="18973" checksum="02649C68FA65DA6A" modified="2025-10-08" version="1" fragment="single">MAMFTIVRRFSPRNICLTRAFLSLKPRENYAASIFAAKSRCYSHPVSHDELRTMTKSEWEERLTPEQFSVCREQCTEPPFSGEFNSHYEKGMYTCVCCGTDLFSSKSKYDSGTGWPSFSDAYKSDKGLSNIIERPENSLDQSTFRTEGFTMSILVLKVGSVFPYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EC00</accession>
    <name>A0ABY7EC00_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ACHA6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_021602</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="15"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="187"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR06233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="334" mass="37193" checksum="61DC15D7062DD2CF" modified="2025-10-08" version="1" fragment="single">NQYYSGSKQSLLKLEINELTGKVSVTGTLELIWKDEELVWKPDDYNYIYSIMVPISEVWYPPLFIGNPDTTATAFKVEDRSYVRLSSDGTISFYPSGVYSVNSPLDSKYYPYDKQTFGIQFLVPGFINTEVNLIEGTVTYIASSFEGDGGWSLLNLTRAVTLVSQYTSAATFTVSLERKSTFMVVNIILPILFLAVINLLVFVLPPDAGERVSYSVTLLLSLAVFVTLLGDNLPKTSDPLPVLSFYLLATLTLSTLMCVMAILNLSIYHKNEQSRPPKCISVVAGAVLCRNTFLKSQKVEDIAETDIKPTMEKQGAEMKVAIEDNKEVTLSWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECE2</accession>
    <name>A0ABY7ECE2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Immunoglobulin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_021986</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045818944" description="Immunoglobulin domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="7">
        <location>
            <begin position="137"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR06617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="282" mass="31549" checksum="03C4BC56B5CEC950" modified="2025-10-08" version="1">MTLPQVFQWNVLHLLLTIAGTQGVFLLTSDKQYAQLQVNITSVTLTPRTDPISVIENVTQRFRCETSRCRPDALITWFLGSTQLTAAIESSTSQEVTTSTIDHTPQKNQHDMNIFCRGDNGDGPNEPVCKLGGLPLSSAVTVKEGWEFRLDCSSDGNPSPSFSWTHPGDGPSYPLFIRSINRTHAGIFRIIARSNLIPSEQKAVNLTKDIYVKVEIHQIYRAAASDRLPYHQTSYLQYAEILSQSPAHVIATRHPHTRGLLPEFPPQLLAKVLTSSFRKRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDN7</accession>
    <name>A0ABY7EDN7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_017232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR07274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="631" mass="70606" checksum="7DCA5C32E0C80B77" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHE1</accession>
    <name>A0ABY7EHE1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RRAS2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_019361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR09403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="107" mass="12563" checksum="690E1A16A16427F3" modified="2025-10-08" version="1">MIPGNMVKSYFVTDYDPTIEDSYAKQCVIDGDVARLDILDTAGQEEFSAMREQYMRSGMGFLLVYSVTDRSSFDEIYKFHKQILRVKDREEFPMILHYQLKIDSSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKT0</accession>
    <name>A0ABY7EKT0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="143" mass="15991" checksum="0AE45FE767E2972D" modified="2025-10-08" version="1" fragment="single">NKRNVCSFRDLKVVDSKSRLSNYCFCKPLYTDPVFDVFYCIRYTNGIEMLSYLGWSLCLKAKHSQQNIIIITLLVRLISANNSSHGTFEYASNSCSQQGGLAYTNIVTTSLLTDYKVNNCSLANGLGLNDGEAMWLHLQADLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKW1</accession>
    <name>A0ABY7EKW1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="198" mass="22897" checksum="84FA8495B7337E2A" modified="2025-10-08" version="1">MRPYFKDAKDTKHNSNGFQRNQMSYRANPVMFKNTISNPMTEPFSWVRYHNNNPKIPLNIASMIIQSHNGREDQNRQSYAIETHHRVKRGFRSAVADRIAHGFGKRGSILDVGVNRLPQVQRLLNLKSLDAEDDEDDIGLLFHLYRMYKRNIHPALNAESTFNSAHGLENDSFRRLIQRLLSAAKDEQFSELRGGPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EP99</accession>
    <name>A0ABY7EP99_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CATL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_018984</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="80"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR09026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="311" mass="34550" checksum="63ADEA350480CDFB" modified="2025-10-08" version="1" fragment="single">KQYANSPEEAQRRAIFADNVEYVNAHNLQYALGKMSYYMGVNQYSDMTFKEWASLYTSQIVDDVSNGNASTFLTPETFKAPGYVDWRRKGYVTSVKNQVLAFCILYSFCIKQLGACGSCWAFSATGAIEGQHFRKTGKLISLSEQQLVDCSRSYGNKGCGGGFKDRAMLYVRDAGGIESEKAYPYYASRSRVFPCRFTKYMAAAKINGVKRVHSSESSLMHAVASQGPIAVSIRVNRNFKSYAGGIFDDSSCINARAGHAVLAVGYGSYPGEYWLVKNSWGPRWGEQGYIRMARNKGNVCRIARSPVFPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQ95</accession>
    <name>A0ABY7EQ95_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="68" mass="7795" checksum="EF7C70718D70D500" modified="2025-10-08" version="1" fragment="single">MRCFVVKAAKTQGTTQNANGFVAPKDDISRPMRIHTYEKPLMHMVLLFPKPDKLRISPRHVMDENLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQY0</accession>
    <name>A0ABY7EQY0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="3">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_026435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF88">
        <property type="entry name" value="BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045976054" description="endo-1,4-beta-xylanase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="CBM-cenC" evidence="8">
        <location>
            <begin position="25"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR12255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="212" mass="23711" checksum="F6A490AE4142DAAD" modified="2025-10-08" version="1">MAGCNVVVFILCVYGYVSRIDAQTNLLQNGDFENTNYAGNWYCQSCTMAPSNDAYHGSHSVKISNRHQNWNGLAQNLNLHATSIYTITAYIKLLTSTNNAQYQEMIMMLNCIDSSGAQKYMKFGEIHYMEKGKWYQVGGADKIPSGYHGCHMYVQTAAPADYLVDEAEVHLNPVLSNWRSDANARIDTYRKADLTVRLTGNNVNAASVQIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERC8</accession>
    <name>A0ABY7ERC8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MPH6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025867</name>
        <name evidence="3" type="ORF">MAR_025886</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019324">
        <property type="entry name" value="MPP6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13582">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13582:SF0">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10175">
        <property type="entry name" value="MPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR11706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="146" mass="16889" checksum="E7AC44BF5F0CEF4A" modified="2025-10-08" version="1">MARDESKTSLSGNFMKRSALRIEKEKSEEERKLIIDDEHWVLDLPKIEGKESKYVIESSIARCENLLFGRMSFQGCNPEVEKLMKLHNNQLALDEAERKENENSVNDQEMAERYSTLVGTMAKKFSKKRDRTSVEMSQQEAPTSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETM5</accession>
    <name>A0ABY7ETM5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CEP72-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_027505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055320">
        <property type="entry name" value="CEP72-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23311:SF5">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 72 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23311">
        <property type="entry name" value="HEAT SHOCK REGULATED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR13325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="855" mass="96770" checksum="07FCB928ACBB246D" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUI2</accession>
    <name>A0ABY7EUI2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="64" mass="7285" checksum="310BD36D868CCA2A" modified="2025-10-08" version="1" fragment="single">MCRRLDGTIQMHCSMCGVEPSPDLPLGRSSPRKVLPDSQLPFRCRPKLPTRLYGGIRNASRRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVA0</accession>
    <name>A0ABY7EVA0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZFP64-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_027059</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF43">
        <property type="entry name" value="ZINC FINGER PROTEIN 64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="544"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="776"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="956"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="787"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="961"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR12879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1016" mass="111398" checksum="089BDC1A9D9AF862" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWX7</accession>
    <name>A0ABY7EWX7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="483" mass="53754" checksum="FBCAA7A229C2770B" modified="2025-10-08" version="1">MEYKTVTKALLRLGIVTCIFSLLSLAIGISSVATGAAFPYDAGGGIIAGVFVACNGTLLTISVLTLIVTVVLAVLSLAILFTCCCNASKFGVPEHERQREIFERERLEDTRNGFNTGTNIETGARLVNGSDAQPRVAIGEQTVSGPVPVSGPDPVYERTLRQREQTLLEERRRERLERERQEDNQNGFSTLDETGTNTESGAVSIVNNSGADPRASTEEPNLFESDSDDRTVSQTEQELLEERRRESIERETQEDNRHRFSTLDETGTNTESGSLSFDNSLGGQPNAPTVEPIISSPDPVHDRTVRQIEHELLEDRRRTRLERERWEENRNRLSTLDEMGTITESGVPSFFNSSVAQPSAPPLVPNFSGPDSAYDRTVRQIERELLDNLRRNRLQRERREENRNLFSTLDETGTNTDLDAPNYVYNSGAQPSAPPVEPSPHADLPPSYEEALPSYEEALPSYAEVMEDEDKYIKTKTSISSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWY3</accession>
    <name>A0ABY7EWY3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF25">
        <property type="entry name" value="CNMAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="46163" checksum="C7D477527A368628" modified="2025-10-08" version="1">MDSVYAGNGTGYSDDELYDGYQDYYIIVPTPAETFVHYFYLIVFPYFLFFGTFGNIISTALLSRYSHNVWSTCVYMTLIFPLDLIKLYVECGNDWIGELSNKELNLSAKILLMSNAVCKVYTFVYSLLLQEVRWILVAIAIETMIVLKTPTRIYNMCTRERANAIMLFISVMLITLDLHFFWTHGLVRPGDDPSISFFMCTYVNELSDDFRDYIWPNINFFIKDILPCCIILGCIVVSITGLVRKSSRVYDNYLEKYFLDTKALRELSKAMFVVCIVSFLSTMCDIIEYSLLFMINSGILEIEYDKNILIMSSLSVSKNIFVSHKFWIFYVFCERFRSDVKNLFRALCRPFKWRAGRKFNRRYVEESQEREITLPESEACLNEHFVATYSENNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXE9</accession>
    <name>A0ABY7EXE9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SF3B3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_027809</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="5">
        <location>
            <begin position="14"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="6">
        <location>
            <begin position="438"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="4">
        <location>
            <begin position="850"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="799"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR13629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1200" mass="132669" checksum="C922ECE35D5254D9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXJ4</accession>
    <name>A0ABY7EXJ4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GEM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_026086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF6">
        <property type="entry name" value="RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR11906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="410" mass="45870" checksum="AEBA36B06C53A4D3" modified="2025-10-08" version="1">MTKKAMNADKNERKHSVPKIRHEVSNDVKTDHEERTVADKNQRKIQILASEQGSHSSSILTPTAHHGRSSSFRSRPRPKLLNVDGDRPRRSSLPSPSANLLSVSFGNIPKHKETSDEQPLQRVRSFKTTSKGGIVNRGDSFKRSSNSINSTGSAMHSEHGGARSHNNSRQRINSTQSRDSDTADSTGSSMDTVIHKVAMLGDKGVGITSLTNQFMTSEFVAFETENDDDETDRHVTVLLNSEETTLKIVDRPINLKEMSSQSFDAFAVVYSITDRASYQAAVDILYLIRHQLAIQDKPTVLIANKIDLVRKRKVTREEGRSVAKQYTCKYCETSAALNHHVDELLVGILSQIRLHKTPGLQKDPPNFDVRPSQNKVAKCSMPGPKRLLNFIFRKKTMQPSCHECENLFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EY97</accession>
    <name>A0ABY7EY97_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="161" mass="18082" checksum="69BC9B5AC9525FC8" modified="2025-10-08" version="1">MLDHGCDNFGYSMAFGGVASHCFRLFFNRETLANGPPWSQTLYVMLYVLIVGLMFYPMFACLSTNWRFLGATMGLGYSTMCYTNLPGETIATQLPVLICLIGLSLRFLFIMFGIIILLASYQLRQLGKLLIPANQTANGTDEESIYQLKLFFTTTNGSKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F214</accession>
    <name>A0ABY7F214_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NOC2L-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_005835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR15730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="565" mass="64381" checksum="B6B94550043DB7A4" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2F4</accession>
    <name>A0ABY7F2F4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VLPF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="285" mass="32106" checksum="5F76E5DF565F5DFE" modified="2025-10-08" version="1">MKATIFWMGLTDEISEGRWIWRDTGLEPTYTGWSPGEPNSFQGENEDCSIFYVTTNYAWADASCLGKFPPCCEIDDMSTYTTDLGNNSDMSTYTTDLFINSDMSIYTTDLSNNSDISTYTTDLVNNSDMSIYTTDLVNNSDMSTYTTDLFNNSDMSTYTTDLFNHSDMSIYTTDLFNNSDMSTYTTDLGNNSDMSTYTTDLFINSDMSIYTTDLGNNSDISTYTTDLVNNSDMSIYTTDLVNNSDMSTYTTDLFNNSDMSTYTSNLINNSDMSTYTTDLFNNSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F480</accession>
    <name>A0ABY7F480_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZC21A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_031021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR16427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="249" mass="26800" checksum="69522AB5885A63FE" modified="2025-10-08" version="1" fragment="single">ISGRNVKLDLRPCRTCGRTFVPESLKKHEASCKNVQKKRKPFDASKQRATEDLSLKQIKQAQKKNVAPPKSNWRSQHQEFISNIRAAKGAQVAMERGDPLPPPPPPSLNPDYVTCPHCARRFNEKAAERHISFCQEQQKRINVNKKREPSQQEKARAAAAKYQPPKPKLKSQMDSPSGPTSGGYGASRGGYSSGSPAGRAGPGASSRAPPPGASKSDVGRSPAGSTGRGGAAAPRGRAPQQGYAGRYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5A2</accession>
    <name>A0ABY7F5A2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053236">
        <property type="entry name" value="Cornifin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13884:SF16">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13884">
        <property type="entry name" value="DUF853 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="368" mass="41545" checksum="151C9ED569C797BF" modified="2025-10-08" version="1">MQIITAQFSYRPVSGNTDNDRAPLMAAAPGTDCTGDEALCNANETCNNNKCACKPAFKNMSSGCVAKGYNDTCTNSDECTSGPLGAMGICTTGKCGCKTGVNLTTRPGGTMTLTPVLEAPWSRLQENSSAPVQEGPSSRLQEYTLPPLQTAPWSRLQVYTLLPVQEARWSRLQVYTLPPVQEAPRSRIQEYILPPVQEGPWSWLQEYTLLSVQKARWSRLQVYTLPPVQEAPRSRLQEYTLPPVQEALWSRLLEYTLPPVQEALWSRLQEYTLPPVHMAPWFRLQEYALLPVQVARWSRLQEFTLPPVLMAPLSGLQEYAYQQSRRGHDLRFQEYALPTVQEAPWSKLREYTLPPVQEAPLSRLHEYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F747</accession>
    <name>A0ABY7F747_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KLH18-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_031117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="30"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR16523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="496" mass="56068" checksum="4571D0AB5DE24DCA" modified="2025-10-08" version="1">MIESRTCSIPNHGRTALQTMHELRRENVLCDVILCVDGERFPAHKIVLAGSSPYLKAMFTNGMLETEQDVVEIKDFDAPTMQCLLDFMYTSTIEITVNNVQSILQGASLFGLQQLRVLSIQAFADVYMCAELERAARQFIYQNFLPVAHTEEFLQLSEEKIISLLRSDQLHVMSESQVFDAAYSWLTYDKSRTESACNILKHIKLGLLELPMLENVVIKSDFFRTCHKCQSLISSAIRSQYERKNMELLTPRAHPPCIYVPGMNIARTAIGSATLDGLLYTVGGECALIDTQENTLYLRCMECYDPVQRQWLPKPEMKIARSFVALAAVGGYLYAIASMKRRRAGSGITVCEGKIYVAGGYDRTLHMDRASMECYDPVIDDWTFMSEMEKARSGLVMATIDQNVYAFGGRYRHTDQYYDMVERFNVLTRQWTTLAQMNTPRAWPGIAIFDGRIYVLGGFDGGYRLRSAESYDAETDQWTPISNMLVSRAGCGAAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7Q6</accession>
    <name>A0ABY7F7Q6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MEG10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_031646</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046447783" evidence="4">
        <location>
            <begin position="19"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="799"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="1279"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="854"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="961"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="968"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR17052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1553" mass="170093" checksum="17BF5CBB3B497F4B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9N6</accession>
    <name>A0ABY7F9N6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_000155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="622"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR18317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="761" mass="83964" checksum="6103562CF617AC36" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAR3</accession>
    <name>A0ABY7FAR3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_032362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049507">
        <property type="entry name" value="SHLD2_OB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF143">
        <property type="entry name" value="SI:DKEY-56D12.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21669">
        <property type="entry name" value="SHLD2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shieldin complex subunit 2 first OB fold" evidence="4">
        <location>
            <begin position="93"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="200"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR17768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="333" mass="37773" checksum="4F7772F17CBF053C" modified="2025-10-08" version="1" fragment="single">MARHACCAKVFDELKFSKFAFGTSVVLRDVIQKTEDSRHIVVTKNTKVFVTSKVACPDAHITEGQAIVNPPPADVEGAKRTVKVCGEDVDIRVVTLEENQVRAKVTLWRDATELTVKAGDYVSITDVVVNMFKGEASLSSTSRSKVEEEEERTVKTQGQDTQIKALIVEDASGRASVTMWRNQINRDVRPGNYIEMTDLVVSTYKNSTTFSTTAGSTVTNEQQTWMSGKRHYPTTNIMIQQKLMYNLKPGDAVMVYRVFNVAMELKKNRVKLLNPDFKGRDRDRSSQQEDKRSEYISKARIHVERLIQRIKTVHFLERSVCLNMLNNITQVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBA0</accession>
    <name>A0ABY7FBA0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SQOR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="27"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="377" mass="41961" checksum="8097628570CF4BA3" modified="2025-10-08" version="1">MALSTNKVGKVFVHFVRNYSAETTKHYKVVVAGGGSGGLSIGARACRQFGVGNVAIIEPAKVHYYQPMWTLVGAGVKTLSQSGVPTQEALPRGCKHYNQYLQEFDPERNTVTLKNGEKLSYDYLVVALGIQIDLKKVEGLEEALKNDKNVCTNYLREYVEKTFPAIQDFRGGNAIFTFPNTPIKCAGAPQKIMYLAEDYWKKHGVKDKTKILYNTALGVIFGVPRYAESLMKYDFLHVGPPQSGPDVLKNSSVPIVDATGFLDVDKNTCQHVKFPNIFGIGDCTNIPAAKTAAAVAACSGHLWRGIKDMEAGKKPSGTFGFDGQIYETFPLDQSKERRTMYHLKRDVMPQIYWHMFLKGYWNGPGTYRKIMHLGMCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBS8</accession>
    <name>A0ABY7FBS8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">XFIN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_032722</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR18128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2590">
        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF189">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="744"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="772"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR18128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="799" mass="92078" checksum="77487FAA8BD9C24C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBX8</accession>
    <name>A0ABY7FBX8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="62"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="470" mass="53834" checksum="3ED773CE07AA9063" modified="2025-10-08" version="1">MSSLIPAHIPHPLDEEMKKMSLNNETTYSDCVKIMDECSGSINRWYTKAGRGIRLTSFQKMAKKFLNLQCGRDQGTLGNMKIQIQRTNVNGNVKSRYKAHEDFVVTCGLSYFLSYIMHHFNMATITDSRKHNSITEGLSNWTNVNKMKVFNTLMEEILTDLYIPFDVQGMEQDDSHEVEVTIQEHETLQCYQYTANVTDGKNVNIPLNINGCDLVVVTNLESLKKGCSLKVVNTEINVMLKTVKKNDDLLNYVKNFLQWFFIIVQMKDAIREGDVKRISIVLKNMIPFFYSHSRLSKYLTECIDYILKTEHTLSPYMSLKVQAGSVVNPKGRPGKNKAADIQKENEVKLLKTLIRSLGANKTEKSIVAITKAAPEIFRITENFESMIKLKAVKSSHKAKSMADDIQILLGKINPLDIWTRHHDRQLQQKVPRSPFAFDKAGLIYIIEITVKRLLRDLPVNNDEDEENEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCF4</accession>
    <name>A0ABY7FCF4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_000702</name>
        <name evidence="5" type="ORF">MAR_002474</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF281">
        <property type="entry name" value="PAPILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="ADAMTS/ADAMTS-like cysteine-rich" evidence="3">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR18864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR20636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="88" mass="9555" checksum="A5A59BCE0DD497AB" modified="2025-10-08" version="1">MFYHKLADRVVDGTPCHDDPSRRCVHGQCKSIGCDWKVGSYKQTDQCGVCGGDGSSCLGGGEVTGTFHQQRLSPGYLHQIKLITLVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCR6</accession>
    <name>A0ABY7FCR6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="596" mass="69064" checksum="8DE6EE40D9196BE7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FD77</accession>
    <name>A0ABY7FD77_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CAuncharacterized</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_000825</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00214">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033883">
        <property type="entry name" value="C2_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF433">
        <property type="entry name" value="CALPAIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="117"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="922"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="567"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="692"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="716"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="761"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR18987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="982" mass="108988" checksum="DD3F2650C4502CD3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDG6</accession>
    <name>A0ABY7FDG6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZN839-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_000596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031885">
        <property type="entry name" value="DUF4764"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039946">
        <property type="entry name" value="ZN839"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16116">
        <property type="entry name" value="ZINC FINGER PROTEIN 839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16116:SF5">
        <property type="entry name" value="ZINC FINGER PROTEIN 839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15961">
        <property type="entry name" value="DUF4764"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="375"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="958"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="958"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR18758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1313" mass="143661" checksum="4FF873BAB0B0DF8E" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDS0</accession>
    <name>A0ABY7FDS0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MEG10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_032005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046133355" evidence="3">
        <location>
            <begin position="17"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="5">
        <location>
            <begin position="134"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="5">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR17411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="399" mass="44954" checksum="D709F7992CE09369" modified="2025-10-08" version="1" fragment="single">MYACAVLLILVRVVCAQDCSTCKDREDGHDRKCSNTGKCYFGCIDGYYGNNCLHNCTYQSCISCYQNTGHYCLKCKSGYYLYYTHCHPCNSKCKSCDSLQRCLSCYDGHWGSTCQNKCSSECKNGHCDEESSSCRCSPNYKGETCDQCANGWFGQTCQYECSRDCKNGYCDKESAVCRCSPNYKGETCDQCSNGRFGKTCQYWCSRACKNGHCDEESGFCRCSPNFKGETCDQCSNGQFGEKCEHNCSLGCEFGNCTRDTGFCPCKSEWSGQRCKTKTETNVEQHTQSIAALLGGVCGGVVIFVGIVVIGHFLLRRRRANFSEKKSKLTEREPENFFALYATVIESEDRDDISPREITVENEDIYCNNAKEVGKFKLTVADLPEYVQYICLKDLEEEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDS2</accession>
    <name>A0ABY7FDS2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PEG3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_000759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR18921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="107" mass="12925" checksum="4E9C5D612684A030" modified="2025-10-08" version="1">MEPIPNNTSYIWNETSYSMKPNNTSYIWNETSYSMRPNNTSYIWNETSYSMRPNNTSYIWNETSYSMRPNNTSYIWNETSYSMRPNNTSYIWNETSYSMRTNNTSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFG7</accession>
    <name>A0ABY7FFG7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TSN33-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_014912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF431">
        <property type="entry name" value="TETRASPANIN 26A, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR20938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="175" mass="19527" checksum="9F54E4290D1C978D" modified="2025-10-08" version="1">MARLANSSLVSGAVAGLMIWILVEKEKTVSSIYDFFLDGACIFLLVSLIAFVVSFLGWIGAFRENICCLKGYHWTMTILFFVQIVIVILIFVVVFVPEARNQLGIYPEDSLRVAIEKYRDDPDMQNLIDNFQLTDPLTRTAAIHTDGCLKAITDFMNNNVIVVGGVLMGVFIPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGU4</accession>
    <name>A0ABY7FGU4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_002232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR20394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="611" mass="72356" checksum="20FCBA366E614C85" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGU7</accession>
    <name>A0ABY7FGU7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CYGB2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_000299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00188">
        <property type="entry name" value="PLANTGLOBIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="8">
        <location>
            <begin position="48"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR18461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="196" mass="22303" checksum="3AF9AAAAF5BDD769" modified="2025-10-08" version="1">MGCIYSKTRKEALRKNKSVNTQYRKKYLPANTGDGDNNGNSQTPTLPEFTDCQKDLVTKSWTVVKADMDQVGINMLMKLFTSHPDVQDVFAPFRGMSPEDLSQSNQLRSHAMRVMGTVDKCLSCIYESDKVVKILKELGSRHVMYTAKVDYMDLIGPQFILAIQPVLDDEWTPELEQAWSDLFKLIAFIMKASMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FH21</accession>
    <name>A0ABY7FH21_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SMYD3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="228" mass="26150" checksum="D31C2E463C437DC0" modified="2025-10-08" version="1">MYWMFGHILLQQSLPDSEDIKKDAERSEQFAQVAFTLKEYAGSHVSLPDASKLLNLFGKVFISYIDQLAPRKERQTALKKQYYFDCACSRCSDEQFWKGVFETCKESIQKAAGVLHAHNVYLVRILDLAFDAAINLEKWELAAKYGARTLQPYCTFYGEMSPHLAVQLFKVGKLQLYLGDDLKGALQSLERAQNIFKVTQGEGHEILNTLELFVGQCREEMRMKLEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLZ4</accession>
    <name>A0ABY7FLZ4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_036914</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="4">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0041">Annexin</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR23245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="352" mass="39829" checksum="0B83D019ACFACF4B" modified="2025-10-08" version="1">MFGLYFCIFRCHGSQGTVLGQGEKLDLDTTAKKLRKAMKGLGTDEKSIIEVLSSHTNNELQLVKDFYKTCYGRILGEDFQSELSGHFEKLCLYLLLPRPHFQAYCLHQAMEGVGTDETTLVEILCTRNNQEIGEIKKAYKERFKCDLEKDIVGDTSGHLRRVLVSIVQGSRSEEQILDQQLVQKDVKDLLKAGVKIVGTDESAFNRILVSRSVPHLQEVFKGYKEKDQQDIIAAIKSETSGSVRDAYLAIVRYVVDPLEYFAECFYDSLKGAGTKDERLMQLVVNHCEIDLKDIADTYLQRYKVGLPCAIQEDTSGDYRKMLMRLTNVYLVQAPSTLHDYVVQPGTEQQAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMN9</accession>
    <name>A0ABY7FMN9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR23465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="178" mass="20136" checksum="5F91678CFB9C2F52" modified="2025-10-08" version="1">MGLWQGCREANGSWMCTNEIFEDEVFQSGSDWHVGSQVMMTLALILLFLLEFVLLGYVCIHRFQKYKNKLVAFIIGLSVSAGALTLTTIILVAIEASRAPRGHLEWSYGMLLLALSFEILCFGIVLFNAYQNRLLGKSMTRASERRDMVETASMDDNPFSYVNQTFTIVDLHLDETAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPA7</accession>
    <name>A0ABY7FPA7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YTDC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_036368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="270"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR22699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="592" mass="67997" checksum="9C9F99E9F71755AD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPT7</accession>
    <name>A0ABY7FPT7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear transcription factor Y subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CAAT box DNA-binding protein subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Nuclear transcription factor Y subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_036838</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR23169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="245" mass="27277" checksum="5F065BAF78300F95" modified="2025-10-08" version="1" fragment="single">MKLDEDVKMISAEAPVLFAKACEIFISELSLRAWLHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPREDIKPAKRQDEARTSVLPEQIQYYLQLAQQQAQQNQQGATSQASAQPVTQALAQSAAGTTPQLQLAGGQILQQPFQSQSQVITIQPPQVQQQQVQQPQQVQQVQVQQPQVFQQVINPSGQIENVPIQLTPQQLQVIQMQLQGKTSNQPIIIQTSASQPTTSQSIVTQGDATQLFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQT4</accession>
    <name>A0ABY7FQT4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPSD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_037626</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="42"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR23957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="349" mass="39163" checksum="5919445D458BB6DD" modified="2025-10-08" version="1">MRENSNITYILPRWEHYPPLATETYIVIVVVIVLTLIVGTLGNCTVIFLFAKYKSLRTTPNILLLNLTVASLLMCVFSMPIIIVHCIVDQPNYQDQVQAFVCNGDAFTGAFVGFSGILSVTALAIDRCNVISRQNGGHRSGSKKFSYCSTVLIFIISFTSALAPLLGFGKFVQDGSEIFCTFDFFTRSVNNVMYNVFIQLTFFVVPLIAIVTSYTCIYLTVRKHERTFFKGNKGIENQECSLRRICKERKQVKTEVKIAKVTVICVSVFCISWFPYAMVALIGLFGDCEGIDRMVTALPAIFAKVSTVLNPLIYVILQGQFKKKIVLMLYRRPDGVRLLSTTEQTSTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXH3</accession>
    <name>A0ABY7FXH3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_012404</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="5">
        <location>
            <begin position="31"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR26700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="142" mass="16555" checksum="A98E68A046C1D423" modified="2025-10-08" version="1">MAPAMIEDFKNDPDFPPLYPVKFERNKYWNAKDLLQDASAHARVFLMCVNADEMRTILYQAGMMGFGGEYVYIAIQLATISWWGTYRKFLNDMMDQTLKKVYENVLILELINPVEDNGPFQDEIRDLALNEFDYTFAENETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXI4</accession>
    <name>A0ABY7FXI4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_012632</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034720">
        <property type="entry name" value="Viral_alk_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01771">
        <property type="entry name" value="Viral_alk_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR26928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="146" mass="16238" checksum="B34546DC53C465A0" modified="2025-10-08" version="1">MEVETTPVPPSVIDDSLVVTIEAMTRGQMTNKLWCLLHRGRITSSNFGRVMAAGKSPNHLIADIINVSSLNKYSNLLVQVKWGQDHEDTARADYIKFKEATGTPMEVLETGLHLKPYATYLGASCDGIVIDKSMPCHCQKGKWKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FY24</accession>
    <name>A0ABY7FY24_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF3">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="363" mass="41260" checksum="2A5BB8FF880A325B" modified="2025-10-08" version="1">MTSEKQLRLPSDDVKWEKNKSNAWPKLMYEDLVDYLIHAKAYDGKAMKSFRSLYGYNCTKCGPLIVRAKISPSQPGVGRKDYNSWIAVSSENTVETGHCTCPAGNARSCSHISAFIYAITLAWANGVGKHVQTNSGLGVKEQRKYGHMTPFQIWCLTKTTENQNSCVWTDSRKLRLTSSKVNDLPKTKRANPNKFVTNQIYPRDDLLHVMDRNTNQLHEPGMKVFLVTSLTEPYIAASPDGIIDKRTIVEIKCPTRPLEDLISSGKYDVLLEDGQPKLSPKGKNGYYCQVQVAMFCTESTLCKFVVWTAEKQCVVDVPYCKDFIKGILPRIRDFYFKHLLVRLTDEFQASRLKISPEYKSLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYW1</accession>
    <name>A0ABY7FYW1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="166" mass="18294" checksum="5EEF7A435DC1A6A1" modified="2025-10-08" version="1">MKISCGKLGLQTRTWSYLMTLSTEGTCADQTFCRRMAKRLKTNEEKNEQEPGGERNVPGNSATTAATVSELTKSHTGAFGDSSVIPPSDMVKALIMAADNDMPELNRVEFARTLSDDDDAEAYDPIFEESELPPRPVKHKKKKSKDGKSLKHSSSDNEKAKPQTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZ04</accession>
    <name>A0ABY7FZ04_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ZIC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_013099</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041643">
        <property type="entry name" value="Znf_ZIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18366">
        <property type="entry name" value="zf_ZIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR27395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="292" mass="32942" checksum="064F5BF0D8361704" modified="2025-10-08" version="1">MINPFMDTPHTPHLPPGAMKLSPPHMSDGSSIHNQLNQYVPQTNGYSVGMPTSHLSSYASRDYLLRRDMGLQSHESNSMFIPSSGSYHSTHHDTGSSHVLFPGIHDATTHPGSQFNSQMRLGLAGADMYSRDHFNQMSAPRADHFSHQPHFNTMNPMNAMNHMSMGPHGPGAFFRYMRPPIKQEHTCLWSDKDQPEPKKPCNKTFTTMHEIVTHITVEHVGGPEQTDHACYWQNCPRDGRPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGFDLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZP2</accession>
    <name>A0ABY7FZP2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">lysozyme</fullName>
            <ecNumber evidence="1">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_012123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 22 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="1"/>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd16899">
        <property type="entry name" value="LYZ_C_invert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001916">
        <property type="entry name" value="Glyco_hydro_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407">
        <property type="entry name" value="LYSOZYME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407:SF63">
        <property type="entry name" value="LYSOZYME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00062">
        <property type="entry name" value="Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00135">
        <property type="entry name" value="LYZLACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00263">
        <property type="entry name" value="LYZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51348">
        <property type="entry name" value="GLYCOSYL_HYDROL_F22_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="2" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045268584" description="lysozyme" evidence="5">
        <location>
            <begin position="19"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR26419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="147" mass="16410" checksum="1A7B82F9505593B8" modified="2025-10-08" version="1">MMHSLALLLLCLPYLAQGYIYTKCELARDLLAENVAKSELHKWVCMAWYESSFNTAAVNQNSPNSVDHGLFQINSYWNCDPQNGKPAKNGCGHPCSDYKNTDLTDDVACIKKLKREHKGWGFSMSYTNNCQSKTSSYISECGIPGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZY2</accession>
    <name>A0ABY7FZY2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="37"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="128" mass="13439" checksum="ABE8D62FB4E33057" modified="2025-10-08" version="1">MSTQPHDSTACPKVGRLICEVTNEGKTTASSSCRANCTDKPTGPSIKDQYFKLVGTGVSPPPNVTTISHVTTGSPRLCGVECLKVSVCGSFLLNPGSSQCLLYAGNHSSTVVQGPIGVKYFVKYKNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G117</accession>
    <name>A0ABY7G117_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_012465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="437"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="508"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR26761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="72301" checksum="6C8D23EEAC0618E5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G172</accession>
    <name>A0ABY7G172_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRI33-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_012525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="77"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR26821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="292" mass="33257" checksum="FE3BC974303E1D94" modified="2025-10-08" version="1" fragment="single">MAANYSSSVYQTFDLIHDFACSTCKDDGLNNEAQFFCGDCKKYYCNNCVQLHNKLFRAHSVLGKQDVSKWVGYAGLSPLEICDKHSDKKLELVCEDHDELCCPICFSLTHRMCQGIKRIPDLVDGLKKQTDFIKMPADVQKIIYMLQEITQKRTNNKQSLKGSGKKLLVEIKSLRQRINAKLDILEEKTNAILKVQLNKADDILQDDIDKCTDLTYKLKTYLQTIQSQQDDSNSYIAYKKCTDKMREAESLLKQLSVNPNKSPAFCGDPRIEKFLSGLNSLGKILCIHGVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1R6</accession>
    <name>A0ABY7G1R6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_014074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR28370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="208" mass="22881" checksum="0AA4381B9779B8A5" modified="2025-10-08" version="1">MDELGVHETDRIVKINMEIEGYTLATVDSSRQTVAGSREEWTCRRACLVIAVSAVIGCLLSWTVLIPVFYTSRSSSSDPILNSSGSEQTVGSRVLPSPNESCVVAPEAGLYRVYSQITFAFDGRTHRSEVAHSVLVRTGDDEYMVQKKLISVPFRDPKLSKRHQTMDPSNLITSAKVATDDRICILVSPVGLVYKSQVDNVLMVVKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G305</accession>
    <name>A0ABY7G305_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LHPL6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_013996</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489:SF16">
        <property type="entry name" value="LHFPL TETRASPAN SUBFAMILY MEMBER 6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489">
        <property type="entry name" value="LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR28292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="188" mass="20103" checksum="4256DF68CDAAC095" modified="2025-10-08" version="1">MSGLSGVGVFWAFTSILSAIISCVGYFMPHWITGRITLQHPGKSPQITPVHFGIFRRCNYPYIGDDGTLTISHECGRYTAFSDIPSVSWQIATLTVGVGCCLCLLVSLTAMFGVCVKGVVIPTVARTAGIIQMCSGFLMGAGVGIYPNGWDSPEVKQACGHISKSYNLGDCSLSWCFYVTSAEATLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3A5</accession>
    <name>A0ABY7G3A5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RSF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_013496</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd15543">
        <property type="entry name" value="PHD_RSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028938">
        <property type="entry name" value="Rsf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296:SF16">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="1089"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="654"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="921"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1063"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1163"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="925"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="945"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="972"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="999"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1019"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1036"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1163"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1212"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1224"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1252"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1291"/>
            <end position="1304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR27792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1304" mass="145910" checksum="18A9D8DA620B6E6C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3F5</accession>
    <name>A0ABY7G3F5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_013628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tumor necrosis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471:SF13">
        <property type="entry name" value="TNF FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471">
        <property type="entry name" value="TUMOR NECROSIS FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50049">
        <property type="entry name" value="THD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="THD" evidence="6">
        <location>
            <begin position="126"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR27924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="275" mass="31349" checksum="166D4732A8F0A428" modified="2025-10-08" version="1">MALSITLKVFAFSNIVFTCILCISFVSIISLFPIKISQKSIKYATNMCVSCDELQSFPGFPAVASEDIDRLRSAKNKSSCCSSTDEILRMRIRKVYEYNSGLAAETITNILGKDNCDIFHPDENVPLAKVVGVVDHVRSSFQTDLRKIRWKKNGASATNGDITHLEEEGEIFIKQEGTYVVLSKLRVHRDPSTPFAANLSHVLFRLTHKYESETVLMQRSRTLCHASDDQYDSFISAVFRFHKYDRISIHTTHAQHLQINDTENFFGVFFTYDMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6E6</accession>
    <name>A0ABY7G6E6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MEST-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="195" mass="22037" checksum="2DE34B65152541D1" modified="2025-10-08" version="1">MGYQNIAWIVVVTAATVYFLNIPPPPLSSTLLNWQKKGDIFKYKGFDIFYIVEEGVPSDGSTLLEHDYLITEQADIHEALLTSLSIPRAHVMSHDYGDTVALELLHRLIKYITQRAENKDRWVGALVKTKLPVHMIYGPSDPVNSGYAFVDHYKKVVPSPSITVLDAAIGHYPQWEDPNAVFESYKSFLQSIKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6Z0</accession>
    <name>A0ABY7G6Z0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046369095" evidence="1">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="173" mass="19206" checksum="3A752A35B650EEB6" modified="2025-10-08" version="1">MGSFKSLVLLAMVCVQLQMIASMTNYEFYQAVKPYIDDENVEYRGRAVADDDDVIYLPGGPNDEFDHMPALCYGVPGLSIAKVCLDLYGLDMAQRKICAKVVGKLDIKVHEFKVNLDLGCVKIPILKDADSLYLGQAGADDVDMPYADVTKPADRLMSLFVTELWKSLNNLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7S1</accession>
    <name>A0ABY7G7S1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_033010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRCR" evidence="3">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR30468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="108" mass="11716" checksum="FB4A1D1BCDA70D42" modified="2025-10-08" version="1" fragment="single">FLDYTLENISLSASGVIQVGVNGQLWAVCDAFFTLETANSVCTVLGFHGTGSFAVKTNGDDLDTEILGSIICNPNTKSIIDCHIKHQFSYLSYHPSTECKGYVMLTCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9J0</accession>
    <name>A0ABY7G9J0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HLX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_033337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052497">
        <property type="entry name" value="H2.0_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46808">
        <property type="entry name" value="H2.0-LIKE HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46808:SF1">
        <property type="entry name" value="H2.0-LIKE HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="253"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="255"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR30795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="315" mass="34646" checksum="44E9E7E7E8A1606D" modified="2025-10-08" version="1">MFLNTCSGCVQIPTPMYYWNPYVLSSYGKKPEVNIADVLQLHAAKYANVKAAAESKRSSDNLRELALGRYTIDDRRIENNSSVTDSAKTALECDGALNYSRKDGTACGTCTLPSALEPLRALCSAGPRGYTPSSPGTTPGEHQKWRPDTQEATGNKELKFGINKILSDEFGKENSDSRTTKLVSTPRAHGKCECTYDRCRGYSTHLQYPGHVLSAVNALQPPNYPTSPNGSDILPGPYSVLSTDVSLGAQSKRKRSWSRAVFSNLQRKGLERRFEVQKYVTKPDRRQLAAMLGLTDAQVGHVTAAKKIKEITYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GA90</accession>
    <name>A0ABY7GA90_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SPNS1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_033884</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd17328">
        <property type="entry name" value="MFS_spinster_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF79">
        <property type="entry name" value="PROTEIN SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="31"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR31342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="509" mass="56225" checksum="CDCF38009A13F5C7" modified="2025-10-08" version="1">MASTEEQSNVNDVMVAPEMFWQKISIYQVYTLIIFLITYLLNQLDRYMLAITIKPMSQELKFGDMDCMLLSNYSSNDAISNGAKCEDAKDTKSCFAKTYGNGSEAINPCKWDYNGQGFEYQIVAGPVFIVIYTFAGIFISFAADKYNRKVMLGACLILWSVMTLLTGFIKEYWQLVLLRFGLGFGEAGCTPFVASMLTDIYPTELRGTALGIYNWGIYMGYSLSYALGIPGILMGLLIFVTVKEPERKNASMQSEQKDTQSEQPKASICQRLGTILKPFLAPSLMLAILAGSVRNAAGYVFAYNTQPYFTGIGQTKEDIAKYMGWIPIVGGSLGVAVGGFISDRVVKGRGIYARVVVVIFSLLVAAPFAAGTLFLSPPWAYICQIPTYLFGEMWIGITLAIVVEMIPSNIRTSAVAVYLFIISNIGGNMPLLVPPIQQAFENGALYILYPGLYVAGAVLFIPAMFLLKRDQKRMQFMEYVNMQDSSKALGKMPGEANPAYQDSEKPPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAA8</accession>
    <name>A0ABY7GAA8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Guanylate-binding protein/Atlastin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1000.10">
        <property type="entry name" value="Guanylate-binding protein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003191">
        <property type="entry name" value="Guanylate-bd/ATL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02841">
        <property type="entry name" value="GBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate-binding protein/Atlastin C-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR30252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="435" mass="51912" checksum="E06DD2D522974104" modified="2025-10-08" version="1">MSVTYFKHSSMEYLCVKSKSENEEHITEYCENSLEALQSQSLLIDGIHNKSYAVVGGHMKFKCDLERVRQEYHLELKDKGYENRETATTWSTFMQTLAKPELEIIQLDNSLSEEEKKREREENKQEMQRMVHQIEEQNKQLLEEQSASYKDQQQETDKNERELLQQRILLLKEEDKERRKEERQWREDEQQRRDESENKRDEKLRQWREDEKERYKRAEEDLRTRMQNLQQKSDHKDEEANLMESLYGPRKEVGCGDTAMPVDFQLSVESSKKLAENCNHWQDLSIQIDKSREIEQRTRSQAGSSEWFDERRPRLTASKFGPIMTRKKSVNESFLRNTFFQEQFVSKPTTYELLNEKTAKVIARIRSFQTDNCYHRVHSGCQTENGSRRLRGEGQCACKRNKTDNVSHREHWGCQCASNGNYIEKDSQLNMRDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GC24</accession>
    <name>A0ABY7GC24_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_034517</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="10">
        <location>
            <begin position="162"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR31975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="314" mass="36136" checksum="C579A22552189E7B" modified="2025-10-08" version="1" fragment="single">APLSSTFLSFPCKIAEIRLDRALACGQNFRWKQTTQGEWTGVIGNAVWRLKQSETEIFYQTFRNVHSTLPMIHPMHKFSSEDSLESCCKCVSNGKKSEDIMCNCQKTDLNILRDYLQLNVSLENMYELWSESDENFRNVARTFTGIRMLRQDPIECLFSFICSSNNNISRITSMVEKLASNYGEKIMELDGQEYFSFPQVSSLAKDGVEERLRTLGFGYRAKYIQVADCVLLMCLDKPGAIPVDTHVWQIAARDYMPKLKQAKSLTDTLRSLQKFMGALCWMGSQYSLLLTSASSKNLDQRSQWYHHLVKEDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D713</accession>
    <name>A0ABY7D713_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KY-like immunoglobulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056564">
        <property type="entry name" value="Ig-like_KY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053041">
        <property type="entry name" value="Transglut-like_Superfamily_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020:SF1">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23265">
        <property type="entry name" value="Ig-like_KY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KY-like immunoglobulin-like" evidence="1">
        <location>
            <begin position="198"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ93464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="749" mass="86074" checksum="D4C518935646592C" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DB30</accession>
    <name>A0ABY7DB30_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ93589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="136" mass="15241" checksum="0A32B19409514215" modified="2025-10-08" version="1" fragment="single">KKSTVNKTIYDLKILASYLHIVIETLEISESPPFGLCNILCKFFGGVKKPDGSNYKPTTHGPEFVKLNEVFQARQNNSKVKAWEINIRGQTLLLKNKLKPDKGRIPGMYGQSSPRCGHVAQSQKKCPVAIYNEYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBR0</accession>
    <name>A0ABY7DBR0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_007568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ95097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="274" mass="27244" checksum="52AEF676C0072211" modified="2025-10-08" version="1">MAAAVLAPVAIKIGLGAGAGAGAGVGLGAGAGLAAAGSAGAGAAAASAGAAAVGVKVAAVGAGVAKAAAVGTAGKAAAIGAGAILGPIAIGVAIGGIGISLIFIAANSSKSSSNGGNTGGKTSNSHANKSDHKSKTNTANSNETPSSVTGGGGGGDDPRRRKNIPYLCQQNNSWYDDMVEDWETKALGPTNRRYYLYKGKWYSPDNDGHAGSAAKMYEPTGHDQTRPKTLKFQGSVDRNGKLIPKHESNWSKGQKGDINGRDLHGYKDRSYVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DET8</accession>
    <name>A0ABY7DET8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">FCER2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MAR_007410</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031569">
        <property type="entry name" value="ApeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324:SF33">
        <property type="entry name" value="MUCIN-5AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324">
        <property type="entry name" value="PERFORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16977">
        <property type="entry name" value="ApeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 9" id="KW-0420">Kringle</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0768">Sushi</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046722600" evidence="12">
        <location>
            <begin position="26"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="561"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="15">
        <location>
            <begin position="686"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="811"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="14">
        <location>
            <begin position="875"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="1050"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="733"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAQ94939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1305" mass="144931" checksum="9FA713564C232EB5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFB1</accession>
    <name>A0ABY7DFB1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="252" mass="29246" checksum="0D197786D9389212" modified="2025-10-08" version="1" fragment="single">MYQAKIITLLIEKEEYFLQLTEGISQLRGDLKSMLKKDEIEELIKNTVTSIFSKLEETMKKQIEIEITNKTKVLNDKITGLEFEKDHLKEELKTLEKKNSDMYTEMKSKIDRASETGLEALKLANYNEQYSRKNNIKVMNVKQAANETEPELIENVSKNLKSAADIDLNADNILAIHRIPSKQVRMDFQETKGTIAEKLPLSMRYIARLGAVSDTIRPRKEETVFNPRPPETSKVWQTVWFGIEPRSWCLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFC5</accession>
    <name>A0ABY7DFC5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="198" mass="22424" checksum="FA5A41D11177A5FE" modified="2025-10-08" version="1">MLFLAFGLISKWTFLEQHRNPARQSVPIPWEPPAFKKMGLELTFEGKILRHVAVGLFILTIVQLLLLLILALSWRIIMEPPPLESSMHCLICNNVSQPYPYNDLGNVIDARGQMYNESVCCDPIREVMERRIQNEMTKQFAENRQANPSHLVGESFITDCEWQGLKTPTAKLVGVVDSVPSDIVQGNHNTVNNVSVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DK10</accession>
    <name>A0ABY7DK10_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MUC19-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47202:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47202">
        <property type="entry name" value="HISTIDINE-RICH GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="648" mass="68876" checksum="1B4335497529AFAC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKE0</accession>
    <name>A0ABY7DKE0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KLHL6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_029847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF441">
        <property type="entry name" value="KELCH-LIKE PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="27"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ97157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="570" mass="64797" checksum="4BB502E92FBF1D9B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKT2</accession>
    <name>A0ABY7DKT2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DYDC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_028275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dpy-30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd22966">
        <property type="entry name" value="DD_DYDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049630">
        <property type="entry name" value="DYDC-like_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037856">
        <property type="entry name" value="Sdc1/DPY30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23356:SF16">
        <property type="entry name" value="DPY30 DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23356">
        <property type="entry name" value="DPY30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ95585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="233" mass="25844" checksum="8FE5839967057B77" modified="2025-10-08" version="1">MSWVKSSPGSLGRTSQSRRHQQCGDGGRVCWGPPATGSPSRSCPPLTWYRYLRTGAPARPSRGDHSCHPDLVGRNKRNMDTAYLKQTLGDSLSRCLSEVSEKRPRDPIEYISQWLYKYKKAEVEELEQQRKDYERDQLEEERAKKETTSPTKLPVVMEAQEPSEEAKAEAERAAEQQAAEEKAAAGGEETEGTKPPSEEPKPEDPPTQEPEGQEPAPDAGQEPATEPPAEDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLX6</accession>
    <name>A0ABY7DLX6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SYCM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_023035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF27">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="6">
        <location>
            <begin position="9"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="6">
        <location>
            <begin position="181"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ98662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="503" mass="58022" checksum="077AAFD338A8106F" modified="2025-10-08" version="1">MIAYSFVRYICGPTVYDSSHIGHASNYVRYDIIRRVFLDFFNINVSYLMGVTDIDDKIIVRANELGQDFTAITNHYEREFFQEMLALNILQPTMTSRVSDYVPEIIAFVQKIMEKGHGYVGKDGSVYFDVVEYGNYYKFASPQQLFKSDVEVKKNPADFALWKAAKPGEPFWDSPWGPGRGLDLMFPHHENEIAQSCSYHGVKQWANYWLHTGFLFTPQESEKMSKSLKNTISTSSLLSKYTSNQFRMFCMLTHYRNNIEFTEEKMQKAISLDNKIGSFLRQCDAYVKGQVSDTVCRCPGVIAAVEVHVKRICKKLGFLKKGWKMSEDSDNMKLREVLDHTVRFRYNVRQYSIKTKLPESDLKTSSTWDFDDSKDMREDSDWDSDSSGTPMDKQTTQETQSSEHGTSKEPISKEIMHDTQCGKTEEFEREMSTESPSIHDTQNRDYKISEEPTGRHTHDGQTTESEKLEQSLNVEDTCRKDTEKVDSKVLKEATESVSKRTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMT5</accession>
    <name>A0ABY7DMT5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_022836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ98463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="20085" checksum="7F6AEC44DE404205" modified="2025-10-08" version="1">MNIQRFTRTIKKAFLILMKKQLFLLNVIHYLIYSQYKSKNLNHKHNYAVIIALICEQFYFKRVNEIFLICVNAQLLEILFFSLGKINKLAEFSRHSQNICVLFFLKTLPVKNYNHSPVQQSVRNREVVEQDVNMYMVKLPVIIIHQYSNLLFKNSMRKKTYHKQKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DP57</accession>
    <name>A0ABY7DP57_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GLRK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_023021</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="5">
        <location>
            <begin position="38"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ98648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="351" mass="39597" checksum="024F8D297C9B98F8" modified="2025-10-08" version="1">MKLDIDDIDISNSHLLISKLCKHVAKGSIMMVADYNPLTYGSVQSYAHYLNVPTLVPGGTGSGVHGNYRYDVRLLPPTIDAISDVIKYFQWNSIVYYLFDTNDGDFYTPVIRPRRIANISDCYDVLRRIDRGKPPLRIVLDLSGREAYEQVLHQIVDVGMNRDGYHYVLGGLGIDELDLGTFVYGGVNITGFSIVDKFSTENAELISKAQEFTLHPVGKITVEKALVIDTIHVLVLAAQSLTEDATISINRGRYQSGETLQQTFDGEMVLRKLKNVKTYGLTGNIEFNEYGARQNYLFKVYQLELKKPLRQEEPFVQYKKNNDGNGAPRVDGKYLEVNYNSALDSHCVIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPT7</accession>
    <name>A0ABY7DPT7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046408212" evidence="1">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="62" mass="6975" checksum="8982D0A380847F86" modified="2025-10-08" version="1">MDGVLLAAVFIVFLWGSVVGGVEDDTFDSRFEYEYKVLKQLVVLEKETNELRGIMTTLTSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSS7</accession>
    <name>A0ABY7DSS7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="158" mass="18917" checksum="BBF53E46C61EF7C1" modified="2025-10-08" version="1">MDETVKEHEKKYECEHTMFNERYGVLAEETDGLSDYERTMAILKANDVHGFQIGISKLEELARLEREREEARQREAVILEHEREKRRREEHHRRELQRQQDELDALERRRASRESLVFEDRMTDSPPASTPRRSLDSGIGKRKDTNYLFFLSPYHGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSX4</accession>
    <name>A0ABY7DSX4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd10229">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="511" mass="57667" checksum="4ACAE877B8EDF84B" modified="2025-10-08" version="1" fragment="single">MGTPVSTPKKQNGYAFSFAHSPLEIKANYWPDGSIKTPTVILLDPDGRFHSFGKEAMDKYSSLLHTKEHKQWFYFDRIKMVLYEKGTPLNLDVTIEDKEGKPMKAIDIFTMAIEYFVHQLVATVTDKNRLDGLNFTPSKDIHWMVTVPAIWNDKSKLFMRNAAVKGHMAPTFSTVTEGGTVDITVHELNEDNSLTELYPPTGGDFGGTDVDNRFLQLLNDIFGISLMQKFKSDCLEEFIEMMSEFEIAKRRFNGTGKLIMKFPASLIEMYEFESINTCEHALEAASLNESIEIKFGRIYINANVVKKMFQYSVNEISNAIRNTLNKVENIQKVVLAGGFSESQHLQLVLTETYGFKLLEVSSEPSGAVLKGAVLFGHTPGCIVARVCPRTYGVARMVKFRPEKPYSNPPDKKITIDGKDYCDGIFDIHIQKGTKVAVTERSDIKEHVYFRPSLFVSNIIVEVFASDSLDPKYVDEPDCEKIGEAVIEMDPMVKMRSKIMVKLVFGGTELEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DV60</accession>
    <name>A0ABY7DV60_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGD4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="41"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="277" mass="32033" checksum="5FF202A956180B46" modified="2025-10-08" version="1">MDESGLFYRESSRSTFYMKGEDCAGGKRAKERITVALCASMTVDKLPVKYCSNRTAWIHSWCFEYWVKSLDRKMRAGNRHILLFVDNAPVHPNITLRNNCTSVLQPMDAGIIQTLKLKYRKRQIAHVLSEMDRNSSQMGPEILRVFNILQDMYWINSSWNEVKAETIIKCFQKCGFGEKLSFSTSDHEESNQDRDDIDEDDIPLAVLRLSRDLFSQDFNTLADIDSNVHTCDNSMTDWGRPAPQILSEMRNSDETSSNFDDKEEEEYLRFGKSGFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWB0</accession>
    <name>A0ABY7DWB0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="59" mass="6521" checksum="6DECAF0DB3390791" modified="2025-10-08" version="1">MGEPPVLLCAAGDVTPESQRVSRCSWRTDSCCSYMCTLHGLSGGLYTFKLTCNRNFLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXG5</accession>
    <name>A0ABY7DXG5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_008262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43686:SF1">
        <property type="entry name" value="AMINOTRAN_5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43686">
        <property type="entry name" value="SULFURTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="198"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="356"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR01704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="819" mass="94244" checksum="6506DB12F44C94AF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E297</accession>
    <name>A0ABY7E297_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EHF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_009184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF190">
        <property type="entry name" value="ETS-DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="4">
        <location>
            <begin position="132"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR02626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="200" mass="23840" checksum="90D6A7CD47EE074F" modified="2025-10-08" version="1">MDFAEFEFIIKRSSTDEAVIDMFDHNMNYVLTGRRELDTTFESYEKTTSKDRTPQVEFGTQEHFERPLCGRFEDDKPESQKTSLMDISNNTVDRDDMLDAYNRISMCYDWMKKEPCELSEEPVSSFGNKMSSEIWEFLCDLLHDPHYNPALVRWEDRETGVFRLVKSRQIATIWGMQKGNESMNYEKFSRAMRFLEQMKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3M3</accession>
    <name>A0ABY7E3M3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_009956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR03398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="129" mass="13953" checksum="BAA07BAB405338A1" modified="2025-10-08" version="1" fragment="single">KGTFRLSKRTRNFETPFTLSLVLVPSESKLKRAGNDISGLSFTNLDQTIDVNSSTEVGSTVFTVETDDDDVNAVSMTSQSTLFQLDTTDNRSVVVMDCLTAGYQEVVSFQATDGISVVTASLTLDVLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3P3</accession>
    <name>A0ABY7E3P3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_009679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR03121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="304" mass="33224" checksum="C88326A49C3CB10C" modified="2025-10-08" version="1" fragment="single">MPQTTAQNIMVYHVPEAITTPTSTCSCGGGRRAAQVFVRCQLPAKRCLPGHVQRNNVERGHPSDVEAAYGVRLRGGGPVWVEPERRGTRGATTCTSRLPVPTSLSTPLYWNHRCIRPLGAVAASHSDLVPGNPRDELQERLRHRRRQDLSPTSAMPSTTVMKTKTTTAITSKKQTTRAPNTVTKKAITTTSRTTPTMTETNPPIRTPASKQRTQTVMSDLPSTNSETPAFSKVSQSLHHHEASETGDSLSVTVKAFVGVAAACVAVTLVLVGYLLHKWRSSRRRYSASLHSTNPLNEEIETRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6P2</accession>
    <name>A0ABY7E6P2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-transporting two-sector ATPase</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_019836</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="12">
        <location>
            <begin position="382"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="13">
        <location>
            <begin position="485"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="11">
        <location>
            <begin position="591"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="14">
        <location>
            <begin position="824"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR04467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="954" mass="105157" checksum="698FCAB2A732AA5F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8K0</accession>
    <name>A0ABY7E8K0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RALB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_010034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF83">
        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="55"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="2">
        <location>
            <begin position="241"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR03476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="346" mass="40179" checksum="C38D5CA4392292E0" modified="2025-10-08" version="1">MPKDKEEKERKKIAELRSRLHDILKVEYEDYDLRKWLKARSFDVDKAELMFRNDVHPVVKRYLTGGFCGHDKDGSPIRVELYGHLDMKGLMASCRRSDLEKTKVMQCEWTVQEWKRMGEKLGRRVDGLTVIMDMEGVTTRMMWRPGMQMYLHLVKVLEDNYPEMLKRLFVINAPAIFPILYKLARPLISDEMRNKIHVLGSNYKNDLLKSAKAAMFQRSTTKTCGRCTSRWGPSPSPPAPWAFRSEEYDMGFGVQLVQDSGKAHFLVPLQRVNSHLVAEDGAVVCDQPGTYKLVFDNSFSWTRAKKVYYEYDIIAVDADYVRSEISDLVEAGDWDTLEQKFETTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAQ2</accession>
    <name>A0ABY7EAQ2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18460" checksum="21EB22EF90BF37ED" modified="2025-10-08" version="1">MKMRQTVLLHSVIIMICLDWINTAVLRLQWRKTIYENYTDLAMLQCVDKNNKVSYEKPFLVKGESGWRATGVFDSNHFPPVGTQLGIVRQVSTVSTEESGEYRCHLAYTEGPPAYSSAKASVSKTLTLTGSSPSSSSVTFLPHVFGHVLCNLCCILLFKWCSSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAR1</accession>
    <name>A0ABY7EAR1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CNTN5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_021623</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF73">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="219"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR06254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="312" mass="35148" checksum="659002D6AE5C003A" modified="2025-10-08" version="1" fragment="single">MSFICPYLSVVSLILIAGLTCIILADPARVESFRGDNDTGEEWYIVNHGDEIQLKCLIDGDPQPEIYIKRNDEILASVHSGLELQFSKRSSCLEDNGTFTCYAKNELNMEIPSAPVYPLKYSPKLNVTATNGEDVILTFTVFSNPPPFSALWSFRQDTQQTPQYITKDIVYISNDNMTTDIRISRIRPDEFGEYSVTVHNTLGSISETFYIIPEGPPERPLNFVVKEELITNSTAVVAWTSSFNGGQLQTFYVFLRQVLTTNWFSANAGTYAINFTIIELIPGTKYEAKMYSSNFHGRSDETEIIPFSTIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBR7</accession>
    <name>A0ABY7EBR7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KANL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_021933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026180">
        <property type="entry name" value="NSL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029332">
        <property type="entry name" value="PEHE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22443">
        <property type="entry name" value="NON-SPECIFIC LETHAL 1, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22443:SF18">
        <property type="entry name" value="NON-SPECIFIC LETHAL 1, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01300">
        <property type="entry name" value="PEHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEHE" evidence="2">
        <location>
            <begin position="820"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="979"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR06564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1034" mass="114973" checksum="A3FECC494CF5A09E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EC60</accession>
    <name>A0ABY7EC60_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="331" mass="35684" checksum="CCB48E44F9647D3C" modified="2025-10-08" version="1" fragment="single">MGNFLSRLFRGKSKGAPESAPASASPDHQSSSEATASSAPAISITEKKESEERHGQSESKINTKKMTSVDAVKQEGEMQSDAERSSTPLAVEAVEIALAITQELPQEEPVQILEQAKSDTAAEQQQAATAEAVEHNAETGQQKEETGAAQQEVTALVAEQQETAESTQQENNVEETVTQEQEQVAAPVAEQQETAESKQQEIQEEETVTPEQETTQESAPEADQQSIPVIQVGAEQPAIEQAETDQQEEETGVAQQEVAAPVAEQQETAESKQQEIQEEETETPEQEATQESAPEAVQQSIPVIQVEAEQPANEQAETAKTQEQTQDGSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECF3</accession>
    <name>A0ABY7ECF3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TUTL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_022001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="594"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="116"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="198"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="490"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="705"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR06632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="758" mass="83923" checksum="4080309B8A1B8333" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDY0</accession>
    <name>A0ABY7EDY0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TXLuncharacterized</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_017213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the taxilin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127:SF13">
        <property type="entry name" value="GH01188P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127">
        <property type="entry name" value="TAXILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="589"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="638"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="659"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR07255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="701" mass="77934" checksum="B4B8E2BEDB2BCB36" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEJ1</accession>
    <name>A0ABY7EEJ1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="715"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="869" mass="97622" checksum="19FCBA39F057F105" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFC7</accession>
    <name>A0ABY7EFC7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="122" mass="14070" checksum="0DBA407A7B41BF91" modified="2025-10-08" version="1">MFLCDERIVALKEASGMKVTKAASEMVVYERMQNIYKRACNGEMDASKYMGKGTSRMYNFILKELNIPFYCGQPAIDTWLGRLLKAVQSRSVEDVLLDIFTALYITRYANLDKDRSLDEYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHF7</accession>
    <name>A0ABY7EHF7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="87" mass="10239" checksum="4290DED83DDC354C" modified="2025-10-08" version="1">MDLKPIGDGWSFNTLERATAVGQSTYSRALNRKVEWPKPLPVQNAEKNFHKCNPPREQQETAQIHCNRFHTGRYPITYKAHRYLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIH5</accession>
    <name>A0ABY7EIH5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CCR4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF98">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="593"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="918" mass="100241" checksum="E57E0E10A7726AE9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIL0</accession>
    <name>A0ABY7EIL0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MUC6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_034908</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF386">
        <property type="entry name" value="HEMOLECTIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="4">
        <location>
            <begin position="250"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR09832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="333" mass="36809" checksum="7700268255EE5D8A" modified="2025-10-08" version="1">MRDCACWFKGLCGTYDGDQTNDFTTDTGNVVTQAPAFVTTWKRSFAGVQTCADLPQTGCNAATPQAVPPAAYISACKEDCCDSSGQDCLCSSFEAYSRACLEHNIRLDWRSDNRCQTCSRSPSYRVAGPGNLSKTFQSLITFGALISLYTLSTPCFRSPPDAQCPGNQIHKECGSMCQKTCQSPSSACEDHSCIDGCFCPDGMVLLNDQCVQKSECPCMLNGVEYRNGEQVPKDTCMNGAWQCTNKRCDATCSAIGDPHYMTFDGKRYDFMGVCSYYMIHDPGTFDIIVDNIKGRVLLHQESQYRHQWTPYQDGPQPPAVRGRRGNYQDSARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELN0</accession>
    <name>A0ABY7ELN0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="137" mass="15123" checksum="3A95126459115EBE" modified="2025-10-08" version="1">MYRYQAVYKTDIWQEASGRKIFEVLFVKATCEGVKAVAEHGIRARTVFAASKSVPTKAAPQVGQTLARNTSVSRGAGKIASKSSRLSKIVDKFGTGLRICYEVWCAGNDIYKYAQQRDKGFISGSHANQLLTERNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELS4</accession>
    <name>A0ABY7ELS4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_019292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="554"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="707"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="871"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="941"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1092"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="471"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="710"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="875"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="941"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="952"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1125"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR09334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1320" mass="146762" checksum="172345AEE51A123E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMI1</accession>
    <name>A0ABY7EMI1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">S4A8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_035012</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003024">
        <property type="entry name" value="Na/HCO3_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF36">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01232">
        <property type="entry name" value="NAHCO3TRSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="720"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="780"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="808"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="852"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="875"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="12">
        <location>
            <begin position="35"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="11">
        <location>
            <begin position="362"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="11">
        <location>
            <begin position="662"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="932"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1071"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1080"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR09936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1092" mass="121715" checksum="915A753CCD983309" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMK2</accession>
    <name>A0ABY7EMK2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="618" mass="69697" checksum="5F2965E4E5F36AF1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMW8</accession>
    <name>A0ABY7EMW8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CSMD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_018489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050350">
        <property type="entry name" value="Compl-Cell_Adhes-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325">
        <property type="entry name" value="COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325:SF575">
        <property type="entry name" value="LOCOMOTION-RELATED PROTEIN HIKARU GENKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 5" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046408227" evidence="6">
        <location>
            <begin position="18"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="65"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="122"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="180"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="238"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="296"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR08531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="377" mass="38451" checksum="9F37F9669F64E83D" modified="2025-10-08" version="1">MMLLLWISLYFLHVVEGQIGVTTCTDTSDCASLSNSLCDTIVTQTCMCVSSQGYTANAANDGCDYDCGSLSNPANGQVSAPTTTEGSTATYSCNSGFILVGGSARTCEASGWSGSEPTCQQVDCGSLSNPANGQVSSLATTEGSTATYSCNSGFMLVGDSTRTCEASGVWNGSEPTCQQVDCGSLSNPANGQVSSLATTEGSTATYSCNSGFMLVGDSTRTCEASGVWNGSEPTCQQVDCGSLSNPANGQVSFLATTEGSTATYSCNSGFMLVGDSTRTCEASGVWNGSEPTCQQEDCGSLSNPANGQVSAPATTEGSTATYSCNSCYTLVGDSTRTCEASGWSGSEPTCQQDSKADALVISTWLAVASTILVVAMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENM3</accession>
    <name>A0ABY7ENM3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CCAPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_035901</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052665">
        <property type="entry name" value="Neuropeptide-GPCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001817">
        <property type="entry name" value="Vasoprsn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24224">
        <property type="entry name" value="CARDIOACCELERATORY PEPTIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24224:SF6">
        <property type="entry name" value="CARDIOACCELERATORY PEPTIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00896">
        <property type="entry name" value="VASOPRESSINR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="17"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU046427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR10825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="331" mass="37066" checksum="3A59DBAA406F50EB" modified="2025-10-08" version="1" fragment="single">TEQLMFLCILFVTIVVGNFLILAGIVSSGKRRSRMNVFIINLVCADLSVGCLLVLTDIIWKVTITWYGGYIGCKVVKFAQCVATFGATYSLVALSIDRLDAIARPMNINNVERRCRILVGLAWFFAVLFSSPMLYMSEMDIVDGKEQCWIDLQPWVWRIYVTMVSFAVLIIPAIIIASCYIAIVVVIWSKSSKFKSPDTRRCAEKSSLSKSGSITVRFTGSNRHSKAAMGASSSRGVIPKAKIKTIKMTFVIVLVFIFCWAPYFIWDLLYVFGHIKMSQRSIAISTFIQSLAPLNSAANPIIYTLFNTAIFTGMFKKRHAYNSPPHTPRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERB9</accession>
    <name>A0ABY7ERB9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">TLR4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_034807</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017241">
        <property type="entry name" value="Toll-like_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037595">
        <property type="entry name" value="Toll-like_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046683314" evidence="12">
        <location>
            <begin position="23"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="13">
        <location>
            <begin position="695"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR09731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="837" mass="96430" checksum="C36B64A0E8B391E6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERU7</accession>
    <name>A0ABY7ERU7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="444" mass="48264" checksum="A27AC6D184D87E5E" modified="2025-10-08" version="1" fragment="single">PSPKPPKAEEGKPEEKEVKPEEKEGKPEEKEGKPEEKEEKPKEEEAPKPEPVKPRKPGGPGAIGFGGNILAQLKEKQEKRISMAPKQPVVTDKSKNPVVEEKPLPFGLPKLRPVSGAKDSDGGPTKKETKSTDSVKSSGSKSETEEQKPAVKDSGIADGEKPSEKLKKNFFKESKDKPSVVPRPGFSGRPPPPMKPKPPGGKPTPAPRRSTADDQDEPVKEPKKMEQNSKKPEAKKVESGVVYDSATLKKSVREKMSMFSSSGDGDENEAKNNSLLTGSYKEEHSRKGISSPSLSGKSGSLPRDTKPFDVTKSQMHDKSSHNDATPGSEAGDTAFKREHNSNDMTDSGIVYDSETLARPSVKDAAAVFGQADKSEKSSSLSRKAKPSDMKESPEVTRRPKSMFEVLQNRPDLKKSGTLDTPLEKEENKETVEEKGSPTEDVILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETB3</accession>
    <name>A0ABY7ETB3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATMIN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055303">
        <property type="entry name" value="ATMIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46664">
        <property type="entry name" value="ATM INTERACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46664:SF1">
        <property type="entry name" value="ATM INTERACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="655" mass="72315" checksum="C309F947D365E1A6" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETT3</accession>
    <name>A0ABY7ETT3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ANPRA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_027548</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052612">
        <property type="entry name" value="ANP_Clearance_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755">
        <property type="entry name" value="NATRIURETIC PEPTIDE RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755:SF8">
        <property type="entry name" value="RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="6">
        <location>
            <begin position="22"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR13368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="337" mass="38463" checksum="6C1D6AB57BC2FC78" modified="2025-10-08" version="1">MHPLLVLSDVCEYTVSLGPIRDSISAIMSEYNWFHTAILYDISYVFFDLAGSNLVHDFRTNPDMERPYDIAFNPSKVTDYGELLLEARNYARVFVIFCDSDVLRTVLYRAHQLGDEKDAAVTRAYESLLLLTLRQPDNAEYKTFAEQVKIRAKRDYGYEFGPEEAVNYFITAFYDSAIYLALSYRAVLDDGGDIRDGNLVAQRLWNTTFQGPVKVDEVGNRVADFDLFHMKSPDTRLFERVGRFRGATQLYAPTTDVYIQWPAGLPVDRPPCGFTGELCILVTDDQTMLIIVLVVTLTILAVIVTTAVILLYRCRCCRTGTLRSLWGRVWNQVTWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUW5</accession>
    <name>A0ABY7EUW5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_026912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047509407" evidence="3">
        <location>
            <begin position="25"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR12732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="321" mass="36037" checksum="A6732C8F21BE0D8C" modified="2025-10-08" version="1">MGILSRYALVLLVILMLQRRGASGTPVSMLVQWLSPRSWADSFTEEKDTVLSVVAMVPFGSIITIAAVKHDSIENIATFTTNSSADDMLLGILHEYDTTENSIFVNTSLMRKNVHETFPQHGQQMAEIVVIVCSDVTLMGPVSSILSTETLKKTLVVKVGDFRSVDPWLDVATDADHVLFASEHDKLMKVLQKDFLHFVKQQQQKETSTKNEQNETKQSFVYQDSKLLTISVVVFILVLIAVVVAVVVVAVVAILAFKNLERLRRFITWCTIAIRPLRGEQNIEMVQKSQQSDQSPNNESETAETRLLGKKNLRQRDKMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVB8</accession>
    <name>A0ABY7EVB8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="221" mass="24223" checksum="240E480E1CF653EB" modified="2025-10-08" version="1">MSPYVLRNPFSRPRTSLEASCGRFPTIGKSGGPGGTPRRRLVARQSDVEIWTECPQCQHVGINTMNIPEPDQTFPGVGVLEDAACRDDLTAATECTSNFEDACETMYMSLVATGMKKGSPGGAVESKTIVRMCTYMIHNTTMNTCERVDMSNSTEPSIVQMFKVLRIQFENVNMTADTCTGAAAKPAWYDVDHLKDIQPNSADRPAVRLLESSRCGVEQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVR8</accession>
    <name>A0ABY7EVR8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GBRL2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_027570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd17163">
        <property type="entry name" value="Ubl_ATG8_GABARAPL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR13390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="221" mass="25474" checksum="A9D164C4CD823E54" modified="2025-10-08" version="1">MTQKKVYKLTEFRKRFIEIAREDFGDNEVACGTCATRKPINKPFPTFEPVVSLEEVKPTVTPAFWPMFSVFDDLSDQSVFPPWDVLHAKTMFEATASVSNVAFNPIIMATSTDYNQRKAESTKIRDKYPERIPVIVERDPKSQIQDIDKRKFLVPNDISVAQFMWIIRKRIQLPSEKAIFLFVEKVLPQSSASMGQVYEEHKDEDGFLYIAYSGENTFGHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXX6</accession>
    <name>A0ABY7EXX6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="126" mass="14526" checksum="B75FAAEB4C126975" modified="2025-10-08" version="1" fragment="single">TRLQVSSIFLLCQPDVYPSLYTETERDTRSHQRAHRHDTVHPFQGGKFGVNFWVLAESTTGYVISYTVSRYDCKTITPVYRVHIHVVKSLMSACHFLGRGYHVVVVSFFCSLDLAKHLMQRNTYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EYG3</accession>
    <name>A0ABY7EYG3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057496">
        <property type="entry name" value="FAN-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF123">
        <property type="entry name" value="PROTEIN FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25400">
        <property type="entry name" value="PH_FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH" evidence="2">
        <location>
            <begin position="82"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="453"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="550" mass="62715" checksum="47E1114988C68F1F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZB1</accession>
    <name>A0ABY7EZB1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DI3L2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="36"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="104" mass="11799" checksum="A12D159605ECCBE4" modified="2025-10-08" version="1" fragment="single">MLIENGVDFEEFPQQAIDCLPQNLPWSIPEEEFEEREDFRKCCIFTIDPATARDLDDALSCEDLGNGRYKVGVHIADVSYFVEEGTVLDNIAGLRSTSVYLVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZS3</accession>
    <name>A0ABY7EZS3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="111" mass="12434" checksum="19317C3A017520F9" modified="2025-10-08" version="1">MIYRPGTAICPTVGFNTSMIYRPDTAICPTVDCNTNMIYRHDTAICPTVDCNTNMIYRPDTAIFPTVDCNTNMIYRPDTAIFPTVDCNTSMIYRPDTAICPTVDCNTNMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0X1</accession>
    <name>A0ABY7F0X1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="75" mass="9315" checksum="04B5E1AB2C097E9B" modified="2025-10-08" version="1" fragment="single">WIKHLLLKALQWVKAPQWVKKQLLKALQWVKKLFLRALQWWVKKQLLRALQWVKKQLLRAPQWVKKQLLKALQWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F142</accession>
    <name>A0ABY7F142_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S35F6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR14464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="220" mass="25197" checksum="EA081F40B20399DE" modified="2025-10-08" version="1">MDIVSSYSGCGHGCHRIHQHPFNQEHPVLDENPPRKFNPFVFLPAALCDMCGTSIMYIGLNLTFASSFQMLRGDLLIIMAQIIAAVQMVYEERFVTRYNVHPLAAVGWEGFWGALSLGLLLIPFYYIHAGNFSNTAGHRLENVPDAVTKELSATTRMVLDSVRTLVIWMFSLAVKWQDFQWLQEGKQLTEQDRHNSRADEREEERQRLIRQLDVADNQCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F188</accession>
    <name>A0ABY7F188_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="392" mass="43873" checksum="AE25F4FA00ACA42F" modified="2025-10-08" version="1">MSPASHLLLNIDNPFLAQMVTNIYPPELALNKANRFDKTVDCKNRVSATDVKTEESVAATETLVNGLLQAIGEIDPRFKTSCIYSGSFYDDLKVGQADEFDFVARIESLSQEGILEAKRSERKKGFVYLVVKDKQTIERFKEFITSPDDDECLQHGCTVEPISLISDEGEYDESESDTDSYESDESEDSRSNEETIQGASTMGAEQVDPSDCTYKLHKPDVPAMKRKKEHDTDVVQNIEVVYDRPMKTAFPEDRSWEPDQLSSLLKTALNASDGCKSTSKRDDTASKATPRDKERIHLEGHSQRHGEDTVTKATPRDRGRIQLSRPLPETGGHSQRQGEDTASKATPRDREDTASKATPRDKGRKQLAMPLPKTRERLQLARPPPETGRGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4Y1</accession>
    <name>A0ABY7F4Y1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PGCB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_031246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050828">
        <property type="entry name" value="C-type_lectin/matrix_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45710">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45710:SF26">
        <property type="entry name" value="RH26557P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046289764" evidence="1">
        <location>
            <begin position="21"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="99"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR16652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="244" mass="27708" checksum="08E7C1E1F424EDFC" modified="2025-10-08" version="1">MEHFEIVLLLSMSMWLCAFSVDFLKFSKLNKDVTADVVITFQCGNIGTCLAKCKRFDVNYDAVRYVNGLCSLYRDVVVLGTDYTGSGETYLRQPVRTQFGSSMYLSFSAERSWQDAQNTCELMGGHLVTITTQEENNFVLGLRVDPLSDTWVGANDLSVEGNFTWITGEEWTYSKFTNADGWNGSHDDTDCMLIKRDQFESPLFSNKFDDAYCSRLKTRLHNSRFISDTFYILESQSSIPLSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F6Q5</accession>
    <name>A0ABY7F6Q5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PTPRK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_031085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="68"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="217"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR16491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="291" mass="33003" checksum="7201E038C712D8E5" modified="2025-10-08" version="1">MDLLTREGEAEGSVNIHGCVTNLRHRRTRMVQTADQYAFLHHAIVHTLAFDSKPVQTEGFATYMSDSKNKQRLIKQFKQLEITMERSEEERQASERNAALTKSNREGADIPGNLYRPRLHLGKEPGHDYINAMYVNEKAVCIVDMESECSLYIPDLGTQKQFGSYTVDNLRQMSTPYSINRVLRMSYNGLRGPNEHTVSHYEVTAWQDNVKVPESATHFLQLVKEVETKAASGSAIMHCKTGGGRCGLFAAVWTLLEKTGIEHEVSVFNTVRQLRARRPNAVRTRVSAYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F738</accession>
    <name>A0ABY7F738_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Prolyl endopeptidase</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_032549</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="9">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="9">
        <location>
            <begin position="175"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="370"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR17955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="438" mass="49061" checksum="34A13CB187222C12" modified="2025-10-08" version="1">MERALPGIGLMPRPPWKWSRAPSLVPGGPYRDASVSRVDPSERMFENVSEFSLLNPSGHINHQTEIRVLPTGLSLEDLASLTSSTAAVEEFLILFFVPKIPDPYQWLEDPDSEETRAFVDAQNARYPEGDGKADGTETTSNLHQKLYYHVLGTKVRRLYFTDLSLLIGGIDGLVPFVKVVDNFDAEYEYITNEESLFTFKTNLNSPNYKLINIDFSNHAMEHWVTLVPEHEKNVLEWAACVHGNRLNQLYVHELVLGSQLCHLPLEVGTIVGYSGKKKDDEVFRDIKVKNFQFEEFTTDQVFYTSKDGTKIPMFLVHKKGLKMDGNNPVMLYGYGGFNISITPSFSVSRLVFLQHLGGVYAVANIRGGGLIINGGSNGGLLVGACANQRPELFGCAIAQVGVMDMLKFHKFTIGHAWTTDFGCSDDPEQFKWLIKLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7J3</accession>
    <name>A0ABY7F7J3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="185" mass="20919" checksum="A7B3D2CD3A9F661F" modified="2025-10-08" version="1">MKQMGDEDINGQFQELQNVLGKTSNNEMHAVEEKREIKGNIRPFPDIPDAFMEYIAADRNIPCLLLNSTPGASGYINAVYIDKPNVGFYYPADNHILKEGMFQVSCSRSVPHFGFNAWDNTSDVPKSSKDFLDFIRSVDATLRETSTRGPEQFEFCHECVLSYVKSFEYSQYANFTTSIASEPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7Q9</accession>
    <name>A0ABY7F7Q9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="140" mass="15671" checksum="00BC48028F4D6A68" modified="2025-10-08" version="1">MLKRWKVAGNCAILMFLVMTVLVYMFCLNKGLINYGFKYNQLNTTLTLINNDVAEPSAKSDTPTVAQNITKAEYSSTQCKHRQVKLSERRLPLTGLLSFPGSGNTWTRHLIQQMTGTVNIPVEKGFAAEKRLMTLSKTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F883</accession>
    <name>A0ABY7F883_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_031595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046172765" description="protein-tyrosine-phosphatase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="487"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="850"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR17001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="957" mass="108059" checksum="E221BEE66A64F432" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCN3</accession>
    <name>A0ABY7FCN3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="119" mass="13434" checksum="E5B0D2D19801AF47" modified="2025-10-08" version="1">MGVTVVVDWTGWDQFAVVDRVKRMLQTVPMAGEVLDARALHKSAQPPTTPPSVGGENQKANYYICQLINFSSTQRIPSTVLTYFNSASYIYSFVWRKNSDGWLSADELDTSQTFQIHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDC0</accession>
    <name>A0ABY7FDC0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="212" mass="23013" checksum="193D6BC0AB3BA313" modified="2025-10-08" version="1" fragment="single">YRSKPCNAILVTCYNACACVERDVTPGLSAAASSGAVNLVLCGCEERRIELEGVRMELLDCVFPSLTSILVIGFVKFNIFLPNLDFKDLDGVLHPNMSEKEVDTYDVHGPLSAATAIARFLCDAHQSSLATHSQSRSSVVGIDLREEAEYGCPPDRQVESCIAATCDHHFNSCGSQGPRVLLAIPRRVGQADTRTTDTDDPIYANASLYSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FE58</accession>
    <name>A0ABY7FE58_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="74" mass="8903" checksum="959D12869A3D4F7B" modified="2025-10-08" version="1">MVHSKDQERCEQNKECMYTECRQCKEKQLSCENADGKHRNQRIDKEKDGKKKVVNKTVKENSPRHKRNISRRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFJ0</accession>
    <name>A0ABY7FFJ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="77" mass="8684" checksum="74A67B007F9CA2ED" modified="2025-10-08" version="1">MDAFIRWYTVYMGQSTTLHASQQTDDLSRVMFIFQLLQSGLIFTALVAGAISIEVTITELKILSNKECNVSVFNYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFN8</accession>
    <name>A0ABY7FFN8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CALM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_001376</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR19538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="237" mass="26661" checksum="B783FD485934F8B3" modified="2025-10-08" version="1">MEPLGQAENKTDETKDRLCVPSDEIDEIVDKETNVENDDGEEDLDPHYCLTETQRTELDLNEDTVKAIRDVFTVLDQDKSGSLDVGELETAMRQMGVECTHSEIVELITQIDKDGNGTVEFYEFSRMVAEKLQAGDPETELKEAFAVFDKNGDGKVSSEEIRVVVESLGGKMTNAELENMLREVDENNDGYLDYEEFVHIWMGDEKPESERRQASGTSTTEETGGVLPRETTRPSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFU2</accession>
    <name>A0ABY7FFU2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1065" mass="118504" checksum="2969C393EB990FC4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FG28</accession>
    <name>A0ABY7FG28_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MAR_015107</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX4/VASA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX41 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd17951">
        <property type="entry name" value="DEADc_DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044113">
        <property type="entry name" value="DEADc_DDX41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="134"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="329"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="14">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAR21133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="507" mass="56194" checksum="BC3031DA79C4E98A" modified="2025-10-08" version="1" fragment="single">RHALKDASDESDDDNYVPYIPLKQRKKQQLRQAEKRLGRVGLLKEQEGGSTSEGGTSEGGAEEDEDETVNLGPKSHVSLLDQHSDLKRKAEARKETAREKILKEEEKILESVAEKQALMAVSELAKGIEYTDPIKTGLSGRDMIGIAFTGSGKTLVFTLPIIMFALEQEKRLPFVKNEGPYGLIICPSRELAKQTNEIITEFCGHLERDGYPALRSALCIGGMPMNPQLEVIKRGVHIIVATPGRLMLMLSKKMFVLDICRYLVLDEADRMIDMGFEEDVRTIFSYFKGQRQTLLFSATMPKKIQNFARSALVKPVTVNVGRAGAASLDVVQEVEYVKQEAKIVYILECLQKTSPPVLVFAEKKQDVDAIHEYLLLKGVEAVAIHGGKDQEERTQSIDQFRKGEKDVLVATDVASKGLDFPDIKHVINYDMPEDIENYVHRIGRTGRCGKTGLATTFINNGVGEAGCMYCGGLGHRIANCPKLEALQTKQVAGLGRRDYLAASSADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJ72</accession>
    <name>A0ABY7FJ72_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Suppressor of fused homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_016222</name>
        <name evidence="6" type="ORF">MAR_016622</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUFU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.230">
        <property type="entry name" value="Sufu, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020941">
        <property type="entry name" value="SUFU-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024314">
        <property type="entry name" value="SUFU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038489">
        <property type="entry name" value="SUFU_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037181">
        <property type="entry name" value="SUFU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007768">
        <property type="entry name" value="Suppressor_of_fused"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016591">
        <property type="entry name" value="Suppressor_of_fused_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10928">
        <property type="entry name" value="SUPPRESSOR OF FUSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10928:SF2">
        <property type="entry name" value="SUPPRESSOR OF FUSED HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05076">
        <property type="entry name" value="SUFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12470">
        <property type="entry name" value="SUFU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011844">
        <property type="entry name" value="Suppressor_of_fused_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103359">
        <property type="entry name" value="Suppressor of Fused, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suppressor of fused-like" evidence="3">
        <location>
            <begin position="61"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Suppressor of fused C-terminal" evidence="4">
        <location>
            <begin position="250"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR011844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR22248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR22648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="469" mass="52388" checksum="7181E8C2F360CE1B" modified="2025-10-08" version="1">MPYNQANMDERDNYFAPNYQNYQVPVTPPGLEAIYSACRKLYPDQPNPLQVTALVKYWLGGPDPLDYISMYANPGDPDKGVPPHWHYISFGLSDLHGDGRVHECQGTDGPSGFGFELTFRLKREPGETNPPTWPATLMQALARYVFQTENKVYSGDHVPWHIPLDGSESRVQHMLMADDPSLHPITTPFGPVCFVQIVGVCTEELQAAQHWNGPGVIELLRSISQAGGPWLITDMRRGESIFEIGPTLQEKVDSGIEQEGSNLSGVNSKCSWEEPGENDRDSLSFKDGIVDDDEDDAERGHISIIESDQIKSTLSRGLDPHLQSKIDGFNRPRSRKGSFDSVESSDAPTELLRTRTLEFVHLKFNLEAASLLPLALRGRLRHGRHFTFMSATNDSAITLVSPSVNGSIADEEHPFAAHGLWLQVLLADDFIEEMCIDLQELSNPADLLLPKTYRWPERRLCITILPDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FK80</accession>
    <name>A0ABY7FK80_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_016541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR22567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="192" mass="21948" checksum="00B5C8B2C334B14B" modified="2025-10-08" version="1">MCTRKDLEEVASQMVEKFKEQLLIDLKDESTKIVDSKFNDLKTEIAEIRKENQHLKECIASANEARDELEQYGRRSMLEIHDEEKANALNNYFSSISNVNDSSSTLPRSNLKTNYCLNELTINEQEVIDILENLDVNKSTRPDQISQRMLKETSKTLGYRDHEGSSPRKRPSHCTSVGLTPAIATNVGYSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FM48</accession>
    <name>A0ABY7FM48_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047234204" evidence="1">
        <location>
            <begin position="21"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="225" mass="25477" checksum="815F81F6CE860C5E" modified="2025-10-08" version="1">MTAFISFLTVASMCLHSVLTAPHTGGDVTIPIRSRRHVALLPPYHNVCPSPSSERVRIGQAVSMETIFDKTMEFKQKLGIEINQFKRQHISCGATLTYLDSLTLEHFVHIQQPSFDAENLIFEEYMRLSVVEYLIKILTSSQAQECCVAVPDVHHHLRHRVLSKWRQHVSVGDTAVLEGSCLIRADVVVNLGRDCSDMRNLVYVLLRHVEREIDGSILTLDFLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FP75</accession>
    <name>A0ABY7FP75_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TMP2L-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF12">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRPM SLOG" evidence="1">
        <location>
            <begin position="9"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="125" mass="14142" checksum="91540EA1CCD55F99" modified="2025-10-08" version="1" fragment="single">TTGGSEPVQYKPVESDKRYPLDPNHTHFLLVKGRKTTEFGYGVDLEFRHKLQNCISETETDDYRMDIQNVTILIEGGLSSCKFMLEQLKSGIPVVVVKGTGKASDWMAYAYEHSREDKAKPNLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQA8</accession>
    <name>A0ABY7FQA8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SGK3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_036580</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd05575">
        <property type="entry name" value="STKc_SGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="88"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="346"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR22911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="423" mass="48070" checksum="4ED3BE381E704132" modified="2025-10-08" version="1">MQVKRLYPEANLRLPGKKIFGNLDPEFIQQRREGLDDPEVKSFLSLDNPRNAPDDTDLSPETSDTMSKDSNPINLGPSEKKSVKPSDFEFLKVIGKGSFGKVLLARHKNEGGVYAVKVLQKQAIMKRNEVKHIMAERNVLLKNIKHPFLVGLHYSFQTPDKLYFVLDYVNGGELFFHLQRERYFSEKRARFYAAEMASAIGYLHSLNIIYRDLKPENILLDSTGHIVLTDFGLCKEGIEGMGTTTTFCGTPEYLAPEVLRKQPYDKTVDWWCLGAVLYEMMYGLPPFYSRDTAEMYDNILYKPLRLRTNVSAAARSLLEGLLQKEKEQRLGSKRDFQEIKTHSFFADINWTDLDAKKIDPPYNPNVSGQLDLKHFDPEFVREPVPASVGKSPGLNKLVSASVMEADGMFQGFSYVPPAEDAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRN2</accession>
    <name>A0ABY7FRN2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RAD17-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_038557</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR24888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="421" mass="46257" checksum="0E7B402B185FD327" modified="2025-10-08" version="1" fragment="single">MLAYIKVPPILLLTGPAGTGKTATIRVLARQLGCEIHEWSNPLPGDSYDSSASNDDWRSRSRVEAGISGSQSAQFKEFLLRANKYNTLDIFGGGGISTTRLILVEDFPNMFYRDATAFHNILQRYVQVGGSPLVFIVSDSTSGESTERLLFPRNIQDQLNITNISFNPVAMTSMTKFLTKIVTEESQKGSHRFTIPSKAVIESIAMASTGDIRGAINALQFACLKDTCDLASAIGSKSKPRGGKKSGSQRGGGMKKSLSKKSSFQREEDFLSIGGKDTSLFLFRALGKILYCKREEPPADSPSLPPHLAHCYRDPLQIVPEEVVERSHLSGDYFGAYLHQNYMEFFSTIEDAVTASEYLSDADYLTIDWASRSALQQYAASVATRGIMFSNSTRARHTDSGGGGLGWKPLHKPQWYTASKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRS4</accession>
    <name>A0ABY7FRS4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MAR_038389</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">MELC-2E11</strain>
            <tissue evidence="19">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00108">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 14" id="KW-0420">Kringle</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Kringle" evidence="17">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="246"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="436"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="686"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="793"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="908"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="1066"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WAR24720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1197" mass="135674" checksum="0834AC35C8EACF6A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRS5</accession>
    <name>A0ABY7FRS5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGRL2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_038597</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF347">
        <property type="entry name" value="FI21270P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16489">
        <property type="entry name" value="GAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="709"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="781"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="866"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="916"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="10">
        <location>
            <begin position="527"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="11">
        <location>
            <begin position="707"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="134"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="955"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="955"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR24928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1003" mass="110222" checksum="EF8F7D7A9CEF77F4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FS92</accession>
    <name>A0ABY7FS92_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTG1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_010731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033332">
        <property type="entry name" value="BTG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978">
        <property type="entry name" value="B-CELL TRANSLOCATION GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978:SF22">
        <property type="entry name" value="BTG FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00310">
        <property type="entry name" value="ANTIPRLFBTG1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-proliferative protein" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="173" mass="19532" checksum="7460DC5BDC08168A" modified="2025-10-08" version="1">MKDEIKSAVDFLTNILRSRDNVNEKQRNEFNTILRNLLSARFQGHWFPQNPMKGSGYRCIRLNHNMDPLILQAGETCGLNCAFLESTFPRELTIWVDPRDVSFRIGEDGSVGILFQSENTSSQLATSDLSPIHHSNKNLSSTLMSCKDQFMNALPSLASESLHYKQFAGFVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSJ2</accession>
    <name>A0ABY7FSJ2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BAKOR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13664">
        <property type="entry name" value="BECLIN 1-ASSOCIATED AUTOPHAGY-RELATED KEY REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13664:SF0">
        <property type="entry name" value="BECLIN 1-ASSOCIATED AUTOPHAGY-RELATED KEY REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR23691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="387" mass="43106" checksum="C92E19BA8F824B56" modified="2025-10-08" version="1">MEEISCSDTEAPTEFNTKSISQSLSGLSVAVERCPLCSEARRPFYCKGCVNEGQFHHSTARYPDSFKEKSAPEKKRRIIDYIVKVTDAIAKKREKLTERQGEVMELRKSRIADLTTYIFPVTAVKMERSTGAMGESDDVLKEALQEASQMAYVRGRWITASSSSQYKIVAPVLPSNGDYSQYNIMVAKAAEEGSREDTSHTSPGNTIIAGLCHTSQLLTLLAYFLSVSLYKKQCFSEFCLDEVPERQFNRSVSRLNKNVLYLCFSQGVSAERLEPKHTPHNLVELLNHSQLGRIGWFDVEQDMMDSVEDSNGQSDESDDDFNNCAKGELDSGDWETVPDNIPLPSAATQPESLQALGYVSQDMTESALTASSVLSSAFSTFGSYFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUC0</accession>
    <name>A0ABY7FUC0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SMC6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_037990</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="369"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="643"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR24321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="800" mass="91753" checksum="32221DBD9237DEA6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUY7</accession>
    <name>A0ABY7FUY7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Scavenger receptor class F member 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_038215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27538" checksum="55B71ED24686D9F8" modified="2025-10-08" version="1" fragment="single">LKRSCVSKWSLDVGCLGKCKPGYFGQYCEETCSKECLKKACNKSSGICKDCTRTYLEGCTQECGQGCREKDGFPRCDRKSGKCLNGCVFNHYGNFCNVSCRNCKRNSSVVLCDSNGVCLYGCENGYWDKKCNSKCSANCESNAYENRCNSSTGECLNGCTRGWSGLFCGDTMEERHYICEQDNMNEVNPRRSVVESDSSIELNAARKSKKEEGLFGDLGQFQVDYIHAIAREESDNKLGQHTMESPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FV94</accession>
    <name>A0ABY7FV94_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FIBA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_011832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF5">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="5">
        <location>
            <begin position="46"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR26128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="257" mass="28846" checksum="61CF27E827F7EB22" modified="2025-10-08" version="1">MHLSLTYHIDGSSLRQNMLLLLSLLAVGSLGSIKCILLGDETALNVGDVVQYKDCDDILKSGKYQKPGAYLVYCDFGLNIVTHVIMQQKYGLVSFNKSYKDYDSGFGNVSEGDFWIGLQNMTKYTNAGYNVLTLTMQDWSNQTKVVRYNNFRLGTAAEGYRLTIGGYHSANSDLPDNLYHNNGARFATPDKPDTQNCATNQGGGWWYNYCTFTLPTGHYYSGGSYTPPASYYNGIYYKDWHGFAYSLKYIKMELSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWI0</accession>
    <name>A0ABY7FWI0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RMC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040371">
        <property type="entry name" value="RMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009755">
        <property type="entry name" value="RMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049040">
        <property type="entry name" value="RMC1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897">
        <property type="entry name" value="COLON CANCER-ASSOCIATED PROTEIN MIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897:SF4">
        <property type="entry name" value="REGULATOR OF MON1-CCZ1 COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07035">
        <property type="entry name" value="RMC1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21029">
        <property type="entry name" value="RMC1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Regulator of MON1-CCZ1 complex N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Regulator of MON1-CCZ1 complex N-terminal" evidence="2">
        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Mic1" evidence="1">
        <location>
            <begin position="319"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Mic1" evidence="1">
        <location>
            <begin position="401"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="544" mass="61706" checksum="1FB3F6C1C6E1F3F5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWS3</accession>
    <name>A0ABY7FWS3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TSP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_011032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR25328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="355" mass="38582" checksum="20A17FEF6646AF0A" modified="2025-10-08" version="1">MHYPSLVDGVWLPWSPWSTCSVTCGDGLVMRTRNCSFPDEHDHGQPCMGAATEENNCTVNQCPVDGVWLSWSEWSDCSITCGDQLGLSTRNRTCFYSPDQPLGDACPGATSDSKYCAAEKCPICKPFTVTDDAWRPCNGTHFLLTDPQKVATAQSAAVCWIKGGSIGSLGDGSAQEVNNIVSDCSLQNIFATGELYRIREPIDMCCSYLSMDQLGHVTIEQHSNCIDCPTKSFLICENKQPPRISTVFDQWYAITGSLQGILITSITDTHEACIHKCMSMSAKLAPIDLASALAPTILPPRDPSLTHYWMAESAAAPGQCRVVADSLHTRMQEVAAQSCETLAHCICQSQTSLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FX98</accession>
    <name>A0ABY7FX98_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="71" mass="7666" checksum="2F23F1C15C803D5E" modified="2025-10-08" version="1">MPLKSGGRSNACTLMQMPPQLGGRSHTCTENIRRLLHVGVRLLLAGLHIAVDNQGDNSYHKGAAADPRPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXB1</accession>
    <name>A0ABY7FXB1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DEN6B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_011483</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024224">
        <property type="entry name" value="DENND6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677:SF0">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR25779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="543" mass="61807" checksum="9A7E27B6A07AA62D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYJ6</accession>
    <name>A0ABY7FYJ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SACS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46919:SF2">
        <property type="entry name" value="SACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46919">
        <property type="entry name" value="ZINC FINGER, C3HC4 TYPE (RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81593">
        <property type="entry name" value="Nucleotidyltransferase substrate binding subunit/domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="1">
        <location>
            <begin position="2"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Sacsin/Nov" evidence="1">
        <location>
            <begin position="781"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="Sacsin/Nov" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1752"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1752" mass="201475" checksum="6C5229AE2E6CA637" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1A3</accession>
    <name>A0ABY7G1A3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF3">
        <property type="entry name" value="P CELL-TYPE AGGLUTINATION PROTEIN MAP4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20386" checksum="818C33FEA85409C0" modified="2025-10-08" version="1">MAVADGLVNHALATSSTKTYNRALASYKSFLAKHTTDLPQTYPSPLRAILAFIAHCYINKLTASTTLTLLQAMYLLAFHAFLRVGELTGHGRGPAVVTYSCITFHYTADIPSALELHLENYNHSHGKTFKLLIPAKVSPVTTCPVAALWQFCKLRGSNPGPLFTFPDGSQVLELWAPSLQPHSLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2E1</accession>
    <name>A0ABY7G2E1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_012875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR27171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045465693" description="Chitin-binding type-2 domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="103"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="233"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR27171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="296" mass="32782" checksum="102C22F2497BEA7A" modified="2025-10-08" version="1" fragment="single">MIGYTTALFALVAATLVIAGKDELVKCTPGVDEIIGKADCTGYYLCVFGKAMDMTPCPPGYVFSSSSKVCVPKGSIKDDCKKTTEGSGGYMTVLSEKGHLSPEERCSIDSDDVFPHPTECQAFYNCSVYNKPSMYQIFEQHLDECPYPQLFNTETKQCDHFENVNTNATSKGDGINVDPVRLWTPYYAVCYKERFDKKDQCQVDEDGRTQFFHPERNKCVPLDMIPREHGGLMPECGTKVNGGFLDVFGRCDRYAYCQGGKYIGTIKCDVGEVFDELKGGCVPERNACGVCSTHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2J9</accession>
    <name>A0ABY7G2J9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_013453</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">Golgi stack membrane</location>
            <topology evidence="12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="116"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="228"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR27749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="428" mass="49601" checksum="B9E041B7E4BB3C2B" modified="2025-10-08" version="1">MAVRCSKVKRQFILLIGLFLVLTVILQIVPSYYDAQKNTLTAMKFPQFGSRLLSNKSFTVVKRLKDPVSLWKFHPSDDRILLQAKFNPKIDLSLSPKRILLEQGLAGWNVNGGKQAFVEHDCPVKHCELHGHPNGEVFDARIFKEIELNSQLLGGAQAEVPRHSDQVWIMFALESPEASPSYEGLNDVINWTATYRYDSTMVTPYDKYQVYDNFTQISDYKSDKNYAEGKTKLAAIFVSNCFASNARLEYAKEVQQYMDLDFYGSCGNLRCDKGEGNNCFENLQKEYKFYLSFENANCRDYITEKLFLNALRHDVVPVVMGAHPDDYKRVAPPGSFIHVEEFPHAQALAGYLKRLNEQDDEYNDYFRWKSTGQFVDTKYWCRICSLLWDTNLPHQSIHDLEQWWRVENICIGKRRWDEISNSSSLHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2P6</accession>
    <name>A0ABY7G2P6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S19A3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_014417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002666">
        <property type="entry name" value="Folate_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00806">
        <property type="entry name" value="rfc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686">
        <property type="entry name" value="FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686:SF18">
        <property type="entry name" value="IP11787P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01770">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028739">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR28713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="407" mass="45938" checksum="8A20F1059D95D083" modified="2025-10-08" version="1" fragment="single">MLPWKLLTALVCAFGFFKDLRPSEAYLTVDNEIYPWWTYSYLLWMVPVFLLTDYFRYKPTLVGVGIAYIVTWALLLWAQGVPAMKAMQMTFGLGTACEISYFSYIFAVVPGDYFQKVSSFTRAASLAGKFIAYLWGQLLTYYNVLNYFQLNIFSFVSVCIAFLISLLLPRSEYSELFNPKRFVDEEEEKTNNPQAPSTDQTKDDSGDIEPCSGLNVTEKTISLLKFLFLEAKSAYSNKTVQIWSIWWALAACGNFQVANYVQNLWDILSPYHNYNPRKHHIYNGAVEAAGTLLSSCAVLAVGFLPVNWSVPGRCELVTTVICGLNAIFLLIMSQTSSIWVCYVLYDLFRSTYQIVLVIAAAQIASALTRKRYGFVFGCNTFVALLVESILTAIVVDKAGLDVKVRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2U2</accession>
    <name>A0ABY7G2U2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_014454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF5">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046998298" evidence="2">
        <location>
            <begin position="21"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR28750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="345" mass="37502" checksum="F18FF9C55AAC7631" modified="2025-10-08" version="1">MKISAIAVIALMGVLGAALADYGYGSDYGSSYGGGLGGAGYGYSYMPYYGGAGGAGGAGDGGILMLIGLLFVVVLLFSNNSFFNSTSGSTVTPITIVQDLQSTPAIHFHISICPIHYFKDDTNLAVLKALETETGYRSGKGQRTRSIVQIVKLEGENMERLLSSSQMSTPRLIAISKEEKIVNMAIVCDTILQSPGYSGHSRGHADNAGTTTAGGIQARFVCEWDVYREAMQDAMTLMYWLVEDESPNNIKFESLVATIKGLRLDILKMLCQGENAKYTSNDFINKTVVMFWNVILRNIIDDVKQSPLYSVMINKTTDIATHSQLVIYIHYLHPAKSRTVFCSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3B7</accession>
    <name>A0ABY7G3B7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="226" mass="24638" checksum="3D6FB97F4A5A0381" modified="2025-10-08" version="1">MLLVPALVTARFAARDIQDQTVPLIRSFYVDTALCYGSTSCLNSTSVQGLTDVAAKLATNFQSVKIRTSALPTMEDVLTRVLTSQGHISAAVEKATHLLRTDVDAMISTNVLWEHLSADKIVPTLLAHIRVPVGPGISWLLMGRHVTMNAGLLHHPVTNSVLTLPDLTTEIVEPDITSTLVHKLAKTLTNVQKGRLSALRHVQTHPAVIRAPVRMDICLERIHSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3I7</accession>
    <name>A0ABY7G3I7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ASO-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_011560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd13858">
        <property type="entry name" value="CuRO_1_tcLCC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13905">
        <property type="entry name" value="CuRO_3_tcLLC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="121"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="240"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="507"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR25856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="708" mass="79134" checksum="EE5154BBF863376D" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G611</accession>
    <name>A0ABY7G611_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CUL4A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_014478</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1030.10">
        <property type="entry name" value="Ring Box Chain A, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="5">
        <location>
            <begin position="263"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR28774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="558" mass="65256" checksum="88AFE7292D81ADFB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G839</accession>
    <name>A0ABY7G839_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="109" mass="11550" checksum="D9DF477EB393BBC4" modified="2025-10-08" version="1">MGDNVYGSCTAMGDNVYGSCTAMGDNVYGSCTAMGDNLYGYGRVCDSCKAVGDNMCDSCTPMGDNVCDSCTAMGDNVCAVVRLWEIMYATAIRLWVIMCATAGRITGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8H2</accession>
    <name>A0ABY7G8H2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PSB4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="87" mass="9891" checksum="B23C1C0070D43141" modified="2025-10-08" version="1" fragment="single">MARFRDLIEEECLNDGFGYTPSSLFSWLTRVMYNRRSNINPLWNTYVVAGWDNDGIYACSRFLGYVDKIGVAYQAPTIATGYGAYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G900</accession>
    <name>A0ABY7G900_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="140" mass="15714" checksum="DF09995660F5067C" modified="2025-10-08" version="1">MSQQLRAAALLRQAAELLDSQPPTTTSTTSSSTSSSSINSTVAATARGLFGPYRNTRPFQRERGRADRVEPAVSYWTHKFSVVPRYTQETVPNREEKFKLHSAGLGEKKLTFVKNSNKIDFERTFEEAYPKLRIVEGTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAK3</accession>
    <name>A0ABY7GAK3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MAR_033697</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">MELC-2E11</strain>
            <tissue evidence="20">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051503">
        <property type="entry name" value="ComplSys_Reg/VirEntry_Med"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45785">
        <property type="entry name" value="COMPLEMENT FACTOR H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45785:SF2">
        <property type="entry name" value="COMPLEMENT FACTOR H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 18" id="KW-0768">Sushi</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Sushi" evidence="19">
        <location>
            <begin position="808"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="WAR31155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1023" mass="115379" checksum="8994B7689520F18E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GEA2</accession>
    <name>A0ABY7GEA2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_034003</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="93"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR31461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="284" mass="32865" checksum="5BC4CED7DA85D8E5" modified="2025-10-08" version="1">MSSFKRLLPKNGTDLAATVFTLFGINVIFWFEMLYVRNDIVEAYPDYPIGRLYFHLFCGWYIYLNALSAMWKTIVTDSSTRGMILPTYTRPGWRFCPYCECNAPPRSYHCYTCKACVVRRDHHCVFTGNCIGHRNHRYYMTLVFFCWLAALYASIMNVNIVIRVFAETGPLAIVKIIFPFLVWVFGYIDFGEMLLSAMLLFCMAVTMMVSALLFYHARNMMCGQITTERTHHITKYDLGWPRNVQAVMGKNWSVAWLSPWIPSPLPGDGCDFPVVGEYENPKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GFF0</accession>
    <name>A0ABY7GFF0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="108" mass="12737" checksum="066A05B4B834BED5" modified="2025-10-08" version="1">MHDTVNVHVHDNNNQITKYVREEQTKQIPSGFKSRRGVGWHGELSDNKAVIKTHVVYFMNNCEIDAEVLIKNIWNFICHYQDSHDQCLSTSRCKTDPKYERSKYIIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GFZ5</accession>
    <name>A0ABY7GFZ5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43907:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43907">
        <property type="entry name" value="SLEI FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="580" mass="64788" checksum="0382BAA79D734530" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D8X4</accession>
    <name>A0ABY7D8X4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006565</name>
        <name evidence="3" type="ORF">MAR_006571</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ94100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="89" mass="10271" checksum="45D69EFBCDEDC169" modified="2025-10-08" version="1" fragment="single">MFLEQHVTGKVLLNLSIDHLHNLGITSLGHRYELSTEIELLKAHNFRLLNFPPLSQQPTKTLEKHEPEFKTAEVTLIFGHHLRHGKSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D963</accession>
    <name>A0ABY7D963_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="256"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ93909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="933" mass="107303" checksum="2273EE915494D055" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D9M0</accession>
    <name>A0ABY7D9M0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_006822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045465646" evidence="2">
        <location>
            <begin position="22"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ94351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="267" mass="30435" checksum="048F3DB566A99F1C" modified="2025-10-08" version="1">MAFSILKALTLLVVVSQAVFCQENSETNVQDNSTLHTNATTANRSTSENAATTENAPTTPAITTSTSTESHGNWNADLESRLERSRNAHLQFLRQHVLSSLGWTTPPNITAEEKRQILMGIGYRTPVFVTRQKFCYFPALNHRNMRLIDARMVTWDSARWVNLEVTEAVKRVMSRGRRNGGFEVHVRDMEENVLDAKTVIDPTVCSFTTEYDCTDDTESQYEEEPTEVNYSPVLEIRDHLSPRWGRIIRSQILDNLFVTQRCSFPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D9U5</accession>
    <name>A0ABY7D9U5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ93495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="87" mass="9972" checksum="CDB5A4FB2771C59D" modified="2025-10-08" version="1">MIDWTQRNQLKHDLITLQEELAQPPEIPVISFHPSQNDFSNDHVTGLETKSVDDLIDVPYSPTAIYNPNTPWVEQSAYENPLRSPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAP7</accession>
    <name>A0ABY7DAP7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CRUM1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_007203</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043555">
        <property type="entry name" value="SRPX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46343">
        <property type="entry name" value="HYR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46343:SF2">
        <property type="entry name" value="SUSHI_VON WILLEBRAND FACTOR TYPE A_EGF_PENTRAXIN DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045386799" evidence="5">
        <location>
            <begin position="19"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="71"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="155"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="242"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="372"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="409"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ94732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="605" mass="67614" checksum="6AB7408EE2A51E14" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBB9</accession>
    <name>A0ABY7DBB9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="24" mass="2834" checksum="81C9AE9333FD8F73" modified="2025-10-08" version="1">MFCLENQMITVKCMRVNVQTNLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDH2</accession>
    <name>A0ABY7DDH2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GBP4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1000.10">
        <property type="entry name" value="Guanylate-binding protein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003191">
        <property type="entry name" value="Guanylate-bd/ATL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02841">
        <property type="entry name" value="GBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate-binding protein/Atlastin C-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="188" mass="22115" checksum="B368F303E01CE9F6" modified="2025-10-08" version="1">MNSVKENMPPCLTDATTLMAAEENRFAVRKASECYQEEMKKRINKHMPNDKGLEMYHNDCMDVAVNKLRELVVLDDGDIFHRKAAQCFENHLKRFKSIVERDSLDRCRKSLDQLDKKIQRKIRENKYAHSHGYSEYIADINTLTDEFKKQERYLGSITRAALQEYMDAKVEEEQLVYEMVKDKIGTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGM1</accession>
    <name>A0ABY7DGM1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="266" mass="28966" checksum="518606EE87E46683" modified="2025-10-08" version="1" fragment="single">SGGKVRLSRLSVVAESGCQWWQSQVVQVVCGGKVRLSKLSVVAKSGCSGCLWWQSQVVQVVSGCKVRLSVVAESDCPGCLWWQSQVVQVVCGGKVRLSVVAKSGCPGCLWWGVRLSRLSVVGCQIVQVVCGGRVSGCPSCQWWQSQVVQSQVVQVVCGGKVRLSRLSVVAESGCPVCLWWQSQIFQVVYGGRVIVVEVVYGGRVRLSRLSMWWQSQVVQVVCGGRVRLSRLCMVAESGCLWWGVRLSRLSVVAKSGCPGCLWWQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGN7</accession>
    <name>A0ABY7DGN7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ENASE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032979">
        <property type="entry name" value="ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="TIM_ENGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246:SF1">
        <property type="entry name" value="CYTOSOLIC ENDO-BETA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246">
        <property type="entry name" value="ENDO BETA N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosolic endo-beta-N-acetylglucosaminidase TIM barrel" evidence="1">
        <location>
            <begin position="66"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="430" mass="48073" checksum="1F939A7E1925D165" modified="2025-10-08" version="1">MDRRNPVCKPLFDLDEVLSWQPAQDEFCVSSVARRPRKEQDGPRMLVCHDMRGGYLEDRSRIWNPISTEWDDGKARCKIFLETEESYKAFADQLVKIAKYYGFDGWLINIENVIEPVGNPWWNITVQDLQPCFCQTHSDNQSAENQSSTGTQSILPGSQPFMSGAGTQSAMLGTKPGLPGAGNGAQLIGNPIPTIGTGKSFLGGSQEFCGNALQQMDVCTDDCFTGGSCLRLTADVVNTKFVEYNLFETAVELKQYTSVYVSITYKILQDPDCDVFLELHLRHDEQSIVLVLLPFPDGDKPVPKFGKDTACMYVHALKQTDLPNLLSVSSPTQNNTRWKTRWFPVYSLYLKFCQLTKVKVGLTTTDPQPKKCIALLGELKIIPVDSLPEKFPQAGFVSVIPDSSPAHPLIEPGKNDFNNTLQYVRLPIWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJU2</accession>
    <name>A0ABY7DJU2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_029444</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ96754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="150" mass="17021" checksum="CF79A591953B0F37" modified="2025-10-08" version="1">MSKLLDGTTDNSTCQKTISEGTATLRTRKFMTNRLLCRRQMIVDVLHPGKATLAKTEVREKLARMYKTTPDVIFCFGFHTQFGGGKTTGFALIYDSLDFAKKFEPKHRLSRHGLYEKVARPGRKQRKEKKNRTLKVRGTAKAKIGAGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DK81</accession>
    <name>A0ABY7DK81_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_029787</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Golgi apparatus</location>
            <location evidence="11">Golgi stack membrane</location>
            <topology evidence="11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF194">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="72"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="201"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAQ97097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="361" mass="42126" checksum="C2BA1B463B2DF4B6" modified="2025-10-08" version="1" fragment="single">MAHSRNRAVKEELRFNPFRMFLFLCLTGAITMMLVGYTMLKGEKYEENDAGMPAFVESHADDSQALKEVISEPIILWWTPFTGEKGAYRRCGQVSCFFTVDRHYWQHQKTKAVVFYGTDLRVHDLPMPRKPEHEWALLHEESPKNNLVLHMPAFIPFLVDPIAGMEHTEFYHLMARYKFTLAMENAICDDYVTEKDILPDDHSAIIIDDFKSPKELANYLNFLDRNDQEYNKYLSWKKTGVTNPLLKEMLSNRSWSIVETWKYGRTNFIEDFECLVCNRLHSNIKLANQGKPEKVFIADESHLVCPRPEEFSSGYNSWLDDWNQNVILAEAARYFADKNLPITKGDLHAKQSEISYQKKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKN7</accession>
    <name>A0ABY7DKN7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="399" mass="43639" checksum="6DE56DD27137572E" modified="2025-10-08" version="1">MTKEHVDVMAIHIDVQQPKKRGRKPKRQRGRRPGEAGDKARKAQDALHVTSFSLGRLQDKPEKDADDGSEGKDNRPEVDAPSSPADTRTDEERRLDEFVKTLRLTKTTALTKVPDVPKLDSADVSNITKRDVSSDHGDVDPEMPVLQKEGLAGDSFVKTHPDISVSVDALNATVTPPPTPPSERVGIEQNINAIDGGKLVETFKSTLASPSVGLKLKINREKVKLDMPITDNEVKPADKEQSKLDSAVTQNVEIKTPVSAPKQNLQSMMLQDALLSARKYKEQLLQNRQTSPVKTPNTASPKPLTTYPDSLKSKPVTMPTPSSTSVKLEPTTESQNGLNSATVINGRVAGVKQERAAKMEPSVAFPSLQYGQMPSMDDMRRLSAMPFKDFMSVMASVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DM81</accession>
    <name>A0ABY7DM81_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PCR3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cornifelin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="109" mass="11788" checksum="B79236129C4A607F" modified="2025-10-08" version="1" fragment="single">SSEWAHGLCSCFDDLGLCIIAYLAPCVLFGQSAEKMGEGRCVVCGLVYFIPILNLIEAVIVRGKIREQSGIDGTTCHDCLTIAFCPLCALVQEAMEIQNTPAIMSMARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMR9</accession>
    <name>A0ABY7DMR9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="954" mass="107342" checksum="B038D9684908A038" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQU3</accession>
    <name>A0ABY7DQU3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="156" mass="18079" checksum="0A05B7FBC666E9DD" modified="2025-10-08" version="1" fragment="single">VYRHRLSNQSSYHVHSASKNSCRGENVDYISYSCTIYLNCLMSSLGFGLRLDPVKFCVLVFPRDYLITYTAFKYTESILCYFIPLVVQIVCYNITGKQLFIDIKELHLQNLRQSPGNNGCYQDADCQRRAVFCQLFSTSNFVILQHIFTTTRHGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DR90</accession>
    <name>A0ABY7DR90_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DPGN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053265">
        <property type="entry name" value="Serpin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21131:SF0">
        <property type="entry name" value="GEO10195P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21131">
        <property type="entry name" value="SERINE-TYPE ENDOPEPTIDASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00282">
        <property type="entry name" value="KAZAL_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kazal-like" evidence="1">
        <location>
            <begin position="64"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="1">
        <location>
            <begin position="104"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="1">
        <location>
            <begin position="153"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="1">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="1">
        <location>
            <begin position="224"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="1">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="1">
        <location>
            <begin position="304"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="1">
        <location>
            <begin position="353"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="405" mass="43040" checksum="1A34BDF1367803EB" modified="2025-10-08" version="1">MFGVLTAIPAGLNGKYKLSVYIRHIPQAMTDSFWLTIQADGENERTLHYHCTVSSCSSDFGISKQSNGQCPTQCICTLDYTPVCGNDDVTYGNDCQRQCKGVAKKHDGECVPACACPFNYDPVCGNDGVTYPNSCAMECAGISKQSNGKCPTPCICTLDYTPVCGNDDVTYGNDCQRQCKGVAKKHDGECAPGCACPFNYDPVCGNDGVTYPNCCAMECAGVSKQSNGQCPTPCICTLDYTPVCGSDDVTYGNDCQRQCKGVAKKHDGECVPACACPFNYDPVCGNDGVTYPNSCAMECAGVSKQANGQCPTPCICTLDYTPVCGNDDVTYGNDCQRQCKDVAKKHDGECAPGCACPFNYDPVCGNDDVTYPNSCAMECAGVAQKHVGDCAPGWMKGWTAETGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRW9</accession>
    <name>A0ABY7DRW9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9324" checksum="D22F77A726FACDEC" modified="2025-10-08" version="1">MRWKTPETLGCHEGWGSEKRLSGKIFISVDLISSWCRGGEAFNETGMRHFGFRTKTKQRTDFSGYYTLIKQSDCSNTTHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DS26</accession>
    <name>A0ABY7DS26_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_023266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ98893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="694" mass="77951" checksum="DD78D802DB4CAE2D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DT23</accession>
    <name>A0ABY7DT23_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S22A8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_024129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ99756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="194" mass="21506" checksum="7C65B2DA686B0AD1" modified="2025-10-08" version="1">MLISSSLAGNRFLNFFLGSVVEYPAAFMEYVMLNRYGRKPTVIIFHVICGVALIIATIINTCADGNSAMVLTATVFTLIGKFAITGSFSTIFLYTPELYPTNMRNAGIGMSSAAARVGGMLAPFSRNLAEFIVWGPGLVFGVMCAIVSVSMLWVPETNQHELPQTLEECEQWYKDNRLRLPCSQDRRRSERNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVD3</accession>
    <name>A0ABY7DVD3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Expansin-like EG45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_025023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd22271">
        <property type="entry name" value="DPBB_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49590">
        <property type="entry name" value="PHL pollen allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046172747" description="Expansin-like EG45 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR00651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="27588" checksum="5FA46E2799534D3A" modified="2025-10-08" version="1">MYLCIATLLYLAVAISALHDNDILNLYKHTFQGDGTYYGAKTSGLCSLDVPHLPPVARHVDKLVALNGQQMFGSSACGMCLQVTGSGQGAGNDPITGTFTAYVKDLCPECLAVSFCGMSAAGSVDLAEDGDGRWGVSIRAVQCPSSGPIEYALQGSNDWYIKLQVRNEIIPATTVEMFQPKSGIWVPLARTADGFWTFPASGGVDKPIQRPIQLRLTSPTGQTVTDHINPSIYRDYSWPGQSPIFLRSITSESFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVG7</accession>
    <name>A0ABY7DVG7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_008256</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd10229">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047273388" evidence="4">
        <location>
            <begin position="23"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR01698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="745" mass="84956" checksum="FDD521D7A64FA766" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWU6</accession>
    <name>A0ABY7DWU6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF26">
        <property type="entry name" value="TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="46883" checksum="E255A48BB4261B76" modified="2025-10-08" version="1" fragment="single">MLKPQCNVELPKDCRTLLQTPGVVEYSEKCGGKYIYFGIETVEDKTIKLNFNIDGIPVFKSTVTQFWPILCSLGDYTPIMVSIIYGPSKPSSLEDFLADFLTELDRLVLEGISFENERVNVNVNAFICDAPAQAFLKCIKGHTGYNSCERCIVRGYYKDNRVILYSEEFFTARTDDEFKAWRYPAHQSRITPLAASDIPCVCGFCLDYMHMVCLGVVKHRILLNVFISSPLYKSLKYQIISFLFPVNYHPSLHVNLDHCTRLSVGKLLNLDSFFYILAQFVVYNVHLLIHLSDDFRNFGCSLNDISGFPFENHLQSIKSEECQKSNCSDGAYAFVKKERQQKNICQEQPENYFTQPCDSKLLNVVLVKPRQRMKRRNVDVSELYRKLVRLPVEHGYVLIPMLHTMDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYY5</accession>
    <name>A0ABY7DYY5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">JMJD7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_009505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF83">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046683297" evidence="1">
        <location>
            <begin position="29"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="394"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR02947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="583" mass="67054" checksum="0B5ACE1488F6E69A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZV7</accession>
    <name>A0ABY7DZV7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="120" mass="14063" checksum="78056BE95A1EB0AB" modified="2025-10-08" version="1">MSRRRLSSRCDISRRRLYSRCKISRRRRLSSRCDMSRRRLSSGCNISRRRRLSSRCDMSRRRLSSGCNISRRRRLSSRCDISRCRLSSPAVIIVVVAFLAAVILVVVVFLTTVIFFVDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2A0</accession>
    <name>A0ABY7E2A0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BCL3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_019516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="396"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="465"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="499"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR04147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="578" mass="63999" checksum="C08199A35736FD9F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2X9</accession>
    <name>A0ABY7E2X9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046683302" evidence="1">
        <location>
            <begin position="20"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="224" mass="22215" checksum="BE9790D39B891B5B" modified="2025-10-08" version="1" fragment="single">MKYLLLLAVALFAVSSVSARGKWSRPCKGKWCGGYGGGYGGGGYGGGGYGMSGGYGGGFGGYGGGMSGGYMGGYGGFTGGKKFGGYGGYGGGGYGGMSGGYGGGFGGYGGMSGGFGGYGGMSGGFGGMSGGYGGGYGGFGGGMGGGYGGGYGGFGGRGRYCKCAPRCNKWQKFVGRCPWCKKGCKLVFCCNRDTDTLRRISPDESIVHCSFCVYILNKASLNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4L3</accession>
    <name>A0ABY7E4L3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HXA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_020324</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664:SF2">
        <property type="entry name" value="HOMEOTIC PROTEIN PROBOSCIPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664">
        <property type="entry name" value="PROTEIN ZERKNUELLT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="74"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="76"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR04955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="614" mass="66453" checksum="CE0135F329D485D1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4T2</accession>
    <name>A0ABY7E4T2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_020377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd03156">
        <property type="entry name" value="uroplakin_I_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF544">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR05008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="241" mass="25930" checksum="A97AD36094C407C4" modified="2025-10-08" version="1">MSTDAEHYVVFFWSGEVVACPDKYCVNVQDIDIGQVMINISIGLILGGLVLLGLSFLGCCGACCRFEFILYVYAVIIGVCLIGESVGVGLLYGKPSLVKDEARSSLSIYKGLASDDVYSLAWNIVMIQFQCCGVDSYRDFNVSKSWNRNPVPNDASLTLETPVACCKTLPSGTSQSEFQCALQYSSATSNGDQGCFDSIWKESLGNTAIAVPVLVVLAVIQILFIISAVSVARAEDRVSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5N8</accession>
    <name>A0ABY7E5N8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_020529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46270">
        <property type="entry name" value="ARMADILLO-TYPE FOLD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46270:SF2">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="476"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR05160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="700" mass="79878" checksum="7C9EEE89CA9AF1F2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6X7</accession>
    <name>A0ABY7E6X7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CPXM1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_019690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="180"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="270"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="4">
        <location>
            <begin position="390"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR04321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="449" mass="48526" checksum="A40C85F6A707E887" modified="2025-10-08" version="1">MHEDPCPGVSKYLQIDYQCVVTLGQPVQMTTTRKQPVTTPNIPVTTATRATPPTTTAAPPQTRAATTQPNLPPGIIPINVGGGGGGNSAGFGVGNSVSKNQTGVTQCHEFLVSGPRGVPDGQLSSSSRLAIANNAHRGRLYTDVDVQRGLEGAWTADPADSNPWIQGRHVNPSTGCCAEWTTGYKVLYSDDGHTWNTVKDANGQDQVFVGNTDTDTPITHIFPCPIVARYIRLQVVSHVGRPSLRLELIGCPTNSPDLGTCPPGWKERPGSATCYFISDQSDTKTWENAMINCRRQQGQMVKIDSAAEKQWLIGELAKLQTTQKLTNFWTGLNNRPRRDNNYYHWHDGTSLNANVVNWRSGEPNNGGGIEHCAEYLTTTDRLNDPGCLKTSDCQALPGITYGDYPSCTGCGFFMTCAPSGAYDRNCPLNLKYDANKDACSRTSSNCAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7J1</accession>
    <name>A0ABY7E7J1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PLMN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_021346</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00108">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00018">
        <property type="entry name" value="KRINGLE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0420">Kringle</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1171"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="8">
        <location>
            <begin position="128"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="8">
        <location>
            <begin position="294"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="479"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="9">
        <location>
            <begin position="598"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="8">
        <location>
            <begin position="988"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="642"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR05977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1228" mass="138140" checksum="0408EE6E3EBFB2A7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E883</accession>
    <name>A0ABY7E883_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF25">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="431" mass="50041" checksum="F7C333D8B02146DD" modified="2025-10-08" version="1">MNVQRLIIAHQQIDEKFSQERNTCLLSDETSKFGRKYQGFHAADEEGNTWCLGVREMSTESVKHSDIVIGQIGEVWESFSEIQKSQLTKLYIFFAPCMYWSTYPSLLPQHCCNTKRQCSMNTLQYMTRAFRKHPTGGDEKSGVHGSFSAYLHDFLNQHKLQSVPLERFRGNRFNILFSSAACVYFLAEEMKEFLEISADNRFLQAVKSDLNTMEYLARCKALRFVFELITKPLWAQIERTDTNIKDIGVVYREVVDYLENLDLHSYLKGTSVMSFVDKDKVTSSIFMKNLLTESPYDDKILIILEIMIPALCGVTKRLFKDHLEVKIWENPGDEIRDKTVATPNNNKFSETVFGVLDRILREQPNVSMIAAESYLVFCHKKTLKWIESKTEKQKEELLSAAHKDVKKMRKNFLKRKNQIEKERKAILNAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9G5</accession>
    <name>A0ABY7E9G5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="120" mass="13680" checksum="81CBD61510E64503" modified="2025-10-08" version="1">MLVITYNNSIDEVTSEDDFDKIEVLSSQVEIVDEFFLVPIANLKEMEVEMLDRKECERKRIARAVALVSAILFLVSVALVTVSLYMAKDIDAMVRYSNEMLKNITTGWPRRLVTSSLMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9M5</accession>
    <name>A0ABY7E9M5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="26"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="228" mass="25918" checksum="4C812CFCDECDE9DA" modified="2025-10-08" version="1">MCDLIDKSENDSEVTDFKKPSIVEKVVLGGDVLTNERAYSAQQAMANGNTDFECLGGFIHRPEGFHRLMNFVQVIYQMFYQQSADRGTLWCLRIVVNQRDVSGPKEVVQNYRHHDSLFLFMALLLKSASEAYKYHGDGARAVRNLKFEGVFAGAIGHTKYRLCLWRTLAYVKCVLSPRKAYEYMWNISCNIVGGLGNNIPNDNLVELMVKTIKKKFKTQGANVRTDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9P9</accession>
    <name>A0ABY7E9P9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PRKN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_016715</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd20340">
        <property type="entry name" value="BRcat_RBR_parkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16627">
        <property type="entry name" value="RING-HC_RBR_parkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21382">
        <property type="entry name" value="RING0_parkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047534">
        <property type="entry name" value="BRcat_RBR_parkin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003977">
        <property type="entry name" value="Parkin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041565">
        <property type="entry name" value="Parkin_Znf-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047535">
        <property type="entry name" value="RING-HC_RBR_parkin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012496">
        <property type="entry name" value="TMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041170">
        <property type="entry name" value="Znf-RING_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF40">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07810">
        <property type="entry name" value="TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17976">
        <property type="entry name" value="zf-RING_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17978">
        <property type="entry name" value="zf-RING_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01475">
        <property type="entry name" value="PARKIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="572"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="708"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="768"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="807"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="864"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="Parkin RING/Ubox like zinc-binding" evidence="9">
        <location>
            <begin position="121"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="RING/Ubox-like zinc-binding" evidence="10">
        <location>
            <begin position="201"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="TMC" evidence="8">
        <location>
            <begin position="696"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="927"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="930"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="953"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR06757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="967" mass="108049" checksum="B8B14A048369444A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAU1</accession>
    <name>A0ABY7EAU1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF1">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="341" mass="38327" checksum="51786888C20FE3DB" modified="2025-10-08" version="1">MDPSSEPFSNKHMKRRLIEYFGERIFISESCGKSNVVTLRSEASKLIENCYKQSTRDNDETKKTKIIQTAAKLIKNDISEIESNQDIYPGSEEIENVDKCLSYLPESLRILLDILITGKDTDLKKSCNWPSYNTVYKSNIFTGAISVLLSSCICCLSHDCLCLIKIIVKDPIYSIPTNFAPLPESIVADMSYNIDMLWKMSWLFRPKTPQWNGVMQMVHAGSHPAVSTTMLLPMIDMDPSNESCIYSTLSFVTDLASAYNVDPIITFDQPLWYKAQMIIDTQSQSSPMSHIVCRLGGLHIQMSFLGTIGKIMTDSGLKELLETVYAENVVPHMLSGKASNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EB00</accession>
    <name>A0ABY7EB00_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="101" mass="11837" checksum="B07EC9500720F3A6" modified="2025-10-08" version="1">MRSLDKRFSLTEAEGRFQKACDQIVLLNHRLGEVQKRYKMAKRSNNKAFRYNLRLKLAVIEGVRNMYYDFAYSKADALLSFDVSFSTNPSKSSPDLIRIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EB21</accession>
    <name>A0ABY7EB21_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="600" mass="67807" checksum="19F513373B741383" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBU0</accession>
    <name>A0ABY7EBU0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_021253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR05884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="27384" checksum="7AC8D1BC56948369" modified="2025-10-08" version="1" fragment="single">FSVDNSTAVLNPQEPTANTDGNVSITTPCIFPTSSDSITINWYKIFVNKANQAELLDASNADIQSYSETDTTGCSICGTKSAGKMIVGVTYKAPSSNGDEIKLQVEIIHADFTDHLYYTFDQSYYLPGTPTTTTTTTTTTTIPSTTTTEISTTSTTPSTTTTTPTSTSTESTTKTTRMPSTATNAPTSTTTETITPSVTNNPSNERTVIIVVASTVGGVVLVGLVVFLGLFLYRAKRHGHGKGKHGHKRTTRQQRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECU8</accession>
    <name>A0ABY7ECU8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="134" mass="15270" checksum="316F752D3B0BB0AD" modified="2025-10-08" version="1">MVDSTHLFLDGRVFAISGSMFLRVRRLSIDRRFLGTIAFMSGSIISAKMSLGLAPFLTVDQNLLIPRTMTLYDLKESLPQTSPDELNELLRAISSPTDKKHQKAYEEPYVYKKIVDRMYQSVAKVTSHLTELKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ED00</accession>
    <name>A0ABY7ED00_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LFG2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_021955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF127">
        <property type="entry name" value="PROTEIN LIFEGUARD 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR06586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="229" mass="24897" checksum="6D1C12FA85270BA9" modified="2025-10-08" version="1">MYTTADRQQVGLRTQVPTESGAYPDDPAYPPPPPPMPSGYAPPQHATFGVVDTQPRPRKDNDSSKSSNSTIFGGSFDDDAVRRGFIKRTIAFTYLVATLSSFFDTNSVIVAAGITAMLCLAITLFAIQTKIDFTLCTSLFFCILIVLIYFAFVSIILSFVVPDGRFIDGVYGTLAAMLISLVLVYDTQRIIGGKSEELNPEEYVYGALQLYIDVVVLFLIILAGCGKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDC3</accession>
    <name>A0ABY7EDC3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CP4F6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_017966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF201">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 4, SUBFAMILY B, POLYPEPTIDE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="384" mass="43635" checksum="A93B874346576013" modified="2025-10-08" version="1" fragment="single">SSKDYAKYGMEMYKTGCKLFCVWLGPYPVLCVNHPDTFKQLIGEGLLISDGRKWERSRKLLTPAFHFSILTGYVDIMNKVSNDFQEKVIENMSASTSVDIYPLVSRTTLDAMMKCSLSFDGSMQAKENEEYVKAVQRMERAPVGGWSFEREEATGLLGHSAKDEQGRGLDRQEIQDEVDTFTFEGHDTTASALAWGLYALGQYPDIQEKVYEDAKSVLGSKEHVDSGDLHAFKYIPMYIKEVLRYYTPVPVISRKSPNTIVLDGLEIPPGSRVDVHIYVMHHNPAIWKNPEEFRPERFSDKQKEEHDVFGFVPFSAGSRNCIGQVFALNELKISLAKFVNRFEVRPDPGHKPDMLWDMITRSTTGLKVCLKERSNITSDTNART</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EG79</accession>
    <name>A0ABY7EG79_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CYSP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_018986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.170">
        <property type="entry name" value="Cysteine proteinases. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047076733" evidence="2">
        <location>
            <begin position="18"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="4">
        <location>
            <begin position="45"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="127"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR09028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="330" mass="37129" checksum="264318709DE5098D" modified="2025-10-08" version="1">MFVIYVVLTLALVEVNGYGVREMSMVDVRFAEINQELSEPIDSLFENFKHEYGKQYANASEESQRRTIFAGNVEYVNAHNDLYLSGKTSYYMGVNQFSDMTYEEWKSIFTSQQIDDATTRNDSIYLTPDNFEAPPSVNWGSCGSCWAFSATGAIEGQHFRKYHRLVSLSEQQLLDCSGYGCQGGWPNKAMFYVRSAGGIEAKQAYPYRAQSGPCLFNKSMAVAHVHGVLRVMGNERDLMDAVASKGPISVCIAVNEKFRHYRGGIFYDTSCSTARDGHAALVVGYGSKPREYWLVKNSWGTRWGEHGYIRMARNKGNMCRIASDAVFPTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EI09</accession>
    <name>A0ABY7EI09_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FGL2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF394">
        <property type="entry name" value="ANGIOPOIETIN-RELATED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="130"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="332" mass="36721" checksum="5363940A78DEF3E2" modified="2025-10-08" version="1" fragment="single">DVGTLTKRVSYLESLVITLENKVEELIGRTTDVNGIINEQRSTIEDGIMVIIRGPPGVTGLHGLTVLIHVKEAEEVDTVDGQWASWSTWSTCSGSCGDGVETRNRSCSDPTPANGGKVCPGPDIETNPCNLQQCVKYDCSDVLKLGLSRGSGDYRITSWNTDKEVDVYCDMDTDGGGWTYEQGFGSLDGEFWMGLDLLHSITSRANMTLRIDVSLTEGTTGFDEYSGFYISPPDQYNFNVDRRINSARMSDSFLLSTIGDALDINHRPFTTYDRDVDKLPGNCAGYYGGGWWYSRCAHSNLNAQYNSGGFQYYSFKQSTMLKTSTMMLRLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EI52</accession>
    <name>A0ABY7EI52_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P52K-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="156"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="238" mass="27425" checksum="385498F9198C919C" modified="2025-10-08" version="1" fragment="single">PYESLFFQAERNDDEVWNSLFQKAVDIASDVDVIPARRYGRQQNRPNAPGNTSEFWKRNMYLPFVDHLLVELETRLMQDHGRSCAQKLLPSKNDGLPRESIDDVYQAFHACLDADETIFVRECERWRMWWTDATLAVDRPAASVSLAESITLASKALYPSIRHCLTLLMVMPASMAIAERSFSVMRRVKTFLRSTMGTERLSGLGLMNVYKDREISAERVVDKFANQQNRRLALVFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIL3</accession>
    <name>A0ABY7EIL3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DLISH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_018197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043539">
        <property type="entry name" value="Grb2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46037">
        <property type="entry name" value="PROTEIN ENHANCER OF SEVENLESS 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="232"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="841"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="374"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR08239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="907" mass="103041" checksum="88A14728A3CB3DFE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIN0</accession>
    <name>A0ABY7EIN0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046880419" evidence="1">
        <location>
            <begin position="24"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="196" mass="22183" checksum="1035FDEA6C614E2E" modified="2025-10-08" version="1">MSCWKFVFVVLACVLVAAPTAMSDPETVKVPKGLNIGDFDKYLYYCVPLINGSALYVPDFNFFARVDKIGDNEYSTNTKGDLINSENQPECIQRPDNLTQTTEDTAVFETSTGALQVFWTSDPTVYVWTLRCHEPQNTRHCHILDVDVGLLVKNVPHDLSWKDVLKDLTSKTRVEFDDGNFKCFFVYGESSLCDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJ87</accession>
    <name>A0ABY7EJ87_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="73" mass="8422" checksum="4F838D9ADFBAB564" modified="2025-10-08" version="1">MNETRPELKFKVVYARQLETYSIPPLIALEIIGTDCNIIETLLEIESNVIVDEDNKTTINRFNVKVVEEKLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EK67</accession>
    <name>A0ABY7EK67_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160:SF10">
        <property type="entry name" value="MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="52111" checksum="E14CDF88D025F329" modified="2025-10-08" version="1" fragment="single">MPVVTQLLLQEYVTATPFITDEAETCSFVCGSCVENIPERGSCINADDIIDEPPLLEISAPVEQLSSVDEEIFNEPPVLERSVPLSIYGAETMVDYLSESGQNQAGDFSLNISGLTSAETSVLHSTITELSDADAARVTFNLGTNFGMERETRESNESTSSIQSQTHQHQLSVNMSRVSISGVADQNWTFDVTRDEQLLDATVIFERSLDGSAITDTVLQDPMEVRFEVLENGTERGGKKFVSSDSFSYTQKSRMRVIGWTRQWRCSVRGKTPCTATVNKKEGIFKRGINDHNHASDGNIGKKLKVKAEINKEFIDESFLGDISHDGQRHLLFAARDQHGVLRRARRWYLDGTFKVRKEPFQQLFAVHAFVRSGVNKKQVPLVFVLMTRRRKEDYIAVLEKLLGSNRLPKSAFRRLQEKATTTKLEILCEYIDDQWMSNSCWTVREWSCYLQSVRTNNDCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELN8</accession>
    <name>A0ABY7ELN8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NECB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_018069</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF23">
        <property type="entry name" value="FURIN-LIKE PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045583549" evidence="9">
        <location>
            <begin position="21"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="10">
        <location>
            <begin position="456"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR08111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="605" mass="66950" checksum="28F3BBEE75B7015A" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EM64</accession>
    <name>A0ABY7EM64_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KMT5A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051760">
        <property type="entry name" value="KMT5A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46167">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46167:SF1">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="431" mass="47612" checksum="AFC87BD007849119" modified="2025-10-08" version="1">MRPTARLKPIDKALYFIKLDKDQDGYTVKDFGFKGRGIKTIADRKNGDFLLHYTGELITGEEGDRREAKNSTGFRFFFISKGKQLCVDASEESGRLGRLVNHVTAVEDQLTCTARVESPSFQANTPDASDTNTVHQTSSTDGDTLETNVEQSSPVTAVEDQLTCTARVETRVESPSFQDNTPDASNTNTVHQTSSTDGDTLETNVEQSSPVTAVEDQLTCTARVESPSFQDNTPDASDTNTVHQTSSTDGDTLETNVEQSSSVTAVEKQVTFPDIVESPSFQDNTPDASDTNTVHQISSTDVTAVEDQVTFPDIVESLFWEDNADPCTDDRVDSSSCDDGFETDDFPMLQQLKEDQVLGEDHTVVAKSAASVSVQRKRKDSHADMDSDDSLHDPTYTLEKGSEESSGEELKMRKRRWSEEENIIFKQWEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMT6</accession>
    <name>A0ABY7EMT6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">INT8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_025473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Integrator subunit 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038751">
        <property type="entry name" value="INTS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057980">
        <property type="entry name" value="TPR_INTS8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13350">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13350:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25756">
        <property type="entry name" value="TPR_INTS8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTS8 TPR repeats" evidence="7">
        <location>
            <begin position="312"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="INTS8 TPR repeats" evidence="7">
        <location>
            <begin position="496"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR11293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="692" mass="78472" checksum="B29F685592F64CD0" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMV5</accession>
    <name>A0ABY7EMV5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="153" mass="17524" checksum="77B431BE8BCD2F8F" modified="2025-10-08" version="1" fragment="single">MNDLYPPRQQEHRRSLVLSQEKITQIAFMTTGQRENSLWAAARKLRFIASNFGQIIAASKRNRLFASLKKRLLSAYNLQKRAPIQWGKMELEAFGFMNQASLGVRLMGSFNGIIVAAFTFNRMNSRYHRGVVPFLGQGHDCYGGMPFKQRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENB2</accession>
    <name>A0ABY7ENB2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF4">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="333" mass="39481" checksum="C01928ABD3E7AB6E" modified="2025-10-08" version="1">MIVDHYLILHMIGRDTLKMVGVLNIAKLSKRKHEDMSDSEQDDSVEDNEAYVQLWKKARKTNDNKYQKIYNTFIEHGEESDVAQELAEERIKPYNEKDNYILPLKNSRLHTQIMAQIDTLISKIHSTTSALTKALRKHKNSFQDLFDMEFTELKIVKRRNLMEFKARKVQELMKKEEIHYFPTQNETKASTSERAILTRRPDSCATYRTRTRAAFYRFYKRSLTIITTRINYRNETHRCHGHKSERSGISHIFCAKLGYYVRISHQKTVFTRAYHQTYSGEVFKVHKRYHRGTLPIYRLQDLQDEDIKGTFYQSELQKISIDPEQKGTVEKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESV9</accession>
    <name>A0ABY7ESV9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UN93A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_026437</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd17406">
        <property type="entry name" value="MFS_unc93A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF13">
        <property type="entry name" value="PROTEIN UNC-93 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR12257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="485" mass="53817" checksum="9705B5D3C6975326" modified="2025-10-08" version="1">MSEKSEKDELKNDISLFGGSGVSLTPISPEKGPMPTAPPPPMTRLRILKNLTVVSFGFLLLFTAFQSLSNLQSSLNKSEGLGVIGLSVIYGALVISCMFLPPFIIARLGCKWTIPLSMGCYVLYMCANLYAVWGTIIPSAIILGLGAAPLWSAKCTYLTQTGVWYAKLVGKSEDDIINRFFGFFFMLFQTGQIWGNLISSLIFQTESNSTITDEDLKTCGANFCPSSAANNSNLEKPAMEKVYTVCGIYIGCAVAAVVVVSLLLDPIRLDKEEPGDRKFSTHLIWETFRHLWKNNYQKLLVVLTMYSGIEQAFMTGDYTKSFVGCALGIENIGFVMICYGVVDAICSFAFGRLVQYVGHIPFFVLAFLLHGGLQITFLLWTPNPDMRYLFYVFAALWGAGDAIIQTQINALYGFLWTKNSEAAFANYRLWESMGFIIAFALQDFLCTYVKIYICLGFLCLGMLLYGVVEVSYRRDANNQAAVTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ET22</accession>
    <name>A0ABY7ET22_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GCS light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Gamma-ECS regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamylcysteine synthetase regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glutamate--cysteine ligase modifier subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_027288</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a catalytic heavy chain and a regulatory light chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="9">
        <location>
            <begin position="82"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR13108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="252" mass="28818" checksum="395481E5DE601FAE" modified="2025-10-08" version="1">MAEDIPVVPKAGSLLLNSGNIVNWNRLKRKPSQSPTISECIGTTFQAFINGSDKNELQYLTDLNCVHQKYKETVPKADRGDFKLTVKIFLCSLLPTDVLQEAVDKVLSELDVSFIETVIVAFPEVDNEELTLEVVQPYWKALETLVYRETVISLGLADFDKKLLEQLYEWAEVKPMVNQVNLESCCVMPKELVEFAKEKDIQLLTHNDPREKDGEGWDPLWVLRYSVLVKCRGIVKSKGYLLKAERDVRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EU54</accession>
    <name>A0ABY7EU54_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="239" mass="27027" checksum="56BF8621649799E9" modified="2025-10-08" version="1">MANFLDKEAMWDWLTSNLRRRCRRRNDRNQTRNQADEEPMSSGSELRNFLHRTREQNIPFFRPSNLSSGSPPKCLSRLTCSDILYGNRIEDFSTDCWLENRLHHFGLPERDHQLMSQSAALAPLFESDDDSITTSNDSNSIVVDYNGPSTVSGHGSSQNPARIALEELFIPLGESESDTDVDGPFNYSDIIDPPPYSEYSDDPPTYEEALAGNEGMANTARSRRSNTSRSTSSTLAFMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUA4</accession>
    <name>A0ABY7EUA4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CLP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_027060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd01983">
        <property type="entry name" value="SIMIBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="5">
        <location>
            <begin position="77"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="3">
        <location>
            <begin position="255"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR12880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="349" mass="38492" checksum="7ACBEE877CACE391" modified="2025-10-08" version="1">MTEKEELMSGKAEIFGCELASGRKYIFKAGSKVATEVAYTSQDTPNVVYLNMHVALEQMRQKSEKDHTRGPRIMVCGPTDVGKSTLCTMLLNYGVRLGRAPMLVDLDVGQGQVSIPCSMGAFTIERPSDVEEGFAQSAPVVFHFGHTSPSKNLTLYNLMVSRVADVINMKCDTFKKVNHSGVIINTGGWVKGAGYETLKHTAGSFEVDIIAVLDQERLYNEMKRDMPDFVQIILLPKSGGVVERSNHQRTEARETPSLPDSCLPLGMKSQDNRTKLVPLMPGTGLLHHVYSLSSAESTEDNVIEASVIGFVVFTEYNPDKNSFTVLSPASHPLPRNILLQTDMQFMDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVE2</accession>
    <name>A0ABY7EVE2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR12924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="366" mass="41584" checksum="665516C47D1B870A" modified="2025-10-08" version="1">MLPRRNEYFPHVRDSIQEFINRRPDGSRIQLFGVTDYNYKILDITKSNSSEIWSKKLLELKPGDFEYSHNGTVSSVLLNANLKDCFDHYQGLTQISVLIGPSTTMGVLNFKKLTFKSFVIQTDVPPSKDSLVTFATNLNHVFLVSESDELNKLIAEDTEHKCNTDKYWRSDFNTCESCKNKCSRASLTCENQDLAVECKYQIEEWTRLKQSTAGPTTSDPWVSSPFAQEPEKSPSSGWWRYLVWSLGGTLGVATLVVVLCRVKGMRRRREMTAMDGRPNEERGNDHRMLPDNRPVTDTQPHDDRLSREARPYVDGGLEVQREETQPLMKVADAIKAAPVHNGPFLDMHAATNIQPCPPSPRQEANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWL7</accession>
    <name>A0ABY7EWL7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_004452</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055175">
        <property type="entry name" value="ACK/TNK-like_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22931">
        <property type="entry name" value="SAM_TNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="30"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR14347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="235" mass="26759" checksum="E96901A7D78FDEB6" modified="2025-10-08" version="1">MDSGENSEWLYELLTEVQLDQISHFDYVKEEDLQKIGMGKPAIRRLLDAVKRKKATLRKKGILDKILPKVPEKSSSKKPSSQTSSLLDQTLTCLIPEPSLFLYDKLGNGSFGEVNVMHNLDHENIIRLFGIVLSTPLMMVTELAPLGALLDYLRKEQERILVCQLCDYAIQVAKGMCYLESKRFIHRDLASRNVLLMSTDKVKIGDFGLMRALPSQEDHYVCSRKPEDSTVFPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F252</accession>
    <name>A0ABY7F252_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="880" mass="101092" checksum="5628EB011EDE3A02" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2I1</accession>
    <name>A0ABY7F2I1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_030987</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF344">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="12">
        <location>
            <begin position="68"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="13">
        <location>
            <begin position="217"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="11">
        <location>
            <begin position="399"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR16393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="573" mass="64393" checksum="6B467942C235B5A0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5P8</accession>
    <name>A0ABY7F5P8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OV16-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR17475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="154" mass="17020" checksum="EFC6394963010274" modified="2025-10-08" version="1">MEAFKTEGVVPDVIDNLPPAVLQLTWAETCLSPGGRMWPRDVRSPPSVSYDAEPDSYYTLICNDPDAPSRADPKFGEFHHWLVTNVPGCRIEDGDERTAYIGSGAPKGTAEGRRKHSARKFAASHSLELVAGNFFLAEYDESVPDLHRQLGFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F6Y0</accession>
    <name>A0ABY7F6Y0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CCKAR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_005161</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF47">
        <property type="entry name" value="ECDYSTEROIDS_DOPAMINE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="23"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR15056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="433" mass="48977" checksum="417B4FB567C544DC" modified="2025-10-08" version="1">MEDPAVVTVMMMLSLFSICGTIGNSLVLYIYSHKKEKSTAGIFIMSLAGTDLFTCLFVMPFTEAVVYLNYMVRYDVACKIYMFFITCNVPFAAFIMVAIAIDRYFCICHPFLHVLNIFRAKVIVSCLLLVASTFGVITSLSYGVYTYKLIVPGNKARTNETKSVQYGHNTTSNTAGHYECTTCSNELEMDVWDYHVFDNNKTEMQAGYELSFTGICAPNYILTGPEFLNFYQRAYAGTYLLSFAVVFILYGLIYRSIYKHRANRSKRKRSSLYPSGVTSLLPPVSALKSLEWVDLKNAEKQFTAVTHVNPHSGRRSDPCLENGDGDVDVGKPVELQPLRPTAKNITRSISIKEKTLFANIRTAVMLCVVTVVFLVAFLPAWLMGLQAIGFNAVIFYMYFVYHTANPFIYAFMNKSFRDDLRKVLKCQSIPRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7R2</accession>
    <name>A0ABY7F7R2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipase D-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="47551" checksum="C773543398DE7B12" modified="2025-10-08" version="1">MEGETAIEKSVREFVFAKIQEQVWLDVAKSNTICVQSRARQGSTALAMFWLRVLRHKNNYPMPKYPYKEVYDKQGTNKVILKVDSIKITTLMRCGTLIMQGSWVLEWFLNTFPTIIEAYDAPERVRSEPSTVYKQYTESWKTLQESDALRKAETDREERIREDRSLEILEDRENIIQTDTAKAYDRMKEDKETRIKKLRQAVEAAAEESREELELMTLNVWPVDVLESQLRKLQTCCVRDGSTYIYRLWRSLLHNWLADPDRKVYIVTPFLDATRLTDICNIVIQHRIEANLDSIYVRQKCDENGFGTIQQVKKQTLDKYDAKEQMYIEYKIFSAMIYPFKRFHAKFIGCMKGNEAEVLSTSANFHGDHFDYSNMETVHYQKMSDVEFISKFLGPINASVHDIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F807</accession>
    <name>A0ABY7F807_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Shieldin complex subunit 2 first OB fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049507">
        <property type="entry name" value="SHLD2_OB1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21669">
        <property type="entry name" value="SHLD2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shieldin complex subunit 2 first OB fold" evidence="1">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="114" mass="12904" checksum="4E103CA0DE3EEEDC" modified="2025-10-08" version="1" fragment="single">MPHQRCRCYFSLQDSVATTVMVNDKEVNVRTITVEDRTGKVKVSLWRNIAAEPVVLGDVVAITNIVVNSKRYNNEESLWSTQFTKIEDSVATTVMVNDKEVNVRTITVEDRTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F816</accession>
    <name>A0ABY7F816_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Polyprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_031766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="3">
        <location>
            <begin position="117"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR17172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="27488" checksum="7EF5A23194A92FA7" modified="2025-10-08" version="1">MCQCPQTKKKYVVFSDASGLTIGAILSQEQENRVVVIAYASKALSTTQRNYCVTMRELKIHGWKLVTYHRSLICQMNHNICKRSVDNGICDMFVLREGVFYKKYIPDDNEYLTLIAPLEIRQEIFQLLHSHHTTGHFGRDRMTDLIRKRFYWPNIHDYVQRWCETCDRCAHVKPGPGVGKSPLKSIKSSRRFQIVALDIVGQPPITDNSCEYILVISDYFTKFVVRVAEPYNPYGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9H2</accession>
    <name>A0ABY7F9H2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_032261</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045897612" description="protein-tyrosine-phosphatase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="668"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="813"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="989"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR17667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1227" mass="135528" checksum="A47B99A0E25100BB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAC9</accession>
    <name>A0ABY7FAC9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MLRP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF142">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAM" evidence="1">
        <location>
            <begin position="116"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="283" mass="32895" checksum="ED6F7FC6E3322F90" modified="2025-10-08" version="1">MKEVRNFPNIPYHHHTQVYYPNGNMDKDSYVKCKGNEFDEQCRMPITDYLIDFENLIENHRYYFGINVPAHCNENILSKTKRSVKWKFPDYRCKRIPVNRPSNQVAGTDIIRVNESICTFEKDFCGWTRGTEGNLINWLRWKGHTDDKRRTGPTADRNNDKSGYFIYVDATRNTGRKAILRSPNFPIRTYCFEMFYHMYGVSSVLRSPQHTGTLHVRAHLGNSKKGKDIFTRSGNQGKEWLRMACTIKAELMNSTFYLTLMAEVGESYLSDVAVDDVSVTPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEL1</accession>
    <name>A0ABY7FEL1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZFAN3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_001147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050652">
        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634:SF67">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="227"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR19309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="302" mass="32720" checksum="016F6BD83E1FA395" modified="2025-10-08" version="1">MEESDSSQQPKRCSCGFWGSSQTSGLCSKCYKATVQEKTKEGLDPKSELMRNRQSAYANHDNVGATSSSFLPTGCNPSAASTLEKAEELIRQAVKQQTATENSSSSASRLFTDSQASKESSNTSDTGKNSEIVAPESSVSISKDDTDLVVKDSAKSVVTPSTSAKTTDSDAGKGDLSSSDTTSNKTVLDAKSSTSELESPEKRGVKRNSSALDCDAEPDSSPEKQGTKSKRRCNVCRCKLELAQRAIGKCRCDNVFCSLHRLPELHKCQFDHKEDGRQQAREKMVKPTRHLGTSFKRMDSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FG63</accession>
    <name>A0ABY7FG63_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045543931" evidence="2">
        <location>
            <begin position="25"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="211" mass="21143" checksum="DC003C2D7071D0A2" modified="2025-10-08" version="1">MNIKKTAVLLTALLLIDLMCLAEGQGYGRGGGRRRDRGWRGGGRGGGRGRGGDRGGGGGLLGGLGGVLGIAGAALGAAAITRGVTGMLGSGGGRGYVGGGGSIYNGGQYIPPHSHGVSQQYVPQYGGGSFYGMSGAVADPIYQGNVGGFGGGYVPPYIPQRPALAVAPAVIPSSQGSHNRGSRRVVIEENFDRGQHSNKGRPIVVGQPVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGD7</accession>
    <name>A0ABY7FGD7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HEPH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_002297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="2">
        <location>
            <begin position="257"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR20459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="367" mass="40907" checksum="5551815AD120707A" modified="2025-10-08" version="1" fragment="single">MFAFYKSHVCSPASPKIVPQPKLVPKAKGITRRYFIAAVEVDWDYAPVKIHPLTGDSLLNPNSSSYLYIRGGPNFVGTIYRKAIYRKFTDVTFSKMVPQRESLGILGPYIRGNVGDTIEVFFKNMASFPFNVVPRNLPFADGSEISSALPTLPGQIKLYRYIVPERSGPKLNEPNCVGSMYTSRVTPLNDTYSGLLGPVVICRPGILDINDQRSDKVTTEFATAFVIFNENLSHYSTYNFATSAPGRLNTSATDFVNSNSKNSINGLLYGNLRGLDFAKGERTAWYIFGMGSTFGIHTVHFHGQLYIRRTSQTLRGDVLEVFAGTYETVEMAGYNPGTWLFHCHVSLHSAAGMETVYTVHPRKLKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGX3</accession>
    <name>A0ABY7FGX3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="179" mass="21051" checksum="89C73AB22F82673D" modified="2025-10-08" version="1">MDRIPTRNSPYYRPDCRFRQFLEFVNRMFINHYTLRQIDSVDETLVATRGRTGMIQFIPSKAAKSAVKFWVLAESTTSNVITYTVSKYDCKTFAYWHYYHKHSSFWLIKLMSTRTCYMFESVLMLCNLAGYILHIKTYLRKTYEPSHTSLQGTYVVKSLDVHVSTHGPWLPGCQGQLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHL0</accession>
    <name>A0ABY7FHL0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297:SF191">
        <property type="entry name" value="PROTEIN XYLOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="312" mass="36043" checksum="28627E08F07DD612" modified="2025-10-08" version="1">MKSKRVNIAFVDSSDLKPKSYKKYDRSSSYGSQIKLRLSISTLSSSKTRLVTTARAYDSRWSTTDKRFTSVRNHSANKLPIIESWKRWSNAGPPPQGIVPTKGGVHIIACRGFVYTVLYDPRADVLLDREPETDEVVKPFLARYTNWFWDTLECHGKYVHSVCVHSARDLPPMKDTINFTKSFIPWHTIASRSCFLIEPGTDTSDLPVSIPLFIPILTFNSCNLKLSNYLSGIPERDEVVRPFLARYTNWFWDTIECHGKYVHSVCIHSARDLHPMKDTKKLFVNKFHQELHTLAYACLEELLFIRTRDRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHR6</accession>
    <name>A0ABY7FHR6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="1">
        <location>
            <begin position="47"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="122" mass="13827" checksum="14BA08106D8D3EEC" modified="2025-10-08" version="1" fragment="single">MSIYVNIGSIKAVSNYELPCDPLELNRLASWHPLTTLKKQKVTVRTNAFVWTDERMTWNPADYKGLNGITRSDMIWKPMIIFTSAFGEIVPIRNDAHWMPVNGLAPWSSGESISSNCPMNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FI45</accession>
    <name>A0ABY7FI45_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046133359" evidence="2">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="185" mass="18405" checksum="289F0851CB04377C" modified="2025-10-08" version="1">MKVILTFIVVFCAFGAVLGQWSRQQPYYQSGPDMTMALLLGLDMNDLFAYQALTGMGFGMGPILPKRPSARNQILRDITTLQRLGILEGGTDGPDPVGRRGGGRARGGEAAGEGGPGGEEAGGRGGGRRNQNRGGGGGGGGGGAAGAGGKRRGGGGGAGGRASGGAGSGGKAAPNRQRQRPVRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKI6</accession>
    <name>A0ABY7FKI6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_016071</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 12"/>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="15">
        <location>
            <begin position="88"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="14">
        <location>
            <begin position="329"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR22097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="845" mass="96727" checksum="BCD2B0226F97636E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FM42</accession>
    <name>A0ABY7FM42_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAR14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057044">
        <property type="entry name" value="PARP14_KH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF111">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23084">
        <property type="entry name" value="KH_PARP14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="666"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="595"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="801" mass="89846" checksum="435F68A991A4B08B" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FN02</accession>
    <name>A0ABY7FN02_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PWP2A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_016032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd20140">
        <property type="entry name" value="PWWP_PWWP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16112">
        <property type="entry name" value="METHYL-CPG BINDING PROTEIN, DROSOPHILA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16112:SF22">
        <property type="entry name" value="PWWP DOMAIN-CONTAINING 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="501"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR22058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="606" mass="67710" checksum="AB71DA2F3AD91818" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNF1</accession>
    <name>A0ABY7FNF1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_014715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="324" mass="36763" checksum="7A831E0B910924B4" modified="2025-10-08" version="1">MENFVRREVIRSQLEHLACRLAENGEECFVVTATNPNILGSDKGIAYCRILFQGIQRAFSRHVEAHQTADRDQAIEQGLETSTEDEQYVHSKLRTHLKIENPIRHESENDHCGNNYNDKGEPYPTPRKVETLASSRNKSTSQWNDRGKQPSKDNNTSKNMYKQSMSSSADSDSELLGIGTDEDSTNADSLLSESELLAESSKQETTGLKRTNQMDEDNSDMKRFKPATPSSRETISESLPELNNGINLNTVGPSTSGVQSTRQKSFKNRSSVNHHRKREHQDTEYKPQKILRMPLEELEKELKRNNDVSTSYNPDESSNENMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNM4</accession>
    <name>A0ABY7FNM4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR23830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="567" mass="64578" checksum="83C9B91C1ACCC65C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRD1</accession>
    <name>A0ABY7FRD1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_037261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR23592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="48596" checksum="068CE2984961E874" modified="2025-10-08" version="1">MVVVQWRHFRLQRNDIFFISLDMDRNVLLLLGLLVTLYGCEANPNDPSTLTGPTGDQFGDLRCPTDDNGMMVATFEIWRNNSATTRVYFSEPADPTVGSMGIPIDQSCCLWTGNGIPDDPFIFTAMVNTLTDTVPSGCDCGIKVLTANYMYQWTAYAQQVPNMNMEGDIELTITCNIDNGLLYTLQAQYTNVPFPIINIPAVTTASWELGLYRASAGTPEIGQGVSVAVGTEIKIRLTFDPPTFASLTNINEDETTGCSIQAELDSPFTGTRPSTGVTYQANTGNFEVFRFAGVPGDLGSVPNTLTIHCEAYLCWLPNDPNCIDRCAANQVRRKRQAEVERLDRPYVIQGVLTITDPVKTEKEQLEDESWSFETLMVPILSVVGVVLLVLVVAGVALCIRRRREPEFRKYSSYSESSSVQSHNNRHFPPSVEGYPRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSN4</accession>
    <name>A0ABY7FSN4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_037497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021403">
        <property type="entry name" value="DUF3043"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11241">
        <property type="entry name" value="DUF3043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR23828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="133" mass="15116" checksum="1B723EDD13621F29" modified="2025-10-08" version="1">MPAAPIKKPSAKIVATGRVISRDDILESLKAERLSKRQRREQEKREKDLERENLRRERQTFGRLVDKKYTCGSFIIIIIIIVIIIIIIIIIIIIIIIIIIIIVIIVVVLVVFVAVVVVVVVVLSSSPNHQTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTH4</accession>
    <name>A0ABY7FTH4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SSUH2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052789">
        <property type="entry name" value="SSUH2_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465:SF1">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="446" mass="50304" checksum="9B7462284ACBBE35" modified="2025-10-08" version="1">MSAYPPGGFDPNQAPQRWQPGMGGPAPQNPNMPQNDMEGTQPPQGSYGDPAYPPIQGYEGVKFGSMMPMPPPPMPQQPQGDPPPQTFTDMANLTEEDCRQAMIQFVSENCCYGSKPAKEMKITKFTGITAMHYVLETFAEGRSTGSANEPYRGGPIDGPQNGMAPPPWSIPCQPHQTFHDHDIKIEVPHTSVVSPCQACDARGWNYCWRCSGRGRNRCNSCGGDGKRMEYDAHRQQHVRRTCHHCHGDGRNRNSQYMSDVDLAFNIYYLDYDSFGQLTQHSLYIFVTHCLTASCFVGSCHTCGGDGRITCDTCDGFRMLRCFILLTVRYTNHKDDYILETSDMPDELVRTVGGTVLFEDTQPMVWPIQSYPVPEVNQNSQRLVSSHRSNWPSEKKLSQRQTLRGVPVTEVAYTWDDQHLRYWVYGRERRVHSPDYPQQCCCGCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUQ4</accession>
    <name>A0ABY7FUQ4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CSMD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_038461</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393:SF7">
        <property type="entry name" value="COMPLEMENT C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045111413" evidence="7">
        <location>
            <begin position="21"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="125"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="190"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="253"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR24792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="376" mass="41743" checksum="4D04A8A859DA91F0" modified="2025-10-08" version="1">MKLKRGYLLSFISLFGNCFCAGNFEGRNVALGKKPGQGPRSSANGEAQLTVDVRERILVACRVPDAPVHGMYLYPNTTSPREYVPFNSEIVLSCDTGISISKSNSDKRKCLKTGNFDKTDLICTGNCQIPIVQNGFYSTNSQRFVNGTVSSGMYIYLHCNDGYELKDQRQSLKCDADSLFVSTHPSCEEIKCNNLPSRFSNGFYTPPIKKDTFSYNFTFVPVCKTGFTLVSEQNRTCISKNKWSGSTPSCTQVTCQVPILSNGYYLSKKKLAVSLPTFETIQPYCHTGYLLTRSENLTCQEDGQFSRGNFECRSVTCSSFGKLENGILHYSDGFITHQDADIGKNYRFGVKVRASCIPGFHLTRGSTEQTCTENGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FV07</accession>
    <name>A0ABY7FV07_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EFR3A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_038378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049152">
        <property type="entry name" value="EFR3-like_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051851">
        <property type="entry name" value="EFR3_Homologs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444:SF8">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21052">
        <property type="entry name" value="EFR3_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="550" mass="63755" checksum="4F0E086A721351C6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVC6</accession>
    <name>A0ABY7FVC6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_011854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="154" mass="17716" checksum="B36285105D0E284F" modified="2025-10-08" version="1" fragment="single">MTIQWWMPSTKFLKYVMLEILYLEKVDEKFEVKREHVLININITHHSGHQFRKDDFVSYTCLNVNQATIKVDAKLWALGLDTRLEGHDLTASVSKYSEVRKPASARVSMATPLHSNMRATISAVDGTLPKMTLKLVRSMKYSEETFLVSPERGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVL0</accession>
    <name>A0ABY7FVL0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YMD3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_010898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="70"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="1">
        <location>
            <begin position="329"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="367" mass="43700" checksum="54CF28D3F8668546" modified="2025-10-08" version="1">MDDWKDYLKNIYYNPEHAAAFAGPQKLYKVVKNEGKFNIGMHRIRRFLHDQESYSLHKPARRRFQRNHVVSAGKDDLWMADLIDMVKFADWNQGFKYILLVIDTFSKYVWLQPLKYKTGDEVARAFEKIFTTSNRSPTKLITDKGQEFRAKKVQNLMKKEEIHYFPTQSETKASTSERAILTIKTRLMRYFSYKETATFLPVIQDIADSYNKTHHRTIGMRPMDVKVSNQEEVRLATYFTRNPKSKKQGPKLKQFKLKVGDFVRISHLRNVFTRAYDETYTGEVFKVHKRYYRGALPVYRLRDLQDEDITGTFYQSELQKTSYNENSAFKIEKILETKGKGLNQQYFVKWKYYPRKFNSWVKASDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWD8</accession>
    <name>A0ABY7FWD8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="11"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="97" mass="10387" checksum="0921273748C48D6B" modified="2025-10-08" version="1">MQLEPDLFEPNINPAFGPAMGGTVITMKGSNICIGNGRISAYVGNDLNLVAGTSDYKITIGIEDCKMIEVNKNYMTCAAPRNQPKASQPGQLPEVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXS7</accession>
    <name>A0ABY7FXS7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SC5A8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_037620</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="685"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="761"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="793"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="841"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="880"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="940"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="984"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1010"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1042"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1116"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR23951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1198" mass="132564" checksum="16BEC214B60AA065" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZA8</accession>
    <name>A0ABY7FZA8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="127" mass="13547" checksum="ADC47112261B3165" modified="2025-10-08" version="1">MQSSEDTDRFLPLIPEDPVSDADADPSDPSDDDYLPSEHVGWKLGANGQKMQSSEDTCTDMFLPLMPEDPASDADADPSDPSDDGNLPSEQLSDSEVDVSAGLHDDVIHVSRGSSGIELIPESSVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZZ5</accession>
    <name>A0ABY7FZZ5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098">
        <property type="entry name" value="AGAP001331-PA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098:SF16">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="141" mass="15976" checksum="FDE17BE547508576" modified="2025-10-08" version="1">MNELKKRSNNWTNSERHSALSTILNQHDSLFGKFKGATLGNKAKEAKWDEIVMEINSCGGTRRTVEEVRKMYQSSKQRDKLKDTHVLTGIAGGVESGSYSFIIENDHDSSQPETGACSRNNENHTYEVPCVFAEKMQRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2P2</accession>
    <name>A0ABY7G2P2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="196" mass="22663" checksum="54AD7C7A177127F5" modified="2025-10-08" version="1">MVRGNVSEFHWDSCFDTCIDTYVDNFTTSLLELCNVIIPNKIITVRKSDPEWMNNSIRLNILKRKRAFDKANGIIYIKTGLATIEYSQTILDDSNKVLPEYRPLKVVELIDSILKFLVIEITRALCCARIDDASNTEYQERRGICKDKFRPVVEKKSISYSVKNNIFSEVFIIILVCKNIYSNCVQCGQDHQSDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2S5</accession>
    <name>A0ABY7G2S5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YOR6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_014447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26392">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26392:SF92">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="2">
        <location>
            <begin position="61"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR28743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="459" mass="52765" checksum="DAAE9CF2CED808EB" modified="2025-10-08" version="1" fragment="single">MKASEDHEVVRRQLQEKIQQAHRLFQAFPLKLKSNLIQTYPSLEDDFKGNQKSLKNGECWILVAGEIGAGKSSLINLILDCQLLPTDAQKCTNTIIEIRCSDEKLAKCFYKPELSDSGDRTRKIPPREIRLNDLKGIQEFKDSVVECDENDDNPFQRVELYYPFKKLSKQVVIVDTPGIDGGNNVGRRLELYLNKSFGFLYVISTNAAGGLQQGRARDFYLNRQGQLKDHELLLQKIGQLISSSLRQGLINHYWWLSGFLTRSNYVLRVTSVQHEMTEDETRQRYKEMKKHVEELQIALQICTRRVYNWEDPRGCPQVDRKWKRTVDAAAMLISERIAMVIDGWQREHSVLSKIDKEIIDVFSKEFGLLQHQVDDIEKFLADNKGKAMMMKTVKRMTPKGIFGIKKGKVERTYNTMGGAVSCIGMLDTGNKNIRKLFKDRYTDKATQNQRAAVMAEATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4M0</accession>
    <name>A0ABY7G4M0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_014173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF147">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="10"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR28469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="151" mass="17199" checksum="5C537DA490564B60" modified="2025-10-08" version="1">MGTRSPQSTPFVHNLGTLHAGQQIIISGMPRSNASRFNISFDNSPNGPGSSDTAFVYDVRFNFGTDKQVIVRNSQQYGCWGHEERAIPHFPFQTEKFFEITVNIFRGGFRVCVNSGDVMEFKHRYKEQPLPKFCYLRIDGDVQLSKVAFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5D7</accession>
    <name>A0ABY7G5D7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">HR3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_003218</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805:SF2">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="28"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="11">
        <location>
            <begin position="179"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR29650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="371" mass="41639" checksum="EED8A42430476A08" modified="2025-10-08" version="1">MDDNLQPPKAAVNKAQIEVIPCKICGDKRSQSGPVNYQCPRNKQCVIDRVNRNRCQYCRLQKCLALGMSRDAVKFGRMSKKQREKVEGEAQLIKAGVQPGVNGYAHTELPSPNNNSHFTYNTDNYVYSPNGYVYGAGESTSPVSPPANAYSPTATPPTPVVLRTVDLLDNEAHQRTSPYSVETIAQLKATPVSSELITLYQNMTHRQVWAEVADKLTFAVQQIIEFAKMVPGFMDLSQDDQIMLLKAGSFELALLRCTTAYDGTTDSVIFGDRFVPLKAFSNLTEEEVLLQNQIFDLKLYEKITSALKLELGKNNREDENMITKLNQITWIVRNLNTQHINVLNKFKQAEPDVEFPALHKELFSVEGQDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8C8</accession>
    <name>A0ABY7G8C8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CLCA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="510" mass="54822" checksum="18BA9453804F02CB" modified="2025-10-08" version="1">MISLASDTGGKHFNYLDQGSISFAAVFSEAVSGGVTGAENQAVTLVSDSVRISTDRVHFAFQMETGLGKSTSVSVLTSMSATLNMTITGIGSFYDYSAVGKSLTGAMGHLEPGEYNVTVISSIHHTWDYIVKSFPSEPHPILVTSRLSTTKVDFSFESPDLPVLYVDVTKGKAPVVGAIIEAHVEASSILCTLSPKDNGQDPDSLEGDGVYSVYLLPKCLTNGRLNIRVTVKGQVNETTVINSINGALALDESEAKQEIISDGFQRFSLPEPIFVDRFQRSISDIVAPGQITDVNIVNIETQMTSNGESRNFTVSWTATGNDMNIGQASFYKIRYADDIDTIFNNFSSAYTLDIGNVSLTPKQSGMMETIVISVDAEQTYTDTAYLGIVAVDEAGNQGKVSNIVSIVVAKGFRISFEGETNYTETEDVIITFPATTVSQDVSTVRSNDEASHTGLIVGVSVGVFAGIVVVGLILSVVLRKRPPKSTYEVSRKSQTSLHEHANVNYVAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8H6</accession>
    <name>A0ABY7G8H6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="50" mass="5956" checksum="DDADD0E33E6CEC17" modified="2025-10-08" version="1">MKKLFTKRSWVTSFYSKTGIQLNINDSDDDVEMTYSLRKRGAVPEQKWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9P1</accession>
    <name>A0ABY7G9P1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="758" mass="89370" checksum="DF637782DF245182" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GDK8</accession>
    <name>A0ABY7GDK8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="89" mass="10086" checksum="DBA9BD2B041FAD1A" modified="2025-10-08" version="1">MNPSSVIYIMNPSSVTVYEKTVPPPFDVGYSRQPLPIPPPQRLPPLPPPQTEVYYQKPRSLDVALPVAAPEVVYNDAPRREQDVIYLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D8H4</accession>
    <name>A0ABY7D8H4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HS12B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_006140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ93669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="485" mass="54592" checksum="225E69707A3BE6B0" modified="2025-10-08" version="1">MVTPKAPTVVLFDKARRFHSFGYDAETKYNHLANEDEHEGWRYFRRFKMTLFQNNRLSRRTQIDDEQGQKMLALDAGIPDDQLTLAYEPEAAAVYCKEIKVALSTERGQTSELKSFGAGSKFMVIDLGGGTADITVHEVQHDGKLAALAAPSGGPWGGTLVDRQLNKFLIGLLGKDVIDKFSEECKPDKLDMDRMVEVKKRQINSSSDKVHIKLPNELFDLYKELKKKEFDKSLLSSNFSQTVSKKRDRLHVANTVFLDMFKESKESVINHVEAQLRHTDLRNVKTIMMVGGFSESQVMKEAIKERFEDKGYEVIVPEQAGLAVVKGAVMYGHNPDSICSRKMQCTYGISTAVLFDDRKHSRVHQSGRADGTEMCEDIFKTFIVKGDTVVPGKTSAEHTFNSPSAGNTRVTVEVYKSVEDTPPMYSSDCIRVGELALHTRSCQMDQKALIKVKMMFGGTKVTVEAQEQGTMQINKVQAEFDWLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DA05</accession>
    <name>A0ABY7DA05_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_006620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047155280" evidence="3">
        <location>
            <begin position="21"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ94149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="434" mass="47348" checksum="6640F79226116D54" modified="2025-10-08" version="1">MKTVLSLAIVFVILTSTCVAGERLKRDEATGNSFGDMFNKFMAAMFGTGNKNDDAAIDAIKNITADNGTNATNDTVIQKIFNDVTDSLTSETVNDATDDTSSPSSPSSSSSGSFTSESSSTLSSTSSTKSTSRSGDSSMMSSDSSASSTTSPNWITTIVEDTRCFSEAVLQNFCSVGADLVDVSFWDLYSVLFSDTVIDALMIGCTRGSWCLQDRFDYWEALVVERVDMVMNSEIAADMCRPEIRPCLDTVIENFRDCDAFLQMEYTVDALQLICDLKQNPSLTSECYKHALAALHVTLADIMRRNESSLQNAKEDICKSPEEHMTRGLICVTNSCPSEIQAFNGFGPWSWFTSVVDDLIDRCDLDPNKCLALLTPQAGRLYEGELGTLVGVSVVTMVTAVVLAIAVCTCYKRHRRNAVIKDGYQQLLNDVDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAQ5</accession>
    <name>A0ABY7DAQ5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="18">ITA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MAR_005940</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">MELC-2E11</strain>
            <tissue evidence="18">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF133">
        <property type="entry name" value="INTEGRIN ALPHA-PS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="859"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="260"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="322"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="15">
        <location>
            <begin position="370"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="16">
        <location>
            <begin position="481"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="17">
        <location>
            <begin position="656"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="713"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WAQ93469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="919" mass="102583" checksum="4FB31CE48CDA379F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAR1</accession>
    <name>A0ABY7DAR1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PI42B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_006167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ93696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="286" mass="32323" checksum="C86BAA5532B6494C" modified="2025-10-08" version="1" fragment="single">NSLTKQPQNVDSPGRSGARMLLSHDKRYFIKTLVSEDVEQMHHLIKQYHQHIVECHASTLLPHYLGMYRITVNDVETYLCVMRNVFSPRLPIHKKYDLKGSTVDRCASDKEKDEAKINIGAEAKVALMDQLTKDVTFLSNAHLMDYSLIVGIHDCDRIDPEVNDPTQNNSESDEPVSGEEENGVEYEEHVPDIGGFAPTPPDSPQPNFQVPAFDGDIDSNFEKFGIKSAEEVYFLALIDILTKYGMKKRTALAAKTMKHGVGAEISTVHHDQYAKRFLEFIDKCIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAV4</accession>
    <name>A0ABY7DAV4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="340" mass="38680" checksum="7804AEE029D06104" modified="2025-10-08" version="1">MKDKQSRSRGNAYSAPIYQRLPIGYTKLGPTLTVLYNKEGSVYGGYTGLSWQSSKLLLDITDDAHFYISPICLVAGHGPIFGNRSSPDLYTFFGEIQKSFSEEYNLNGNMDTKFGKNYKTGGTTSKEVNHGHIRVTELEVYAVKDGQRQKPNLPTTWRKSAEWGPKLLGSLKEDARVNRASEIWCHLFFAGEYHTGQELVETRKQMTSTSLISNDDADFQHRSKLSNKRTALYLFWTIDKLCDKTDENVSNTFISPTVKEVVEKVSELFKFPRNNIWPIKNYEEKVESDENVNILALLAVRQILFFVEDYLENMKVKQSRGSQKGKAKQAECELFGSDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBU3</accession>
    <name>A0ABY7DBU3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="271" mass="31110" checksum="F046841A61704697" modified="2025-10-08" version="1" fragment="single">MLAGEYMRLLNQMIQSGRKVDFTLTECTIEGDVRELHEKVGDQAALQVEAPQSFLTRTMTYIRLKKMTVSADVFMRLVLVVSQSRRLWDFTLTECTIEGAVRELHEKVGDQAALQVEAPQSFLTRTFSKIRLEKMTVSADVFMRLVLVVSQSRRLWDFTLTECTIEGDVRELHEKVGDQTALQVEAPQSFFTLNNTNIRLEKVTVSADVFMRLVLVVSQSERRVLCQLQNCTIEPVEEVRKLQVKMEDQPAIYVEGFSMCGQVWCIQFINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DC58</accession>
    <name>A0ABY7DC58_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LRP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_006761</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270:SF61">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ94290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="476" mass="54410" checksum="A9DFEA800C02CCEB" modified="2025-10-08" version="1">MKCLTKSMVCDGGNYCTKDENKNAPPCTIDECYQNGRFYCNISRKCIPEFSVCDGIYDCLYTEDEVDPACTKDECQNERYYCNRSTKSITGSSVCDGISDCIYTEDEVVPACISKKCIHKRSICDGAKDCLGGEDEVPPACTSKKCILMKRVCDGAKDCLGGEDEAPPACSKYNRQLNERIEPRRVFPVVVRRGQQPYRYRRRQSSSVYADINEETMEHYHYICEHNSPDHYDKVKDRQPCICSQCVEERVRPMADNISSGSSTIFVQPYATGGGSISSHSYVSNSAIHPRRIVTHYDSDSGLVRTKYCMDKSIFRRSVTRFEDDEFYSTGERKSSRRFTKSESDMYRICEKDNTKGINPRCMVAKHNRCIELVGTLDYMDIEALYQKTKSEDKRKLAAKYLDEGEEIFGFVGQIEREHIQANEVKECELLNNEIDNRNQGEHKESSSIKSQTELVEENFCADHSDLDEHLFSIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DC80</accession>
    <name>A0ABY7DC80_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_007117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cornifelin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ94646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="77" mass="8379" checksum="B7D1E9E689BBAACA" modified="2025-10-08" version="1">MNIITMGEWQNGLFGCFSNCGVCIMTYFLPCVTAGKNAEAVGKGCCLWGFLSILGPIGIYTRAQVRQLIREQKGIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DEH6</accession>
    <name>A0ABY7DEH6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_028101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ95411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="142" mass="16489" checksum="F3F3D7CE3ACF187A" modified="2025-10-08" version="1">MVQLFYYETRGKCCKKFLNHEGVSTKIHLFPYEGWAQPAMTSYWLLKTYWWSRSRVKITEVTGSQTYEVKGKIHCIKNGSTVISGKIKDKTNSDFRMYLTSNVDSADFQLGYCVTGTLERGRKKSEKGLSLTHYAMIKRRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DEP8</accession>
    <name>A0ABY7DEP8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ95207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="393" mass="45045" checksum="F93FCF04B77B5DDC" modified="2025-10-08" version="1">MKYILYVFVSESIYWNIIVKHEYRNFNTVTACAYRQLWQSALERECVETGGPQEHRRPGNPIVKRGRVHVSSPSKLSVVMLGIDSVSRSAAIRKLPKTLKYLREELHSYDFRGLMKVAENTYPNLVAQQVAPCGRGDACINQPCDGLPFIWKDFSASGYATIFAEDWAYEATFTYHRPGFRSSPTDHYIRNFWLALDEQESVGIFKKAQGSETARRYCYKDALRYRYILDYLKQFMSAYTDQRRYAFTSANSIAHQSRKLSKPAQGGISLFTEIPKDRSCAQAGIPENFCACDALKQYREGVQYNHSSIKWFATLFTPVNDITERYEVALKTVPGCGIFEVTYEVARNDEAVRVEDIVCINRYGGQAHCMPHSHLKIFCLCDDQNRTNSCSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DF74</accession>
    <name>A0ABY7DF74_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CALCR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="1">
        <location>
            <begin position="16"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="103" mass="11916" checksum="3FD9D56DA6E5C915" modified="2025-10-08" version="1">MAYQIDQEVLLKAEQQCMKRLEQYTPTEGFCNMTWDLMLCWEEAPAGTLVKNACPSHVKDISQTDNHVKRENANGDKTEVFTLWAYIRPCVIDDTMENAETRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFM6</accession>
    <name>A0ABY7DFM6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YMD3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013607">
        <property type="entry name" value="Phospholipase_A2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08398">
        <property type="entry name" value="Phospholip_A2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="139"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="297" mass="34422" checksum="2D6B7BC381C27D0A" modified="2025-10-08" version="1">MKCGKCVECGSTKTQFVKGAGAHSGSGVMNNLINKLPFEMHLPGHNFTGPGTNLNKRLNKDMTPKPWNVPINRVDNAAYHHDVCYAKNKDTEMDGIYNPSLRERFDRSIVQKIIGTKMNFGMGVKQLKKIVWTNQLANELHKPVNTKFQKRIVYAKDIDEIWASDLIDMQSFSREKKNVKFLLTVIDVFSKYGWMIPLKDKTGKSVADALKQILKERRPKKKWVDKGKEFYNKDVQNLVEIYSTENEEKSSVVERWNRTIKEKMWKYFSANSTNKYIDILNDLVDQYNDTKHSSIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGI0</accession>
    <name>A0ABY7DGI0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="79" mass="8819" checksum="7A0FF308A22E5E3C" modified="2025-10-08" version="1">MNEDVTYAQVNKIKTNRTEAVGPKTKGSESNLVYADIDIDHLETASKPSSRQRPPSPTEYADVDFFRTERGSNSDNIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHF2</accession>
    <name>A0ABY7DHF2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cGMP-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MAR_029782</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">MELC-2E11</strain>
            <tissue evidence="18">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="2"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12086">
        <property type="entry name" value="DD_cGKI-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05572">
        <property type="entry name" value="STKc_cGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002374">
        <property type="entry name" value="cGMP_dep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031831">
        <property type="entry name" value="PKcGMP_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035014">
        <property type="entry name" value="STKc_cGK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF111">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16808">
        <property type="entry name" value="PKcGMP_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000559">
        <property type="entry name" value="cGMP-dep_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0140">cGMP</keyword>
    <keyword evidence="9" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="16">
        <location>
            <begin position="118"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="16">
        <location>
            <begin position="254"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="347"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="17">
        <location>
            <begin position="607"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="632"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WAQ97092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="658" mass="75231" checksum="0BA3DF77B3CA77D8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHU3</accession>
    <name>A0ABY7DHU3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_029947</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="104"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ97257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="392" mass="45617" checksum="85CBC16ADD51D571" modified="2025-10-08" version="1">MKGIRRCNKHRRADYHNVKRNYVTLDADLRRELKYERQASSSRVTYVETEPENNKIYMNKLILSVRSQAFIRKRHNYRNSRTEGAMMSRSLDKEQVALLIADPQLQGWQDEHVFPFGNIARWDIDRYLWKTFSYALEYSKPDIIIFLGDIFDEGSKASDSEYAATLARLRGIFPQTSYIKTIYIPGDNDIGGEGRDFVHAWKSDRYEEHFGNISDVIRFGFLNVPSYTMSDKTLKAATEVQERLSAPLRVMLNHHLVTVEAKHYIYPVLKRLRPNLILSAHSHHASLISCRDCLHDNDWSWERQFQNLQFLDSYVHLNLNQSNSMHEIVVPTCSYRMGVSDMGFGLAIIGSEGVVDYTTLWLPRRYTMLIGYVIYMGISGAVLSVLFFSQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJV9</accession>
    <name>A0ABY7DJV9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GRD2I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_029581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd07354">
        <property type="entry name" value="HN_L-delphilin-R1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF3">
        <property type="entry name" value="DELPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="268"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="4">
        <location>
            <begin position="831"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="804"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="937"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ96891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1097" mass="122017" checksum="F6D5CA1156EC81ED" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DL50</accession>
    <name>A0ABY7DL50_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HARB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_022780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="35"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ98407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="198" mass="22872" checksum="6A2AA3E1CC129696" modified="2025-10-08" version="1" fragment="single">MAAIFVDLKQCDFRPGVIQSSPVQSRDSMDEQVLGLFQADLIVQHHAYIRAQAEDTPYFLLADDAFALRTNLMKPYSTRGITRSQAMYNYRILRGRRVVENAFGIMANRFRVLLGRMQQSPEVVQFIIKYCVILHNMMRRRYPGKQPGQFDGEVDDHNLIPALLELWELMEPVTDGLLLFGSEHHLCGLLFILGWKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DM63</accession>
    <name>A0ABY7DM63_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF6">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11783" checksum="9689BDA04F4BB1DE" modified="2025-10-08" version="1" fragment="single">MYDSLYGECNLMSQRMICACLIAFSGFLRSAELLKIKRSDIIISTAYMEIFIESNVRKYGFHSLRSGGATAAANKGVKDRMFKRHGRWASEKAKDGYVKDSLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMK9</accession>
    <name>A0ABY7DMK9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="477" mass="52549" checksum="24976A8AA1DA5455" modified="2025-10-08" version="1">MSTPRGSGGRNTTNRGRGGGVNTTGGHGGGANTHGGRGVGVQSGGQQRKSPVDVRVKPAESTDKKKSEGLNLTNLYTFLKGRLEHYKLSSKAQCTSIMNVIEIMAEQKTERSAEESQQLYQRKCKDLCQTLEGILNSNKDPVKANGDQPKDPPQNVGPKGTERRGTTGKGNAPTDIAKPIEKPTETMEDVEKLQLYQRKCNDMCLTLEGILNSNKDPVKANGYQPKEPPQNVGPKGTEGRGTKHTTGKGNAPTDIAKPTEKPKETIEDVEKLIKNVQQQMEERERELKGIPALVKNLKLECVRMCDDLKEPLPENIDIRPNEEEPVMFLEIKNKIDRARQAVAEILNGRAETELAISQLKEKNGQLDGDVKELTLRQETFRFCNESSDKQLASLQSLLLKPATFATKDSCKEAYIEQHSEPEEEQTPGKTPNPKRKTEDIAGHGDSMSCVDKYTHKCLQLSWLASVQTPPIYALSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DN78</accession>
    <name>A0ABY7DN78_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CACT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_022769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ98396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="226" mass="25485" checksum="57FDF0C2D3A327BC" modified="2025-10-08" version="1">MARAAIITLPRDTGMCMPTSHHLNQMFSDMKRQKKDNEQHRQYKGEINFDKQQDSMPRFTVATAADSLAVKALIANVIMTTDRDGDNFLFVAIIIRKTELAINLINLTTDYSQIRSVNKLRQTALHLAAITNNPKVSRRLVVAGAEIEMQDYNGNTALHIACIQGWAGVARSLIQHVSYEETKQNSFKIPYVLIPQNFEIRNYDGSPCLIIAICKGYLDIADMLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPR3</accession>
    <name>A0ABY7DPR3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_024062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ99689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36467" checksum="C39458148A32282F" modified="2025-10-08" version="1">MSALLDSVICGLPQSSTMSTVNNTTSGNESVVFRPSSGYDIPLYGLKNGVFYYIHGLAIGCLVTSLTCALLAIVFSLRQNNVRNFFSNWSKSERFIVYMATCDGLFNLTHLIDHVHITIVRDYVHPKALCAFYGFNLSFFIAAQQLLVNIIAINAFMLMFYNRHLNFGAGDWKLFLWTFGAPLVGATVAVAFEQYGPLGIFCFFDGVKGRLGELFFTTVPLLIILPVNCILYGLTFGKLHVRAKEIQQTLGPKSTTQRATYRAARSMSMFWWALALHGAWGQISRPVPNIFFYIVPIFTNLGGVFTLIVFIVIRRKPANSTGGCTIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DR81</accession>
    <name>A0ABY7DR81_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_024297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ99924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="462" mass="52841" checksum="FF1583BBC3A8871B" modified="2025-10-08" version="1">MYIVNCLMTPEEIQVRPCPKNHCMKQVPTVLLFDQNKKFHSFGYEAQKKYKELLDRDNHREWYLFKEFKMTLFQSKEAGILNEMLSLALEPEAASVYCRDDFPCVGKVGTRYILLDLGGGTADITCHRVEDGGLKELHIPQGGGFGGTDVEEKFKKLLVDIFGLAAVKSFKEKHLKEFWEMLADFEISKRKFDGNDQLVVNFPAQFRESFGEQEHIDDALQKAGCCKDIEIKRGRMFISKDKGQWIFDKTIDQVIERTQILLKVIGDVDYIVLVGGFSESKYLQTRMKETFGDKIVAPIEPRTAVMRGAVLFGQSPAAIQTRVSKYTYGIATMNRFKPEIHLEEKRIVIDGHEYCDDIFEKHVTIGQEITVGQNMKEMTYHPTIDNQAHAVLQVFASSKESPEYVTDEDCQQVGLVLVELNTDRKRDFEIKVKLIFGGTEIQVEVRDGHGKSIKEARMDFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRE4</accession>
    <name>A0ABY7DRE4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="280" mass="33072" checksum="FAD19A4676D56BF8" modified="2025-10-08" version="1">MEHLKIFSISQFVVISKFIEELNIKEPRNVQPKELVKFYENVHIYLTSLDYKVQCVEMFSNDFSDEHMNIFYKIHEAIRSYILKQKALVYKIEKLNTVQRFVDGHSKAKLRYVGGYCVAKLSTSSESQFSYENASVAVDVFNYLSEEEQYLKVQSSDQASLKEIERNQNLARSLTHVSDGAFDFFTNICYQCLTLLNGTNVIKHDKKLREMFDSIILSNVFVEDQPRMNRFLSNIYEEILNKFLMVFFKQFKKDLKSAYHVKKNLAHRKEIQTKKEKQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTC9</accession>
    <name>A0ABY7DTC9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="281" mass="32155" checksum="8BF907AA88B3A22C" modified="2025-10-08" version="1">MLADFEMSKRKFDGNDQLIVKFPERLYDIILYGNHESIDDVLQEAGCSEDIKIERGKMLISKHKGQWIFDEIIDQVIEFLFIMLQDAEYIVLVGGFSESKYLQKRMKAEFGDKVVAPTEPRTAVMRGAVLFGQSPASIQTRVSKYTYGIATMEHFKPGIHSENKRIVINGHEYCDDIFEKIVTIGQEITVRQNMKEMTYHPTIDDQAHFVLQVFASSTENPKYVTDEDCQQIGLLLVEIDTGGNRDFEIKVKLIFGGTEIQVEVRDGHGNLIKNARMDFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTU7</accession>
    <name>A0ABY7DTU7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_024455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF108">
        <property type="entry name" value="CLAUDIN FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR00083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="250" mass="29273" checksum="236A47F5D34821E5" modified="2025-10-08" version="1">MGYYERDERPRYPRSVIWIIAAVLLFIALVLHVVGVATDYWVNVLGIHSGLWRTCALGTCAYAGTDVTTDWLKGTQAVEIIGLLLGFIALLAISVILCFPKLYRWRAIALVSALLAGVLIIVGVIIYGAKVEDNLDYSFGLCCCAGDRSRTEYYSSDYPRELRAPAYDDRRYPRREYTEDNPYRYERRNEHDRYESPLYERNAYDGPYRGYDRPYGKTYKEYDPIDRPYGRTYRDNEPNYYSKTRRYDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DU36</accession>
    <name>A0ABY7DU36_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FREM2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="236" mass="25696" checksum="0BF7B2E72963B32F" modified="2025-10-08" version="1" fragment="single">TVYGRLDVSPIQLLDQNIYLYIEKVFVCAGQGGYIPLYNPDIGHYGCVGNAEQLDTVIRIMDKTDPSSVNTTFQGFPLSAMMSDDAQSSEVFNIPGADGFSFDSSPLFKVVFDRHNLKRSLNDIAGVGNGVKGTNMAPLILDFNGKSLVEDQFDSGKRTENNESQMPLISALIGASALLLIGIFVLVIFIRHRRKQTSPPPTPSGTITVMSTSPGHTKVISNAHIFNQSLPYHSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DU56</accession>
    <name>A0ABY7DU56_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BPAC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="510" mass="55838" checksum="489CE3D7684EC577" modified="2025-10-08" version="1">MPLNENLPEVYRKKCQTTERLPEGAHWSGLANSMRKRQPGEQGSFKGNIRRSLKGVASKPVSNADSNRKQLIQSRKDRYRTQQIKRDAVRERKLQNEGEFRRKTRENMQRKQGAAETFAAKKIASVIPKNTRPREKRIIFPAPLIPFPFPPPNLPPPPLYFHWPPVHIPPPPITPQFTLAILPSATAPHTQTLIFPAPYIPFIHPPSLTCPPPPLYFRWPPVHVPPPPVSPHFPLPVFLPPYTQHHTSNFPIYNLPYNTNTPTQPKQPNTTSTQPNTTSAKQNTTSAQPNTTSAQPNTTSAQPNTTSAQPNTTSAQQNTTSAQPNTTSAQPITTSAQQNTTSAQPIPTSAQQNTTSAQPNTTSAQPNTPSAQPNTTSAQPNTTSAQPNTTSAQPNTPSAQPNTTSAQPNTTSAQPNTPSAQPNTTSAQPNTTYEQPNTTSAQPNTTPTHQNTTFAQPNTTPTHQNTTFAQPNTTPTHQNTTFAQPNTTPTHQNTTSAQPNTYDHENVLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUD1</accession>
    <name>A0ABY7DUD1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">TRPM3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_024866</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1010">
        <property type="entry name" value="TRPM, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032415">
        <property type="entry name" value="TRPM_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037162">
        <property type="entry name" value="TRPM_tetra_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF1">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16519">
        <property type="entry name" value="TRPM_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="812"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="874"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="946"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1024"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM SLOG" evidence="12">
        <location>
            <begin position="134"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="13">
        <location>
            <begin position="457"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="10">
        <location>
            <begin position="815"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM tetramerisation" evidence="11">
        <location>
            <begin position="1149"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1218"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1319"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1496"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1578"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1218"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1234"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1270"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1341"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1496"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1578"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1595"/>
            <end position="1607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR00494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1655" mass="188826" checksum="D8802C7C00190902" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVP6</accession>
    <name>A0ABY7DVP6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PE2R-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="158" mass="17588" checksum="E262436998536B3D" modified="2025-10-08" version="1">MSKTVPIGNASGIIPVVGLGTWTVFGQQGNSDEVERATLAAIDAGYRHIDCAWNYGTQPGVGKALEAKIKEGVIKREDMFLTTKLWDTHHNPCLVIEELRDSLRQLKTDYVDLFLIHWPTALKDQDMSGETICPLDENGKGIPADHKLEDVWKMDTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVZ4</accession>
    <name>A0ABY7DVZ4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_008436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="3">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR01878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="108" mass="11899" checksum="D869F9AB88473151" modified="2025-10-08" version="1">MAEALVNDTTNTLRILLVGHTGHGKSSTANSLLGYNKKDKRGFASKKSAKSVTTKAESRIETRFRRDIQVVIMRGSVQSSETSNNVFQDQLKLAFEATNESGFDYSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DW02</accession>
    <name>A0ABY7DW02_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LRC49-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_023498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ99125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="527" mass="59608" checksum="846869F796710FCD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWF1</accession>
    <name>A0ABY7DWF1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-hexosaminidase</fullName>
            <ecNumber evidence="6">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_025398</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="6"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR01026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF21">
        <property type="entry name" value="BETA-HEXOSAMINIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045229314" description="Beta-hexosaminidase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="9">
        <location>
            <begin position="43"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="8">
        <location>
            <begin position="186"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="8">
        <location>
            <begin position="431"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR01026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="651" mass="74266" checksum="6A608AE07172A869" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWM8</accession>
    <name>A0ABY7DWM8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">POGK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="120" mass="13671" checksum="7C751024CE5E4CD0" modified="2025-10-08" version="1">MLGRHAVNDGTKLKPAIVFKRKTLPKEKLPEGVIVYTQENGWVNERVLLEWLNDVLFKRPGALLNKKSRMVWDMFRAHLVDAVKAKLKGRRTYQAVIPGGCTSVLQPLDVCLNKPFKSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWQ5</accession>
    <name>A0ABY7DWQ5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">STML2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_024901</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="4">
        <location>
            <begin position="32"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR00529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="373" mass="41761" checksum="224938F628128312" modified="2025-10-08" version="1">MLRTVSRCSRTEIRFAPLGLQQCRDYSERINHVIHFVPQQEAWVVERFGKFKRVLNPGFNLLVPVIDAISYVHSLKEMAIEVPEQHAITADNVTLKIDGVLYVRVRDPYKASYGVSDPEFAVTQLAQTTMRSEIGKINLDGVFKERETLNVLIVKSINVAAEAWGIDCLRYEIRNIDLPKAVREAMQMQVEAERKKRAAILQSEGVREADINVAEGKKRARVLNSEANRTEQVNEAFGEAEATIAKARANSLSVALVAKALSRNNGMNAVSMRVAESYVEAFSNLAKTTNTVLLPANTGDVSSMVTQAMTIYKKLSDSPNVENMNESDVDTFVKEELNKIVSDTSLDNPELDETIFKQDKRPGFSEDLLTELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWS7</accession>
    <name>A0ABY7DWS7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR01062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="425" mass="49860" checksum="2151F427AADB22E6" modified="2025-10-08" version="1" fragment="single">IHNALEFIKRDIVRGTETWLKGVQQERILRIMPYSLARSSRANSQFNGTTSQMEWEVAFSSEQVYIATWFLMLNPTLQQTANSHQVRVLYIEKKKIFILDARIVSPDFMNLSYTHITSLQKRETSATLNAHRLTRTPCKWKRELQTEFTVSTKISRTLYLQQTKAITCEVFRNCTWYQDHTMVVTDIDVIANILNSDLETYRGSKNYDMTQLTFEIISTKNRTSNQCGTSSKKYIIKSVEKKESSKMRKKMKSFSWLINDFNIMIKRKSRQYNDDAEKTENSLSVTSFQSSCFKQLRHCSENVGERSRSPRFNTLTPPYRKCEGQFNVNKLECVQRKPARFIMGDYKTSEEECFSRILDKLKLTSLQEHLTATRLIFLFQCPRVWCQHYPRQSVSNQHRKGGILRLKKILIVLHQISSKPSNKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXZ8</accession>
    <name>A0ABY7DXZ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="133" mass="14188" checksum="CA15DA70B227590C" modified="2025-10-08" version="1" fragment="single">MILPPMFLGTVRYVSVRFGTVLLGAMLAVFLGYRITSVIGSVLVAVGFIVASFLDEEVAVTVLSAGVGGIGTALLRVAAIIAVLEYFDELRMRAIVLSGMGAVLINFLMIGITFIDGIDLNWTKTFKFQAIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYV3</accession>
    <name>A0ABY7DYV3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABH15-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_007897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF93">
        <property type="entry name" value="SERINE AMINOPEPTIDASE S33 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="122"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR01339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="410" mass="46796" checksum="B3C513265104A6E7" modified="2025-10-08" version="1">MFFAVYSGITSIPIIVAIFGTIIVSGFIYVSSFLKPSSTIPKLYFKESALASHLLKRCRLMNRKFDPPWYLRNEHVQTIVSYLIPKISKEFDREYLQIKDRGVVALDWALHVSVYKRKRCTVLIILPGLTASAYDVSNMCSLAAHKGFRPVVFNPRGFGNSVLTTAKILSTGDPYDMREVVKYIHGRFPKALVSMVGYGTGCSIMLSYLGEFGSSANICASACISACFDSPERISKGIQGIYDIFYMLKLKFILNAHSKTFSKIVNFHELLNCWSYKRFEEILYSKLYNISSVDDFIERNNPLRDADEIAVPLLFINSLDDPFYSKMKIPYELCKYYPHILMVSTNKGGHCGFIDKLWDVSWAETLALDYLDSVLDFTNKGHRINYDFEVKDISLIEDLFKLKAMNSEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZ72</accession>
    <name>A0ABY7DZ72_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HARB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_009608</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="41"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR03050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="164" mass="18107" checksum="FD3AA1326289C424" modified="2025-10-08" version="1" fragment="single">VVDAIKQRVNNIKFPTTQADLASIKQKFYQVARMPNCIGAVDGTLIPIIAPRVREDIYVCRKGYHAINVQAVVTPDMRFTDVVDQWPGSTHDNTIFENCGLKACVEANNVGWLLGDAGYALKLYMLTPKANPAYDPTGKCIQLGTQPYQNGSGKSVWFVEVEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZW1</accession>
    <name>A0ABY7DZW1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="149" mass="16078" checksum="314D694BC4252E31" modified="2025-10-08" version="1">MLNRNHVLIPQHASSGGLSNFGYGTLQTDQSISKETQKSTLVDDRLTKSSDTVKPTNINSRNSFIIKPIYSTNSMKSANSNILKLGSNNLGRSCQAGPGNSTAQSLQSGNKSGSKKKKSVKLTQRLGNMLKKEQHKQHGSSLADFLSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E150</accession>
    <name>A0ABY7E150_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RASH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_008655</name>
        <name evidence="4" type="ORF">MAR_008707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR02097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR02149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="235" mass="26517" checksum="F90E13107F0898AE" modified="2025-10-08" version="1">MPIASNEQVLLTPGEANTKWVIQSTDENEKKKSLTASIAIWETCLTLPEARMTEYKLVVVGAGGVGKSALTIQLIQNHFVEEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAVNNAKSFEDINQYREQIKRVKDADEVPMVLVGNKVDLQSRSVDTRQAKQVADSYNIPYVETSAKTRQGVDDAFYTLVREIRKFKDKKGKSKKKPKRACAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2B8</accession>
    <name>A0ABY7E2B8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TEX52-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029206">
        <property type="entry name" value="DUF4532"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35156">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35156:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15046">
        <property type="entry name" value="DUF4532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="285" mass="33182" checksum="01F06FA2B468D13F" modified="2025-10-08" version="1">MLTANMPTIEERENLMKPQDVHHPGFHPRPIQRLAVRKPPKTMLNIECNHYLRSNTETFAHGHPTVEYKLWLEAGKHDAPFPQRPDESFNANVWRNFRRQYGFHTSAGGKMSDIIAAMYPLNIPSPSKVGQQTFEKYIRETRLFNDDKFKSMAMSRTKADLEEFRKLRIKSMSRNPPIDEQGHILPPENFKKYEPHLIKPVERPPTPPPANQKTDSLGQRYVPKSRPHLWKLSYKINNPEYDSVKKEIRKRKELEGRMKERERQSPGHQIGQIAPSPVNPPASIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4Y4</accession>
    <name>A0ABY7E4Y4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-ACP thioesterase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049427">
        <property type="entry name" value="Acyl-ACP_TE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34487">
        <property type="entry name" value="ACYL-ACP THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34487:SF1">
        <property type="entry name" value="ACYL-ACP THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20791">
        <property type="entry name" value="Acyl-ACP_TE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-ACP thioesterase-like C-terminal" evidence="1">
        <location>
            <begin position="116"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="199" mass="22737" checksum="3CF38ACC1410F450" modified="2025-10-08" version="1" fragment="single">MDTKFSDQPDLESIQPERLIKYRVSDDGFAAEVLLPGFTYTDFDQKIGAFSFNILLSDYRSGETLVKAEMSFVYVDFKTRKPCPFPDWYNQLKEGQELTKPSERLVTPDIPHEAFKFDLQSAFSDIDHNGHVNQSVYVKWCTDAGTEAALKGHYSGFKGNIGTYPMNTFELKYVGEVLANEPVVISTWQDKDNHLVLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5V7</accession>
    <name>A0ABY7E5V7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="116" mass="12819" checksum="52E462641ACE0B4D" modified="2025-10-08" version="1" fragment="single">CIFLKRRKDIAVNTLEIVENHSDTASENGVVHMETEGVQYAVVQRQAASQGIELQQQRNGDGLAYAELDIAFLQEANARVPARRTNTPTEYADIEIPSKLEPALEDPISHNASMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6G3</accession>
    <name>A0ABY7E6G3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CHIA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_010567</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR04009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="5">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="5">
        <location>
            <begin position="213"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR04009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="406" mass="45391" checksum="FD76001DFD3BC507" modified="2025-10-08" version="1">MAYDFHGPWSQVTSFSSPLYSRGSNTRFNQQYSQQWAIDRWISGGAPRNKLVLGLTGIATTFTLANITDAGVGAAVAGPGKTGPYLGHEGHATYYRVCELIRNGAVYRFDEEQKMSYAVLEDQWAGYPTPKSMKEKVRFAHSRGLAGTMFWSLEVDDFKGTYCNAGQFPLLTAVYDTIQEMAPYAASGQLTVRTTERPQITTVDIGLQHKTNKNGIHFYDMVDSAQISSLNFLLLISCIHLIYAFANMDVVDLKLVKSEIGDDNGSLINKQGRYFEFNKLKIRNSELVTLLSIGGANGKGWFQVVASETSMQTFAKNVAIFLRDRDFDGIDLDWEYPLELYRNKFTQLLQYSVFTIAIDSACATSLQVFRRQFEIEAMQTSKPRLLISIAVGVSEDTISNTDLNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E814</accession>
    <name>A0ABY7E814_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_020430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="34"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR05061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="291" mass="32742" checksum="417825265AC87832" modified="2025-10-08" version="1">MSSNSKFVLHVHFFFRSSRFANNAFGQYNRKNPPESVSIRHESESGTVIQSEFRVIEGNATRLFCSVQSQPVSSFSWSGAGFHSRDPPKLQALPRKNALEGNGILIQCSYTVGNPMTTKFEVSAFPNQNIVTINESERLSIVCEVTSNPNSTIRLKQTHMTIALMERDNVLGLEYAIQNASCSDAAVYTCAAFNNYTDMERASSKDMQLFVRYVPPGQNGDSADNPGYDAAEMYEQVQAKKETPVYDDLNDGNDRPDHSHLYTPLEESNPRSSIHYENVKREDPIYHNMVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E863</accession>
    <name>A0ABY7E863_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="174" mass="19695" checksum="CF63AA5B533D9A34" modified="2025-10-08" version="1">MGRTSCQSSSGTQNPKGMKPSITTMIENLNDKSTGRTDEHHNNKMLAWCVNSFKYSVECLFLLDNTRFRTAFIQPVKKESTKMKNEWSDWSENETNMLMSQEDTINGQTTNNYDSKMANTPKEAPNNSDSKLKDNEMNNLSENINVGYLSAEPKINNKSDIIDSETKSLTNSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8I5</accession>
    <name>A0ABY7E8I5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAR14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_020636</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF67">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Macro" evidence="7">
        <location>
            <begin position="500"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="7">
        <location>
            <begin position="694"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR05267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1250" mass="140636" checksum="151499CF0CC8A080" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8N4</accession>
    <name>A0ABY7E8N4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="142" mass="15895" checksum="5A65F3D4E3AFF311" modified="2025-10-08" version="1">MCRSEDRTLLIQFVTINGNNLKNENIQVEDITSHLTIYINTHLLTGAPTANEQKMTKCSVDIKMSAEEVGIDDQLERFNNDLVVNNVPVIIFIAVVCTIGIAGNSVAFAFYRTRMSRSVNTLFLTVLSLNDLLTSFILLDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E938</accession>
    <name>A0ABY7E938_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="68" mass="7883" checksum="4A4EF32C31F797D3" modified="2025-10-08" version="1">MDVAVREKSSQPQKLTITVPEMVAIDDVEYDDATDNDEFDKDIRQIDELQNQNDNVELPEDLNIENIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9B6</accession>
    <name>A0ABY7E9B6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MAR_010304</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Endoplasmic reticulum membrane</location>
            <topology evidence="2 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="508"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="531"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="646"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="15">
        <location>
            <begin position="169"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="16">
        <location>
            <begin position="399"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAR03746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="700" mass="79370" checksum="0EB52AA011F7919E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBB6</accession>
    <name>A0ABY7EBB6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_021392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR06023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="172" mass="18959" checksum="5000F9FA1AA06382" modified="2025-10-08" version="1">MYSDGREATYTVPILNPYASGIAFISMQTPYRWKITMKMDTVKHMLCKSDEEVVRWTDTTTATTASATSTTTASGWQTQTKLSFNPLPGRHHADESSNAVSPDKASGLTPRQIIGVAIDVIAGVITLCVCVYIARNDIVTSEMYQTKLVRDSSIGFDNALFHKDREDSVSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDB5</accession>
    <name>A0ABY7EDB5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-(apurinic or apyrimidinic site) endonuclease</fullName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_017975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd09087">
        <property type="entry name" value="Ape1-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00195">
        <property type="entry name" value="exoDNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF6">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="8">
        <location>
            <begin position="138"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR08017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="354" mass="40236" checksum="AA7726CE8EA975C8" modified="2025-10-08" version="1">MRLLIQMDENEIESKVQSRSVPLCLQLFNKEKYKIIRHLTKSLLIKAISKPLFVQPTSQLSKMPRGKKTKEETTEQVEAETTSPKKAVKKKAEKSGDADGEPAEEKSKLRKESSLTKGMDFSHTCQTKDGRSPNWKIASWNVNGIRAWMDETKCATEDIPSDVKVPGYYDYWSSAEKAGYAGTAIYSKTEPIKITYGLGIPKHDDEGRVITAEFDKFYLVTSYVPNAGRGLPRLPYRAKEWDVDFRNYLNNLNKTKPVVMCGDLNVAHEEIDIANPKTNKKSAGFTAEERQGFTDLLAEGYIDSFRELYPEEKGARLDYFVLSEKLRDDLCDNVIRKDVMGSDHCPIVLYMAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDG1</accession>
    <name>A0ABY7EDG1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LOXL4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_016724</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045465664" evidence="3">
        <location>
            <begin position="20"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="180"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR06766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="293" mass="33015" checksum="8B88AE5A4D3872B4" modified="2025-10-08" version="1">MLYMLAVLTVLGWPEGAAGQVTTMTIIPRQFKYEKACFDMYYGQPQSGWDYYETRKVVLNFDVMMVRSKAACQMKCFQAGPTCLAFFYRPTASWCRLNEIKHENRTDVGCSGNELVDYAEETESMYNKYRIDLDHLQNKALWTASKTDEQPLRFAPMPKTYCTVNENCTNAVDVADGERWRLCDGDGPGSCNPRKGRLEVEYQGVWGTVCDDSFYGAIGTINMNIACRMFGYMGGADSLADDYNRAYFGEGVGTIWLDEVYCTGTETLLSSCQNMGWGNNDCGHLEDQGIVCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EF68</accession>
    <name>A0ABY7EF68_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="73" mass="7856" checksum="E8C49F8252BE8961" modified="2025-10-08" version="1" fragment="single">MNPAVTRARVLPDTAGISAKQTTMTALQTRARIVAHAQTGSTHTHARVSRVIQEQTVKQVSTSDASMSKLLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGC6</accession>
    <name>A0ABY7EGC6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="831" mass="93709" checksum="5310DC5AE70DCEFA" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJF3</accession>
    <name>A0ABY7EJF3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="82" mass="8891" checksum="7FC75DA5199601D4" modified="2025-10-08" version="1">MYDMFANVTDERLIGRDVSVLCKWEKKVDKTWGEVADAVNAVGNGPRTVVQVKTKKAKTDYTAEQTSLGKTGGGPALPEMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKU4</accession>
    <name>A0ABY7EKU4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LRP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_018977</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046054827" evidence="10">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR09019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="111" mass="12206" checksum="6DE79E982C55B83A" modified="2025-10-08" version="1" fragment="single">MFVMENLAQIFLLFLSFVVNGYCGCPGNVNQTKALCGADEFQCEEDGSCISKGYRCDNSPDCSDESDERNCKKEMCSEGMVACTDGNGCFRESDRCDNVSTCADHTDEKDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKU6</accession>
    <name>A0ABY7EKU6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SNO1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_019324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR09366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="271" mass="30659" checksum="856A0D5F10CDA41B" modified="2025-10-08" version="1" fragment="single">PDRRICIIGAGPSGMSTLWHFVGLGNADDVVCFEKQATWGGLWNNWKTDHFGKLSPSFGPRAIIRDYIEGKWSKGANGTLKDYIKFNTAVKNVKYLDDKKKFIVTVEDFSNKETREGFFTHVVVASGFPGKVLHSHDFRHARHFTNQRVLLIGVGYSAKTVMLAHRTAPKSASCAIPDTIHESPNVKYFENSLAFFNDGSSMEYDAVIFTTGYRNHFSFLGVVDEVISFYPAGLYNGTLFFKEGHNNLFYVGIESQIHTFTYFEALAYWRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENK0</accession>
    <name>A0ABY7ENK0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FGL2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_025750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF5">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045150817" evidence="5">
        <location>
            <begin position="21"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="6">
        <location>
            <begin position="201"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR11570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="434" mass="50625" checksum="0D2F2E3D8F12BBF5" modified="2025-10-08" version="1">MKILRLVYFFLLTFSCGELARMKRKIKTHRCKYTFVVNEMDAADCPNSLPSLQADREAQVSIPVNPLLPLRAPERISQSSGEVKEWLSNMEKQLYDELQKTRDINSTLSRHEHSLSKAEKLLTEYQSNFTTVFRMLRYLENTILTHGEISKNLDKKLSGVMLDVVEVNNVLSKKVVTPDGIIQTKNIEVQSVSKVPSCSISPESVVFRDCADVYERHKQSGIYYVTPSYASCPIPVWCDMDTTIGGWLLILKRVSGNINFNRLWNDYKEGFGDLVDEFYLGNDNIFLLTNQKQYEVRIDLWDFSGNRVYALYKTFYIDGERDNYRLHIHSFEGSARDALKSHDRVQFSTADRDNDEYQGYNCAQEWLAGWWFNNCWFSFLTGPYYNISKVRYRGISWNDWKHEQLPHIEMKIRPSRLIIPMPDLQLTETENKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPA2</accession>
    <name>A0ABY7EPA2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016133">
        <property type="entry name" value="Insect_cyst_antifreeze_prot"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51156">
        <property type="entry name" value="Insect cysteine-rich antifreeze protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="68" mass="7553" checksum="5EDD3FF884741CBD" modified="2025-10-08" version="1">MECPPPLGSPPPTDCPPQLDCPPPLNCPPSLTCSSQLNCPPPLDCTSQLPLFKLEYWAFIKFFVEKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPK8</accession>
    <name>A0ABY7EPK8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GPX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_035960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF88">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046919596" evidence="7">
        <location>
            <begin position="23"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR10884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="136" mass="15014" checksum="F0FC049F76977055" modified="2025-10-08" version="1">MFGESAVRALLTVASLVGGAVGAGDRDGINPRQVCRPSIGNETAYDFQFHNVFSNATFDMAQFRGKLTLAVNSLCPATTRRIVTPALYSPVFMEDIRWNFEKFLIGPDGRPIYRYSPDTEPATDAQMHADIRKLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETI6</accession>
    <name>A0ABY7ETI6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="473" mass="53087" checksum="02DACAB7766A7936" modified="2025-10-08" version="1">MATEKEEISMSKKILKNALPIVTKPEKEHLIVAAIDFGTTFTGYAFSTKKILDDKINCSLFRSEGFQSEKAPTCVLLNSDETFSAFGYDAEEKYEELCLNNESDGYHYFERFKMNLYKAKAEIRDDDIKLALEPEAASLYCNMQKLCKIVKFDGKVELDSFPVGHRYIVADLGGGTADLAVHEILDDQNLREIARSDGDAYGDAFEACSVSYNDTVREANAKYTGKAEIKRDMFKFSADIMKCFFDKAVDGIVKFIKELRSNDELSMIHTILMVGGFSESKYVQERIKNDIRGVRLVIPIDPSLAVLKGAVLYGKNPQAITERMARYSYGFSVARSFKEETDPEELKITINGMQYCKKVFKKLITKGEVLKKGEVFGNIMGHTVETNTVLSFMLSSLLPAVAKVYKSTKEDPKYTTTEEECEELGKLIIHPPPSGWPPVSVLIQGLIVGDSEMHSFACNVKTKQIYAAKFDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUG1</accession>
    <name>A0ABY7EUG1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RANB9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_027052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RANBP9/10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="20"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="4">
        <location>
            <begin position="265"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="389"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR12872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="635" mass="68992" checksum="2B56710D85AB3A65" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F013</accession>
    <name>A0ABY7F013_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HMCT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_004346</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025155">
        <property type="entry name" value="WxxW_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13330">
        <property type="entry name" value="Mucin2_WxxW"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="181"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="1610"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="1813"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="2004"/>
            <end position="2151"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="2219"/>
            <end position="2368"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="2383"/>
            <end position="2509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="724"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="767"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1019"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1440"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1589"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2166"/>
            <end position="2196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="733"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="769"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="808"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="830"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="891"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="952"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1019"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1061"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1108"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1132"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1152"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1176"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1194"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1204"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1451"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1589"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2181"/>
            <end position="2196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR14241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2739" mass="290890" checksum="13D051367C27E5BA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0Y2</accession>
    <name>A0ABY7F0Y2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="269" mass="29915" checksum="B48E4AB79E416218" modified="2025-10-08" version="1">MSCLPVCRIVAESVGRHVVFACLLDCRRVGRKTCRVCLSVALSPSRSVDMSCLPVCWIVAESVGRHVVSACLSDCRRMPDGAVYGIMTDGNIYSQLSPQQDYPSPKTKSRSKSYWWDRSTLRVQVEFFPPVVDHGRELAGVVHALYFARHEVTCGNTGTFHENDVFYVLDLFYNDTALEVTVDGKDNDAIRLPVTPHMGALRGTLQYHVAAIVFYRMYKKYCKDLRQSTAMAAPAEVEYNFLGNTGVKVSNLGLGTMTFGSCTDVMVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2P8</accession>
    <name>A0ABY7F2P8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">IF2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_005113</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052459">
        <property type="entry name" value="TNFRSF_decoy_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23097:SF181">
        <property type="entry name" value="CASPASE-8-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23097">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="440"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="320"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="755"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="934"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="934"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR15008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="993" mass="109976" checksum="5CA329FD65BF434E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F462</accession>
    <name>A0ABY7F462_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="130" mass="13978" checksum="7D4B99511EFABA19" modified="2025-10-08" version="1">MLGYEYLHEDKGSGTNPVKLSEVTERVMAVVGENSPNIVGLGSGLDSTILQIQSSNCSAVETPSQLSHTIELCEEPLQPVQDMSTSYPVNCSGSSSSNNTNNNGCSHCSTCMEIMALKKRKLQLEVQLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5E3</accession>
    <name>A0ABY7F5E3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NHL repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="65348" checksum="C4746DEC78DF5AD8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F633</accession>
    <name>A0ABY7F633_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="149" mass="16845" checksum="C24A7BAEDBC2BE4B" modified="2025-10-08" version="1" fragment="single">MEVCIWCWRCAAEDGGVHLVLEVCGRRWRCAFGAGGVRPKMEVCIWCWRCAPEDGGGQLVLEVCARRWRCAFGAECVRPKMQVCIWCWRCADEDGGVQLVLEVCARRWMCAFGAGGERPKMEVCILELEGCIWCRRCAAEDGGVYLELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9B4</accession>
    <name>A0ABY7F9B4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Pyruvate carboxylase</fullName>
            <ecNumber evidence="3 11">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MAR_000606</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="3 11"/>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="15">
        <location>
            <begin position="55"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="14">
        <location>
            <begin position="160"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="16">
        <location>
            <begin position="568"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="13">
        <location>
            <begin position="1134"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAR18768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1208" mass="133871" checksum="210E05B2E31774CA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9J7</accession>
    <name>A0ABY7F9J7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NEMF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_000691</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="7">
        <location>
            <begin position="399"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="8">
        <location>
            <begin position="896"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="510"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="674"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="200"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="510"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="704"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="725"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="776"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="833"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR18853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="997" mass="112976" checksum="2B46C9BC09DC3642" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAM7</accession>
    <name>A0ABY7FAM7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FANCL UBC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd23831">
        <property type="entry name" value="DRWD-N_FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043898">
        <property type="entry name" value="FANCL_d2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18890">
        <property type="entry name" value="FANCL_d2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FANCL UBC-like" evidence="1">
        <location>
            <begin position="45"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="100" mass="11715" checksum="27383E6D9F16C1B1" modified="2025-10-08" version="1">MNILTDFPYLIPQEPDGFHYNGYISIKERQLEKETGFEESSSQLCRQLITDIEDLGWEKLAYVDDDFQEIHLAYTDSDGRTHVLKLYINKQAMTVKLIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FB70</accession>
    <name>A0ABY7FB70_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR17933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10715" checksum="D24F88766859ABFA" modified="2025-10-08" version="1">MNIVESNKLQMKPVPSDAPVTHLCAVCGKSFLWNHSAYVHMENRSCEICGRKFGKHCDQRSHAQVKGQCTQCFNPYGVDVCLNHVSTKFSWRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FC89</accession>
    <name>A0ABY7FC89_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CPAS1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_000131</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="410"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="5">
        <location>
            <begin position="1168"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR18293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1408" mass="157069" checksum="243B53D6142CA02F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FG72</accession>
    <name>A0ABY7FG72_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S39AD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_015134</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR21160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="254" mass="28140" checksum="7EB0ED6610FC6FCB" modified="2025-10-08" version="1" fragment="single">PAARLKLLLSYAVGGLLGDVFLHLLPEAWQHLDKGGHDHDAHIRLGLWVIAGMLSFLIIEKMFAKEGEFDHLEDECEEAEEEMNHHDNHISTPTQSQTDSVSNNTRKRAHLQSKNGDTVEHKKQNGLKKNNADNISNSSKSASVSHTEVKEESIKVSGYLNLAANVGLITTLAILLHEIPHEIGDFAILLRSGFNRWKAAKAQSTAWILPFTSGGFIYIALVTIVPDLLEERHPKESAKQIIFLIAGVATMYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGV7</accession>
    <name>A0ABY7FGV7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="216" mass="24220" checksum="7EC730117FDCD023" modified="2025-10-08" version="1">MKRVTGTDALAIITIRVITSEVPHQSHKHQYGGEDVEEEYFCHTSNTSLLMLSKNEDYGANSALVAARSSAEWFLLDVVEPIDVAVVTDGVDCDSEQVVDEFSETKRFAACRKSSEALNWLLIFLIKKHYCRHVTIVGKSSKKCLSFGVAKKLQILQESNQKKSSSIEAQMREELDGLFKSNGAIPDTKMPSGFEKKSPRGKCIYNGRRHVNLYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FM04</accession>
    <name>A0ABY7FM04_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_016566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR22592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="40537" checksum="111EFE7BC7CAE79B" modified="2025-10-08" version="1">MNTEIAEVHQCTEDIAALKLDVTQQEANDIFDNTKLQAKLDRWFEVRKKRLTASRMYESGCVINPNFPWPAASPDGIMLHDDVGYALIEISLNMVIWADITAPCDNKGQTGKKCCHGYSQVQGNLESENANAIKTILANEVEKFEPKLTGFSSDGSSVMTGKVGGVAALLRRDHPSMIRGRQIALLAEHFFPDDTEKAKLKVQWNGFKYHTHDILLPNMREEVRDGKARMTPTEWLLLQLLRSGGLRHFNPELINRLSGGMLKGLLHVGINGPEVDHSQPIIKKAVNTCLEKRPRRKIRNSKGKKQKCYSLCVNQCQCRDGSFTPCTEDIRAVLKEILVEEKFDGYSSDDDADNNSDCDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMN3</accession>
    <name>A0ABY7FMN3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR23485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="245" mass="27700" checksum="238CDDA6021CC9AD" modified="2025-10-08" version="1" fragment="single">MRDSYNVLLTSKISSTKLKTMETTILQVWKQSVQEYNTCNCLTLSMIGIPERVVDLQGSKYWQVKYFLLKSGTVVKSMTSSSLNLSLLQEKLTSSNIAVQLVKEKKTTYKLSTAFSVYLNRDFNVKAQSTSSVASKFTVSLSQTWGTKAIVTGFNVKPDISLSSSLQFVDLLSRTSVYRIYYLMWNNCDRTHCDPLDPDSLPTLTAKELQKQINFTSPSNTTYEVKDSTKAVDFSYHFSVSVTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMS6</accession>
    <name>A0ABY7FMS6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAT4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_016205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="186"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR22231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="269" mass="29662" checksum="C65B6566DAC5ED54" modified="2025-10-08" version="1">MRVFAALADKGTTCNLHVRANKNRNVEPVHCFHSQNNIYCKEPAHCFNAYHCINYKEPAHCFNGYGVAAEEDPCKGKPCSLTGECAISRLGKCTCKKGFKFEDETNTKCVDMDECGSHFHDPCEHRGICHNFVGGYRCICSEGWTHTAEKGVCDIDIDECKQSDACSDKGLCNNTDGFVGDNCTSDRDECTAGMSDRCSHRGHCFNTVGSFRCECLSGWNGTHCEHSTGEKTACMPGYSGQNCGGVLCKHGYAVERKFNETSPTNKTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPN4</accession>
    <name>A0ABY7FPN4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LRC40-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_037859</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="129"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR24190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="530" mass="58380" checksum="4DDAE382571A087C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQ75</accession>
    <name>A0ABY7FQ75_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HCPE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_036698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hcp beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040239">
        <property type="entry name" value="HcpB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13891">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13891:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR23029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="211" mass="24250" checksum="A29086A87225AF18" modified="2025-10-08" version="1">MIDPNTDAEVLEHYYKKFENNNKFNCFEKKDQEDFYLKNERIPEAKAAFKINCFENSYGPSCHRFANLLYDEGLVERDDFIKALQFGCNGKNFSSDACALLGMLHDPRPGQLFQKGVFLEDNMKKAVEYYEKGCNGGAPQGCHNLANMYNRQGNSEKALLFMEKTCELGDRKACIFVYNVYAGMSKHFPDIKPNKIKEEYYKKIVIDSSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FS83</accession>
    <name>A0ABY7FS83_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="68" mass="8107" checksum="2A23C5E3D5F8F7C4" modified="2025-10-08" version="1" fragment="single">AIKETNSNYEFSSELRRLICKEKHGVPTIWLQMFNTIESIDKRFMAFFGDTTRLYSLCRRLRCDHCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSB8</accession>
    <name>A0ABY7FSB8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BGH3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_037285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046880442" evidence="1">
        <location>
            <begin position="23"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="159"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="389"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="530"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR23616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="688" mass="76505" checksum="FEBD5BCB8E7781C1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTH1</accession>
    <name>A0ABY7FTH1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33658" checksum="B8CE5BA59AAA0531" modified="2025-10-08" version="1">MVKNTFGFAVAIFTACYADLHKNLQQSCDVEYGLDDFIDDEILVVYDGAQLSRTCKVTFEQEYSLENLCVEAERFNVADEHEDVTLEYHSRFYSPAVPDKIYTKYDTPIPDWCSSSSRIIISFDSSTTRRGDADIRLRVYKQDSGAENFADDMISAASPVVLVVAGVVGGVIILCIIISAVVALICYRRRRSRAGHVHSPATPSTVAHQPQHRPHFSGNHGQPQAGNPAQQSYWNQLQTSYPTDQPCGHQQQKTQPHQHSHSQPPDIVSRFGEAVRVALSWEFKQFVAMKEYLVAMKSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUK9</accession>
    <name>A0ABY7FUK9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TTC33-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_038416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052658">
        <property type="entry name" value="TPR-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15544">
        <property type="entry name" value="OSMOSIS RESPONSIVE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15544:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="204" mass="23101" checksum="8B8123C2E2F04D14" modified="2025-10-08" version="1" fragment="single">MNNGTSVKCFGWKRKVGANVSKSVSTAFEKESKPDTDPEIEEGDVDWLTLFPTKKRHVIRLEDGIGKANRLVQEGSALMELCEVFPAVQSAQKVIKLAPTWWIGHQTLGRAFLGMGEVRKELREDDLLWAVSLLWKRKKLEEDKIRQQEDLKKTSGVKITEIKQSDCESDVNEDTGDTVVDIYRGTGNKLETDTKVNENIKRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWK9</accession>
    <name>A0ABY7FWK9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GRAP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_010820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026204">
        <property type="entry name" value="GRIPAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18978">
        <property type="entry name" value="GRIP-1 ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18978:SF1">
        <property type="entry name" value="GRIP1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="596"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="238"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="338"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="482"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="744" mass="84512" checksum="AC5A04AF64801C3E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXI1</accession>
    <name>A0ABY7FXI1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CADN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_011558</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR25854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="268" mass="28805" checksum="6FC9BDBC04A5D4AF" modified="2025-10-08" version="1">MFIQLMVGGERGSPVRFVNATTKRTGDEHVTVRPQLVQGTEAGLTGSHGWLVLRPAGMAPGSGYSFVKIINLKTGADIVKAKGEKAKIVLISYVQLMETGLKGKDGVCVTNPATLDTNRETEPAQIPSQLTEGKTAAEMIKKRQHATHTIVQVRKNLNGNWGDWGHWSQCDVTCALGNQIRKRSCDNPLPAFGGQECAGKETELNKCQGGPCPIWSAWFNGPCAATCGQGTYLQVRHCSTGVAKDCGGQQDNSLSVNLHLALNNYVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FY70</accession>
    <name>A0ABY7FY70_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RSGI2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR27153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="936"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1188"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1386"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1770"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="960"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1188"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1207"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1386"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1406"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1770"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1790"/>
            <end position="1804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2278" mass="266560" checksum="4387026E323DF38F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYD8</accession>
    <name>A0ABY7FYD8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR27000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="197" mass="23605" checksum="8FBD0B0CF3D95D9C" modified="2025-10-08" version="1">MGSETETDEREKGGEKRERERKRAREREKKEGRGTERGWREREREREREREREREINREIRGLEEGESTSALVHQQRQQQTTQEQWQQETMQQHKKHMKAVSQKGESTSALGHQERQQQNEQQPRQPVTMQQKQKHMQGVSQKARDFHRATLWMDMSLWRVKFRLSAVSIESPYVYILYRLGIVVRAINSAAPRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZ49</accession>
    <name>A0ABY7FZ49_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Reelin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_011805</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Extracellular matrix serine protease secreted by pioneer neurons that plays a role in layering of neurons in the cerebral cortex and cerebellum by coordinating cell positioning during neurodevelopment. Regulates microtubule function in neurons and neuronal migration. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Oligomer of disulfide-linked homodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the reelin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034968">
        <property type="entry name" value="Reelin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049419">
        <property type="entry name" value="Reelin_subrepeat-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11841">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11841:SF1">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21471">
        <property type="entry name" value="Reelin_subrepeat-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR26101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="130" mass="14983" checksum="F0988B778698F07E" modified="2025-10-08" version="1">MNELVDDGDHLSVTQCRLSDSYCRKMKTISFIGKPSNDDERLLTTESMHIGTGYIMQFQFVMGCGLPYSETVDNRVYLEYSTDHGIHWNLVIEPCLPPAPCESVHQGTMYDWTQFREWTRITIALPVATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G045</accession>
    <name>A0ABY7G045_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Caveolin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_013532</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Caveola</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the caveolin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001612">
        <property type="entry name" value="Caveolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10844">
        <property type="entry name" value="CAVEOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10844:SF19">
        <property type="entry name" value="CAVEOLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01146">
        <property type="entry name" value="Caveolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR27828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="112" mass="12488" checksum="6BA324E25BE2E474" modified="2025-10-08" version="1">MADALDLINHVLGEPEGAHAIDCVWKLAYTCFNCWLGLCYKIATLLCGICIAAEWGCAFAEIAFYHVWFITPSLKYCELNCAVCTKLLKTCTQCCCEPCCEAFGALFIHFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0I6</accession>
    <name>A0ABY7G0I6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATR interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033349">
        <property type="entry name" value="ATRIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28594">
        <property type="entry name" value="ATR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28594:SF1">
        <property type="entry name" value="ATR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="739" mass="81978" checksum="4A7ADB6CDF8B1199" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G194</accession>
    <name>A0ABY7G194_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CXXC-type zinc finger protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_012776</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR27072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022056">
        <property type="entry name" value="CpG-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12269">
        <property type="entry name" value="CpG_bind_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="34"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="169"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR27072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="393" mass="46194" checksum="EEA8305369822957" modified="2025-10-08" version="1">MTKKTINDQFSLPERKAKVNQLVKTIENVDDPDTRYCICRSTDGTRFMIACDNCEEWYHGDCIGITETDANDIKQYYCGRCRAKDPSLKTRYKHKKKSHQHKGDHSHRYRQEVDEVEELQDDMPHQCLGPSCMNHTRQGSNRIYELLPPKIQQWQSSPCVAEERNRRTLDKIRREQMEARQRLMELDMKHKELDALVENAKNVKAESDNEQASETEDDTEYNLFCVTCGHEISQKTALKHLEKCFAKFEAQTSFGSIYKTRIEGSSMFCDFYNSQSRTYCKRLKVLCPEHTKEPRVSAEEVCGCPLVTDVFEESEEICRTAKRRCNKHHCWEKCRRAQVDMERVRQWMKIDELFEQERNVRFALSNRMGVLGLMLHQTVDHNPLYPISVPDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6W0</accession>
    <name>A0ABY7G6W0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HELZ-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_003713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027897">
        <property type="entry name" value="DUF4559"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF365">
        <property type="entry name" value="HELICASE WITH ZINC FINGER DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15112">
        <property type="entry name" value="DUF4559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="857"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="857"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1974"/>
            <end position="2019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2159"/>
            <end position="2184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2202"/>
            <end position="2229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2284"/>
            <end position="2306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2331"/>
            <end position="2365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2383"/>
            <end position="2409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2482"/>
            <end position="2527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1974"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2206"/>
            <end position="2220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2297"/>
            <end position="2306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2387"/>
            <end position="2409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2494"/>
            <end position="2507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR30145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2654" mass="300103" checksum="8684D17AE14BBB5E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G823</accession>
    <name>A0ABY7G823_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_033110</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="271"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="448"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="836"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR30568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="857" mass="98404" checksum="7F97BFFE309A5BDF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GA25</accession>
    <name>A0ABY7GA25_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">STOM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_033800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="2">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR31258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="225" mass="25247" checksum="76F2D7783A940714" modified="2025-10-08" version="1">MHKTSSRIQHKPLNDIEGFDESTHYGVVQEYERAVIFRLGRIKGRRAQGPGLFFLMPCVDTFIKVDLRTFTFNIPPQENTLDNATHYWGVKVERVEIKDVRLPIQMQRAMAAEAEAGRMARAKVISAEGEMKAARSIKQAADVLQESPASIQLRYLQTLHSISEEQNHTIVFPLPASLFQNAQTALPRLLGAGMQEQKIVQGTKGTESAEQPLVTVMDTEVNTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GB53</accession>
    <name>A0ABY7GB53_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SC5A6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_033892</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR31350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="157" mass="17466" checksum="B7B0EFE8D62C02F2" modified="2025-10-08" version="1">MTEDMKFKPWDWVVFAAMLAVSMVIGIFYAVRETLGKTEATTGEYLMGGRKLGLLPVSISILVSFFSAIVILGNPAEMYTTGTMMFMLTIGMLLSIFLAATIFVPLLYPLQLTSSFEYLELRFNSKVAKLTGTFIMIVQQGGMKAVIWTDVFQCVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GCM9</accession>
    <name>A0ABY7GCM9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_033631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="107" mass="12126" checksum="32891EA94A735FA6" modified="2025-10-08" version="1" fragment="single">MNQFYARCRGISTVNRFLSLKTSLTGETTVIGTISIYRPHDSDWFLKVSPTRTSDADAASITGYQSRDVYLRVCEGTTRVKMWCNVTAYRSPPYVGTSSRSRMRRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GFH3</accession>
    <name>A0ABY7GFH3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="417"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="502" mass="56369" checksum="5393EE241031F954" modified="2025-10-08" version="1">MYSSQLPLFRQLMMSSLEAQSPMMSQRAFDVDEGDSLSSNEGSPTTFQWVDGRLVGHKPLNRQADEPRSPEQLKKAFENIRMAVPPSPPPSADCRSMVDASTETISEALISGRVQLHEVKDIEKGLKSTATKVCDISQITSGSSVSTNQASYRNGNGSLKVNGDFMFNTNVSEAASTAADLINISKKTGAKITVGVQPDVKLDCDSSTSKLGYLTIKPLEQKTKVSDTLTPSVDYNSQAISSKYENQQTIKHQELRDQMINATNERADLESDSPVGNSKLEISMEEIPLNNSECSVPKQYNPAGNSNLYGSKEEVPAENAIHETDKSILVFSKVESRANLMKEIEQVKNNLIDPFQPKPSDTFGNMNLKSKHFIETEYTQTTNDVKIDLPNDKSVQDNTNLKRKCDSEIDIQPKKRKLSQEEELKKWELKKTKAEVERLSLENTLLRQRLVEEQELFKLKKKTEEMLLDQKMKMLQAKTEYYRKGCPDDVKKKYLNNGDCEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GG07</accession>
    <name>A0ABY7GG07_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NS1BB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_034388</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd18306">
        <property type="entry name" value="BTB_POZ_NS1BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF26">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="46"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="632"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="646"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR31846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="693" mass="77155" checksum="DAD338F20CAE9726" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D8P2</accession>
    <name>A0ABY7D8P2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">M3K1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_006513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="265"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ94042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="529" mass="58504" checksum="8A4A27E29BD318FB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D9D4</accession>
    <name>A0ABY7D9D4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052787">
        <property type="entry name" value="MAVS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21446">
        <property type="entry name" value="DUF3504 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21446:SF6">
        <property type="entry name" value="MITOCHONDRIAL ANTIVIRAL-SIGNALING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="238" mass="27289" checksum="1DFCEE2240E7D903" modified="2025-10-08" version="1">MVELCMYFCRRGQENQRDLTVDMFHIMADETDDREYVAQRVSEVTKSHQGTSKEILGKDVRISFKLYINKKNPECSAFFQTPRDSFLSSDVVWFENKYVGKTYLGKMMFEFSESANLSREYTNHCIRATAITALSHAGFEARHIMTISGHRNESSVRSSVKDTTPQQKRVMSETLSNILPHSICSVFDDGMNDALCLSASQTERILEDITHYENFSGACASNAETNKRNEIETLRRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAB5</accession>
    <name>A0ABY7DAB5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="99" mass="11686" checksum="2B316F37F34C3383" modified="2025-10-08" version="1">MNSGYYKRKTIKHTWYPPVSSHPHITFDAWRPGHTNKTHMTKLPRRASKTMFAIYTSPAYVTDNPRDSVVSRETLLTYLTREAEKISSYQTYDVHKKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCH8</accession>
    <name>A0ABY7DCH8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CERS5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_007469</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="38"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ94998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="233" mass="26000" checksum="15C72629057FC198" modified="2025-10-08" version="1">MSRRKHRRHRGSVLLTKTEAISQLFPELLIIPLGYKLGIKKKKLVYVNAIPSLEEVYKTKKKPDDKQCMGLSKQLDMPLRQVQVWFRNKRNNDLTPPIKKFCDNASHGYGEQKTAGPTGQSRLIYSTAIEIFHFIDEPFFVYYFVNVFLLILQVLSLLWSWSIGKIIYNTLFAGGAEDIRSDTEEGDSLSSNGDLTQNGTTNGVDGSVTSADTIGHVNGANATSKVSNNGVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCU5</accession>
    <name>A0ABY7DCU5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DIAC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_007001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051887">
        <property type="entry name" value="GH18_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46290">
        <property type="entry name" value="DI-N-ACETYLCHITOBIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46290:SF1">
        <property type="entry name" value="DI-N-ACETYLCHITOBIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="4">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ94530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="230" mass="25900" checksum="5930D382D1932251" modified="2025-10-08" version="1" fragment="single">VSVDVAWGAQGVDERSYDNQGLAAAADFLFIMAYDMQSQIRGPCVAGPNSPFPRVMEGVQSYLNASISPDRLVLGLPWYGYNYSCLALSKENECSIRAIPFRGVYCSDAAGNEINFNTISSLLESSTSGRLWDEESQTPYFNYRMNGRSLQVRYDDPKSLKVKYQYAIDAGLRGVGVWNTEALAYSSQQPRDIWDVHEMWTTLPDFRQNQRQLNNRKHLPRPDGSDTVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DD32</accession>
    <name>A0ABY7DD32_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XYNB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35684:SF3">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="602"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="937"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1440" mass="145205" checksum="6EE4B0FB39D00F02" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DE30</accession>
    <name>A0ABY7DE30_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="131" mass="14796" checksum="85A8613D42407F1C" modified="2025-10-08" version="1">MSELNHNSSLAVCYPTHRFLRAMKQQIVARISMDRAPDLDNLQDGEIIERYRIDRNGIDFLVALLGQSIQPKALRNKALITKLLTTGPIQLNDADIHGVSLSTVSRVLFQVIAALSSPELIRRNIRLPRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DE57</accession>
    <name>A0ABY7DE57_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="286" mass="32144" checksum="25B2CC85A18E0414" modified="2025-10-08" version="1">MGEEKGIGQGKNMEDRQGNWMVKKKIVREETKWGGERKMGGFKNSTRGNSDYLSQLIRAFGFPFQLPIKKMTQSRPIMANEIKKLMKETKVIEVKDFIKVSDKHNDATATETEAARRPIMSRGKPMTAFAPRTKSLPVGKSRPIVSQELESQLEQGKLFLDLLERKGHDIDKLETVFVENRLQKALTIIGSCKGVADKQDVELTKPHHPPADAPAQEWNWKLPSIVHVLLIMCLSVFCLVGLWSIVKACVYDGGYTQGPITTHICTHVYIHIGQHASNGSQYSNCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGA7</accession>
    <name>A0ABY7DGA7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TMP2L-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_029387</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF12">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1134"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1216"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1240"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1344"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM SLOG" evidence="11">
        <location>
            <begin position="372"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="12">
        <location>
            <begin position="744"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="147"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="222"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1460"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="237"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAQ96697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1603" mass="183332" checksum="779847C8E0E221B9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHL4</accession>
    <name>A0ABY7DHL4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_029494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ96804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="139" mass="16597" checksum="C9944E4C8348D8C1" modified="2025-10-08" version="1">MKKHLKSRMTIIFSQSEYFILVVKNCSNSAKQQNIVLIFVWQIVILVEDCTCFVILDSFNKKLESTNHKGKVWGKWKNHDDQRNVYGGKENTSLVTQIVFLHHKIYHNDYTTSFTTTVWPVKSEFVYQYFTNDMTRWYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIA4</accession>
    <name>A0ABY7DIA4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COLL6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="584" mass="63817" checksum="3C9D4BE31A4C20E7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIF4</accession>
    <name>A0ABY7DIF4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KATIP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_030107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026704">
        <property type="entry name" value="KATNIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027859">
        <property type="entry name" value="KATNIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21534">
        <property type="entry name" value="KATANIN-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21534:SF0">
        <property type="entry name" value="KATANIN-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14652">
        <property type="entry name" value="DUF4457"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KATNIP" evidence="2">
        <location>
            <begin position="761"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="KATNIP" evidence="2">
        <location>
            <begin position="915"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="KATNIP" evidence="2">
        <location>
            <begin position="1053"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1219"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1219"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1230"/>
            <end position="1243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1266" mass="142055" checksum="13F0969CEC80403A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DL51</accession>
    <name>A0ABY7DL51_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_022452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ98079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="276" mass="31231" checksum="DD644031BC7EF11D" modified="2025-10-08" version="1">MSESTPKSTVKKRHYCCICSNYREKVVNELCVTLHRFPTDDKLRKLWIKRLKTVSPNFVSNLKNDRLSSVHFANGKYTKENPVPCVFIINNKEKIFKLSKVESSEPAYKCNEEGQEAENVEYIGPDCTLTTSSVSEYASIKFHDYAGQIEFTVQKTLNKDTQADKVGVSFSTQTEGTSSVSVTKCSVSTQTYFETPLCKCMSKTTSEVGVQVNKPDLTVEDIKSNVMCMFYTGLPNVETFHLLFDEMDDVESHTNRCGNGENKGRPRALRLIDDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DM88</accession>
    <name>A0ABY7DM88_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="59947" checksum="A157209D9F5699F9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPB7</accession>
    <name>A0ABY7DPB7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MEG10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="112" mass="12118" checksum="643B20151E056B03" modified="2025-10-08" version="1" fragment="single">MKNKTALLKQFVNFYTACGDGHFGMECSEICGNCLSNDQHCDHINGHCTNGCASGFKGPVCKQTCPFGKYGDQCNSHCSGHCLNNNTCHHISGHCTNGCNAGYNRTDLFCNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRQ9</accession>
    <name>A0ABY7DRQ9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GLYR1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_024760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="2">
        <location>
            <begin position="217"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR00388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="249" mass="27473" checksum="FD02EF4498475E1C" modified="2025-10-08" version="1" fragment="single">AWIPFETVYPYIGNKEKFLLTTRIPRGFKEAIDAIEDAIKNMPEEDRVKAEELPSIDEELAQIFSDTADSEVSFKAMADYQQRMSRPDPVPEELNNSVESADSDSPDKPKRKKRSRESDRGKVRPVKSLTPSEKILKRAKMTASSSPSQNIFSSFSAKKSPGKIRERKLPELRVSESDLSYDPSLGAPGMPLSSGSLASEAGGTPSQVKSVIPTPMRIGFLGLGIMGQGMVMNLLRSGHEVTVWNRTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSE1</accession>
    <name>A0ABY7DSE1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023605</name>
        <name evidence="2" type="ORF">MAR_023638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="67" mass="7371" checksum="8BD68A7850C4E83B" modified="2025-10-08" version="1">MSCQSEEKVGWGKKAARPVGILISPWGATSDDYYYKCAAPCPNTRIGDVISLDVLAAGRIWMPRIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DU82</accession>
    <name>A0ABY7DU82_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KCTD7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_007840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057890">
        <property type="entry name" value="KCTD7/14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF145">
        <property type="entry name" value="POTASSIUM CHANNEL REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25611">
        <property type="entry name" value="KCTD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="2">
        <location>
            <begin position="80"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="KCTD7/14 C-terminal" evidence="3">
        <location>
            <begin position="178"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR01282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="298" mass="33775" checksum="A788C9BB4403FA85" modified="2025-10-08" version="1">MSDSETSDSSVEEIEIKPVRPVPRSRPKQNSKDKARSPARSLSPTSVLNGEGTVAKKVLDNYTVTSSINTKIEPFPNVIPLNVGGVKYMTRLSTLKKFPDSMLAALFSGRYTVDKDADGNYFLDSNGILFGYLLEFLRNGFVPPREHAVPLYREASYYGLHELAEKLNLMPAVVSLIVKESHKSQFPNYEEIKEEVIRVAMENATFTKMGEVFMYVFKSEFIPKTNTFNPNHGCIIESAQVKCGPWDGPVDEEVFVKCLESDLIDDGFDVKPHEPKKKCRYYHGQSCQKFVYRLQIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUE8</accession>
    <name>A0ABY7DUE8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="217" mass="24817" checksum="29F64F76EEB49F84" modified="2025-10-08" version="1">MTSSTPIQLDREFTLSQINDTALLRQAEMERKQPNLSLNDYTFLSQWKRTLTDIDMKRRKADMRERDRMQFRIIDKITSPTLSFELENFKLFGKLNKTETHIHNTIPTTETVAAEKDYIEFDKMRKSQPQAVTYTSFYKNIQGEVKKPKTPKTPSAIAFSGIEKQTSSEESRGQSRAALRNSSQAISSSTPSHILSGTFSSASVVKQSTPIFSYRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUJ6</accession>
    <name>A0ABY7DUJ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="204" mass="22714" checksum="3E7BA00ABE77E2D7" modified="2025-10-08" version="1">MYSRLKGNSLKNKKTNYDESKNVPFGFPSTSSPLAGTLNTVVQREYQTLPQLSGMCKRGQYSSYSPDMKNSMARYAIESGNSKAAKHFSAKQGRSVNESTIRSFKSSYLLRKKTEGVDQVMELPVGKRGRPTILPRALEYKVHNAGGEVNTSIVLGIGLGVVKTQDKYLLKQNDGSIELCRIWARSLMERLHFAKRDNGSVALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWK8</accession>
    <name>A0ABY7DWK8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TCuncharacterized</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="197" mass="22881" checksum="2C00FAC49E962AB5" modified="2025-10-08" version="1">MKEDTERGTNTTRQEDTERGTNTTMQEDTERGTNTTRQEDTERGTNTTRKEDTERSTNTTRQEDTEQGTNITRQEESERGTSTTRQEDTERGTNTTMQEDTERCTNTTREEDTKRGTKTTRQEDTERRTNTTRQEDTERGTNTTRQEDTELGTNTTRQEDTERGTNTTRQEDTERGTNTTMQEDTERGTNTTRQEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXV1</accession>
    <name>A0ABY7DXV1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="233" mass="26602" checksum="37B49968E4C2D9DB" modified="2025-10-08" version="1">MDTTVRQYAHHVQETVLLAKLSTGDLISQEAKYHLKCYRELYHKTRVTDSDVDQGQTESRVHGIVLSGLIAYIEESHRDVADVQIFKLSDLAQLYCEQILSNIPDLEAHKHGKEINLMFKVDSGRLVQKAKDFDDEAVILSRAANIVRQDVFDQDVDTFEGTFNEFCQDRCVPQSLKSLVGMILGGPNIKFQFGKFVEAQAIKNSSKVYHLKQYETPLPTYIGMLIHVQTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXX5</accession>
    <name>A0ABY7DXX5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_008898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046526352" evidence="2">
        <location>
            <begin position="24"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR02340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="739" mass="80922" checksum="DF7C2673DD32CE8A" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZ76</accession>
    <name>A0ABY7DZ76_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018792">
        <property type="entry name" value="NUPR1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10195">
        <property type="entry name" value="Phospho_p8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="64" mass="7373" checksum="93F29D2C54B3342A" modified="2025-10-08" version="1">MSDKAKDADKEYMDKYDDYNIEQDKYVGSSHSGKGRSKKEASQNHHEDPSGHTRKNVNADDFHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZE3</accession>
    <name>A0ABY7DZE3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CA050-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_008535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019534">
        <property type="entry name" value="DUF2452"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14553:SF1">
        <property type="entry name" value="SIMILAR TO CHROMOSOME 1 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14553">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN C1ORF50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10504">
        <property type="entry name" value="DUF2452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="123" mass="14112" checksum="714A6769C0F5FD8D" modified="2025-10-08" version="1" fragment="single">MADEFTKATCGSKLMVIADQIRYLQEQAKKVLEEAKRDAMMHHAACNLVKKPGQIYYLYEPFKLEHDMSWTPYDKIEQRSQDFAFINKVMNAQHALVDAEAPNFKGLTLESRNSSSVKLTDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0Z3</accession>
    <name>A0ABY7E0Z3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_009174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="255"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR02616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="339" mass="37252" checksum="510A5589F5800074" modified="2025-10-08" version="1">MSTGICSFCSFLEVTCFIGVMGDIGLIAGATLCCSAAATRSNFGGIIEFSFFAVSFFAEVGFAKVGFAEVGFADEVGSADEVGSAEVCFADEVGSAEVCFADEVGFADEVGFADTERQKTAEMAKGVYSLSFLMDGSTDISGNKQEAGFFRVAEYGLWGHLSSMSHTNLKADNLYKIMVDKSFVCYALSIKEFVVSIFQLELPHCFSTRRSSIDEVCKLLHMGLATSEMWKTVHFNNGLLLRKVTSQDNGYILGDSRYNEALVRTRVTVERSFGVLKRRFPCLSYGLRLEPEMACQVIIACVFLYNYGIERRDIMANMHDATDIDQPQADVIPANENRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2D4</accession>
    <name>A0ABY7E2D4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FLP06-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046919586" evidence="1">
        <location>
            <begin position="39"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="457" mass="52075" checksum="83643EBD4B091B36" modified="2025-10-08" version="1">MVHYHDSVPIIPENMGEQWLLQMILVMLTADLCTLVSAEDSHNMDFTQLAYGIPDKRLSKFVRIGRGLSSFIRIGRNKPSENIYQGLDDGDDDFGDSDDVTDYSAFSDVIPDDYRQQDKRMSSFVRIGKNFESDEPDIYEEPEKRAGAFIRMGKFPSSAFLHRNGGRINSISRQPYYRRTGRIGHSSFIRIGKRDTTEALRKAEFENQNEISNVGDDQGKPSYYDGQQIVNDGNEQRRYIRLGKDLDGDEHGNRYDYIPMGDLPDKRMSSFVRIGREPGQMYENTDLNPFGMSKRPNSFVRIGKALEQLRNTIKKRMSSFVRIGRNPLDLMLDQDGSNNIGADSTKRSSAFVRIGKQGDALEADKRMSSFVRIGKDTRSLDYNNEQKRYGYEPPFKRMSSFVRIGKNVDGFQQVKRPSAFVRIGKTVLDDNTPVVDENKNDVFVAVKGETGTTEQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3N8</accession>
    <name>A0ABY7E3N8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="81" mass="9061" checksum="818976F3DFC268AB" modified="2025-10-08" version="1">MDYIHVVLYVPTGEAFFQDKPSKGIFAKKGDTNVTAAVSMDRKPVNTLSSLSDQGDIRAHIRIMGREVMDLHQPHNMAAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4N6</accession>
    <name>A0ABY7E4N6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BUP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_010316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF2">
        <property type="entry name" value="BETA-UREIDOPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR03758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="441" mass="49989" checksum="2159EB0D32E24AC3" modified="2025-10-08" version="1">MSAEFQSVEKSLEKHLPENELAEVRRILYGKELKQLDLAGDALAEADSGDFELVGYQFDALEEETRPPRVIESLHKRISDIISTGAKCGVNVMCMQEAWTMPFAFCTREKHPWCQFAESAEDGPTTRLLQELAKKYNMVIISPILERDENHGDVLANTAVVISNTGAYLGKSRKNHIPRVGDFNESTYYMEGDTGHRVFQTQFGRIGINICYGRHHPPNWMMYGVNGAEIVFNPSATVGALSEPMWPIEARNAAIANSYYTCAINRVGTEVFKNEFTSADGKPAHKDFGHFYGSSYVAAPDGSRTPGLSRTRDGLIVAEMDLNLCRQIKDRWGFRMTQRLDMYARELTEAVKPDYVPDIKQFYGGVCMKIRKKRLQKHIPLLHKFTFAVFLQPNLVPMKRISFPPSAIAVSKFLRHETENNFDKSFKQFDSNNYEAIVSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E594</accession>
    <name>A0ABY7E594_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22018" checksum="1E0721511608A5F3" modified="2025-10-08" version="1">MNTLAPHFNMRGIAGFGNVTGYFQVPAVLGRSRLTGEALYTGKETSQVLLLTYMRSGSSLTGDILQHSPGAFYIYEPFRSLGHKNKSSYILNYANVVDYWDNVTSLLLLTYMRSGSSLAGDILQQAQESFYLYEPLHSVEKALVEFKHLSMATPDKSHRLPPLEFNSEAAEELYNWFTCDIPKLPNIALLDSFMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7N0</accession>
    <name>A0ABY7E7N0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CCD13-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_021367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038929">
        <property type="entry name" value="CCDC13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31935">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31935:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="242"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="576"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR05998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="636" mass="72289" checksum="B3188C86168EC7EE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8P7</accession>
    <name>A0ABY7E8P7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ACHA6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_020143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046329930" evidence="6">
        <location>
            <begin position="23"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="7">
        <location>
            <begin position="80"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="8">
        <location>
            <begin position="170"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR04774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="344" mass="38633" checksum="0743BBF6FA194BE8" modified="2025-10-08" version="1">MKTRILFHACLLAIGFTALVEAQTADDVKALQSKLLDGYNKNVKPVFNQTDVIEPQDDIWRPDAALQNAFKKFKALGSSYLKILESTCDVDITYFPFDVQECPIKITAWSFSENDVKILKEKDQIGQREYEENAMWTLIGSSVEQEKTGDSSIIFKIKMKGKPSHFVINIIIPLLLLSFLAILTFVLPISSGERASYAVTIFLSIAVFLTIVSSELPSSSDNVPILSIFLAILCVDTTAIVVVSLFQLRLLTRDEIDQPVGGCFKVIYNITMAIRCKMGGRKRKHSFNIESKGVDVKANSISWKEVVNALDYLLFWFFLLFTVAVTTYYFVVCTTNLPAEQNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9N5</accession>
    <name>A0ABY7E9N5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="99" mass="11097" checksum="CA5DF9F0BA56D71C" modified="2025-10-08" version="1" fragment="single">SVTGEKHLAVAVTLLVVQICVVLGVFVVLHWIRTRPRGMNFVLWRPWVVIHVGGVIDLVVVCVCGGYHVNINTEKRFINNYFSVVGNKGQIKDGSDRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECX0</accession>
    <name>A0ABY7ECX0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LPLT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_017668</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45692:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45692">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GAIN-B" evidence="8">
        <location>
            <begin position="493"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR07710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="721" mass="80772" checksum="B373B5BD1C6B816C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDI6</accession>
    <name>A0ABY7EDI6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="286" mass="32359" checksum="DBD8B8AA83AA7136" modified="2025-10-08" version="1">MFLPVTKRKDKERQAGEMAITGVYIAMSVVLCLAVAQEPNPKGDQTALLTKLDALEARLQETDNTLQSLQNKYNRRATLTKPYPNPHGEDPLTVPYLERDGWEMVFRASAGNGQTVYDAWTKGTGTSTTKPLDMARSYTTHFREANLEQSWTSLKIKHVKFALYKDNIETAYIIFNGVGSTITSWFDKTKILESSWSDLTPSATFNFFSVIGADDGRVLRRFFINQKYAGCAGDVGHFAVVEEKGVCAMDKHVRYPQFVYSDMNSADVWERSQFERADYLAIYVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDJ6</accession>
    <name>A0ABY7EDJ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_020600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR05231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="286" mass="30768" checksum="D7DCEA2EF4E79715" modified="2025-10-08" version="1">MDVRVTETVFHQEVWCSESSIKRIIASGLCLATTLLYLFGVFLPFWSVYTYVENGVQIGHYGGLWNYCLRDSDLGTRCTTFSESSLEPWFRTARGLELLAFMGALALLGLVIAYMFFLRELKYGFIQWIVIGLCFGIALFSLIGMIVYGACETDSSRLSSSYGLTFCAFLGASIAGAVFLWDKIDQMKGTDASKMSFRGVSSIPGSRGYNGRMLSSRSRPGSRSGISQVTGNSLGLPFRGGLSRSSTIASPEVAPAVAPAGAPAGAAAAPFSAVAGSCQSLNVRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EE18</accession>
    <name>A0ABY7EE18_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="299" mass="34935" checksum="E69AF72E2C058871" modified="2025-10-08" version="1">MHLLATIMSVVKARPIQSKTGPRKKVLPKIVQLGHQLPVKRPDELDVWTPVDVSGEIMSSECSHSYRASDGADKHRCPKFKNLFEYNIQHGDKYQIGRRLWKIPSIGNNFMPFHDKHSKSSEKDEIAMYRPKFQRWYNRLVHENTVILPPIETSERVKDNVFESNNFNEKKYVLKRNKNTGPRERFVRDEMYLPDAYSTCFTCKECHKQYASDAYVQTWAKRNQLSPTCTTTTTSSINGASTYRRNGRSIENRGQHCDVLGERYCQACVEWRNKMFSLQVEDKLANSNDLKKVHYSTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEK1</accession>
    <name>A0ABY7EEK1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_016802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="77"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR06844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="276" mass="30251" checksum="AAA71B474539140D" modified="2025-10-08" version="1">MEEQTNEPNEEQGTERVSRARELDEHNGQVKIVVHGVEAGEPGCEDSTAQRTDCTGSKKHCVVYKLCDKQEELVDAWTELFKEYIEADKVEVYQGDIFYEGPAADAIVSPANSFGDMDGGIDLDRLQKKIREEFNGELLVGQATILPTMEDLSIVDWSKYNCGEPIKYLISAPTMRVPETIAETVNPYLAFRAVILAVDEFNKTASEPIRSVLCPGLGTAVGKMPQDRCAYQYGENGEEKNDPPKSDTKLTDPTKPPPTEPGTTGAAGDDDASTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFV3</accession>
    <name>A0ABY7EFV3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IstB-like ATP-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15638" checksum="76678558A82329F8" modified="2025-10-08" version="1">MFSHSQMQRKMFDFTMVWSIDLKNGMSPLPFYIFLSGGAGVGKSHLIHAIYQGVSRVLRLPGQNPVKDRQKNDIQCRKPGAEKLNTLRSTYANLRLIIADEISIILAVGDLLQLNPVGDKPIFKPISHGYEALAGSLWTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHW6</accession>
    <name>A0ABY7EHW6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SNED1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_018495</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="31"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="125"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="163"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR08537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="225" mass="23874" checksum="83899EDFD1B2F1F7" modified="2025-10-08" version="1">MLIMTDATTTLDKIVYLLLGYDLQESDYYIEALSAPNNGAVSYTSTIQDSVATYSCLAGFQIDGVTSRTCSAVTPKGWSGVAPSCIADIDECNNTICGQGVCTDLVNDFSCACNPGYMGTDCSTEIDECSSLPCVNGGTCVDLVNQFKCNCTAGYTGIHCADDANHCDSNRCQNNAICENTANGYFCLCAEGYFGKYCQTRSKHTAFVSTEMAIAIGIGVVSSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJM1</accession>
    <name>A0ABY7EJM1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_035268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046211609" evidence="2">
        <location>
            <begin position="25"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR10192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="554" mass="63091" checksum="C5085F44D321DD43" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJS5</accession>
    <name>A0ABY7EJS5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="397" mass="45001" checksum="9C37157F9F4784F4" modified="2025-10-08" version="1">MNIVGAQSISELPVGHRYILADLGGGTVDICAHEILPKAELKELWHVSGGAFGGERVDFEFEQYLIKIFGGPVWSEFKCEYPSCYLEMIEEFETAKTRFDGKRESKLKIQKAFTETIKTHGEESFEDSIAAFKTEVQYDKNNQILVIGANKMKALFHHSVKGILETIEQVLQKSSAVESLLLVGGYAESQYVREEIKNAFSHHVKIVLEQSPQLAVMKGAVKMGYTPKNIIARKSKFTFGFASTKPFNPRFHNSDLMVTRNGKSFCDDVFEVLIEVGQELVYNASFPSTSREYLGTELKGQDIFFTIYRSTERKPEYCIESETCQKVGELRMKSPAGGWPKSVKFNRNITVDRISEFADKDVDAEQYDPLVYAMIRLRQKHMISLLNGESGTKYTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELQ5</accession>
    <name>A0ABY7ELQ5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">exodeoxyribonuclease III</fullName>
            <ecNumber evidence="4">3.1.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_035831</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="4"/>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF26">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="241"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR10755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="906" mass="102464" checksum="FC2D7FD935CB8257" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERM7</accession>
    <name>A0ABY7ERM7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CFA20-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="191" mass="22519" checksum="9F623A0A65EFE364" modified="2025-10-08" version="1">MFKNTFQSGFLSILYSIGSKPLQIWDKKVRNGHIKRITDNDIQSLVLEIVGTNVSTTYITCPADPKKTLGIKLPFLVMIIKNLKKYFTFEVQVLDDKNVRRRFRASNYQSTTRVKPFICTMPMRLDDGWNQIQFNLSDFTRRAYGTNYIETLRVQIHANCRIRRVYFSDRLYSEDELPAEFKLYLPVQNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETB2</accession>
    <name>A0ABY7ETB2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CLVS2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF130">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="108"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="333" mass="38832" checksum="14738E26FADAAC82" modified="2025-10-08" version="1">MLPAHCNINNVTMRGDVDFVSKLDEASKKKAKEELNEINDKDREMAVQAFREWILQQKWLRTPTDFAFLLRFLRARKFSQLGARQTIENYWRVKTKSPTWFKDVDPTEKKIVEIMKTGFYVIPKTTDKYGRRVIVERLGNLDMNKVKKKWGVENIFRTICLICDWVNRDENVQVNGIIVFIDNTDVTMGHFMNMMGTENGKKIMEFYQNSLPARMKGLHMYNEPTFFDAVYALFSPLMKQKTKDRMHMHGRSLTKVYEELGMECFPDEYLPDDYKGPSAGSTQQLVDTMISEIQSPDFTSYIKNLSSDKYGVDIAKLKENDAPVASFRKLNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETQ6</accession>
    <name>A0ABY7ETQ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="105" mass="12049" checksum="AA1D686789E06624" modified="2025-10-08" version="1">MDSKKVSEGASTAGRKEDLILRLEAYDRNLDFKGEPILLLEPLDTDWPESGFHQLQLEHRILLPKLSRPQIDGYFKYREATDKNITSDIKRDSCCTTVKELEPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EU46</accession>
    <name>A0ABY7EU46_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="94" mass="10794" checksum="A97025C9CB201323" modified="2025-10-08" version="1">MCGKMTAEQPQFKYWFVEFSELPRAMVITWVFSFDHINDARWLSMHIRDKDSLSEMNPAIYEELVAGKLIANNTNCPLSAVTLNQAQANANVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWM5</accession>
    <name>A0ABY7EWM5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Iodothyronine deiodinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the iodothyronine deiodinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000643">
        <property type="entry name" value="Iodothyronine_deiodinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11781">
        <property type="entry name" value="IODOTHYRONINE DEIODINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11781:SF22">
        <property type="entry name" value="TYPE I IODOTHYRONINE DEIODINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00837">
        <property type="entry name" value="T4_deiodinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="1" id="KW-0893">Thyroid hormones biosynthesis</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR12829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="258" mass="29631" checksum="29A9D1756D72D174" modified="2025-10-08" version="1">MAKLAQFNQLVDDFAHEIDFVTIYIKEAHPLNGWNLIGNKHYIRQHETIQDRIKAAKLLSDSGCPLYVDTIRCPLYVDTMDNDAQIAFSSFPESLFVLEKGKIAFKALGPFAYDPCKLRSWINGKRVKSNKLDRFTAEMFWILRQIKILILTLLIGTARFLLLASMDTLIIPVCKRLPEKWKPKRLAKTALNKTYKTNVSYKTFLQCLRVVYQRQKCNISVGMTAPNAKVVSLDKKLHNILDFRRSGRLLVVNFGSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWS5</accession>
    <name>A0ABY7EWS5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SYG2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_027456</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="53"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="146"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="354"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR13276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="529" mass="58400" checksum="5028EAA3F9F5D6F2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EYI9</accession>
    <name>A0ABY7EYI9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="71" mass="8008" checksum="1597CC6DA54994D6" modified="2025-10-08" version="1" fragment="single">MQLIRLKNGSHIVVQQGINLCGSAFITTQSPFYYIYCCDGVVPQFEKSKWNTMECCGTKTSQTCCNNTIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZ61</accession>
    <name>A0ABY7EZ61_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_005307</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14294">
        <property type="entry name" value="UBA1_UBP5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF10">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="15">
        <location>
            <begin position="164"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="14">
        <location>
            <begin position="315"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="13">
        <location>
            <begin position="584"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="13">
        <location>
            <begin position="647"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR15202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="742" mass="83005" checksum="6812F95FFCF79924" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZA6</accession>
    <name>A0ABY7EZA6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_004534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="6">
        <location>
            <begin position="456"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="5">
        <location>
            <begin position="757"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="4">
        <location>
            <begin position="1313"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="1807"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="600"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1118"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="600"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1118"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR14429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2018" mass="229885" checksum="7F2D8787B84FFF7C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0A1</accession>
    <name>A0ABY7F0A1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="200" mass="22423" checksum="1228D7611C2FBC65" modified="2025-10-08" version="1">MRAIVPGSLAPEHVCTDVKAISKVFEKSACEHIGYVRMLSWFVSITNGTCTLVDELLHCVAKSMYGLREHENIESCVLHMRDALRDTHVSSMFPAYPFKWKFCEVVWCENFHKFTDAQVACFVRCLLGPAAICIGGVLAFLCLVTAVGRISNNSFIAWCIKALLVMIVAVIWIGYKPKLFTLFSVVNILKFVIDCDCCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1C1</accession>
    <name>A0ABY7F1C1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_005482</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF28">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045858549" evidence="3">
        <location>
            <begin position="25"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR15377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="104" mass="11132" checksum="93B9F78153284073" modified="2025-10-08" version="1">MNTLVKSVVAVAFVLMLSARTAYGIECYSCVAGDTKCKDEFNADAVARGCSTTYKGFDGCVENKDEKQALCFCKNDKCNNASGLTVTMATIASALLLSHLLKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1H0</accession>
    <name>A0ABY7F1H0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_005016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="48"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR14911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="358" mass="40376" checksum="57574252C5C02135" modified="2025-10-08" version="1">MMVPNNTTEPDIFLFKSGYEFPVYGLATGMFYYIHIPAIVCLIASVICALATIVLSFKDRKVGEFFTEWSKGERLVVYISTCDGLFSASNLMNHLQVLFTLAHVRPKELCVFYGFVMTLFVVAQILIVNLVAINLFVMMFLSKNISFGKYDSGLLIWAFGVSLLGATVAASYEQFGPMGIACFNDAFKGHKANMVLTTIPVPVILVTNIVLYIVTFIRIRSGAMIRSLGTNASAVKRHIKAAKRMSMFVLVFVAQWWCFGLVCAWSLFVDNLLEIPEHLNYFLVIFTNLGGVLNLVVYLLVFRNKSRSFMYNPRHMENKRNADLQPAIMTSSTKQHFSPKSETEVFLEMINNEESTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2S3</accession>
    <name>A0ABY7F2S3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="81" mass="8763" checksum="E2BA57468FE0E9EF" modified="2025-10-08" version="1">MEKLTFPLQAFESSPRSFSRKSVNCLILGLCLTHIALSQKKDTSVAVGVEASKNGVDGTITKKEFDNLSAVVINDCFRGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3C1</accession>
    <name>A0ABY7F3C1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">EXTL3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_031277</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF4">
        <property type="entry name" value="EXOSTOSIN LIKE GLYCOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="11">
        <location>
            <begin position="196"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="12">
        <location>
            <begin position="709"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="73"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR16683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="911" mass="104530" checksum="15C36C5FB97A43FB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F690</accession>
    <name>A0ABY7F690_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CALM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR17707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="78" mass="8615" checksum="D853F180D8438E28" modified="2025-10-08" version="1" fragment="single">MHNGTTLLVSGNGTIDFPEFLTMMAKKMKDTDSEEEIRGEKLTDDEVDEMIQEADVDGDGQVNYEGWFVVINDDAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7L3</accession>
    <name>A0ABY7F7L3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_031605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd06127">
        <property type="entry name" value="DEDDh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040393">
        <property type="entry name" value="TREX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058:SF22">
        <property type="entry name" value="EXODEOXYRIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058">
        <property type="entry name" value="THREE PRIME REPAIR EXONUCLEASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR17011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="311" mass="34586" checksum="03C0516D85339274" modified="2025-10-08" version="1">MSDVKIMTVLPSTVFPMEKTHRVKKRGMPCFAANTKLGTAMIDGLGGSSKVNNMLSTLNIKPVHRNNLQAIERRAGSYVENVAAKSTRKAANEAFVSEMKDVAEEESATAMKTMDNYVEFLGVGLLPDSSPSTRPGQQHLMMAGQTLTRNMAGFQLDHTERIHVDGITMVGDREMMVDGRPVTPSSWKSASIDFLNWLKKHKNAFLVAHNGRRFDFPVIMSAYTSVHQCDFLLEHTHGMIDSLPLFRKVFPKRSSYKQEDIVHDILGIEYKAHNAEEDVKSLASLVSKVVNDHGDKSVLENSFPAKAAYCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7V0</accession>
    <name>A0ABY7F7V0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_000115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="551"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR18277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="757" mass="86938" checksum="F4BBAAC7F0274045" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8E9</accession>
    <name>A0ABY7F8E9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CBLN3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_000301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF113">
        <property type="entry name" value="COMPLEMENT C1Q-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046408234" evidence="4">
        <location>
            <begin position="20"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="69"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR18463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="240" mass="27139" checksum="79A8D6486DE7A20B" modified="2025-10-08" version="1" fragment="single">MEGCMMWFLFACSFCLVNAHMRNFEEFEAEFYKLKERVSQQENALLLQGNKLIEQDQRLKYYEHALGKRFVLQDEETVAFTAHVSPYTLDHLNHLDVIHFDQVLTNIGGGYNNQTGVFVAPVSGIYQFSCSLMDHISDTHGDAMVRGEIIHNSMVIARVFAHADVKYRDQGAQTVFVHVNVGDQVFVRVRDNTNLSLGGDMYSSFSALMETSILFSAIPIGVGGVIALQQHANRPERKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F993</accession>
    <name>A0ABY7F993_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SIR2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_000448</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-hexadecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:14175"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138936"/>
            <dbReference type="ChEBI" id="CHEBI:189673"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:70564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-tetradecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70567"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15437"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:141129"/>
            <dbReference type="ChEBI" id="CHEBI:189674"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:70568"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="98"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="362"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="399"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="449"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR18610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="493" mass="56629" checksum="630F73E27FEC984E" modified="2025-10-08" version="1" fragment="single">MSTKVDKGLKKYRIIDCLLFPMISEKMLRSCIHTCHSNKSTRRSVTFSSENQYFERELNEEEIEQLEQKGWKDEKEKKWFTNYLAKSLGVYFGPDNEPLLDEVSFEGIARYLASDKCSKVVVLTGAGISTSAGIPDYRSPNTGLLATVKAKYPKMKDPKQLLELEYFIRDPKPFFTFRKDMFAIDYKPTPSHYFVKLLEVKGKLLRLYTQFSYGLPVTQMYAHKDSLVPYCTEEDCDGFMKPDIVMFGESLERNFMDDAEEIENCDFMLIMGTAMKVQPFSKLPIKTKFNVPRLYINLEKPQVARHPMTALFFGGGYDFDNEDNIRDVFVGDKCDDACFKLADLVGWGDEFRAMVQEENAKRGVVWPPSVQKPSPGPSHSKTDKPCPPTQSKTDKPQAAKNQPKSQSSVNKKTFSSGNITTQSKAVKTQSKPDIKIAARLITCDPPLLVEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAKESIMMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9J6</accession>
    <name>A0ABY7F9J6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_000685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044971737" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="28"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR18847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="600" mass="67078" checksum="8032FCF4DA167783" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9Z1</accession>
    <name>A0ABY7F9Z1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_030730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF64">
        <property type="entry name" value="C1Q-RELATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047351760" description="C1q domain-containing protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="6">
        <location>
            <begin position="140"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="62"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR16136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="275" mass="31206" checksum="C1A96E94E7C275B0" modified="2025-10-08" version="1">MTGFLQLLLFVSTTLASESSCPVCSKYDYEEKLLERMIRMEFDFRKVLTENKVVSETVEHDLTKIKKENKRLYGEVDALKAEHEQAERRLILLMEDVVRNQNITLEQAERRLVSLMEDVSTNSNNTLERISAAFDNITDQIATRSVYFHAHSPQTSTLSTGEVIVYERVKTNEGNGYNATTGTFTAPAQGLYLFIMQKCSPPNKYSYLQIMKEGSGLLTSAHYDEDNHSCSSSQAFVQLDFGETVWIHCSRGGPNAQLYEDSNHWNSFGGALFHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAW3</accession>
    <name>A0ABY7FAW3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_001083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042622">
        <property type="entry name" value="Znf106"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14435">
        <property type="entry name" value="ZINC FINGER PROTEIN 106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14435:SF2">
        <property type="entry name" value="ZINC FINGER PROTEIN 106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="806"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="947"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="958" mass="107817" checksum="B77CED39E4D3D72C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAY2</accession>
    <name>A0ABY7FAY2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZN561-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_032715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR18121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR18121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="192" mass="21959" checksum="24A39D6C039BBB58" modified="2025-10-08" version="1">MVCSKPLSNKTNKKKHMVLHDAQNMRTKATHLPCVWNWIYSTQPSPYPYEDSHGRKTVLLSSVWEILQDERNSSRASRELKRHVCQVCGTGFTRPNHLNIHMRIHTGEKPFSCHLCGKAFAAKRTLQRHMITHIGDELDIGTQIRVQISMTGIVAHGSNKLYTSEQLLHSHVRIFKGLWEIFDTEPGIVGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBH4</accession>
    <name>A0ABY7FBH4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein O-mannosyl-transferase 2</fullName>
            <ecNumber evidence="4">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MAR_001366</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">MELC-2E11</strain>
            <tissue evidence="18">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4"/>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="270"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="370"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WAR19528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="507" mass="57732" checksum="A76C377D9DE2571B" modified="2025-10-08" version="1">MSEKESGIPVKRNPSTPNSPKKKEGPVRSLISEKEHVLEKSQYPQMDKSGEISQSSVRDGSKKSDDVLKTTFTTKENDHPRNENLLYFTIWDETHFGKMGSWYINHSFFFDVHPPLGKMLIGMSGYLSGYDGEFPFNKPGDEYGDVQYVGMRMFCATLGAALVPLVFMSTWLLCRSTTAALFAAAFTIYIYMVVMVEYDGHLPVVLYRVFIVKHFLARALCLIGLPVICYMLIFAVHFKVLYKTGGGDGFYSSQFQSQLEGNRLHNVSMPDRLAYGSVFSLKQQRTGGAYLHSHWHLYPEEHPPRQQQVTTYSHKDENNMWRVKPAIEEADVKGPPVIVRNGDLVRLEHDGVGDANDVWQIKVPGAEEGSELMAVRSKLRLVHYYVRCALHSHDKKLPKWGWEQLEATCNPNTKDPKTLWSVEEVIDPRLPNVSFEVYHPSFLDKFLESHAVMTQGQIFSGMHHKVILLGNPVLWFGVHALMVLFLILYAVHAFRLQRGAKMSQIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FH77</accession>
    <name>A0ABY7FH77_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DPOLL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="30"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="392" mass="44132" checksum="EAB7E8597032880C" modified="2025-10-08" version="1">MDRRRKRTGDDKSPTVSKKRTLPDSVSSDKSLNCLATVKAFILPAGIEKMRLQIFETQLKKYGGTVLKLYDNQATHLIVDDKMEPNRLCRILKIASPPTRVKIVKSSWLSACFKRKELLCFDDYRLDCSTYIKSKEPDLSFAKEKATAASNSESTVGGNVKTKNMLPKAGFMFGHHSKNNIPASADDDDSDYCPSDGEGKPGDPSSGNNEFAVSPQKELPVGNWVCAQSSKTPVENQNKHITDILEEYFGLNFGPLLQEMVKTYESTNDKWRAFGYQKAIQVLRKHPKPIKSFEQNVISPKDSCFFFPTALDAAMPQEAMNLPSIGKRLAEKIWEIAESGELRKLKELRSSEELKVIETFQNVWGAGAHTARTWYQQTEQFETGVYMYVTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHI8</accession>
    <name>A0ABY7FHI8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="275" mass="31373" checksum="F3EFCED1B235D1F8" modified="2025-10-08" version="1">MTEYIGVLFETKLGPALTTLNTSYIADKKKKKKKKKKMKKKKTKEEEEEEKEEGEEEEEEEEEEEEEEEEEKEEEEEELLMKIIGKTIEFYARHLNCGINVTIHSNPLDISCNVSGISDGAIDYQHISLANTISCLYQHSSHANPNIDLLHGKGRGSSFLQEVLPNCILITSPGERTFTAQHSFNKTTIFIGPYTCNYPTARGMYMFFQSLETATFVDLRERNIDSSISLFMSGLVISHTEADTVSRNLLRENASYNETEKFEGQQQYLLVRGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FI10</accession>
    <name>A0ABY7FI10_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LDP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_002229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR20391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="199" mass="21979" checksum="EB87333223BE6477" modified="2025-10-08" version="1" fragment="single">MSDERYDFVVLGATGFTGQFVVDEVARVADQEKLKFAVAGRSMEKLQKVLTESSQRTGKELEETPIIIADVKNYRFYGEDVVKACIENGAHHVDISGEPQYLEKMQLLYSGKAREAGVYIVGACGFDSVPADMGVAFATEQFKEIHTHYTSISSIQGLAGNVTTLESALHGFAHAAELKPLRKSLYPNRLPRSKYPLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FL14</accession>
    <name>A0ABY7FL14_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">QRFPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_036564</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="290"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR22895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="365" mass="41537" checksum="B23C61F4D4B216AC" modified="2025-10-08" version="1">MPMTMAGKVYKLWVYGDVLCKMTPYLQGVSVTTSTFTITAMSLDRCLAILYPVKFRNLRTKRNVRTLIVLVWLTSFLLMIPLLFVNKTKTQTVFNNFKIVICSEEWTSVYQRRAYDFSLLFIVCLIPAQIVFVSYILMGKRLWVTDSALKANTSSKAVGSTRGSSHGPYDSVRASRRRTAKMCIVVSVVFVVCWLPYYTVNIYLDFKRDEGLLDIVYWGLFIGHLHCITNPILYCFMHKTFRYCVKRMLPCWRKSFVRTPSGYGTNAGNRMGSLVTSTRRACPAGERTHARLSQSCSASSSTSTATQPETSPVHGQDIKPPPRRVRLILMKLKRRRLCKESSNDSFKLVDIPSSITEEAPIETVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLY3</accession>
    <name>A0ABY7FLY3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_016153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR22179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="202" mass="22088" checksum="E99146CD558AFE26" modified="2025-10-08" version="1" fragment="single">YILTAIIVSGVALGAISHPRPVAVENPCNLVLAEDPIDTSDFISRLTDIQTRSEGSGKVRSFTAKVLDRYNFMETVSQDKISPALNSQVEALQSHYDFLFEYIVHIQDIKGADSLSTNIDVANAELLNALDSLENKIERTACSVVLALRAKGSDMLEYEPTLLNGYTSSPFSAIYNAYILANDGVKLGAYLKEMYGELSKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMR1</accession>
    <name>A0ABY7FMR1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TACC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_016190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039915">
        <property type="entry name" value="TACC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007707">
        <property type="entry name" value="TACC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924:SF10">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL PROTEIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05010">
        <property type="entry name" value="TACC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transforming acidic coiled-coil-containing protein C-terminal" evidence="9">
        <location>
            <begin position="575"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="591"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR22216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="635" mass="70191" checksum="5F5A747172DCA934" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNG2</accession>
    <name>A0ABY7FNG2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EFC14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_037427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042352">
        <property type="entry name" value="EFCAB14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15717:SF2">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15717">
        <property type="entry name" value="PROTEIN KIAA0494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR23758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="591" mass="64618" checksum="06029E1E8052439D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FP58</accession>
    <name>A0ABY7FP58_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RHBT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_016613</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd18499">
        <property type="entry name" value="BACK_RHOBTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="307"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR22639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="729" mass="83760" checksum="03025204B9A6726C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FP81</accession>
    <name>A0ABY7FP81_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SREK1IP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_037534</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Possible splicing regulator involved in the control of cellular survival.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31437:SF1">
        <property type="entry name" value="PROTEIN SREK1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31437">
        <property type="entry name" value="SREK1IP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR23865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="201" mass="23429" checksum="97EA8170CA3EC1A5" modified="2025-10-08" version="1">MESSVQGLPGFAKKASEGFKAACKKCGYAGHLTFQCRNFVRADPGKDVVLDVSSTSSDTSEEEFVSPLVKLRNEEDKEKTKKERKKKKHKRERSRSPLSHKKKKKRKHKHKSSQDSDSEISDSEESSIDSDDESSHKKKRSHKKKKSKHRKRSVSESFSDESEEEREQRRKKRKKKEKKKRKKKHRHRNRSSEDSESDSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRC6</accession>
    <name>A0ABY7FRC6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynamin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_038254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26392">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26392:SF92">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="2">
        <location>
            <begin position="179"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR24585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="433" mass="47332" checksum="C246BF8D77A5A909" modified="2025-10-08" version="1">MADGGSLQREIYSRVESHKDNTTDGTSVIGNSTDTMNGDADDAPALDPGSDIRLEDVESMDLGDVFDFLEAREVPCPDVVDLKEMHDLVRRTLRQEADNAPSCPAAGADDGRDGHLAEALTKDTVMKQELAEIYDRVIPFIRTGLNTDLRDPLIKLYGTNFEARLEQNRSELLDGECPIVVAGETSAGKSSLLNLLLGTDILPHSLLSSTSTICRLHNIRSTDKRRFVVYPEGGGASVCHNIEEGREKEALEKLKVAVSENRSNPGEYCSQVEIYWPIPLLGENTQVTIVDTPGVGESGEMTSRLFRYLPHAIAFIYVLNSANAGGIQEDRENSNIRLVSYEIPLFYSTTIFIHVINSANAVVLEGYNTCHTQPSGRITAVSIHVINSTTAGGLLKVSVIRKPLLTPPPSPSTSSTMRTQVADKRLLSRYTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FS55</accession>
    <name>A0ABY7FS55_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR23716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="43851" checksum="77775122C0BFC26C" modified="2025-10-08" version="1" fragment="single">MYHDASWIDWIVEDETVVIGCIYRSPSETDNCDIIIELLREAARISENLLVTGDFNMKDSGKHIQPFTHVQQFTRCRNDQPLNLLDLVLSKDENNVTNFEHLPSIGLSDHVTLVFDFCCNYKEVYTGNMSYSYRRCNLLAFIQDWESVNWKETLCDCDVNEMWSSFSEKYKVSVDKYVPKSKPKTGCKTKPLWMSGEVLSPIKKKRHAWDKYLATRRNEDYEAYKIVRNRANDFVKNSKRQYERNISQKAKSEPKQFWRYVKSKTKSRSNISNLKRENGEFVRNDKEKVDVLNEFFTTVFTKENIDTIPDIEDKDVNSELSSLTVSDEEVLKLLKDIDPSKSMGPDCVHPFLLKSMPDIFVEPLTIIFNKSVTTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUG4</accession>
    <name>A0ABY7FUG4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPED1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057106">
        <property type="entry name" value="NXPE4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14776">
        <property type="entry name" value="CADHERIN-LIKE AND PC-ESTERASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14776:SF1">
        <property type="entry name" value="CADHERIN-LIKE AND PC-ESTERASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24536">
        <property type="entry name" value="NXPE4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NXPE C-terminal" evidence="1">
        <location>
            <begin position="661"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="900" mass="100330" checksum="1D4289B6446736A0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FV10</accession>
    <name>A0ABY7FV10_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_011504</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="12">
        <location>
            <begin position="467"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="707"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR25800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="761" mass="86637" checksum="D3CC9B9EA558E711" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXJ5</accession>
    <name>A0ABY7FXJ5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRADD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_012604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037939">
        <property type="entry name" value="CRADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15034">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN CRADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15034:SF5">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN CRADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="119"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR26900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="207" mass="23928" checksum="0DBA523AFB4C696F" modified="2025-10-08" version="1">MREELQRKIKKNIIDIKKDMDAKDLVDHFVQEDVFDLPDDEEINGFNPNTAENRNKCFLAKLLKKDDRAYDVFLQTLHLVGLAHLAEQIENTEVATAPVVDPTSWLAQIAEHIRKRRLTERDLSRLAQSIGTDWELVASEMNLTRVEIDHCRMENSTTTMQVYSALYKWRNKVPGGATLEKFVDILMHCQSTTIDWDIVKKTAQQMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXW6</accession>
    <name>A0ABY7FXW6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_011576</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="11">
        <location>
            <begin position="341"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR25872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="474" mass="55512" checksum="31CF4F0DF5489374" modified="2025-10-08" version="1">MQRALFIGRIIFHIQKERDMSILYISKIGPGTKSFLIAEYDKTDDAFSEMWDWPLEFATNPNKNFRTKKNLLKYINEHRVALDSDNSRVFDEIQFYLDIVDFLMEWMVDNIKDSGFGDTWKTLVVFQKITRCTLDSGAERAYGAMFYAQGNFPSDAFYDFYFRRLARFTYSYKSATYYSDLVDPLLDERTDQKVYTEAIRNLRYEIRRSNFTADYTSLEKAQVYFDNATFRIDYLYRLQDMLADRVARRINTTIRIYNMEIIIYSVVASVIIAAFPVIVYFLEKLTSSMQAYSKILVKASTNLNEEKSRTDSLIYQMLPKSVADRLKRNSKVESEFFKSATVMFTSIVSFTQLSIEYTPMDLVELLNALYTTMDSRLEKHDVYKVETINDTYMINKISTIDLPTYVSCVLYAGSVSAGIVGTVMLRYCLFGDTVNIASRMRSCGLRNKQDTYQRFNIQKPQENWELQHKESRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FY66</accession>
    <name>A0ABY7FY66_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_012852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR27148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047430447" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="103"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="274"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR27148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="338" mass="37676" checksum="844C2E523B34F2E6" modified="2025-10-08" version="1">MIGHITALYALTAATLVAAGQNELVQCTPGEYKIIGKADCTGYYLCVFGNPVEMPPCPPGSVFSSSSNVCVNKGSIYDDCKKTTDGSGSHITESPDQGHLSPEERCNLYGGVFPHPTECQAFYNCSVRYTSIPRLYEQHLVECRYPQLFNTETKQCDNFENVKCGTRTEFKDGCKLASVYVFVVRNNSQYKYKVCGGSHCMPCNERLPSCVDKGDGITIHPGRLWTPFYVVCYKERTIKTDRCKPDVDGAQFFHPEKNECVSLDMIPREHGGMMPECGTKVDGFYLDDFGRCDRYVHYQRGKYIGTIKCAVGEVFDDTRGGCVPEEKACGPCGKLDHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZM0</accession>
    <name>A0ABY7FZM0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR27077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="213" mass="24405" checksum="F0FF6A07D99FD5AD" modified="2025-10-08" version="1">MVSEAWQPFPKRWYNEGLLVTTTKPKDDSQTQTGNSEGQGAGASSQGQISKLQGRSRGGGADDREGFLIHPTRGRITTYIFYTHIFQKKHNVHMYFDKDTGSWMRMPIVWELQHSMVKSLVDQVNVWFDCITLSTSLLESVPTWSDRNDILSLLRACDYDPDECISIYLNLRKDSEVDERPKYGGVRDGGRGDGTRMIWLDNKVRRMVHSLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0V8</accession>
    <name>A0ABY7G0V8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_010690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR24986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12859:SF0">
        <property type="entry name" value="PRA1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12859">
        <property type="entry name" value="PRA1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR24986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="178" mass="20067" checksum="FC2AD253D9B3D2BD" modified="2025-10-08" version="1">MADVQLAPLRTIGDFLLESARFQIPNINDPEKWANRVMNNLLYYQTNYFLMALVTFLFIGIIHPVKMVCGFIAISIAFGGFVYCTSSQYKARRFKRDHPIVSVLLILLAGYILVYAVGAVIVFMFGIAFPMMLILMHASLRMRNIKNKVTNRLETVGLKRTPMGIILEGLGQEQEAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0Y1</accession>
    <name>A0ABY7G0Y1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GIGA6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_013774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF15">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047155330" evidence="1">
        <location>
            <begin position="20"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="32"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR28070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="411" mass="46465" checksum="AF1BC13EE5A9833F" modified="2025-10-08" version="1" fragment="single">MRYVLRYFGAAFVLTNVRGAVFDGETEQDVVKLIQATLECRHVSGMTVGIIKENETWTHGFGMADLKSGRPVDGDTLFNIASVTKSFTMALLAILLKENKLHWKTTVSDILGSEYGFIDDYRTRETTLRDLLSHRTGLANPDIGFMAGFPPSLSREDMCKRMRYLPEQIPFRDSYIYNNYLYMLLGHVAEKLGGDTWENLLMSRIFVPLGMKSTKILKKTSDVLASDMAHPYIYKDNSFENSTLDIYELHPAEPAGAILSSAEDMVLYLQFVLSNGKTTTGDQLVDPMLFREAFSVALPVVRGDVIVSKPTFPVSDVVGGYGYGWFESSYDGYRAVWHRGTLWAYYSIAWLVPEQNIGIFISTNGGMFKDDQYTSLTTTLYYLADLLLDKEPWLNSSTSCSFPEPWKKVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G165</accession>
    <name>A0ABY7G165_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2 5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_013679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2 5"/>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173:SF52">
        <property type="entry name" value="METHIONINE-R-SULFOXIDE REDUCTASE B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044975787" description="Peptide-methionine (R)-S-oxide reductase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="48"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR27975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="190" mass="21363" checksum="2A2D090984FFBAC4" modified="2025-10-08" version="1">MNMRVVLGTIFWMNILHLISSKQEESPSIQKFKASCTETATCPVSYPREELREKLTPMQYKVTQEKGTERAFSGEYNSHNDEGSYRCVVCGNRIFSSDDKYNSRSGWPSFKDVISKEARVEVTCSRCGAHLGHLFTDGPEPTGLRAKRVEVKCADCRSHLGHVFDDGPKPTGVRFCVNSAALKFKKETTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G192</accession>
    <name>A0ABY7G192_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046958946" evidence="1">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="106" mass="11020" checksum="77279CA6F82BBB36" modified="2025-10-08" version="1">MLFKYTLVLLVCVILIGTSDAWLFRRRNKEKLVYTNGGVKIKLVVKRPASLVRPEKELGCKDIEGCGGIRDAPSGIGKAGGAAAAGIADGSADMRDAMAAAGVGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1C5</accession>
    <name>A0ABY7G1C5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative nuclease HARBI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Harbinger transposase-derived nuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_012637</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transposase-derived protein that may have nuclease activity. Does not have transposase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="13">
        <location>
            <begin position="144"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR26933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="339" mass="37895" checksum="7B6AA010320098C6" modified="2025-10-08" version="1">MAALFVFGQRRRKQRTFKDRISSLDHLSDVEVVDRYRLSRIAIIYLEDNLRNDLSPPTNRSQSVSSMTKVLVGLRVLSKGNFLSEVADLHGISKQTASRVLHEFVDAVNRNIDNIRFPRTQQELAEAKLGFYKRCKIANIVGAVDGTLVPIIAPKDSGEAYICRKGFHAINVMATCSHDRRFIDIVAKWPGSQHDSSVMNTSSLKEHMESERPGMLLADSGYPLTTSLLTPLANPVTPAEARYNNAQSKGRMVIEQSFGILKGRFRCLHKTGGVLSYSPEKSCAIFMACARLHNMCLDWGLTLDDAQVVDPGQDAMEAWMGQPGLQVQELRRRVVNTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1L2</accession>
    <name>A0ABY7G1L2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_013093</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR27389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="244" mass="28236" checksum="E77DF22C051903DF" modified="2025-10-08" version="1">MEEDKSDIQSEIEFDISSKEYHAAITRSHYVDVATRTCCQNKACGIVCMSCYEERSVCLLGVTRSVTDYFLEYRGKDREEQRQLTCDLVLQKEKCTTIRRFWRDQLTVDIYKECQRLIDGFSKAVGTSDTMMALTELRKILSVPSWQKSTFWQLDSGVTECRGCGKRLGSKRKHNCRVCGLALCKHCSVKELLLYFTDDKPDRPRLAIIRLEGRLEHQFRTTEVHAKRDSFIGMSRKACRKAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2D7</accession>
    <name>A0ABY7G2D7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HARB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_014304</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="184"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR28600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="282" mass="31985" checksum="14B6D22BAE439443" modified="2025-10-08" version="1">MERRPNLDDLTNIEIIDRYRLDRDGIDYVENILSRQITPKAYRNHAISARHKLLITLRYLATGPIQLNDCDIHGVSQPTVSRVLGEMLNVLSDPRLVRQFISFPTDAADLRRNATIFEGIANFPKVMGLIDGTHIRIRAPSEDEYMYETVQVVVDGEDKIIDIVARWPGSVHDARILRESGLSQLLDNGSHKTTRSRVEKAIGQLKRRFGVLHTEITLSPEKACKVVIACAVLHNLCIARGIPFADNQDDDNGNNNNGDPRPQDQMPGLRYRDYYAATYFHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2P9</accession>
    <name>A0ABY7G2P9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RS6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34226">
        <property type="entry name" value="PROTEIN CBR-ABU-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34226:SF1">
        <property type="entry name" value="PROTEIN CBR-ABU-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="beta-Roll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="389" mass="44963" checksum="4130B3C2DAEDAE86" modified="2025-10-08" version="1" fragment="single">DVCTTHDSKDVCTTHDSRDVCTTHDSRDVCTTHDSKDVCTTHDSRDVCTTHDSRDVCTTHDSKDVCTTHDSRDVCTTHDSKDVCTTHDSKDVCTTHVSRDVCTTHDSKDVCTTHVSRDICTTHFSRDVCTTHVSRDICTTHFSRDVCTTHDSKDVYTTHDSKDVCTTHDSRDICTTHFSRDVCTTHDSKDVCTTHVSRDICTTHVSRDVCTTHVSRDICTTHFSRDVCTTHDSKDVYTTHDSKDVCTTHDSRDICTTHFSRDVCTTHDSKDGCMYYTCFKGYMYNTFFKGCMYYTFFKGCIYYTFFKGCIYYTCFKGCMYYTCFKGCMYYTFFKGCIYYTFFKGCIYYTCFKGCMYYTCFKGCIYYTCFKGCMYYTCFKGCIYYTCFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2W5</accession>
    <name>A0ABY7G2W5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="84" mass="9191" checksum="66031200E29665E0" modified="2025-10-08" version="1">MTMKPLFDNLASGRPGGQSTDSVRNNGILTVCIFNSIYSKCTIGTCHSFFCRLLIAAMDLFSSMCGCRAVCHRSQRSKTMSKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2Z9</accession>
    <name>A0ABY7G2Z9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_014514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47611:SF1">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47611">
        <property type="entry name" value="HAT DIMERISATION DOMAIN, C-TERMINAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="3">
        <location>
            <begin position="148"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="HTH psq-type" evidence="2">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR28810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="59632" checksum="0850F127A4044C15" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G317</accession>
    <name>A0ABY7G317_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DYHC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="571" mass="65528" checksum="A6EE42C6E84545D5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5J2</accession>
    <name>A0ABY7G5J2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VPS13-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="2">
        <location>
            <begin position="299"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR29705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="401" mass="44268" checksum="9AE16CD411BEE424" modified="2025-10-08" version="1" fragment="single">MGLSLASEQKMFYDYLHLSPIKVHLSFSLQGGGDGKAMQLHANVINVFLQSVGVVLTDIQDVVFKLGFFQREHKFYNNKQLTGEMTSHYAGQVSKYFMYKAPDWEMTSHFAGQAIKQMYVLVLGLDVLGNPFGLLRGMAEGIEDLFYEPYQGAIQGPEEFAEGMMLGVKSLFGHAVGGAAGAVSRITGTLGKGIAALTLDDDYQKKRREALNKRPANVGEGFARGGKGLVMGVFDGVTGIVRKPIEGAKKEGVEGFFKGVGKGLVGVVTRPTSGVIDFASSSFEGIKRIAENVGEIHRLRPPRRFYKDAILRPYNKQEAEGCAVLIETEKGRYYNTDEYVAHVIFGSWNCEFTYTWTEIKEKPRVSAKGLEIILKEKEKKGFFGSTSSKKDIHIADKKIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7F4</accession>
    <name>A0ABY7G7F4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">STA5B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_032894</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.630">
        <property type="entry name" value="STAT transcription factor, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001217">
        <property type="entry name" value="STAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012345">
        <property type="entry name" value="STAT_TF_DNA-bd_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11801">
        <property type="entry name" value="SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="563"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="563"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR30352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="608" mass="67793" checksum="97040996950DF61D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9Z0</accession>
    <name>A0ABY7G9Z0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="243" mass="27428" checksum="8421310CA6AD6FC0" modified="2025-10-08" version="1">MLTKRKLSGTPSWPGWLDNHCTIRMKDKATTLSTQFSVKIFGEAIQVDPRPLFQRLTVTAKVSQDLALVFNHQPALFNTSLLLRWPHKLLTFDEDMPIAMKKDKFLGNNTNKQQFITCSVGCLKNKTGRTFYAQVLKQYLCRSACTHILFMHAILECDTTSRLYGIGEEAALNKVITSYHFREEVTVFGTPSTLKADVMAAGYNALVRLYNGKPATEPNTYLSRNILSQSPCKLTGVAEDRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GEI6</accession>
    <name>A0ABY7GEI6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR29606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="436" mass="47239" checksum="71641010146AC622" modified="2025-10-08" version="1">MTTTGQLDHPSPTPGVSPESAEDGGVRIVLIVLWVAGGVLLLSLCALLVCIIRSHIKEQRSTGMRAGTSGLAAPQQGSVNPTFSNYDEIWTWIPIVTEHSGNCQSQINPGQRNIDMTRRNTELVNNLRLPTYSEAVNGNGNVNRPLVSQVRMTSHITSGQQTSRSGAAGHQHLPSFVPSTGTSNNNRDVPVRHGETCVNIPIQGTSTSATSGPSTSQVIFRPTNTSTSRNNTTPDDIPVSRSSLHAHVTNISVTPSSVSALQQARALVEGAGSREPYKPLPSAPSLQQTEPENSRVSSSARPRNQLTSYIAQRTHSPRDSQTANNCVTDVHHAERRQPGVCIQNGPNENRESPVYSGHLRQDSYIMYPHHRRTQNSAGFRHSSGSVFNYFCSNGSRFTVQDITDGVHPSPYTLPEMTSTLVPSSGSLRSSMETQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GJH1</accession>
    <name>A0ABY7GJH1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_034083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR31541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="389" mass="43917" checksum="4C061E8C613CCC28" modified="2025-10-08" version="1">MMPNLQSHDQNTSRPFTFSHRVRIMRNLHPDVGKAGDSEMLPTKLTKWRRQCEQAMNYNGYGTHSQFGGLFKEALSCACLSRRTYKLLDNIMTKHNDLHISFKGNMIRGISGCYDELYIFSVLRQVDDGVIGPQEMNESLIKEKKNTRECRPSPDDPDAKQELAVLRAEVAKLRRELSQKAQKVASLEEELAKTKQTGHNGEARRDIFNFESPIPGNRTCRYSRPVFAPDSDSDDVSLGAGSSISDLENTNDLHANTFLQDNDIFTNNSLPDINMEPEMSSTPTSNSIIDEHHNESLTTTNCNMISNPELDDIFLTPEATILKPIPSETVIRGQAESNTHSRTRRSSKKRKNSTSVTQSMPCLRIGRQGTILRNFTQERFLQSSCLVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAJ1</accession>
    <name>A0ABY7DAJ1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_006424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tumor necrosis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471:SF13">
        <property type="entry name" value="TNF FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471">
        <property type="entry name" value="TUMOR NECROSIS FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="THD" evidence="6">
        <location>
            <begin position="186"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ93953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="322" mass="36278" checksum="B8EE7C6F583A91F6" modified="2025-10-08" version="1">MGFPCPDALGLSLLTDSREICCVFSNIYTKDNNDTPRGKTSRFEHIFFGLTVLSAALTILFAVLCIALGNKTNQSESTICLNCDELILSYSPFPHANKDIDALRQAENSSLCCGPLLNISKLLLTKATTSKHFEQSQTVTVGDGFYELLYDDCDKVNGIRTPKAKLAGIVDISPSLTVNGHSKLLWNRYNSTFTEHNCIHLFQEGEIFIKQPGYYIVSSMIHVRIPATTNNTLKLRPPTTNSTTLFVHHVDLLSHYYGHTRVLMQRKRSLGQTQMLPFTSLVSAVFKFQKNDRISVSVSHPEYINLNHTMDHFSVYYSYDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DD73</accession>
    <name>A0ABY7DD73_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Exocyst complex component 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exocyst complex component Exo70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_028286</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EXO70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="6">
        <location>
            <begin position="286"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="6">
        <location>
            <begin position="433"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ95596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="563" mass="62175" checksum="F161459C06B9019F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DEH1</accession>
    <name>A0ABY7DEH1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_028706</name>
        <name evidence="2" type="ORF">MAR_028751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ96016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="94" mass="10650" checksum="CE6EFBB66C397535" modified="2025-10-08" version="1">MAYLNNGRHRHATLSNIDDCPTSIEFNSVRDAFTQLHESLHPSVPDQELHANVYSKVYSDFIGRNKFLVADIQPDSQCHFVFAAQDQLSLLCEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DF76</accession>
    <name>A0ABY7DF76_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="entry name" value="Serralysin-like metalloprotease, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="111" mass="11585" checksum="3DDB754EEF986B99" modified="2025-10-08" version="1">MLYGDGSTDGHDNGMLYGGGSNDGHDNDMLYGGGSTDGHDNDMLYGGGSNDGHDNDMLYGGGSNDGHDNDMLYGGGSNDGHDNDVLYGDGTTAGLDNDMLYGDGKHRRTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFD9</accession>
    <name>A0ABY7DFD9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_029094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ96404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="80" mass="9210" checksum="1184522DDD39112D" modified="2025-10-08" version="1">MDTCQCCSLRPYMHLDLQEVIWCTSSHVRLTSPRGWVKLGQNAKATIDDQISRLNSVNYGPEPFFCLFFRRMADYMAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIC2</accession>
    <name>A0ABY7DIC2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DDX21-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_030127</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059027">
        <property type="entry name" value="DD_DDX21-DDX50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26142">
        <property type="entry name" value="DD_DDX21-DDX50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="62"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="209"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="482"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="572"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ97437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="599" mass="66790" checksum="D3CC3D5E3FFAE14C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DII4</accession>
    <name>A0ABY7DII4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CDK12-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_007291</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="523"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="820"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="959"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1080"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="320"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="838"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="889"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="904"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="933"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1080"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1116"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1146"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1178"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1198"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1217"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1261"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAQ94820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1303" mass="144872" checksum="A4CEE674B6F3FE6C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DN92</accession>
    <name>A0ABY7DN92_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CCNG1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_023535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="93"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ99162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="374" mass="42590" checksum="70653DB202D79E6D" modified="2025-10-08" version="1">MVEIEKLQHGENVENKENTKVEEFRSDFRVQADISTTTGSFSASAGFQRKIELLFVSLQNLTESQNNNAYTLNIPSSTVDGCITQSDRDSAVTTMRSMQRFYNFGSDTLAAAVYNLDRFISKVKIRKKYMSCVAAASFFLSSKMNEESEFYPSASDLAGLHRHSWKASDLKRMEKLILDKLDWNLYPAITSLAYLEKIYKILQLFNVSNSEINEEFFQSMVERSEICKYFGSCDLSTVFEGNRDVFFYEQVSDQELFECQCAISHLLHMYDTQPATHPKCLPTPRIVPRPNLIKRPSIYGSPDLPTIEEVSSEIRDEPETPDSPCHVVEDLSIVPYYKFSAPKSCQSYCLLLDQCFCSGNALYMCKSKCNISIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQI5</accession>
    <name>A0ABY7DQI5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_023751</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="539"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="662"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="893"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="580"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="598"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ99378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1056" mass="116870" checksum="00C99377213750C9" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DT22</accession>
    <name>A0ABY7DT22_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUR3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_022478</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="668"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="706"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ98105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="758" mass="82661" checksum="3DF89217366E703C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTR4</accession>
    <name>A0ABY7DTR4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025197</name>
        <name evidence="2" type="ORF">MAR_025306</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="170" mass="19615" checksum="F135F90D977B5835" modified="2025-10-08" version="1">MKPIPDSIWVWELQERLETVHNTVRQATGHAMKRQKQIRDKRNSYEHVDIGDKVLVYFPVRKPGKLSDVLYKVDCGRKKAEQVIHCDQSRVIWLYKHSLTWSTNCTLQPSLQVSCDANGGRVTGTFISPIRCEIRKAAVKKNPLLSRISRTIVYKVINKHNCNISGDHHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DU75</accession>
    <name>A0ABY7DU75_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TYR1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_024532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR00160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="387" mass="44076" checksum="36D1EB23C2021B94" modified="2025-10-08" version="1" fragment="single">DAPVDQDLASEACLRVFLDSRNGDMARFGRMHGQQLLRKHKGAGFLGWHRIFLAAFEEKLREVEPGVSLPYWDYTMDSYLPRPADSLVWSPCFFGNGVGKITEGPFAGMFGGFNVDIVRDYAPGGKCPPELISKNDFDRLMKFCYFKNITTGSGPYYGNPNNLELLHDNVHDWVGGDMSQIAFSSFDPVFWMHHTYIDYVWERFRRHQKKNCKHVDVESDYRPERDLSQNNAPGHSLTSPMHGFEYLQVRQGLSNIWTSLYYDYEDHPVCPDCGNSENLYCDKTVDPTRPKGVCVTKTHFFCVQPSVQLSETLVWNPKKELDMQHQGLPGDGQTGHVGHNKSRILASELNIGYLTVPNSSKTIFQSFDSRLLVFCIVTCSVFIILLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVM8</accession>
    <name>A0ABY7DVM8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="170" mass="19205" checksum="A9D2DDE2707068BB" modified="2025-10-08" version="1">MSEGMQRYSRPLRHCLLAPEHHVTLFQNVEKLVSMSEYQVHQMLSNLPDTEDAADPDDSLSVEPADITTIVGVIYKFKLPVILQAYSQYASGLPHAARSLADLERDPDFLRFLWRNEAHRQPLSLCEFINRPLEHLADVCRLVSAIRDSLSTGSSDHSVYSKIVNGKDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVU6</accession>
    <name>A0ABY7DVU6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="111" mass="12870" checksum="5C28C17A74F2E02E" modified="2025-10-08" version="1" fragment="single">ADAIAVLLCEQSGNRYAAVEEGHDIECITDHLGFGTVCLDLYELETAYYQDRQQYGVPQQEDNDLVLWERDGVRDIWEERCILYFHNVQLEEFGHSFNHGSIRDFGTPRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DX89</accession>
    <name>A0ABY7DX89_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DHI2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_008187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF50">
        <property type="entry name" value="GH26015P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR01629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="335" mass="36937" checksum="5AE32070B4446FA0" modified="2025-10-08" version="1" fragment="single">MTLFLHLSTMNFVVDDDDIPEDDVIIFSILYSCVTVVFAMAVLSKFLTNEFRFGFRSALSLAVLFLGEPLCQFFVKGPLGVGCFAAGCLLIYSILPASHLPVGNKAVVITGCDSGFGNALVKKLDAIGMHVYAGCLDKDGPGADEDISKAVEIVRLDVGSEGLWGLVNNAGVCYFSELEMTPEPIMRKMFDVNLFGTVNTTKAFLPLIRQAKGRIVVVSRRISFEGYGAYGMAKHALMAFSDTLRQEMKKWSVNVSIIEPTGYRTGRKEEIWEKLDENAKATYGLDYLDEIYSSLMEQCKTFPDDLTPVVRAMRSGLLSKRPKERYPCGAGADIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYV4</accession>
    <name>A0ABY7DYV4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFAP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_009481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MFAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="3">
        <location>
            <begin position="197"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR02923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="403" mass="47517" checksum="2AA6427AD67AB40A" modified="2025-10-08" version="1">MESSKPSVPILSTAGAVPVRTEKGVSMQKVKVNRYVTGKRPDYAPDYSSDSESDEDFIRVKKTTSTKPGPSHEEDEDEGGEDMDPRLRRLMEARKSRIDSDEDSEDDDRVARHRRQVIEPEVIAEGTDSEDERVRRHDDDESSEEEELDDEEIEKRRNLLRQRALQRKQEEEVLDIEDDKVGESDEESSEYEEYTDSEEETGPRLKPVFVRKKDRFSVQEKERNEAKMKEMEVEAKKMGEERRKQTLKMIEDERRRELEAARNTQDACDQLESGDENDEEAYESWKVRELRRLKRDREEREGMHNLTEEERRAEFQHNPKLRTNKAPKGKYKFLQKYYHRGAFFMVKNFGRSGRTKYTHLVDQDTTSFESPWVSETAMNVKFHSQKGGGMKQIFDRPSQKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E062</accession>
    <name>A0ABY7E062_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_008874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR02316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="551" mass="60695" checksum="14CA80862CB61F4D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E145</accession>
    <name>A0ABY7E145_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bleomycin hydrolase</fullName>
            <ecNumber evidence="2">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_009116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="2"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR02558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="199" mass="23261" checksum="DC757C0842CE6F4D" modified="2025-10-08" version="1" fragment="single">FSIAEIIKLRRSMVYRGVSQELLDRFQSQFEKSEKNILAQNVCTALPLWDVLASRACKQATQHCFNHKVEKEGTPMTDQQHSGRCWIFACLNIMRIPFMKKYKLDSFEFSQTYVYFWDKVERAHYLLNVFVTCARKGEAYDGRLVTHLLKNPSEDGGQWDMLTGLIEKYGIVPKVCFPEAWSAENSNRICRVLNNRIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1F6</accession>
    <name>A0ABY7E1F6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_009612</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF209">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="474"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="580"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="10">
        <location>
            <begin position="900"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="1012"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="201"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="290"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="368"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="864"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="866"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR03054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1163" mass="132771" checksum="80224830389A8238" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E452</accession>
    <name>A0ABY7E452_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047509398" evidence="1">
        <location>
            <begin position="21"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="144" mass="13106" checksum="A91BC9709F2ED996" modified="2025-10-08" version="1" fragment="single">MKFLISVFLGLVIAASVCEAWRWKPCKGKHCRRGYGGGYGGGYGGGGYGGGGGYGGGYGIGYGGGGGYGGGYGGGGGYGGGYGGGYGGGGGYGGYGGYMGGYGGYGGGGGYGGGFGGGFGGGYGGGYGVGGYGGGGYGYGGGQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4M6</accession>
    <name>A0ABY7E4M6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR03921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="258" mass="29145" checksum="6C243FC749DA31D0" modified="2025-10-08" version="1" fragment="single">MANWGECMNGMANWGECMYGMANWGECMYGMANWGECMYGMANWGECMYGMANWGECMYGIANWGECMYGMANWGECMYGMANWGECIAKIRPLMVCKVCNWPYTVNSNDYRCDHHNGIKQNVCHHHIVHFTTPESVCCRCQALTNRVNRLPPARALARPPIGQRLLYIRRYKAHAATPLHNTGKGVDINILDSTRIQKKGRHASTWPLLCDGPTGGMSFGKRTQDKLFKENADITFVEPSRDDAKSGGYEIDSDINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4Q7</accession>
    <name>A0ABY7E4Q7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_020369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31807">
        <property type="entry name" value="AUGMIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31807:SF37">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="754"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="982"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1424"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="757"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="988"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1002"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1431"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR05000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1541" mass="174723" checksum="133CB377A8550784" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6K4</accession>
    <name>A0ABY7E6K4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ARHGC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_019939</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd13329">
        <property type="entry name" value="PH_RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041020">
        <property type="entry name" value="PH_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015212">
        <property type="entry name" value="RGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872:SF2">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17838">
        <property type="entry name" value="PH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09128">
        <property type="entry name" value="RGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="12">
        <location>
            <begin position="340"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="543"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="389"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="459"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1039"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="949"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="113"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1107"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1124"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1141"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1163"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1207"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1240"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1278"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1323"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1334"/>
            <end position="1350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR04570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1356" mass="150499" checksum="93F147A87CA5A8C5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7B5</accession>
    <name>A0ABY7E7B5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FUCL6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_021299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fucolectin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051941">
        <property type="entry name" value="BG_Antigen-Binding_Lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713:SF15">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713">
        <property type="entry name" value="FTP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="8">
        <location>
            <begin position="42"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR05930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="181" mass="20863" checksum="936BD5A812BBE727" modified="2025-10-08" version="1">MFSGSCFHTKREYQPWWTVDLHQDYYITSVVVYNQLDHCCGTYNVAIGKTASQSSNHRIYEWLAPTAVDGIVGNNSMFSGTCFHTTKEYQPWWRVDLHHDYIITSVIMYNRLDSFAERARNIKRTIGKSLDSMSQAGYLDGGLTTHTFTVDPPLVGRFVRLQLKGITEFFHLCEVEVMAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7F0</accession>
    <name>A0ABY7E7F0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UPAR/Ly6 domain-containing protein qvr</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein quiver</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Protein sleepless</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_021357</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional regulator of neuronal activity in the mushroom body, and possibly other regions of the brain, that acts as a signaling molecule required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Reduces neuronal excitability by enhancing Sh/shaker K(+) channel activity; possibly by stabilizing Sh/shaker to increase protein levels, accelerating its activation kinetics, slowing C-type inactivation and enhancing recovery from inactivation. Specifically affects the A-type K(+) current. Antagonizes nicotinic acetylcholine receptors (nAChRs) to reduce synaptic transmission, possibly by preventing their localization to the cell surface. Required for regulation of neuromuscular excitability and plasticity at neuromuscular junctions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts (via loop 2 of the three-fingered Ly-6 domain) with Sh/shaker; this interaction may stabilize both components of the complex and may be required for targeting or retention of Sh/shaker to neural cell projections. Interacts (via loop 2 of the three-fingered Ly-6 domain) with nAChRalpha3 and potentially other nicotinic acetylcholine receptors; this interaction is required for antagonism of nicotinic acetylcholine receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
            <orientation evidence="1">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane raft</location>
            <topology evidence="9">Lipid-anchor</topology>
            <topology evidence="9">GPI-anchor</topology>
            <orientation evidence="9">Extracellular side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the quiver family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF31">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR05988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="331" mass="37594" checksum="E38BCA9CBDA490E9" modified="2025-10-08" version="1">MPAEGINNGDDMTNEPCPLRNVKTTDLEKYTAYLESSEIINLAMDFIIKDTQDIDLLYEAIVLILNLATDQCIPRVKYKPFIKPYWNDELTSLHEDMRHNRDIWDNAGRPRAGSDLHYVNYKISKANFRRTHRKAVDEFLKQQESNIDRAAALDNNEFWRLIKRRHTPTTEHKSFEMKFSDKTVSDPLRWTLSDPHTNTNTTMANFVIGFVVLVGLVTLFSVDEVFAVKCYSCNSLTKSGCKDPFKKDGIDELECPSGCMKVGGKDDKGNQVISRSCSPMKSNKCEEQTVAGIKGTVCFCEKALCNSAERHFRPWVMVAGVASIIAVLRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7W5</accession>
    <name>A0ABY7E7W5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_021324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR05955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="76" mass="8904" checksum="7763D3D12054B113" modified="2025-10-08" version="1">MTDQKPKPELGLLEEDDEFEEFPAEDWEGEEEDSEDVNVWEDNWDDDNIDDDFSVQLRAELEKQGKAVDTPEPMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E879</accession>
    <name>A0ABY7E879_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="entry name" value="Glucose Permease (Domain IIA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="752" mass="84446" checksum="2627ED1549012471" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8J0</accession>
    <name>A0ABY7E8J0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FBN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_021747</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050751">
        <property type="entry name" value="ECM_structural_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034:SF205">
        <property type="entry name" value="NIDOGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="394"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="784"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="867"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1037"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1124"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1168"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1136"/>
            <end position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR06378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1211" mass="130522" checksum="23711A8D068AAF9E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8R6</accession>
    <name>A0ABY7E8R6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBLN3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_020522</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF116">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C1q" evidence="4">
        <location>
            <begin position="7"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR05153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="136" mass="15693" checksum="769D11E60F26E07A" modified="2025-10-08" version="1">MENRPRYRYVPVAFSAVKTNNQRLGYRQAVVFEKVLLNEGNGYHAHSGIFYAPQSGVYMFTSSMLHRSEGITIQFAIIHQGRVMAEFHANAEWEQFSQTVIIRVRKGETVSVRNNRRNLPIIFGLSYSTFSGYLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E939</accession>
    <name>A0ABY7E939_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UNC22-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_021033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF32">
        <property type="entry name" value="PROTEIN TURTLE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="36"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="234"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR05664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="548" mass="61221" checksum="3CAEF53DCF24BBA0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9X0</accession>
    <name>A0ABY7E9X0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_016788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR06830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41852" checksum="297945B6487202BC" modified="2025-10-08" version="1">MTITIYIFHVFVVIWILLFADSVGQRSKCPPDMTDVQYELPVTIVKVCQDDWASGIATVFLDTSSAPTYANVTCACSVTSEHRASVSASFTMNSNTDTIWFEFPTSNLTGRQQNGIFVFDKSLAFRYWSTTDHNTLPACLKLLLTVTDPLRIPLRHQQHKHLVSSERRSLNQQAMPQWLLVRRKYSEENPSENYNHEMENQTNTMVDTKQGIDEDSGDKYKENIIISDTYASVGYERVVEPSGINPVEETSGTKATDDYYSTVSKDRNRNVNKKSDTDKHGNTTLGIKGNGEQEMRTNPQHCFNTAFDGSSDVYNHLNEKETVQPVNVYGSLTTNGDHPKDLLKEYDHIEQQTGEMEHSKKDETYDSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBT5</accession>
    <name>A0ABY7EBT5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ACHAA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_021490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044992094" evidence="3">
        <location>
            <begin position="18"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="4">
        <location>
            <begin position="25"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR06121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="348" mass="38744" checksum="A2B381FE8C673E1F" modified="2025-10-08" version="1" fragment="single">MWISIMLYLLTIHVCKGGAQYLASSRLIQELRTGYERHVPPTRSFDSHVSVRVYPSIIRIDGLDESREALSVTISLSMNWSDQRLTWNPAQYDGVQKLFLPADTIWLPDVGVHNSVDGLISEPSASHLVEVSHVGHVLMVSVMHVQTYCKMTLTDFPRDVHVCDVIIGSWIYSAKTLILESWNGMTVIEQVPVSSDIDDVIPSRDGRSWMLLGRAASGAIKLVSYDCCPDEHYVQLTMTLTLRRHAPSLWLTLVVPLLVLSFMTALQFAVPAGNPYRPIHGMLVLLAEMMYVHSMFSYIPDSVDPPIIVKLAVANVMCAAIALCVSLLVGHVTSTSVRQRKRLPPLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECB4</accession>
    <name>A0ABY7ECB4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_021956</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="214"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR06587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="450" mass="52515" checksum="31F07E7F60891C31" modified="2025-10-08" version="1">MPYMIQAMVTWLPRRVRRKLRGGSDWVSTLYYTLFYNYFTSLYVALEVMLEPLFWFVEKFAKYLGPVFVTLVVVMTTSVVTIFYVCLLPHVYTTSLPWTIFHLIFGHWLLVNIVFHYLMGVFSQPGTPPPQVNKDTIVIYQSPELFIKEYLVYKAAYAIFEISLCKCSESELQTNDIKCCILTFQMGHGKTLQSYNSELSVFTCILQNVPEIVSVCKKCISPKPPRTHHCTICGKCILKMDHHCPWLNNCVGHNNHRYFFLFCVYMWMGTIYVSWVGHDLFRQHFYGDEPTAFPPLFYPLNAIHDAIYRSNDPAKPMSIIINPNPPPKENYIEHYYHIAVLYEFILCSGVTLALGLLMLWHARLISKGETSIEVHINNTQRKKYKKKNLVYRNPYDYGLKKNWMVFLGFHSCRTFICKVLLPSTHPPEGDGLIWSRASYKFKQDKGLQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECN2</accession>
    <name>A0ABY7ECN2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PIF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_017733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF8">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13245">
        <property type="entry name" value="AAA_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="4">
        <location>
            <begin position="648"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="3">
        <location>
            <begin position="981"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="5">
        <location>
            <begin position="1858"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="2068"/>
            <end position="2250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1419"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1476"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1441"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1482"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1495"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR07775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2363" mass="272097" checksum="E60554E17739B5C0" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDW8</accession>
    <name>A0ABY7EDW8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="8983" checksum="E872B4258F824AB5" modified="2025-10-08" version="1" fragment="single">MKHEAEWGRGGWSSYYNVGVEGMPYVRGVGVAGCSKCKKCMHSDCVNIAEAELPSWSTKHARFFCPKCVFSGDEYNAGSALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFG7</accession>
    <name>A0ABY7EFG7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_017782</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="190"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR07824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="430" mass="49670" checksum="447BE25773AD2F03" modified="2025-10-08" version="1">MTGFLNRSYFCQQCKKGYNIKEKHICNNPYIYCHQLHADEEEKWRFWTTCNRSFKSDLCYQMHLKTGDAGKMKITMQQPAEEDTSSSKRKDNLTSYIFFDFECTQDEQLQCEQGYTVRKNGKCENCKKACCGSFEHRPNLCVAQKVCGKCLQNPVTPQSTCQACGKNEHVFQGIETTDNFCKWLFSEENAGATVICHNFKGYDSYPILQYLHDNAVLPKMITTGSKYMSIEVPNCNIRMIDSLNFIPMALAAMPGSFGETELSKGYFPHLFNRKENQNLVLSSLPDIKHYTPDSMKPEARQAFMKWYADHKHTAFDFQKEILRYCRSDVDILRRCCLKFRILFMDLTKKGDTKGIDPFAKCITIASICNLTVKDMVTGKDKDCVTVVDENKIVRNPSTGHIITKRENKDYKIVFDKRVIGEIFCTFPYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGG9</accession>
    <name>A0ABY7EGG9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="86" mass="9778" checksum="8A7C1340416F7A22" modified="2025-10-08" version="1">MEKDKRQHLLIKGIQSIGLQQTLAAVVLQFETPNRQTSMPVFRPYQSRPKAMWLPGGHWSSYWEHLMSEPKHAVAVRHPSLSGGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHB4</accession>
    <name>A0ABY7EHB4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GATA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="253" mass="28674" checksum="93FC16F6F6F03383" modified="2025-10-08" version="1">MILVSLNFNLGGFVEVALPCSKNRKLFVAEVIDVQEDEVLFRYMEAARGGFKWPTVEDVSWEHHSSVTRHLDNPVLDIQKSSNHEYYAPGLCDETHQVWSEVADMLENNGAKVTQVSLPHTQADNMESTEALYSQSRHEGFNDVVREDFNKVYNSGVDVLLTPTTLTVAPQYSWFQKADNRTRTAEQDVFTQPVNMAGLPAVTLPVKLSASGLPISLQVIGQRFKDHRMLNVAKWIEMNSDFRRLDLSFLDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIV0</accession>
    <name>A0ABY7EIV0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3421 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF1">
        <property type="entry name" value="FARNESOIC ACID O-METHYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16096" checksum="FD09273A14014ABE" modified="2025-10-08" version="1">MKNMAVWESCSGGVIPPSAVRAGYEADGKPLFIARARMDDGTLNPGKAGCHLPGAHIPWGGKENIVQNYEILVQPVDAIGHYEWQRDSGGHVPISAMSTDKGMFVGRCHHEDGLVPCKVHVHYGCAFIPYGGEERRSSEYEVFCRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EK54</accession>
    <name>A0ABY7EK54_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="114" mass="12421" checksum="FA1F031D1868273F" modified="2025-10-08" version="1">MNSALKAPVEQLSSVDEEIFNEPPVLERSVPLSIYGAETMVDYLSESGQNQAGDFSLNISGLTSAETSVLHSTITELSDADAARVTFNLGTNFGMERNKRNLPPLYKVRPTNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKY0</accession>
    <name>A0ABY7EKY0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">E2F8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_019007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR EFL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="7">
        <location>
            <begin position="204"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="599"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR09049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="876" mass="96117" checksum="0B5B91C16F253D4F" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENQ6</accession>
    <name>A0ABY7ENQ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="144" mass="16856" checksum="7CE96DE84FA066F9" modified="2025-10-08" version="1" fragment="single">MLVYGVQYCDFVVLTQPSGTPSLVIIRVQRYSQFIDNLEKKCNAFLSHHLLPEFMTSKLRNKQVVNTPTEDVQTWCICEEREYGKMILCSNEDCQIGCQCHYGCVNVKRKPRALAKKLTFLIHWPEREEVMSSRPQCFKETYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EP19</accession>
    <name>A0ABY7EP19_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027897">
        <property type="entry name" value="DUF4559"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15112">
        <property type="entry name" value="DUF4559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="344" mass="39466" checksum="B0E6742BA82E2ACB" modified="2025-10-08" version="1" fragment="single">MANVQVKDIRKDKRKQNYDSCKAALDQTGEALLPFTEDKLKDLHQQISLQVGNQPVCHQQCSKVMRDVNRWCITCGLWRQALLRFHTNPRELVWHKLQSWEWPKHHMNLVEVYMWQNWGKADMNASDLSVALTVWRKCSVFPATILPLADKLKKSRNKIAHGKSLDENEKQTVFNNIKQVIQHADVVKCLQNPNEILKIITDLENGNLFKSENRTIHWIFIAACIIVPIALFQPGIIIYCLSMIFSRPQIQSSMEKTGCLQEYSPLLPTSPLLVDYFKQHGPLVGRGWLFQLLDEHLNNTKKNGILLEAGMGYGKSAIAAHITCAKEGDQGMEMRKRLIAFHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPS2</accession>
    <name>A0ABY7EPS2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026150</name>
        <name evidence="2" type="ORF">MAR_026153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="53" mass="5793" checksum="08C9D26A970E70DE" modified="2025-10-08" version="1">MMIVQQRLNICNTSYGDQTGRKLGKWLSTNSPSAWLIRGATALNITAQSGVHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPZ5</accession>
    <name>A0ABY7EPZ5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35684:SF3">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="376" mass="46233" checksum="0C73A654CFE919E1" modified="2025-10-08" version="1" fragment="single">MVTTYHYIMVTTYHYIMVTTYHCIMVTMYHCIMVTTYHYIMVTTYHYIMVTTHHHIMVTTYHCIMVTKYHCIMVTTYHYIMVTKYHCIMHYIMVTTYHYIMVTTYHYIMVTTYHYIMVTTYHYIMVTTYHCIMVTMYHCIMVTTYHCIMVTTYHCIMVTTYHYIMVTKYHCIMVITYHYVMVTTYHHIMVTTYHCIMVTTYHCIMVTTYHYIMVTTYHYIMVTTNHYIMVTTYHYIMVTTYHYIMVTTYHYIMVTTYHYIMVTTYHYIMHGNYIPLHHGYYIPLHHGYYKPLHHGYYIPLHHGYYIALQHDNYIPLHHGYYKPLHHGNYIALQHDNYIALQHGNYIALHHGYYIPLHHGYYKPLHHGYYIPLHYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQH1</accession>
    <name>A0ABY7EQH1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="160" mass="18951" checksum="61AB77CFDF0CA280" modified="2025-10-08" version="1">MRLKQGAEEFHKQIAAVTIQLAWRKYIRRKLLQSLSPNKRQLRMWDPELVAMKQRALVSQIYGEQIDAPFWHPNMYRPQRPYWTKLAPSSAALSYNFAIDQYHPLVAKKGCLPSPFLDERGHPKEFLWQMIDEDELQGQLSLVKLESQSQSRNYSYNMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ER90</accession>
    <name>A0ABY7ER90_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SDH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_036154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR11078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="246" mass="27531" checksum="F075B98AFE92C597" modified="2025-10-08" version="1">MEEGRDVLPYFIKSEDMQLPEFASSPFHGKGGPLAVSTRYDFEITQFFIQAGQELGYNRTDYNGYDQEGFGVVQSNTRNGIRSSTSIDYLRSARHRPNFHILLRSFGTKVDIKNDCAVGVYYIKDSKKHYVKARKEIIISGGAVNSPQPLMLSGIGPKRHLSDLGIPVVADLPVGENLQDHMTIMFHSQINKQYGIISEEILQTVWNKIQYVIFGTGPLSATGLGGSAFIHLDPQSRGKNTLIFKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUC4</accession>
    <name>A0ABY7EUC4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="259" mass="29318" checksum="B549279024491E2F" modified="2025-10-08" version="1">MANVLSDVYKSDSLLNDTGLLSTTNTSMFDNGNSTFQPVENKIDKESEVDKMLKLVPEVMKQLADAGVSAKMFAFFKQVHSGIFSLDKIAFGTENAVDMPYSSITKVFWKLGFRHFGARFINFMVQAVWSNCCWRNQQRKSANWKLNINFAVPSVNVLQVNFSDENPSKPGIFVDVIETLANSMKDKYCCITFDGIKLKQGLTKTESDIDRLGFEKDISLKDKRVMYEHMLKPMNDIIESLKEAENIDLRSLTDEGKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EW25</accession>
    <name>A0ABY7EW25_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SVEP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_026908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF4">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="79"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="112"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR12728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="242" mass="26194" checksum="E935E1CD43A4FA1F" modified="2025-10-08" version="1">MANEYSCTCNSQWSDSNCYTPAPCSTPGEVSQGTRSFSDTNHASNVTYSCNAGYEITSGDATLTCNHGSWTGSLPTCEDIDECANNPCQNSGKCSNLVNAYRCTCNSQWTGTNCDTPAPCSTPSEISQGSGTYSDTLHGSTVTFACISGYEIKSGDASRTCSYGSWNGSQPTCGGNLQMSSIRISPRMIILLFLTKAIQNDANSATKYKRMRYKPLCKPGCMFKQPRILQLHMHISMGREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EYC5</accession>
    <name>A0ABY7EYC5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="371" mass="43557" checksum="C4D17E03EDEFD715" modified="2025-10-08" version="1" fragment="single">MDRSFATKLNTVLEEIGVSKDLIWKRRRTFLMRECLVNHSRVLRSLDEVNVFYLGSQSEGTTTVGMMSDTDQLECINHWEAILTLEDWTYGKDETSPPQYCNLQMFRYDQPLPYTDDTMQDYIRDSQGRILLQNTFIYNYRLKHIAETLQLHVRCMSYISAQKISNNTQGRSQMIELYTMEHEYLETLSNHSDDLMRRTFSMLNPFLISLTESVKLAAKIDNHERIAANDIFERFVIPKDPAHISNLLKCASICISCRHFEKATDILNYVEGLIKPYVVQFSGCYQRENPKFNDEFHSRLVEFIDNDEHLLRSSVAMSVKFGRLEIPCVPKHLVFEMYRTFRAVDKTDRHPHNDMWMDAAVVDAIPFLHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F001</accession>
    <name>A0ABY7F001_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="389" mass="43921" checksum="C29A17EA43EF8667" modified="2025-10-08" version="1" fragment="single">GKAGVDPRRLKLALEPECASVQCETLSMAFKGAVTVQGSQFMVVDLGGGTADISVHERKADGTLKEIHISSGGPWGGIFVDENYMKMLNELFGEKAITELRKTEMNDYFDVIREFEHKKRSFDTEKTNQLIVRISASLRDLAEKYSSKSLEERIGTLQIDNVIAKKGKDKLQFDTAIVKAWFERPIDLLMRHLKSILAEPKMRSVHTVILVGGFGESPYVQRRIKSEITGVRLIVPSEAGLTVLKGAVRFGLNPDIVHVRAGYRDFDEKKHPEEKKKLLNGEWSVPKCLNVYIRVIDEVEVNQQVIMKSIPTCEITLTSVYRTTHENPEYTTDPGCELLGTIRLECSKDIPLQHQVLETTFMFGDTELLVKKKNMSTGKVAYMDFECFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2Q3</accession>
    <name>A0ABY7F2Q3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="37675" checksum="450F44C4A2DCF1DA" modified="2025-10-08" version="1" fragment="single">QTERYEPKPVREPYVAPKFDYHTDGRFHNSYPSVPVQTPNTRQRYDSRQLNSNYYFQDKEDQTHKGYLVMMRVAPRSLAEVVNAVQGSVSSITASNGYCVGFAEPYKVKVLRPSYSYHNDAWWDPRDDRHQARYAVVVFWFKDASSARMCFESVGRFKQPDFPDSNPLQIVAIPLTYGRNRDAAPFSPESDHLTLFWTEFPSIHEGELYDFMKHYSEPAKKLMQEYGGNPYIAVCQYEAGWGPDLNKFGSPGYARYEVEQRRVGRPIKNAWLNPRTIIAVSSFPDMEALDAFYNDPRHKDLLGALGHFAEPVMIGVTLVRIRGTSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F363</accession>
    <name>A0ABY7F363_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MRC2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_005744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="14"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="159"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR15639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="229" mass="25908" checksum="A0A10F8E73B45CBB" modified="2025-10-08" version="1" fragment="single">MHYAASEHGTIFSVGDKCYELVPTLRSWFDAENDCRHKGGHLAHIGDSSHQQAINNVVQQYHGDQGVWIGLHDLQHEEHFQWTSDCVGLGVHQYHGRWEDLTCGQKIAYICEFGAVIPTTTSTHIVNTPPSNVLEGNSRLCPYTVQQYASHYNTLLVQHGRSCYELLHNKVTWSHGESLCVKAGGHLVHINTAQEQAYIQALMMKYNPNYAVWIGLHDKNVEGQFQWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4S4</accession>
    <name>A0ABY7F4S4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_031782</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="382"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="745"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR17188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="852" mass="96640" checksum="3DEE9ADD4AECECAE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4T3</accession>
    <name>A0ABY7F4T3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="320" mass="33496" checksum="4FE10CC6A67E92AC" modified="2025-10-08" version="1" fragment="single">MTVAAVLHSGSSLWRRCYTVAHHCGGGGYMVDHHCGDGGCIVDHHSGGGGYIVDHHCRGGGYTVDHHCGGGGYIVDHHCGGGGYIVDHQCGGGGFIVDHHCVGSGCIVDYLCGGGGYIVDHHCGGGVTQWIITVTAVVTQLTITVGAVVTHLIITVAAVVTQWNITVATVVTQWISIVAAVVTRWIIIVAAVVTQWIIIVAAVVTQWIIIVAAVVTQWIITVSAVVTRDVGYIVDHQCGGGGYTVDHHCSGGGYMVDHHCSVGGYMVDHHCSGGGDMVDHHCSGGGYMVDHHCSGGGYIVDHHCSGGGYMYNYHCRRGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F965</accession>
    <name>A0ABY7F965_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="231" mass="25337" checksum="60085037C38192FD" modified="2025-10-08" version="1" fragment="single">CKDDRGEPRSNILNETSKDGRYSFSCYDYTIGVKCVVKKLDGKCPDFAINIFCNCTAGPRSLTTKEITRTRTTTRTTTITTKRISLKTPKLTTTGKIATTLPTSIGVSASTPLYRFQSFSRGSTSETLDPPRTTMTTAAVGSKSRGNEPNRNTLDIGSLSIKWWQFLLILTVILFLVSLITSLCLFRRATALLRASKGDSTLPSAQINMTGCRGVLFVVLCLRAVADTNPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9F4</accession>
    <name>A0ABY7F9F4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="37774" checksum="EFFED7338FB4BEF5" modified="2025-10-08" version="1">MGCVSSQEARQSRFRTTSKPVRSGYLLYNDGHSKWKKVFAVIFQDSVMAWFEKPKKRYALGQTNLQSVCSMLVIGPVCKRIPTCPKKIPKKLSYSYMIAFPLWVQPGATGANLSSPVCFFMCPNGGSMGQWMTSIASVLPPPVAPPPGGNAAYPPAQNGYAQNGHPGYGFNPAVTVNPTAPPPPYSQQQNHNQRPQQTTVIQNGGHRRSGDHDFSKGLLVGAALGYGFGSPWGWGWGWGWGYHPGFGWGYGDYDMDVDVDVNVYNDYGDNDVGDNFDNDVEDFGGDDFNDYDPGVEGDVDFSGADDYGGGDYGGGDYGGADYGGGDGGGGDGGGGGCGGGDGGGGGGCGGGGGCGGGGCGGGCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9P0</accession>
    <name>A0ABY7F9P0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_001691</name>
        <name evidence="2" type="ORF">MAR_032468</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098">
        <property type="entry name" value="AGAP001331-PA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098:SF16">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="112" mass="13141" checksum="4D20BD20B3A7509D" modified="2025-10-08" version="1" fragment="single">MELNVKRRRNKKWNAEEMCAVADHVSDNYATLFGSFDSSNEITKTEKNSIWQSVTEIVNSMGNCRDRDEVYRKWVDMKSLTKKKLVEQVKDRNLTACVEAPPVKRKMEVKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FA06</accession>
    <name>A0ABY7FA06_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_030745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="3">
        <location>
            <begin position="31"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR16151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="263" mass="28925" checksum="9CF14C88CDE0B412" modified="2025-10-08" version="1">MLCKGTTFLVRVFCLIFGYLTFTKGAAPVCSPDTYTITAGIASTINTVFTSITCTDADDPTLTYTLDTTKDGYEYFTMDSNQLKLVNRIDVEDGLNSWQIEVIVADSEGDMDTATVTVSTFTSTTTTTTTPPPPGYNWFDDSNNTILFIVAMATVAIISGVCVVMCIRFRRKGTCLPSNCPEFNKCKASFGRQVTCCPLEKVKKVKNNKTNEPKIEENETEFSRLPSVSPTLITNSRLRDVGFDGMREPGFNAPMHTSYGGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FA89</accession>
    <name>A0ABY7FA89_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MTMR9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048994">
        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF73">
        <property type="entry name" value="LD06050P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="2">
        <location>
            <begin position="98"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR17603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="497" mass="57083" checksum="C7CC13AAF56A6D43" modified="2025-10-08" version="1">MEFAEFIKTPMVDRVNLRKPFCKPLLHSSVDSVEKRLSGSGGVVMIRCKDFTRLALDIPTAEECLNVAQSIEQLSHIDDITLAYPFFYRPTFDILEDGWHAFHQESEKNRYKSLLKEDWRISTANKEYRLCQSYPQSVFVPKAVTDEMLVKVAQFRQNGRFPAVLMRCSQPLTGASGKRCKDDEKLVNAVLGIGVRGGGYEPEAHYSQWKRINQSIERRPVFHESLIKLIEACSDTSATQDKWLSKLESSGWLSHVKDILTCACLVAQCVDKDGMDTTLQVTSLAQVIMDPDCRTFTGFEALIEREWLQAGHPFTDRCAKSAHAITKQRQESPVFLLFLDCVWQIWQQFPCSFEFTEDFLILLFEHAYSSQFDLERRCLKLESRTVSLWSYLNRPEVLGRYINPMYDPNPMVIWPSVAPQSLLLWNGLFLRSHINQCKQEEAWTEVAKIRQYDKELRSKVTKLRRHLVCLEKEATAAGVILPATLDGDVNGFELNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAG2</accession>
    <name>A0ABY7FAG2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galactose mutarotase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Aldose 1-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_000048</name>
        <name evidence="7" type="ORF">MAR_000182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-galactose = beta-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:28675"/>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:28677"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR18210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR18344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="116" mass="12886" checksum="17E3645DDB20219B" modified="2025-10-08" version="1" fragment="single">MPLKQELFGKTSTGEDVYKFTFTNENKVTISVLNFGCVIYEIKLPDRDGNVVDVNLGFDNVKDYEKNNNYFGALCGRVANRIGNGEMTIDGQTFKLSRNDPLGGHIVHGGFVGFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBC3</accession>
    <name>A0ABY7FBC3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CNIH4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_001273</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR19435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="114" mass="13368" checksum="FF1CC7930764B249" modified="2025-10-08" version="1" fragment="single">LECDYLNARTCCEKLNFWVLPEIIPQAVLTVLLLITGHPFLFVLYGLCTAWIIYRYAKKPTGNIGLFDPTEIHNRQQLKSHMKENLCKMGFHLVFFFIYLYLMIYSLIKGDDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBS4</accession>
    <name>A0ABY7FBS4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="108" mass="12789" checksum="01A0023EC461251A" modified="2025-10-08" version="1">MFPDIEYSHNEEEEEREKIFHISTVTDVQQINDLLIFYGVEKITMKEVLTDLNIMISSIYFVIISSLCFFLFLMILDIAILLYFEKHILNIFLFILDVNTTKCILKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FD34</accession>
    <name>A0ABY7FD34_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="89" mass="10330" checksum="1831902B718C3B9E" modified="2025-10-08" version="1">MTVATSGEGRFFTSNLIQAFVYFGRNKKYVNEASFSFNTVISCIFDITCVFDAIVHNVLLENTPENLSCCRYLFWNFVYDKIIKYKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDK2</accession>
    <name>A0ABY7FDK2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl-CoA hydratase domain-containing protein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_031945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play a role in fatty acid biosynthesis and insulin sensitivity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052377">
        <property type="entry name" value="Mitochondrial_ECH-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602:SF1">
        <property type="entry name" value="ENOYL-COA HYDRATASE DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR17351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="173" mass="18821" checksum="F089FE5D4782541B" modified="2025-10-08" version="1">MTSILSRTSLIECIIPRNVATTTERLTDRRPCSPRHNSVTRRANQQRGKGIPYKSLATAAGCQMVASCDIAVVTEKSKFATPGVNVGLFCSTPAVAVGRSVPRKVAMEMLFTGLPITAQEALLHGLVSRVVSEENLTEGVMVDNLAYQDGQEGIKAFVEKRHPTWSHSDDKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDT1</accession>
    <name>A0ABY7FDT1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CADM4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_002110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF136">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046054847" evidence="6">
        <location>
            <begin position="25"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="7">
        <location>
            <begin position="30"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="7">
        <location>
            <begin position="325"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR20272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="478" mass="52250" checksum="1FE9D5C5AE2C1017" modified="2025-10-08" version="1">MLSLNLRITFVVIVVCRMYAGADGSVTISSSEVTVPEGLSLTLTCNYTGIDKLYVIRWTNNGKDSGHKYDITIEQSEPCTIFGKPGLDKTLFTYTCFTLTILNVTRDNQNDNLTCQANLNFNSGNSVIVSVSDAPSDPPVIEGYASGGTYNMIENSIENLTCSSSGGNPLANLTWSCFNNQMSSPIEQGRTVKRVVQWTARRNENARCTCTASHAVRPNKHQTAFVNVNILYSPSTPLFKLDNTAVGSSIRIVSDTIQTVECDSSGNPYPTTSDFTWIKGTNVVGTGPVLNWPGGVMVGDDGSYTCTVETTLTPSDQNPPKLQTFTRESALEGYSFMIQCVYSVGNPARTKSTITRLFNGTSWSGDSHTMHSINRADAGLHRCTVENTMDPTGADTQTGTDTADFEINAHPDLQTITVSYDEISLDSYTEIQESDNLGFNAAVTYEIMPVEKESTDYDALKDPVYKNTKRKNSMQKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGS3</accession>
    <name>A0ABY7FGS3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="194" mass="21311" checksum="2552DBF68F18C3BC" modified="2025-10-08" version="1">MMIGVATGLTAEAQGEGQDPGVVKKAEDPAPRVMREGGQGRTVDQGQDHHHREQQRGGLEVAQEPQTEIKDVTNGNKKYKIITFHGQRERSPHTNKLRTRVTNICGYRRRQPNRSAMGGPLPGGTAFMITVSPVPGEKEQGQRERSPHTNKLRTRVTNICGYRRRQPNRSAMGGPLPGGTAFMITVSPVPGIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHW4</accession>
    <name>A0ABY7FHW4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_002302</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF147">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="12"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="210"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR20464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="347" mass="38889" checksum="79BCA4349ACC8E3C" modified="2025-10-08" version="1">MANVVRNPATPYVAPIPGGVHDGTVIHVKGIAERHHNGFLIALQCSCSIDPRSESPFVFNPRFTDNQVIRNSLRGGSWGAEERHGGFPFNQGSSFDVAIHIKQQHYSVHVDGRHFCDYSHRMPKERVTHLTCEQGIRIKEIRFEGGYPQPGHHGHHPPHHGHHPPQHGSGNIGAAFGKFVGGVLNEMAHAGQNNTPSFPGSGPIYNPPVPFVHHLGGLYPNKMIVISGIPHPGASRFTVYIQHGSHHEPHEIAMCVDARFWFNNESNSVVRNHKQGGWGSEERTIPFFPFAQNAPFEMIILVEHHQFKVAVNNQHLMEFRHRIQPLGRFDTLRIDGDLRLTQVRFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FI69</accession>
    <name>A0ABY7FI69_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_015018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd04371">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052095">
        <property type="entry name" value="UNC-13_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999:SF6">
        <property type="entry name" value="MHD2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1100"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1127"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="5">
        <location>
            <begin position="617"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="735"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="818"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="943"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="947"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR21044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1184" mass="132898" checksum="57025F6CCA3129AC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FI93</accession>
    <name>A0ABY7FI93_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAR11-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_015894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd01439">
        <property type="entry name" value="TCCD_inducible_PARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF2">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21240">
        <property type="entry name" value="Nup98_GLEBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="6">
        <location>
            <begin position="360"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="7">
        <location>
            <begin position="395"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR21920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="598" mass="69457" checksum="DE6CD788F709D138" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIF2</accession>
    <name>A0ABY7FIF2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="197" mass="22603" checksum="2A6DCC09628E65CC" modified="2025-10-08" version="1">MIIQKKGLLVNIPILEVMIMFRNYNKEDELAITEQLRGPFSQALEHGEAMPADRSSSELDVEVKPLVRKLFDEKREITKVSTGCLVLSIQCHDIGAVISLVQDNLSGKFGSLFEPLEEVMRTYDDHALFEVYVVCQVSEKCGKRSYTVESTVQDDGIAVKIQRFLESFTEKENRRVIFLERKTRYIQDYCGKNDIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIP4</accession>
    <name>A0ABY7FIP4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="7">PARP</shortName>
            <ecNumber evidence="7">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_014780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057044">
        <property type="entry name" value="PARP14_KH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF67">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23084">
        <property type="entry name" value="KH_PARP14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="177"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="272"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="10">
        <location>
            <begin position="713"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="681"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR20806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="899" mass="101012" checksum="E1FCF9A7127D8DC0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJK2</accession>
    <name>A0ABY7FJK2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="142" mass="16092" checksum="137D07659CB69D57" modified="2025-10-08" version="1" fragment="single">MFTLHWILLEEPKPPQLPLPLIEDVLGTFHHKIHAHILGDHLFCLRKRAPIQWGITHEKNGLDAYCRTGGMTLVQTGIWHHESGILGASPDGFVQGDYCGRVHLQDKEQPVMSPDIIEVKCPFSAKDMTITEACHSKKDFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FK02</accession>
    <name>A0ABY7FK02_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="92" mass="9586" checksum="684E34679C89DF24" modified="2025-10-08" version="1" fragment="single">PSVTPPAALKSCKGFLSQSSVTPSSRPVVDPASPPPTARKSCEGFQSQPIVTSNRPPIVTPLQPPCSHVKVSNLSPAYTPIAVSNDPPPPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKV7</accession>
    <name>A0ABY7FKV7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphotransferase</fullName>
            <ecNumber evidence="12">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_016191</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd24019">
        <property type="entry name" value="ASKHA_NBD_HK_meta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="12"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="14">
        <location>
            <begin position="208"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR22217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="456" mass="51415" checksum="1F6A1A758E98BFB2" modified="2025-10-08" version="1">MPTTPEKLSKYEKLSSLTYRRVMHLLHEEMNNGLSANYNLKADIKMFPTFVRALPDGTEKGKFLALDLGGTNFRVLMVMINERDVDIQSQTYLIPQRIMLGTGIQLFDHIADCICRFIRDHDLKNETLPLGFTFSFPCKQEGLAKARLSKWTKGFRCEGVVNEDICVLLHEAMKRKNTTSVDVEVMAVVNDAVGTLMSAAHTDRNCEVGLILGTGCNACYMESLENVGLWEGDFEEPSQVLINTEWGAFGDNGCLDFIRTEYDRELDTYSINPGKQIYEKMISGMYMGEIVRLALERLSMEGLLFESADRDCELFHKGRFFTKYVSEIESDHDDFFRNVKQVLEEIGVTNYTSEDCKIVKYICTLVSARAAFLSSAGLATIINKLEKPEITIAVDGSLYRFHPRFHNLMVLKIQELVKPGLKFKLQLSHDGSGKGAALVAAVAIRLRDSKQGRCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMW0</accession>
    <name>A0ABY7FMW0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR22922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="665" mass="74220" checksum="AAF05BB04D39DF05" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FN13</accession>
    <name>A0ABY7FN13_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stn1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_037114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015253">
        <property type="entry name" value="CST_STN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09170">
        <property type="entry name" value="STN1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stn1 C-terminal" evidence="2">
        <location>
            <begin position="77"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR23445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="132" mass="14766" checksum="E8DC237A2E47531B" modified="2025-10-08" version="1">MVIAARGYRDHEGGSPRKRPSHCTSVGLTPAIATNVGYSVAQDLKAILNAVVSSTDQCLYTLDDLWVFTKVKDFLTVHYSEKGCHYLHILDELHATLPYSKLKKEALMYCLNQLEAQSDVIRTTHAHYLPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FP43</accession>
    <name>A0ABY7FP43_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIE2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR23902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="118" mass="13648" checksum="7E40A83D7DC64253" modified="2025-10-08" version="1">MEFCPHGDLRTHLRECRKRKQKLYSNVQNQNQLSYSQMLKFALDVASGMSHLADRQIIHRDLAARNVLLDDKFVAKVADFGLSKNDDTYVKTTRSKVPVRWLALESIFSNTYTIQSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FS32</accession>
    <name>A0ABY7FS32_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR23526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="92" mass="10010" checksum="0F8D07A31C4267D4" modified="2025-10-08" version="1">MKAENDVELSDVAVGINDRTTCDDPNGEQQASGYEEHEDKEIVSVCNNEYSSLLYKIDDVPPFAVMITVAIQVADLPIGVFNLLGPADGHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTE9</accession>
    <name>A0ABY7FTE9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_038238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="137" mass="14864" checksum="D495EFE94CF73F57" modified="2025-10-08" version="1">MGYRAMCANTDLTTGMFTHCASQLFDDQCFSVLTTALTSAAINYFVPQDYANYKISYCSALSTYVSCLSVQPSGSCTSEMAQFANDIMLASAQFEGCGGQTHAFFTTYEGDIECSASHVGTNIVITLLVAMCIRLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FU09</accession>
    <name>A0ABY7FU09_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046801242" evidence="2">
        <location>
            <begin position="24"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="332" mass="38389" checksum="46B3DFBF7B37727A" modified="2025-10-08" version="1">MAQRITWSFFLLVGFAAVHQSLSLSNVEFYEKLKPYLELESIMRNSSAVDVAEEELETVANDGSDVILLPGGPDDELDIAFLLKELGFTPGNASESAVDPEIASLLDAFNLAPRKVCIRVDYRSYSSYLLSFTLNGYRLLYTYNCRKYRYRHRSTTNCRKYRYRHHSTTNCRKYRYRHRSTKNCHKYPYRHHTTTNCRKNRNRHHSDTNYLGRSTYQYCYHVHHLVSPSSRLCAQLYSINRSRRTMCARITGTVNIKGHVHSAYQNIGCFRIPCHTDNQAIERQEGTDDLPSDDFDPASDDVDSGSDEKNENQDGSFEDSAEDDSDSAERYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FW32</accession>
    <name>A0ABY7FW32_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RIC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33998">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33998:SF2">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1265"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR25051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1265" mass="143324" checksum="C2AE5F7C865A0F54" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWJ2</accession>
    <name>A0ABY7FWJ2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="396" mass="44776" checksum="9F177E747FEA977A" modified="2025-10-08" version="1">MFKVFDIDGGKSQEVSWSSLDSERATYSYFHQPLSCFCGVCTFEEAAPLPARNTVSWPRLTFGDLQLCGGDCCCQPHVHRYRMLMFVTYPAAKQSEALKFQGIFRRAFPAEEGRQWQLRVENSYGCTSDSIHIVQALKRITDTGGRLVSMALAGSISTQLSWQRFLMVGEMEEECEYPYWSDSVNKTSANQVGVNLFYEMPPSGGGGGPYIYQVVPCPISSQLNLGIPRHNWVSTIPWETVISQYLGSGWKLVEIFEDHAASKNTNVQKMFSFNIRLQNNLLWIFEKPASRRDDPTPLYECTMVETWKVNAVDYDGVFTNVGVSTNLSTNWDPLLDHYGRSGWQVVRIIDTPDAQRQGLRLREGFVEDGFGNPSYLRPDAPPAYDEVHAAPSPEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWW4</accession>
    <name>A0ABY7FWW4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HMG box-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">HMG box transcription factor 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">High mobility group box transcription factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MAR_011318</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">MELC-2E11</strain>
            <tissue evidence="19">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003652">
        <property type="entry name" value="Ataxin_AXH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036096">
        <property type="entry name" value="Ataxin_AXH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039655">
        <property type="entry name" value="HBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15499">
        <property type="entry name" value="HMG BOX-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15499:SF3">
        <property type="entry name" value="HMG BOX-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08517">
        <property type="entry name" value="AXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00536">
        <property type="entry name" value="AXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102031">
        <property type="entry name" value="AXH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51148">
        <property type="entry name" value="AXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="AXH" evidence="18">
        <location>
            <begin position="252"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="16">
        <location>
            <begin position="452"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="14">
        <location>
            <begin position="452"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="160"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="419"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WAR25614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="529" mass="59200" checksum="A5D959818F353064" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYQ1</accession>
    <name>A0ABY7FYQ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MYCT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_012794</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR27090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR27090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="286" mass="31423" checksum="828AEA19432408B3" modified="2025-10-08" version="1" fragment="single">VRSDEAAIWLSALTAAVNFVFTLLGLYLVEKIGRRPLTLASDIVSLLLLAVGFHVASLNTPQIPAPEKLSSNYTCSSHRTCNDCMMDISCGYCFVDNEGTAISNSSCLPTGTDNPWVSGMGQCSQQTLPGKLTWAYDYCPSPFSWMPMVGLVLYLVTFAPGMGPMPWTINSEIYPLWCRSSAISVATFTNWIFNLFVSITFITLTENLTRLGTFLLYAGLTGLGALVLYIWLPETKGKSLEEVEGLFAQPWCGTVNGADYNTKTIQYVQIRGLNRDGRESELDSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G023</accession>
    <name>A0ABY7G023_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_013491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR27787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="279" mass="30723" checksum="A93ED345887313FA" modified="2025-10-08" version="1">MSEVNQTDLGEYDVIVTTGAQPYLEASHPSRKITRYVRPCVDVGLKTSTPDRNDVITKEEAGLPTRSTVRQKRKTFEWHKNLVLCFSILVGFILGFAVCSVMWLTIDKLKQDTIVCELGDNNGDKDDVVTTHSSTNQVRFSSETTTSTTLSGSSSQRTSFESATTTEKTHFSSLSTTTASSPKATTEISSDKTTEYELPTNLQGGIVTSNVSRRLDGNASTARNIPTSEVNDTDMRVYDRMSTTGDQYNLGSNYTSPKYTSNIRPCLDVETSKPDKMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1A0</accession>
    <name>A0ABY7G1A0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR27019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="133" mass="15686" checksum="2174E43B75C6E85A" modified="2025-10-08" version="1" fragment="single">MSYTHVAVSYSRSMADVIHTGGSFARLVDGRGRTHRWQFQTFTRWPRSYTHLSCSKIYPMPADIHTGACIVHVHDGRGRTYRWQFRTFTRWPRLCTQVEVSNIYPLAEVAVFHFYPVIHTVCTFIKWPRSYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1J5</accession>
    <name>A0ABY7G1J5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_012968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR27264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="325" mass="33981" checksum="58F28EF66EAC5DEE" modified="2025-10-08" version="1">MAQHQEQHQERSLSSQVKDIGSTSSDVTDSDGRPPVICSAVSDPAVVTSLVMLVADSNFGVVSSNKFDFASVCTSVMTVVSTLVDGKEGGEIGVFLEITSDEGDNSVLLSNEKVPVFIFTVIFSENEVASPVSCTKDVGVSPVVVIEDFMDLLVVSGTDVLMSSGTGTAVKVSSSFDALIIVVDISVSASDVPSLILVISLSVDPSIIVVVISTFAAVDALTLSVGVIEDAIVSVTSVVWTIGLVFSVFVGRDGTVTVFVLIALVTGYVTFTAVTFSKTDSVLVIRVILTEDSQSNGRHDHSDKGEDKKHTEEHSTGGATPETIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2W2</accession>
    <name>A0ABY7G2W2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_014249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR28545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="194" mass="21080" checksum="B223FBF37D46905B" modified="2025-10-08" version="1">MAEKTKRVALVTGSTSGIGLGIAHRLASAGCDIIVHGFAPQNIIDDALAELRSQHNDCKISFAGANFLKEDEIDAMCMEVLKLYPEGIDILINNAGFNEVCLLEDCSMELWHRMIAVHLTSAFMLTKWALPLMKKKVQLLLAEFRLDQWFAGSNPTKKPVSVEQVAALVGFLCSEEAASITGSAHSIDGGYTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G395</accession>
    <name>A0ABY7G395_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="107" mass="13423" checksum="2B7E474963293CB9" modified="2025-10-08" version="1">MEIEQLQMWARWLELQRDRAIAVLELEQEEEAEGRRHRRRRQMRRKIWMKQWLARRPLYGHYEQLLQELNREDPKGYKNFLRVDADMFGELVDRISPRIQKKNTNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3T9</accession>
    <name>A0ABY7G3T9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014531</name>
        <name evidence="2" type="ORF">MAR_014534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="110" mass="12412" checksum="729701BEBFCC3610" modified="2025-10-08" version="1">MEPFLTSTCLQEVKQKVLNIERLAMDGDSTTFTCVKRSLFPDLKKSNDRNHIKCFSYGISQNKGNAHGIKTSLNALSAHMLNEHSSCCPTWCKSLSTRITGRRTYCRVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4Q2</accession>
    <name>A0ABY7G4Q2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="331" mass="37865" checksum="4C1677AF49B87F4E" modified="2025-10-08" version="1" fragment="single">NASLSERCVSHEIDYLPKTDSDNSPESITDISSEISELDESMISDTSPCKSAESDVFIEISYLNESMISETSSNFESADTISDVEMSSDEDTHFSHEIDSNDEMANVQPQSLSETELQALKIFSLFKRHNFTTSASRDIRQTMKSVFPSSECVTVLNLDYIYSFVDIPPMKEVHYCEICNGVFPDNLDDFRCRVENCEGFRYKGGFSHQQKKDRQPRKSFILADIKQQLKHLLKTPGILKEIEKCKEEIEDRKNCRNLTDITNGQAYREILNEDNSFLQSPYNLSAIINTDGVNLYSSSRIELWPIFMAINELSPKARFSRDNMLLVGIWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7F6</accession>
    <name>A0ABY7G7F6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IIGP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_002815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027897">
        <property type="entry name" value="DUF4559"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051515">
        <property type="entry name" value="IRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341:SF17">
        <property type="entry name" value="IRG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15112">
        <property type="entry name" value="DUF4559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRG-type G" evidence="7">
        <location>
            <begin position="541"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="469"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR29247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="912" mass="104229" checksum="55BA1E55A7AE775E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7I3</accession>
    <name>A0ABY7G7I3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF51">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31943" checksum="3132C8CA70276F72" modified="2025-10-08" version="1">MSLRDFKYEGGDFVITDEMKNAYKEDGYILVRGLFSTEEVAHIEKAIIEGPILNHSYGVDDGEGKKAHMVLWNHPGNDVTGMVGRCEKVAGSCEKLLGGEVYHYHTKLMKKPAKVLKSSHKCGRIDHVRVGNQVGADVSRVDEISKVCPLQFVEMVAGDALFFDCNLLHCSSANMSEARRWAFLCAYNKADNNPTKEHHHPRYTPLQKVPDSAVVECQEFKDMSGKSFNSITKETKSLEEVKQQEVKDGAILECKEIHDMTEKWFHKLGDETNCEKSKTEEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G856</accession>
    <name>A0ABY7G856_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COCA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="143"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="189"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="407" mass="46638" checksum="F5E3D58CEB4805AE" modified="2025-10-08" version="1">MYHSHRLERTRQRNAAVLIQGVMRGWYVRSVLARLKRKAVLELGRSWPRFVTEYRELAARVRARHGASKPFCNMDLKMMERFMDKQLSMRKQYERVFRRICPNGKLNKDDLMEFFNGCDLWPTQNDINRSFDAIYRGSRNTAEVVFALDCSTSTGVVGFHSLIKFVKELVSLLDVAPDRTRVAMVPYNEAASRPGVQKIGIVITDGRSTEPEKTSREAQLVHEMGVQMFAIGIGNKTDENELQTIATNPDCVFRVLDVKELGGIRRQIERRFCLDTGSLFAPIISSDESHLFRPVSQSPSLELVWNCYPPEACGLAHARRSRWIRPVVKGQEAWALLDDNIMRATGMRACLKLVIKARLHREGYVTLPSDVTNDVEHVTSEVQALHLIEKYIESQKNNIKIKQNVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9G3</accession>
    <name>A0ABY7G9G3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ACT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_033587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR31045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="376" mass="41790" checksum="C07B3D7BEF0CB567" modified="2025-10-08" version="1">MCDDEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSASLEKSYELPDGQVITIGNERFRCPESLFQPSFLGMESAGIHETTYNSIMKCDVDIRKDLYANTVLSGGTTMFPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9N2</accession>
    <name>A0ABY7G9N2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LHX3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_033657</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd09368">
        <property type="entry name" value="LIM1_Lhx3_Lhx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09376">
        <property type="entry name" value="LIM2_Lhx3_Lhx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049594">
        <property type="entry name" value="Lhx3/4-like_LIM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF128">
        <property type="entry name" value="LIM3, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="9"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="68"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="297"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR31115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="325" mass="35933" checksum="3238EFBC69336E98" modified="2025-10-08" version="1" fragment="single">MPAGKAAIPKCAGCGEPILDRFILKVLERCWHARCLQCADCHVQLTDKCFSKGDHVYCKDDFFRHFGTKCAGCDKGIPPTEVVRRAQDNVYHLECFACLMCSRQLNTGDEFYLMEDRKLVCKTDYEAAKARGEEGFGDYGLDDASKRPRTTITAKQLEALKRARAKEKRLKKDAGRQRWSPYLRQLKKGGDMDSSLSDDRSEDGMTDYHPDLEELDPGSVHSGRLSSDLFSSPLDHDQSLPGPHAPHGPSGSPPMDGWGPYGGLMGGPGHGFLDRRSPGMGAQLMPMDGMPPMMVGPMGGRMMPPDMPDNGRGYPDYSQNSNHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAM8</accession>
    <name>A0ABY7GAM8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="82" mass="9383" checksum="FDA525655E41D5B0" modified="2025-10-08" version="1">MSGIVLRAECNYIAKGSHRRVVRLFIHWTRTPAFIISYVHFRIQTSATVTRLLWISQKQSVAMSTTDKRLHDSSCVPSPRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBJ7</accession>
    <name>A0ABY7GBJ7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000366">
        <property type="entry name" value="GPCR_STE2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00250">
        <property type="entry name" value="GPCRSTE2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="280" mass="30481" checksum="E59D0591CCF4F218" modified="2025-10-08" version="1">MSTSLCSLIMNVSLYSLIISVSLYSLIMSASPCSIIMCASLYSLIMKASLYSLIMSASLLIMSVSLCSLIMSVSLCSLIISVSLYRLIMSVSLYSLIMSVSLYSHIMSASLYSLIMSASLYSLIMSVSLYSLIMSVSLCSLIMSASLYSLIMSVSLYSLIMSVSLYSLIMSVSLYSLIISVSLYSLIMSVSLYSLIMSASLYSLIMSASLYILIMSVSLYSLIISVSLYSLIMSVSLHSFIMSESMYSLIMSVSLCSLIMSASLYSLIMSVSRYSLIMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GDT0</accession>
    <name>A0ABY7GDT0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GPI8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_034036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR31494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="305" mass="34559" checksum="A20B2D0ADECBCC39" modified="2025-10-08" version="1" fragment="single">MAAPMAVKKNMNAFKIIAIGWLSILMATSFSKAVDMEDFFTSEHTNNWAVLVDTSRFWFNYRHVANVLSIYRSVKRLGIPDSHIILMVADDMACNPRNPRPATVFNNANEQINVYGDDVEVDYRGYEVTVENIIRVLTGRLPPSTPRSKRLLSDENSNILVYMTGHGGDGFLKFQDAEEISSVELADAFEQMWQKRRYHEAFFMIDTCQAESMFQKFYSPNILAVASSRVGEDSLSHHVDPSIGVYVIDRYTYYALEFLERVEPNTKKAVDPKPIKSPADPSIIVQSDRHKNASDIGKSMTLGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAT1</accession>
    <name>A0ABY7DAT1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="310"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="50858" checksum="BB520A4FE86FB95E" modified="2025-10-08" version="1">MESIVNMASSEHWRKKGNELYVSVKEGLAPTVKTERYKQAIQCYNRAFDMGKTEDDKTSAAKNIGMASWRLMKVHSESDCYSPQYRYTLFYHIKEAFKFFSFAYQHGFNVKPLSWVTGVLTSCRACWEDVATNVLDVFDIELRCQAIYDIAMAIEVKEVKSEAFLKLAECQFHRGIVAIQDKDYKKCLNAMRECYMPINEAGRISPEEQIQTEVRVLEQDVLMHTCMAESMQARDIGDALFEKVLRDEESLNIDMVDITEVELEAISLSRLGRVYGRVLKLKYKAKEYYKLAIQLAHSMYPRTFVLEDWFQEATTSLAEYQSETVQAEEERKAAEKKEVLKTLEKEIKLLDSKVDVSHDEFLKFVYNKFPPKDKSKKLVLPKQTESDRLTKIKKTLQKAVVHYHPDSIDEKLEGQKWKVLSEEITKCLTRRYETMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBD1</accession>
    <name>A0ABY7DBD1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_006165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Golgi apparatus membrane</location>
            <topology evidence="1 5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF63">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 5" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="6">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="7">
        <location>
            <begin position="250"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ93694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="320" mass="35684" checksum="1A85C4A4C4464CF6" modified="2025-10-08" version="1">MHNCEKEEYRSDLPRASVVICFYNEAWSTLLRTVHSVLNRTPASLLHEIVLVDDGSDLRLTHLHSQLAEYLWHLHPNITLVRTPKREGLIRARIYGAHVASGEWLEPLLTTVAAYKKPTIAIPVIDMINPGTFEYKPSPLVKANVSKIAPIETATMAGGLFACGGQLQIVPCSRVGHIFRQRRPYGSPNGEDSALRNAVRVAKVWMDDYIQYFYQTQPAAPSVTNYGDISDRDIPGDGHKVRAVDRKEPIVHEASSLCIVPENGEAKKDVRVILAPCTGKADQVWHETEDQELMLTSRLCLDVSDKDTIQGRAKLGNDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DD09</accession>
    <name>A0ABY7DD09_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ZBED1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_007279</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF9">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="489"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAQ94808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="640" mass="72003" checksum="8FD34B67BF85A258" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DER1</accession>
    <name>A0ABY7DER1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_007380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF26">
        <property type="entry name" value="PEPTIDASE M28 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M28" evidence="3">
        <location>
            <begin position="95"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ94909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="369" mass="41331" checksum="DD5803BC25269944" modified="2025-10-08" version="1">MQIFTQCIGIFSIFYQATLGADLAYINSTLTQHFSDTRHHVTNPAYKSQALQFIYDEFQKHGLDTNYHNFTFLGVSYTNVIGVLKGERFGTYDDKLVGVDDNGSGVTAMLESLRQIAAGIQGGKRRKNTIIFMAFDHEEYDDQYYGLIGSRFAIDQWLLPWLTRSYGQHLESLKPSGIIVLDTVMNYNSSTLSQVFPTEAEQIFLQYFPKTVASIASDQFKGDFLATIFRENLDGNLASTFNSEWLGEPQPQFEIEKFEIAIDADLNMFSDLLRSDHVNFWNTSIPAIFITDSANFRGQMQQCYHNACDNLANILTDNNVQFLGKTADTIAATLDKLSEAYTTGTSGASSVGDLISALWLSIGLMLIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DF25</accession>
    <name>A0ABY7DF25_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GALT5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_007500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF131">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="56"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ95029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="266" mass="29840" checksum="07E27DF2D5C34F54" modified="2025-10-08" version="1" fragment="single">MGLRLSPEDLQTYNSGLKNHSFNQFASDMISIHRSLPDARSKSCPRTYSTTLQQTSIIICFHNEAWSVLLRTVHSILDRSPPELVKEIILIDDFSNMDHLKAPLTYYMSLLGKVRVIRTRRREGLIRARLVGLGASRAPILTFLDSHVECWPGTLECSNTGNVTSNNTDETVVVAPTITFISSHIFSVTGGESGSVGIFKFPDVNFNWMPVPPRISKMRKSPADPIKTPTIAGGLFSINKDFFIRMGKYDEGMDIWGYENVEISLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFM4</accession>
    <name>A0ABY7DFM4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_028398</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFB10 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019377">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039993">
        <property type="entry name" value="NDUFB10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10249">
        <property type="entry name" value="NDUFB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAQ95708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="153" mass="18712" checksum="E079FD33EF769AD6" modified="2025-10-08" version="1">MADDEHETDPINSRLYEKQQFGTLEKFSSLIREKLVLPFRRAERPVYYHRKFARVPTVDQCRIDDEICKMEAGEQHKRDKMVDMCKVKILRKRLSECNWYWQENKFEKCSEQRDDGEIGRTQDVYENYMKQKHRMIWLRRRHEAGDTNAKYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGG1</accession>
    <name>A0ABY7DGG1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KLHL6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_029452</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="61"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="609"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ96762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="631" mass="70543" checksum="F675692CADD9CB3D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DH47</accession>
    <name>A0ABY7DH47_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="246" mass="27091" checksum="691384DA153AD230" modified="2025-10-08" version="1">MSTVDRRFLQVCQEVCVYHPTTAVLTRRVQITSASVLIVMWVWPEMPACMCCFGFVNKETQGRSCRKVSPVSQLKSTKLGRNIRAVQQGVMAQKYEVGDKKKLISKRDETCSIDTSFTSSDTSSSSSNQPGQIFEVGDKNRDISTSEETSSSESTSCGSDESVAGGEKKKAPKTTVVSIIEEICPCLPICEGEETDSGTKKDEEESKVEQPEDPGAVLNRIHLNAETSKIRTKVTPDYFTVIRIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHI6</accession>
    <name>A0ABY7DHI6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AF10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_006946</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20901">
        <property type="entry name" value="CC_AF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15574">
        <property type="entry name" value="PHD_AF10_AF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049773">
        <property type="entry name" value="AF10-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049781">
        <property type="entry name" value="AF10/AF17_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF90">
        <property type="entry name" value="PROTEIN AF-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="62"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="575"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="575"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="608"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ94475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="691" mass="74613" checksum="4A9899FB5AEFBCCF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHT8</accession>
    <name>A0ABY7DHT8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TICN2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_028962</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF14">
        <property type="entry name" value="BM-40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046998261" evidence="9">
        <location>
            <begin position="20"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="332"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="11">
        <location>
            <begin position="365"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="395"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAQ96272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="435" mass="50641" checksum="0E59E2F4CEC124FF" modified="2025-10-08" version="1">MKSLLLAGLLLVCLVVVTGKKGKDIQDLKNKSVKKIHSNTHDRPGHSRNGRYHKRLRGSHLMLREGGLKSLHNDAWKDLPKKNKDCKTKKCGHKEFCLVNPQNGDEKCISRKQFKKGRRLFTQYHKEKEFLRQDRKHVTVSPVTKGDQLLKEAEHMKDVYDLVHDTKMESHHKHHKHLKNKSERKPELNHIEEGKTNSEECRPSEMYELRERLVGWFVMLHTESRQRHHMKNKDLEKKNPHLSISTHGDVFGAIDKKRANGMLGKDVKKHFLEMETKSKKVKRSTHNAMQIETETHHHCKCSKSAMWEFHKLDEESDHHLTHPELARMESLKREPCLKALFMSCDTDKDGLMSQGEWCCCMANTIPPCAEKKRLTDPAVWDVRCDKEGFFEREQCHEKTGYCWCVDLNGNEIHGTKQHGSAHCGKYDPNGHLFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DM44</accession>
    <name>A0ABY7DM44_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_030361</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Golgi apparatus</location>
            <location evidence="11">Golgi stack membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAQ97671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="457" mass="51688" checksum="CEA6B67D599B5838" modified="2025-10-08" version="1">MAEKTTNRARLSVKILAAYRIKLKSEVHYMSSKIFKENHKSKPSSDNSEKQTVKHHILFAGHMECLEPMQECVWMARVSLQILLTDQLKTAGCLSPTLCRRMSTARNSSLVLVLHESGVTMHEHWSKLWLLRTAECWRWTVLAVTVCWEHMSTNWFPEIKTGHDGPIKPIGEKSKSVTHFSPELQNPLTGILDYVPSLGILSYQQFNWGMQLTGDTLEVCPDVVGTITDPAVIREFRGARKPPATLLHLGALARSNFPTILPPFSVPLQYCLVRIAIAIGFKKNAKLLIIGLDNAGKSTFLDRLADSRLAQNPPTWQTRSKQLDLGRLRFTAYDLGGHPTVRRVWKDYFPAVDGIIFMVDSADSKRFEEAKTELDSVLTCDVLPDVPVAVLFNKIDRKEAVDEDLLTAQLNLHTSKTGKEYTPREKVGRRPVETFPVSLVKLMGYGEAMRWLAYYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DM98</accession>
    <name>A0ABY7DM98_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NETR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_022656</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050912">
        <property type="entry name" value="LOX-like_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45817:SF8">
        <property type="entry name" value="LYSYL OXIDASE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45817">
        <property type="entry name" value="LYSYL OXIDASE-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045740382" evidence="3">
        <location>
            <begin position="24"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="31"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="201"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="304"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="415"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="517"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="239"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ98283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="671" mass="74708" checksum="955BA224BFE9AFDA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DN33</accession>
    <name>A0ABY7DN33_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Novel STAND NTPase 6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057575">
        <property type="entry name" value="nSTAND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25201">
        <property type="entry name" value="nSTAND6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Novel STAND NTPase 6" evidence="1">
        <location>
            <begin position="116"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="246" mass="28058" checksum="952E9A184A9DC0AA" modified="2025-10-08" version="1">MSTLPKTTMEFGMSALEHLKKTLDDEMLQEDTAQMIGLMKSKLGSAYVKMLADSKRPSELLNFLENNMPEDDVMSVAFHVLATMKYHVENKNIAEYIASYQKSRMTCHGRSRAFVVGRDDEIENALSLLQNNKGVLIYGPGGYGKTTFANELCARCAFHNKADTFVVDMRQSRSINDLFKGILEVQNIVLDGDNKELQNEVWYRLKGLQNETLFHLDNMEHVYDAMPNELGQVLGRLEEFNHKVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DR04</accession>
    <name>A0ABY7DR04_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GSTCD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13369">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13369:SF0">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="504" mass="55970" checksum="91940A54EFD8E008" modified="2025-10-08" version="1">MKRFFFDACKRRQDIAAHTVRSGLCCVARYVVQVSHMAAVKKGHTLIDLLGFRAGSVKACAEVSGWTRLCEVELPKAIGGLISTLRKTLLHNDDKKKRQVLKDVQTEAEALISACGKEGGPDIVDEFFQTREAVMPHGSVSLSPNNRVQTKAEKEEKKFDINTENGEVCRYGCTENKLIKWCARCNDREKLKRKEELQQNRNARMNERNCDEKTTIESQEVLKNGLNVNGDTDLGIGSLDELSTFIKTLTIHDVIYEHVYAEGTSFTESMGFGKTQLLDNAPNIKKWLVHVMGLPKIRQTSLQCGYDVSSMEGCLKGEGLQFPTEFSIPPVTLDVEEDNPEIGRGEYRLSPASILVVAMFTWTGQLCPSRPVPNVLPEKRVSRKCEQLENLATAVQSLAKPGDVIVDFCSGACNLDYFQGSFDIGVCLHACGVATDLVLQQCLERGANFVICPCCYGSIHNTHLITYPRSQLFREAGISDYDLIVLGHAGDQTEKATELYDQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DR17</accession>
    <name>A0ABY7DR17_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondria-eating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_023714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031981">
        <property type="entry name" value="MIEAP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16026">
        <property type="entry name" value="MIEAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondria-eating protein C-terminal" evidence="2">
        <location>
            <begin position="258"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ99341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="349" mass="39803" checksum="F5B06B69A5F96C29" modified="2025-10-08" version="1">MGGLQSFPEFPSRTLVEGQSSWYQDFEKYPIGHFLMSMVPPEFYTSFIKQGADHNTHIPYEHRHQQVPRHQEGHQSAHEEERKIRRDNAPPRPQTASPGGRNNELEKLKRENKELQTSLKDVQLVGEDLQREKELLLIRILTRFAIKRLTCATNIVIGIPEITIRSGRVNLNEQSIDVSAKKKHMFSDVLNSATMGAMGLQKRWLPKGGNQPASLSAMQTKLDVKPVNIEDKLKKLRKEVSSSMVPIVQRAYIEAFWNRECIPVLKPFVKACLHLCWKMVVQSPPMRFKLVVTKGQHFDANLYKEYILSGTTIDFVVWPALLLHDGGPLIAKGIAQPVGRNKIESSERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DS01</accession>
    <name>A0ABY7DS01_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PRRT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_023754</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD225/Dispanin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051423">
        <property type="entry name" value="CD225/Dispanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948:SF25">
        <property type="entry name" value="DUF4190 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948">
        <property type="entry name" value="NG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ99381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="172" mass="18812" checksum="858239257A96FFE6" modified="2025-10-08" version="1">MEKADLDDPPPYGTSENDGQQNPGGQQYPEGQQQNPADQQYGQSYPIQQPYEVRAGQQQYVGQPYGGQNMSPVIVTQPGYPEVVTTMPRPPDYMGPSVFACLCCFWPTGICAIYYASQANTAAASGDMAMAKQYSNNARNLMITSIVLGIICIILTIVLRAVIGIKHTYKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DS86</accession>
    <name>A0ABY7DS86_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="160" mass="18583" checksum="20099BC2FFCED59E" modified="2025-10-08" version="1">MHISKDKGQWIFDEPLDQVIERTQSLINALDNVNYIVLVGGFSDLKYLQKRVRRLQNKELLFREVPCCFAIIQLLYKQEYQKQKRFLIGGRAYCDDIFEKHFTFGALLRTPNEECQQIGLLLVEIGKGDNRDFEMNVQLAFGGTAIQVEVRDGHGRFVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSZ2</accession>
    <name>A0ABY7DSZ2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="173" mass="19532" checksum="20656A8B2C4CFF65" modified="2025-10-08" version="1">MWHSKVPSSWKVSVLYNVCPLIWQPLSTSTVRLLMLKQFSLEGPVSVSKNCFLLAADESPCSAHSNLYILNSSSGSTQEVLECVSSKRDIILKVKNKSFRPDFVTTSTAVGEDVVLFETDLNENDDDAFDDDFNQVIQDLDKEKNRIMDFDLPEDFLISDLFESLKIKTVITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUL1</accession>
    <name>A0ABY7DUL1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046801227" evidence="1">
        <location>
            <begin position="22"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="244" mass="27730" checksum="A67D93A391A54444" modified="2025-10-08" version="1">MDYEIVLVLATILLNTNSIGGVGVCNWPALLQDSIWVDSDKGSLDFNTKTMTGLTYVAMGTITIDSWRCYFYNDVDTLIMKADTLVTIFSTFYQPFQCWKMTQITENSYYYYIQSEKQIRINMERITLRDNETITDMTDANVISRLCSDVASVNEYHLLVKDNQEANAAVACPSVFQDDFHYSMAVQNSMGQLEVSQSPNSCTENQTTVDIPKHEDAVCDEKYNKTASNFAFQELLYLSSSRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWJ0</accession>
    <name>A0ABY7DWJ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_025344</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="462"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR00972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="508" mass="56027" checksum="32DD52B5CD76972D" modified="2025-10-08" version="1">MKIRSEEIHPDPACRDSSRSDQDLRYPPPPPLALHPVPGLQMEEDSRSWEERCDRYFSSISDTEKDRGQEKHLPPPTTPEYTPAAGNGHSQQIPGTDRVEDNVQPWSNLSDLKLPLAKNKVLRRVQSGALARVDVHVCNLNLVKKSSIENSPSSSFLEELIGRTNESSRTEQLKRDVKQVLESNGHFSEWIEDDAFIEYLEADVVVQEMQKLSGGSLVRRLAAYQNPGLLRRLGAVATADVQRHGHTASGALLDCWMGNRRCQQTDYSNHVDGTTGGCLTFSILPRTREIVVTMDIQISEYIPDLTTGVGIAVYIHPKDTPPNTGTRIIATHGAQHIIDIQKVKSIIRKQHDCDSGSKTIQESERACLDERVNVACGCQLRGDTDGACDLLSYDTETLFQADMKSDGLFTEADLRSLQDLLGHGRGHSNVSASTVQDNVVRVTLDVSHVVEEVWREDVEMSVLALLSGLGGLSALVAGVSLITVLQVAWLLASSAVRACRKSCCRYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWL7</accession>
    <name>A0ABY7DWL7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABCB9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_007644</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF19">
        <property type="entry name" value="ABC TRANSPORTER B FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002773">
        <property type="entry name" value="ABC_prm/ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="204"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="520"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR01086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="835" mass="93159" checksum="7B55650BC68FB217" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWN8</accession>
    <name>A0ABY7DWN8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tropomyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_024886</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tropomyosin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="249"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR00514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="316" mass="36084" checksum="58872621B82BF853" modified="2025-10-08" version="1">MDAIKKKMQAMKIEKENALDKSEQLEQKLRDVEETKAKIEEELQTLQKKYTNLENEFDQVNEKYNEGTVKLETSEKRVTECEDEIKGYTRRIQLLEDDLDRTQQKLEEATLKLEEATKTADESERARKVLESRSIADDDRIDQLEKTVKDAKYVAEEADRKYDEAARKLAITEVDLERSETRLEAAEAKINELTEELAVVGNNAKALQNAVDQASQREDSYEETIRDLTQRLKDAENRAAEAERVVNKLQKEVDRLEGNARDPRAPPASAPPALAPHDCPQPPREQSSILSGRLQQFCCISAVTACHVLLLVEDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXB2</accession>
    <name>A0ABY7DXB2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OGRL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_008933</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the opioid growth factor receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006757">
        <property type="entry name" value="OGF_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039574">
        <property type="entry name" value="OGFr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015:SF2">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR (OGFR) CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR OGFR ZETA-TYPE OPIOID RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04664">
        <property type="entry name" value="OGFr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Opioid growth factor receptor (OGFr) conserved" evidence="3">
        <location>
            <begin position="87"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR02375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="292" mass="33142" checksum="143271BB26404659" modified="2025-10-08" version="1">MGSVIKPIRHTKSSALRAALTSEKIRKRNERQQPPRNGLSANSSSRNKMQSQVRPETRQRSSANLEFYSNKIQSRPAPGSSPSLTGEAIRNDDRLSRRVLKAYKMMLHFYGMELASELDGSVRRCAENWRHRYRHLNKSKHNYLRITRIIKALGELGLDRYQVPWVRFIIEEAIDHDELPALRGSIYYWIYAIKDPHEKPSSFMLLQGRIVLNNTADETACDWTESEADGESTGKLVTEISTAIGSGQSLDETDRRHWLGRPPQKVASFSDVVTGTVADNNGARNLRTNHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXJ8</accession>
    <name>A0ABY7DXJ8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34967" checksum="2656EC6CE856C13B" modified="2025-10-08" version="1">MKVNYRMRVVAKKLKALDANQTYAICLLDAFHMMKSAWDDVKQSTIVSCYRRAGLVPNLQDESTMIVEDDQDDVIPLTRLAAVMGPVTMDDYINIDKNIPTSENIEDDDIIKELLDLGTADKAKRDRVLPEEGQGAVKGGTGCCQKRDRVLPEEGQSAVKGGTGCCQKRDWVLQKRGKVLPEEGQVLEDTVVVTLLRRGLIFPTINHRLVSCASPTCPQTVVQLALLKQMITIFVSFKTKNNVECDECSVGFGLFLRLPGPLRISHTIHRALIGKLVHEGVILDWNLFESGCMTLHSRVLHQGTDWLQHARMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DY23</accession>
    <name>A0ABY7DY23_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NWD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_008342</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052752">
        <property type="entry name" value="NACHT-WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057588">
        <property type="entry name" value="NWD1/2-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871">
        <property type="entry name" value="BETA TRANSDUCIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871:SF14">
        <property type="entry name" value="DUF4062 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25469">
        <property type="entry name" value="WHD_NWD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="561"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1070"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1650"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1655"/>
            <end position="1673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR01784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1673" mass="190197" checksum="D39C939610BF263D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2A3</accession>
    <name>A0ABY7E2A3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="18020" checksum="843AF3D72DD03310" modified="2025-10-08" version="1" fragment="single">PVHEANDWVNNLVIVEKKDKYLRLRLVDSRDLNKSIKRHHFKIHTLKDVKAQLSGKNILTIIDEKDGYHQVELDKKTKKLISMHFRNVIPKISLDTHFKKKKCQVKSVKYMGTIISEKGMEPAPEKIKSITEMHHQKRRATPTRNGELLTTIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3B6</accession>
    <name>A0ABY7E3B6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate sulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="34065" checksum="CF27F233F29766F7" modified="2025-10-08" version="1" fragment="single">MMLRRVHWWVCRRRGAAIWALMMVIGTWMLIYLTQNRFTFSELTTTPEEKIHQELMPTSSGKKSSILKNTKDLPVEDGFSRAEYLRSACKNNIHRSGNRKVRVSFDPHVNAVYCPLCKIASTFLTRMFRMIALNNRGLPNGTVYTPFDVPISDAPPSTDNLDLNKWTVGNKDATLRQFKSLDAMEAKSSNLHADDAIQDSVSGPYEWRKDIVKCMSWPDALRRIWRKLQIRGVIGTKGFSLSEFEAESISRTDYINVLKKVREKSTANERHMMKQLSYIEAYRNIPEELLDSIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3X9</accession>
    <name>A0ABY7E3X9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NTCP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_009769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF28">
        <property type="entry name" value="P3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR03211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="399" mass="44154" checksum="9B01930A31AB90CB" modified="2025-10-08" version="1">MSSHDFRRSVILEDTSRMNATSTATTPHPSNNAEGPLADSTMTKLQVIMDALLITLTVLLMLSFGCSLHIKHIKDHFSRPIGVVLGVLLHFIVLPYMFYALDQVMMLDRYDEMSLTVLATCPAGGVSNLYVYYADGDLALGVIVTAASTVLGLAFMPLNMWLFSRAWDGGPVLPYIQTFISLVTILVPVATGMIVLRFSQSAAKWVSILGSITATVMIVGTVGLSSYMYPQMYLSSWKTWFIAAAFAPLAFITGYLLSLLMRLPADTRRTMGITTSAKSMALCLTIIAVSFQSSDYIRYLVFPELHSIILMVELALYCLGYRFYRWCNGKYVMSSELPTDVSALDTQLSSSDCEEPTQITTIEDLNVTINRRMSDSHALAASYPPIVTSEYKSELRMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4B6</accession>
    <name>A0ABY7E4B6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">APC7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_010348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF36">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR03790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="359" mass="40615" checksum="0339C33A14A96D36" modified="2025-10-08" version="1">MQYFDYIKQLHDLELYQDLKQLACIVMTLCDSSAETEDLTSDVEVKYKIYECLLYSKQYKEAMSVLEGISTKQRTAKVNLALAKLYIRSGMDRSAITSYKEVLRLSQWIRGHAQVSSNDYVNAVRTFRLDLTDCLKDNVYMVTSIARALFLDGHYKQALTAFQRAHAIDPLHLANMDIYAYLLYKERRGLVLQRLANQLMSATETSPEPWVAMGYLALYTKKNSRAVYYAQKANTLDGMNVEGLLLKATAFLELYGAMIAKEPTAVAKAKPYLEKAMKLDPSNLLPVYVMADILKQEKKFDNGVDLLDPTNELARQGIEQVENGESGAENTFDVEMEHSVSEADFDGSDVESTWSDDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4S1</accession>
    <name>A0ABY7E4S1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMDB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_020384</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680:SF38">
        <property type="entry name" value="BLL1368 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045818941" evidence="3">
        <location>
            <begin position="25"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase N-terminal" evidence="4">
        <location>
            <begin position="41"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR05015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="283" mass="32252" checksum="31165D96392164A9" modified="2025-10-08" version="1">MIYRHTQLMLILLCAAHLYAQIEGENNLKLIISMPPVKTTYPDQYICYAHRLDSVGDIYVLSSKTEADRSAVHHVATGVCEEPMHTDRTWDCTRDQGHLCKGEAVNFGGWDEFTKKNGIFKFPEDVSFRVGNNTKLRYFMIEIHFMDPVQDLKPPVANITLDFVQIPSPLRYQTYSFLNSGVIPAKRKNGYLVEGFLVRNSTWTLIGSQLSMDKEKVVARCLYINNKDEPVKFGMSEEEEMCNFQIDIGFRPQDADHFERPPACSAPSPGFRLCDHPQTSGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6K3</accession>
    <name>A0ABY7E6K3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="4">PARP</shortName>
            <ecNumber evidence="4">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_019946</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="4"/>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd01439">
        <property type="entry name" value="TCCD_inducible_PARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF4">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WWE" evidence="6">
        <location>
            <begin position="58"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="7">
        <location>
            <begin position="164"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR04577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="386" mass="45654" checksum="26166557A138A0B7" modified="2025-10-08" version="1">MFCKPKNEESDIIAWNDFNEEKTTTMSVSFDPVLKGKVYDSEITEAETRRLSTMPYIHGKAKTDSFKTQWRWFWKDNVGRYILFEPDTLQYTIEAKFLAKQKKYLYVKDNNQYRIDFEGMIQRRLYRTTSNRIKRRPIFVSSKDIEEKMFPISLAVQTVNVPRPTSWMPWDLFQPFELVELRNNEKQFTSVAENFYETLDKEQQIIRRIYRVQNWKLWSSLCHHEERMLMSQSDHSSTLDKRNLYHGTDSDDAIRGICTNNFDFRLSGKNATRHGHGVYFASNAKDSHLYTNPPMRYMFQAVVLVGSYTQGKPEYRRPPPKPGGQHELYNSCVDNMDKPRFFVAFEKTQYYPEFLIQYCDKRDIPVTTTTSSPSSDDADPHTCCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7A4</accession>
    <name>A0ABY7E7A4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PCBP3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_021312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd22438">
        <property type="entry name" value="KH-I_PCBP_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02396">
        <property type="entry name" value="KH-I_PCBP_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22439">
        <property type="entry name" value="KH-I_PCBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="97"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="292"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR05943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="503" mass="53054" checksum="EBCDCC6DC61AC607" modified="2025-10-08" version="1">MERTMVQGGETNGIAPSILTVRMIMQGKEVGSIIGKKGDNIKKYREDSGAKINISDGSCPERIVTITGTTDNIHKAFTMICSKFEEDLQNTPTVPKPPVTLRLVVPASQCGSLIGKGGIKIKEIRESTGASIQVASEMLPNSTERAVTVSGTAEAVTACIQVVCNIMLESPPKGATIPYRPKPAVPPVVYAGGQAYIIQNPQIPMPSPAEVWCNCPQEPYGYTLNKLNQMSLGQPVPMVHPQAYMPGMVGHAPAHLMHSNMAEIPVSAAPGYAPIPFHQRPLPNGPIPAPNGQQTHEMNIPNDLIGCIIGRGGQKINEIRQISGANIKISNAEDGIPDRKVTITGTPETIGMAQYLINTSMELHKTLVLDPNSAAPSPSSTVTPSSASPVTPVTSVTSPAVSQQAAPVTMPMTSMNFPGMKPLQIIGMNGLNGLQPLPGSYPSIPSLPGMNGGLNGLNYGLIDPMFINCGIGQPMHHSAANFTGKMRVGVAAVKTGSPKFSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7E6</accession>
    <name>A0ABY7E7E6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="70" mass="7583" checksum="6CC9100CEE8023EF" modified="2025-10-08" version="1">MDMAAEEECTSILDAQEEFIVTFEISLPASPKLLDIVLQLGIRPNFQQVPDHLGPVVLGGCPVPYLTSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8X2</accession>
    <name>A0ABY7E8X2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045661952" evidence="1">
        <location>
            <begin position="19"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="269" mass="29556" checksum="B12A71DCDE0465B6" modified="2025-10-08" version="1">MAIVHIVLVVLCSVLVRGSTLDRIEEELDSRSSKRLDELLENVFERLEKRREPARETIVDLREGGVCHTNGGAAEVLTKPTGPASDEKQCNKQAVLKVAFDKLESCTCCAKFPECGRRMLRIDLELSSGPRSGFMFNIGDSKSNNGYAGDSNDQFNDAELDGSYPNIKAWASDKCKVKPLKTYANALVTNAVSHVTMYVSNEHVRVTNDNGLDEYLCHECLFALNGQPDSSRGGINEDIYVALNRVVAGGRIGVGVCSAKLSWVCPDWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9M0</accession>
    <name>A0ABY7E9M0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15123" checksum="C30AE80363D3BAC3" modified="2025-10-08" version="1">MKGKSFNAVHNWKNISKEEKVHFKDKARKFAVERLAQQEKKAFNLSLAKQQQQHQQSWNEQQPRAPGHPPGPRTQPSINPVIEGSESAMTTEGYHGATSQQLFLNENNCGQQLMVEKFLQLMVSGPIHHTIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EA05</accession>
    <name>A0ABY7EA05_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26778" checksum="3B2082BE144A9B6D" modified="2025-10-08" version="1">MECITCRVKKPINEFPSQTVFNACQHPAFSCLRCIVKSVEDESKCPECPLQVLKNDERVAFFKSQLHYLFKEYSVNSDDGTIVDAIDQDQAIVKSQEYHLYIVLITGKKHKISCDKESTVLSLKSKIKAVTKKNESLQRLFFRNEEMLVKALNNYKNITLSVYEQSSPDMNLCELRLDEVKDWQAVIVCRATRNPKSGSWQVCEMQVPSNGTALEAYGELIKTLSGLLPELKTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECQ2</accession>
    <name>A0ABY7ECQ2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="54" mass="5953" checksum="32796EB6D0C3119A" modified="2025-10-08" version="1">MCIACSGVMSIYLQQSVSCNVPGGCHDSKKYNTNCSKSDKSFHDSIYKQLEKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ED35</accession>
    <name>A0ABY7ED35_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TM181-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_017885</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040416">
        <property type="entry name" value="TMEM181"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054077">
        <property type="entry name" value="TMEM181_GOLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047843">
        <property type="entry name" value="WLS-like_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31918">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31918:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21885">
        <property type="entry name" value="TMEM181_GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06664">
        <property type="entry name" value="WLS-like_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM181 GOLD" evidence="7">
        <location>
            <begin position="110"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless-like transmembrane" evidence="6">
        <location>
            <begin position="240"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR07927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="428" mass="49134" checksum="065E3B895C869BAC" modified="2025-10-08" version="1">MDVTYTFSGKPSGPSWGNGARAFLTQFSDVFSAFGKYIAPSYKHDRCERSVQMRLYSLNKRQFVMVFVTFLMCFGITVLIGIAGPPIIETVSYNLSAMTQGDPNINMKTGPFALKSPPLTTFHQQFWLVAHIITDNTEGTRIEQSFTVSVFIGGIKAEDSSLLQGDNPECRDLILLHLGYLDYTSYVINVNFHGLEQQAHFNIKNIIFYFKSYNTAFTKLEIWLSACFPIRYANSLCEIDPLFPLTFLVNSWIPGMFDAIFQSSFLCGLLLFWLCIYHGVRQTDRRFWKFYSLKVLIVGLIWISAVTLSSWQEYNELQDPTYFYRLDTSNFMGFKIFFFIVGGIYLLYLLYLLVRAITITVLRFGRAALQDNFVAELSTHYQNSAEFVAFYETHFKDNPGLSMLNDSDEEVHYGNHLLKLNDTSEKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EF92</accession>
    <name>A0ABY7EF92_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SNED1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_018493</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0768">Sushi</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="170"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="255"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR08535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="387" mass="41752" checksum="C03BC7E65BD9B08E" modified="2025-10-08" version="1">MAIVSSIYRDRGYAESPIKWLGAGSCWHTSCNGLFRKTLPSCTEPGQRLTDAFESGTEIPHQNTLTLRLEHNLQLEPEQDCYTSASRKLLHCGLCHNTSGLQRYNLNDKSRVGDQSSLIAEVERSKTNCTDSSECATLAYSVCDTIITQKCVCVTSQGFTTNANDDGCDYDCGVLSEPNNGAVSYKSTIQDSVAMYGCHAGFQIDGVTRRTCSVVKPKGWSGVAPSCIAGQLGDLCNTITDLCDNIINGECSVLDIDDCASQPCLNEGTCLEGVAQFACACVQGYSGSLCQDGVGDKAVQTLTIITAISSLVTVVLLTIGGIAIACTRKRGKAVQSHKEQNFMMSSARDSRDIENVSQIMDYEVLGNRDSNNADRRSYQDLHGINKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFA3</accession>
    <name>A0ABY7EFA3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4773 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031941">
        <property type="entry name" value="DUF4773"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299">
        <property type="entry name" value="AGAP008005-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299:SF2">
        <property type="entry name" value="DUF4773 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15998">
        <property type="entry name" value="DUF4773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047037493" description="DUF4773 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4773" evidence="2">
        <location>
            <begin position="106"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="229" mass="26012" checksum="3F932AAC825E4A56" modified="2025-10-08" version="1">MHFLKFLIVIPILICLKPSSIYGEFVKEKLYVEFQQDDELQSGNMDYGTAVNIWRLLNAASMEEDDVASVVDTLESIQLPDDVLNSILDVLPDEVELDLEFLAKGCSHGRCKYCTKDKFLHICIEANYLPHKIGFEIRVTIRGKTIFHKEISVANPPAICINHIPFLSKIANLCIQFYDVSIPKKSACVRAVFYVKLGPLKKKIKLKIACFRIPIAGDEYDIEKSIMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFG2</accession>
    <name>A0ABY7EFG2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase zeta catalytic subunit</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MAR_017509</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">MELC-2E11</strain>
            <tissue evidence="21">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056447">
        <property type="entry name" value="REV3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24065">
        <property type="entry name" value="REV3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DNA polymerase zeta catalytic subunit N-terminal" evidence="20">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="19">
        <location>
            <begin position="74"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="17">
        <location>
            <begin position="3705"/>
            <end position="3941"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="16">
        <location>
            <begin position="4007"/>
            <end position="4458"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="18">
        <location>
            <begin position="4501"/>
            <end position="4571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="566"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="677"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="934"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="973"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1081"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1143"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1225"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1351"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1680"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2005"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2073"/>
            <end position="2104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2170"/>
            <end position="2189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2387"/>
            <end position="2483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2581"/>
            <end position="2620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2638"/>
            <end position="2681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2696"/>
            <end position="2730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2748"/>
            <end position="2776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2875"/>
            <end position="2896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2972"/>
            <end position="3018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="3096"/>
            <end position="3149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="3221"/>
            <end position="3316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="3454"/>
            <end position="3634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="3762"/>
            <end position="3816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="572"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="940"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="987"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1018"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1081"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1157"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1173"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1225"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1262"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1353"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1388"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1445"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1686"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="2078"/>
            <end position="2087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2093"/>
            <end position="2104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="2387"/>
            <end position="2397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="2442"/>
            <end position="2452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="2468"/>
            <end position="2478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="2590"/>
            <end position="2602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2603"/>
            <end position="2620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="2713"/>
            <end position="2726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2748"/>
            <end position="2763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="2875"/>
            <end position="2889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="2996"/>
            <end position="3008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="3109"/>
            <end position="3123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="3139"/>
            <end position="3149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="3254"/>
            <end position="3280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="3466"/>
            <end position="3489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="3505"/>
            <end position="3516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="3517"/>
            <end position="3532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="3615"/>
            <end position="3631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="3764"/>
            <end position="3807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF24065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="WAR07551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="4600" mass="511699" checksum="2FB6EA3CCC6A3A6F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGD4</accession>
    <name>A0ABY7EGD4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BIR7A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_017676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16713">
        <property type="entry name" value="RING-HC_BIRC2_3_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01282">
        <property type="entry name" value="BIR_REPEAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="327"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR07718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="494" mass="55780" checksum="1D6938793285D04A" modified="2025-10-08" version="1">MEGIRENQFDSHGANGNLKSKALSYQGKHIARDTVVDQMKNEWARFGSFYKLQEKMDASFVRLAQSGFFYNGEKDFMQCFSCGVKNNEWPMELTVDEIHKQLQPKCPFMNKLDKSNIPIHHRDCDSETETQKIPEESASGGPDDLVTGPDKHGIPVKDFESINIKQSYDAINIAQAGFPNTSELERGAVDSIYCERRETTLIPQSCAKYPDYDSKTARLATFISWAFSHIITSNLLADAGLFYTGVADCVRCFSCGGGMRNWEAGDDPWIEHARWFPNCEFVQQKKGQSFIDSCRLVGAFGGSDEQEYVVYSNSQDFPQTQTQSNTDCDEDLLKELQDMGFPRSSIDNALNNLRRINSGPVQPDEAVEYLISSAEICSHQPLSEYHSQKSLTPPPEDEDHDEHEHSTKYKTEVLKSEVLLKESEVNPNEVAKKLKYENEQLKQQMMCKVCMDKDACVVFLPCGHLVACVECASVLRKCAICRKVIKGTVRAYMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIS1</accession>
    <name>A0ABY7EIS1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COCA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="23"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="185" mass="20541" checksum="87FE966241665546" modified="2025-10-08" version="1">MDVTFAGAEQAFKAPAAGSETLDLAFLLHYSNSVSREDFQRILDFMKNILQYSDIDDDKLRVGAVVFRKRGIPLFDFNNYYSQEEVFGGIDQINYNYRSKTSSIASGFDTVRTSLFTRTGGEREPAPNLVILITDSNADTDDASELEGHDEQFHNDFVALRAKGFPVVIPALESSTSGTFAVSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELT9</accession>
    <name>A0ABY7ELT9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">HR38-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_035155</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd06969">
        <property type="entry name" value="NR_DBD_NGFI-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003070">
        <property type="entry name" value="NR4A1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085:SF4">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01284">
        <property type="entry name" value="NUCLEARECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="317"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="416"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="164"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR10079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="637" mass="70430" checksum="AFB277E9AA7DC9AD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELZ3</accession>
    <name>A0ABY7ELZ3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035749</name>
        <name evidence="2" type="ORF">MAR_036084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="284" mass="32289" checksum="A1F8F039CC30DB47" modified="2025-10-08" version="1">MSCNYYKKVPTKPPPTSFGFKQVNARELQDILKRVTTPTYSNKLHSEEQRQVNNYDRLLSEGGRRSVASACGRRVASACGPRVASRISSATSGGDSIEGRGRRFTEKEMARLVRRLQRPTTATSYHNRSYYDEDAQQLKEGRIVRARSADIHSTAAKSLVKLRRPTTATLAKTLNTCHLCYEHENKTKPEELDAFDYEYSADKVVPEEEVNFIVGRVSVPTHASSKGEKCQRLPEYIDEVKIRENLPLLSGLRRSKNVQEITERLFPRRKCHGFTAQETTITTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EM09</accession>
    <name>A0ABY7EM09_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HMCN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_036089</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="118"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="391"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR11013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="672" mass="74066" checksum="5368DA7C0B1A8BE5" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQU5</accession>
    <name>A0ABY7EQU5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="86" mass="9717" checksum="CF2B6547A27D6455" modified="2025-10-08" version="1">MYVWSVSEEHFVRVPALFKLYMLVDSIVGIHNQTLLVLQAGSQEFLFEMSPSAVTPLSSLTVKVGESAVFTCRICGRPRPYRHMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ES85</accession>
    <name>A0ABY7ES85_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_026280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF3">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR12100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="498" mass="56580" checksum="04712F919A4B29D0" modified="2025-10-08" version="1">MTSEKQLRLPPDDLKWEKNKSNAWPKLMYEDLVDYLIHAKAYDGKAMKSFRSLYGYNYVQNGWMGDMWSIECEGMTYIKAKISPSQPGVGRKDYNSWIAVSSENTVETGHCSCPAGNARSCSHISAIIYAITLAWANGVGGETCTDKQRAWGKGAAQVLSHDTISDMVFDRPSPFQLQPCTEKTANKTNTDTDCPPRTEQFLDHSDLQDFVSNSTVANIWECKGTMLYKMLHAPEVKRDINEEILQQEHCENASYPVQVPLSCAKCQTFYDKYVNISSEKIQMLAKSTENQNTCVWTDSRKLRLTSSKVNDLPKTKRANPNKFVTNQIYPRFKGCFATRHGQKYEPVARAWYESVSGHKVRKSEIVVSLTGPYIAASPDGIIDERTIVEIKCPTRPLEDLISSGKYDVLLEDGQPKLSPKGKNGYYCQVQVAMFCTESTMCKFVVWTSEKQCVVDVQYSKDFIKGILPRIRDFYFKHLLVRLQASRLKISPEYKSLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESC8</accession>
    <name>A0ABY7ESC8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="73" mass="8303" checksum="4921BEA087F244CE" modified="2025-10-08" version="1">MEDIEKLSACNVLSDCRNHAPLPVITPEVLSGPSHMQQVSRPILVWLQENAKCVVWRDSQRTFVLQFGLNISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESF0</accession>
    <name>A0ABY7ESF0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="16095" checksum="86B507038B50BBC9" modified="2025-10-08" version="1">MKWPILSKKLCLLPEISMLKSYFKSRLKQHRKQVSIEYFVRTSKFGSLSVAQQHDKLTEYSVRSLVDHYQDDMPQPEKFQQELQLWKRTWGNKEEKPGTITETLSETCNFMYPNIIKNPTLMMLTSVTSASVERSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESX8</accession>
    <name>A0ABY7ESX8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045583552" evidence="1">
        <location>
            <begin position="23"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="145" mass="16439" checksum="6462C34B0DC45FEE" modified="2025-10-08" version="1">MDSLKLILYFLVGEFLCVSCSSDTKYYVLPTKYSTEDLMAGTIPCVLGKPLHSDTPDWSGGHNYNVTDRDLFHIVNDIHQEILWTGYRNETNEDGTQGVLYVDNKHPVIVFLPPAALVNQSFPALCERAHSRRVIRSYMSTELDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETG8</accession>
    <name>A0ABY7ETG8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NSUN2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="426" mass="48269" checksum="16FF32C7D9664586" modified="2025-10-08" version="1">MPFNKAGRKRSNAPEEGDHITLENAEQHMSQFISYYKGIGIIPEEEWKPFMESLFEPVPVTFRIGERSRRCINPYDARPNTVSEAEVLRDFLKKEVIPKISNVEIDSEKFRMTALPWYAKEMAWKTNINMNQFITCKELQPLRDFVFAEEKLLTVFKQDITSMIPVCLVDILPEHRHDPDSRVLYHRVFLCGTASELKRQIRRGLELLELNGQLVYITRSMNPVENEAVVAAILNEAPASAAHSITASCVNREDMSMDIDGIVETKPKVEQMDTDGAAADTEPLKMEYRTPLRCDVNVCVAEIEYTEEITDAKLNTSTDVYSTTFDLPDMNISRSDHFDIKRFDATANLLEYNGGKTFPTYVYCSPNVKKLILYNKHAVDHESKNAGGMSLMKGSYTGSSDLYTGMSEAASISSLSLREEIQTHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVQ8</accession>
    <name>A0ABY7EVQ8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="192" mass="21822" checksum="0126653BDB6B5DFD" modified="2025-10-08" version="1">MAANNEKKRNPNFSKEECLLICKLMGEESGHGMSKHALYKKGYTSRITSETKRKMWEAVERSFNVQSTGIHRTVDLLTKKWDNLTQVHRPKFMDYKRQLHLTAKADQMLVSIHSLTYQPVLEADEVPATFHLSRPEASTTSKVFTTSTSCNRCCCQECKAIRQLQKRKLELEACSAWVCGARKGVSSHLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVT8</accession>
    <name>A0ABY7EVT8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="88" mass="10091" checksum="FD1589C6BDBA817D" modified="2025-10-08" version="1">MYDVDVRCVTTIVRPDELFAANGLSKIYVDEQFRMFFSVENNKEILVFKNDDFKNFLFDVAHRLCDVIVAGQNTFGSDWNKGITNSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVX4</accession>
    <name>A0ABY7EVX4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="131" mass="15335" checksum="391BE4BA0AF8A36B" modified="2025-10-08" version="1">MDEGKQKENDFKEQLEKRNALLIRTLEKLATAEDEIQSLEHERQALQEETKILRNSRSRILKGCKTHEKSLSILEKERQQLRDTIVELGNEVEVLNEEIIDLKDYESTIEAAKCANNTAEKKRTQLERKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVZ1</accession>
    <name>A0ABY7EVZ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HS12B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_004225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR14120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="288" mass="32177" checksum="F9B63D492C00DCA9" modified="2025-10-08" version="1">MVIADAQGKTMPANTVFAAAMRHLKNHFMEQAQERVELEKHEVRWVITVPAIWNDAAKQVMIEAAKLAGTRKDKLTLAYEPEAAAIYCKQIRLANLREQGKDATIQPFPPGFKFLVLDLGVSFYNFKSPIDDFAKSNLKIVSLGGTVDITAHEVQRDGTLQALIEPSGGEWGGTLVDDGFLRIFEGLFGTDFMTDLKTNIKIADSKRELDAEIEIKKKTIVGKRHKNFKAEGVITFRLPHAMKKAKKSAQLKSALASEHFMGKLSLKRIKFGFTIPSCCLPLKIQFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZ42</accession>
    <name>A0ABY7EZ42_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="10"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="199" mass="22675" checksum="385FF654F688F611" modified="2025-10-08" version="1">MEGLQFFGSLDFLSGITNWEGFSLTHVIQNDINDLYKPQPLSETIDNWLTPLLIKSLFPKEIQQLVLNRYTNWDDPFSPEIVREQILQLLGNVSYNVSNIRAALLHFKHEYDTGSGNYLYHFVAEPPNHAVETPSLINGATHADDLLGLVEIDNFDNYTDLQRSVGLHNDVLGEPCKNRVRIVTFILNMVHVVVLNQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0T7</accession>
    <name>A0ABY7F0T7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM121 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026624">
        <property type="entry name" value="CECR6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032776">
        <property type="entry name" value="CECR6/TMEM121"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47399">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47399:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14997">
        <property type="entry name" value="CECR6_TMEM121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR14363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="304" mass="34147" checksum="2061B6EA7951501F" modified="2025-10-08" version="1">MTAMHNPRLQLAKTVRCLHHWPTRTLCLFLILIQAASLNWYLMDNLSFTWAAVYAADAVVITLFIASFFMATSNIHHEKHSNDPPFASASHLPLSYISWFAYAVLLDIKVVMVFTKFSTDLDEDSFFGPNTMKTSLALAGLVFLTFLPTQHDATAGHRRQIITTLTATVIFDILDGVDNLENLFDKDVRDSYPPGLDDAIIGICCVNFLLPTVPLFTLAKTRFGLTKLPERLEILHKVAIAYLVNLPLFITRMVTWHGLSAGISIFLLKNVIAIGVVTFDLVEHFCCKAPKRDSDNELDRYRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F131</accession>
    <name>A0ABY7F131_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CCKAR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_005164</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF47">
        <property type="entry name" value="ECDYSTEROIDS_DOPAMINE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="23"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="304"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR15059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="429" mass="48240" checksum="923535AB26EDD836" modified="2025-10-08" version="1" fragment="single">MEDPAVVTVMAMLSMFSICGTIGNSLVIYIFSHKKEKSTAGIFIMCLAGTDLFTCVFVMPFTEVVVYLNYMVSYDVACKVYMFLITCNVPFAAFIMVAIAIDRYFCICHPFLHVLNIFRAKVIVLCLLIVASTFGIITSLSYGVYSYELVVPENEALASTNETKTVLYGQNATLNTADHGMCSNCSNELWELDVGDLHVFGKNKTDMQAGFELNYTGLCAPNHILTGPKFLNIYQRAYAGTYLLSFIVVFVLYGLIYRSIHKYRAKRSRRKRSSLYPSGVSHVTSLLPPCIESMKAETQLTAATHVNPHSGRRSDPNLKNGDDNVDFQTPTEMQPRRPKPRNVTRAISIKEKTLLANIRTAVMLFVVTVVFLVAFLPAWLMGLQAIEFNAVIFYMYFVYHTANPFIYAFMNKSFRDDLGKVLKCQSIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1F5</accession>
    <name>A0ABY7F1F5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_030621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR16027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37336" checksum="01DC6F3324CF066A" modified="2025-10-08" version="1">MADVIGKKVAVILGVVLSLGVIVLTVVLCGAFFFFRPSSGQTGNQQLKQGSKNDSHIQNTTSGPIAVDTTQSVVGHVTFPLLTETSGICASRRYKDVLYTHNDSGGLNRIFALNGTSGDHLLTIYIEGATHQDWEDIAYGPCGTSSSAGGYCIFVADTGGNAGGLANTIFRIAEPQVDFSLNIGSELNVPLDSTLKFSWDQYDCETIMVDEQGEVYVISKVMSWNQPKLAHLPRHAWGTNQRVNVSMGVFLPELTSNRDNPTAGDISPDGTEVLLKTYQQVLYWHVPDRDYFRHMARRPAVLLYIRERQGEAVCWDAASTGYYTLGEDVNATLYYYRRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F293</accession>
    <name>A0ABY7F293_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="197" mass="22329" checksum="B2F89DA11CF1F241" modified="2025-10-08" version="1">MWHRPITPHSQTEQESARYYGQVCHIQSTRTLLQISCFCKDKGYKNIFVNEDLTRERSRLLFLARQQVKSKRIFSTWTHDGTILIKMPGSSLVHRLTKPTKRHVSSPEQHADLKRNRLGSDVSVGWDDSVRVQLSDNNIESLASLLRSQPPANPVLSDDQLKQLASSLADGVASKFGEKIKSFENENQQITPKGSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2A4</accession>
    <name>A0ABY7F2A4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34305">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34305:SF1">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="244" mass="28501" checksum="F070B52C8CD85594" modified="2025-10-08" version="1">MIYAPEDATFQFGTYNPEKLGRAYYFNEHGVKLRNVRKFQIDEDRAGRNNDHDDEAMDFERCRKIYSKIQQSAPGTSNLFLWFCPDHGHCYGFHMTVAEGRKDPSASLYSHLAKPPQAVFYDFACNLQEYCLNRESGYYKNVRFFHDIFHGYSHKCSTSFRSSRLQGFESVNSEICEQFNSFIQILKKSARQMTQSHFCFYLQFFIHDLSEQTPTLASSFAVEKGQQVPPEVPPEIHHVFDFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2C7</accession>
    <name>A0ABY7F2C7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="120" mass="13788" checksum="5444EC93905002D4" modified="2025-10-08" version="1">MDLSCDMLNVTVGLEQLIYGERIVQSIHEIKLEVLCFIRLDVSRILCSAGAIARLSSKNMQEISSATNENTRKKGDRKIGDMFPETRKLLRDFYNSHNNKLGRLLGQQFNYNRDEQGMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F354</accession>
    <name>A0ABY7F354_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_030418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR15824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="568" mass="63194" checksum="740EC0230C6E673A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3P0</accession>
    <name>A0ABY7F3P0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="454" mass="51367" checksum="42C552F23F5767A0" modified="2025-10-08" version="1">MDIRREVKADQALVDDDLLHMIENWRGQLTAVRLRRGVDSSSSDTEDENSDFDESKRRSDDSDDSDDDSDGNDDSNDFNKRKRRPNKSNDSDDDSDDDSDDDSDDSNDDSDDSIDLNKRKRRPNKSNDSDDNSDDSDDGSDDSNDLNKRKRRPNKSNNSDDDSDDDSNDASDDSDDDSDDSNDFNKRKRRPNKSNDSDDDSDDDSDDDSDDSIDLNKRKRRPNKSNDSDDDSDDDSNDASDDSNDLNKRKRRPNKSNNSDDDSDDDSDDDSENAKTPKRRPNKSNNSDDDSDYDSNDDSDDSDDDSDDSNDLNKRKRRPNKSNDSDDDSDDDSDNDSDDFNDLNKTKRRPNKSNDSDDDSDDDSDDDSNDSDDDSDDSNDLNKRKRRPNKSNDSDDDSDDDSDDESGDDTDDDSNTDDSSDSDDRKRRSNDSNNSEDDSYDDTDEASDTKDSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7C0</accession>
    <name>A0ABY7F7C0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NR1H4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_031280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF506">
        <property type="entry name" value="NR LBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="9">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="10">
        <location>
            <begin position="127"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR16686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="344" mass="39824" checksum="0DC847EF58A936E8" modified="2025-10-08" version="1">MSTKGQKAKTHYTTVEMAHCRVCGRKSSGYHFGVVSCEACKNSRISTVCRKGNNRCYGDVRSISDCSACRLNKCKDLGMSKRMPIDLSVRSPHVDVEDLEVCETIQRLVNLQDSLYPHAANDPSVLLELAIIEEEHRQREEVFKMMFALRKKGIENEKNIVKYIQHSKHIPGFDTLELDDILNLLKDSYFEFWLFSNHAYFNDQVSGGSDAVVQAHKKVIMSLFPKDYVESVFKFAESLRSLELTLEEVAIIRGIILTFTDRQKLNHSHAVEKLQEKYVECLIHHLSTTRDQYLSRFCRIIDRLTEVRSLTYRNSFVNSQVLSDWPFIAKEFPLWKEIMSTHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F871</accession>
    <name>A0ABY7F871_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="358" mass="39860" checksum="04E1A5ED3890C859" modified="2025-10-08" version="1">MTRKSQFDFIVNRIKREPDNESSESEDSTESEETEDNDSSDSDDSTQSEETEEEGSDRKKRSESSTESEDSTESEETEDNDSSDSDDSTQSEETEEEGSDRKKRSESSTESEDSTESEETEDNDSSDSDDSTQSEETEEEGSDRKKRSESSTESEDSTESEETEDNESSDSSDSTQSEETEEEGSDRKKRSESSTESEDSTESEETEDNESSDSGDSTQSEETEEEGSDRKKRSESSTESEDSTESEETEDNESSDSGDSTQSEETEEEGSDRKKRSESSTESEDSTESEKTEDNDSSDSDGSTQSEETEEEGSDRKKRSESSTESEDSTESEETEDNDSSDSDGSTQSEETEEEQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9A9</accession>
    <name>A0ABY7F9A9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGRB2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_031968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF48">
        <property type="entry name" value="THROMBOSPONDIN TYPE 1 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR17374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="472" mass="53335" checksum="A978DBC3200DDF88" modified="2025-10-08" version="1" fragment="single">LSETRTTACFNIWKECKRLNWIKFKRSNYFSFDKRLDTIEGEFGSLTDRVSKLELLVNTSENNSLQTDSNGSGTGHTLDTTYTKPEIIDIKNTLTEFKRSFAKQKKELLDVNYNVKDTFSVFLTNASSTVNTLVNIVSDYVHNSAENVSAALVKVNNTLVESGRLLRSDIITYLGNISSEVKIDMVIRFEKQKQEINKKSLDLTSKVLDHIANGTESLNIFKRNILQDAYETRANVQNETMKMEKKVDELIGKANEVVGIIDEQRSTIEDRIMVTIRTLHSSWNDWSAWSDCSQSCGRGSRSRHRNCDVTPPFTDDICIGNDKEIEECVIHGFCPYWSEWSPWSQCSQTCDTGTITRDRACIAPDLITSTCPGNRTESQTCLTSAECPSRLISQWVKRVYSSSPSSSDASQIVGEPDVSFETKVNVTSIEIYETYDGGYVTGIKCYQEGAYHSLYVGRENHQHVARIFSPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9W1</accession>
    <name>A0ABY7F9W1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR18134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="104" mass="12175" checksum="5FD4192D3DEEEB6C" modified="2025-10-08" version="1">MNGHQFTDEIGPDGDALLYDLLSVTEYLPFCVLTDWPVVRSPPTVNSELVSAISAYNIPEQKKRKKKKKKKKKKKKKKKKKKKKKKKKKKKIDDTDRTEKDILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAQ0</accession>
    <name>A0ABY7FAQ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NPSR1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_030985</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="89"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR16391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="375" mass="42560" checksum="867EABE0F4809078" modified="2025-10-08" version="1">MDLFGNISFEYLMSNASDSHWPCGWLDEGVSLSNNSTNFTTNACLEAAFSNFKVGGRARSKLESSSLMNAGLNIFTYVTPVVLVIGLVGNGLSIAVFRTSTMRKMSASVYLAALAMADICTLLVYVLVEWLRRGLPYLAPGLSVSLLDINGICQVLLYFAYVARFMSSWIIVTFTAERFSGVCFPLQTMHRKSKRILVCLLLTGAIFVIYKPFLSGEYKIGERTLCTSNPEHIFVSFVLDTIFVTIIFFLPLAIITTLNLLIVRTLYLRNRHTNDLFAENTKIRLEFTLILFAISFFYITFHMPFFVLWCKLQIINGPHLPSVPRDKHFWDYWIGLLNIARTVFYLNYCSNFFLYLFPERTKEAVLSSQANTSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCY6</accession>
    <name>A0ABY7FCY6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_000867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052729">
        <property type="entry name" value="Acyl/Acetyltrans_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47237">
        <property type="entry name" value="SLL0310 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47237:SF1">
        <property type="entry name" value="SLL0310 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="495"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="777" mass="87571" checksum="1E5C36B59506C6B0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHT2</accession>
    <name>A0ABY7FHT2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">STAR9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_002272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF1">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="102"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR20434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="142" mass="15306" checksum="C9B454516BA9CC21" modified="2025-10-08" version="1" fragment="single">MSNIRVAVRVRPLSNKEQEDGSQEIVQVKENVVRIENIKVRGVPEFGDTARARARDFTFDHVYDSVQGNAPCASQAQVFNDLGAQVLHNAFGGFNACVFAYGQTGSGKTHTMMGYPASSQSSLNEAGTGTSILCDTVTNFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FI40</accession>
    <name>A0ABY7FI40_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cilia- and flagella-associated protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_015216</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CFAP43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25828">
        <property type="entry name" value="CC_Cfap43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="406"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="621"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="759"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1018"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1168"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR21242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1276" mass="147170" checksum="2735F8F98E9E381F" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJ80</accession>
    <name>A0ABY7FJ80_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="145" mass="17486" checksum="01105544E18E357B" modified="2025-10-08" version="1">MVGTSKERVANWRKLMKEDPIKYAQYKLKEHERYLKKKERGVVKSIDNMTPREQNKTRRAWRKSQRARTKRIKDMNAMMTPPTSPDENRFQQNSRREAAQRNGRRKQLRDRAKAYRRILKLTTQEVIKGEIQEEKPKIKGEECDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJI9</accession>
    <name>A0ABY7FJI9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_016219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056564">
        <property type="entry name" value="Ig-like_KY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053041">
        <property type="entry name" value="Transglut-like_Superfamily_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020:SF1">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23265">
        <property type="entry name" value="Ig-like_KY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="2">
        <location>
            <begin position="234"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR22245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="788" mass="88478" checksum="FD85320E1FF5BBC2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJU7</accession>
    <name>A0ABY7FJU7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="226" mass="25254" checksum="3A88D3C59D95B725" modified="2025-10-08" version="1">MRPTNLKVTFQRRGGQEDCSGYADRVSDVRIHLTNGVTGDHLPERHMQERHYQRDHRQSRDEMSNQQRASQLLREAAALLHEQQASTAPGQNTETVTAGTEKGLVKEAGSSGGPKSFPTIMEEKLSELKGKKEEFTIRVVRRLFHATAIDQLDLKLHGVLEALKASSSDAEAILGISSSNTSADTVVDLFSPSYSADKEEKENEEMIIYNFSNFLKKFCITGVEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPK1</accession>
    <name>A0ABY7FPK1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZYG11-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_037807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056845">
        <property type="entry name" value="LRR_Zer-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055142">
        <property type="entry name" value="ZER1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF22">
        <property type="entry name" value="ZYG-11 FAMILY MEMBER B, CELL CYCLE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25013">
        <property type="entry name" value="LRR_Zer-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22964">
        <property type="entry name" value="ZER1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Zer-1-like leucine-rich repeats region" evidence="3">
        <location>
            <begin position="191"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Protein zer-1 homolog-like C-terminal" evidence="2">
        <location>
            <begin position="337"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR24138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="544" mass="61472" checksum="93FD2DCBA797A464" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQ65</accession>
    <name>A0ABY7FQ65_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ENOF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_036973</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR23304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="112" mass="12764" checksum="2AC5F450CA8A4537" modified="2025-10-08" version="1" fragment="single">VQKKKKKKKKKKKKKKKKKKKTDKLICVDANQVWGVQDAIDWMTALAPYKPLWIEEPTSPDDILGHAAIAKALNPLGIGVATGEMCQNRVMFKQFLQANALQFWKMRADLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQR1</accession>
    <name>A0ABY7FQR1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="386"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="679" mass="76110" checksum="69F445EEE1A1C4ED" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSQ8</accession>
    <name>A0ABY7FSQ8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_010896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF3">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="461"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="579"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR25192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="611" mass="68732" checksum="4C137D5AA758BCF8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSW1</accession>
    <name>A0ABY7FSW1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LRP4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_016275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="1">
        <location>
            <begin position="46"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR22301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="578" mass="63651" checksum="C8F0D7B77FDF57E2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FU96</accession>
    <name>A0ABY7FU96_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylinositol-glycan biosynthesis class W protein</fullName>
            <ecNumber evidence="5">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_038082</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIGW family.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR24413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="481" mass="54041" checksum="7E11CD429A9D818B" modified="2025-10-08" version="1">MHDMQLSVKILQWKWYHLSATSVESTGSGSMSAVYRSSDSYLRSSMLSVLMDFFLVILPVELMLTGLSDFGPHCLFAMVLSLWILINIQLSKPKIKKAKTNLAVSEIPMGNRRPFITYYRAYANLITAVSILAVDFKIYPRVFAKTETFGTSVMDVGVGGFLIANAIVSPEARGMVSSDSILSSIWKSIKSSLPLVVIGMVRVVAVKALGYQEVVTEYGVHWNFFFTLAAVKIGCTLLFCSISPRLWSIVGVLTIALYQHSLTYDGLKEYIIKGADGKGGRTDIIDANREGLFSCLGFFSIYIMGVQLGKIIMRKREKVIDWIKLCITLVVMSTAFLVMMYYCGKHVEKVSRRFANLAYLLWVVAFNSLLMLAFLMFDIALFILNHVTRLSRKQESPDGKDTAEVAPISEGYRTCDLISAISYNGLFYFMFANLLTGLVNMSMKTIYQSNVVAYLVVTFYMLILSVVSTLLYKRKLCLKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVF1</accession>
    <name>A0ABY7FVF1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_011912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="129" mass="14821" checksum="4CB11EE79059AAE6" modified="2025-10-08" version="1">MTDSYLVPRPRTTEMTFWSRYDPVAQPRRSTDHWTKMKQRAIQYRSLDNPDGIGAPMSMDALQGAMPGSYMYTRPRNSVSRESTRSAFNQRARDGFRYWLIERPKPTSFGKYGIGSYKTVLGVGNAPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVI5</accession>
    <name>A0ABY7FVI5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_011326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR25622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="93" mass="10717" checksum="C0D41F7D2E256F3A" modified="2025-10-08" version="1" fragment="single">MIPSKETLSCSVHTCDIGTTLSITLWQIVLEKKWGQCEQRLTVRRHDSSIIYDWQCQNNTATPQLLNTTEQYLIIRLENNLTSNLGSFWLGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVJ3</accession>
    <name>A0ABY7FVJ3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TLR1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042342">
        <property type="entry name" value="TTC22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16253">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16253:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="15"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="275" mass="31219" checksum="AB6F5D1C4B25F502" modified="2025-10-08" version="1" fragment="single">MESTLSHIPDLPPDKDFHLFVCYIRENLHDVHTIVANLERAGLQCCYHERDFTPGSSILDNMMYTISRSLHMLVVLSEDFVNSPYAVHELNEALHIRISEGYSIIPIKIEPCQVPDAMKHITWIDAENDDVNDMHHKILDALLKTANNGQSLLFKLMPFAGCLSFTRYGLLSTQNLDTLEELVTKSAFVRYRHVFKRFKFITFIVYILMSLLSMFVGSIFTTVAAARGTQHSSDHSTDAFLGCAFWILMTSIVPLACCCADCLSCFQLMKGLRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FX17</accession>
    <name>A0ABY7FX17_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046565742" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="32"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR26192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="141" mass="15534" checksum="09AFFB536BA0DFE8" modified="2025-10-08" version="1">MMDSEKAVFHMVVLFMNVLTSICRGEQIRLSPEVSELVIAEGNRLQLDCIHDNNKNAQSAYFTKNGEIVTLDNDDDYMITSKSRMINATIGTRQTIKTLVKDSTAPTDNGVFACKSGNIEASINVIVFKDGHFTSTAAVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXC5</accession>
    <name>A0ABY7FXC5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IGDC4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_011090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059177">
        <property type="entry name" value="GH29D-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13290">
        <property type="entry name" value="CHB_HEX_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1582"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1676"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1913"/>
            <end position="2011"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="2142"/>
            <end position="2250"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="2504"/>
            <end position="2597"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="2704"/>
            <end position="2796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1097"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1182"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1242"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1375"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1111"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1129"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1250"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1290"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1335"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1375"/>
            <end position="1387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR25386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="3370" mass="379235" checksum="49F1C69A6CD6F6E8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYN6</accession>
    <name>A0ABY7FYN6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_012779</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR27075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="230"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR27075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="485" mass="53079" checksum="574EC5F12ADDA124" modified="2025-10-08" version="1">MTFLLFLNLLWRKPQQFRHAVTVLRQQGGAINPSFSDCPISLKNNSRKTHHYDFAVSVICEQSGALNPSLINIPSVWKKNNAKRTSQEDVVLSLEELAGRIADIDKRRAREILENAVQRIIELLTVEKPFAVSEKASIGQIDSIVELANENTETDSPIILVNELETSESTASNQEDIVAWEEPLTQDQDKIVSVNPEQNSAAISDVAFSTTPNLRTAKPHGLVFTMVTRGSKQPKQKTGNQSDENMEPTILGPVRKRGRGRPTKGTIPPPVVNDQGQNYTCDVIPDSGHLRVIFVGKHSQPRETCRPTLHVLTQTRNRGRAQPSLQRHEAMHIKAEYSCDLCGDAFTQPDDLQNHLLTVHTTVAQPLVCENCNFVFEDQSEWAEHRQLHENDSGALGGTPVQVEGGDTVYLTSGEGLHTSGGGDQVLLVEEGVGIGGGGYDALHSVLVSAAMSVDTLGEGGTQFVHVLCVDPETAQISNTDQTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYT9</accession>
    <name>A0ABY7FYT9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32255" checksum="D0217A89C1A7D7AB" modified="2025-10-08" version="1">MTKAKYTSSDVQNEIITICSQQRLIRIYGNMFECWSKYNNDECQDCTSNEQLSLCISYVTTQCDRNAIRVDFIGFITCKSINGGAIAESLMIQLEECDLMIVRDQCYDGASDMAGNFNRIKQRVPVAHCIASLILAVVHRSKSQCVRTLISSVQDITFVSSKLTCAAWSLRSYLPTYTTKPIDIKNTSVREMLCKCDTRWTARSDALSTFRNVFSVVIRSLEELQDDHGRAPHFLTAILRFDFIITLVATQYTLSAPDGLVKIVQMSKNDTLLFIILDYVNIVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0R6</accession>
    <name>A0ABY7G0R6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="190" mass="21688" checksum="E19686F2DACC9A5E" modified="2025-10-08" version="1" fragment="single">MVSEAWQPFPKRWYNEGLLVTTTKPKDDSQTQTGNSEGQGAGASSQGQISKLQGRSRGGGADDREGFLIHPTRGRITTYIFYVPIYFRKKHNVHMYFDKDTGSWMRIPIVWELHHSMVKSLVDQVNESVPTWSDRNDILSLLRACDYDPDECISIYLNLQKDSEVDERPKYGGVRDGGRGDGTRMIWLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3L8</accession>
    <name>A0ABY7G3L8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BLI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_002611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="5">
        <location>
            <begin position="62"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR29043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="312" mass="33170" checksum="A6EFC9ACD9D4490A" modified="2025-10-08" version="1">MYLRHMPNIFLFVQRMSMRIETGHYLMLHGGSNKASKTSAKHIGDGLKMDPRNRDACVDLYDNDQNPLPSVGQNHGTKCAGVAVASKNSICAIGSAFEARYAAIRMIGPFGVTQSAKLQAILRAGVDVSSNSWGGLDGTFDGPSANEQNAFIKGSKLRGGKGVIYVFAGGNGGFDDNCNLDGYVNSIYTIGINGVARDREPPGYAEPCSAILASAYTGKGGSSDNVCTTDVNGGCISSFTGTSAAAPLAAGALALVLESKRWLLNYHNHTNSNNIANTIRNCIIKNISYVEYNTEKRSKKKLKLNASELIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4K9</accession>
    <name>A0ABY7G4K9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein KTI12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_002951</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR29383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="176" mass="20188" checksum="08EFA8A16E1107CE" modified="2025-10-08" version="1">MPDDEIFCDTNRDVASEWNMARPDEERYSQDIFDGLVQRFEEPKANNRWDSPLFVVQKDDALPFEAIVDALLRRKAPPPNASTLPQPLSSTNFLYELDKTTQDILGVIMESQKTSVPGDNIGIPGATDKLQFTRSFTLAELQRTRRQFITYMKMHPVDNPGKISNMFVQYLNNTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6D1</accession>
    <name>A0ABY7G6D1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FGL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_003548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF6">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046840908" evidence="7">
        <location>
            <begin position="25"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="8">
        <location>
            <begin position="64"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR29980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="267" mass="30406" checksum="6F08E42128A48058" modified="2025-10-08" version="1">MLVRPSMILLRPFAIAALVILATCEEDRLRKLEGQMIEMKAFQSYVMAFTVPGVTGLHGPIVTRAAEVDKADCSDVLKLGLSRGSGVYKITPWNTHKEVEVYCDMDTEGGGWTVFQRRYDGSVAFNRSFVDYERGFGSLDGEFWTGLGLLYTLTSRANMTLRIDMSLPDGTTGFDEYSGFYISPPDRYNFNVDRRMNSERMTNSYLLSDNSSRWDINHQPFSTYDRDVDNWFGNNCALRHGGGWWFNECMTNNLNGPYNSDVQDRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7Z2</accession>
    <name>A0ABY7G7Z2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="181" mass="17709" checksum="29AEEA394F7A0EC3" modified="2025-10-08" version="1">MQPDIMLVGINDGPENTAESTLASAETTTETASTILSTASVVGHGRHPVAIVTVPRANTAVNDGPKNTAESTLASAKTTTETASTILSTASVVGHGRHPVAIVTVPRANTAVFVFILIINVLFGSLGGGGGIGIGGRGNNGGSNYGSGGSHGGSNYGSGGSHGGSSYGGSGGSGVVDEYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9D7</accession>
    <name>A0ABY7G9D7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR30149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="352" mass="40585" checksum="B049E561E87EB5C4" modified="2025-10-08" version="1" fragment="single">IPCRRKEQIIGVGKSDQFPARLVDDIENEQSSETPNEETIKKGTEADDGFRKRKRVRSEHSSNYPIQSRHGDRWHALIVILLIHSTLSPASGQVIDRKTGIVNNVTGCLVEVDVKSEVNLRWTTLETNPLMDAIIDGKLIANYDLRHLTVNTTNMNSSETSPHKANLEIMIFVILLQLVSMVMAILPERMIDVYQTDQLMLLQLVSMANAILPERMIDIYQTDQLMLLQLVSMANAILPERMIDIYQTDQLMLLQLVSMAMAILPERMIDVYQMDQLMLLQLVSMAMAILPERMIDVYQTDQLMLLQLVSMAMAILPERMIDVYQMEQLMVDYNYRYSIYINRNLKKYMRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9T2</accession>
    <name>A0ABY7G9T2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_033219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046094110" description="NADH dehydrogenase subunit 6" evidence="2">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR30677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8146" checksum="F42A119023D789EC" modified="2025-10-08" version="1">MNVSLFVCLSVACMLGLVLAQTGGYGSYGYGYPSAGGSSSNMWIYGAFLVLVLLLVLLQPTSVPLTVNNQSVGVNVLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GA47</accession>
    <name>A0ABY7GA47_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1082" mass="122741" checksum="DA1BDA1C0E86FC63" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GB48</accession>
    <name>A0ABY7GB48_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="78" mass="8615" checksum="B4A45A41430E2F0B" modified="2025-10-08" version="1">MSTSSFSTSFQNKINELEKKLIAENKSRERDRGRPSIEQPARRPKPCALSVPVDLGGGSRSSSAPSSGWKLNKSIRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GEJ9</accession>
    <name>A0ABY7GEJ9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="302" mass="34269" checksum="0A8BFD69C3F9AD3D" modified="2025-10-08" version="1">MRNDKHEGVPAITVVCDDGWSKCTLKHTYNALGGVAVMIGSESKILLHIGIRKKQCIICSAAANKNVAPKKHDCYRNKSSTSQSMESDIILEGRERTWVRYMRMIADGDSSVNLKIVECVPKNLVIKGKEKLNSKYIVRITTAIRCAIRMRSQEQNAKQLKQDITNSSFHQHDFWKEPSENDMESARVAAKLAFKIDDLKFIIRDVSVNIKNIGAEKNDRLIGNLTTNLAENWMAIRAKFDGGKQIYRCQRCSWGLWGALRKPLGPAWSPMVFQEVTGCEPGSYFFNNARHPEKKISFMQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GF01</accession>
    <name>A0ABY7GF01_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MENG-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF93">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE TMT1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="96"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="331" mass="37761" checksum="84FF631C47238D45" modified="2025-10-08" version="1">MDGIPTTSLYPKYYRNFRTTVLSEIFQTLRSRKYYAMCRGGSRNRAIPRSTMSAFEDYDVVSRNYDANRGPIGLETVSAFIQFYTNKPLQELHVFDAGCGTGNYTKALLELGVGQVTMVDASPGMIMKAKEKLNDEFEKGRVKFVENLLPSLPFPDDTFDVVMFNMVLHHLDKHRENNTDEYPNITTAMKEASRVLRKGGVVSITTTLRGQFQKGVWNYQLHEEITLIYAPILQTSDFNKKAFAEAGIDMKQKLSLLDVPLVTNHDFYEGPLHKEWRDSDSYWSYATEAEVDEVKKRIWAMKKAGTLEEWCKEHDKTSTNGAITVIIGTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D933</accession>
    <name>A0ABY7D933_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.10">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051549">
        <property type="entry name" value="PEP_Utilizing_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43615">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43615:SF1">
        <property type="entry name" value="PPDK_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEP-utilising enzyme mobile" evidence="1">
        <location>
            <begin position="284"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="367" mass="40928" checksum="F0847302FA3AAB3B" modified="2025-10-08" version="1">MMPGCVTPLTSSIFGRAVDRACSVVGSDFGGSQTMTNASKLTISNCGRLFINLTYTAHIYSNSVIYKKEALEMNLVGTTLEDHTLEIIESQGRVCGSFMKKLMNAVNFFSVSSHKIKIANGWLDKLKGYQVGERCKRSAELYKAITEQLPDYYEEIASCIVDCKLVKEFLEISESVILKSNAYLDIRTEGPSIEEAVNRLKSPVSWFGCFLLKKWIVKKARDAVGNREFGKSIAVELSDRFKQAYWRLADMLFMEIQVQEEEERKPTFTLKGKSQLCNKMKKIKGDVLIVSYTDVGWSPYFPLIAGLATELGGLVSHGAVVAREYGLPCVVNVPDATHAFHSGDYVHLDGTNGAIHSVIHRLEQLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D9V7</accession>
    <name>A0ABY7D9V7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ93587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="126" mass="13649" checksum="8AE9B165155EC136" modified="2025-10-08" version="1">MAKVSSAGTVLLTIALRTEWKLQGHQKGVQLWTGMSGTKVYFETLEVTEKTYISHTSTVRGCSSECKSRDDFKNCTMLQRTLSGCVRKDCCSDTDLCNSAEIVGMGVPLSVTIIACVMMCVAVPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFU7</accession>
    <name>A0ABY7DFU7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_029259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="679"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="785"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="910"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1259"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="572"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="680"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="819"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="842"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="858"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="952"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1051"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1122"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1150"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ96569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1283" mass="142082" checksum="B4B2259309761781" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGY6</accession>
    <name>A0ABY7DGY6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_006736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ94265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="540" mass="60098" checksum="741A7C6BC81314DB" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHZ8</accession>
    <name>A0ABY7DHZ8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_029020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="133"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ96330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="290" mass="33375" checksum="E1B06CC451938BBB" modified="2025-10-08" version="1" fragment="single">MDPGSSSISKGSDLIHDYSCSKCEESDLNTEAQLFCPECEHYLCDKCVRIHGEYFKKHVVYGRGDIQKWERFSMDRCDQHGYKLEVHCDDHQELCCHTCVALNHRLCSSISHLPELARGFLEKAEFKQLPEAVDKMRSRLDELKNAAKMKDQASLKDSYKNILAEIKALRKEFDQILDKLEQKTVEQLDSMMTDSENGLKNDIETCSHMSDLLKTMMDKLKQITGKNQETNCYVGHRKCQTKLIEAKNLVHEIQGKPEEALCFTSDSSIMPFFRNLHMFGTTERVSSMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DI53</accession>
    <name>A0ABY7DI53_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CP4V2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_028448</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ95758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="463" mass="53323" checksum="B4622C258A5AF4C5" modified="2025-10-08" version="1">MVAVWVVLFTVAVVLLTLWILKQERRRKRIDKLAGPRSLPLIGNLHQLKRDPKEFTIQLYEFCKEYAKFDVFRLMVAHHPLILVCSPDEIEPLMNSSKHLDKSSDYDFLHSWLGTGLLTSTGEKWKMRRKLLTPTFHFKILHDFIGVFSDQKTAMGRSVNAQKNSDSDYVRSVYKASEFTFIRQRSPWLWPDLLFNLIGPGKDYAKSLKILHGFTEKVIRERQEEFSKKYTSDTTMEQLLEKKDHDKMEGKQRLAFLDMLLCATSDGEHMSFLDIREEGHDTTAMAANWALHLIGTDPEVQKKVHQELDAVFGRSNRDAMMDDLKELKYLECCIKEALRLFPSVPVFGRSLTEDTTIGGVFLGKGTSALIVPAAIHMRDDIYPDPDKFDPDRFLTENSVKRHPYAYIPFSAGQKFAMLEEKVILSTIFRNFSVKSMQDREELCPLAELILRPGNGIKVVLTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMA9</accession>
    <name>A0ABY7DMA9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Lon protease homolog</fullName>
            <ecNumber evidence="6 9">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_022391</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7 8">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="6 9"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="66"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="698"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="183"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="794"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAQ98018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="879" mass="99065" checksum="BB6C53F18F5EA089" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNQ4</accession>
    <name>A0ABY7DNQ4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NEIL3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="75" mass="8574" checksum="3D33717D170378E3" modified="2025-10-08" version="1" fragment="single">MSEDVLTFKKSSVDIRPSVPCRQKYETMNDVDICSPVFNFRRAFSLIHEQTDRQVCDVLLDQSVLPGVGNIIKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPR6</accession>
    <name>A0ABY7DPR6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MAR_024060</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">MELC-2E11</strain>
            <tissue evidence="18">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine.</text>
            <dbReference type="EC" id="2.3.2.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Axon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RING-Cys relay (RCR) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.33" evidence="5"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19799">
        <property type="entry name" value="Bbox2_MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16463">
        <property type="entry name" value="RING-H2_PHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="RCC1" evidence="14">
        <location>
            <begin position="779"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="DOC" evidence="17">
        <location>
            <begin position="3328"/>
            <end position="3506"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="4005"/>
            <end position="4056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="34"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2404"/>
            <end position="2539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2553"/>
            <end position="2591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2657"/>
            <end position="2724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2783"/>
            <end position="2808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="3030"/>
            <end position="3149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="3209"/>
            <end position="3248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2418"/>
            <end position="2427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2475"/>
            <end position="2510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2521"/>
            <end position="2537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="2663"/>
            <end position="2724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="2788"/>
            <end position="2798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="2799"/>
            <end position="2808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="3234"/>
            <end position="3245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WAQ99687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="4255" mass="467970" checksum="8464BCD4A6CC25D4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQ51</accession>
    <name>A0ABY7DQ51_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="56758" checksum="2C1B65F211418106" modified="2025-10-08" version="1">MDRAPDLKVGMPGVRLSFQCVVCKTRTNPKNRRKINSELKQLILKRLPIELKDTDVLCNKCRIKHFYKLSPVENFDNKLIDQSDNEEYQPPVSKKTSFASPPSVRLNIPSTPKSHSRCFICKRPGPKLIVVPSEARFTAFVQRNVIIKSGTRCCPVHMDESQIKDEALQSVKASESAFVNRATVLELLNKLRASCNKTQKRFDFNTLNNEEYVDLTGLNKEAIRDICAGVEGHIRNTPVRDILTTVGIFFFKLKSGLSNTILGHYISVLGPYLSDGKNNDAKILNHIINTNVEDIKSYVHPGDIFVVDRGFRDSLQLLEDLGIQSKMPSFLPKGETQFQTEVANTSRLVTKVPFIGDFVQIICAVCNKYLPPLSSSCSDDDRLAQHMLQLATQENSLKTEIEESNLDKSRAVWVPVSDTDLEDFPRLTEDILRTLTCGVYQLKLCPGYIQEHLEGDEDIRVHKERSGLIRVRLQSRHVSAKQYNLWIKFNNYEIHGWYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DR19</accession>
    <name>A0ABY7DR19_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LRC28-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_024237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ99864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="256" mass="28693" checksum="4FD2CE850B2199BB" modified="2025-10-08" version="1">MQESVIPPAVLQCSALKHIYIEDNELVELPPEICQLHNLCVLNVTGNQLSSLPHTIGQLKNLTKLQIGNNRLTSLPKTLGRLSHLVTLEASRNDLQTVPRELLGCSSLKLLALDKNKLTWLPRQLCWLPSLQELSLAGNFLQYLPPTRLEVSANHVHGNDVVCGHMQEVDPGRSFLVPPPEITDVLTSTHRVPRLEELTMRTVARLLRHQEDVYVLGLPREVADHLAFPTDICAQEQLGNSCQNFVYKSAFPMELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRN9</accession>
    <name>A0ABY7DRN9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="124" mass="14259" checksum="9DE57483C94631B7" modified="2025-10-08" version="1">MTTPERVQKIVDTYESMLGELKRIPVQLKKLETEHLQLTKDIEKFKDSDKNSAANIQRLKEANSEVKKLQKENETLQRKLENLSNRVEGMQIKRQEAGNGTSGIGARQDREKQLQEQLVLLDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTL2</accession>
    <name>A0ABY7DTL2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_025429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR01057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052565">
        <property type="entry name" value="Glutaredoxin-like_YDR286C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR01057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="108" mass="12666" checksum="2092B9F5E3ED0F69" modified="2025-10-08" version="1">MLGQPVFAGHARHASSTGTTEPPLPRVYLFTKTDCQLCDEAKEALEPIMHKFVLEEVDITLPENERWNELYRYDIPVFHVYEEFVCKHHVDLLAFERALEKYKNGVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTN4</accession>
    <name>A0ABY7DTN4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OFD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_024816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055289">
        <property type="entry name" value="OFD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39063:SF1">
        <property type="entry name" value="OFD1 CENTRIOLE AND CENTRIOLAR SATELLITE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39063">
        <property type="entry name" value="ORAL-FACIAL-DIGITAL SYNDROME 1 PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16045">
        <property type="entry name" value="LisH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="652"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="363"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="667"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="734"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="867"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR00444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="946" mass="108591" checksum="5264B7A60173C664" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUT8</accession>
    <name>A0ABY7DUT8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_001810</name>
        <name evidence="3" type="ORF">MAR_008056</name>
        <name evidence="4" type="ORF">MAR_019527</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF60">
        <property type="entry name" value="SI:CH211-15D5.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR01498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR04158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR19972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="370" mass="41248" checksum="1A975D9DA37ADAD1" modified="2025-10-08" version="1" fragment="single">TDIRPRKTLHRTLTQDEEDDLVAWLRENSFLFDKSSAGFKYKEKKNSTWAAKEAELGLKPGDLSSIWYTNMRTQYSKLIKLTNKSGSGAGERTARQQWILDNFEFLRPYLVQLRTQRGSKFAEKRKELVLEETEDDDAASDSSAPSTSAVSGCRPKAARVLSSLTSELESVRGAITVAQDPAAHTGQFLVYLMRQMDQQRMNVFVTRATRLALDLAEESQEEKRRLATQEAAGHVGQQIADPVFAMPVPPAPTSSIYRRQAPISAAFGSAWQQNQFQQQDHMQQDFQLATNIAASAPPAHLTPLLKSFTHLQPPNVQAILQQPTCAYRSITPAIETPTTTASIIRQAMDMVSTPNSSPILTQEMHDAPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVW3</accession>
    <name>A0ABY7DVW3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">VPS11-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_025190</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23266">
        <property type="entry name" value="VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="10">
        <location>
            <begin position="408"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="697"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="654"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR00818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="804" mass="91959" checksum="26FE77975037C580" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWJ7</accession>
    <name>A0ABY7DWJ7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA/rRNA methyltransferase SpoU type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_008388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="3">
        <location>
            <begin position="216"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR01830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="315" mass="35112" checksum="D0490CBEFF951C91" modified="2025-10-08" version="1">MAADFCPLDVHGGRAKMRQERQRQFAKEIEKAKIEMENIRLVEQVWFDDYVNGKYVNDLTLNRPFANNDITPSDGDSIDEEVESKEVNENKNDLALMEAGTVSDAESRTNGYRVTNEVSHAADGSTCAEAESVHYFIQHKDVIYKLQQHKETMEGQSACLPNILVTRTQQISSKGIDKHRGKGQRIPLPEVHGEVLWGIHPVSAALQAGKRQIHQALFQKWRDAGGVIVGSTSNKEHSCMVPLHQFTADKPILLLIGNEATGLPDAICQHCDVLLYIGGHTFTSADHWHVSSLNVSVATGILLHSIMQTRLKTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DX71</accession>
    <name>A0ABY7DX71_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="155" mass="18200" checksum="C6819EC2E705E233" modified="2025-10-08" version="1">MAAPRRLRMALLEHELAQVRFQYNLVLAAILEAAERERQRARRRERRWWVRELILRRPLFGQYETLMKELEAEHAVDFKAFLRMEPQMYYELLNRVGPHITKSTTPTLIVTWHGTSDSSITGVPGHVVWLKCVRYTCQSLQTSSNNPGNETVDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXT7</accession>
    <name>A0ABY7DXT7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NUP50-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_007980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd13170">
        <property type="entry name" value="RanBD_NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015007">
        <property type="entry name" value="NUP2/50/61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF141">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08911">
        <property type="entry name" value="NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RanBD1" evidence="11">
        <location>
            <begin position="232"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR01422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="347" mass="37865" checksum="B3F6E8B28436F494" modified="2025-10-08" version="1">MAKRGASSELTDRNWDQEDEPEESGGKSAFSGFGGFAFKPTQTSTPLFSGGMFKTESKISEAEKQKDKLGTVHETTESAEEKSANGNHNRASDSPNRTAYLSNLKSLNMSVLNWIQTHLDKNPYCILTPIFKDYDTHLKQLEQDREKSESNGSSSKVLKKEESVKPMEAEKTEMPKTGLTFGMGTLQANSSTFSGAGFPAFSFKPTSQPLGTASGSGFSFAVGSQQNASGSKDDGAKGDDEDGCKLFYQKDGEWKDRGVGFLHLKKTDGKAQLLVRADTTLGNILLNIRLVDTTPMSRQGKNNVNLMCVVSPPIPKMPEDKPIPMLIRVKTGDDADELLHKMKEISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYC3</accession>
    <name>A0ABY7DYC3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_008229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="78" mass="9136" checksum="7C433F2ED18496CC" modified="2025-10-08" version="1">MDIQINAEASRSIANRYRYVADELEEKYTTRKKEMEDNAAKILRRQRMARHILWAVVEETIRNASILDEALGLRGQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E051</accession>
    <name>A0ABY7E051_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZNHI3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048371">
        <property type="entry name" value="ZNHIT3_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21373">
        <property type="entry name" value="ZNHIT3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger HIT" evidence="1">
        <location>
            <begin position="51"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="119" mass="13160" checksum="A25770306ECF8F72" modified="2025-10-08" version="1" fragment="single">THNDQEGNLSNCCIEKEPEKEVAQVLTQVDVSEVPDYHLGEDGSEDRVSLQQLQALEGSGELRVLLENPHLRQMMTSLVHSKVPGSLLEAAMQEPIFTEFADTCLSIVDDKNKVKLVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0W2</accession>
    <name>A0ABY7E0W2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_010201</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM263 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028153">
        <property type="entry name" value="UPF0444"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31443">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15475">
        <property type="entry name" value="UPF0444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR03643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="127" mass="13888" checksum="E2F6148001ED7B0B" modified="2025-10-08" version="1">MTSLYQTVKSCIIKSPPSEQVEVVTKETENDVLDNPEHVKEHDSMDFTSNKKTDEQSEQKAQGGVIWRVSSGLGSGLYNFTTGAVGYGVGGVKWAAGKSYDVGSSVVTHVKNPPLPEMLRKKKDKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E174</accession>
    <name>A0ABY7E174_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="168" mass="18153" checksum="18F2613BE485C5A5" modified="2025-10-08" version="1">MNYTNVKVSISDGQKEKLKSALQSGEAVSIRLSHHDLNGEDVLALTKAQVTKLTKAYQNGKGVTIKMSKTQIRHNLKEFFFLPMLAGLAATVAPILFKTVLPALHKYGCVKVETDGKGLYLGQASGSNFQAVGDGLYLKKEGVTYDGRGLLLGKNSPFKSIPILGMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1V6</accession>
    <name>A0ABY7E1V6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="83" mass="9927" checksum="B4E3D63F68B7C3BC" modified="2025-10-08" version="1">MKVVLQSHNVKHRTLFRTIFCNEIQWLLCTYNLKKHVKSFNNSVLIYLDKRIHYNISSYKTRIDLATFSLNEHIDGPYTPRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E201</accession>
    <name>A0ABY7E201_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="181" mass="19294" checksum="21EE04AF7294565F" modified="2025-10-08" version="1">MLSCSPSCVDGRRPTPANWMCDEDTVCVAHSTCQHTHWFDNSYCICDDGYLAKYGMCIRRGASIDNLESGAGSLQVGLWSVFTCIALGFMRGAKSCGRTDANHECLGDDTCIEHAVCADNLFCTCIEGYEAVFDLCLKKGAAGTSAGASLHSGMLSVFTCVALGLMVGAKLSRHAGYKFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3Y7</accession>
    <name>A0ABY7E3Y7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PCSK5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_020092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR04723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="229" mass="24883" checksum="822011A6FACDCC78" modified="2025-10-08" version="1" fragment="single">VKNIYTDTSMFPVAGEYAGNTTGDNDNYPDISESDFLKCPPFFDTAQQIDSTWIHGYTGRNVTIGVIDVGIDTDNPELEENIAGRIRKFHGERYPQMNASSFSAALGYKYQNIQIYSNSLTFVKPFARMEPFTARVVERSILQGRGGLFVFPAGLPGNGFANSIHTISVKCIGENGKVPPPVFANSATLLTVTHTARRFGDRKCDNKFGGSSAATAIISGIVALALQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E738</accession>
    <name>A0ABY7E738_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-mannosidase</fullName>
            <ecNumber evidence="2">3.2.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_019750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="2"/>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045111386" description="beta-mannosidase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="7">
        <location>
            <begin position="36"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="6">
        <location>
            <begin position="220"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR04381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="671" mass="75955" checksum="FD64AD42694C7468" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EE68</accession>
    <name>A0ABY7EE68_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SCAF4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_017303</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF4">
        <property type="entry name" value="PROTEIN CBR-NRD-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CID" evidence="6">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="477"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="352"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="778"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="401"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="808"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="829"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="841"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="966"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="983"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1062"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1166"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1185"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1232"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1253"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1266"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1283"/>
            <end position="1301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR07345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1317" mass="146016" checksum="5A5FF467D8F05AF3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFU6</accession>
    <name>A0ABY7EFU6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3504 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052787">
        <property type="entry name" value="MAVS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21446">
        <property type="entry name" value="DUF3504 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21446:SF12">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="40876" checksum="9EA25262A45B51E4" modified="2025-10-08" version="1">MSLRTSGGKCIVSSHSGGYFRKCSSRKMTYLGAENANFEEMPKYALNNHLRMFFASIRTEKGEELKKSTMFYVKYCLLKYLKDKCRIDISTDNDFVAAIKTFKAKLTDLQKKGKGSVVHKPQIADYDMKLMDPANVAFNVNTPFCLQNKVWFDIMEKKKTTFAVEVDSFGREYVRQIMDEAEKKHGIDSTPDDTIGEARMYARPCDDMCPVKYFKRYMNFIDDLWQRPRDSFNTTDDCWFCKSPLGRILLGNMMSQISTTAALSQKYTNHCIRATSISALDMAGLEARQIIRATGHKSETSIKSYASRLTEGTKRKMSDALSSAFLGAEQNAPMTSDIFPNCQRMIKYFQLKMTFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGZ2</accession>
    <name>A0ABY7EGZ2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CRY1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_018307</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF30">
        <property type="entry name" value="CRYPTOCHROME-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptochrome/DNA photolyase FAD-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR08349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="165" mass="19132" checksum="E71267E5AE761D30" modified="2025-10-08" version="1" fragment="single">GKTGFPWIDAIMVQLREVGWIHHLARYAIACFLTRGDLWISWEEGFKVFDELLLDADWSVNAGMWLWLSCSSFFQQFLNCYCPVGFGKQADPTGDFIRHYLPILKGYPPQYIYEPWNAPESVQVAAKCIVGKDYPVPMVNHADSSKLCMDRMKQVYQMLLKRRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHX4</accession>
    <name>A0ABY7EHX4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SC6A3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_017957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR07999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="134" mass="14719" checksum="D6B22B5A57BE8237" modified="2025-10-08" version="1">MLSDWYIATFNIVFVALMETIIISWIYGANRFSEDIEMMTGNRPPLLVRIVWSLIIPIFISTILITSAVNFGVPSFGKGGYQYPDYAVVLGNVLAFAPLVSIFVVAGVLVAIKGTESLPANATGTRMVPERREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIB6</accession>
    <name>A0ABY7EIB6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="69" mass="8089" checksum="4AE98A6D30259F97" modified="2025-10-08" version="1">MVPYLNKYSLRSNQRMVPYLNNIDSLGSNQRVVPYLNKYSLGSNQRVVPYLNKYSLGSNQRVVPYLNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EK65</accession>
    <name>A0ABY7EK65_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HARB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_035463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF227">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="74"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR10387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="203" mass="22759" checksum="867B249FA43464F8" modified="2025-10-08" version="1" fragment="single">FPTTLEERREASLGFYTLCGIPRVLGAVDGTLVPIIAPHDNEEVYVCRKGYHALNIQAVVNSNMRFVFRHLELNDVGMLLGDSGYPLRHYLMTPVLRPQGIQQTAYNVAHARGRVVVERAFGLLKSRFRCLHKTGGCLMFSPDKCAQIVTACIHLHNLCLDRHVPMPGTVLRQDGQDMDQQPLAVPAPNHSGVLHRNILINRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELG1</accession>
    <name>A0ABY7ELG1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="440" mass="49317" checksum="F4F72F0B896F76D2" modified="2025-10-08" version="1">MSTSGKLISVAIDFGTTFSGYAYSTKGDFKQDPAKAETEYASLKVTTTTTFRDENGSSMNALKVVSAAGIPENRLILVYEPEAAALFCKHTPFSKEALTGKEESIFSEGSKFMIIDLGGGTIDITSHEVNCDGRLDALVEPSGGPWGGVLVDAKWYNLLEELFGSDVVNEFCEDFTDKLDLDRVIEVKKRVIRPSETEFTRVKFPTLLFEIFAEKNGNMSFQQKLNNSKFENKVKYKRGSLEILNKLLQETFCDSVSNMTAHVQRELSREELKDIKTLILVGAVIFGHCKDFIKSHKLPYSYGVSTTVPFDVNIHKEVFKTVMKNGSLMCNDIFHPLVRKGEKIVVEETTREELFRSPKPGMLHVEVDIYKIPQDVTPGSVLYTIDCKRVCTLNLAVENIQCDEKATVIVQMQFGGTRIEFSAKEFGTDNSVSCKPRWFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELW9</accession>
    <name>A0ABY7ELW9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTBD6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_035048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF4">
        <property type="entry name" value="AXUNDEAD, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="31"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR09972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="393" mass="44474" checksum="AF11AA1FA3D8FCEF" modified="2025-10-08" version="1">MADFIESMEDWQGERNLVDCNRFMFQNQINCDVTFLLGLKREAISAHKYMLVCRSSVFQSIFCGTIAGDKNTIPVSDVEPDTFRGLLLNVKDLLYAAKKYAVKGLVEQCLNFLHSSITVDNVCTILEMVHMYNGKNIEGKCISFVHEHAKEVLKSRTFTKLCQTCVQQIIQSDEMILDEKTVLEAVLKWAELECRRRNLSEIISMYQFYNGRAQQSSWKFSARKRRGFSLHSVLRYSFISMEGFHKSSTEEKDVIRFSCSEPILLHGVIVYGSIDDNAEYDARIELSADEDKGLLDSCFNRLSTTRMEHTYEIMFSKPVSLQTGKQYMVSLQMTGPPTKLGSGGKVDCVSEGVTFHFLSKTGSRTTVEKGQIPGLLFTALTKQKSTSSVASNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EM03</accession>
    <name>A0ABY7EM03_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SSPO-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_034902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF386">
        <property type="entry name" value="HEMOLECTIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="3">
        <location>
            <begin position="290"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="3">
        <location>
            <begin position="568"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR09826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="930" mass="102143" checksum="5E3D68DF32333626" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMJ8</accession>
    <name>A0ABY7EMJ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C1QT3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_036131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF33">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="C1q" evidence="3">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR11055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="120" mass="13411" checksum="92CB4594647D351E" modified="2025-10-08" version="1" fragment="single">MEQNSFVFRRSYSRPRRSAIKSQNQGQIIVFKDTLSNYGNGYDNNTGIFDAPVSGSYLFTVHLCPVPGFYIVSNLVNDGNIQTTDSNYDKEGSVCNTSEAIVYLEVSSKVWVEMYNGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EN26</accession>
    <name>A0ABY7EN26_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_034875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047509404" description="EGF-like domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR09799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32418" checksum="05416DF9C60C5DD7" modified="2025-10-08" version="1">MDGAQNMRGLYFFAAVMCFALTVHSSVAQADATQSGSQNCTDLDPSEINNCTKNANASNTPVPTSNNSTTPPATSPNSTTPTPTTPPTTTTTTTTNIATTTSSTPLAQITSTNVQPTPSTTTQGPMATTLFSITTTKTTSTSTADSNSPTSKTVASNITTVTAAISTTMETTKQSTSLVTRYPTQKPDVGGCSKGYRLQDNTTCIHLCEDKTCLNEGECEVVIKADDKTEAHCKCKEYSDHIYTGADCAEKQISPKRQRSIILGVLIPIACILLLMVIYTCCKLQRQRTAERSFRNKYDLNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EN91</accession>
    <name>A0ABY7EN91_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_025490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045740400" evidence="3">
        <location>
            <begin position="22"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR11310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="248" mass="27264" checksum="D4FC01CF36B79863" modified="2025-10-08" version="1">MPFCGLSSGWAKLTLLVVAAAAGLHCAALATPYWMKAATLSNSVNITVGLWKQVNCSRAIGPPWSPWSPCYGQPLADTYQTLLFKVTQILECVVLVPAACSLVLCAYYITSPTVRTQTVVGWLMAFTFSSTALNLSGCITWLLNLPNAHFAFWSLGLAASAAALFFLAGILIIPDFRRSFVFHRDVLSSCTHPGHLLGTDHICTMEISRFFVTRQSLMPPSMEMCDRQANKDEDESKDALNDSKYRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EP55</accession>
    <name>A0ABY7EP55_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="77" mass="9098" checksum="59D6A3FF71ACCDDC" modified="2025-10-08" version="1">MMWEPGLAKFTQDHRFVMSLHMMADVLPHLAEVSAALQDLAEHFHLPVDKTLSEWRQKLAQSKTLQLTPEHWHNYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPA3</accession>
    <name>A0ABY7EPA3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047351751" evidence="1">
        <location>
            <begin position="19"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="121" mass="14103" checksum="9E93BC8C84135C23" modified="2025-10-08" version="1">MGIHLVLVLMICLINGTALLQGVDVHLQADNHNNGHPNHHKITLKHFSEHTLCNNIRGKVMFLTALDDYFHNISETTRINFIFDLCARRGDMLIKWVKEVFDKDGDSSISHFERIYYENRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQF3</accession>
    <name>A0ABY7EQF3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CONT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_025507</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="272"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="381"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="495"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="587"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="679"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="800"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="908"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1010"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR11327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1151" mass="129682" checksum="30CFBC1D539F9663" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ER32</accession>
    <name>A0ABY7ER32_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="228" mass="26410" checksum="190674BEFFC9BAD2" modified="2025-10-08" version="1">MKRNFSTLVNVCLVVFVVSLIVGYTKLNMISVNSSSSPPPITKYDLRILVIVYNRAQSMLRLLNSINEANFDGDNVKLEVWIERSKAGVVDTLTVKTAEEFVFKHGHYEVSKHSKHVEIYRQLFATWKPRVNSSEIAVILEDELTVSPHFYKYLKLVHNKYDNVPEINVIQNKIFQPYVPGNVISAWYKILQAQGRADGEQSIYLIYHSWKIKEYTLYPNFKGEQSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVW8</accession>
    <name>A0ABY7EVW8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="5">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_026848</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR12668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="162" mass="18434" checksum="9A6D4D19C76253E2" modified="2025-10-08" version="1">MAKKRVRGASVLTAIKCCVDEGLEPVCIERSSYIGGLWHYTSEVEEGHASIAVVAFGGVPYEIIIFPHQACVMKSTVINTKEMMCYSDFPIPAEFSIYMHNTRVDKYLNMYADEFGIKTYIQFNREVYLSTRSGAWIFSGVEDGDPFDMRVNTRFVMAQRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EX36</accession>
    <name>A0ABY7EX36_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="CARD" evidence="1">
        <location>
            <begin position="375"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR14512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="459" mass="51720" checksum="1DECDA675D8F777E" modified="2025-10-08" version="1">MFHEIKGKNVAYDRDHSHASWTPIQSGGIVFTARPLTGFEPVTLTLEGTGAIELGITTKDPQSLGGAVPETTQLLEGYHFLNDVKIHKRKCTMSINLDESAMEVVSSYGGGHYKHRIQSNTDYFVVAEVKYGAVELRLEATGNDNTRQEFSENHGRNIKRLNNPAVTTSLHKSPAALCFVSEPLSPEVTIKLSCTPKPYQSTIPGRFYLLLRYTKQDPREFQIKNRGKFDVSVPLGDNDEEPAWLQIEKLEKDECTGNAVVLKFTGEAIDIWSAKGRRKRTTCHLRANEKVWLVLELYGITVRVETSFLEGPSPSHFLCPDIPEDPYENSAVHAYYRYDTPSEHENEALPVQGPTFVPASTAPPASPEDPVYLKDVIQKHFTYLKNNFTVTDVIDHMYENKMITHTELTSIASHQPAMQTRSVLVNILSNRPVSKKAFINALNKTHQEFLIEKFFPEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EX66</accession>
    <name>A0ABY7EX66_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SMKW-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF613">
        <property type="entry name" value="NUCLEAR RECEPTOR-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="297" mass="34153" checksum="1C5324C94E37BB81" modified="2025-10-08" version="1">MISNSFTQEACTKHSEDYEVTEMIDYGSFGDIFKVKTVSDNKIYAMKQIKYRGLFQNDPYIMNEIYCLTHLKHKNIICLHEIIIDTDEIHIIMEYAANESLDKFLVDHKDMEFHHRYKLFSQTLQGVMYCHDMDVAHRDLTPSNILLTKDMVVKIADFGLAVKCFTESGEPVYCTDYIGHTSYLAPEVLSQNPFLPKPADLWSLGITLLFLIFYSVPYNGLQEDVLKDILRDTWTTFVESKSKTAGIVVKQDIVNIVESCLRVKVNSRPSICDLIREWDNIAPDSLLDTETFTVGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EYX7</accession>
    <name>A0ABY7EYX7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="97" mass="10934" checksum="6B13707B27AA0566" modified="2025-10-08" version="1">MARVSPVKMCKEGTLPVRILGVKDAIAKAKFLPKYNEITIDPEDGATFANDGDFIHENEKVKITIPEFCRVLFTHAVTKKDVELKASLKECVHFMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F058</accession>
    <name>A0ABY7F058_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="209"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR14461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="416" mass="45570" checksum="B1C22AE400CE83F7" modified="2025-10-08" version="1">MDAYSKIRKLRKKLRQIEHLELIERDLTDEEVAKCIKKNSIREELLSLLHDNTNPSISVGEDDNDISSSTAASYSNTSQSQSDFAQPPVSEVDVNVSVDDEEADENEWVKVIKDLNPGNVNNSSRNDNNGNGEAADEKNSVGSDGGKVATDADAGSTMTKRAVTKEKDVFKKPSSPDVSPTKKLKTEKGKTKSGLVEKWRSSSFNVQVLEGHNDLILTVDCADNILVSGSRDTTVRVWKLEPSARELRCLGGELLTTIYTYNPITKVAYYGQNAWLIIASGLVKKLANHREEFGITDTLCCHVFDITSDPVYMATIDDSDTGRILDLCCQETSPGVITMATAGMELQVWNQVPSKSKDATVSAVFSPQLARFAENSDIESEAEFTDTDSESPEGSRASSRRGSVQGQGYMSWCSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0E6</accession>
    <name>A0ABY7F0E6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037221">
        <property type="entry name" value="H-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019019">
        <property type="entry name" value="H-type_lectin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09458">
        <property type="entry name" value="H_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141086">
        <property type="entry name" value="Agglutinin HPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H-type lectin" evidence="2">
        <location>
            <begin position="95"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR12836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="166" mass="18869" checksum="BA4415CFC55C8AA1" modified="2025-10-08" version="1">MAFLRKEQLETKQELRQAKDEIAKLQEHPRRTDYTVSVLNKAVDFLKSNLVNENTALEQQLTKTVLGISASLKEKCQSGEFGPIAFDPRPSYPATVTITFRPAFRSIPAVVYGLKMLDSAYNANVRVKETITELTNTYFDFRISEWADTVMYGSVFSWMACPKTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3W7</accession>
    <name>A0ABY7F3W7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046487156" description="YqaJ viral recombinase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16934" checksum="40DAE93BE91FD33F" modified="2025-10-08" version="1">MKGKCKQAITTLLLQFVDSTFPLFAATPDGLRSCLCLGQGLVEIKCCFKNRNADIADISVSSFYLDENKHLKRTLRYNTQVQFQMYVCGKSFCDFVVYTHKGIVIETIPYNPDFVNELISKCTQIAINDLLPEIIQRIFQMRSKEMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F488</accession>
    <name>A0ABY7F488_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SER2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_030465</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF120">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="60"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR15871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="435" mass="50043" checksum="0C1684724E3D01D6" modified="2025-10-08" version="1">MLWYSARFLYDSYSLQTTFTMNGTICNGTCNTEANKVEITFGKILVGVLLYIIVIITVIGNILVLLAIKFRKCLRTTFNYYIVNLAITDVAVAVSAMSFKATQAFYGTYWPFGEFMWMTFVSVFTLILISLDRFWSVTWIQHYRQHHSKRLLMLALWVPPWLSDRLRHSKPGECYWNPALNVEFVFIIATLGHHGPFLVLIFCYSRVYAFMKRRGVGLLKTNKVRSSSIRNINMTEKFSDTCYVNSVVPEGSQCNTGNLSAQQEQRASGMTKQASTSKDKSGIFIVEASNLLTVPSHFKHYTNITSNCERKTNESLKGDEHSEHFQSARTTSLSVDPIDQNSTQTVSRRIKHRNVKDKRVFKTLTYIVIGYVILWLPFHVVFDISIVYPGLVPEAIIETVFWMTYLNSTLNPFLYNFSCPVFKEAFYSILCVRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5F5</accession>
    <name>A0ABY7F5F5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like family domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_031979</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="109"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR17385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="260" mass="29690" checksum="9257A7D7F93F83A3" modified="2025-10-08" version="1">MIQFIRAVIVTANQNDIASLEKAMEGADAMFLTTHYWEDKNKEKEIVRGLNSIDAAVHKGLTHIVYNGSENVKKSIGRECGHLDSKAAIEECELHYHSVAILPFSPASTLPMEDKPLDMISVADVGECVMNIFCRPRFYSRKIISLAGDRLTMEEIAHVFSKYVINKKFICPKIRIKDYEKFDFPGAHELAAMFEFYKNGQITRDIKMAKRLNSNLQSFDKWMDYEAETIENAIKEGDKELEITKNTLAVTKETKVNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F733</accession>
    <name>A0ABY7F733_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ZN234-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_032026</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR17432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="296" mass="32727" checksum="7D8ACB6E135D0221" modified="2025-10-08" version="1">MQVHMVTHIQTVNMVTHTQTANMVTCIQAASMVTHIQPASMVTYTGCQHGHTYSLPAWSHIQPASMVIYTSCQHGHTYRLSTWSHIQPASMVTYTGCQHGHTYTGCQHEAGSKGHDGFTQDGSLHFECPQCGKTFAKKQNLKLHLRTHTGEKPFSCPVCGKCFSRLLIEAVTDDSSEPVFVSVIEENTSSRSSLGCMKCPYCHKRFPSISACDMHVRVHTGEKPFTCEHMTAASWAKVCHICNKVFKGSSALQMHIRCHTGEKPYKCNLMAAVMYKGGSATCARRHSRVLGASRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F841</accession>
    <name>A0ABY7F841_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_031447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="167"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR16853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="272" mass="30464" checksum="7CB4B0A31318E8D9" modified="2025-10-08" version="1">MFSCVIVFILVRERIVFHVSQPVVSRAKTVTMDIIANGAVLQIVCLVENQMGIAIPVIVVLIVKLHVRSASHPDVKLVLTDIGEVFVSITVAITVHHITKVTACVYLVRMGTGEVNALRVVLNVKHAINQTDVWSVVLVTMATHVTNTIAMVAQNVNMAMDHFVMQEKNADDVSAQDITDMFETNEDDDARVVVRGGDTDYINASYIDGFRKRKAYIAALGPMAKQLGDFGQFWRMVWQQKVERIAMVTNLVEDEKTKCEQYWPDHGQFSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8R0</accession>
    <name>A0ABY7F8R0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PCFT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_000223</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR18385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="466" mass="51363" checksum="8D334CF65400957E" modified="2025-10-08" version="1">MGGFELSSANGETNEQHGNAPERNEGPSTRNRTWRNWLIGAVGFFYFGGAQMGLFVIGQYIYRRIQIEAYPNKTFQTGISYCDYNNSNPDVLLLAGVQKKAAHYNVIFNIASGIPAVFVNIVIGSYTDRFGRKFLMVAAMSGTFIRVLICMIGAYTTMKIEFFAIAFGAEGLSGSVFCYLLASYAYVADITTAKNRAFGIVANEVAIGLGHTLSVVAAGFVIQAIGFNQPFIVALVCIAVAITICVVLLPESYPKEMRAKPSQTCVTLKHAVGFYYASWNYGFRWRYIVAIVVFYFTMFDVLGRNSVETLYQMNAPFCWSPTKLGLFGAVRSLLQQIFGMFVIAILKRLSMEDDTIAIVGCVSYGISFVIEGFAKTDVMLYVGSLAAGISAVETFCQMTSNVITNAFYKATVASRGGAVFFLMAGFNIISLILMLFLKFVSRGDAREKRARNYSITPISFVEKQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F912</accession>
    <name>A0ABY7F912_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR17491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="347" mass="39787" checksum="E3F8B0F5130BBC49" modified="2025-10-08" version="1">MNDLKTEKTLSMTFQEFLTSLDLSKEDYIQANSDVDVHNDVVCDSQGQKQIISKSKDVVLGDMTEVVKERIIQKIPSDISKTMGLASNVRTAIGLNNELSCNVDVEDGLTNGADEGHFDKSKSFKYLWARFEDEHIGRKCRETNRSLYNIKVNKHWTPIFRIKRQFPIDRYQSALVMRSQFPIRCAAAKTCHRCQGDTLQTAVVDFAGKGFAHAHYVALSRVTNLENLHVRNLNEPKIRVDKRVLSEMDRLKETSVLPIIDYCLSQLQSCVFSLLYQNVWSLRKHFQDILISPVHNLSHINIFSETKLSEKDNSGDFIHPGFQFHRYDSKHSCTYGMAAFTKPEVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F937</accession>
    <name>A0ABY7F937_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SIR2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_000373</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-hexadecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:14175"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138936"/>
            <dbReference type="ChEBI" id="CHEBI:189673"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:70564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-tetradecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70567"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15437"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:141129"/>
            <dbReference type="ChEBI" id="CHEBI:189674"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:70568"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR18535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="235" mass="26274" checksum="C371A69EE782D7DD" modified="2025-10-08" version="1">MLIAAQMYAHKDSLVPYCTEEDCDGFMKPDIVMFGESLERNFMDDAEEIENCDFMLIMGTAMKVQPFSKLPIKTKFNVPRLYINLEKPQVARHPMTALFFGGGYDFDNEDNIRDVFVGDKCDDACFKLADLVGWGDEFRAMVQEENAKRGVVWPPPVQKPSPGPSHSKTDKPCPPTQSKTDKPQAAKNQPKSQSSVNKKTFSSGNITTQSKAVKTQSKPDIKIAARSGKRNTEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F962</accession>
    <name>A0ABY7F962_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_000563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR18725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="84" mass="9216" checksum="51026D73190D1815" modified="2025-10-08" version="1">MTLTPAFDEPLVVYDTDACNEPLVVYDTVAYTDACYGPLVVYDTDACDEPLVVYDTDACNEPLVVYDTGAFDEPLVVYDTDACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F975</accession>
    <name>A0ABY7F975_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR17909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="339" mass="39296" checksum="9654D6E6B208134F" modified="2025-10-08" version="1">MVLIQEIINTSDDAEHAKHLLEPYKRSETKHYKIDKSETKWIQWKDIFIIECGLCDETVYVSLVVKLNRQVHLFLGESLSRCIITSLVLIAVLHSNPMMWRTSTIMIRLPYCLVYLRLFKYNSCQQLISGGCNHVKDTPELKLHLEHQTQVVSKFSLKWPYDKLCDVLELYQQKHINIIEWLYKRFPFAGSLPITKSACALLSITGGYLARNTYDGGYKPFEAEPHIHFEKVTVAVVEITRKYIRGVQATDAHITENICSNVKELELLSDNLKPDVIDKATPLRMTAKSTISHRLRANNYPKMTPLISTTSSKATVWKNSRRDINLKRMTRKIMKRKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FB98</accession>
    <name>A0ABY7FB98_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="347" mass="39240" checksum="F68A65DBE729FF59" modified="2025-10-08" version="1">MAHGGVSRDEAEMKIDVEGIASPGRRPRGYACLLVNIERVGTRGEYTFKTREGAIKDFTCLRETFCERGGIEYQQLNEGPHRCQNITLEKWDHEKRNESTVKSLHKPVEAFKPDPQCCLKCLIKSTDFTGTEAFVFAISSHGEEVAEEHTKDDTGVSMFVAVPNSGHEEEQAGNSRENISDDPTRIGRFCVTEVEEFGFQCIFDIIPMDFLVLFPSVSGKRSKRNTKDGSWMLAHLKTTVTDTISKGIEVDFLDAVTRVAQLVGNMESAVYKRNETGGHSLDARENQIVNEEKSGLKTAVCLVHRLRKPLVFRRVVTPVFIETATNDVDFKPGKRKKWRQLLYYNHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FE18</accession>
    <name>A0ABY7FE18_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">S18B1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_001655</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF28">
        <property type="entry name" value="MFS-TYPE TRANSPORTER SLC18B1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR19817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="505" mass="54087" checksum="CA57216E8D86316C" modified="2025-10-08" version="1">MLPTEKEEVLTVTYSSIGEVVMCNGVHCHNDNERATERSPPLPGPATVKCRPADASISTDKADDGSNDSRGSGLRSLTRPQIIILAMAAVSDLLVFMSISIIAPFFPEEALAKGVSDTLSGWIFGTSPFVQFLVAPFIGKLMPHTGLKFMYLAGVFLFSGCTILFGLLEYVPTDNGSGVFITLAFCLQAVRSVGSASTSTASFTLLLTHFPDNVSMAFGFCEVFVGLGLVSGPGLGGLLYGAGGFVLPFFTIGALALLCLPVIACVAPFPKHEGSISKDVKQSQGSYTQIVCNANGIIISLTIISSTVMWSILDPTLEPFLRKFHLSPEIVGVLFLVMAAVYAASSPLWGWLSDKITDKRPLPIIGFMTACCGSLLIGPSPLLGLDANYSELWLVILSLVILGASSSLCSVPTFDMFLMTAQEQGLEDNTMTYSLVAGVWMSMYSLGRSFWRCSTRVITGGVVGAARTYSSRRSLVIILLTIANVQDYQLDASFENSEKTRLLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FE96</accession>
    <name>A0ABY7FE96_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="108" mass="12417" checksum="0DD1A9E5E1046562" modified="2025-10-08" version="1">MTDTFMVNQGKMADTFMVNHCKITDTFMVNQGKMADTFMVNHCKITDTFMVNQGKMADTFMVNHCKITDTFMVNQGKMADTFMVNQGKMADTFMVKHGKLASYDWRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFK2</accession>
    <name>A0ABY7FFK2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CRB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_014824</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897:SF2">
        <property type="entry name" value="OS03G0226600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897">
        <property type="entry name" value="OS10G0105400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="4704"/>
            <end position="4722"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="4626"/>
            <end position="4671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1067"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="4827"/>
            <end position="4846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="4890"/>
            <end position="4909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1071"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1081"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1093"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="4661"/>
            <end position="4670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR20850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="4934" mass="550482" checksum="878BE2EDE1CDA462" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJX7</accession>
    <name>A0ABY7FJX7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="199" mass="22971" checksum="A1AFA64D27DBE251" modified="2025-10-08" version="1" fragment="single">MAVYMMMLYVTREQENAIHELFSQRTWPLLKSDPSSVLRGPQHVFTFGSLQDRTWEFHTVPATQLSAMPAEEGEENNIVNGEGVEVQGVSELNDNHGDEIANNIEDAEHDTEDMSSNIQDMEDNTEDMSDNIEHMDDNIEDNIEDIEDKKVDDKKKSDNSRKKKKINDDDYIPYKYTYPKPPKKPKTPRKDKESKPPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FL63</accession>
    <name>A0ABY7FL63_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATS10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_036609</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd04273">
        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF256">
        <property type="entry name" value="PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="4">
        <location>
            <begin position="284"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR22940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="486" mass="55490" checksum="FA25181C0F88DA9F" modified="2025-10-08" version="1">MTKIRESLLTSLRSYETIIPETVDEHGRFLSYHVQRPPSRRRRDSQSQSEIIDDSDISEYRIFYRFSVFGKEFHFDLTLNTAFLAPGFKVEYQDKNGVIGTSNAVANCYYVGQSRKPFISTAAISNCYGLHGVFSTADEDYFVEPLWNHTNAIQADGHPHVVYKRSSVIVPSLNAHCGVNDKSKEKVTPKYSSSQSFSSHWQLKHRLENFKHIRANDSIVHKLVPRKVYDIPQPPVRKPFLEKEPYREVDKETDARHGHRHDNRRTSGRGRRVRREVTLQMPARTVETMVVIDQQMYEFHKAESIVEPYVLTIMNVVAKLYRDPSIGNSINIVVSKLVILTEDKENLSISHHADRSLDSFCKWQHRENMTADQTHDNAVLLTRYDICTYKDEPCGTLGLAPVAGMCEGERSCSINEDIGLASAFTIAHEMGHNFGMQHDGAGNLCGTPGQEPARIMAARLTGDINPFLWSNCSRQYITDFLEYVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLF2</accession>
    <name>A0ABY7FLF2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CES2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_001889</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd14695">
        <property type="entry name" value="bZIP_HLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040223">
        <property type="entry name" value="PAR_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988">
        <property type="entry name" value="THYROTROPH EMBRYONIC FACTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988:SF56">
        <property type="entry name" value="TRANSCRIPTION FACTOR CES-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="235"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR20051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="299" mass="32892" checksum="EDBED6A81AE0DD85" modified="2025-10-08" version="1">MIIMNSSKGPYLGISGCNLIRNFKSVQIDVYYDESRQAPVMIAKKMTEAALDLSAKSSLGSTKSDKDSFSLNYAPESPPSPRTPLRHTSGADDNESDSSSAPTSAIKAVLGPVPSSLRDSPCSVADGEKQDSLPSSPSTPISRPFSSYAMESMASMFSSQSSLLAASHSQMPMGMGLSSLYDSSSAFPAFPVTPLTSHLLQRKRRAESRASVSSINDNSDGEGKKLKHVPDENKDESYWERRRKNNEAAKRSRDSRRHKEEEIAMRAAFLEQENLKLRAQVTILKNETAKLHYMLYNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLH9</accession>
    <name>A0ABY7FLH9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ciliary microtubule inner protein 2C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_036737</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CIMIP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052329">
        <property type="entry name" value="CIMIP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018902">
        <property type="entry name" value="CMI2A-C-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34924:SF1">
        <property type="entry name" value="PROTEIN FAM166C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34924">
        <property type="entry name" value="UPF0573 PROTEIN C2ORF70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10629">
        <property type="entry name" value="CMI2B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliary microtubule inner protein 2A-C-like" evidence="7">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR23068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="198" mass="23242" checksum="F45313F9AF8A6AF7" modified="2025-10-08" version="1">MSRSAGTLITTHNSTFIPPRYRGHCPTTKYDYGETYGNATNKYFQDYRSEVLNASHDPYARGGEFPTYYTHKPESVISARGRTRDRWLAAPKYSLSNLDFDRKEELKSFDKLGQKHREFYGDKSGTRKSVDYFMIPNSAEDQIKRKSQFMILATRHTDDINLPYLEHEARRLPLIKRVSTSASSQRDREMRDVYFEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLL8</accession>
    <name>A0ABY7FLL8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adipose-secreted signaling protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_016033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADISSP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026794">
        <property type="entry name" value="ADISSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13287">
        <property type="entry name" value="ADIPOSE-SECRETED SIGNALING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13287:SF2">
        <property type="entry name" value="ADIPOSE-SECRETED SIGNALING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15006">
        <property type="entry name" value="DUF4517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR22059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="156" mass="17800" checksum="C42D07A4DCC23BC4" modified="2025-10-08" version="1">MSNSSSEHKVHFQPVEVQAHDSEITLKYSEKRIDVHLGFLQINRHYTVTFVMQDDLGEDLTFDPLQNLHARVTKYEPTEDGLGHQLEMDFHAHREKLIQERVSVKSITGNGNYRDIVLHARVLGKGKGTPALRNGIKCSQVDDDNDSDVTDWQGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMJ5</accession>
    <name>A0ABY7FMJ5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_016130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF422">
        <property type="entry name" value="CADHERIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045583566" description="Cadherin domain-containing protein" evidence="9">
        <location>
            <begin position="30"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="299"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR22156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="591" mass="66170" checksum="168C3E44448B7DEA" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMU4</accession>
    <name>A0ABY7FMU4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="217"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="764" mass="86938" checksum="8F0D7363777EB44D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FP17</accession>
    <name>A0ABY7FP17_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SAS6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_037474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd10142">
        <property type="entry name" value="HD_SAS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.20">
        <property type="entry name" value="Spindle assembly abnormal protein 6, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032396">
        <property type="entry name" value="SAS-6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038558">
        <property type="entry name" value="SAS-6_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281:SF2">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16531">
        <property type="entry name" value="SAS-6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle assembly abnormal protein 6 N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR23805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="113" mass="13096" checksum="72A6DB3100182EAD" modified="2025-10-08" version="1">MADDLFSKRVPVVFKSQDREDRRGSICVKMELATVTAPTTRKELVVRLTDEKDLFFLYTLRLGEEDFQTLKMQQGLLVDFGAFPQKFIDLLEMCLKEEHKEVPKTSTACYNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPX2</accession>
    <name>A0ABY7FPX2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TC1D1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd21451">
        <property type="entry name" value="DLC-like_TCTEX1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="138" mass="15602" checksum="8B7FD4F98833A48C" modified="2025-10-08" version="1">MTALGKPASSLFSVPTHRELQTHGSSVTSYAWEPHEESQRKAKKVYYENTYKMEPPEKFRSDKVKPIIEKVLATNLEGRKYDPIECSILSKALSDDIKQQIQDNLFGDFGPEERPGGQCGQSILVGRRQGQFCNRLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FS47</accession>
    <name>A0ABY7FS47_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ID2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_037287</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd19684">
        <property type="entry name" value="bHLH_dnHLH_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026052">
        <property type="entry name" value="DNA-bd_prot-inh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11723">
        <property type="entry name" value="DNA-BINDING PROTEIN INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11723:SF17">
        <property type="entry name" value="PROTEIN EXTRA-MACROCHAETAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR23618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="168" mass="19204" checksum="EDCF6B7C5B5C7191" modified="2025-10-08" version="1">MKAVTQGITRATDFGLKSDIFRISKANMNDGEMAACFLKLKELVPSIPHDKKISKTQLLQHVIDYIYDLELSLEVQPVVFTQTPREPLSEKSIPNTFESELMDSCDAELERPVSKLLSSDQKPGLTRTLFGISGSHSMGESLRYGHYTRQRQFRYVWVASRRSRYAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FT98</accession>
    <name>A0ABY7FT98_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="77" mass="8202" checksum="1BA3C99B2530D8EB" modified="2025-10-08" version="1">MSGLSLPPIRSGLPTVQSMPNLQNMMRPSSGSSDAGSTASTFLPPLYNDTCTFNAPRAVHTPRTFSKLPAIGRRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTC0</accession>
    <name>A0ABY7FTC0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sister chromatid cohesion protein DCC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_037775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR24106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="221" mass="25024" checksum="DC6E0D5B9BF58BE6" modified="2025-10-08" version="1">MEANESINTRSLEDIASVLDFAKLDRSEIKSETQSVYFSEHLDSESFRLLELDKAVLEAIENGEKVVLRGDKEDCAVLCTDSQTFEVKQGEISNAMLILPNIHFGPELSTNDEPSVRYNEFTFNELLDLVQGSENEINTALHKMQALIIDGYWRVLDFDFLVQVMGHLLQLCDENDWTHSGVPIEEDLETDKMDVTAMLTKVARASMSKGIKVYNSRKPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTP7</accession>
    <name>A0ABY7FTP7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ANX11-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_037750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0041">Annexin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR24081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="252" mass="27468" checksum="AB675642252D3EB4" modified="2025-10-08" version="1">MAASYTQDLRSELKSEISGRFEDLVLALLETPVNYDARELKAAIKGAGTDEGALIEILCSRSNAQILAIKQAYKTLFKSDLEKDIMSDTSGHFKRLLVSQLAAGRDESGSVDPDTAAQDAKELFEAGANKLGTDESTFNRILSLRGYAQLKAVFEAYQQNHGKDIEAVIQAETSGYLEDGYLAIVRIAKNPPAYFAQRLHKSMKGAGTKDSTLIRVVASRSERLFGKTLGSFIKGDTSGDYKKLLLALCAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTR2</accession>
    <name>A0ABY7FTR2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_037925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR24256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="282" mass="31786" checksum="CB67F808F832C0AC" modified="2025-10-08" version="1">MTDSCATQSYDTVTDHFINQDWEMLNAVLQTSQVEGSHTGENIAEILKDCQKLSVLQLVFIFLLEKQMIVYASTPTLIGHKLKLINDVPTRWNSSMVMLKRLSEQRAAIMAIASDDNLKINKTTCNNLRSYCLTFEEHSIVEGLINVLSPFEKATTILCAENSPTMNKVLVCMAKTNKILEIESMTTGSEYEAIPLMAALLNPDTKSLSFLSAHEQEAAHRLLLDKALALIDENGRTFKLSPMLTKPLLCLTFQALQAQGEVYLIWKNLHLTWNQYQKRSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FV13</accession>
    <name>A0ABY7FV13_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YTX2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_038352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="235" mass="27270" checksum="1CE7667EE8A19F68" modified="2025-10-08" version="1" fragment="single">MAYRICPLNVNGIRDKIKHHNTIEIEINTENVARGPGLWMFNTRLLNDTEYVSPIKHNKTSYASCSEWWKLSKIKIRAITLEYSQLKNRSKTNIKKLEQTLSELLSEVLTPEIIEKISNIKQLIADYYDSNLEKQRGKNKLWHHIKTDSGTIKYGIDSILLNSEGTDSVSMGRLINKLPTKLSESDKDKLESNLNITELDNVIKTFKRGKSPGEDGMTAEWYQFFWDIIREDFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVK5</accession>
    <name>A0ABY7FVK5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNM1L-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_010796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="6">
        <location>
            <begin position="13"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="5">
        <location>
            <begin position="538"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="475"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR25092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="646" mass="72799" checksum="0D86701794234B28" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWL2</accession>
    <name>A0ABY7FWL2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_012089</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="102"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR26385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="176" mass="19765" checksum="2619FD7E06F48528" modified="2025-10-08" version="1" fragment="single">MPSYKLTYFNGRGRGEISRLLFAAAGKAFEDNRIEFANWGGLKKDTPQGTLPVLEIDGKRKISQSLAIARFLAREFKNSQCVGILKDFKLLDANRKKVEQQPKIKEYLAKRPGRAEVSRLLLAAAGKAFEDVRVDFAQWGDLKKDMPQGTLPVLEVDGKMKISQSGSIARYLAREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWT1</accession>
    <name>A0ABY7FWT1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="174" mass="18923" checksum="07F24DC72DA4D197" modified="2025-10-08" version="1">MSNIFQDADRCLWCWSMSVRCGQEAELDMDGQNSTACTDQSMPPGGNSDIGEDTEADDIMHGTRSIYLLIVVGGVIALPAVTVVRICWARKLQKARRRIYREVEDGAETDGRGVDIFAISHGAIVPCTSPPSYEQSVADPDLGKPPAYDDLPPVYAEIRRTGKHTTSGNHGNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWY8</accession>
    <name>A0ABY7FWY8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_011488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR25784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="75" mass="8893" checksum="205E0BC1DA3C4443" modified="2025-10-08" version="1">MNYKTIYIYLIHSLGCDRLNDRIIPDGLKIQLSQMYGKIILWIVGDRPSHIRLHFVYIKNLVMISYSILFNEGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXM0</accession>
    <name>A0ABY7FXM0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S41A2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_012654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR26950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="257" mass="27801" checksum="6433B9AD9154D4D0" modified="2025-10-08" version="1">MSRPGRENFQYTLRSRKSRMVPYIKPDGHTLSSSVTMEEISQDDLNSQSAVQALAKDHANGKEKRVYRTKYGLVNSVPGSIDGKVDTVGEITKQTDNIGAHNSGLTELESLEEERSGANDKTQETSFINAGNGDTQPLLQSSGSEGEEGETIIGVKLEDSSETSLQIMLQVTLPYIIAGFGMVAAGMVLDTVQHWPVFVEVSEIFVLVPALLGLKGNLEMTLASRLSTQAQAIVVGFLASMFAMVMGWIPEGKFNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXY1</accession>
    <name>A0ABY7FXY1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DPF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_011448</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd15619">
        <property type="entry name" value="PHD1_d4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025750">
        <property type="entry name" value="DPF1-3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF5">
        <property type="entry name" value="D4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14051">
        <property type="entry name" value="DPF1-3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="157"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR25744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="287" mass="33022" checksum="441622B37F4271EE" modified="2025-10-08" version="1">MKNDRKMRLPFLDSQTGVAQSHTDLWHSYRHRRPGKYPGQIYSYPERRWKKKRHYFLFPEERNNKTGDIETGEADMHQISTVENPAATSKADEEIPDLKSETSKDKWYDEYDEYMEPPDAGEMCDDQEVLCPDDNQRIKAKLALKLLRGEDGKVQNSNYCDFCLGDSDENKKTGESEQLVSCSDCGRSGHPTCLQFTANMTVSVKKYPWQCIECKSCGLCGTSENDEQLLFCDDCDRGYHMYCLNPPLAEAPEVCAGIFIQHFLNHNLHFITDLYFIISNNTVCLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYM2</accession>
    <name>A0ABY7FYM2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_011846</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF164">
        <property type="entry name" value="MAM DOMAIN-CONTAINING GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045740423" description="Ig-like domain-containing protein" evidence="6">
        <location>
            <begin position="25"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="144"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR26142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="248" mass="27564" checksum="F0E70E6C5FB5EA9D" modified="2025-10-08" version="1">MDRKVEVLPMVVLLLNVLTTICRGEHLRLNPALSYLVKAEGDKLQLECIHEYNVTAQGSAYFAKNGKMLTLDNEDDYIITSKTTIINTGLGTKVIKTLIKDSTTLTDNGTFVCKAGNFEISINVIVFQALSDIGSYNCSANFYPKTEDEQTLFLTSVYLNAGPRILNIECINQFPLTLKCNVAGYPQPNVTWEQDGNQLKSTIDSFDVLMGESVIVHNKNYSGTYTCLATNEHPPYNASDEIHIKGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYY4</accession>
    <name>A0ABY7FYY4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ACT2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd10169">
        <property type="entry name" value="ASKHA_NBD_actin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR26123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="406" mass="45286" checksum="3672D62C33D0B806" modified="2025-10-08" version="1" fragment="single">SGGRDKPSDSLQLMGGKVDELGPRVLGVDDGRGKYLMVRVPTDHEYGQWKVALESQTADNVKATYVRPAPASMPNPKKVYFPSVVAVNKESGHIVVGPDAFKPEVRHTSDVVYPIQPTNKVDKFNIDMSVMTAILKKVFTDLKVDPTHYMVMLSTPQPLGQKLQERLMRILVDELHMRGACMVQQALLALYSYNAMSGIIVDIGERLDIMPIYEGVLIEGGVSRQAYGGAKIQDSLHIALLENRYRFNTPVERPLACYVAEDYKAAKTQCDKDPASSVDLDYACFKSPEGFFNTEMWEMDYKNLQKQIFHAIQQCPMDSRKHMYRSIYLSGGVTMVPGFADRLQQELVKLAPPSVVVEVHASPQRYHSAYIGACSVASMDIFEQSCVSAEEWKKLGVKACSKWGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZM8</accession>
    <name>A0ABY7FZM8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="209" mass="23992" checksum="E2A5585D279347B0" modified="2025-10-08" version="1">MDRTIVLCCMLAIGAVFVAIRFNQRDVLSHTESAQSVTFQTSGKQLTLLWILDNIGYYRENVFNGYHCQLRWTLHDDDSATLVLRFRDGKELGATCKKFEIGGKLTRGDHAMFDLEMTFPEPLGHVTPRYWLMSDHPDDYVLLFGCINPAQVRDGVCYGRWYVDFFVTSDPPDHPPMHLVVEELYRKLGLTLDNPGFRFLNIGHACPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G036</accession>
    <name>A0ABY7G036_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IF4E2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF76">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E CLASS II 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="151" mass="17249" checksum="DA02188A34FED196" modified="2025-10-08" version="1">MKTESMYTVVKKMKPGPGENPLQYNYGFWYSRKSQGNKSASYDQNLKLIGTFASDNANKNGGKWIIRLKKGLASRCWENLILAMLGEQFMEDILSLWNRTASDGVTTSRIRDTLKRILNLPPNTIMEYKTHGDSLKSVILRLIVYLFFSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2A9</accession>
    <name>A0ABY7G2A9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="202" mass="22345" checksum="DCCA4A78B3719324" modified="2025-10-08" version="1">MYSTDKPINTVQLNPIMSGNQTSFNLTCGVEDVCKFYKMRFMANGNRVDGSTMKCLSSYSGQGGYSITCSDIVGGDKIREATNSLTCQTYDEAKPSLNTEEIVVQEEEFKFTPCCGLLENKHVLCDDIIHGSCDEHNNCTGICEFFTNCVNEKYINTDCDEKCGLPGLNTWCRGKNNKLVTDRSRPNDLCEAIVIDGNNGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2E9</accession>
    <name>A0ABY7G2E9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCYB2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF13">
        <property type="entry name" value="SOLUBLE GUANYLATE CYCLASE GCY-32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme NO-binding" evidence="1">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="291" mass="34120" checksum="0C8F048A3A453F43" modified="2025-10-08" version="1">MGIAKTHTSLPKEPLLEMIGEYYLTYLEKRGFDEMLRNLGHNVLEFLQNLDSVHVLIRRDYPDMVAPSFRCDEDSSSDRMVLHYYSKREGLHSILEMSVVSIETIKVSEENGFREHVTFDVTAKKIKEQIIEEGPPTFIAQTKKHSEKQILKEKLEQIRLQLGENALPLNRKTSVQARWKIAAKITAMHRGFVPNYPETLAINPRMFIEMFPYHMLMPSIRSRQAVLSDFFQVRWPSCVDLNYENIGRFVLCPFILEFRRDAMEREWNDRPALQLKDIEDLIYYDSSSLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4P0</accession>
    <name>A0ABY7G4P0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GIGA6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF15">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="11"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="168"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="558" mass="62928" checksum="A5BB1B202CC34B24" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4Q1</accession>
    <name>A0ABY7G4Q1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RUSC2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_002975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd17685">
        <property type="entry name" value="RUN_RUSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="2">
        <location>
            <begin position="1155"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1364"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1463"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1506"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1585"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="659"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1372"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1463"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1474"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1506"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1536"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1610"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1658"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1688"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1717"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR29407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1743" mass="191354" checksum="86A566C1144DD97C" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4Z0</accession>
    <name>A0ABY7G4Z0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="112" mass="12726" checksum="570E4556C92296D0" modified="2025-10-08" version="1">MFGMLKNLKKKVPFGKKDADTLHNGDEMAGRESYEASEPSKGPLPHDNDSWCLNELPPEISLPVVSELTLRCMFLLILSQVYGTVIWNSSVIFHQNNPSCKWMVCNIRNLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G586</accession>
    <name>A0ABY7G586_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_014193</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR28489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="299" mass="34670" checksum="59091C2DDE470394" modified="2025-10-08" version="1" fragment="single">MVIKCAVLGCSNRKDREKDFQYYRLPAIVSNQGEECEKLSSERRREWLANMNQCFKNKNLDNVRICSEHFVSGKKADLYDRTNPDWCPTLWLGGSNPEPVVSTPLHSATPHVDRYKRVQERSKRKRLELIQNDEESTFESSDSGCEGVASQTDMDGIFINSMDSEIRRLREENLKLKKDNVVRLSKEDFEGNCEKVKHLTGLSTFALLMTLFSYLEPHLQPSGVLDQFRMMILTLMRLRLNLSVLFLSYEFGISQSSVSRIFSSVIDTMFVCMGTCRNYMQYSYVCMGTCRNYMQYSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7A4</accession>
    <name>A0ABY7G7A4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Novel STAND NTPase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049050">
        <property type="entry name" value="nSTAND3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20720">
        <property type="entry name" value="nSTAND3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Novel STAND NTPase 3" evidence="2">
        <location>
            <begin position="419"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR30307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="731" mass="83076" checksum="61D7F93C64055893" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7S3</accession>
    <name>A0ABY7G7S3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YM012-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="604"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="641"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="665"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="698"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="737"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="818"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="845"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="880" mass="94170" checksum="0F47D3862C91325C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G852</accession>
    <name>A0ABY7G852_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LCK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_013150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="76"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR27446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="383" mass="44724" checksum="FEB4A95EB723A348" modified="2025-10-08" version="1" fragment="single">TTEAQYAGKICLEPYRRPKALPCLHSFCEHCLSDYVRRNSGSRSGYFACPMCRKEDNFILLSLSDTLHEDDSGEIWQKDGYPLSPPRSLAPPTPLEVQLRQYDRNASEEWLLSSGYPKGSFLVRQGEASPDTLTLSVRDCDELRGYLVKHYKILTRRQNRTEYFFITPKRMFDSMSEMVEHYLESADGLCCRLSQVCSKPRSLSWAQDRGKEDDYSTHRDTVTLVRRLGSGQFADVWEEAHRIHYKLRPILDNKPGLGKVDLQSMHLKAEDGTQIMTNKSYMTNRFTCEKFSLRLKDMCSLFYIDIHVMICIRIVVTYKKMGMNKVHCVCTACKEYLTVFDHHKEFRKQMASHLLNSIEIFQTEPENMRKNLNKLWKSEDWNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GCZ7</accession>
    <name>A0ABY7GCZ7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HS12B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="278" mass="31074" checksum="20B0016024708CBF" modified="2025-10-08" version="1">MADVVKDSVYGESVVYKSPDKLRVPWDIVKTWFDKSVDNTKNHVKHLLEKPNIRGVETIILVGGFVESTYVQERFREALGDKRIIIPSEPGLAVLKGAVKFGHNPAVVASRMMDYTYGVRGDLAFDPKKHKEENKMVKNGGNVLAKDCFVKFCSINQEVLFGQEFKRKSRGKSDIKKSSRLLIYRSRDSSPVTVSDSACEKIGRLTISYSEEDIENDDFKIETSFSFGDTELLVKRMMLKSGKEPGTSTVSGLKRKRSTPTWRKTGSMPAGGSFGASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GEM6</accession>
    <name>A0ABY7GEM6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR29651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="564" mass="64633" checksum="255B5022F5904FCE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GFB8</accession>
    <name>A0ABY7GFB8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IF44L-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_034163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFI44 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241:SF32">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="3"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR31621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="504" mass="55965" checksum="66A7F3158E08E268" modified="2025-10-08" version="1">MASKMKSKLTEAEMDVLEIMIGSGPKTFTLLYSITRDGCNATTFHQKCDNQGATLTVLYNPQGSVYGGYAGFNWPGPGVWANDSKSFLFQLKFSGKKKERRFNNKNFTYSYYGSNNHGPYFGNGDLITFSGTINPSKGVFVLNGSSASATYDIHGLQADDITNGNLNVTELEVYKVTDGARRIVLTKPWRRTPDWNEKFLCELTKEMENMSPVIETLNAYRILLLGPVGSGKSSFCNTLTSVFRGRITQRAICGSGNRSTTTLYQPYNIRTRQGSDLKMLICDTRGLEEHPGIGPIDVNFLVDGHVPDMYEFNPEIPIDLSVPEFQLKPSLSQKVHCVAFTLDAASLDDIPSNVMTKIIDIANICKRKQIPQAILLTKIDTIDETVDGSVKQTFDSWKIHEHVKKASKLLGLTENLVLPVKNYSSESMVDDDVNILALLALRQIVYFVEDHLENVHMTESISVRRMQTANSDSGNRTDSGVDDIPLNVMAKVSNSNGKSNKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBM0</accession>
    <name>A0ABY7DBM0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DHSO-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_007154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="47"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="210"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="353"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ94683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="457" mass="49774" checksum="9B9B53FA56B3896D" modified="2025-10-08" version="1">MKYKFVKNVTSPIDQLNTFVLGVTHNNTAAGKSCDATEIASSSMVRDVRLSMKTVGLCGSDTYMYKNASHGSHPITEPTPVGHEASGVVAESIVVLLKMNHPAPRTQKSQIHICKAVLGRDRVALEPGAACHKCKSCLRGQPSVCLVEQTYLGRGLEVGYIRREHVMKADYCHRLPAEISDEEGAFMEPLAVAVHDCRRGEVGAGKSVLILGADIIESRLKLAKELGATHTLLTTSRDLESIAKQIHDVMGEMPDVTLECSANNFCLRIAVAATVPSGCVVLVGYGEHECTFPIAEVVEKQIDLRPCFRYDRYPIAIDLIKYGRLNVKPLITHRFPLKSTSAAMEKSASREPDIIESRLKLAKELGATHTLLTSSRDLESIAKQIHDVMGEMPDVTLECSANNFCLRIAVAATVPSGCVVLVGYGEHECTFPIVEVVEKQIDLRPMVDVREVSGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBV0</accession>
    <name>A0ABY7DBV0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YGCC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053127">
        <property type="entry name" value="Chromatin_remod_comp_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37929">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN PFC0235W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37929:SF1">
        <property type="entry name" value="SWI_SNF GLOBAL TRANSCRIPTION ACTIVATOR COMPLEX SUBUNIT SNF59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="266" mass="26963" checksum="FD36E548781A02AA" modified="2025-10-08" version="1">MGDNLNTPANATGENLNTPANTMRDNLNTAANTTGANLNTPATTMGANLNTAANTTEDNLNTAANTTGDNLNTAANTMGDNLNTAANTMGDNLNTAANTMGDNLNTAANTMGDNLNTPANTMGDNLNTAVNTMGDNLNTAANTMGDNLNTAANTMGDNLNTAANTMGDNLNTPANTMGDNLNTPANTMGDNLNTAANTMGDNLNTAANTMGDNLNTAANTMGDNLNTAANTMGDNLNTPANTMGDNLNTTANTMGAYLNTTANTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DC72</accession>
    <name>A0ABY7DC72_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CALRL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_006776</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF42">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR SEB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ94305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="269" mass="30816" checksum="16C8AA556AF95A0F" modified="2025-10-08" version="1" fragment="single">MQIRGARHKETHIQLRVQKRIKLHICLFLSFIFASLVTVTWDVAVYLDRLQNERANTVMHRNSAGCKLLYILTRYVSTANFFWMFCEGFYLHRLIVHAFSPPKTLIPYYLIGWVGAWIPSLIYSVVRATKQEYDSRKALKATFVLVPLFGLQQFLVIYRPPPGTTLSFTYEILQKVIQNTQGATVALIFCFFNGEVYTYMRNCIGSHINIGSSSKHHNRKNSMSSATQITSYTSSARRNTKCHNNSDKSYTPLSAISTTQELTIPTNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DD61</accession>
    <name>A0ABY7DD61_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ERN2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_006756</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="58"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="5">
        <location>
            <begin position="302"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ94285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="435" mass="50206" checksum="0F588AAE09B0D120" modified="2025-10-08" version="1" fragment="single">KVNFIMETKILLERINDIVDHFVFSSVSKHAKLWPNIQDTTICGPCKYKIVKIGRITFNRENVIGKGVEGTVYRGTFARERVVKVNENLLNVTCANIVRFYYFDENKFSFYLCMELCDCNLEVFICQYPKEVPKDGFKQILEGLKVLHNNKFLHRDLKPSNVLVKKEKTEEGKLIVLKLSDFSLAKETDDEMSVISGLYIGTEGWIPPEIHQGTEVKPSNIVVNASADIFACGMLGYYVVSGGQMLYNSQEAINHDINQGNADYSNLHDPTTKDIVRAMTCRDESKRPNAKMCLKHPCHWDSARVFEYFKVVNDTIVSVDVHIKTQVSNALNQNPHQVFQSDWKSRLTPLVKNELFTAPRSSTRPKYNEFNVTDLIRAIRNTKEHFLQMKHLHNELGNNKNDLHAYWTGLFPYLLIHTYTTLKPMTMYGELQHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDN0</accession>
    <name>A0ABY7DDN0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GALDH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="133" mass="14838" checksum="6E976696BA887055" modified="2025-10-08" version="1">MSPVLSAVWWGASSFGSVFRSTDDSESVRVLETAIRSGVNLVDVAPWYGHGKAESVLGKVHDMEFAPSLDLIINETLPALQKVKDAGKARFIGITGYPLENFRYMKPLHNRNWEGIEVANYWKQINELKSPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDP2</accession>
    <name>A0ABY7DDP2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_028099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ95409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="142" mass="16561" checksum="8A72050B3AF68B62" modified="2025-10-08" version="1">MVQLFYYETRGKCCKKFLNHEGVPTKIHLFPYEGWAQPAMTSYWLLKTYWWSRSRVKITEVTGSQRHEVKGKVQCIKNGSIVISGKIKDRTNSDYRMYLTSNVDSADFQLGYCVTGTLERGRKKSEKGLSLTHYAMIKRRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFL7</accession>
    <name>A0ABY7DFL7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_029156</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="14">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAQ96466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="127" mass="13389" checksum="465795913A455346" modified="2025-10-08" version="1">MPGGKAGKDSGKAKAKAVSRSARAGLQFPVGRIHRHLKNRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGTQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGQ9</accession>
    <name>A0ABY7DGQ9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="223" mass="25631" checksum="C5A5213D0C735596" modified="2025-10-08" version="1" fragment="single">MSPEQRYSVKFCVLMAWIYECHSTFKKDPTRDAVDDPRAGRPNSASGKADEIGTLLRGNGLFQSKRLLHQNKTSHGINEDKHASRSTETQITSPKLLVDDNLTLKHPIDSILNAHFLDDLPCEVGFQQEYEVDFPTEKTASPKIPHVIHQIWITTSENMTTSSHQMVPAQFIDNMKTFRKFNPSWEYMFWSYANGRSLVERFYPNVLDYFDKAPESVTKSDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGR3</accession>
    <name>A0ABY7DGR3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RAC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_029557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ96867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="161" mass="18157" checksum="BC46FA55856F47C1" modified="2025-10-08" version="1">MKQIKCVAVGDDLDEYKAVKSVDDSDYKMNLFDTAGAADYDRLRPLSYPMTDVILLCFSLISKSSYESVPSKWVPEVRYHCTGTPIILVGTKVDARETFSDRSKKVTYQQGRQLKELVGARYYVECSALTKMGIVEVFQDAVRAAITPPVKRRGNDRCKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHF5</accession>
    <name>A0ABY7DHF5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_029799</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Chromosome</location>
            <location evidence="12">Centromere</location>
            <location evidence="12">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the SPC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.570">
        <property type="entry name" value="Ncd80 complex, Spc24 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 12" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 12" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAQ97109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="188" mass="22229" checksum="CEB5C4E9B4C2A263" modified="2025-10-08" version="1">MESVDEFLEVADEFMQQESLNIARAREQISVVKQNVLLIETLRRALEDQIKTDIEELISDKQESQQSLLKQEQQLRQEMESVKRKNMELSAGLAEREQEKAGLKEEREQLSEERERQENETKVNIPIRKEEISLYTCISKIRWDFNTPKHEVKGYVSRKGSVKPFCFDNRKTSQFFITNALWDAMQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIM7</accession>
    <name>A0ABY7DIM7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ERYA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_030182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050444">
        <property type="entry name" value="Polyketide_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681:SF8">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681">
        <property type="entry name" value="POLYKETIDE SYNTHASE 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="5">
        <location>
            <begin position="4"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="6">
        <location>
            <begin position="886"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="4">
        <location>
            <begin position="886"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1030"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="4">
        <location>
            <position position="928"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="4">
        <location>
            <position position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ97492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1412" mass="157112" checksum="1819900D6ADBBD1D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKC3</accession>
    <name>A0ABY7DKC3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SVEP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_022517</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="71"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF4">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="67"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="81"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="77"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="43"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="4793"/>
            <end position="4816"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="34"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="251"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="310"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="474"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="565"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="655"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="762"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="877"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="951"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="1101"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="1211"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="1321"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="1431"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="1490"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="1597"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="1679"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="1801"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="1882"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="1965"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="2077"/>
            <end position="2134"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="2218"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="2383"/>
            <end position="2440"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="2557"/>
            <end position="2614"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="2667"/>
            <end position="2724"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="2770"/>
            <end position="2827"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="2881"/>
            <end position="2938"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="2993"/>
            <end position="3050"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="3180"/>
            <end position="3237"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="3291"/>
            <end position="3348"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="3403"/>
            <end position="3460"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="3569"/>
            <end position="3626"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="3647"/>
            <end position="3682"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="3736"/>
            <end position="3792"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="3816"/>
            <end position="3848"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="3902"/>
            <end position="3958"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="3960"/>
            <end position="4015"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="4070"/>
            <end position="4127"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="4170"/>
            <end position="4227"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="4266"/>
            <end position="4328"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="4330"/>
            <end position="4424"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="4439"/>
            <end position="4496"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="4520"/>
            <end position="4552"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="4606"/>
            <end position="4662"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="4717"/>
            <end position="4774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="4861"/>
            <end position="4882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="5021"/>
            <end position="5088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="4866"/>
            <end position="4877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="5051"/>
            <end position="5062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="5068"/>
            <end position="5078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="5079"/>
            <end position="5088"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="683"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="764"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="793"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="905"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1129"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1239"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1459"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1515"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1625"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1719"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1829"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1885"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1993"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="2105"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="2246"/>
            <end position="2273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="2411"/>
            <end position="2438"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="2585"/>
            <end position="2612"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="2695"/>
            <end position="2722"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="2798"/>
            <end position="2825"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="2909"/>
            <end position="2936"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="3021"/>
            <end position="3048"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="3208"/>
            <end position="3235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="3319"/>
            <end position="3346"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="3431"/>
            <end position="3458"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="3597"/>
            <end position="3624"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="3653"/>
            <end position="3680"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="3763"/>
            <end position="3790"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="3819"/>
            <end position="3846"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="4098"/>
            <end position="4125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="4198"/>
            <end position="4225"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="4467"/>
            <end position="4494"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="4523"/>
            <end position="4550"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="4745"/>
            <end position="4772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ98144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="5088" mass="529282" checksum="A886708B7E1EA10C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLW3</accession>
    <name>A0ABY7DLW3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KPRB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_030370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF53">
        <property type="entry name" value="GH23275P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ97680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="354" mass="39473" checksum="BB9795EC96066434" modified="2025-10-08" version="1">MTMPGEKCPMVLVSGNSHPELAQMIAEKLSAHLLDCCCYNKANRETCVEIKESVRGKDVYIIQTGTKDVNNDMMELQILAYACKTSCARNVVGVIPYLPYSKQSKMRKRGSIVCKLLAKMLSRSGLTHIITIDLHQKEIQGFFDIPVDNLRASPFLIEYIQSTIPDFRNAVIVARNPNSVKRVTSFAERLRLSIAVIHGEEKDDDEPIDGRTSPPRHVHGEASAFNPIPAMQAKEKPPLNVVGDVGGRIAIIVDDMIDDVQSFVAISAVLKERGAYKIYAMATHGLLSSDAPRLIEDSYIDEVVVTNTVPHEIQKMQCNKIKTVDISGMLVEAIRRIHNKESMAFLFRYIGMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DN70</accession>
    <name>A0ABY7DN70_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondria-eating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_022503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031981">
        <property type="entry name" value="MIEAP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16026">
        <property type="entry name" value="MIEAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondria-eating protein C-terminal" evidence="2">
        <location>
            <begin position="84"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ98130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="212" mass="23844" checksum="78337E1EF7199E0A" modified="2025-10-08" version="1">MKFKELFEDKWTDAFSILTASKGLKDDEGIEILLKLLKATDDESGPTLSAPAWSRGGGDPKVGQSHVSREAVQQNLAGNPSTKAVDQKQQLCLQQQQEQKKQKHQEHDGHDEMGKSIVRKIIRNLKFQKALLNHKEITILVVQCLRLCCLMQAQYPPMVLDFSFRCGDVFHTDALDAFSTRGPTMAYLVWPPLRLHKDGPLVCKGYAEGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNB3</accession>
    <name>A0ABY7DNB3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_029175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ96485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="303" mass="34491" checksum="3AC0694B20588594" modified="2025-10-08" version="1">MADPKFDPFWKELGTYFEEWSVVKERKSSSTSYLPLAISVEDLRKRVLQKLPDDTPAPSVSWIRLNFMPSNQLTSSAQHYTGKFDVKALVAGNQPSLQCLDHDFHLAGIVSSDCLNVDIPESPRDSSYKGTVHVSVKYKVFQPSSPLRHAAENHNIVLNNYTDDGVNFDKRILFRYTDGGPDHRTTFKSVKTACLLKFISLDLDMMVCVSTAPNQSYNNPAERKMLKKCGSDTCEYCTLNPLRVPKEVFDDLHFFPDPVPDGNDDNHYKKFQNARGYVKCYECGKRRVVYVAKKLSNLRNNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQW0</accession>
    <name>A0ABY7DQW0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ENKD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_030030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027012">
        <property type="entry name" value="Enkurin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052102">
        <property type="entry name" value="Enkurin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490:SF2">
        <property type="entry name" value="ENKURIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490">
        <property type="entry name" value="ENKURIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13864">
        <property type="entry name" value="Enkurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51665">
        <property type="entry name" value="ENKURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enkurin" evidence="7">
        <location>
            <begin position="62"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ97340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1417" mass="160716" checksum="E45992285ED415B8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DR52</accession>
    <name>A0ABY7DR52_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7042 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_024267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055470">
        <property type="entry name" value="DUF7042"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23069">
        <property type="entry name" value="DUF7042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7042" evidence="3">
        <location>
            <begin position="28"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ99894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="584" mass="63278" checksum="CB42C39296DBDD31" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DT35</accession>
    <name>A0ABY7DT35_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GOGA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_024431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051952">
        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF24">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="646"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR00059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="808" mass="92629" checksum="33B8C9825DC32B77" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTR0</accession>
    <name>A0ABY7DTR0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_024599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="257"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="MIB/HERC2" evidence="3">
        <location>
            <begin position="519"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR00227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="78564" checksum="77256A3221A1CB44" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTS0</accession>
    <name>A0ABY7DTS0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MOT5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_007675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="63"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR01117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="437" mass="47557" checksum="C78336CB09BE3185" modified="2025-10-08" version="1">MDIPSVAGISGATSYEINDCKSNFSSSGRSECSIESSESFKQRMKEASSEHTISKIEDTEGGWSWIVTFAAFMFYFLVDGVSFSFGVFYVELLETFNASSWATSWIVSVMLGTYLLVGPLVGALVNKFGCRTVASAGSFVAAIAFFACTYAPSIKSMIIVYGFVGGIGIGMMYITPVVAVEEYFVKRNALAVGIAFSGCGIGTFALPPLMEYLISVYSWRGAMQIMAAIVLNGVPLGFLLQPGFVKKPANIEDKNIADGEEAMPKEDENKTGFCRFLPTFNVDLLRSPTFVLFGVFNCLCIFGYFIPFAFLPAFGQSKGFSSQKSSLLVSTIGISSTISVLISGWVSDQTWANPIFIYSVAAFVGGVATVLVPFYPSYLTLILYCIIFGICLGALYDKLENYVGTFFFSGFTMVLAGILTLQILWIQKLENRGKQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZK9</accession>
    <name>A0ABY7DZK9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="143" mass="17180" checksum="2B70FBAD6D45FF3A" modified="2025-10-08" version="1">MTERTHVHNLVMVNVMDFVNMWNIVNGRPVQRSKTDLDTLRKTWTELKHVQLLDTRQQEEERSWDQEFSKRKNELEQQQHISSKKRIQNKARLADISARWRSLERKRLEKSEFYLERFRTSLSLAASRQEAMSYGSPAVSFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0X5</accession>
    <name>A0ABY7E0X5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046094080" evidence="1">
        <location>
            <begin position="21"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="363" mass="40592" checksum="6E7E69B2ADF1ECE4" modified="2025-10-08" version="1">MISVHGYILLSFLLLLMANGMIVCERGVRAPRQKYAMYVWTDGFDKGVSGCGLSEFLAWDSRGPCFTHTWNTAEKRAWLWNTCNLPGREVSAIFVSDVHHNLKRAKETGDCSSADISTVRLMLSEGHSQVPNLKIYGLYAVSDLAVSERSLVQYIVHYNDHCARNPNERFDGVAVNNEAYAGIKCKSDAERTQYLHALAEITLEAGKQTNGRLLTHYSMGWHWGICDGAPSDITWRGNTYNANHHMIDIFDSTDVQVGYIIHPQIADRMRHAGYDHALAAGKPIYTTVYTNRATSLCQTSFFPDNTCHVHGHSEAAMFERFDDFSNNGIAHALPCIHYFRGIYSAGAHPDWPSHHSGHSPIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E119</accession>
    <name>A0ABY7E119_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PPE21-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR03695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1189" mass="128571" checksum="63BEFBE6B237FFEC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E227</accession>
    <name>A0ABY7E227_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NCEH1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_009037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="227"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="428"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR02479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="523" mass="59108" checksum="8322D32B791544D9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2C7</accession>
    <name>A0ABY7E2C7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="265" mass="28639" checksum="43C587641F3F5157" modified="2025-10-08" version="1">MVVGLQLTVAVTTYYTFTSTFYSSVALLAWYHGYTPTATAIIAGMSAVERELQHILPLPNLPGLKPLRHEHQHILPLPNPPRRRPLRRELQRILSLPNPHGRRPLRRGVIPITPRPFGQPAGGLGADRRTSFFAPSGTGNAEATSPMSAELVSTVVVVDVLMVVSMVVVVVDVLIVVSMVVVVVVDVQMVVSTVMVNVMMVVSTVVVVDVLMVLSTVVVNMLMQGSTVVVNVLMLGSTVVVDVLMVVSTVVVDVLMVVSMVVWMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E348</accession>
    <name>A0ABY7E348_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PGA18-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="951"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1138"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1273"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1448"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1473"/>
            <end position="1486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1514" mass="167796" checksum="0D65C31F06A31540" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3I9</accession>
    <name>A0ABY7E3I9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">USH1C-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_010089</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd06737">
        <property type="entry name" value="PDZ1_harmonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030237">
        <property type="entry name" value="Harmonin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051844">
        <property type="entry name" value="USH2_Complex_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116:SF36">
        <property type="entry name" value="HARMONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116">
        <property type="entry name" value="PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21219">
        <property type="entry name" value="USH1C_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="104"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="224"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="617"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="421"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="515"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="537"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR03531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="718" mass="80875" checksum="F3DAD73ED6D857EC" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3J4</accession>
    <name>A0ABY7E3J4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_009926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR03368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="342" mass="37515" checksum="D2BB56B41935AA1E" modified="2025-10-08" version="1">MRSAQKQHVNDVGNGVRSALSLFLTVLAVILLCGGFVSPGWIYLDSSDESQHVGLWYTVSCDRNTPTGQRECETFSLLHWSTGILALIPVGQKGNHVRKLSKDSSNVSFPYSLFLFGVGGVLLFVVSLILFFDIMFSYQKRKSYGKLVSLKNGSGNHLNHSKEPAKKTHFVYEQSYVSGQDQADGKVVHKKYEVPVVVTNTTTRNSYQKPASVNASSQQNTSVKQQEIILSPTAYTAQQIAKTPSPTIQVAPNYTASSIKAATYTPTKSREVIRTTSSSPTREKTRTLSTSPTWKRQQAEALAGNTLVITSKRPSSKLKLHTSGKKSSTNFTSKHYLSVGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E417</accession>
    <name>A0ABY7E417_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WFD18-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_020114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00003">
        <property type="entry name" value="4DISULPHCORE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047116020" evidence="1">
        <location>
            <begin position="22"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="3">
        <location>
            <begin position="80"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="2">
        <location>
            <begin position="132"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR04745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="198" mass="21223" checksum="489DA7408C333D6D" modified="2025-10-08" version="1">MSLPTVLISAVLALVLTSVYAAPSPPLDCAAAACLIPDCPEGEKCFHTDGKTYAHGETFKDKCNSCVCRDGSVACTKIGCIAKAGECPTPWPFGKCTSIHMCTGDWECPNEQKCCRNGCGKVCRIPITTTTHRCYRRGVWYNDGETLPSKTSDPCLQCRCQRGVITCEPVMCLACVGIKRPGTCCPECGIVPWKAGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E446</accession>
    <name>A0ABY7E446_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AIP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_010542</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039663">
        <property type="entry name" value="AIP/AIPL1/TTC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056277">
        <property type="entry name" value="PPIase_AIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242:SF0">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23322">
        <property type="entry name" value="PPIase_AIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="AIP/AIPL N-terminal FKBP-type PPIase" evidence="5">
        <location>
            <begin position="35"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR03984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="324" mass="37081" checksum="A17F42DF2C7731ED" modified="2025-10-08" version="1">MADIFAALEKLGIYKKVLHAGVGDNPDYEDGTKTTKCDDERTVIDDSHRYDKPMEIILGKKFKLEVWEALLKTMRPKEVAEFTVDKKHLEQYALVSKQLREIFGKEKGEVKESHCCGMMAMSEQGLGHPDLDDLVKSPQPLIFTLEAINVERAGSFEKEVWTLSDEEKLGKLPRLRETGNELFKQKKYAQAADKYAEAIGILEQLSMKEKPGDPEWQELEDQKTPFLLNFAQCKLSLGDFYPVIEHTTTVLKRDADNVKALFRRAKAHVGAWNPEEARNDYERVAQLDSSLANTVKKELAHIDRLQKERNLEDKKKLQGLFINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E507</accession>
    <name>A0ABY7E507_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_008789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR02231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="320" mass="36077" checksum="C30D30FA300F2BB9" modified="2025-10-08" version="1" fragment="single">MEDIEVNIKTNRIEFNSCCTSLFENKTPISSVIRNPDLVVAIDVGSTYSGYAWQWRSAFNANKASVEFNTDWGQGAPQLHKTNTALLLKRTFDRTAETSVENPAKIKTEIVAFGYAAERRWANICGDPDQKKDRDSYYLYKKFKLQLYQLKQDQYEGDVNIEDADGRRDSLKEIMTFFIQALREDFLKKVTTRGLNLEDVKILWVVTVPAIWSEKAKKFMRDAAEKSGIGKKNLLLASEPEAATIYCLNLPSEQKAAMEDAFNPGHRFLTVDLGGGTADLLAVEIQKDGSLKELCCDQGQLVGGQNVNEAFLQSCHENFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5F1</accession>
    <name>A0ABY7E5F1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="7">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">E3 ubiquitin-protein ligase TRAF6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">MAR_010575</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">MELC-2E11</strain>
            <tissue evidence="23">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TNF receptor-associated factor family. A subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="7"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR04017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd16643">
        <property type="entry name" value="mRING-HC-C3HC3D_TRAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012227">
        <property type="entry name" value="TNF_rcpt-assoc_TRAF_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049342">
        <property type="entry name" value="TRAF1-6_MATH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027139">
        <property type="entry name" value="TRAF6_RING-HC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF152">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21355">
        <property type="entry name" value="TRAF-mep_MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015614">
        <property type="entry name" value="TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="15 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="69"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="22">
        <location>
            <begin position="131"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="22">
        <location>
            <begin position="186"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="21">
        <location>
            <begin position="491"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="18">
        <location>
            <begin position="131"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="18">
        <location>
            <begin position="186"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="381"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="WAR04017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="644" mass="72145" checksum="AAFB3F2E2AED32A2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E654</accession>
    <name>A0ABY7E654_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NUP88-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_009194</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019321">
        <property type="entry name" value="Nucleoporin_Nup88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10168">
        <property type="entry name" value="Nup88"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="529"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR02636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="678" mass="76567" checksum="86789B33828D98E7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E944</accession>
    <name>A0ABY7E944_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="366" mass="40949" checksum="198F83AF72CE927C" modified="2025-10-08" version="1" fragment="single">MDKGPVYPGQTRSQLAFASVVQPEARSSPHLALGMTWFPKGGRIVGTQYQSYWHLFVLQEARQLQVKDIPRTARLLDTSKGVHCLSSFHTPLFKISFLLSITSLFKITFLLSITSLFKITSLLSIHYLSSFHTSLFKIAFLLSITSLFKITFLLSITSLFKITSLLSITSLFKIAFLLSITSLFKIAFLLSTTSLFKIAFLLSITSLFKIAFLLSITSLFKITFLLSITSLFKISFLLSITSLFKITFLLSITSLFKITSLLSIHYLSSFHTSLFKIAFLLSITSLFKIAFLLSITSLFKITSLLSILPTSSSQTADEPSKKQVMFLSLTFVSRTYPISHDTRTGGSETDPFVALMYIFGPAVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBQ5</accession>
    <name>A0ABY7EBQ5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_021690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="587"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="728"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="821"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="919"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1204"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="728"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="821"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="934"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="977"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1001"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1247"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1261"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1315"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1336"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1358"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1385"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR06321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1447" mass="161885" checksum="22C18125F61CC0C9" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ED17</accession>
    <name>A0ABY7ED17_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein bS6m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">28S ribosomal protein S6, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_016957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR06999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="128" mass="14880" checksum="0E9F8237E0B0ECCB" modified="2025-10-08" version="1">MPPYEMALVLRNAANMKLLKESLKGACKQIWEQGGLIKKVENLGKRELPHPTNYFCIQFDNSVDGMRQVEHKLRNADEVVKFGIIGRREENQRPCQIGQCLFGELPHPEHERHAYKKRVLKKFKAKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEK5</accession>
    <name>A0ABY7EEK5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_018268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047155298" evidence="3">
        <location>
            <begin position="18"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR08310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="217" mass="23013" checksum="9028B5ECC7E15A2A" modified="2025-10-08" version="1" fragment="single">MKAVVFFMLSFFAATSSITSDESTGVSTSVVTPTDSAVTFSTSVVTPTVSAVTFCTSVVTPTVSAVTFSTSVVTPTVSAVTTETQSSTQSEEATSSPLSVVSRKSVPASVIAGPIGVIIFIVVVTIGLVVFFRQRKRRYDAKYICNIHYNQAYDEHGAPSADNVSASSKDSGFGKHESVEGEMMDGDYNTLRLHFPVNNGPQGNTSNRMDEYLTADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEM2</accession>
    <name>A0ABY7EEM2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_017239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR07281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="485" mass="55866" checksum="4F7A2E8898082F69" modified="2025-10-08" version="1">MAKSRSEIQKAYRERQKAKGSAFLEKEKVRQRGYYKPAFTLLERKGVERNSKNKLRNRLSRMRKQQQHDVLSQVNETSGYESGTPQGTQQELQELSRLIVRLPTYSNKSRGIKTVKARALARSNKKVRQLKELNASLRKKLKVRNRKISRISKKLNEVKHNTTVNSTPKKRTEADLQSLKLTPKSKQAIRRKLLLSNTVMSEIKSAQESTSAKRRQGLYCIVSGRIARKYRCLNQIQRQTGLSRKSLAKVMDKKLVNITHSESRLCIARNLKSQVIEFLSRDDNSRSQPGKADAKKTESGEKKQTRVLTDYVGNLYDKFLKPWNKTTFQRLRPKNILLTSFISRNTCQCVHHQNMALKIQSLRKLDIKIGQNPEHLIARLDELDNILENLPENVNFKTWKKVESEGKMRMKVIEQNIDCNTFRQDIKQQLKAFVEHSGARWNYFEVGHGKGPCDGLGGTVKRMADDAIKQDTLSYKTLKNSSNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEP9</accession>
    <name>A0ABY7EEP9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6570 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_017189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="2">
        <location>
            <begin position="162"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR07231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="532" mass="60937" checksum="F9EA6C7B5DD11BFD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EF52</accession>
    <name>A0ABY7EF52_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_017648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045661957" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="23"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="205"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR07690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="334" mass="37172" checksum="FB5610700DF129B9" modified="2025-10-08" version="1">MDVTLLAFVIGCVSLGSVSFADPPASRLHMTPDLPEAYFLQGDPLRISCTLIYAHFRSPGDNAVLPSFFRDGQEILDTSTAVKVYEVGVASWVNSSLTIFSKEARPEHSGNYSCTTPLFHMDAQISVHVVEVTATNAELPATESVPHLDLKYRLYNYPTTDYSVSATCTDADGNAIGQHGSHGHRYRVGKALPDIVLRIASPTGPKVVLRESQITVQGGDPLEVECDVTGYPLPDVIWRKNERELVVDDRWSQRHSQQNPLLVHVQIQVDRLIKMFESTTKGNNDNAAYTCQMEMAKILSVMDTIKDTVKDGFITTFTELAEIKEFRKRHSDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EG08</accession>
    <name>A0ABY7EG08_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">M3K7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_017684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46716">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46716:SF1">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="286"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="392"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR07726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="582" mass="64071" checksum="62D6EB1E7D5FA27F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGA8</accession>
    <name>A0ABY7EGA8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="62" mass="7149" checksum="3841DC3FA39056F6" modified="2025-10-08" version="1" fragment="single">VWAMNHDYTIFLSPVGNGRETNLLITMLSHTKGDNCDNKKMDQKQLTYPEIGFKGFLGYMHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGT8</accession>
    <name>A0ABY7EGT8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">MYO6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_019171</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd21759">
        <property type="entry name" value="CBD_MYO6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01382">
        <property type="entry name" value="MYSc_Myo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21958">
        <property type="entry name" value="MyUb_Myo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049016">
        <property type="entry name" value="MYO6_lever"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032412">
        <property type="entry name" value="Myosin-VI_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036114">
        <property type="entry name" value="MYSc_Myo6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF745">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21521">
        <property type="entry name" value="MYO6_lever"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16521">
        <property type="entry name" value="Myosin-VI_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 11" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="14">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="13">
        <location>
            <begin position="57"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="13">
        <location>
            <begin position="595"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="853"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="881"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1008"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="881"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1016"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="151"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR09213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1171" mass="135325" checksum="2522C13436218F4F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHP2</accession>
    <name>A0ABY7EHP2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SYT10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF252">
        <property type="entry name" value="SYNAPTOTAGMIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="203" mass="22230" checksum="3786EBDC36409428" modified="2025-10-08" version="1">MSDVGIAMLVVALIVVAVVLLAVLIRIFGVYRITSCFATSEEKAVLTKNEQYNGYMVGSESSEITADRGAGKYVEYDTLQTDPRYVDLESHSPPREESARSSPVSIGTGSMASDAEFGHGIKRAESCDSVASDSSVLEMQPDMPKFGQLEFALEYDREVSELVVSVIQARDLTANQYTGTLDTYIRGMIQPAEAEFKLQTKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJL0</accession>
    <name>A0ABY7EJL0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_017349</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="11">
        <location>
            <begin position="139"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="467"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="825"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="18"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="185"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="317"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR07391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1002" mass="113229" checksum="909C300855D81C77" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJU8</accession>
    <name>A0ABY7EJU8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ICA69-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024114">
        <property type="entry name" value="Islet_autoAg_Ica1/Ica1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164:SF4">
        <property type="entry name" value="GH23156P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164">
        <property type="entry name" value="ISLET CELL AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="1">
        <location>
            <begin position="49"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="387" mass="45068" checksum="7EB9F80F9B565697" modified="2025-10-08" version="1">MESHGYSGSNYDRFVENRETSTFHKFKETFWTTKQAVIQKLGKKEDEHVFKAIQKSCMELLRAIEKYQDRLCALSMEENATGRFLKANSGQDKTRAGKMMAAVGKSQSFSAQQRLALRVPLVRLYQEVETFRYRAISDTLMTINRMEGARTEYRGALLWMKDVSEQLDPDTYKQLEKFRKVQAQVKKTKARFDKLKLDVMQKIDLLAASRCNMFSHVLANYQSSLLHFWEKTSRTMTAVAESFKGYQYYEFNIIKELQEPSKHLSENTREPAERDIIPDDFDPEKYLEEEDSRKKENCDKCRDINDRLVTLEEDPEEEAREETSLQNLMAETHAMNQAGLPKELQSGDNQSMQNFLEFGTEATESMESLKLLPVPKKQHKQNLNHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EK92</accession>
    <name>A0ABY7EK92_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="8">PPIase</shortName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_019330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="157"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="263"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR09372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="381" mass="44024" checksum="283801C31D25B412" modified="2025-10-08" version="1">MLSDCIILCCKNFLKLCKIKYYNFCLFHSVQRNLVAQTGDPTGTGKGGESIYGLLYGEQAKYFDMENVPRMKHKTIGTVSMVNNGGHMHGSQFFITLGAGLDYLDGKHTVFGEVAEGDDVLAKSGRIGMDEDIDEFEGKTEVEVGDLPEEDCAPPENVLFVCKLNPVTTDEDLEIIFSRFGAIKSCEVIRDHKTKESLQYAFIEFEDEKSCENAYFKMDNVLIDDRRIHVDFSQSVSKITWKGKGRYRRYDLVFDEGETVQQSKKKKKKKAKLRESSSEEEQHKASKPKKHKKRVSRSPERPLSKKKHRDVSSSPERKSKFHFNMVYDNKYKAKFKKFSANYYHNNQFYLYLQTESRFTNGILNLFIYLYFEMHTSIIGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKJ9</accession>
    <name>A0ABY7EKJ9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HARB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_018887</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF292">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="108"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR08929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="220" mass="25398" checksum="A5446FBF25D3D3B4" modified="2025-10-08" version="1" fragment="single">VIRWPTPQQQVDIARYIEDKCALPGVVGFVDGCHIRLSSALKGDPSMHLQIKNSDKMSFEAAVVDHEMRITHVYTGWPGCVHDARRQKLDNLSFMIIIFWRTVRIHARNWLKTPFKNFGNLTPQQTRFNRTLSSVRSTVERAFGHLNCRFRRLQNVPFHNSEDICKLIYAACILHNLCLLHEDDVEGYIQEDNDPNNLANVYANGHIGVVRRLRLVNLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKV3</accession>
    <name>A0ABY7EKV3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="91" mass="10184" checksum="12F77AF68F3AB4BE" modified="2025-10-08" version="1">MEPFLTSTCLQEVKQKGLNIERLTMDGDSTTCTRVKPSSFPDLKKSNDKNHINCFSYRISQNKGNTHGIKTSLKALSAHVLNEHSSCSPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EL28</accession>
    <name>A0ABY7EL28_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_035763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPIN/STSY family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.70">
        <property type="entry name" value="Spindlin/Ssty"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003671">
        <property type="entry name" value="SPIN/Ssty"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042567">
        <property type="entry name" value="SPIN/Ssty_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF25">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02513">
        <property type="entry name" value="Spin-Ssty"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="129"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR10687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="746" mass="85470" checksum="637CB5FA2E34DAC4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMH5</accession>
    <name>A0ABY7EMH5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046880422" evidence="1">
        <location>
            <begin position="20"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="293" mass="32687" checksum="F304771D73F29DAB" modified="2025-10-08" version="1">MSRIFTFCMLAIVIQVSQAASLKFEKESIQITTDAQGPSFICKKGVCKLCANPSKTDTVCIVATDRGRKIRPGTRSICSRKNPLPNIDQICIIPKDVDIAKLHSCLDVSIKVNETTYRQSIGCFTIPKKNFLDRIVCVIAKALHNAMTVELVSNRFVIVKGKITNNTDVSFCKKYLDARTFCIVARNINMKDKIFNALDIQRIGCFKIPNNVDEMQTYGALDSDDINVEPDNIDSKIIDAVADSFGSDDEHVEFDTVELDAFSPFGAEDNVPTTRLQKLMLTFLKSLQQQTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EML6</accession>
    <name>A0ABY7EML6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CHRD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_018384</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039790">
        <property type="entry name" value="CHRD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983:SF3">
        <property type="entry name" value="CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="98"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR08426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="194" mass="21686" checksum="E3081BA72405DF30" modified="2025-10-08" version="1">MKGWSCCKKRSTDFTEFLNTPMMKQKIEVGEVERPPVDEPITRLPVSVAPSLEKAFEKALQQMTLQAADTTNTGNGETEVKVGTQCKNTGCQAIEDTKKNCRMDWFQTGPNINISVFSKLPAPDQTYVEVNRITCHIHITFEGGKSIFNQTLILRNAIIPGQSSVKLLGTKVEIMLRKAEAFSWPSLEYKEPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMX4</accession>
    <name>A0ABY7EMX4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="41154" checksum="D827D5189FD2CB1C" modified="2025-10-08" version="1">MRCNSDDLAHYMQASYSHASMHIFITLSAVAVFIGTRHVFSKIRNEMANLTVIIIGAGPIGLTSALIAVQCKRVHRLVIFEEENRSRVENRSYQITIQPSLVSFLRGYGVDFDNLEGEWQDGCFYTRVGVYLEYIIHVLPLYRAETDIKFGTKFSRDCIDTIDVMSGRKLVLCCDGRTGLAGQILGLSDECAYHSTASFGALAAIERSSQTLVPKPEIRVHNIGFDLSAYVSSELEEKSKSTFSLKIFGNSRCRFLALAVKKSDTKIVKAMKTVLDKSKTETAAYISDCDTFVITEGDASRSFNFNTGMDINLGLKSLSSLKPFIERITVAETEYNIMSSLIYKMEHSDRICKYFLKYGLKEYLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQG9</accession>
    <name>A0ABY7EQG9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAPEP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="246" mass="27724" checksum="3CFE3CE21F3B9BC4" modified="2025-10-08" version="1" fragment="single">AIPKVHPVMDYASRKVQNPPQDKIQITWIGHATVLVQIEGLNILADPVSYTRFRPPACEAKDLPPIDVVIISHNHHDHLDSQSVWDIAELYPDAKWLVRSGNAKFCKMHGCKDVKEMKWWEPTTVGACTFVCAMVWMGCEKPKYKYYFSGDSGYQDELFKLIGQKYGPFDLALIPIVQCEAFFCGYITKFVSMNPEEAVKVHLDIPSCVSIGINRGTFELTNEVYLTVCSIVISGAGFISIEFKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERG4</accession>
    <name>A0ABY7ERG4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OX2R-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_026770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000204">
        <property type="entry name" value="Orexin_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01064">
        <property type="entry name" value="OREXINR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR12590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="194" mass="21753" checksum="B8287D5F43AC303D" modified="2025-10-08" version="1" fragment="single">MESILRNLTHFAEENITISFRNKSDNISETVQSKPCKSRYSSLDEIADCFFPEPEEWVLIAGYVITFIVGVLGNVLVCFSVWRNREMRTTTNIFMVNLSVADLTVLLLLLPTALVADVTETWLIGTTMCKLSISLGTMCISVSILTLCAISIERWYAICRPLSFHSSFQRARIIIAAIWAVSMCVALPEFLALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWK1</accession>
    <name>A0ABY7EWK1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNAT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF1">
        <property type="entry name" value="AT07410P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="185"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="279" mass="32048" checksum="5CDA6F921EC4046A" modified="2025-10-08" version="1">MVSRAQTYKNQSLAFKLIKAAIDMIRYLDIPAVHIKREASPNCSKMIFYDNAGYKELSYQPLETFYSGRTHGARLVRITEEFYECALDVVRKYFILEEPVNKAVGMQWTDELRELWLSSFRLHLSIAAVNEVDGDIMAIRTTRITRKTDFVDPGTFQNQGLKRLFLIFNHCDQKADFFNRFGITEALHFYGLGCADKYQHQGLASKLFKAAIDMVRYLDIPDVYITGEATSNYSKKIYENAGFVELFEQSFATFKVKGEVVVPNTGIHKSMKKYGLKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZM0</accession>
    <name>A0ABY7EZM0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="103" mass="11801" checksum="2FDDC5A34F122F40" modified="2025-10-08" version="1">MEIGEFTPFGKTTNKWSKNGSKWRRATISFNQTSQKCDMFSFDYDLTINMCGWAELRQGTDGEINLNGIPWDKVSADLKLLKTKTFDDSSVRYAWLGPECSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0T0</accession>
    <name>A0ABY7F0T0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_005890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045701191" description="Protein sleepless" evidence="3">
        <location>
            <begin position="25"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR15785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="12855" checksum="232A100EAF83B4CE" modified="2025-10-08" version="1">MAKLFVAFAVLGMMLVINTQSVAAIECYVCTLTGCGDEFDASASGVTKTTGCASCTKGKVQDVVTRGCSQLSASDNCEKADVAGQEVVSCTCTGELCNSATTMRIALPFTVAVLLFHLITKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F147</accession>
    <name>A0ABY7F147_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15324" checksum="D0E0C7852B5BC849" modified="2025-10-08" version="1" fragment="single">LRFREGASDRKIEHNMRQFVVLVLTVFGMDVVCVSGKSFHYLESAQKFGQDNLCKTYDQRQMLQRAILGKVCSSSDTGIINDDFIMYVVHTLCKDTGGWLADWVLKHVDMDGDGRVSHFEENMFYNDYELSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1E1</accession>
    <name>A0ABY7F1E1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ACT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="127" mass="13887" checksum="226423774CE61C76" modified="2025-10-08" version="1" fragment="single">ISLVCTFTLRRNKTFHGRRVIGLVSACDHDVRPELLKNVIVSGGASMPLGVVDTITSSLRRSVTSGTGITVVAPPERKKSTWLGGSVLASLSTFPEFCKSRRDYQEHGVSYFDSFCDGEILDKHVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1H5</accession>
    <name>A0ABY7F1H5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="231" mass="25815" checksum="1C4DA2498EA57B5A" modified="2025-10-08" version="1">MQDAVITYTRSSVETCKKCVADDCAYCTINPPRIPEELFKELYFVPDSTVNANGYTPFDELYGTETDDSGRPSLTLKPQSTGETRSFVNFSLGQRKLPVQQQHQTQQKKHHKYPHAKKGPSQEPCAGSDENRLDEEDNSTSDANVADKNGLTELTSELKKTRSAVPKDLSLRVDSGQNKKKKLSLSLRKKKLRKTFSQFNDTSTNIDTETLGESSGQTLNGFVDSLNKQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1J8</accession>
    <name>A0ABY7F1J8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="166" mass="19158" checksum="C5CEF26696DB77E6" modified="2025-10-08" version="1">MVHEICETAIVLREAVSAADLVLQDVQKLTSLQETRGMSLPVQRETGDIKIAWGNFCWRYSAFMPGKPVRYSSRTSVKVSCSRWWKELVTLSSIAEEMRVGKKKSWTLIPDSSSKMPIRYITSRSLTADHTLPDEENKMDHRRLVDECNWMYHNMTCALCWIGIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1Z5</accession>
    <name>A0ABY7F1Z5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PSUG-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_030797</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="7">
        <location>
            <begin position="482"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR16203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="722" mass="78396" checksum="3630AA4022D77A46" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2M7</accession>
    <name>A0ABY7F2M7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G protein-coupled receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26375" checksum="5CDED5D19D32E9AB" modified="2025-10-08" version="1">MPLYGLDNGLFYYFHVTSIVCLTLSIILSTRISSFRSHPDANSFTGWTKGERIAVYLSLCDLLLNISILMNHLHILIPKTLFRPKELCSFVLVHHDRIRAFSDSDGQRCSINVFTTMFFSTNYTFGKFDSGILLWSFGVPFIGALIAAILDKFGPVGIACFFEAINGRVAYLVLITIPITTILVVNVGLYILTFIKIRIYVRAIRQNIGNIASTVGSHIRAARNMSMFVVAFFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F6J1</accession>
    <name>A0ABY7F6J1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CRBL2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_032406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. ATF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd14709">
        <property type="entry name" value="bZIP_CREBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039250">
        <property type="entry name" value="CREBL2/REPTOR-BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21051">
        <property type="entry name" value="CAMP-RESPONSIVE ELEMENT-BINDING PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21051:SF4">
        <property type="entry name" value="CAMP-RESPONSIVE ELEMENT-BINDING PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="58"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR17812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="133" mass="15578" checksum="4E11DDD2877AC39A" modified="2025-10-08" version="1">MNNTEDLDSKLQIIESPQHQEEQTEQPGPSEMSGDRPARRAGRRPGRKTAKMDVRAKLERSRQSARECRARKKLRYQYLEDLVANREKAVFALREEMEMWKNLCTEIDEGRSAENLKEKLLKTCDNQQVKTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7Y8</accession>
    <name>A0ABY7F7Y8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="199" mass="22271" checksum="F0151147D78F6924" modified="2025-10-08" version="1" fragment="single">MMVSKGQNNELQERSPSDDSQQGYQSPNAVTSNTDRQLNGQNNELQERSPSDDSQQGYQSPNAVTSNTDRQLNGQNDEQQERSPPVMMVSKGQNNELQERSPSDDSQQGYQSPNAVTSNTDRQLNGQNDEQQERSPPVMMVSKGQNDEMQERSPSDDSQQGYQSPNAVTSNTDRQLRLNSVDMTIYQPEKSDIDLGLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8I2</accession>
    <name>A0ABY7F8I2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CALM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_031582</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR16988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="142" mass="16368" checksum="AF61183D407F612C" modified="2025-10-08" version="1">MAILVAVSSPACNKKPKQEDGETTMDKENGRIEFQEFFKFMQAEMTKLNEADFTNNQDTVRSAFRTFDKDGNGYIDEKELRIAMKKLGEALTDKELDDMMKEADVDEDGKINYEGIGVKVLCYVIVMKFDFKEFVKIWCETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9Z3</accession>
    <name>A0ABY7F9Z3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylhydrolase ARH1</fullName>
            <ecNumber evidence="4">3.2.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ADP-ribose-L-arginine cleaving enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">[Protein ADP-ribosylarginine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_000835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically acts as an arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.19" evidence="4"/>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012108">
        <property type="entry name" value="ADP-ribosylarg_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF26">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016939">
        <property type="entry name" value="ADP_ribslarg_hdr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR18997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="356" mass="39577" checksum="A79305CBD423D9BF" modified="2025-10-08" version="1">MMYQACMVLSGAGDALGYKNGDWEFCHHGEEIHWQLQELGGLENIQVDTEEWIVSDDTVMHIATAEGIVQVQGRTGDALYRAIAAKYKECVEDMAGRAPGATCVGNALKLEPEMENGYRIPFNRHGGGCGAAMRAMCIGLMYPRTEDLNKLIEVSIESGRMTHNHPTGYLGALASALFTSYSLQMKPVKEWGKGLIETLPAAWKYIEDTGLDLDQNKKHWGYFTERWVEYLKVRKIEDGESVPSFPQKYGVNERDAFYKACAFRGKGGSSGHDAPMIVLDAFLGYDGTWIDLCNRAMFHGGDNDSTGVIAGACYGAMHGFKGVPKGNYENLEYRERLEKLALNLLKLSHPEEYTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FA01</accession>
    <name>A0ABY7FA01_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="509" mass="56941" checksum="3280535540932E60" modified="2025-10-08" version="1">MEMSMQMTGKERRQYSDWKTERDRVDNARVERARNNGEWRPGRIGSGRFDRGERDERQRGDAPGTMKGVDNEVKEKPGVGRGRGRGRGRGRGRGRAKDRTRTNSDEGRRVENNNDLLVIKFDNTPGREGESSVEVEYSDSETPIITTRKPGQRPHSIAGHPTTPGDKDELWWDEDFEDIPLTSTEPDNADAHIEEILSDPHDEYHDSQENGEFIEDGQFEDTDGYRGNVKRSQQVSQGDTDEWEDCETEESWGTGTQESTDSASNKGSKIPKHSLSPDDALRLHMKNLNPDAPVFTPTSPLSPLSPDVMKTPEGHVKVADWAAAMKTPVTSPENISFNSASPVSKEESPANPKGTKTEGTSQGLPRRIEKDFVSPNKADQNDEEKSSESDKNKTAEMKTDRSDVSKSKESENDSKEKESDTKVDSEESESSSKTEEANKIDSNENETTAEKADGETPEDKGEDISEENLQCQKTLLKSRWPQKPLKNQGLALQRRRGPPKKRQGTLRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FB05</accession>
    <name>A0ABY7FB05_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="83" mass="9433" checksum="8E37C23FF8EB3139" modified="2025-10-08" version="1" fragment="single">MAIVRGAAQSNLFDSFYQYNIQFRLCMANDPLMSWSNIDDFNYKGGCFKSFCKYANTCMACKAVHPLVKCTRSCPQSVAPVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FB59</accession>
    <name>A0ABY7FB59_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="518" mass="57802" checksum="F6112B3A2E4284B6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDL0</accession>
    <name>A0ABY7FDL0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_000641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR18803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="85" mass="9645" checksum="BFE98B434F2147BD" modified="2025-10-08" version="1">MYDEALKSVKAAESAYVNRATVLELLDKLRESCKKSNRRFDFTTLNNEEYVDLTGLTKAAFEDIAIVLKDTSAITRSEMSTRLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFI2</accession>
    <name>A0ABY7FFI2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="68" mass="7569" checksum="0AD7B1D69F8681C9" modified="2025-10-08" version="1">MGLKGITMLSSKPPHIPHCREAVSKGSSFLSGGHKVFLRVFPRLSVGSVTMLELLASYKHTKRKIYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGB0</accession>
    <name>A0ABY7FGB0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="13314" checksum="0F0C9E853E295EAB" modified="2025-10-08" version="1">MTDTFMVNQGKMADTFMVNHCKITDTFMVNQGKMADTFMVNHGKITDTFMVNQGKMADTFMVNHCKITDTFMVNQGKMADTFMVNQGKMADTFMVKHGKLANLKKRWTCYDWRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJ01</accession>
    <name>A0ABY7FJ01_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015103</name>
        <name evidence="1" type="ORF">MAR_018079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="113" mass="13156" checksum="18AC2F5892A31DB5" modified="2025-10-08" version="1" fragment="single">VSMDLLEAVREAGVVVDILRAERMDETVFDAIFQKAADIASEFQIDASVPRQNQRQRNRANYQVEDPKTYWRIALYNVFVDHLIEEVSSRVMANQERFCAQLLLPVRLRDLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJ51</accession>
    <name>A0ABY7FJ51_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ZFAN4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_014682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd01802">
        <property type="entry name" value="Ubl_ZFAND4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053061">
        <property type="entry name" value="AN1-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46728">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46728:SF1">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="517"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="286"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR20708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="577" mass="63529" checksum="592552C3E7ECA940" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FK14</accession>
    <name>A0ABY7FK14_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">STX18-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_016384</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd15850">
        <property type="entry name" value="SNARE_syntaxin18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="SNARE-complex protein Syntaxin-18 N-terminal" evidence="12">
        <location>
            <begin position="27"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR22410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="238" mass="27256" checksum="03629189DF610A4B" modified="2025-10-08" version="1">MPTPTGSPREKRRKHSSSPTFVDNMADLTNLFKATVKTVKSRNKGLRKSSDKDEASQIFPQSKNRGEFESTTKEVVRIGHIGTITKLRDFLLEHRKDYVNAGSHLTGEASQMTNTEREHIDNEAQNILRRCQDMLANFEQENKAMYAEMNSLSEELSKIQGKVVEIASLQEIFTDKVLTQEEDIVRIADTAVFTTENIKDGNEEIREAMRKNAGFRVWILFFLLVLTFSLLFLDWYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLV9</accession>
    <name>A0ABY7FLV9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="129" mass="14501" checksum="36DDAEAFB1AA9117" modified="2025-10-08" version="1">MHNNPLKRKAAPKPPMTSVGCVVMSFSCKRTCVGLDDLMDSVHGREVMASFCKRTFVRGFQFFNVDFKLKEIIVAKMAVCQSSHCLSGRNSYSVFEANKKKRKLMYCGSPLHDVKGSDDCLVEKLLSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNT0</accession>
    <name>A0ABY7FNT0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_037552</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR23883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="258" mass="29676" checksum="887D196269E0B4BC" modified="2025-10-08" version="1">MESVDFLLFGLAILIFSGWCFNLPGISILKPLVGIDPNLFENLESFFKMKYPNFELLFCIQDEMDASRMIVQSLIDKYPKVGEMWESTLKSTTWRSVDEDTLVDMAVYMTPNVGLVHQMPYTCTRKGLASTYEKVYFGTQHAKMYLSANVLGINCAVGMSCLMRKPILEEAGGLHEFGQYLAEDFFIAQAFLDRGWRTKKGSIPFSKVDYLVCWCLNEISYPLLMLQSHWDPIITWRGRNFKLKWGGLVEELYVKQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FS95</accession>
    <name>A0ABY7FS95_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AMPO-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_038554</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033577">
        <property type="entry name" value="AOPep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46627">
        <property type="entry name" value="AMINOPEPTIDASE O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46627:SF1">
        <property type="entry name" value="AMINOPEPTIDASE O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="10">
        <location>
            <begin position="230"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="8">
        <location>
            <begin position="378"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="9">
        <location>
            <begin position="563"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR24885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="636" mass="72539" checksum="DFE36295523BFCA5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSW5</accession>
    <name>A0ABY7FSW5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_038043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="105" mass="12273" checksum="86A82BA457DBA465" modified="2025-10-08" version="1">MDLLPFTDCIGSRRRYLSENADVSGSNRLPSYYTSDVHVSDIETNYRQRRTLSLRSRSDKCDEPRTMKRGLWNKELRNRFRNLGTSLKMNWREGGREAGREGGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTQ4</accession>
    <name>A0ABY7FTQ4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IFI44-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241:SF32">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="58"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="315" mass="35256" checksum="38429089E16DD132" modified="2025-10-08" version="1">MHIFANRRRPYQEEHVLEWKQPSGVAETSGMERQAKLKDEVTIAKPLVGLDVSHFRFLLLGPIGSGKSSFINTVNAAISGRVTQRASCGTSHHSVTTTYTPYTYRNCSGSSLHLKLCDTPGLEPTQGIDVTDCRFLLNGHVPEFYTFNPSVHFGLDSHEFRVKSTADAKVHCAVFVIDASTVDHMSEKLVDTMTSFKKIMFEKGVPQAVLLTKIDTVSDTVDEDVSRVFNCADIEQKVKKASEVLGLPRNSVFPVKNYEHEIDGDRNVDILALVALRQLLYFAMDYLENQKMQQNKTGDSVRLQCGLWCVPAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYA6</accession>
    <name>A0ABY7FYA6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PRRT3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_011520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059081">
        <property type="entry name" value="PRRT3-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052836">
        <property type="entry name" value="PRRT_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35578:SF6">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35578">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25987">
        <property type="entry name" value="PRRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="557"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="594"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="690"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Proline-rich transmembrane protein 3/4" evidence="9">
        <location>
            <begin position="466"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="296"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="870"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="960"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1051"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="405"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1084"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1112"/>
            <end position="1128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR25816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1128" mass="122758" checksum="CFD6A6A4334188DE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZF4</accession>
    <name>A0ABY7FZF4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="391" mass="43707" checksum="DEB249EF2962D634" modified="2025-10-08" version="1">MTMDLHALQRQYASLRKKQKKHTQVIIRESVKDVKESSMLTNQLASSPLATKTEVKTIIDPITIATISMDTGTSSNAFLDSITPQVVGDTKCILVQQAKHKDRKKHKHHETHGGNTTEPTHTDYEGLLRNLKLEMASSRKVRGRSLSVPSAIKEENEYSEDAKVSDERKTSVDNSSGVTYGKTCQLTLKSLSLSDIPSSKDKAAEEHTIKSENISAKTEEINGNPSNINTEVDNVCNANDSIEKHVMAEQKPDGRVNTEQDETKNTTSSVFSGIEAINDGSMCKQKPSGRLLYNGKFPLPKRLQRSMSANLESTLRKTGLKVNPEIKANIYHHFYTKKRHLSADLGLSAYIDDNTHKIMNPFPVQHWNENRFKAGMKLGLYKQRKSSDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0I4</accession>
    <name>A0ABY7G0I4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MSPD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039283">
        <property type="entry name" value="MOSPD1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34441:SF1">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34441">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="126" mass="14236" checksum="9DD18F411906585B" modified="2025-10-08" version="1" fragment="single">MYNPSTALAEGKLPVFVFPTSLTFYSDDQATHKQVLTLYNPYEFPLNVIRHTDICINNEGMNDKFRIQVSEHGQRKILDTQTTVPNQGVTGLVCIVALMLPQQGETTSRLPDYLHLSHNQKLIAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2T6</accession>
    <name>A0ABY7G2T6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="507" mass="57340" checksum="DB0B648426B94263" modified="2025-10-08" version="1">MVETLEKADEENCVNSNGEIGIDDSVVGYAYLLIDTCHTGDSSVDTSGLLNNSVEMVSCRSESFSPVSSKTTGRIYYNSFCAQCNEQKRAVPWQMIILQMRPLTSYELAVMTNEDINDMFPQRLYTPPEGEDWTSKECVSVVDSCNSSNTTLQALCKTYYAPITRASWPTSRPYKNVFCAMCNGLSEERLLNESVCLQSSAKTSSLTNTGTILDVLHYNMRQTQSDKQTSKPETACSDHESTCYPVFCPRGMYRTDSQRCVYFGEKWVINPKLMLTLMKYSGPSLGLALSKMKPLQLVKLLQIPKQCHDIGWTDMSILGDTIPKTVEQETETFEVVLLKNSDGLGIIPETFFPNAKSCLTEEWTMVIQKQKIVLKAFLKKQLNQNLITMPRDRISYELLDKLYFCEQIYLPKDEVMKTPQGLLINSTGAFLYPSEFSSLTRLRSEDRILYVYLVAVCVDDFIETSLDIVNNGGHLVFCLGQYCCLLFCVTIFVLHESAVFQYTVEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2Y7</accession>
    <name>A0ABY7G2Y7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_014526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33504:SF1">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 90, MEMBER A1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33504">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE) 1 BETA SUBCOMPLEX, 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046015545" evidence="2">
        <location>
            <begin position="21"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR28822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="595" mass="67597" checksum="F9804FCB20B66BF7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G472</accession>
    <name>A0ABY7G472_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_013883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595:SF1">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="410"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR28179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="761" mass="81265" checksum="1171DC541CAE07D9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G555</accession>
    <name>A0ABY7G555_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="151" mass="17470" checksum="718BDAC1F9789702" modified="2025-10-08" version="1" fragment="single">GSCFRIVHTELIVTWATSTVAGKSEEHKSSETFEELPKTIIIRHLKGGYEYENKIYTEVVNHGLGCRIVSDMFSEWQFANPNTVPCVVIHKGVKLNNERLEHHIKTVWQVLLIDSKAAEQVHTMMIGLRYRMHTVNLENIRWSQNLLQQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G664</accession>
    <name>A0ABY7G664_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ZN233-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_003500</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF5">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 44 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR29932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="133" mass="15630" checksum="5C69DF9629266D1B" modified="2025-10-08" version="1">MRDAIQKHMRIHTGEKPFKCDTCNAVFAQSCTLQKHMRIHAGVKPFNCEICDFAFTRKQHLLDHMRRHTREKPYKCETCGVAFTLKPNLQSHMRIHTGVRPYKCEKCGVAFTQSHENSHRSEALQMCEMRCFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6G0</accession>
    <name>A0ABY7G6G0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="87" mass="10093" checksum="F9479B4CBA0D3DE4" modified="2025-10-08" version="1">METCLKPYEIFYSQDSINNVFDRKSQHRNIRIGETLDDICDGRCSVLSTPPITVKSVGVKWITADNRRLWVLKHLERLGKLETIKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6S9</accession>
    <name>A0ABY7G6S9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_014480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046211643" evidence="3">
        <location>
            <begin position="22"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR28776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="485" mass="54490" checksum="FD31AC06B682DE6A" modified="2025-10-08" version="1">MYSLKCVIVTILYFFGEICKGQRVFVSQDDTRWDESSCTLAVPKITCKDNSSCIVENYLEFTTNEEDQDNGFWIGYAQTWISYAYLGCGHLNAGAEYFVSTLGECRRTTGCKTFGIHKSIVGLRCKCASKIDSWIQTSGEKCREVDQYPCGNTAATIFSYYTVENVPPSEHSHNIHNNCLQFFYKNRPGNDYHWESCTSNTFPNLLCSNKYFSVSHPEGTAAPLDKDKEGGSTAGLAAGLSVSLVLLITVTVIVLVFLKRRGLLTKCYTRKGEKGNRNEDTRTEISFVSTPIFESTTNTTNDLTASNHSYFVLEKTFNRETKEETEHYAEPDTTDVVDHYELTEISQKDTTNDDYDTTDGKKGPAKSGLAKSNNNYNKVTLHQSNEYDHIHQNGRPPKSDRQSEYEYDVSNNVIDGKRNDNFGDDGDTYNHLNKHESESSGTDNVYGKSATDGDSGYDTSSALKPLRNKDANDQQADYAVIKKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6Z7</accession>
    <name>A0ABY7G6Z7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="70" mass="8042" checksum="DFFA48221AFAEEB7" modified="2025-10-08" version="1">MPPVALRLGNKQRFFKSWLTYVTCGISKYGYHITLLQLFENMKMALGNHEYVATILIDMSKTFDCTTGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G741</accession>
    <name>A0ABY7G741_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053127">
        <property type="entry name" value="Chromatin_remod_comp_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37929">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN PFC0235W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37929:SF1">
        <property type="entry name" value="SWI_SNF GLOBAL TRANSCRIPTION ACTIVATOR COMPLEX SUBUNIT SNF59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="411" mass="45766" checksum="990BFE0F514227E7" modified="2025-10-08" version="1">MAKTEHIFKIYYTNIFCWRVNVTQDLESEMVTQDLESESEIVTQDLESEIVIKDLVSEIVIKDLVSESEIVTSDLVSESEIVIKDLVSEIVTQDLVSEIVIKDLVSESEIVTQDLVSESEIVTSDLVSGSEIVTRDHVSESEIVTQDHVSECEIVTKELVSESEIVTQDLVSESDIDTRDLVSESDIVTQDLVSESEIVIQDLVSESEIVTQDLVSESEIVTQDLIVTKELVSESEIVTQDHVSESEIVTKEFVSESEIVTQDHVSEIVTQDLVSESEIVTQDLVSESEIVTQDLVSESEIVTKDLVSESEIVTQDLVSESEIVTQDLVSESEIVTQDHVSESEIFTKELVSESEIVTKDLVSEIVTQDLVSESEIVTQDHVSESEIVTQDHVSESEIFTKELVSESEIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G847</accession>
    <name>A0ABY7G847_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PROHY-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF51">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="285" mass="32218" checksum="5E5D0E13CDF4BA12" modified="2025-10-08" version="1">MADMAKTGSGLFGNEFKYEEPEFRVTNELPDAAGREPKMMLWSYTGNDILGMVPRLQKVATTCEQVPDATGREPKVLLWCFEGNDILGLVPRLEKVSSTCEKLMGGDELYHYHTKIMMKDAKKGGSFEWHQDYGYWYKNGNLRPDLISMFLAVDPCIKENGGLQVLVGSHNGGRVDHTFDGGQQGADKERVEHLKKIYPHYYFNIDSIPGDCILFHCNLLHSSGPNDSAQRRWAFNCSYNKRSNNPVKKHHHPFYHKLDKGKEFVDPATDETVKAGSKGEAIEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8A9</accession>
    <name>A0ABY7G8A9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ZN233-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_002849</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR29281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="255" mass="29355" checksum="906AE8E2AC3B2AE7" modified="2025-10-08" version="1" fragment="single">SHEYAQREDHTHVRFLGLSCFEGNFKTSHENTHLRYAIHTGEKPYKCELCDAAFSQKGNLQSHKRIHTGEIPYKCDMCSAAFTHTRNLQTHIRIHTGEKPYKCEICHAAFSQKGVFQQHIRIHTGEKLYKCEICDAAFSQKATYSNAHRREAIVVGDMCCCFLSEMCITATFNNTHMREAIQKPYKCEICDAAFSMKGELQQHIRIHTGEKPYKCETCDTAFSQKGVLQTAKEICPRHQLSFSMRCSFYTLSHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9B1</accession>
    <name>A0ABY7G9B1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="64" mass="7478" checksum="008381E110389604" modified="2025-10-08" version="1">MCCHFYSKISFAKPHGNSYRKETIQESIQTSVRHVVLLVLKCWMCIAHAELTPERSHSTLNIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GA21</accession>
    <name>A0ABY7GA21_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">KIAA1217</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7527" checksum="D45E34C52849553E" modified="2025-10-08" version="1" fragment="single">VEIHSDTSSENDVVHIRTEGVQYAVVQGQPVTQRIETMQPHNDDSLTYAELDKFPTGSSRQNSVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GCS9</accession>
    <name>A0ABY7GCS9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BETA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_033308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR30766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="608" mass="68558" checksum="6992544CA16569C9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GE09</accession>
    <name>A0ABY7GE09_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="67" mass="7628" checksum="9FEDF3CBF577CA97" modified="2025-10-08" version="1" fragment="single">MHTQVERSAQYTRTTKRTKRCIRITAWATRILAILSIVYCIVAFVTLGEIEFGILLMVTAILVSTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D829</accession>
    <name>A0ABY7D829_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_006303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="270"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ93832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="357" mass="41665" checksum="AE4C2F959DCA0ABC" modified="2025-10-08" version="1">MVLLPMVPPSLANITSYGKTFSEIHHLSDEEKKSTMKSIEQWWKKYIFRGISGQEIAQEQFLNRLNQEFKSNKEEFIKDKRNYFSTILGVIDINHDKFIDQVEFVLCFRAYGHENLTADTDFFNAYKPVDGKVPVKVIVDSWTDFLTSEYSSKESIEKNAFESVQTEIDAIVSFQFAMANAFLVSKWKIWYNSLDVNHDGMISFADVEENKFSELHNLDAKQKKDVIENFEKWWNQYIFRKRKGEEISEKEFLDMLNNDFKTDKAKFLSEMEACFKTLFNVIDTNQDRSISEDEFLIAFKAYGHENVALDTKFFKSYNPDKDGLVPLMNIVNSWIQFTTSEDESKPDVVKAAFESGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D8T7</accession>
    <name>A0ABY7D8T7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ARL5B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_006164</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ93693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="151" mass="17236" checksum="81707B4A3F222013" modified="2025-10-08" version="1">MGLLFSRLWSLFTNEEHKVIIVGLDNAGKTTILYQFLMNEVVHTSPTIGSNVEEVLWKNIHFLMWDIGGQESLRASWNTYYTNTQDLRKAAVLIFANKQDIKGSMSAAEISQHLNLTSVKDHPWHIQACCALTGEGLYQGLEWITNNLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D9S6</accession>
    <name>A0ABY7D9S6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052787">
        <property type="entry name" value="MAVS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21446">
        <property type="entry name" value="DUF3504 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21446:SF12">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ93557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="205" mass="23267" checksum="C4FE8D9CC8F4E873" modified="2025-10-08" version="1">MENFGLFSLDDSLELDFLDSDDESFNTIDIGQFMINTMLNVTPVTTTVTPPAASLSQGQSLNERAADLGPTALKATPKQTEARKQAVLQFSEYHRNTLTNIRSALNRHLKDLKRDIDLVRDKAFTSANNTLNGFLKHRTSNEADLEKIRKYLELYETSAIVLRECVWYLIAIHFVTRGLEVHHQLRNDSLVVSTDDSVRERQNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBG0</accession>
    <name>A0ABY7DBG0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CERS2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_007473</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="20"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ95002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="117" mass="13925" checksum="6D0D880EFB1AD381" modified="2025-10-08" version="1" fragment="single">MAEKTKGNGFSITDRQVCRMQKPWLWQTKYCWIGWPLQNIPRDVYWYYTIEASFYWGLVFTLFSDTKRKDFTQMAVHHFATLVLIYFSWMMNLVRMGTLVLLLHDAADPILAVCTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDX6</accession>
    <name>A0ABY7DDX6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="454" mass="51202" checksum="FCE37DB34C591B49" modified="2025-10-08" version="1">MQLQFIYINCLTNLEGRISILEKKCQPRSDYMIFPTQMSLDEEQKQDEVFKQFTTQVVIINLCLSLDNYLTWKTTQPQTQADGSHIVQLMCEFIQDNIQNYPQIKQAFPDIEEKIKQLQTDTAAQEDLCAARLCCLVNSWTTRCVTSASPIADLKVQFYLINPFEILNRIHQVSSALQDYDSMSNGWPGTLLDVHSVKASCFVPDKWLGTLLDVHSVTASCFVPDKWLGTLLDVHSVTVSSLYLTNVSCFVLDKWLGTHLDVYSVTASCFVPDKWQGTHLDVYSVTVSCFVPDKWLGTHLDVHSLTASCFVLDKWLETHLDVHSLTASCFVPDKWLGTLLDVHSVTVSCFVPDKWLGTLLDVYSVTVSCFVPDKWLGTLLDVHSVTASYFVPDKWLGTLPDVHSVTASCFVPDKWQGTHLDVYSVTASCFVPDKWQGTHLDVYSVTASCFVLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DE61</accession>
    <name>A0ABY7DE61_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TRRAP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="13372" checksum="A78378E92E516249" modified="2025-10-08" version="1">MWAGLWQKRAKFSETNTAIAYEQHGFFEQAQGSYEAVNVLNDEVLYTQAMARGRADHNTGPASPPVLPEYRLWEDHWIRYMYFHFNNLPGVQIYNTQTLNGFKEENNLIINGKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DE98</accession>
    <name>A0ABY7DE98_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_028279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ95589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="225" mass="25807" checksum="E55C3797B4DACADE" modified="2025-10-08" version="1" fragment="single">SNRCPNVPENDNNHDDKHTNVIVDIRIFICVLHYIFWHKLNTVMNFFIVNLDFSDISMSVFCIPLPFIANLLINYWSFGKTNDNSAHEVINTCCHKPGHLLGNCTPLETGNDEASSMYCVMHLPTAMRAKFPQFVNDSNAPYFCEELWGNTIGHSVYNVFVPATCPILYVTYDPRVYYDKIILVLWIIKTPSQAVNYKRNERQTNYHIQKKVIEIAGNVAVVTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DH71</accession>
    <name>A0ABY7DH71_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="87" mass="9408" checksum="4F3817BB70947C86" modified="2025-10-08" version="1" fragment="single">CDIPLCSDLNVTVDNCQPTTSNGTLYERLTSDRAGFDLLSTISDVINAVSCCRKCSHIVPCVMVTYHQNTGTCTLYKENTSNAAAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHK7</accession>
    <name>A0ABY7DHK7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">H1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_029151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467:SF20">
        <property type="entry name" value="H15 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="9">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAQ96461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="202" mass="21852" checksum="C083B22704817EBE" modified="2025-10-08" version="1">MSDSETTSAAAKKPARPKPSHPTYLVMAKEAITALADRKGATVQAIVTYISGTYNLETDTVRQRLKPALARGMEEGYLVRPKDSDAKGFTGRFRLDKTKLAEEEKAKKQKEKLQAAKEKKEEAKPKAKATVAKKSPKKKADGKAVKTKAAASKAKKTPVKGKKAAAKPKVTKKPIAAKATLKTPLKTPKKLKTAASSKRRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHM9</accession>
    <name>A0ABY7DHM9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="74" mass="8317" checksum="EED9C34CB9E852EF" modified="2025-10-08" version="1" fragment="single">MTKEHVDVMAIHIDVQQPKKRGRKPKRQRGRRPGEAGDKARKAQDALHVTSFSLGRLQDKPEKDADDGSEGKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DI30</accession>
    <name>A0ABY7DI30_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047155283" evidence="1">
        <location>
            <begin position="20"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="114" mass="12819" checksum="3FDD87B9142A5F20" modified="2025-10-08" version="1">MWLLYMMAAILAGLTCLEARRYRYCSEGCCPEEYCAYKLICYPKIHCSFGCPDGSCQQEICMPAKNCTMDTECGFAHACTFNYNLGYKSCQYNLEIGKTLCVDSHGNSLLKPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKU0</accession>
    <name>A0ABY7DKU0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UBE2O-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_029896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd23837">
        <property type="entry name" value="UBCc_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057733">
        <property type="entry name" value="UBE2O-like_SH3-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057735">
        <property type="entry name" value="UBE2O-like_tSH3-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF15">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23043">
        <property type="entry name" value="SH3-B_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23046">
        <property type="entry name" value="tSH3-B_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="1056"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="600"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="971"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1258"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="971"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1295"/>
            <end position="1309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ97206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1360" mass="152351" checksum="3199E92CE480DCAD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DL38</accession>
    <name>A0ABY7DL38_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SIBA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045465651" evidence="1">
        <location>
            <begin position="17"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="477" mass="52220" checksum="460A76218D4BC960" modified="2025-10-08" version="1" fragment="single">MLKLIIILAICSVVTGSHFRGAIIMWEPDSDSLKILIHFRISWRRSFSSSYNCTDVTIASGTLIGDSSMTCFSGCSDVVGSLEFYCTDFDTTEDWTTGINTVRFTPSVSAFSFGFSSCCWINGLEAGGGSWSFKASVDLTLRSDTGLINRSPTVEMAPIVVLLQGCSYDLYLPVGDVDGDIVRCRWANAADECSGVCNVFANAVLDETACTISYTASVNGYFAVALQIEDFASTVSTVPLSSIPLQFLVHVITCSDCTCESQPEFVDPTPDANDCFAINVGDQLNLTLKARSKWPLRSLTTISPIGMVRSNVEHTSDNDWNYLSVNVSWIPTQNESGRDHNLCYYATDNNLGLSNVIRCIKIPVSVKGPTPLRVERQGVSNTWAIIIDQTFDRPTNSAFITMYESENNTALVSIDVSTSSDVVYDPIHRRITVTFNYVFDIDAKYHVSIPSGLVKGYVSCGAVSQAINDSTFWPIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLI9</accession>
    <name>A0ABY7DLI9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_029633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ96943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="59" mass="7062" checksum="E0FA24779B142BC8" modified="2025-10-08" version="1">MDSNLHEDRQTDTYTVADIYTVNDTETDRYTITDTETDRYTITDTEIDWYTIADTEIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DP21</accession>
    <name>A0ABY7DP21_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="101" mass="11815" checksum="B7DD8F5E26C63FF1" modified="2025-10-08" version="1" fragment="single">MFDSPWLCDFGAQMNQCLKDYRVNVKTEHVYHNSYDIPDDDLCTVFQKLRTCLFVEPSGDCQQNHSNFLNNIFRQRFSPSQCITLEQTTTKISKAHSHSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRL3</accession>
    <name>A0ABY7DRL3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="191" mass="21896" checksum="78FE331ED06F9F54" modified="2025-10-08" version="1" fragment="single">MLCYSKRNVRHHIQFVTTNGSSPHTVRFHKQFIITYSSSPHTIRHHTQFTITNISSSTHTVRHHIQFVTTYSSSPHTGHHHIHSSPHTIRHHTQFTITNISSPHTVVSTYNSPPHTGRHHITTSYRSSPHTGRLHIQFATAHRSSPRNQIIQVVTTYRSSTHTFVTTYSSSPQTVRHRKQFASTYSSSSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRV6</accession>
    <name>A0ABY7DRV6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="90" mass="10355" checksum="EACACF8FF49F90DE" modified="2025-10-08" version="1" fragment="single">FIERRHPQTTSTTERSPLEVDRPPKHRQDEVIYVNNNRKNPVYSTPYWNMNTPYNRLGNADAARGLSVATANRMTPLVTLLSLTVFNALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTD7</accession>
    <name>A0ABY7DTD7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FEM1B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24184:SF11">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24184">
        <property type="entry name" value="SI:CH211-189E2.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="374"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="407"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="440"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="473"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="761"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="905" mass="100266" checksum="2841E10C580C92CA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTG6</accession>
    <name>A0ABY7DTG6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR01033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="451" mass="50971" checksum="3F63F55123F532DE" modified="2025-10-08" version="1">MSGRPEASQLQAVFKELAGENGRVTSERLREFVQDLGLDFTQEEIREMTKEDMKREITNMSRELTQLRLNAPSRSSMVIAGRESPRKVPSRRAASRGASETYAAGRRSVMDSTVMEEHPDNTVTNQTASVSLPIRHPTENLSVPPSRQATAHYNVQPNRQTTEHRIELLKPDNQNDATIDTSDSISTPCAALVNKMSSHQGRPDGNTGDRHSVDIRDVKPAKVENVAPAPVVDQKIDSNSNTPGHDQLNTNECHNNTEIAVFVKPSQHESYDNVGGSCGIHIAEHRTDISNHERGSHDEQYGGQLNLPIDDHQTNNSINKEKGKYTVEIIQSTSRTISKGDGKRHKKKMKEPKVNDHNAKSLPAIRHKRPVQKTKRSRPPRLEEETPPGFRSGMGNEFRLSQLRIRQRVLYLMWRTVYDDVMTRARYANPDKKTVLKNERLNNNNTFNHHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTT0</accession>
    <name>A0ABY7DTT0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ING4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_007673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="121"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="574"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR01115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="632" mass="71469" checksum="B3B2092492E3896B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVH5</accession>
    <name>A0ABY7DVH5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR01074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="158" mass="17189" checksum="D03B9BB63BCC9AB6" modified="2025-10-08" version="1">MCVIGGRMTLCVIGGRMTLCAVGGRMKLCGGRMTLCAEGGRMTLCVVGGRMTLCVVGGRMTLCGGRKILCVIGGRMILCAVGGRMRLCGRRSYDTYAVGGRMTLCVVGGRMTLCGRRSYDILWKEVYALVCGRRSYDTVCAVRSYETVCGWRSYDNVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWQ9</accession>
    <name>A0ABY7DWQ9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_008716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR02158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="152" mass="17145" checksum="B5626875FE5BAD53" modified="2025-10-08" version="1">MPLPKKPDGYMGRTKDIVRLQKFCDEDLKVPSIVRFFGKGGMTAEWLDLKLLHALRAFQPHLVVLILSGNDVLAISSPRRIAGDVLRLRNAILDDGYSIVTCYGQKSTFVFLSFAKISEFTSIMKPPYHGVFADFRVTSVFSSSYRNIIINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXF1</accession>
    <name>A0ABY7DXF1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_008247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16496" checksum="42BF172AE5A0866A" modified="2025-10-08" version="1">MGKTMSYFEASRTKVLSLMFVDAIATPTYNKSSARASILISPQRLISGLNLRPLRCVSGCEDGGPVPEGRAGTGGRTSLTPHTMMKHLEHHNNLTNAQHGFCKQRSFETQLTIEDLAKEQTNAFDKVRHLRLLRKFDYYSIWGTSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0B5</accession>
    <name>A0ABY7E0B5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">INT2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_009197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Integrator subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026236">
        <property type="entry name" value="Int2_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029321">
        <property type="entry name" value="INTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14750">
        <property type="entry name" value="INTS2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02105">
        <property type="entry name" value="INTSUBUNIT2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1017"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1017"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR02639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1074" mass="120170" checksum="80E1D277BD7A11A6" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0G1</accession>
    <name>A0ABY7E0G1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative 2'-deoxynucleoside 5'-phosphate N-hydrolase 1</fullName>
            <ecNumber evidence="1">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine 2'-deoxyribonucleoside 5'-phosphate + H2O = a purine nucleobase + 2-deoxy-D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:51132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="ChEBI" id="CHEBI:142198"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O = a pyrimidine nucleobase + 2-deoxy-D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:57852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:26432"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="ChEBI" id="CHEBI:142209"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer and homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="1"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03036">
        <property type="entry name" value="Nuc_phosphate_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051239">
        <property type="entry name" value="2'-dNMP_N-hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028607">
        <property type="entry name" value="DNPH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15364">
        <property type="entry name" value="2'-DEOXYNUCLEOSIDE 5'-PHOSPHATE N-HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15364:SF0">
        <property type="entry name" value="2'-DEOXYNUCLEOSIDE 5'-PHOSPHATE N-HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52309">
        <property type="entry name" value="N-(deoxy)ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="4"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="12721" checksum="7EB8934CA9663019" modified="2025-10-08" version="1">MKIYFCGSIRAGRQDADLYLRLITQLKTYGEVLTEHVGAKGLENVVVAEVTQPSLGVGYEIGRAIDMGKRILCLFRPAPDKRLSAMIAGADNGSSFIVKNYQEEQAAQIFSDFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0Q9</accession>
    <name>A0ABY7E0Q9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_008981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR02423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="14994" checksum="114B58F03E6806EC" modified="2025-10-08" version="1">MISASTTMVGCAVSDCHGYYLYMCLYAPILKPADINTPYNESNRTCGDCPANCNRTANLCNSANMYSSGDELLPWEKGLPNCTSTTSAGITMTFQSTTTRTNPSQSPPPAGTTDFLNNSACGVMQNSALSMVFLALVFALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E110</accession>
    <name>A0ABY7E110_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NCBP3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="241" mass="26544" checksum="9C5423307552FB13" modified="2025-10-08" version="1">MPSYSKLKLLPSSSTRHQPGPSPDGQSGPVVIPPLSPPGRPGSDGPTPPASWCQLRSIVCLLAVGRDREGGEGGVELACLSAPRPYRDSQIDIDDTESDKRILIPANAETSPPSSPFQQHAVDKKDDVQFNVYLNKLDPPQTEKPTIRPTRVYENKSGDFVTGIDFRVESSVERMQERAKRFGIDFIPEPAVDLETLYDSLGLKPDDVKLKDERGMRLDAIHIRGVTEMNTKDATLSGWIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1B3</accession>
    <name>A0ABY7E1B3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U5 small nuclear ribonucleoprotein TSSC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_008854</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus. Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing. Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TSSC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029338">
        <property type="entry name" value="TSSC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13445">
        <property type="entry name" value="TUMOR SUPPRESSING SUBTRANSFERABLE CANDIDATE 4 TSSC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13445:SF3">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN TSSC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15264">
        <property type="entry name" value="TSSC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="47"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="192"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="270"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR02296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="307" mass="34970" checksum="2FF814B9FFEF1ECA" modified="2025-10-08" version="1">MTMKTEEEKHENDADDVGFKFGNSGLNQRCKDVFANLDALEARHKAFETKRAHDDWRRDEQLLTQQAIDDEPSGSEKPHSRRPVSDYHSRPRNTSADNRRPDREFRVPMPPRGRGRGQWRGRGRGVPDYKVHPERWTTYSLEDVDTSDASNKQAAFAFLNERKKLRETEQKETAVDLEENACSAGKITFTRRNKRETKAGNVAGQSVPREKQEGTVGRFEEGEEEEEGKSDDSEMKNPLKRQADGDLSECSASSRIKLDINDVTCGKSEEVGAECDSVQKPQFKSRGKAKKAFRSRQRTDDDDDNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E418</accession>
    <name>A0ABY7E418_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NRF6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_009697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045465662" evidence="2">
        <location>
            <begin position="32"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="655"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="690"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="728"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="92"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR03139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="760" mass="84730" checksum="0CDEDD5568930657" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E456</accession>
    <name>A0ABY7E456_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Immunoglobulin-like beta-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_019974</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Immunoglobulin-like beta-sandwich" evidence="6">
        <location>
            <begin position="315"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR04605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="558" mass="63625" checksum="93A60AB86F2A27BE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7P4</accession>
    <name>A0ABY7E7P4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_021382</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF14">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="8"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR06013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="241" mass="26810" checksum="733A27387A5A6EC9" modified="2025-10-08" version="1">MMSNDDSPPDSPRGFKVIPNTITSSSVVLTWIPGFNNGHLQTFHISYRPSKPFADWLEMNVTYTGETEMNVTLDNLEPGESYIVELYALNLEGASVKRNITFSTLTHTPSEISHLKTQTSTIAGGVTAGIVLILGISVVIFVFRRKYSVSCAFKLNPKEDKRSNFYPKLDHNNCLGKSKTVSKIDHIHLQIKLDIGNDRSKASHVYTSLDDSKSNVNYENVKPDDPVYNNTSLTNPAQTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E841</accession>
    <name>A0ABY7E841_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MLRP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_020110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAM" evidence="3">
        <location>
            <begin position="50"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="676"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR04741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="807" mass="90286" checksum="68CB960914C2259F" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8W9</accession>
    <name>A0ABY7E8W9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NFKI1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_020771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="548"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="618"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="451"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR05402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="724" mass="81041" checksum="925CC367267BF599" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EA16</accession>
    <name>A0ABY7EA16_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34839">
        <property type="entry name" value="CS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34839:SF1">
        <property type="entry name" value="MYOSIN-9-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="754" mass="74473" checksum="C9574783FD7D3250" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EB15</accession>
    <name>A0ABY7EB15_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TF2LX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_021366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="1028"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="1030"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="378"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1018"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR05997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1098" mass="119192" checksum="F00C03488080725A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBE2</accession>
    <name>A0ABY7EBE2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="248" mass="27889" checksum="2F29F5E023306D88" modified="2025-10-08" version="1">MAGQFVDEYSFKRSNQVVTLGVKTSVKITIDPQLLFQRLTAIADWYYEDVSGLFKYELSSVLSSLFDNTGLPRLAQKSQLADAMLKLGDCTIDLAENNIDKRKHFMVDHCCTEFLGQKNMTFGSIFDLYLNYITQRFSEATVVFDGYLEGPSIKDTTHLRRCNKTIGNQVKFGPDTPFKSKKDSCLSNSENKQTFIKHLGSHLVNHGITVRHATVDADLLIVETAIEHAQQGITYTIGEDTDLLVLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECY8</accession>
    <name>A0ABY7ECY8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CADM2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_021628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="113"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR06259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="201" mass="21318" checksum="6032E3FE70E5ADCF" modified="2025-10-08" version="1" fragment="single">GITTVSVVFPAGSSVSVIENTTRQFRCETSAGNPQATMEWYKDNGTPDRTDDTLIISGTETDTRASGTVIVTIGKLTLTAHRNDQEVRVYCRANNGGDWQYSSSVVLDVQYEPSTPTVTSHIRVISGRSMTLTCSSTGNPSPTYTWTYPGGGPHSGPTLTLASVLQTHTGGVTCTSINTLSPTGGKAVDKIQQTTISLQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EH11</accession>
    <name>A0ABY7EH11_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_019108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR09150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="36475" checksum="ADA23605200EAE38" modified="2025-10-08" version="1">MHLSKGQSQNMPVSGHTQVSELSSSSVPLLQGFSGSPGVTPHQEARPHPPSILQALSYQQRAQGLGGGSGPGGAPPDRAFGSGLPGLDPNLTAGVADFCRCYACGGGFHNWQPGRCSSTGKPVVEESNYPVQEKCDNNCENDGNIIGKHFPCLHLFCRRCRADPLLTSRCKVCNDEVKDYHALDLTPPMLLNGIESVKKCPFCRENDFRVCNWPCGHCLCGRCANNNFVCKICEKTVRFQYMVDANSFHGNGEQFGDKFNLERNSDMFDRQTGRMKCSQCQKFAVRIVYRNCGHCVCTGCSVDKNGRFCGICKSPVVQLWPKEICLNPMSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKY7</accession>
    <name>A0ABY7EKY7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">XIAP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_017814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="684"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR07856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="755" mass="86744" checksum="2D3447DDF58612F4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EL43</accession>
    <name>A0ABY7EL43_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_034763</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR09687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="86" mass="10045" checksum="BA8F53954AE6DF56" modified="2025-10-08" version="1">MSDVFDLVKTILGEVTLLYINLLLTWIDSEVVTIISTYILCQVLIYFTYVTSFLSVWFIVGFTFERYIAICFPLKRTSLCSVKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELN5</accession>
    <name>A0ABY7ELN5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">LRP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_035196</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF15">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EGF-like calcium-binding" evidence="11">
        <location>
            <begin position="102"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR10120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="147" mass="16210" checksum="D9CE1A6BB7B0137B" modified="2025-10-08" version="1">MVNRLDIVFVHTLSEDESNCTVAPCDEGFFTCHSGECVPDKVTCDHVLDCEDGSDENPECNYKDCTGAQFTCGNKKCIPKHWVCDKEDDCPDSSDEIPSLCDINECVDVAGTCSQGCVNTIGSYHCKCNPEYAKREDGRSCKKRDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELN6</accession>
    <name>A0ABY7ELN6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CO8A2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_034624</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF116">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045858545" evidence="4">
        <location>
            <begin position="20"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="21"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR09548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="159" mass="17693" checksum="F9792414F2069848" modified="2025-10-08" version="1">MSTLTAISCVLFISTQVLGAAIDRSVSFSAGLTSTQYMMDGDTVVYDQVFINDYNGYNPNTGIFTCPIAGVYIFHFHGYSQNKDTVMWLDLKHNDQKVVGVSGYNSHTVGSNTVMLKLRKQDIIQVTSRDKIQFALFGLPTQVYSTFTGYLVHEDPNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMQ1</accession>
    <name>A0ABY7EMQ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_035571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR10495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="269" mass="30855" checksum="E47001E0A509DCDF" modified="2025-10-08" version="1">MELEKEMSEKRKELKEVENERKEARTQMVRAAMSIGETDGKKFLSETMRPTALTGNVGAVVGVIESGLNLANDIFQFVKKGSQFAAMDKAQAKIEKDNEQQFKQLQEMKREMQEKREQKLQQIHKIKTLTLQIEAGVGDMENLREAVLHLGKVQRLLGEISAFWETMLGVVKFLQKNDEGNDLHILTMKYKPTDATKDIEESKQYWTMFGSICHGYARESTKEIGPLYSFLERPLDELSPGERMEKTKQLIQSIEEDIDKTYPANDSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENG1</accession>
    <name>A0ABY7ENG1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIGT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="555" mass="63319" checksum="7E6743D878D1050C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENL3</accession>
    <name>A0ABY7ENL3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPSD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_035487</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="25"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR10411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="231" mass="26334" checksum="712056DA86809663" modified="2025-10-08" version="1">MDISSNVYYVIGTIFSILFILALLENVAVLRVYHSCGKLHIQTNMWIVAVIYCDMLIVLSAFPLLIISSFSKGFMFGYYGCQWDGFIVTTLGTTSIFLLTGLSIHRYLIMTSIFKPNTIGRFRIMMAIGLCFSFGLFWGTMPLVAWGSFELEGIGISCAPDWKSRTLSNLSYTIAMYLFVLFIPVAIILICYISILLKIWREKKMRSAWIQKRSVMRDVKVTMSVAFVIYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERH2</accession>
    <name>A0ABY7ERH2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SNF2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16780" checksum="55933EDE2835AC67" modified="2025-10-08" version="1" fragment="single">MANVQVKDIRKDKRKQNYDSCKVALDETGEALLPFTEDKLKDLHQQISLQVGNQLVCYQQCSCLQEYSPLLPTSPLLVDYFKQHGPLVGRGWLFQLLDEQLNNTKKNGILLEADMGYGKSAIAAHITRAKDGDQGMEMRKRLIAFHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETL3</accession>
    <name>A0ABY7ETL3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22653" checksum="CF07286CE7C55686" modified="2025-10-08" version="1">MTPQEKGAGSECNPSEDTCTQFSRCVFKLGENRYTCTCEDDFTVEGTACKSNAMFLLPPPLPAVGEYLANPDFNSHWTEIAAGFRPDKDIQEGSCDPVSSPAVYIYDDTHINVSVSTYKQLEIAPVKKTDSFYEVSHGLGEYPGLVIMRALLETNGRTFRADGVGSSMNVFYRVDRFNNAYLVYGFNDENFRVWVDASPSGGSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUX9</accession>
    <name>A0ABY7EUX9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CNGA3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_003867</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF13">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="2"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR13762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="255" mass="30101" checksum="9C19BC3D24BACA1D" modified="2025-10-08" version="1" fragment="single">MKQYMNTWKFIIDVISILPMGYFYSFISLFSNVIFLDMESFIPGKMKILLVRAPRLLKYSTLVRFFDLTDSRTQNPNLLRTFKLSLNLWMVIHWIGCVYYLVSEFEGLGTNEWVYPNETEYDVFSRKYIRVTYWSLMTLTTIGERPPPETDLEFVFTGVTFLIGVFVFAAVVGNVGDVISNMNAARTEFQSRMDQIKSYLQHRHVNERLQNRVKRWADYTWNRTQSIDEPSLLQLLPNRLRTEIAISVHLETLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVW4</accession>
    <name>A0ABY7EVW4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8497" checksum="CCAB1AF9EEC357A0" modified="2025-10-08" version="1" fragment="single">MEILGLLDIPDRLLVPVGLIMAICLYSWYKQSYFRRIGLPTKPTTLIVGDLPLQYKKGFGYIDVESIQKYGKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EW59</accession>
    <name>A0ABY7EW59_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UN93A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF13">
        <property type="entry name" value="PROTEIN UNC-93 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="259" mass="28461" checksum="E411355469F72413" modified="2025-10-08" version="1" fragment="single">QIWGNLVASIVFRKESGNLTADFEVCGAQFCPFDQHKSGAIERPPEHKIFTYTGFCVGMSSLGAIVIALFLTNTNTESDNRDGACKNIRKVGALIVKSRDLKLLIVPAMTSGVLLSFFAADFTAAFVSCPFGVENVGVAVITYGVVLTVFSFINGRLAKVTGQYIIFLIVLVSVHFREDVTVALSSTKAMSSVGWAASFAYSNWLCMEYKIYIVMVLYTLSFVSISTLQLRHRKSDKLYRTCCVTSTSEQTEECIKVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWG5</accession>
    <name>A0ABY7EWG5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conodipine-M alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038875">
        <property type="entry name" value="PLA2_conodipine-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37687">
        <property type="entry name" value="AGAP006772-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37687:SF1">
        <property type="entry name" value="AGAP006772-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047037499" description="Conodipine-M alpha chain" evidence="1">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15218" checksum="2FC4DC92D780D85E" modified="2025-10-08" version="1">MSSGFILLFILAAIGPVAAGNCNTAPDVDGCSVKVNRWDLPPFFWDIFEPGCNKHDICYSCGAYYGVSRRLCDDHLYANNKKLCSTNTKVRHLSWCLQFAREYYLVWINFKHSYYKQTSPGWCSQSYVADCIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F018</accession>
    <name>A0ABY7F018_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_005633</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="14">
        <location>
            <begin position="236"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR15528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="509" mass="57544" checksum="9A47501ECC9B63E5" modified="2025-10-08" version="1" fragment="single">EITGYTRNTIRTGVIWFFIVITVGLLRLFFYWLPHLMIRAMYSECSLDLAQVVILKDEYGQWFVSNVMTIARDVTKVLGKGKSEGMVSHGSQALLADADQQQYSQNISRYFVTKKMKYIWNQESSMFSKVKGIEEDVTVNYFHDTSCLSFTDVSRRRMLYGFNSVDIHVTPIIKLLFKEVLSPFYIFQLFSCSLWYADEYEYYASCIVFISVLSITATIYQTRKMQRALRNTVQSSTIVSVIRNGNESMDISSEDLVPGDVIEIPRNGCLMQCDAVLITGSCIVNESMLTGESVPVTKTPIPNPRLTHEDSRMMFRPKDHGRHILFCGTHVIQTRFYGGHKVKAVVFRTGFSTAKGELVRSILYPKPVDFRFNRDTYKFVGILAGVNRGDAAGDIALRALDLITIAVPPALPAALTVGIVFAQSRLKTARIYCISPRSINVCGGINTVCFDKTGTLTEDGLDMHSVVPVNDEKNGYVPLIDDNRRCFKRGSTRTNYVRVNRLGRFDNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F167</accession>
    <name>A0ABY7F167_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="337" mass="39099" checksum="BE7FE0FEE4D1ACAD" modified="2025-10-08" version="1">MIILMAISQHTARSWKTVSISIYGCRIQPRNWFKWNVIWYKIEAVAVYDFASTAKCLTIHDWDIFKFNTFNDFFQFHVEQDTTGSFTPLFTAMSVLFCLFTRENVPASFCLSTPATLSSILCMFTLTVRTPVMSDQRENSTLLCPADRFQNNSTPSKLRVNSMGNCRDRDEVYRKWVAMKVKDRNLTGGRPSRKDLQLYSWEDKIASVIPRENKTQRSTCAEPDLLVRTDITLTQKMSKYSTKLCRTKSEIYLDRFWTENIEKSSVQSRSYELDKSACVDAPPVKRKMEVKRKAACTCSAELMNVERGILQESKQRNELLKELNFKMDAMLAMKQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1K4</accession>
    <name>A0ABY7F1K4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="266" mass="30054" checksum="ACCF7E529ECF9F4B" modified="2025-10-08" version="1">MAQTLREQNLRLERQNTRLQQVFTGLEHMCAALGKGTQERQSLNDSNEEAILEIKSVSSTGLLTGQDYVNVSVTYIAPINHAVSFTFIYKSNLIWNTAGHIRRGKKTHEYTSTVKLNEDDLDNISATLGEATSEQTFNVMPFEPAEFDLSKTGVVKNTTDSVVLSCKGRGRPRPKVVLQVYSENGQEMTSPEFQIEEQIKGHTSRKTVTLPSEEVKTVHTVLCTLLQEEGPHAYESKPKYKIEIFPGLIMEEDFDRFPNTTSLFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2N9</accession>
    <name>A0ABY7F2N9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045701195" evidence="1">
        <location>
            <begin position="31"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="276" mass="31307" checksum="72B803ED845BF9EA" modified="2025-10-08" version="1" fragment="single">MDSSRCKLSTLNAMILYIFILSLIHHGVHTQGVFKQIDSICIGECVAQKDWEFNGECPQTFCDRQCADQRLAIRVGYPIGTEYHCALNFDNRTEYRQTWAVVQNCSKGEQPYISFFKNNKQLPSNNGIIVCAKCNDSWYYKSEESTPSNTYHTCTLVKRNRCTPENHKLSCGIPWEDRTESDGFCRCDYEHGYALIGGDVPSCFYSKEECSIKTCPSGNELISNYSCVSVCPQGYYRDNTSRQCLPVIRKLNGTVQTQSESTHGPQVITTTGKYKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3D2</accession>
    <name>A0ABY7F3D2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="420" mass="46781" checksum="23FB7FDF824C34FA" modified="2025-10-08" version="1" fragment="single">IPCNQEDSSDVPKRDNSRAPQNDLLAIQKGQQEQIALMQEMMQNFAHLKSDVDRLRKQMQEPCDESEDESSSMPTPDVADQASCSQPVTAAGIFEDIAAALSLSEAKGSPVSGPLASLTDKIIDKTMEDKKNGMIWQISTPCQKTSRINPEIWRIIEAKTRSKDVKLQKIQQFTLRAMVPIMQVIDSLVAGRDCKESLNFDELVTKLVDAVALTAVGNADANACRRESIKRDLNEEYQAICSNTNPVTQMLFGDNITDQLKSITESNKIGFKADTLRERPYLPEIRLFFRTTTVSTALSSNTEGEGISSRRTAQGTVQRDSQTTCQTLTPTCNVAEVSYSNINCIKLAGRLKHFGTQWEQLTTDKSILETVYACTIEFIDTPNQTHVRETKLNSKETIVLDREIKGLLHKGVIETTEHCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3Y6</accession>
    <name>A0ABY7F3Y6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="497" mass="58710" checksum="4C027848F987C6E7" modified="2025-10-08" version="1" fragment="single">MSPVVNKLRKEFNEELNQLKSDMKSLPVNNAVPKESDQKKTTGLVLKNLPERRDENIVNSVNTFIKDGLKLDIKIKDAERKRANQSSECGIVVVSCNTKEDKYEIMKCKATLKQNATYKNIYIEHDLTPEERNSIANLKTIAKVIGNDKLYVKGNRLVQRTHNEESRDAHEWQEVRHRRKTSPHQVRTRSGRSDHRRRDETFTRRHDTDRTSYRHEHQSSRDRHETRHRDHARDTSRRHQGYHDGEDRRNYTHVKQSKIIHDRQNIPEVFMNNHDMYELLKEKINLLEADRDRQEHIDNSYTEFLDILNSQMKTHLNPREINLNVNNTKNKRVNKPWWNEDLSVEWKGVCVSEKLWLNCKIRSQKNLLKTILMNKRKLFDKNVKRRKRAHWHDEQSKLLKACENTNKSDFWKDIGKIGIGSERNKSIPIEVLLADGSVSTLPQDVLNKWKNSFEKLYNVPNINNEPVVIQNNLHENTLNTHSLNDGIHILEIDKAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F482</accession>
    <name>A0ABY7F482_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ARMC9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_005709</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040369">
        <property type="entry name" value="ARMC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048959">
        <property type="entry name" value="ARMC9_ARM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056327">
        <property type="entry name" value="ARMC9_CTLH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048957">
        <property type="entry name" value="ARMC9_LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14881">
        <property type="entry name" value="LISH DOMAIN-CONTAINING PROTEIN ARMC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14881:SF4">
        <property type="entry name" value="LISH DOMAIN-CONTAINING PROTEIN ARMC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21050">
        <property type="entry name" value="ARMC9_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21051">
        <property type="entry name" value="ARMC9_LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23138">
        <property type="entry name" value="CTLH_Armc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARMC9 CTLH-like" evidence="9">
        <location>
            <begin position="60"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="LisH" evidence="8">
        <location>
            <begin position="311"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="509"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR15604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="623" mass="69925" checksum="DA23DBDB8A42ECCD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4T4</accession>
    <name>A0ABY7F4T4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4430 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051588">
        <property type="entry name" value="Cobalamin_Transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559:SF18">
        <property type="entry name" value="TRANSCOBALAMIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559">
        <property type="entry name" value="TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR17195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="43971" checksum="B4FF6A4CBA6B7F06" modified="2025-10-08" version="1">MHEISSLVATQANKASGQFRYAVRNGVYAPTFNYEQDMDLVGNNTLVYYMNKACDIYPDTFTNYSATYFPSFGYFIDAINGVAADWDADKSYWRILNFSQPLSVGDEIIFNLTVYEEQQSTEHDAPTEAPTNMSSAPTYISSGATLTRSSASVITTTSTPATTTTTTSVTGPKFRYTVLNMMVKPYFSHSVHLRIEDKQPLIYYMEKACDKYQKKFRKFTVSFLQSFSGYFVDAINDVFGNWYENETFWLILNETGPVALGVSSYIPTPGDDITFRFVHGNDYLPNHNKTSQPPNTCNCSCNVPIGGQPLTKQPSPVTPYLYFGSDRIHWSRTNDKFGIVECIVFRQLNAPMLETPGVDFLVDQRHLVMISEWIRQLNAPMLETPGVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8T9</accession>
    <name>A0ABY7F8T9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_031788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031">
        <property type="entry name" value="SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031:SF3">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR17194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="120" mass="14344" checksum="B9C33E9F65D2959E" modified="2025-10-08" version="1" fragment="single">MASNFCTLSLGQLKTELRRRNAKLTGRKKELIERLEAYDRNQNFNREEDLLPEFNMSLPKTSGYRDLKTELRRRNAKLTGRKKELIERLEAYDRNQNFNREEDLLPEFNMSLPKTSGYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCG1</accession>
    <name>A0ABY7FCG1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_000322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR18484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="227" mass="25825" checksum="A838D79A3E382D56" modified="2025-10-08" version="1">MANSFLQNVAVNHRVIFDCHIERLAEPLTYVCSRYIRSVLYGLTTSFIRPKSKDPKVQTDNLEDLKGTRKSCIEESDRQKGDRMKVYIKPTTEVFYGSQSLKVPSLQNVPNMSVEERQNIMFGTLGLNAELIDTVSADPCTTYLIGVLRFWWTNAEPKVTENHLIAAIIGLILLHAEVFVEVMKRNPDANLLQERITPKSGPDVTSGPPQPWRSLQLYVHVQRLQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFV9</accession>
    <name>A0ABY7FFV9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine and tyrosine-rich protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022640">
        <property type="entry name" value="CYYR1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10873">
        <property type="entry name" value="CYYR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18694" checksum="B6199E60059886F5" modified="2025-10-08" version="1">MNGRMEDVRKIHNIFLLSLVSAEYCNKYGWISSQYCVYGCCTDYGHSGYEKCCSSYNYDHGIAVGPIVGIVVGCVILIVIVISIIVCCVCCMRNSRRTQGQTITTGASGPYIMNQMTYGVQAGQTPYGQQPYPAQPPLHTEHMAPGTTLVNSQAMQGPPSYEKCANNTNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHS9</accession>
    <name>A0ABY7FHS9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FP1V2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="979"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1133" mass="136861" checksum="325AD5380C340507" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIC7</accession>
    <name>A0ABY7FIC7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FBX6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_000839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007397">
        <property type="entry name" value="F-box-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039752">
        <property type="entry name" value="F-box_only"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125:SF5">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125">
        <property type="entry name" value="F-BOX ONLY PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04300">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01198">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51114">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="211" mass="23200" checksum="125964BDAEDD1050" modified="2025-10-08" version="1">MGVSNSGFSGNNSGRIASNGDKSGRMMEWEVVGNGGDGWSVETEPIGSDPVSDFNNECKGSVGCWATSYRECAKYQVVDLMAAGCCKYVLDHVRPAIHVSEYSARRDCGAVYKMTVVLMPEKTEEFWTASTENTNTTYSFDDTLLAGSGDWFQAKYTFKDYPMGIRYVGFYHNGKDTKFWAGNFGAKMTLASVILDFKHVAGPAESRDIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJD7</accession>
    <name>A0ABY7FJD7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GBP3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_016299</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GB1/RHD3-type G" evidence="5">
        <location>
            <begin position="141"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR22325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="371" mass="42988" checksum="05746D15FE707698" modified="2025-10-08" version="1">MAEKEHTTDSAAYGDVKSRKSFFESVFSDKSGKLPTRTLQGKNKTSPQTEKGQSHLAGNQSSTVVAKKDRDQGKEELHDQRKDDKVEVEQRLTKTPENRKTRDWFPHNLEVFKKPMCLISTEGENILKVEEETLKQIEKIDLPCCVVVVAGLYRTGKSYLMNRLAEAHSGFALGDTIESKTKGIWVWCKMHPEKKQTVLILLDTEGLGDVKKGDQKHDNRLFTLAALLSSTLVYNMKGTFDQDAVLTTYTSFYQQLSDKEINIIQMDNKLSEDERKKQADNRERTMKSMVEEIKQDNKQLLERLDKVRHAQHKNIQKERKEKFEEENEELKRKSASFTEEERKRLAQLETEKIEIKNMNAWGRFKCLFTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FK44</accession>
    <name>A0ABY7FK44_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_015070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd15551">
        <property type="entry name" value="PHD_PYGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046289770" description="PHD-type domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR21096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="452" mass="51552" checksum="9AA5403B76B784BB" modified="2025-10-08" version="1" fragment="single">TLSHLAILLLSVSCDVELNPGPDFPCGSCGNEVLDSDHAVECDKCNTWFHITCQNLDTNWYSQLVENDLSFVWTCTLCECLNLSNSSSMSVSTNNSFNSLVDDNILTQNSLPTSSQQNNKSIPKQPIFVSKLKILGISVVNKKLDLQNLIYNENPDIVAGTESWLKKDHYTSYTALRKDRLKGKGGGVFLLVKNNLVVSEQPKLQTNCEIVWVKLEIKGCKPMYISSYYRSHESDLQSLLELEKSLDLVNKLKDFNFPKLTWDSEHMPHLKPGFSTTTVYDKFLDIINDQNMTQMVSENTRNDNILDLFLTTNLTFVDKVNIIPGISDHDIISTIVNARPNILKQKPRIVPLYRKANWDDFKQFMDTTKSDILQGSDSLSVEEIWLRFTDAIKKGITQFIPVKKIGCKRALPWITKEIKRLIHKRDKLYTKLKKNRTDSNISDKFKSLKATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLF4</accession>
    <name>A0ABY7FLF4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UN13D-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_016386</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the unc-13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052095">
        <property type="entry name" value="UNC-13_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999:SF4">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="110"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR22412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="874" mass="100231" checksum="2FD3E5F207592624" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMV6</accession>
    <name>A0ABY7FMV6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DMTA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_037217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DMRT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd14370">
        <property type="entry name" value="CUE_DMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005173">
        <property type="entry name" value="DMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF116">
        <property type="entry name" value="DOUBLESEX-MAB RELATED 99B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03474">
        <property type="entry name" value="DMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="8">
        <location>
            <begin position="38"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="6">
        <location>
            <begin position="38"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR23548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="382" mass="42023" checksum="44616B70FC7FBA0E" modified="2025-10-08" version="1">MSSSDEERAGSESGSTTASADTVLLRSASDRYPRTPKCARCRNHGVVSALKGHKRYCRWRDCMCAKCTLIAERQRVMAAQVALRRQQAQEENEAREMGVLYGPTGLLQINPECSNIYPNAATSVEPNGKTKSEDEADIESPPMAKRQKTDHKDDGGRLSVSSDDSRSVSPSYTDERRFHGSTPPHSSKLPYEDIASLYDRNGRISEYWLLNFAQAPHGTKKTQQPLDILCRIFPHKKRTILEMILQGCGGDTVQAIEQVMATQRQEEKSNGGLIYPGVSHAPLGNHLQNPVFKSAFSPIPSLTAASTLNSMRYAWGNAAGRGLAMAMPYSHLFPGLSMGSSFAYNPLGTSSDKISPYSMYPFWTGKPFPTKEVEKTSGCISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPG6</accession>
    <name>A0ABY7FPG6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZN367-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_036888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF26">
        <property type="entry name" value="ZINC FINGER PROTEIN 367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR23219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="179" mass="20140" checksum="EE3A98FBC33E626D" modified="2025-10-08" version="1" fragment="single">MYPWNWADGHSRVAFSPRSSSTSSQEADSLEGEPTGVIRDHNKRGRPRAEKISSLILEGALSTNSIRCRICSRVFPREKSLQAHMRTHTGERPYLCDFPGCCKSFCQSGQLKTHQRLHTGEKPFACSIEGCDSQFTHANRHCTDHPYASLRRVSTQEQLKSRMGAIKASTNQSVSEWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPI5</accession>
    <name>A0ABY7FPI5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EXD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_037814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052144">
        <property type="entry name" value="piRNA_biogenesis_EXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628:SF1">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="27"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR24145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="351" mass="41241" checksum="21E6B0630FE865D4" modified="2025-10-08" version="1">MEGRVTKELILPISRILHTSEGGDADYELVDQKRQWPSCLIAIRHAVSKGQTLALDCEGDSLSRKGNIQLLSLDTEEKTFILDIQKLKAFPFERGLREILEDKNLIKLMFDCREDADALFHQFHVTLDGVLDIQLLEENSINRKRGDHNFSAISLNSLLGCMKKYFQCEESVKQKEEGMRLEKEWTNRPLTAKQISYAQIDVYLLDWLFDNFKPSDEELARLKIASRIYLNLKRFIPCRKYNEYENNTYLPVDVIPDKGSSSFPKGYVSCTECYRQFPEDEFSIRQVKKKNQMCRTCKKVKNDKSVQLTEYQFEYFDNDDVTESAERENEIKQYQEQCDEEERYFSEVLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPM5</accession>
    <name>A0ABY7FPM5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">STR6L-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_037837</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026612">
        <property type="entry name" value="STRA6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444:SF15">
        <property type="entry name" value="RECEPTOR FOR RETINOL UPTAKE STRA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14752">
        <property type="entry name" value="RBP_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR24168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="460" mass="52953" checksum="4D29A579FD3D59BC" modified="2025-10-08" version="1">MSLLNSPKSFPMQTPETTTPVDKEYEHCKQEVFGNNILKSYSHWFLIPSLFRLVAFARCSAKFDAPDSVGLTGRASIEGELPIVLFSLIVVIKFVWKLAKCIKQKKYSRSRSEEAGKKLCKKTDLLYVKALFNPRKYTETEEALRRDMLCLYKGDRSFIPAVLRNCPPNIYMAQGMRFIGNSIVGSFWGSIFVYVVVCVPVALMFLTFRVLDDSDKLHLLWPRFEWLIYPVCTVLIFKAQSILVAKFFMQPKLEESHKYKPLAVNNRTVYDVFSFFMLFLNASIGLVQYVKRILFSAVLGVFLIPRMDRSLYMRGDAMETTRNRATPTTENPLYADVRPEHNDKKLSIAKRRWLLAFTLVRNPELKQWRVHGKPKIKIDNSVYVDVSDIFVEDAENGSGISDNMVMDTWGCVCRCCKNYKLTIPPNIATNIMAECLHLNPVQLNCVRLYPICLSIIIYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPS0</accession>
    <name>A0ABY7FPS0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">KCNAB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_036385</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003973">
        <property type="entry name" value="K_chnl_volt-dep_Kv2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01495">
        <property type="entry name" value="SHABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047470003" evidence="14">
        <location>
            <begin position="19"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="3"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="515"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR22716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="634" mass="70244" checksum="A1015497A9CD5A63" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQ31</accession>
    <name>A0ABY7FQ31_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_036811</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR23142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="144" mass="17145" checksum="AB900E8840D71AE3" modified="2025-10-08" version="1">MGIAKSKFNEYWPDVNENIPSRLEIDIKGPTFDPMLGFPNGRKERVAPLTHEVMVDANIPLKYRDYCSDKYLDWLQCMREESFGRKLFGGVCHPAKHSVEECVYKDTVIRWKEYEREKRLRERRKRRIEKGLEPDPDSTNTEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSK5</accession>
    <name>A0ABY7FSK5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8979" checksum="442E0150FEBD93C1" modified="2025-10-08" version="1" fragment="single">YSGIKKSLEQATSNEEKHIILCGNFNCSDIDWQSLTRSKKSYQSLQLTSTSLMSILNQQGKQHPRYGLHLKHIPYKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSN5</accession>
    <name>A0ABY7FSN5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_038271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="109" mass="12261" checksum="18632D445C0E69AD" modified="2025-10-08" version="1">MCRWGCTTTNTTYMCKWCGTRYCRECLRGDFLGLMPEPTHCRICNQKRCQGNRIEYVPRSKDEVDPKTQKSKSAAGMRTRSAAASAKSSRSVKSARGKSGKKSGKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTH0</accession>
    <name>A0ABY7FTH0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YQA3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964">
        <property type="entry name" value="ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964:SF113">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="45"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="129" mass="14350" checksum="49978DBD653C224E" modified="2025-10-08" version="1">MAEQQVESQDHHRKIAIAIDESEHSQHALQCPAVVDQLLKELTNKVAALEKKYKALVQEKKLTGKFRTGQGKPGEVICRISEEEKCVLVVTGTRGLGTVRRTFLGSVSDYIIHHSHVPVLVARSKAPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FU44</accession>
    <name>A0ABY7FU44_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_038338</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd17946">
        <property type="entry name" value="DEADc_DDX24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="191"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="517"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="229"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="724"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="250"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="762"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="782"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR24669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="804" mass="92199" checksum="DE5E6D1ED7D9BEF0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FW83</accession>
    <name>A0ABY7FW83_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative hydroxypyruvate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_037110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate</text>
            <dbReference type="Rhea" id="RHEA:11952"/>
            <dbReference type="ChEBI" id="CHEBI:17180"/>
            <dbReference type="ChEBI" id="CHEBI:57978"/>
            <dbReference type="EC" id="5.3.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the hyi family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.22" evidence="4"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026040">
        <property type="entry name" value="HyI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050417">
        <property type="entry name" value="Sugar_Epim/Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43489:SF6">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43489">
        <property type="entry name" value="ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006241">
        <property type="entry name" value="HyI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="7">
        <location>
            <begin position="23"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="7">
        <location>
            <begin position="180"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR23441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="242" mass="27803" checksum="FE487F864F09430C" modified="2025-10-08" version="1">MPLKFAANISMLFQEIPSMVGRFKAAKDAGFKYVECTFPYAEGSEELGEACKEAGLQHVLINNWPGKMEKGELGMAALPDRVQDFRMQLEMAIEYANCLNCKRMHIMAGRTSRYKHEEMEETYLDNLRFAAERLQKEGIMCLIEPLNSRITAPNYFLSNFHTGVEYIKKVNHPNLKLQFVSHIQIAQVPDRGEPDLNGEVNYKYIFQLLEDIGYEGYIGCEYKPRATTQEGLKWIEELGIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWP5</accession>
    <name>A0ABY7FWP5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="37"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="128" mass="13453" checksum="36057F1AC4C69159" modified="2025-10-08" version="1">MSTQPHDSQACPEAKPLICMVTNEGKTTASSSCRANCTDKPTGPSIKDQYFKLVGTGVSPPPNVTTISHVTTGSPRLCGVECLKVSVCGSFLLNPGSSQCLLYAGNHSSTVVQGPIGVKYFVKYKNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FX67</accession>
    <name>A0ABY7FX67_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="449" mass="48413" checksum="9CEA2990D68E820C" modified="2025-10-08" version="1" fragment="single">MSGWVGNGGEGQDDPYPVETMAWKLKQRLQDTEPVCMGYNGQNRKCCDNVRMCFVELRSALDGVQLAAVGNQNMHVACRTVERKLGESRQCMTSWASQCHASVNADVILRPFDDALLDMNDQQAEFCSNLPPEPTTRLNTSPIVTTRSPVPETTPSKPPTPKSSAVPPTSKPTSVSTTSPNISETTSTSPPTSKPTLTTVSTSTLPKTSVSTPRRNSATTLKPTSTMKTSTAVKPNTNVTSATSGQTVKPIETTTKTEQQTNPPFISTSASMTTTTASGQSTSGTSGSPVTQARHGEKDSQDGIIAGSSVVGVVIIALLIIAGVCLWRRRKRRKAEAGSSTDSRKIMWRLFSRNRKSGNGGSDNNDTEIYAEIDDTFRVPSNRSQINVCYESTFGDNDVIIPSSHLKPKSQVSVVTVGNSAPVLDFIRKEDDMVTSFQTERLPNKQVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FY92</accession>
    <name>A0ABY7FY92_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_011843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="125" mass="14775" checksum="C022228AEFFF6656" modified="2025-10-08" version="1" fragment="single">MYCLKRFSYSPPVYRMMNLIAAIDQNNHLEREIQHNKDVSVRSTADLEDFNQHILMYCSKRFSYSPPVYCMITLISPVYPVKEKKTYPYLETLKKEILMCHLIDDVGMSGKDVMKKHNPRRISSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYQ7</accession>
    <name>A0ABY7FYQ7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_011763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046644084" evidence="3">
        <location>
            <begin position="22"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR26059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="306" mass="33075" checksum="7F76B36FD5C377C7" modified="2025-10-08" version="1">MLSVMTRSLALLLVVVATVYAAPPVRIDSKDECGSTNTVELDSDFRLVGRGVAAGANSTKDSMCTFSFTATDGAEGCMGLCYMFDHYATINDMKVELAVGPKVFKKGDAFPMEPVCMEDKALPVTLTQKTGYIYKKDEPNYKFVLSVYNKCGMKGSVINIDFDEAIQLVDGYHHGEKKEDRERSTFIAGILLGFGLSCIFLVVLAIGYCYTRNSPTGRGRSSSAMKNPDQPEVKPLLDPVKPPAEGATGKHSDDEEPKADVAPEIEPEDKEKKSDQPAGKAVETRENTTESSDTPATGDAAPADEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G015</accession>
    <name>A0ABY7G015_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="180" mass="20106" checksum="E0E8BE4381C7F64D" modified="2025-10-08" version="1">MSFNPTKCDVIRIAPCCRKIIDTKYSLHGHTLEVVDASKYLGVTITESLTWEKHIVNITCKANRTLGFLRRNLRECTPPVKKASYKAMVRPSLENAATVWDQHLQNHIKAIEQVQRRAARFTSSQTGTSKVVMREPGANTGYSRNQVLANSFPRTVSEWNLLPASTVSAPTMDAFSIGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4H7</accession>
    <name>A0ABY7G4H7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IgGFc-binding protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_002915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046958948" description="IgGFc-binding protein N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="585"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR29347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="72531" checksum="6E33458804FB9514" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G517</accession>
    <name>A0ABY7G517_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZN888-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_002833</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF416">
        <property type="entry name" value="FI01424P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR29265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="498" mass="57506" checksum="E8FFDC27E3E232CD" modified="2025-10-08" version="1">MIHTFIVSFRFTWICTKRRPYTSKVRGTKLFLKENLKQHIKIHTGEMSYMCEICSAAFSLKGDLQQHIRIHTGEKPYKCEICNAAFSQKVVLQQHLRIHTGEKPYKCEICDATFPHKGTLQEHLRIHTGEKPYKCEICDAAFSQKGALQQHLRIHTGEKPYKCEICDAAFSQKGALQQHLRIHTGEKPYKNIYEYTQERSHTSARYVMLLSLRKVHYSNIYEYTQERSHTSARYVMLLSLIKEHLRIHTGEKPYKCEICDAAFSRKGVLQQHIRIHTGEKPYKIHTGEKPYKCEICDTAFSWKCTLKRHRIIHTGVKTYTCGICDADFSLKSSLQQHKQIHTGVKPYKCGICNAAFSRKGGLQIHKRIHTGEKLYKCDICGAAFGRKGHLQIARIHTGEKPYKCGICDAAFSQKDALKNHSRKHTGETPYECDICNAAFSRQGAYKNSHQSDVVQVRDRGCCFPSDKQFTEELECTNTKDGNQRHIHMDIHKEKTIHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G653</accession>
    <name>A0ABY7G653_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="86" mass="10036" checksum="64DB2F544CF3DCEA" modified="2025-10-08" version="1" fragment="single">MNVMLQKLNEGKLMEIRKAVTDDIQVKLRQLRAKAEKLHSLRIKQDQAFNTNSRAMTSHEDSDKDLNVCNNNEPQKCDENQKLNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6C9</accession>
    <name>A0ABY7G6C9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26611" checksum="E82CE070F414C219" modified="2025-10-08" version="1">MELYLETKSATCATLVIRFKAQLSKRVQTTRNGNQFSLTNVKYKKNDQQLEKNVKNLNHFTTDCGNVTFVAGGVVHYNTGTLVGDTVSFTCDTDSSILQQKQCYSNNDPHMKTFDGITYENQNEDRFLLYKNQAFQQQVTFPSGTIVDLSLQEKFVNVAVFPSLADLNNTEGLCGRFDGDTVNDRNKRPGSVENDPALSWRLLEHEDLFGEKYILEHVNESMKRCSCNTEEPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6F5</accession>
    <name>A0ABY7G6F5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PA24A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_014628</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2 3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="5">
        <location>
            <begin position="1"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="665"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="665"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="703"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR28924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="735" mass="83860" checksum="F06728E0CD19939B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7A5</accession>
    <name>A0ABY7G7A5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GELS1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF130">
        <property type="entry name" value="SEVERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="190" mass="21845" checksum="4B4A47AAA6D0F529" modified="2025-10-08" version="1">MAQSAAETEPAWRIAGRKPGLQIWRIVTYKDQGSDILKYDVHFWIGKYSTQTVELDTYLDDRPIQHREVQGHESKLFKSYFKTIELLRGGADSGFRHVEAEAYQSRLLHFHGDKRHVEIAEGVFYGKLDENVDDIVDSEEENQNITKSDTIKKLFRTCLFWTRAKMSLFGSATGPQKMSGGTPWSMHTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7W1</accession>
    <name>A0ABY7G7W1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MESD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_003062</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MESD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019330">
        <property type="entry name" value="MESD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17600:SF2">
        <property type="entry name" value="LRP CHAPERONE MESD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17600">
        <property type="entry name" value="MESODERM DEVELOPMENT CANDIDATE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10185">
        <property type="entry name" value="Mesd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047430454" evidence="8">
        <location>
            <begin position="24"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="175"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR29494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="693" mass="81948" checksum="565A3FD30083FB8A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8Q4</accession>
    <name>A0ABY7G8Q4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RBGP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_032844</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="15"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR30302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="415" mass="47936" checksum="E103EB65A50172DB" modified="2025-10-08" version="1" fragment="single">GDEPLLSGSGVVSKEITDENLLEAWREVLKKWQQNLTQKPKQESSGEGVIQRDINRTFPAHDFFKESGGLGQESLFKIAKAYSVYDEEIGYCQGQSFLIAALLLHMPEEQAFCVLVKIMFDYGLRDFFRNDFGVLHLAFYQLERLLQMGLEAHMYASQWFLTLFTAKFPLFMVFHILDIFLSEGRNFAYHVALGLLKVSRKDLLALDFEGVLKYFRVALNCKIRGSKLKKYEKEYQAMKEQEMQQEDPLVRFERENKRLMDANIRLEQENDDMAHELVESKLNLSKKLDAVKSRLVRVPNHGVNDNQEETSRDRGRKTETGNRVLTDSVNPKVLNLESRVRELELELAQTKLALVEAECKSQDLTHQLTSAVTEIQASKNTWFSKFQNSIKDVSIMQKKDPSTKDLQRKDSTSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8R8</accession>
    <name>A0ABY7G8R8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_033347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="166"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR30805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="299" mass="34471" checksum="97A7ECAC2202246E" modified="2025-10-08" version="1">MVIMDMSMEESQCMQNTEEGSNDMKLLPNAFEPVKPLEIWPYFKKEECSQDVSNSTPMSENVFVPDPFLHCDVERHNCTDDKCGRLSWGSSFNEILFTVIARVAAYDQNMSWMLYKLLIIMTRLLSMILSIVSAQLLRRRSGEDLIFEIQLIRSGLESNPGPRDWIDDDLAYLSNYIGKGWRHLGRKLGLGPARLDHIEHDFQREGMRDQIFHMLLKVKAPPLEASLKDILETLDVIEAEFSITVEWSELSLRFKNEELKTENQELKEKLASLERDSGALKRCSEDGDAPTEVKKIKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8T6</accession>
    <name>A0ABY7G8T6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047509425" evidence="1">
        <location>
            <begin position="33"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="147" mass="16781" checksum="92302C9916B2F6F7" modified="2025-10-08" version="1">MMYDFQTIAQYTCLSCALASLCILCQVSYTVSEYSPYETYSSSDIRNLFSPQSGYDDVNKYDVNKEDEYLPVDKSVTFNNDFPQVTFPEARVSRKAIKLSRFIGKSANKSCDLMHSLNLDSHGENPSGMVSETIRQLVLLLWRKTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8W8</accession>
    <name>A0ABY7G8W8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="113" mass="12958" checksum="EA6B4E951A921C33" modified="2025-10-08" version="1">MQMESQFGVNEYQDLGISVQNVYDELEKTNGGKLDTKYSKTTHSDDILEQHMGEIRTDENDELDCNQYENDQPNLQMESHSGINEYEDLGMSVQTNYDDLEKTNGGKMDANYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBB5</accession>
    <name>A0ABY7GBB5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRJ1A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF17">
        <property type="entry name" value="SELENOPROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="272" mass="30077" checksum="35FE7C66BD5F0018" modified="2025-10-08" version="1">MSSKVDVRRVAAVVGALVADAAGQPIHWNYNLDRLDAILAETPEVAFIEPSINPFYTLPCGSQSGYGDQSFTILKSLVDNNGRCNSLYSISLNTDALNKAMYDCFGPDSAYENDTNAIYKDKSDITTKATKYPIHGPWRHFGIKEFLRNFQERKESTGSPTDEQIDCAVRIVPVVALYAGRPEMLSRAEVVVRQTQDNDMCVAVGLAAARILEYCILNGRTDGAVEATIEQLSDQDRECPQELDKAVAGFLREVVRRKSEPHIPVARSIKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBF9</accession>
    <name>A0ABY7GBF9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_033241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="508" mass="57990" checksum="AF612A6E493D459E" modified="2025-10-08" version="1">MSIINASVEQTDNYKVQANKMSTEVELQAVPSDTSQEERTFDQVEIEPTEENVTVEGADNPAYTDTETTEQTESDFTIPPMTFVDFMPRLIEEAASNVDSPIYSEFSSVMEQVNQWLKGNPDYQAMKLESFTKKLSEKENAPDLEQVMYHESSYGINKYVRGLRLWLAPRLDTSSPIQEIGYITTMPEPSEGEASDPDSMLSLFKVGMFNARAVMPTYCGYKEMMDKLNKFLKKKPLPGSVLSIENVKVKYDENSLGKCMDSESMSWADCGKDDRIYMFAIRIYYIIGKPTFEVVSYHDEAPVCQNNWETMSKLRYCPFTTVVQRGRAWLRNQKGIRVVNMQTVDVFCDRTSKGEARVHHDKTGYVEAAGKDAQFARVLRIFYIVDPKSSVCPYETVNLTSRLFIPTRRGDWGKNCETFSKTMQRVIKWLQLTKVPIFGVETVIHPFTPDSYGTGVRDDSSTVSLIAAQGKYFITTVRLYFPCEFEEPDPKLLPQPEEEEGWWACTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBR4</accession>
    <name>A0ABY7GBR4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="256" mass="28882" checksum="D7E9A1A3551A2A5A" modified="2025-10-08" version="1">MCSLQVYIPLLLDLTRVNHKYLSHDLRSARRNKIREGRDTQHTSYWTVHLEIWTFGSLRKTTTSQQRQRKKDLQKETMELDEIIALASTPGYRGFIVHKRTSHKRATLEIIKLTVGKGKSAYLESKLLRMFPGSGSGPVSRQCTHLEMSKTSANSKEKKGKGDPTQLYQLPDYNPDLWNTSAITRLKNSTYNYATNIQTNTFSKPGRGNGVINWGTTQHILDGCNADGLKERTDGELPSERENTGAIALAVWATDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GD07</accession>
    <name>A0ABY7GD07_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4CLL5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_034522</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="136"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR31980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="227" mass="25110" checksum="480603CDCD31D004" modified="2025-10-08" version="1">MAASLIKFPERHTYDVSSVCFVMSAAAPMGVGVEEHLRQLFNVPFISQSYGLTETGYNSGNTTDRHRLGSNGVPPIGTNLKIFDPETDEELPRNKTGEIRVKGDIGYLDSDGFLFIVDRLKELIKYKGLQVAPAYLEDIIVKHPGVADAAVIGIPDPDAGELPRAYVVRQTGSHITAKDIVQYVHDHVAPHMRLRGGVEFIPEVPRTPSGKIMRRHLKPKKQTTSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GE29</accession>
    <name>A0ABY7GE29_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LRP5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_034050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR31508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="211" mass="22896" checksum="C353D211B787BB97" modified="2025-10-08" version="1" fragment="single">CLKLQRVDMNGSENASTGVKELRRMGKRAYERAAEHRKALPFSGRCSESYVCRKLPTNRTCDVQCIPKSQRCDGSPQCPLQDDEETCPTKCQSGSFLCPSGKCAPICDGQAQCDGPGDNNDDERNCTCMTGQTRCPNGTCVTPCNETPECNNGDDEAIYRLLCFGDLCRLATNDAECTAYSDKVALCKGGQNGMCDPLTGLVRRSQGGDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GI46</accession>
    <name>A0ABY7GI46_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="143" mass="15636" checksum="A4B4974B4BF2BE89" modified="2025-10-08" version="1" fragment="single">MIAGCSVKAVYLTCLKGGMQMDTTCWEIVDIQLRDCCSPPTWHHIMEQKKATTEVTKSHELLWRDLLDNSRKACCVLHNICKERAIPIKGDDDSDDEDDNADDQLAQGVQLPPNGHDFHAGAAVTAAVVVSVVAATTSRTVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D813</accession>
    <name>A0ABY7D813_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PLDX1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_006288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031152">
        <property type="entry name" value="PLXDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13055:SF12">
        <property type="entry name" value="LD40707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13055">
        <property type="entry name" value="TUMOR ENDOTHELIAL MARKER 7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ93817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="516" mass="57836" checksum="25834A1CFDA13DF3" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D9N4</accession>
    <name>A0ABY7D9N4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="68" mass="7827" checksum="2604E3FE7F2C288C" modified="2025-10-08" version="1">MYDGRSLSSPAINRIGTRNIGMDTWTYSQNHDENFAPLTLNVIFMQPVANHQKPMHLPANWKRCPVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D9S7</accession>
    <name>A0ABY7D9S7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MAR_006509</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040622">
        <property type="entry name" value="EGF_integrin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057073">
        <property type="entry name" value="EGF_integrin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014836">
        <property type="entry name" value="Integrin_bsu_cyt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057243">
        <property type="entry name" value="Integrin_I-EGF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF60">
        <property type="entry name" value="INTEGRIN BETA-PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23105">
        <property type="entry name" value="EGF_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18372">
        <property type="entry name" value="I-EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08725">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01241">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00243">
        <property type="entry name" value="I_EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0401">Integrin</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit VWA" evidence="15">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit cytoplasmic" evidence="16">
        <location>
            <begin position="566"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAQ94038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="612" mass="67790" checksum="C21C4258822BD4FA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCJ8</accession>
    <name>A0ABY7DCJ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MATN2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_006546</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF87">
        <property type="entry name" value="COLLAGEN ALPHA-1(VI) CHAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="186"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="380"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ94075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="570" mass="62736" checksum="DD783C8698FB3824" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFJ8</accession>
    <name>A0ABY7DFJ8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF3">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="85"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ95209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="364" mass="41454" checksum="1F7548E4DA948FC7" modified="2025-10-08" version="1">MTSEKQLRLPSDDVKWEKNKSNAWPKLMYEDLVDYLIHAKAYDGKAMKSFRSLYGYNYVQNVGVTYIKAKISPSQPGVGRKDYNSWIAVSSENTVETGHCTCPAGNARSCSHISAFIYAITLAWANGVGKHVQTNSGLGVKEQRKYGHMTPFQIWCLTKTTENQNSCVWTDSRKLRLTSSKVNDLPKTKRANPNKFVTNQIYPRDDLLHVMDRNTNQLHEPGMKVFLVTSLTEPYIAASPDGIIDKRTIVEIKCPTRPLEDLISSGKYDVLLEDGQPKLSPKGKNGYYCQVQVAMFCTESTLCKFVVWTAEKQCVVDVPYCKDFIKGILPRIRDFYFKHLLVRLTDEFQASRLKISPEYKSLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGD4</accession>
    <name>A0ABY7DGD4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PTH1R-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_006541</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="11">
        <location>
            <begin position="46"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="12">
        <location>
            <begin position="118"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="12">
        <location>
            <begin position="201"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAQ94070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="317" mass="36358" checksum="878000A44F17B9C5" modified="2025-10-08" version="1">MDEFCAGLVSETVNKKNKTQEGMNVVYLTKEEQREVLFRQYQHCACRMYREPYNLSDYASRTCLPNGTWASHPGVAGSDLTGWTNYTACQTNQTADGRLENDDSSDVPNIFMENFQQLQLMYNIGYAISLSSLVVAFTIMIFFRKLHCSRNSIHLNLFASFILRAAISLIKDNFMVKGLGFPGDVVYNDTGGLVVFTDGPLNFISFINILRVLYTKLASNLCPDSNKHRHRRLARSTLFLVPTFGVYYIIFTIPIPTVNENVDFVMLFIEMFFNSFQGFFIALILCFINAERFGMLDNYYPESLVFAEISFIIHWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DH65</accession>
    <name>A0ABY7DH65_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_028735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="426"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ96045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="741" mass="82657" checksum="51D450065806EDF9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJQ4</accession>
    <name>A0ABY7DJQ4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KLH24-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_029856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF30">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="46"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ97166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="585" mass="66361" checksum="AEB09AE02913598F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLT3</accession>
    <name>A0ABY7DLT3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MEG10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_022990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26391">
        <property type="entry name" value="INACTIVE TYROSINE-PROTEIN KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26391:SF18">
        <property type="entry name" value="PROTEIN KINASE RECEPTOR TIE-1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ98617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="322" mass="35418" checksum="5A9BE172E0B1E597" modified="2025-10-08" version="1">MTLHATVVPDSTLCLACSATVGIESPWLQIDFGTKAMMRTLRIFGRDYDTPGQSSNLLVSISNTSHFVNQNFSTWEDFGLINASDPYNGVMWDLGVNRVLQYLVFRRPLPSVMAICEVAVFNTDCEKGFFGDKCASMCQCKDEQPCDSVTGKCATPGCFAGWKGDSCSTDSELSRYTTNANHHILDKTVAKHVIATYLDRATPSMDFVRMECVRRAGWVIAVIKNVTMVDLGKAAVIHAIATTAHRAITQMAYVPITYVKRDGRETVVVKNVPMVHLGKAAVIYAIATTAHRAITQMAYVPITYVKRDGRETAVVKVVLLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DN46</accession>
    <name>A0ABY7DN46_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DACH1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052417">
        <property type="entry name" value="Dachshund_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12577">
        <property type="entry name" value="DACHSHUND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12577:SF6">
        <property type="entry name" value="DACHSHUND, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="75" mass="8040" checksum="F410863C166C1E43" modified="2025-10-08" version="1">MADSAELMETLSHDDVGEATNEDQHSTTGMSNGALPGYSSIETLLLNIQGLLKVAGENARHQERQICKCLIPTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DR88</accession>
    <name>A0ABY7DR88_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_023484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045150808" description="C1q domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="3">
        <location>
            <begin position="60"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ99111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="216" mass="23681" checksum="E5E62A0BD149B967" modified="2025-10-08" version="1">MDLVKRCFALVVEVILCAPNFCLASKTCSANDVRTAVLLIRETQTVIREQKMDMKQQLNTLQEEIRKKGKEIDNVTLSDNEIIKFDIEETDTVNSYDTTNGMFTAHVDGFYFLAITIHSPGNIYVGAEIVVNGVVKGEAFADSEEIADTHSSSAMTIVQMSAGEKAYVRRGSDSQSGLWSHASRGLSTFSGWLLNKGVCLGGCNEVNSKCNSLCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DS73</accession>
    <name>A0ABY7DS73_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IgGFc-binding protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035234">
        <property type="entry name" value="IgGFc-bd_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46534:SF1">
        <property type="entry name" value="IGGFC-BINDING PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46534">
        <property type="entry name" value="IGGFC_BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17517">
        <property type="entry name" value="IgGFc_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IgGFc-binding protein N-terminal" evidence="1">
        <location>
            <begin position="89"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="401" mass="44098" checksum="3F460994D589989D" modified="2025-10-08" version="1">MDTTSGAKATPSSIVLRFTADSSTRVTVSIKGTNSSDQTKWGRNGEFTLPASTLIIDDGKHSNRAVIIHGDHDFSLLAVYQFPDFEIPTPVLPTAALETDYTVTLQAPSFVTSEHAVKIVIVALNDSSYVTLQDAGIHTSFSLKQNDVQIISSTSNDFSGVRVHSRDKIAVFAVASAGFFQRSYQLSANQNNYARSVFMQVVPFDNSALRYILVPMLQLHSIVRIYARDDNTSVTLDGFGSPKTVHVYKEIFYETSFDSRYPFEITSTKPIIVTQTPILDHGGGKLFTLTVPAVTQYSNEYGIYGATHAYVFIPSSESSGILVDAKPLTHVPDQLTIQTVNTDYVVMSVPLSHGHTKLSHIGQRSFGLLVYNDALKRTYIYSPRYNLHSIDCFPSIGSLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSY6</accession>
    <name>A0ABY7DSY6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="111" mass="13125" checksum="A728F652D27DB70E" modified="2025-10-08" version="1" fragment="single">MENPITISTDRGSQEEVACTTYTYLCPRKGEIWAREETRPPQKATPNRRLCEIKKIRAELRSLRKRYRCSSDAEKEGIVQLREQLRARLKALTNAERLRCKREAIFQKLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DT09</accession>
    <name>A0ABY7DT09_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Alpha-galactosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_022463</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF83">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045818935" description="Alpha-galactosidase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="9">
        <location>
            <begin position="323"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAQ98090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="407" mass="45606" checksum="2C0382BBC43BF359" modified="2025-10-08" version="1">MLDIANVLAVVLLLTSVRGLENGLARTPPMGWLSWTRFGCNIDCDSDPDFCISEKLIMSMADRLASDGYKAAGYEYVCIDDCWLAPERDIFHRLQPDKRRFPHGMKYLADYVHSKGLKLGIYEDFGTKTCGGYPGSEFFLQLDAKTFAEWGIDLLKFDTCHSDAHDNKYGYPAMSMYLNQTGRPILFSCEWPYGELQQNLSSDYGPVRETCNIWRNFWDVSDHFDSVKSIVANYGKNNALFQKYSGPGGFFDPDMILAGGFGMSSYQQRAQMSMWAMLSAPLFMSNDLRDISPDARRLLLNPLLLAVDQDPMGKMATKLWEFNNLQLWVKPIVPEGSLAVTFLNTNNFGSGSPISSTADSLGLTDSRGYNVTEVFTGKNLGVLKPTSVIKTRVFPTDAYMIVCILMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXR4</accession>
    <name>A0ABY7DXR4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_008008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="344" mass="29297" checksum="CA3710DB709F6FE7" modified="2025-10-08" version="1">MVITVIDRSGGSDGSLGGGGGGFVGGGSGGLLGGSGGGFSGSGSGYMDDGYIGGGSVGGGLAGTGGLGSGMFGGGIRQSLSGGIGGGSVDPGFGMPAHSYKQMGGHGMFGSGMGGIGGFGGGAGIGSGVAGLARGGGSVAGGGMFGGIGGKGGLIGGGAGGRGLIGGGGIGGGGILGGGGSLGGGSMIGGGGILGGRGNLGGGGIIGGGGNGGGAIMGGKHGFIGGGGIGGGGILGGGGMIGGGGKLGGGGILGGGGMIGGGGILGGGGMIGGGGILGGGGMIGGGGILGGGGMIGGGGILGGGGMIGGGSIGGGFGKYGRGRIGSGIAGIRRRRPNRRLFKMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZK1</accession>
    <name>A0ABY7DZK1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="106" mass="11947" checksum="C2F58B8F86A38212" modified="2025-10-08" version="1" fragment="single">MTLRFCIKLNWECCISIGDDEENRENAQNNNVEFSLGRNSENNSQIFANSPPPPNYSQLEFDQAVSDSANGNTELRETTIETTPSSDTVTQPPSYSDVIRNEVDFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1J3</accession>
    <name>A0ABY7E1J3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR03883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="211" mass="23060" checksum="22F0F90DD05E9B1E" modified="2025-10-08" version="1">MGFKYSTWNFLEAGHGKGAPDGVGATIKRHADQLVNGKGMDVMCAADLMDGLKDTTSIPMFEIKEEAVANYERQIANVTIPAENPGGSSGGSSADVFTDGFIQSTNDPFRTLVLSDSLTGSYCVVDYEGLPYPGLIMDVDEDTVEVTAMCRIGPNRFFWPLTAYGTAKKKLITLLEEEPALVTKRHRHIDSCMWKRILEKMGLDEAGKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1K1</accession>
    <name>A0ABY7E1K1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EMIL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_009642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF33">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="C1q" evidence="3">
        <location>
            <begin position="31"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR03084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="184" mass="20174" checksum="57826004F6948137" modified="2025-10-08" version="1">MKSNEKHLEERVMKLEYANKENEAGKSRRQEYRGSVSFTAYLSHSVTNIVHNTPVVYDTVLLNDGAAYDPLTGVFTAPLTGVYLFSVSSGSKNLPGSNLTQYDVFTRLVVDGVHKLSAVAESKNVYDDEQGSTTAILPIQKGSRVWVFHQITGGHSLFAEDGERVTSFAGALLYETESIAHLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1P9</accession>
    <name>A0ABY7E1P9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GOLI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_009311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="214"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR02753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="245" mass="28032" checksum="6824E66590F5E557" modified="2025-10-08" version="1" fragment="single">MEEQEQQDRMFALAVQESITQEERAKRGGQHCRNRGRGSFLHQNRNQRSRGIGRGQGQDRTHQGTFDHELALSLQLEESERKPAWNSDGCTLKDSLTQAEMAQRNGQHGRNRGWRGFRNQICHIFRGMGRGHGQERTHQKTVDHKLALSPHREEDKKKGVGNRDDGARPNVVPPVAPQSAELEERNVARGLTTKECSKLPTKRYRQTDRQSEGCSVCMEEYKTGDTQKTLPCLHVFHDSCIDPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E270</accession>
    <name>A0ABY7E270_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 53 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_009476</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="10">
        <location>
            <begin position="81"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="11">
        <location>
            <begin position="717"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="378"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR02918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="859" mass="97044" checksum="6DC6B5F468F078BD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E274</accession>
    <name>A0ABY7E274_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="201" mass="21072" checksum="ACB614C1D812F9AE" modified="2025-10-08" version="1" fragment="single">CSIFNNSTSGGSNFNNSSSWCSYFIYSSSGYSNFNDSSSGYSNSNNSSSGYSNSNNSSSGYSNFNNSSSGYSNFNNSGSWSSNFNNSSSWCSNFNNSSSEYSNFNDSSSGCSNFTNSSSGGYSNFNNSSSGYSNFNDSSSGCSNFNNSSSRYSNFNDSSSGCSNSNNSSSGYSNFNDSSSGCSNFIYSSSGCSNFNNSSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E303</accession>
    <name>A0ABY7E303_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MITOS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_009367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR02809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="213" mass="23866" checksum="81995EB911245C26" modified="2025-10-08" version="1">MHSYPFLNVVRYSKVTRTFAIRTNNVHYIQGIRSLWLKQSATELKQSTTSGTSAISKYLSLRNKLLIRIRQSALRKSNISSQDSSKTVSLLTKLCTVSGLTLGYAALNAKTLECETKTKSSRLDGINNERQVNDDVPFDWKQFAQLLWQDVLSLTLAVLCAFAAALVNIKVPLLVGEVVNVVSKFARETDCNFIEEIKQPAIKLIGTYFIQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E382</accession>
    <name>A0ABY7E382_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MMAB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_009806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213:SF0">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE MMAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cobalamin adenosyltransferase-like" evidence="6">
        <location>
            <begin position="105"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR03248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="199" mass="21930" checksum="49D00C6D92B76B37" modified="2025-10-08" version="1">MAEYTSRNTSGELGNSAGSINSNHEQYHLVEPMSASKHTNPSCWSSDLTISTTSWLVSGLSKVKAHPPPPAPVSLLWRSYREGKSFFSGLEIRSKLLLISRGMKIYTKTGDKGTSATFTGERRRKDDLIFEALGTTDELTSAIGQAFIILAKEYCKDAGHPFLDRLDEIQCILQDVGSNIATPKSSARESHKSQYDNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E723</accession>
    <name>A0ABY7E723_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HARB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="258" mass="28772" checksum="D1F0BDCFCF6D5F5B" modified="2025-10-08" version="1">MVKTFMLLIVSALFKERLELTYFRQSFLMDRIPNLDQLLESEIIDRYRFDWNGINFLEELLGAYIQPKAPRNKALSVKQNILITLRYLATGPIQLNDGDIHGVSQPTVSPILTEVIEVLSSPTLGIEECERNALQFRGIARFRKVIGAIDGAHIHVVSPHEQENIYMCPQHSVQVIFDGSYNIIDVVAPWPGSVHDSVIACCVLHNICKQRAIPMAAVAVNNDGGNGDDGRPQPQANNLVGLGYRDHFVSSYFGTLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E833</accession>
    <name>A0ABY7E833_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_020486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897:SF2">
        <property type="entry name" value="OS03G0226600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897">
        <property type="entry name" value="OS10G0105400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1641"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3166"/>
            <end position="3237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="3181"/>
            <end position="3232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR05117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="3272" mass="367724" checksum="7D0996699B0F0D66" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E919</accession>
    <name>A0ABY7E919_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HARB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="161" mass="18193" checksum="B36B4B2C07717D72" modified="2025-10-08" version="1" fragment="single">MADRQLDRYYRYRRFRLPRRPRVFTDRNNPLEILDVESVRKRYRFFPDSIMILVGIVEPTIGTATMRSNPLPPLLTVLCCLQFFATGVSRSAVGKAIHAVSVILAGLLNRYVKFPTGLEIESVKRKFNSVAGFPNVVGAVDGTHVKIQAPPDNEADYVNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAN7</accession>
    <name>A0ABY7EAN7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="188"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="286" mass="32317" checksum="A5A104D30D577700" modified="2025-10-08" version="1">MRGETIDITCTSTFARPPPRLDIFVKGNFSITVRTNLSIVDISKGIFKTIAKHSSNNSRWENEELLCRQSADDEGLFNSILSHAVHIDYIYPPSALYLTYTIPMRMREELVVSCTAIAAHHVCKSKWNFKTENMTYSVVSKDFTNNTFNEVISFNTSAFDLKSEIYCSVKCSEFVLTNSTILIFPQKPSVRIEGTTPAPPYNIVYLNCLSDGYPDSNITWEMVDPENGTKVEVLEVCDMPTCTLKIVSSSVDLMYNCIAQNKFGRASNTTRIMVSQRNDEKTEQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBD7</accession>
    <name>A0ABY7EBD7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="209" mass="23555" checksum="1DEEC1CFBF1C8413" modified="2025-10-08" version="1" fragment="single">MNYNLLFFKIHDSNTENEADCRGAVVEVLQTKLGIDHSDAENNEGIEAVMRAFDEQQDTYETSYSKLDSQFTERELRNGIKHLKNGINRPVVRWNAIHFLLTIVATQGALVLTSDQQFAQLQGDITLTCNTSVTSVEFKKDTKYVGRCSTFGCETSNTTKFLLIGNTEPAGYNVFSLTIMDFLVNDRGYYTCLNSYLIEQVSGTHITYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBV3</accession>
    <name>A0ABY7EBV3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABI2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_022028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd11826">
        <property type="entry name" value="SH3_Abi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028455">
        <property type="entry name" value="ABI3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF116">
        <property type="entry name" value="CAP, ISOFORM AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="154"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR06659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="561" mass="62367" checksum="B2BEA449B5876C88" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDU4</accession>
    <name>A0ABY7EDU4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BUCC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="254" mass="28616" checksum="13716AD5932586B6" modified="2025-10-08" version="1">MKKEGLVKVEEKGSSNTLLIVIICGCCRIGVRVSWSLLLCKQKATERIKDVFQSSTVFETCSEIQESSYCTINDVGNYERLQTFPISNADYKTIQCYDVDTDRYVKPRRKGSLDTDGYVKLTGKRSLDTDGFVKPTGKRSLNTDRYVKPRRKGYLDTDGYVKPAGKRSLDTDGYVKPTGKRSLDTEGYVKPTGKRKRPLDTDGFMKSTGKRCLDTDGYVKPKGKRSLDNDGYLNPRLKGSLDTDGYVKPNGKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEC5</accession>
    <name>A0ABY7EEC5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_016712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="214"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR06754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="255" mass="27830" checksum="590E482DF913016F" modified="2025-10-08" version="1">MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSASIGLKSKTHAILVALKRAPSELSAYQKKILPIDDHVGVAIAGLTADARLLSNFMRSECLNSRYAYDQSLPVSRLVAAVGNKSQVLTQKYGRRPFGVGLLIAGYDSQGPHIYQTCPSANYYDCKAMAIGARSQSARTYVEKHLEKFPDSSLEELIAHGLRALRDTLPSDLAMVEGEERSNRALVVDAPAQEGQEPMQQDAEGGAPDPAVADPAVQQPEGMDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EG72</accession>
    <name>A0ABY7EG72_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTPRB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF553">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 10D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR09007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="178" mass="20883" checksum="8F3E0E5CB732BA5A" modified="2025-10-08" version="1" fragment="single">GYTSPSEYIATQGPMLATFDDFWRMVWEQNVDTIVMLTKLIKCDKYWPDVNEPVYYGDLVVSVTSESNLSDYTLRIFEIKMGSKTRKLKHFHYLQWPDFGCPERHWPLINFVTLVRQYRPLFPTGPLLVHCSAGVGRTGTFIVVDHVLQHIRDHDEVDVYKLVLDMRNHRCNMVQTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EID8</accession>
    <name>A0ABY7EID8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="26" mass="2606" checksum="5122A92220B7B066" modified="2025-10-08" version="1">MAGTCWLALKLAPAQKVVGAGTNPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJI0</accession>
    <name>A0ABY7EJI0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SH3R1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_018899</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="37"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR08941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="315" mass="36619" checksum="7BC95F57A200A8ED" modified="2025-10-08" version="1">MRPPKGNKCKQSRTKMATADFPNEEIKIVINEDLITCQICMERFESPRMLPCQHTFCKTCIEAVIKKRCFGEHECNVFDCPVCRLQCKTGNGRTDMNVIMNDFPANRLMNELLEGIETYANYANTEAFNSNIDEECPQNASKKVQLYLWSCHCFLEVFRQYMHACFRLRWIKGQHLALHDAFINRKLASMFSDIVLTLFYKDNDDCILHQGIIATALEVSVPRNLNLDDRIQAIETIQTNTELMAYYFDKDLIDKSFVKEIAKSDWVKMIHYKDQCQQTNAGKLDLMFIAFRSLGFSNVFSISTLAMFMISKFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EK21</accession>
    <name>A0ABY7EK21_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTPRD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="58"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="161"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="616" mass="68984" checksum="5E772F596435CBFF" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELA9</accession>
    <name>A0ABY7ELA9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">inx</name>
        <name evidence="11" type="ORF">MAR_034880</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR09804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="531" mass="61610" checksum="29460A8D5CE63ADC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQY5</accession>
    <name>A0ABY7EQY5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NSUN2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_025845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="81"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR11665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="649" mass="74145" checksum="39AF6610CD220EAA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESC0</accession>
    <name>A0ABY7ESC0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PIF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_026009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR11829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="430" mass="47582" checksum="39B8AB75EC380331" modified="2025-10-08" version="1">MDNILPSPEMISVTFIAAFFVGAALVSAGKYDYLCVENNYANSVNFYNHPKDCSKYVQCWKNALGAFESIEQQCGFGTYWSMDDMSCISAVKVNCDEDACLGLMNSEHRAAKGNCRGYWQCMGEKSVPMCCPSGQHYNSTYGCEDNINEECTADCFGRYVAPVVITNETESENNTNALQDLTTTEAPIMCNKVGVENSPSSYTWNVNGRSFSMKCPAGTVFFQNKCDCLSSKTAARTCEPELLLKFNNGLLDESRNQIDVQNVSVLVENGEAIFDGATSQLVIPFFTNLEIKDTLIVRMKYTSDHTEIPDGEQRALFSNFDCTVNPSIQMTENSQNVVALVGTWKQFGASVAVPQIPLDANETVSEKDVTYKFHNNQLSLTVGPQPVEYVEVEGQLRKVQCALHIGYASGMLNFKGRIDEFAVYQCDPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESY9</accession>
    <name>A0ABY7ESY9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="85" mass="9885" checksum="0B72CF1AF8553208" modified="2025-10-08" version="1">MPTVEYSFEQLIMEAFERAEQWLSNGPTCKGPPWDNLEEKVEAARFHKNKESANSTSIMSKNRKKKNSPSFMSKQGEEKINKFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETE0</accession>
    <name>A0ABY7ETE0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF13">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="2">
        <location>
            <begin position="17"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="327" mass="36589" checksum="157D1F67098D2AB7" modified="2025-10-08" version="1">MPLTRKLQLWLRRNAENGNAYIECASTLNQRIECWWGYLRRQHVQYWKNKLRQLQEDSEFSGSAVDKSLVQFCFMAILQSELSLAVTMWNNHSIRRCRDSNVPCGQPNGMFNFPELWNIRDYMSFASREEVDACRGQVEFRSTVCCDPVVYDMCSYIMAADNCLPPNTFDEAELVQQRRDRQSVLRGRPAERQRAGPTKRVPGTSGCMTEGGTDKACSGDVWLYDRGRDRQSRAGPTKRVPGTSSFATEGGTKERVAVTSGCMTEGGTDKACSGIVRLGNRGRDRQSVFQGRPAVQQRAGPTKRVPGTSGLATNGETVDVCVTALLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETM8</accession>
    <name>A0ABY7ETM8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SEH1B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_026474</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR12294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="232" mass="25604" checksum="84F50F3B1FB5868C" modified="2025-10-08" version="1" fragment="single">THSGSVWRVTWAHPEYGQVVATCSFDRTAAVWEEMVGENVVEGEHRSWIKRASLVDSRTAVTDVKFAPKHLGLQLATCSADGIVRVYEAPDVMNLSQWSLQHEIPCKLRCSCLSWNTSRRHPQMLAVGSDDPNPSAGGKVQIYEYNDATRKWNKVETIAMVTDPVHDVAFSPNLGRSYHLLAIATKTLKIISIEPLRCGEYVGMFLAQCSSHLVMTAVFACGKEIILATGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETU8</accession>
    <name>A0ABY7ETU8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lipid scramblase CLPTM1L</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cisplatin resistance-related protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Cleft lip and palate transmembrane protein 1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_026158</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a lipid glycoconjugate involved in post-translational modification of proteins. Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = 6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)</text>
            <dbReference type="Rhea" id="RHEA:71495"/>
            <dbReference type="ChEBI" id="CHEBI:190691"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out)</text>
            <dbReference type="Rhea" id="RHEA:71491"/>
            <dbReference type="ChEBI" id="CHEBI:57997"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR11978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="345" mass="39727" checksum="0F5C871E9FBF6A65" modified="2025-10-08" version="1">MMKPSFTTVLAGLFISYMAYSMYTIALIFFPTHCKETGKKVMCLQPYTLKKSDFETRRNGTMFLHAFLYPKKHDPFSSKYVSYIQVPITTYMIPQSSVFNLLRDDAKDIKMPSLTKNQGSPVTHWRSKVTVSVMEDQIAFDRMAVPTELVNKTVDILSLTVTYTPISVGKLRMWTNMLESIKTLHSLDTMVGLSTRAVVWRCVSQSIIFLYLLDEETSLLVLIPAGISTIIEAMKYLSYVLYPLCIGGAGYSLMYVQHKSWFSWVIQSLVNGVYALGFLFMLPQLFVNYKLKSVAHLPWRAFMYKAFNTFIDDIFAFIITMPTAHRLACFRDDLVFMVYLYQRCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EV92</accession>
    <name>A0ABY7EV92_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="77" mass="9013" checksum="1F462001DB5AEC16" modified="2025-10-08" version="1">MPDAFCELFRPPCLQIEFACRDYSLIVGYTFTKLVKRDLFGRRYSTLTEGRPMETASIYCVSLNDPTNDGYRIVRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EW26</accession>
    <name>A0ABY7EW26_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZFAT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_027675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="493"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="598"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="874"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="930"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="958"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1008"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1037"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1065"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1093"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1170"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="283"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="752"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="723"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR13495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1350" mass="152117" checksum="780F4172BB03D663" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWK4</accession>
    <name>A0ABY7EWK4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_027679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="241"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR13499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="573" mass="65738" checksum="97BFAE04C0E419A0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EYI3</accession>
    <name>A0ABY7EYI3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZN236-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_026401</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051643">
        <property type="entry name" value="Transcr_Reg_ZincFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24396:SF19">
        <property type="entry name" value="FI01119P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24396">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="567"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="600"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="687"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="715"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="743"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="771"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1021"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1146"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1174"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1203"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1231"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1588"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1690"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1718"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1746"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="927"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1662"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1795"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="488"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="958"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="977"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1669"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1805"/>
            <end position="1816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR12221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1843" mass="203450" checksum="EEDF237C5BDB3E18" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZ20</accession>
    <name>A0ABY7EZ20_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="501" mass="56368" checksum="A599A83CFDE0FEDD" modified="2025-10-08" version="1">MWTENASGNTRQGIPQQQLVWSQRCIEDYQRHMKEVDLIDLIMGYYMSTTDQASNGLVTHHMQITAAHNSYIISQDSNPEAIQREWPKYQDFIEDLVKDLIGNYKASRAAPLSYIEKWHPFLVHNMTFSGDCTGLCCKYLADAVGAASTCWMQLEQQVRVGCSWSSKYVLDAVGDAIGDASMCWMQLEQQVRVGCSWISKYVLDAVGDASTCWMKLEQQLEQQVRVGCSWISKYVLDAVGDASMCWVRLSSKYVLDAVGDASMCWMQLVMQLLMQVRVGYSWSSKYVLDAVGSASTCWMQLVMQVCVGCSWSSKYVLDAVGDAIVDASTCWIQLEQQVRVGCSWISKYVLDAVGDASMCWMQLEQQLLMQVRVGYSWSSKYVLDAVGSASTCWMQLVMQVCVGCSWSSKYVLDAVGDAMQQEIRLMIVAIVAALVLLLTTARAEGCSCHPREPKEVFCNSDYAVVLEVVNVSEPFYSDNMDPGPWSMPWVDYGIEVRMDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZ28</accession>
    <name>A0ABY7EZ28_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galaxin-like repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056601">
        <property type="entry name" value="Galaxin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24748">
        <property type="entry name" value="Galaxin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galaxin-like repeats" evidence="2">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR14127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="255" mass="29541" checksum="8C6308CFCCFDCFA2" modified="2025-10-08" version="1">MYNYTSQTCCNNTTLNGDQGCCQGHTSYILKAEECCENKVINRSKELCCKNNIVTKTHPSHYRCCNINRAWTTYNEFDPPKECLLTHIRKTLRNNPTKTGRRSGGNQIAESETTERSPLEECPFTECFDREQKQRSTCKKFFEMDLFLDDVNFTDDGSNLNVTIIQPDEFVNKKVTIVLPYICPCLDSGHVYTLFTNKGWVRKLTIDGKLEFTKFQTIKKNDFLVRRGSGADKFTCTIRRKYSAFYNSWRASPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZA2</accession>
    <name>A0ABY7EZA2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LEC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd23417">
        <property type="entry name" value="beta-trefoil_Ricin_MytiLec-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="285" mass="31558" checksum="ACCF9504AE800791" modified="2025-10-08" version="1">MSEPFLIKHRSSGKFFHPDGGKSNPGNGTSVVLHSDIHANMHWRFRKETDYWGYIEHVASGKCIHPNGGSLTPGNGTRLVVHSARHYGALFALDGKNDHVIHKGGRYAHPDGGRPDPGNGTTVVLHSGIHDAMRFQFVSPKDPSKEILVYGTPNVIGKWEIINAVINPKAEHKSTISVKIGKSKTESTTSTFEYTWESSFGAAFKAFSASVSQSVRFMVEKTSSNTWSQETTRTKEITVSPGKTVVTWQYKFAVEQNDSRALFQSNLLADTESETTEPRDFKYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F047</accession>
    <name>A0ABY7F047_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DMSR1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_005663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF4">
        <property type="entry name" value="AT19640P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="78"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR15558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="407" mass="46216" checksum="5EBED4F2DED5E3FA" modified="2025-10-08" version="1" fragment="single">AHRSFAKAIAVNLKESSYFSQAVHGNKYYEIDVAMNVSYDLDYVDNTTDFGRLGQFYQAYAGVHGYVSVCVCLFGIVTNLFNVSVLTRQSMRTPVNELLTWLAVSDVMTMVSYIPFATHFYIRSPSSGDGLPERNSRAWMTFLVAHVNLTLTTHTISIWMCVTLAIVRYHHITSPTETNVFRKRRIQQTRIMTVIVYILSTVVLIPNYLSNELQARSHGNQTVYYLADLGLGRPGTETTVLINVWLYAMVAKLVPCLLMAIFSGLLIYNIHFKVRHRRKMIIKSGNNNIRLNEHSRTTKMLIAVITLFIVTELPQGILIVCSATIHNFYDHVYQSLGDVMDIVALVNNSVTFVLYCSMSAKFRQTFVKMYCGRCQRSRTTVTDSIPLAEKRLNHVDSYSNIAVLLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1X2</accession>
    <name>A0ABY7F1X2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_030777</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF422">
        <property type="entry name" value="CADHERIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046919600" description="Cadherin domain-containing protein" evidence="10">
        <location>
            <begin position="22"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="297"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR16183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="600" mass="64595" checksum="950B192DC59A5C86" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2D6</accession>
    <name>A0ABY7F2D6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_005444</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR15339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="255" mass="29648" checksum="432147E814463C9E" modified="2025-10-08" version="1">MANLSQNLKDYMSKSQSKEPLLLTENESSGSFSFSKLNPFRKSQIDSYEDTNAVANGWFSQAQKDPFFPGLSKKQRILGFACLYIPMLVLKARKFAMLYTLGSLFIICSFSMLWGPWNHIKHLFSQDRLPFSLVYFGTMFATIYFSIWVRSTVMTVHYELYTWWADRHEVFLESVLCCSLKDYPKCSPCLGLVVHYILVQILITWGVLWILFVKKKHLLCLISGILFTYQYTSTFLPRNTLSTFLREVLDTFSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F6C6</accession>
    <name>A0ABY7F6C6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZN202-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_032049</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR17455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="184" mass="21327" checksum="C8EED2D844C14472" modified="2025-10-08" version="1">MIYYGISINAMGQPDNATMVKNYDLLNHLSVLACDICGKLHSNTFLLRRHMRSHTGEKPFKCDGCGFRCARQDNLKRHQMLNLMLMYPSQDDSRNPAMEEMLGRVIYQCKICGKVQPCPANLKRHMRTHTGEKPFKCDWCGYNCARKDAMTAHKRRCSMKKQLEQQRKLNIIQSDAILLFQVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F6F2</accession>
    <name>A0ABY7F6F2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_032079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="33"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR17485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="125" mass="14277" checksum="B89F4D7ECBE0BFFE" modified="2025-10-08" version="1">MKKKEEDSDFKENYKSNNLRKPCDSDKSNSRKQNVCDECEKSYASVSGTRGHMESRSHAIQCDVCERWQHRKCNTGVSHAQYRKLQKLEITIEWSCEDCKMTEMDTIVAAAVGSLSTISDIAAYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F6U5</accession>
    <name>A0ABY7F6U5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR17915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10741" checksum="77B0573CDCB8AC11" modified="2025-10-08" version="1" fragment="single">MLSCSVVDEAEVEYEVVEEGSNRKRQKLVSSDGFSYCVKKETDSSWQWKCSIRHKDMSCYASVNQRGEVFSRGAKEHCHPADPLRKKRVLLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7L4</accession>
    <name>A0ABY7F7L4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRPG-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="215" mass="24125" checksum="0372CD86FBD87D8C" modified="2025-10-08" version="1" fragment="single">PLQVRNVSRRLVHTHSTISDSSMPELGENGLKGRGTAPVLESNAKVGRREAKMNGHRRSLPGFSDVGNSYQKVLQRIVQRYIFDIQREAEVTEDDFEEIKQDLSSFRYEMMSMLKNQQLQEITTPSKLKRVINDLMYGGDEPVDRRRLVLSKLRKMQMSSGYTSGLGSVDDGDEGEDETIQVERGGCRRGDKITMNGGPGVHHPGSDIHHSGQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8H6</accession>
    <name>A0ABY7F8H6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CP2J1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_000306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF403">
        <property type="entry name" value="CYTOCHROME P450 306A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR18468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="487" mass="54873" checksum="9C55D9A4B7370318" modified="2025-10-08" version="1">MSLRSLFDSVASADGSTALVVTLTVGLGIIVVARMSTRGKSRGGGRPPGPRRLPILGNLTQLAGNGTFFEKLNEMRKTHGDVLYLELGAVKTLVVFGHDMVKRLLVDYADSFQYRPVWLVEIKSLQLSNGIVWSNGADNQRLRRFALPCVFPGVGKQTLEQRIQIEAEALMSQLHERSGDSATLKDLFFRAIGNINCSVIFGKRYEYEDAEFGEFLALMDSLLQRQGVKNPLNFFPILQRLPEGKKPKATREVLSKVSAFLHRKLVEARTDFDKDNIRGLLDIGECLPHCPGLFRGWHRKRGYCARLARYTARDENVQDTCRKCVKEFLGERSCPGMEDIKHMPYLEATVNEALRLASITPLSVPHATQEEVEFEGYTIPRDTMVLTHMQSVNLDPAYWEEPDNFRPERFIKDDAVVSKEAFYPYSIGPRYCLAAKLSQMELTIMFATLIKHFRFTTAAGAEAPSLRHTQPGAFVEPETFKVTWSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F985</accession>
    <name>A0ABY7F985_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_000433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR18595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="176" mass="20248" checksum="5F8C5BE8C8DC283C" modified="2025-10-08" version="1">MNDVKQFYQSGAFSIKDPNVRPEILPYIQWECRDFCWKFPAVISNLSEIYFTDASQYFDIAWETGVAITNYTFSSKDELDNIRMGLVEIGEGEQLLMDEAYLSMAVRNDTGRPNISPMLNVFPIYRVPLNSSIDIRLFPFDGDGDYVRCHFDTFPGPGSLESHIVLNEVYMKVNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAK6</accession>
    <name>A0ABY7FAK6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="181" mass="20401" checksum="3CAB4F7C934E9002" modified="2025-10-08" version="1" fragment="single">DRSDTFSSIHCLKQKISQYKVLQYPTIVDCLEKPPEVFILTILYTTDSSYSFCIEFRSGSVSAIFGFFKNDECFVIPFNGCFSDFAERQVLFAGLSKWVGSENKAERGVGVGQCVPCSDTQGYKRVYIHTVHSVSKSTAYRVLTPPVLKELPVKHFEQSRVAKEIIDIQKANAAKQYSKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FB42</accession>
    <name>A0ABY7FB42_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="212" mass="25249" checksum="A1129BE85531B35E" modified="2025-10-08" version="1" fragment="single">EYLPYILLTNQRVPTPHILLTNRRVLTLHTILTNQRVPTLHTHEKPESTYPIYYFDKPESTPISHIILINQRVPTLYIILTNRRRVPTLFILLTNQRVPTLYILLTNQRVPTLYILLTNQNEPNLYTILTNQRIPTLYILLTNHRVPTLHTILTNQRRVPILHTLDKPESTYPTYHFDKPESTYPTYHFDKPESTYPTYHFDKPESNYPSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBK6</accession>
    <name>A0ABY7FBK6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AOSL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_031270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020834">
        <property type="entry name" value="LipOase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00087">
        <property type="entry name" value="LIPOXYGENASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00081">
        <property type="entry name" value="LIPOXYGENASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="6">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoxygenase" evidence="7">
        <location>
            <begin position="116"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR16676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="661" mass="76037" checksum="ABB28577B9232375" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCX5</accession>
    <name>A0ABY7FCX5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_000474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR18636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="209" mass="23805" checksum="AF1B167BE565BDC6" modified="2025-10-08" version="1">MHSENWTRETCQIDISTYSKYATSRKTQVKRLEEKRKGSEEHKQEIADHDLKKRKDPANIVFNISTPSGIQNKCIIFLPPSLVRHHVSPVSMRQRKTLRQMTKLTFALEVSSSGREYARQVIDEADKNHVCDSILDDTIADDEFSDIDLPTLTTEIVQSNSTVQSTASVTTNYRIEHQMNVAQTILGSSQIINIPRETNNCDFNIAPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEH4</accession>
    <name>A0ABY7FEH4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">M4K3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_000999</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF18">
        <property type="entry name" value="HAPPYHOUR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR19161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="158" mass="17968" checksum="452795EB3F7D2E9B" modified="2025-10-08" version="1">MFPKAKERNSGELAAIKIIKLEPGDDFAVIQQEIIMMKDCKHANIVAYFGSYLRRDKLWICMEYCGGGSMQDIYHALVISGANILLTDEGDHPFLHGDLTRRCTREILDRVRNPQQTTYEIQPDDDDEFLANVPQRISSSKSSSRYNQARNSIELKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEI5</accession>
    <name>A0ABY7FEI5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VASH1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028131">
        <property type="entry name" value="VASH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15750:SF2">
        <property type="entry name" value="VASOHIBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15750">
        <property type="entry name" value="VASOHIBIN-1-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14822">
        <property type="entry name" value="Vasohibin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="425" mass="48514" checksum="179253CD2086C42C" modified="2025-10-08" version="1">MPKLVSNNDSPGDFGTLKRTTEASTDEPKTMKFKASKSPTMKSNGTQSSAHDSRSRPSTSTVNKEDQREENGVWFWVNKNGFPVDDVTWGRMWDHVAKIHPDGYKMVATVRANTNLPPIPVPQAPMNFSPTMPIPDRLEKIQNYMNALEYPCHLFYIKLMEVAKDMVRESLPIKCLEAIILGLNSQSYLTNGMMGMERFPIGFKTQFNGNYHRHVVLGIYHGGRYGALGMSRREDLMYKPLVYKSLSELITDYEKAYRNMTLTRSKLTQQELIKEVDSHAKEIRTKNTCSMFPPFKLKYKTSIRENKSGCVLCESCYFPLLYEREITAFEIGLSGFWKKNKENSLIGDRETSRSWSVPQTTSPRKSLSFVDLDSVRHSRSKTGQASHSSFNQAIKLYNGTTVSTDSGEKIKKKEPTDLVEYQIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEN3</accession>
    <name>A0ABY7FEN3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="308" mass="34193" checksum="96EE072E297F14C1" modified="2025-10-08" version="1">MNSVRFLPNVRSLAPSRAGCPASVNDQSCLTMAGFMPDVENWCLIFQGSDRAVVNRSVRYNYEVNIQRPASLVYYASYRGGGGDDDNDEDSDDDDDDDDDDDDDDDDDDDDEKLPDADTEHDTAPDTQMIVRVSGPEAGYVATGGVYTTAMLFRETSLIERLIKNNIKFAVVKEIFPLITRAGPKLPFLDVQKWCLIFQGSDRAIMETGTFSITVVGKGWKEKLPDADTEHDTAPDTQMIVRVSGPEAGYVATPIGWCVHNSHAFPRNKPYAGDVTARRYNLHTCALRQRGSDETKAYLTVKENEPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFC8</accession>
    <name>A0ABY7FFC8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001937</name>
        <name evidence="3" type="ORF">MAR_037353</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR23684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="173" mass="19618" checksum="4F7D0DCEAF4412B0" modified="2025-10-08" version="1" fragment="single">MKGFVNKVKTLFNKKEDNSRESWLFTKAGFIDTKVKMASIATRDARRLPSVPGKTRGQRILVPTYRHAVNWFNKNRETLDLITGLLEVHPSLIYQEPCTKLRNFLSAVHTDTSTRISDVFRHSDINDQHQVNSSILNGSETQKSMSVSNVPEILVSKPEDENSSLSDPCSTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFV5</accession>
    <name>A0ABY7FFV5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SREC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_001887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR20049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="650" mass="72789" checksum="C980DA91FEB63FC8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGG9</accession>
    <name>A0ABY7FGG9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pecanex-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_001807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pecanex family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039797">
        <property type="entry name" value="Pecanex"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12372">
        <property type="entry name" value="PECANEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12372:SF7">
        <property type="entry name" value="PROTEIN PECANEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="671"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="945" mass="103738" checksum="28B15B18D4E277D9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FI14</accession>
    <name>A0ABY7FI14_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21038" checksum="39E80D8FFD8DCF9D" modified="2025-10-08" version="1">MAWARCPTASVDDEVAGRRDEASVSYFEDGKHTAVLLKGIPENVHEEFIEMFFENKKNFSDVKVHSVCIDRDDRTAIVKFRDKQASDVVLEKECIIMKRANVHIESYHPEQQTQDVTRAENKTELPRVVLKDLPNAVDREDIEMLLCSKKRVGNIEVVDIDYNDEKSLAIVTLGNQECKCLPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKX0</accession>
    <name>A0ABY7FKX0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YCP9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF12">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046998289" evidence="1">
        <location>
            <begin position="19"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="260" mass="28710" checksum="D79205F3653648E3" modified="2025-10-08" version="1">MAALVSGVFIAMSATSIATVLVQGASRGIGLQFCRTLLSRQPNTCVIATCRNPNQADDLQKLLADEPERLQVLQVDVTEEAKIKAAAEEVGKRHGRLDLLINCAGVLHPSGRGETRIDGDMQNNRLWPSSDGQTFWPATDQRNCHVWNTPARLQANTLRHYGKHICQSLGGWYSYRMSKAALNMATKNLSIELGRGRTPVICVSLHPGTVDTDLSRPYHKNVKSLFTTEDSVKKLLSVVDSLTVDDTGKFFTYNKELLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLJ4</accession>
    <name>A0ABY7FLJ4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="9">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_036752</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="9"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd11845">
        <property type="entry name" value="SH3_Src_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 8" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="58"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="133"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR23083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="336" mass="38547" checksum="C746C5C6E255EC0E" modified="2025-10-08" version="1">MGCEKSKPKMDTSESKSSDIKGRSEENGDKPREKNDYTNPPVNLPQPGENSIVEGGSGGGKRVFALYDYDARTQDDLTFRKGDVLELIEGITGDNEDWCYARHTYTKYSNLQKEGYVPRNYVALEESLESHDWFFGQVTRKEAERNLLTKDNPVGAFLVRERESCPGSYALSIRDYDQNKANPDCVKHYKLRNMDGGGVYIVKRRQFKSMMELVGHYKVQADCICRSLAAPCSRAVPVMVDLSRDTQDAWEIDRNSLQLAQKLGAGHFGEVWKGMNNKEVLQQIADGYRMPKPLECSDAMYEIMLKCWDKREENRPTFEFMECFFDDYFANTELEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPT0</accession>
    <name>A0ABY7FPT0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SVEP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_037729</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050350">
        <property type="entry name" value="Compl-Cell_Adhes-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325">
        <property type="entry name" value="COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325:SF575">
        <property type="entry name" value="LOCOMOTION-RELATED PROTEIN HIKARU GENKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="62"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="120"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR24060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="175" mass="18394" checksum="E232781EB6D4DE45" modified="2025-10-08" version="1" fragment="single">MCYFCSDCGDPTPEYGSSNATTTVNGTIVVVNCHEGYILEGNAILSCQENDSWTESSICKIVDCGYPKHPNMDFTLSRNTTTYGSFAVASCSMGYGPAGSTTYKCLANASWGSFPSCEIVDCGSPIPSGGIANDSSTTYGTFVSITCTNGKVKGDSVIACRQDGTWSDYPTCNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQA2</accession>
    <name>A0ABY7FQA2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR23044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="72" mass="8367" checksum="6A2AA01DDDAA3019" modified="2025-10-08" version="1" fragment="single">SNIFPIPTHPLSVAQVTADWTMDKDDYKYSESNFPAYKVRRIKRSCELNQRFSSTQKNSTFVIATKTIDCLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRB7</accession>
    <name>A0ABY7FRB7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Y508-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_015735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057044">
        <property type="entry name" value="PARP14_KH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057051">
        <property type="entry name" value="PARP14_RPM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF102">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP14-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23084">
        <property type="entry name" value="KH_PARP14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23222">
        <property type="entry name" value="RRM_PARP14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="228"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="8">
        <location>
            <begin position="840"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR21761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1101" mass="123991" checksum="140850055A516EDA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRH3</accession>
    <name>A0ABY7FRH3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hydroxysteroid dehydrogenase-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_038484</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd09762">
        <property type="entry name" value="HSDL2_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051935">
        <property type="entry name" value="HSDL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006133">
        <property type="entry name" value="PRK08278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808:SF3">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="10">
        <location>
            <begin position="296"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="470"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="380"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR24815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="557" mass="59238" checksum="CFC5F67E1D57C1DD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSB9</accession>
    <name>A0ABY7FSB9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MKLN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_010819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052456">
        <property type="entry name" value="CTLH_complex_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010565">
        <property type="entry name" value="Muskelin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526:SF5">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06588">
        <property type="entry name" value="Muskelin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Muskelin N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR25115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="127" mass="14689" checksum="57FDB1DEE1437E76" modified="2025-10-08" version="1">MACKSSTLKFEIHKWSSYSYNYKPENVFLDKPADQSSRWSSDSNHPPQYLILKLEQPSIVNTVTFGKYEKTHVCNLKKFKVFGGLSDELMMELLESGLKNDHIPETFPIKNDIDGNHFPCRYIKIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FT63</accession>
    <name>A0ABY7FT63_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IFT52-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_038148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd23683">
        <property type="entry name" value="IFT52_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039975">
        <property type="entry name" value="IFT52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055460">
        <property type="entry name" value="IFT52_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055458">
        <property type="entry name" value="IFT52_GIFT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048643">
        <property type="entry name" value="Itf52_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969:SF7">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969">
        <property type="entry name" value="NGD5/OSM-6/IFT52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23352">
        <property type="entry name" value="IFT52_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23355">
        <property type="entry name" value="IFT52_GIFT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21178">
        <property type="entry name" value="Itf52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IFT52 GIFT" evidence="3">
        <location>
            <begin position="17"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="IFT52 GIFT" evidence="3">
        <location>
            <begin position="183"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="IFT52 central" evidence="2">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Intraflagellar transport protein 52 C-terminal" evidence="1">
        <location>
            <begin position="314"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR24479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="395" mass="44613" checksum="CEF78FA349AAB098" modified="2025-10-08" version="1">MAPTAEGMEEKTQRNIILFNASKRELFTPSSGYKTLNRKLRSTWKINTNKEEVTDERLAGSRIFVVAGSRDKFSAAEFDSMKRYLDTGGSILMLAGEGGESRFDTNINFFLEEFGINVNADAVVRTSYYKYFHPKECLISNGVLNRAISQAAGKSGSTVFISIWSDNFRHEASSSCPVNWQCISSGKLAVLGSAHMFHDQYIDKEENSKILDVLIRFLTTDEIKLNVIDADDPEISDYNMLPDVAKISDNLKTCLQESDDIPRDITTLFDNSLFKLDTSLFETPLPPLNPAVFPPQFRELPAPCLDLFDLDEQFSSEKVRLAQQTNKCMDDDLEYYVRECGDILGVTTHLAQDNRDAKHILEYIFSQVVEFKKLNQERDYDTVQYGGGSGAEAMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FT90</accession>
    <name>A0ABY7FT90_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABCA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_038023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABCA1-4-like C-terminal R2 regulatory" evidence="3">
        <location>
            <begin position="78"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR24354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="227" mass="25456" checksum="4F36A4F34CE8CC1F" modified="2025-10-08" version="1" fragment="single">MRRLTNNWHGPTFTALSMEPMEKCVALCTRLAIMVNGQFKCLGRIQHLKNKFGDGYTLSLRLKGPERTQDGLFSNTFRLQILKFELKSQDISLSYVFSKLEEAQTDLNIEDYSVSQNTLDNVFINFVKQQVEISEDFTPDIHASSTRSRAVSSTNISSSSSQDDEMLSDLQAEIPLETEDDDVPLLGFGGAGVDSLIPAQYGYSQHMIKKQFLNRDLLSIATVLAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVP7</accession>
    <name>A0ABY7FVP7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGRL2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_038592</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF347">
        <property type="entry name" value="FI21270P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047391116" evidence="9">
        <location>
            <begin position="21"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="687"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="732"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="770"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="818"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="846"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="10">
        <location>
            <begin position="33"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="11">
        <location>
            <begin position="468"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="12">
        <location>
            <begin position="689"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="889"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="889"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR24923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="934" mass="103821" checksum="EB91C2E9341BD413" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWF9</accession>
    <name>A0ABY7FWF9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR23516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="185" mass="19156" checksum="0C6040FA57750DFD" modified="2025-10-08" version="1">MAKEWITVTGEASLTLGAVTVVKEWVTVTGEATQTTGALIVVKEWVGNSDRRGNTDGGRGRSGKGVGNSDRRGNTDDGRGHSGEGMGNGDRRGNTEGGRGHSGEGMGNSDRRGNTDDWRAHSGEEMGEATLTAGAVTVEKEWVTVTGDATQTTATVTMVKKVVTVTGVATVTTGAVKMMTEGNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FX53</accession>
    <name>A0ABY7FX53_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATS3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038877">
        <property type="entry name" value="THSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311">
        <property type="entry name" value="THROMBOSPONDIN TYPE I DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311:SF3">
        <property type="entry name" value="THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046919621" evidence="1">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="93" mass="10104" checksum="CC425D81AF9D18F9" modified="2025-10-08" version="1">MRLWAVLAAYLCVPIATGADVDGEWSGWEAWTACTTTCGTGVTFRTRHCDNPAPAYNGSDCPGLNQDFSKCLVKHCPSKHLLISYCTFTGTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZJ6</accession>
    <name>A0ABY7FZJ6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translocon-associated protein subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Signal sequence receptor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_012278</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAP-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008855">
        <property type="entry name" value="TRAP-delta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12731:SF1">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12731">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, DELTA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05404">
        <property type="entry name" value="TRAP-delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046329952" description="Translocon-associated protein subunit delta" evidence="15">
        <location>
            <begin position="23"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR26574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="159" mass="17083" checksum="7CFDCE4E5DF02356" modified="2025-10-08" version="1">MIVAGKTIFAFMLVIAPFMVLADVCTSPSVKSSTYTTSEASSSTNTVFIVQFSLSCKNGAKVQVTLKIESVILAEVNGNTDLTLYADINGKTVPVSFSDENKNLPSGSYDVKFYDEDGFSNLRKGVWKGPLVPSELVATATAVLVWFLAYSARNSLQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZT7</accession>
    <name>A0ABY7FZT7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ZNFX1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_013427</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RZ-type" evidence="10">
        <location>
            <begin position="1801"/>
            <end position="1875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="847"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1913"/>
            <end position="1932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2045"/>
            <end position="2089"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1624"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="848"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR27723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2327" mass="266644" checksum="14ED71AB4CF91334" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1C2</accession>
    <name>A0ABY7G1C2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="25">DYH12-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">MAR_012893</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">MELC-2E11</strain>
            <tissue evidence="25">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR27189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF70">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 2, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="16">
        <location>
            <begin position="703"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="17">
        <location>
            <begin position="1276"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="21">
        <location>
            <begin position="1769"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain 3 AAA+ lid" evidence="22">
        <location>
            <begin position="2133"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="19">
        <location>
            <begin position="2254"/>
            <end position="2362"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="18">
        <location>
            <begin position="2427"/>
            <end position="2767"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="20">
        <location>
            <begin position="2800"/>
            <end position="3030"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="15">
        <location>
            <begin position="3272"/>
            <end position="3368"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="23">
        <location>
            <begin position="3396"/>
            <end position="3540"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="24">
        <location>
            <begin position="3548"/>
            <end position="3829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="778"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2655"/>
            <end position="2703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="787"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="WAR27189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="3833" mass="436570" checksum="230CE5CF159DF626" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2I9</accession>
    <name>A0ABY7G2I9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CLCA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_013226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013642">
        <property type="entry name" value="CLCA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF177">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08434">
        <property type="entry name" value="CLCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047116038" evidence="2">
        <location>
            <begin position="16"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="686"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="306"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR27522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="726" mass="79981" checksum="7DFD14C66218D08E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2N1</accession>
    <name>A0ABY7G2N1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="405" mass="46173" checksum="B0ECF76FB108DFFE" modified="2025-10-08" version="1" fragment="single">TSSDVISDSSFSDDSAKIKHTQSYPHSQLRYEFVTQNIGFEDLTFNLFVAGELEIISNPTTSAKEKTGRLSLLKRIMYLNAHFTFQNLKAFYAAVLREIELGEKNWGDDFHYLETCILNKPYPSSDKPGQGSNPRVKSWKFSDSTVADEERSASNVWFCTFFKKKMYAQGYPLFVCKVLKPTEYRSEIADLVRTHELVKRSGKFNFEGCRIKINDKINTDYLRCLFANFEYKDTAVCDLLEFGFPIGFVGNEDCFQKCKEAWQYKTYKGAEEFPVQINAYLRKELEFKAIIGPFKSNPFSSNLLISPLNSVPKHMSGERRVILDLSSHSGGSVNDFVPKDVYLGESVTLMFPKIDDFVKLVLAKGAERPEMAQFAYNTLGTLLLKCGIEESHKKSFPPSDIMSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3Q3</accession>
    <name>A0ABY7G3Q3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="1">
        <location>
            <begin position="57"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="139" mass="16531" checksum="19E96393A1CA0BD0" modified="2025-10-08" version="1">MKGFVVQKSRVLDSMKRVEIEGVLQGKMLLKPILRRQYNVRAPLSLWHMDGYHKLIRIERLWRDVWDGCIGLFYKLFCMMEDTGILLPQNDDHLKALHYIYLPRIQQHIGYIPQRIHQETLENCKQQDTNAALDIRVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5J8</accession>
    <name>A0ABY7G5J8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-Fucosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_003286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">Golgi stack membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 11 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd11301">
        <property type="entry name" value="Fut1_Fut2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927">
        <property type="entry name" value="GALACTOSIDE 2-L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927:SF9">
        <property type="entry name" value="L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR29718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="397" mass="45454" checksum="F9AB95B329932838" modified="2025-10-08" version="1">MVSLKYVAICFLFGELQYRMGHGEVEGDLLSFTPKVETQYHTNGKRTIGVYVLDLLRKRQTAKDKADTTLFHTSRANNQSNAVDDTCFDLAWRYNIRLRSECEYGVQSSVRYGIRNSPPMKGDSFKKNEVPDVKPESSYTTERRTGNDMFQVAALIGIAKRNGLIPLLNDRLSKMDWFYFPDLNFDFPLENVKKHHVEMPGVYADGTANLNPAYNWTVRGYLQSWRYFENAASVVRQIFKIKSVYMAPAKDFLNSISKTGYVNVCLHYRRGDMLMTSAIRRGYTVAGLDFVAKAMTFYEQKFTNVTFVVLSDGIQWCRNNIKKSNVVFSPFEVAAIDFALLTSCDHVIVTSGTFGWWGAWLSRGTTAYYAGYPGVNTWLETKMDRSDYYPNDWIGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5T2</accession>
    <name>A0ABY7G5T2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_014366</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd19343">
        <property type="entry name" value="Wnt_Wnt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF102">
        <property type="entry name" value="PROTEIN WNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR28662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="328" mass="36644" checksum="B812D23385CBB222" modified="2025-10-08" version="1">MADIRALYRNRQKTWTNGKECRKSYGLSSQQIKLCQGHLDLMGTVAIASGKGIDACTRQFYDRRWNCSSLSQAPKLTKDLKRGTREQAFAYAMASAALTHSIARACSVGITTKCSCGKLPSEAPTGDYKWGGCGDDVEFGLRFSELFTDYHVDKTSKKKKTMMNSHNTAAGNKVVYDSLTTACKCHGVSGSCSIKTCWRSLADFDDIAETLKDKFGMAIEVKRKRKGEFHKFVPRYKKMDSIPMDELVYVSKSPDYCSPDRKLGSIGTKDRSCDPDSTGPGGCDIMCCGRGYESSDVTLVERCECKYYWCCYVKCKTCSKTLRVHRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G841</accession>
    <name>A0ABY7G841_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FCN3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_003645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="76"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR30077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="319" mass="35959" checksum="BC1805ABB18D769D" modified="2025-10-08" version="1">MERDANNQFPMALSSSVIVTIVFIGAVCLNLALASGSCVDLDVTGCRTNPQLCQDPLIAEVTCPVMCNRCPNVPQTTQADTTADCSDLLKRGRSWSSGVYTIVTWKTHTTVDVFCDMDTDGGGWTVFKHRVNGSVDFYQNFSSYENGFGSPHGEFWLGRRLLNIRKDISNSNMFQYCFKLIGLRLLNELTSRRNHTLRIDLKAHNGTRMYDVYDGFSVGAGSNYTLHVDHRVDSLHLPYGHLLSPYHDGQPFSTYDHDMDQHSSSSCAITYHGGWWYNGCYAANLNGRYFVNGFPYYTGMVYMPFATFESVKKSKMMFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G851</accession>
    <name>A0ABY7G851_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HMCN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_033140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056475">
        <property type="entry name" value="GBD_Hemicentin/VWA7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056861">
        <property type="entry name" value="HMCN1-like_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23560">
        <property type="entry name" value="GBD_Hemicentin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25106">
        <property type="entry name" value="VWA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046172779" evidence="6">
        <location>
            <begin position="30"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="458"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="557"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="559"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR30598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="644" mass="70929" checksum="A97A4D24164D4434" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8E8</accession>
    <name>A0ABY7G8E8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZN227-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_002879</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR29311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="285" mass="33755" checksum="214BA091F38DD210" modified="2025-10-08" version="1" fragment="single">KPNKCEVCAAAFSRKDQFKIHVRIHTEDKPYRCVVCDAAFPQKSDLHQHKTIHTGESTLKCDVCDATFSRKSNLQQHIRIHTGEKPYKCEVCAATFSRKSNLQQHVRRHTGEKPFMCDICAAALCQKNDFHRHFRIHSGVKPYSCELCDAAFYQKNFLSERSVTETYVHLYTHGIHAAAFSLKSHLQQRFRRHTGVKPYTLKECGFVCRRRSDFHERIRRHTGEKPYMIKVYEMWHYLSSDKREDIHVCVTYVLLRFLENYKHIKEVIHKRSRKSVTNELLLYFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G902</accession>
    <name>A0ABY7G902_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TCB2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF129">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="27"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="208" mass="24406" checksum="F97A9EF07CFBDA2B" modified="2025-10-08" version="1" fragment="single">MTQRHSAARLLWARRHLIWRRADWNRVLFTDDSRFTVMLMEDYGFADCCIVEKNRFGGESVMVWGGIMGNRKTDLVFVQGNIDAQRYVADVLNAYALPFIRQHGPGETLMHDNARPHVARATTQFLQQNNVNVMPWPAVSPDLNPIEHIWDQLGRKARAYHQIDNVRDLTRALQQKWRNLPNALVLRYVTSMRRRIIACIKCKWWPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9P0</accession>
    <name>A0ABY7G9P0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FXR2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_013660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd22427">
        <property type="entry name" value="KH_I_FMR1_FXR_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040148">
        <property type="entry name" value="FMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603">
        <property type="entry name" value="FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603:SF7">
        <property type="entry name" value="FRAGILE X MESSENGER RIBONUCLEOPROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR27956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="370" mass="40329" checksum="2DA3F6CFB666107F" modified="2025-10-08" version="1" fragment="single">LAKVIGKNGKNIQDIVDKSGVVRVKIEGDNERDAPREEGQVPFIFVGTVENISNAQILLEYNLDHLREVERLRQEKLEIDQQLRTLAGPQSGPYYPNPRDRRGDSMDPYSSDRDSDRRGGFRGGRGRGRGRGYPRRYQDRYGDDNEHYGGAVGDWNREVMQEERRQQGYLTDSVLSSRGRGDYDNRFSRYPPRDRDGFRPTSYDTDDRDERVDRSRRRVADDDDTVLDNASVTSQDQETDTSVSNFPPPSRGGKPGSGRGGSTGNRPEGKSGSPAPVGNAASGSRPSNGGESQAVSGEGTGSGVAKGASGSSSGPAPRDQRERRTMGNRQPAKNGYPPRGAHSGNEGDNRGGKGAQTGSIGKQEQVVNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAC5</accession>
    <name>A0ABY7GAC5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="91" mass="9877" checksum="801E6543D8FCE09E" modified="2025-10-08" version="1">MVSGQTGVNGLHVTSHAIKENTHAQEHVPTRNQRITAVTVSALPMNINVVTANHVLMASGLHGNNGRHVRSRVGLVLHHVTENATIPRHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAT2</accession>
    <name>A0ABY7GAT2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="906"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="925"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="944"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1112" mass="124402" checksum="14221FFE4BF7A3D4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GC29</accession>
    <name>A0ABY7GC29_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNPC4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_034495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="265"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="317"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="372"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="618"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR31953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="712" mass="82810" checksum="C480A2578633834C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GCH0</accession>
    <name>A0ABY7GCH0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HES1B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_033328</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="15"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR30786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="255" mass="28427" checksum="5541562AEDA3F897" modified="2025-10-08" version="1">MADMRDSPREVSSYLRKVRKPQLERKRRERMNASIDRLKLLIADTIRQQMAPMTRVDKADVLELTVFHLTRLQQHQRAARVASEATAASYNAGFRDCARETVTLLGATNATDTSLTTSVSDHLHGVYVEKTKSAEENRLLETKFQASSSQAYPAQDQHMFMSTPRRADDRMDGDVEIPEFSPISRLLEGQCAVSIHHSSSSGSSFRSDESGFSSLSVSSGAQSHDSIASDGEISIGQNTEDKIGHVIKDNVWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GDG3</accession>
    <name>A0ABY7GDG3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_033548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098">
        <property type="entry name" value="AGAP001331-PA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098:SF16">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR31006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="288" mass="32735" checksum="FA0EF4753FC8480F" modified="2025-10-08" version="1">MSLEKQRTTWDEKERLCAVRLVIEQYDVLYGGFADGITFKEKSAAWNKVADDLNASSNVKRTPAEVKKLFQNVKSRAKKKYNENMATGGGPVGKITLAEEIVLEFLKDKPQLIGIPGGIESGVIEPVEDAASVADLVVQQAPMTESKHISTHQETMSVHAIEHPSVSHEHPDEPRVMQTNTKKRRRKCMDRIELTEELHDLEVCRARKEIELLDLKIAQQRLKLSCKDNRYGMNCLADSRPGHAMSLCNYDVMRSGCKKLKAAQYRQERGERVAPHRRCTDRWLHDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GDT8</accession>
    <name>A0ABY7GDT8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MIGA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_033668</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitoguardin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019392">
        <property type="entry name" value="Miga"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21508">
        <property type="entry name" value="MITOGUARDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21508:SF5">
        <property type="entry name" value="MITOGUARDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10265">
        <property type="entry name" value="Miga"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR31126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="349" mass="39482" checksum="D0F3F5A30C8EDCBA" modified="2025-10-08" version="1">MSYRSRSPSSLRSLLRQKSLSGSTASLGAASTSTTSTIIHPGAQDTTDMSPEHLCLETLRIAVSYWEDADPSTASLQHRLEHLLELAYHMQDSYEREVVRATDHMMFDTAINAFTETESLARSRTVSRCSSSDSFVSATDLADLSDLERHQDMFHHLALYEAGVLELKHGSVSCRTLRLAMQEIFRVQEHRDYFTEMGRQVISSLLLQAEKDADDFHTAFNTMMAFINNADNWSKMEEELRGRGALSTAVWSVLKAKRRMLKFPDGFIGHFYNVSESVSPVLAWGFLGPESKLKDICFYFKEVVLGFIQDMFSFEKARYTTVDDLASDIVRLAKTRIDQVLQKLNADPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DEW7</accession>
    <name>A0ABY7DEW7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FMAR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_028882</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="51"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ96192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="393" mass="44867" checksum="C71DD7BE12515F4A" modified="2025-10-08" version="1">MNHSDMANGTEVLAFDTGHILSHEVMLTARQMHHITSAYIGPVFLVLGLFGNLLSIVIWRKKLMKSSTGTYLIAQAVNDIGVLIFFFLTDSLIELAPWVKMSNIFGVVYAYIGYPMFYFFVVNSIWTLVGVTIDRYVQVCWIDQAKILYIFPLQTLCNERAAQIGVALISVLSFIINMPHFNTYRAVPNYERDANETAYEYTEFGHGAGSQLYEFWIHCMFLVLAPWVSIMFMNMAIIFRVGQLNKKMLQMRGNKAQKRAQRKENQMTNILLTVTFTFLGLIALQCVTQCFFMMQPENMNFEMVNEAYSVAKLGIVINSSINFILYCVTGKRFRNELRLMLFRLTHIKALVPLPGTNDLYNSQDPDLLSSSPTISKDRKCSMSTVEKDADSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DF08</accession>
    <name>A0ABY7DF08_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CALL5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_007485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ95014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="236" mass="27188" checksum="AFEA27C651586E6E" modified="2025-10-08" version="1">MADSPQTPPSPNKSDESPKSSIQVVTSKSAGSDDRKIEVKVSPLGDKNVSIEIKKGQGENEDKQDENDPIQVKPITDEEVEEIVSKYKSIDEKDLKKYLDFFWSVDEYKFGAFTVHQLAYRLGCSGHRLTNQQIARMFSDLDQDNDMLVSLDEFLTDMAKPKRQTLSKSELKVWFDRFDTDHDGYVTRKDIMETVESLGAYMLTPHLDEFMKHDRSGNMERLDFEEFCFAYKMSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGT6</accession>
    <name>A0ABY7DGT6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_029209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ96519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="103" mass="11708" checksum="2EFBA963A26163E9" modified="2025-10-08" version="1">MKRTSVMIKKEETKADTQDSLLSVIDASLCDGKRSFAFWFVRAGMKSQCYPTIPVMERYLSYILHILVSPLPFLRLSLVVEAWARMWPPIGFFGSTANLGMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DH30</accession>
    <name>A0ABY7DH30_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_028971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045661939" evidence="2">
        <location>
            <begin position="26"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ96281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="231" mass="26502" checksum="F44B7B9816A11771" modified="2025-10-08" version="1">MKQSNMTVLCITVLVLLYFQGVCYGYYSTNGGNVSLSDVTNRFFVHLRPDDLDLVQDELKTHSLTYHSKVVDNLHIFENKSNTIYRATYLELDRLKANIKGKIRQIEQCRRLLVENDKGNNTAKKDTRMKSLAPKFRMAQNIANPNAMDEAHSLLVCPPYWDNQEGIDEVWNSSVTGHGVLIAVTDIGMDVHHPELHPNIEMSLRWNIVNNNTDVSPEHFPNYYESFVTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHQ0</accession>
    <name>A0ABY7DHQ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MARF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_029196</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd08824">
        <property type="entry name" value="LOTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024768">
        <property type="entry name" value="Marf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045602">
        <property type="entry name" value="MARF1_LOTUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034189">
        <property type="entry name" value="MARF1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14379">
        <property type="entry name" value="LIMKAIN B LKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14379:SF3">
        <property type="entry name" value="MEIOSIS REGULATOR AND MRNA STABILITY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19687">
        <property type="entry name" value="MARF1_LOTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11608">
        <property type="entry name" value="RRM_MARF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MARF1 RNA recognition motif 1" evidence="2">
        <location>
            <begin position="226"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="MARF1 first and second LOTUS" evidence="4">
        <location>
            <begin position="626"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="HTH OST-type" evidence="3">
        <location>
            <begin position="832"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="HTH OST-type" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="domain" description="HTH OST-type" evidence="3">
        <location>
            <begin position="1193"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1441"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1559"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1730"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1275"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1300"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1441"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1730"/>
            <end position="1770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ96506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1786" mass="199449" checksum="B121A1CE9CF81105" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIX0</accession>
    <name>A0ABY7DIX0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ZASP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_030326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF38">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="237"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="297"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ97636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="352" mass="38032" checksum="A6C6161C77D0CDF9" modified="2025-10-08" version="1">MELSPSSALFIEELCPLATNGQQQGEEVQYDAQGKRLYRPSETFKLVREQEHPEENSTDEKPQEVKQTRTIKVLEKQLGEGSAPAPAPAKAPAKAPPAPKPGVWAPGQGAPAAPPAPPAKAFNPSAAPPFTPAAAPPASRPQAPKAPPSKPTGVGAMRGKIGDAVVKTGADAGRVPICHSCGGPIRGPFVTAMGKSWCPDHFICANPRCGNKLMNMGFVEEGGFIYCEKDYELYFAPHCAKCDAAIVGECVNALNKQYHPACFLCFKCKQPIGGTQFHLEDGHPYCENDWRQMYQTMCTSCNFPIEPGDKWVEAMNNNYHSECFNCSTCQVNLEGQAFYAKSGKPYCKKHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJ65</accession>
    <name>A0ABY7DJ65_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GDE1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_014681</name>
        <name evidence="5" type="ORF">MAR_030064</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd03716">
        <property type="entry name" value="SOCS_ASB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="276"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ97374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR20707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="333" mass="37725" checksum="9047ED82950ED7F4" modified="2025-10-08" version="1">MSVQSEMCQAPTAQDIGCVEKVVISRNMGEPYRSKLIPTTSFKPVNDYNLSQLAFDLYMAVISGYQEAVRNILMSHPDVDVNISVKGATVLSLSLQKRQFHIFSMLIKHQERSKKFDLNKCSKDSFNRVEPPVITACRMHFFEGVVALINNGADIDATDHLGHTALWVAARQQMPDLVEYLIVNGASVNKTDVYHHTPLITAMMYRVSSGIIKMLIMNGSSLEGPRYPANTQLSPLFWSLKYKTLEILKLLIHVGVSNSEIRYVRKILYARNGDPQLIELLDIEAKTPRTLKQICRREIRKHISDVCLGKTFIHKLKDLPIPTVLKQYLALKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJC3</accession>
    <name>A0ABY7DJC3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GHITM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_029487</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ96797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="234" mass="24786" checksum="C5200E9E6B3FFA1F" modified="2025-10-08" version="1">MFSVRISTIPMSAFVSNLASKPQALKAVALRTHNVMRVQKYAQQAGSRFTRRQATKETTKQTWKEKAMAPAGTGAFSAGRGLVAAASGIGLAAFGFYGLGLSNEPGVIENSRLWPDFVKERVRSTYMYFAGGLGVTAATAVAVSKNAALMNIMTKNSLLAIGATFAVMIGTNMVTHSIPYKKGFGAKQLAWLTHAAVLGAIVAPITFLGGPVLLRAAWMTAGVVGVLLEYMLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKM5</accession>
    <name>A0ABY7DKM5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF4">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="65910" checksum="85454C3B898FEBE0" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DM79</accession>
    <name>A0ABY7DM79_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CP135-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_022361</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CEP135/TSGA10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd22292">
        <property type="entry name" value="cc_Cep135_MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051877">
        <property type="entry name" value="Centriole_BasalBody_StrucProt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20544">
        <property type="entry name" value="CENTROSOMAL PROTEIN CEP135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20544:SF0">
        <property type="entry name" value="NUCLEOPROTEIN TPR_MLP1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="463"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1164"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="72"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="187"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="549"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1130"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1173"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1204"/>
            <end position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ97988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1214" mass="140123" checksum="0042E59A4371CA76" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNB2</accession>
    <name>A0ABY7DNB2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SMCA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_023217</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="88"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="250"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="9">
        <location>
            <begin position="616"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="761"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="585"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAQ98844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="780" mass="90867" checksum="8BA081B80F457596" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQA4</accession>
    <name>A0ABY7DQA4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ANMK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605:SF0">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="381" mass="41948" checksum="2F0593B0157686E9" modified="2025-10-08" version="1">MASFVGVGCMSGSSMDGLDICCVEFTGDIFTDLWGYRILAAETVAYSKQWSERLRDADNLSGIELIRLHVDYGRFQGKCVSTFITKHRLNERVQFVASHGHTVFHKPQEGISFQLGDGEVTAAMLKVPFVCNFRAKDVTIGGQGAPLVPCGEKYLFRNSDICINLGGIANIGIKGMRGYDICPCNRILNSLVLEKGGGQQYDKDGDLARSGDMVPEVLVKLQNLSYYQQDPPKSLWVDYIEENVLPILDCNKYKVENLLRTCTEHVASMVADACFEAKPSIATTSHHPNRTVLITGGGALNKYLVELIGQYLDAQGFEIEQVDEETINFKEALIFAFLGMRCLLGEDNVFSETTGARQDSVSGSIHRPLSSGSAKHISLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRF5</accession>
    <name>A0ABY7DRF5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF2KT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_030225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029426">
        <property type="entry name" value="FAM86_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14904">
        <property type="entry name" value="FAM86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAM86 N-terminal" evidence="3">
        <location>
            <begin position="73"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ97535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="418" mass="47125" checksum="EFCB73419920529D" modified="2025-10-08" version="1">MATSRQNPRQIDGREETMFSSIASQFFQMVPIRRIQWQLLMFCDREPVTIDKSITLSFLSADVQKEELGVDQQRILLSLTVRSQLCQSYPPSTQYQRVFVKKLLSLLEEYDVEICDDLYEVYTDLLQQHDTEEDALCYKTFSLGEEESVTVVESVNMISFGTTGLSTWQACGVSSYAFTDNSSHVLNLVAHNVHQNLSRHISGPYTSHNRIKSGQSGPVKQVRHSSEDDVHHVSACGGETDHTECDRTRQGCRNNSDVDGVDDCENMSTSVTSISDLQDGDDGALNLNRKYWKEIGHDIFAYDATRTVSVGKLDWEATRDQLEEPYRDIDMVLAADVVYDVRVIPALVHVLKTFLTPSDGRSPCVAYIASTIRNEDTRDQFLIALSAEGLCYTPCESPSRQLFHYDNSVPIEIIKVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DS46</accession>
    <name>A0ABY7DS46_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FBN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_024902</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.290.10">
        <property type="entry name" value="TGF-beta binding (TB) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051145">
        <property type="entry name" value="GAS-SHBG-PROS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017878">
        <property type="entry name" value="TB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036773">
        <property type="entry name" value="TB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24040:SF16">
        <property type="entry name" value="FIBRILLIN-2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24040">
        <property type="entry name" value="LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00683">
        <property type="entry name" value="TB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57581">
        <property type="entry name" value="TB module/8-cys domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51364">
        <property type="entry name" value="TB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="TB" evidence="9">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR00530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="238" mass="25192" checksum="0FF5247FFD61CB02" modified="2025-10-08" version="1">MDLHCGHMDDCGLRRATFPAIPGGRTAKCSGNCGGAGNCMRPGLCLCFTGELASYCGSSGGGGSLLSLCEPACQNGGVCVARNLCRCPSGFSGGSCENDQRTGPCYTNLENNMCRGQIPNVVCTKHLCCATEGMAWGDPCEACPANPHPCRRGYVLNLAKNTCQDIDECKYIPGLCVERHLCEENYCFQRVVNGKCTSGLPPRHLCLMLLWGGEGLGIRRLVSALSAQNTGECSNSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DS51</accession>
    <name>A0ABY7DS51_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_024306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd10229">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ99933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="680" mass="77110" checksum="88A24F0498D575AF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTD0</accession>
    <name>A0ABY7DTD0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AOSL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_022583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31718:SF60">
        <property type="entry name" value="LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31718">
        <property type="entry name" value="PLAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="2">
        <location>
            <begin position="10"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ98210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="162" mass="19477" checksum="FAA77E7F6775C62E" modified="2025-10-08" version="1">MENGMTSETTDYVVLVRTGDRKRAGTDANIRIIFHDNQGKKTDKIRLHHVFKNDFECGNIDEFVIQKQANLTTVDKVELWRDNFGFGSRWYCDYIIIRKKDSDTEYSFPVFRWIKADVHYIFRLNDTMLPQQDPMAEQRWKELQKKKKKYHPSQFKLNIYMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTG2</accession>
    <name>A0ABY7DTG2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="62" mass="6890" checksum="564BB0FB3FF4261F" modified="2025-10-08" version="1">MAVFSKGIALAGENLKSRRSRSPVRSRSVSPGPRSRSRSRSVSPTRRSRSPSPRRAVWLKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTG8</accession>
    <name>A0ABY7DTG8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_024279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ99906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="120" mass="13012" checksum="D831DB49AA646330" modified="2025-10-08" version="1">MREREREREREREGEGEGEGEREGGGEGGRERECCFVEKILDRSDSEYNPSSLFAASDSPLAINSLEIGPDPIVVPGELQISLSGSSSVVIGNSSLSLSIKRDTWLGEIGIPCISNIGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTM6</accession>
    <name>A0ABY7DTM6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR01072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="164" mass="18412" checksum="BF96911CF686080C" modified="2025-10-08" version="1">MCGRRSYDTVCSRRSFATVCVRRPYDTLCVVEGRMTLCVEGSGRMTLCVVGGLMTLCCRRSYATVCGRRSYDTVCCRRSHDTVCGRRSYDTVCGSRWYDTVCWLRSYDTEVARNCVVGGRMALCAEGSRMTLCVVGGRMTLCVVGGRMTLCGRRSYDILWKEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUG4</accession>
    <name>A0ABY7DUG4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">GLRA3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_024678</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="146"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR00306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="311" mass="35807" checksum="E681DDA0D1B3F89D" modified="2025-10-08" version="1" fragment="single">EFSIGTFLRQTWNDSRLSYNALPNLKALELDTRMMEKVWVPDLFIVNEKEASVHMVTVPNRLMHVFPSGKVHYNGYSTDNLVFEWNPIPLEIDRSLSLAQFDLGEIETRRCDKSYIGDTDGNIVNYTCILMQFELIRNFGYYITQIYIPSILIVILSWVSFWLDIDAVPARISLGLLTVLTMTTQSAGARSSLPKVSYIKGIDVWMAVCMVFVFIALIEFAFVNVNTRVGKRRDTKTKKETTSLVKKDGELKNDTPNDGRLNRWNVFVSSRNNARIMDRFSRVAFPVAFIVFNIVYWSVYTFWQPSKSDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYK1</accession>
    <name>A0ABY7DYK1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="166" mass="18988" checksum="25CF9D05D5B21329" modified="2025-10-08" version="1">MYYMWKLCVYNQAFHSVSDIKAKCYLWSELNGKRGSNEISTCLQLYLSTLPSSVNLVILYSDDCPCQNRNQIVATCLLDAANTIQTIHTIDYKFLESGHTHMESDSAIEFAKSKTDLCTKRVGNHSSNDKTKNTYETIKESKQKLRRQKVAKKQMELNEVDEVSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZB6</accession>
    <name>A0ABY7DZB6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GABR2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_008164</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF74">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="11">
        <location>
            <begin position="374"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR01606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="618" mass="70140" checksum="8802299543FAFAD6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0H3</accession>
    <name>A0ABY7E0H3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fucosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_008895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">Golgi stack membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="8">
        <location>
            <begin position="54"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR02337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="176" mass="20526" checksum="50E342AC7C87F93C" modified="2025-10-08" version="1">MVGSLSGKNMAHHVQGADLFLPHESRAGALVMKGTTDIQSEKRPWLWTGNDGYHHLRHDVIPIVMGAAPEDYRRAAPHYSFIHVDEYPNPRALADYLHQLDANDNAYNEYFRWKGTGEFVNTYFWCRLCAMLHDDTRQMTTYDDVNKWWRGKDVCIGKDRWGEHADRGRYISDFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E210</accession>
    <name>A0ABY7E210_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_009416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF18">
        <property type="entry name" value="SHORT-CHAIN COLLAGEN C4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR02858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="145" mass="15928" checksum="3A4604D9F2A52D61" modified="2025-10-08" version="1">MNDEEVPCVVCITPNTNVVMVPAKNVCHPGWTLEYAGYLMAERSTNNAKNYVCMDGVPDNLDKSRGDQGGALFYFVEASCGSLPCDPYIQGYVLTCAVCSLPPSICPCFNSSYVSQVNEGHFRDSIMESTKQIVKVFVKAYLAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2T0</accession>
    <name>A0ABY7E2T0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_008024</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF116">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045583540" description="C1q domain-containing protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="6">
        <location>
            <begin position="105"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR01466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="223" mass="25397" checksum="B06B7E11700A3466" modified="2025-10-08" version="1">MLTSVLLLVVLTCVFAQETCDKRLSTLEDKISVLLDARENDRKEIKELRQKVNDISRHVSMVTENDPKIHKRQGYIYNQKLADDYSYELGYIYNQKLADDYSYELAIYAPAFTACISPRDLTNIHQHQTIIFDHVITNYGSAYSTSTGIFTAPTPGIYIFFLEIMVTSHYEIDSALWVLHLNRGSEVLIRSSTSYIEGHVGQIHGYCHSSLSGFLLNELENSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E358</accession>
    <name>A0ABY7E358_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="123" mass="14178" checksum="FCEE62CB8FE6BD9E" modified="2025-10-08" version="1">MDTILATCHKYIRESSCICFYIRFVPRFAAAICRYLTHIAMRGLLLKLPVFDQDQLGEVDDLYEDAVLWNLPEEEEHEHAKKYIEDKNGSQMSEMPRVTEEKGSCKEVGKGDTLQYTKVNVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3T8</accession>
    <name>A0ABY7E3T8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MNX1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_019884</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042768">
        <property type="entry name" value="MNX1/Ceh-12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24335:SF4">
        <property type="entry name" value="EXTRA-EXTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24335">
        <property type="entry name" value="MOTOR NEURON AND PANCREAS HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="205"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="207"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR04515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="331" mass="36740" checksum="D3C4D9244B5C0CB4" modified="2025-10-08" version="1">MKGAFSIDSLLAKKTDTRHPSPPPTSSPLISPHTVTSSNGSSNPSTPSPEMRLSPETVQHKHHMLKNGLIPRPGLLSPHQQMLLQSNPLALQGLLQAQYLNALNGHAHQSAHTHGGHGTHGTHGIHGHPAQHQHGGHSIPPSHLPNSSAFHSPGEHAFKMAAHLHGGHGQSPHVPSYLNDWMSRGGMLMSRMMDYTAQAQNSLMGKTRRPRTAFTSQQLLELERQFKMNKYLSRPKRFEVATTLMLTETQVKIWFQNRRMKWKRSKKSFPTNQKPADNQSDPSVAQDDAGLDLSETEMADMENDSDIDISDDQDVDIERSDDNIEHVNEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E490</accession>
    <name>A0ABY7E490_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039471">
        <property type="entry name" value="CXorf65-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33887:SF6">
        <property type="entry name" value="CIDE-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33887">
        <property type="entry name" value="PB1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15874">
        <property type="entry name" value="Il2rg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR03760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="82" mass="9208" checksum="C704EA9F342C4EEB" modified="2025-10-08" version="1">MTGSEGEKSFIIVKYGVTIDLVDLDGQVTNLSGRAKDYAHELVTPRGIYILIRVDRLPDNGQFHYTSLLNNLEETNPELMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4C2</accession>
    <name>A0ABY7E4C2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="149" mass="16881" checksum="D4EA4CFB7001C1BF" modified="2025-10-08" version="1">MRTDMGREGMDGGWAWVVLAAVLCSQILLGGICFSAGIFYFIFEREFDSNPVELSWLCSLPTTMWLISSVLYNLTGTYSSSFYLAGASSVIASLLMIHPIVCRRRNTMQKKRGLSEIIAEQEVFQVERKQTFLCDDKYTPSYKEDNADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4T6</accession>
    <name>A0ABY7E4T6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MYD88-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017281">
        <property type="entry name" value="Myelin_different_resp_MyD88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15079">
        <property type="entry name" value="MYD88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15079:SF3">
        <property type="entry name" value="MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="350" mass="39360" checksum="45429629CF5ACDAF" modified="2025-10-08" version="1">MDVQNPEQEIELPYDYRMLPLRALRMTARKKLAGFLDLEGTVVLINEGAMDEADVRNDSPTTKRVVILMSKQFLRSAVCDFQVRFAHALAPGARSRKLIPLIRERGTVIPRILRFLAVCDFTKQDMLDWVWDRLYAAIIAPIGKQTYFEPDDEENPFREESLKEITFPTFSPLDGPANSGNTDRKQSYLSEHSTPSMKAKSAASTPVMQPHALNNLDIGESYSVSPSFRQNNFNSAQTAIISKTDNTNAHNVTQNSYPSNSSNASAKNKKHKKVHPVSPLPRTSREPIEHPHHSGAKSDSHVISSTNPTASFGTRQRSNYRREVDETSYQSSRNNSQTISSTDGYFEIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4Z9</accession>
    <name>A0ABY7E4Z9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NR1H4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_010436</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd06916">
        <property type="entry name" value="NR_DBD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="9">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR03878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="450" mass="52068" checksum="775F214D644DF90A" modified="2025-10-08" version="1">MNDGIAEVRECMEGGSDAERKPLLPPCRICRGKASGFHYGVNSCEACKGFFRRCLRTKNELKCAADNDCTFRRGSRTNCSACRFRLCEQQGMSKQAIKTGRYTSARRSQYIKEVKLEAHTPGSTGINEEENSPSTADPIRNALECQDVPRVLHYDSLVSDLLQAVSRTIEGDLDSFLNKLKMESRKNDYFIFDFFSESDSILEYWLLSHFQCMDDDLKVFTGKFNTSYRDSVAIYSDEYLECLYRTAALFKNLKLTKEEIVVLKTIVLTFTDRCELRDRERVEKIQLQMIDCYKYICQLQGLHFNKRFATVISKLLQARILSEKFKDIVKTVVSHWEAVFDEWPKETIRTYSTHGRDLYCVFVDIHNEAWIWKPLIINHTGKMCDTYMRHVIAHTSQNWRVAFAVFEAEAAQRSGTNQHSIDNRSLWKLGFSRCLFLQSADLSPLVIPMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E509</accession>
    <name>A0ABY7E509_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_019643</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047430423" description="Ig-like domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="134"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="252"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="498"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR04274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="530" mass="59120" checksum="25FAC4B76DF8C853" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E571</accession>
    <name>A0ABY7E571_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LIMD2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_010249</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd09358">
        <property type="entry name" value="LIM_Mical_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24206">
        <property type="entry name" value="OS06G0237300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="789"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="654"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="750"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="764"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR03691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="874" mass="96997" checksum="CB2E6DFEF735F37E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5K0</accession>
    <name>A0ABY7E5K0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="137" mass="15148" checksum="F395DCE27C56B205" modified="2025-10-08" version="1">MTEVDKFLFNLEQLVRDAIKDNVAFSVGPSEKSNKKTIDVTKQRNDLQLEPGHKSSDQISGNDKPVVDIFKECIADTFKILSAEVSHLNHQCQDTVKNKLLPQFNSLCDADQRASNSHNGPFGTASVTIDGSSWTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5Y3</accession>
    <name>A0ABY7E5Y3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTPase Era, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ERA-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_010387</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd22534">
        <property type="entry name" value="KH-II_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTPase_Era-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="GTPASE ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698:SF1">
        <property type="entry name" value="GTPASE ERA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="7">
        <location>
            <begin position="59"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR03829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="560" mass="62783" checksum="A95A75D813F909AB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6U6</accession>
    <name>A0ABY7E6U6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YPF05-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047469984" evidence="1">
        <location>
            <begin position="19"/>
            <end position="1608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1608" mass="160379" checksum="9330668FFF699C6C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9F5</accession>
    <name>A0ABY7E9F5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="89" mass="9736" checksum="DABCDDA9ED7246AF" modified="2025-10-08" version="1">MSSSRNSDVPRRKEHVYEGTDTDNRIDTHSADDPGLNTTQTYEALSMTMDTVAYDELKIGVNGANHLDVLNASSAKPLPYYGNVQTGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9Y8</accession>
    <name>A0ABY7E9Y8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NK-tumor recognition protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_021353</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052445">
        <property type="entry name" value="ZnF-G_patch_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17614:SF14">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 8-LIKE ISOFORM X5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17614">
        <property type="entry name" value="ZINC FINGER-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1066"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="587"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="613"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="663"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="699"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="713"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="743"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="758"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="783"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="799"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="824"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="884"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="901"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="918"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="982"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1004"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1066"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1089"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR05984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1281" mass="143632" checksum="375BFE00CEE5934C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBP4</accession>
    <name>A0ABY7EBP4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="48" mass="5776" checksum="D7D5C755D4EED4E8" modified="2025-10-08" version="1">MSIIVERQQVEMVMGRKKQRKRHLHWRLLPCVRSLSTMPGIQSSLFPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECP5</accession>
    <name>A0ABY7ECP5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128:SF1">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="872" mass="96084" checksum="29D581E859C641EF" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EE61</accession>
    <name>A0ABY7EE61_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_018251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="5">
        <location>
            <begin position="66"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="4">
        <location>
            <begin position="203"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR08293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="294" mass="34211" checksum="624FB03C5A54D269" modified="2025-10-08" version="1">MSVINYSKWDHIEHLPPIACIMRIFLIPPPAPSRAASPPIPPADCPAIGFCQMCKNIVKIMFQTQISDDEDDTHPNIDTPSLFRWRHQARVERMEEQKKEKETFKSELTSHQQKIHDMKQKLKEAEEKKALEDLDALKKELKEMEQQETEFRRKEDEIKQAQKEYMDAFNDELNGFKERIRTRAKQKIEEAIKEHEEEERQKRLGPGGLDPVEVFESLPDVMKDCFEKKDIEMLKKVVVEMPKEDAEYHIKRCVDSGLWVPGGAEGEGEEGAEEEGAEEEGEGKEKDEIYEEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEI0</accession>
    <name>A0ABY7EEI0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MIO-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="1">
        <location>
            <begin position="37"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="131" mass="14891" checksum="9F7E403D3044EE51" modified="2025-10-08" version="1" fragment="single">YRDLLNRWKLWHQRAKFDIIRHAVDKSRVPGQAFVSCNYCGKSIACNMTLASRPRASHYNPPPNNRPKSTICPGCRKPLPRCALCLTNLGTLAGSNLYMQKDKTDWFREHAECPVTGCLCHCMTLDPNSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGK5</accession>
    <name>A0ABY7EGK5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G2E3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_017751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="4">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR07793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="610" mass="68486" checksum="2B347AFA64E48EF9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHM7</accession>
    <name>A0ABY7EHM7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATG11-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033438">
        <property type="entry name" value="MOLO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748:SF5">
        <property type="entry name" value="GROUND-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748">
        <property type="entry name" value="PROTEIN CBG04600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17175">
        <property type="entry name" value="MOLO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="401" mass="44764" checksum="F91E2CBB49BE2684" modified="2025-10-08" version="1" fragment="single">SVEKERCRRVNQTVNQTVNRTVNQTVDQTVNRTVNRKTTKQSTEQSTKQSTEQSPKQSTKQSTEQSTEKSTKQSAKQSTEQSTKQSTEQSIKQSTQQSTKQSAKQSTEQSTKQSTEQSTEQSAKQSTEQSTKQSAKQSTEQSTKQSAKQSIEQSTKQSTEQSAEQSTKQSTEQIGGAPLKFIMKALLLLLALVSLGGCVLVEWTADEFFNPLEEPEKCGRHESSPSYVCDPNGIITVRQADFLDHILLNMQNETDCPCSTNNCESRAHSKGYIIAIALVKKLKRPDNVPDNEMGRMGLAQTFVYDLQRKHWLMTTTGVTPARKLTGEVTNYIQKELVRFFQKGGNVGQGLHYLTINYRHVLDNYKYSPVLYADTPIHSTAAMATISIATSIITTLLAIYFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMG8</accession>
    <name>A0ABY7EMG8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14882" checksum="A95A249C779E3163" modified="2025-10-08" version="1">MSFKYFLFVSPLISIKRMYKQLNRVYRGLFPTVDEYKASTGLPILGEACNATESGDPKKREGCSHSGQGDKDECCETNGPHTKRCKYCQQQKSVTYLFAYNYKTNKFGFFPFEIPTYCSCKSSDCKQNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMU9</accession>
    <name>A0ABY7EMU9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FGFR3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein kinase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="116" mass="13730" checksum="94B26B63DA2086A4" modified="2025-10-08" version="1">MFQERIPIKWMAPECLKTTKGASEKSDAWSYGVVLWEIFSLGDAPYENMRGKEIPKKLKSGYRLPKPEKSDDKWYGVMTRCWEANPDQRPTFKTIRGELDEMFVAAPQDDYYYYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMZ4</accession>
    <name>A0ABY7EMZ4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="175" mass="20654" checksum="E177BCABADF5F1C1" modified="2025-10-08" version="1" fragment="single">MLGSPNMYQTMFINICWVHHTCIKPCLSIYAGFTTHVSNHVYQYMLGSPHIWVHHTCIKPYLSKYAGFTKHVLNHVYQYMLGSPHMYQTIFINICWVHHTCIKPSLSIYAGFTTHVSNHIYQYMLGSPHMYQTIFINIYWVHHTLCYFLESAVHLRLNMEVELKQTKEALAQVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EN00</accession>
    <name>A0ABY7EN00_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein quiver</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_025538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047312804" description="Protein quiver" evidence="3">
        <location>
            <begin position="20"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR11358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="13792" checksum="0F3B5470CBC1EFD4" modified="2025-10-08" version="1">MSNLKHLLYVILGCIVVSSSDTVGSDTCYTCVNCKDTQIDKMHTVRCSGSCFKMHGKNDDGHENVNRGCLTLFEGMAFGAESATCLAGKVGKYYGEICICNGDKCNTGSSLVGSISLIMSVIAMCLHMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EN39</accession>
    <name>A0ABY7EN39_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BUCC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="599" mass="66265" checksum="1260462402F8BA48" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ER08</accession>
    <name>A0ABY7ER08_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TEuncharacterized</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="934"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1381"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="860"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="935"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1391"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1426" mass="158394" checksum="3BC5598EBCC8F060" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERB3</accession>
    <name>A0ABY7ERB3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AOXB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde oxidase/xanthine dehydrogenase first molybdopterin binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="100" mass="10647" checksum="DA209415AD7310A4" modified="2025-10-08" version="1" fragment="single">VGVSNDGILEAIDVKLYSNAGYAVDLSWPILENAVTSFESGYKVRALRVVGRACKTHTASNTAFRGFGHPQGVLVMEDIVTRAAAVTGLTPEVVSYRTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EW38</accession>
    <name>A0ABY7EW38_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CP2U1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_027302</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF1">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR13122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="110" mass="11924" checksum="F176774A8AF73779" modified="2025-10-08" version="1" fragment="single">MKTVVVNKIDEALEVLVKKSTDFANRLIVPSVEMFTDGGRDIVFSNYSPMETTPETLLKGPQGPALEHRVHAALETALAEMDGHADSPFDPVEHINFIVGNILTGLCFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EW77</accession>
    <name>A0ABY7EW77_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="87" mass="9163" checksum="97EB7FB0A3EFCCC9" modified="2025-10-08" version="1">MAHTSSLIIPPNGSHIIPPYDSHIIPPNDSHIILSNGSHIIPPNGSHIITPNGSHIIPPNGSHIIPSNGSHIITPNGSHIIPPMDHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWJ6</accession>
    <name>A0ABY7EWJ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="203" mass="23262" checksum="1E118643FB3A0505" modified="2025-10-08" version="1">MRESAMNAGMNVNNIRLVTEPEAASMYIRDMCIQTKGNKNITPLEPGAKYFLVDIGAGTVDLCVHEVLKKGNLMELYPAAGAHFGGSNVNFQFEELLKELFGNECIQMMKRNKMFKYFNLLQEFEDKKRQFDPSAKDVVLSVEFVVQEFEEHSTESMNERISSGKFHNKLKYEKDTGNAVTLVYRWKTLALLTPEVTFRLRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWY4</accession>
    <name>A0ABY7EWY4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoenolpyruvate carboxykinase (GTP)</fullName>
            <ecNumber evidence="3">4.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_027114</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="3"/>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003253">
        <property type="entry name" value="PRK04210.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal" evidence="11">
        <location>
            <begin position="157"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase C-terminal P-loop" evidence="10">
        <location>
            <begin position="249"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR12934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="616" mass="69224" checksum="AD9929AD0C984162" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZU8</accession>
    <name>A0ABY7EZU8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SC6A9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_004995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR14890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="71" mass="8391" checksum="8C5A27F3B1AB8AA7" modified="2025-10-08" version="1">MNTRGNWKNYREFLFSCIGCLVGLGNIWRFPYICFRNGGVFALVFVTHFCDLQFGIYGKSVYNIFTYRLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0D9</accession>
    <name>A0ABY7F0D9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF1">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="770" mass="86345" checksum="D081F888175B620D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0Q0</accession>
    <name>A0ABY7F0Q0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YTX2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="147" mass="17107" checksum="CFF397AFE61F7779" modified="2025-10-08" version="1">MYIAHRIGTLNVYGIRNKIEREKIFHSLKRKSYDIEYLQETHCANESEAFLWAKSWEGNITWNNGSTQSRVVAIFIKNIDLQLQVVENSLYNDEHGRIISLRANLSERSYYQYTDVYTPNAGIDRKWVILTVLLIKASIGKGPQLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F194</accession>
    <name>A0ABY7F194_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052825">
        <property type="entry name" value="CCD-Prefoldin_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031476">
        <property type="entry name" value="DUF4686"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34479">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34479:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15742">
        <property type="entry name" value="DUF4686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="600"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="653"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR14646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1069" mass="124954" checksum="C3738DDC207CAA8E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3F7</accession>
    <name>A0ABY7F3F7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GSXL9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_030751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR16157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="373" mass="43276" checksum="A43C6DC73DEE5136" modified="2025-10-08" version="1" fragment="single">MFIIACTDECGNPCFNAVFIIPGTDKYGEPCFNAMYKRLQINSPKEVLEFPDYSYREHFGRRVPSYLYRGEMLDYMEGRWTDNSRCDLRQFIRFGTAVRHVAFDDESGNFKVTVNDLEKGSYHEETFTHVIVAVGLYNHPCLPEFPGIDSFEGRVLHARDFRDDFEFRNQKVLVIGNAMSGQDIAFHIMKGGGQKVYLGYKNVPSPYKWPETIVEKGPISCFNRRRVQFADGSSDEIDSVVFCTGYNSIYPFMENRLRITCKSTLYLKDVYKGCLYMPQGDNRLFYVGAVRGLTLEKQVSEDEMRAYVDKWMTKAMGIREHADIVTYQCELMADLAKSSGYGMQYTLSLPLFLEWIKHRNDDAWTYRDHQFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3N6</accession>
    <name>A0ABY7F3N6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PTPRS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_031349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="316"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR16755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="491" mass="56430" checksum="4201471300192DA9" modified="2025-10-08" version="1" fragment="single">MQMIMSVVCAVLITVFPVQRRLITFIVKLAERGIFHTIMDNAKPAIRNASTMNAIRLREDVFKDALTGSGIKPATNNTCENSMCDINGICTNGCIANTFGKQCENTCDEYCTQNGNKTICSEKTGMFFTAAKPNTRGDFVLKLLKQKRKTKLFNSSTWCWYCRRSLVLAAIVVVGLFLIRRRRVNLRIESKAHEKEPEIFLEMYAKVNNGSTTREENPKRDTDNFHSVTVIRPPNYQSPPTNRFGNEKTPILTEDNLEIDEDDASARESAIIFEENGGFYFNNAEEISKIKLNVTDLPEYVHNLCFKDLEEEFQKIPYGLVKAYGVSQTNLTCTKIDDDTRVLVRGGETDYINASFIDGFKRRNAYIATLGPMTKQLGDFGQFWRMVWQQKVEKIVMVTNLVEGKKTKCEQYWPDHYQRNMFGDIKVVCKDEKLYKDFIWRNFTLFKNSKKRSLHHLQFTSWPDKGVPDDVTSFIEFRQRVNALASTFDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5B5</accession>
    <name>A0ABY7F5B5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTPRM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_031599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="191"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR17005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="298" mass="34039" checksum="708DB5AC11BDDC8F" modified="2025-10-08" version="1">MRHDRANMIQTVNQYEFLYSALVSSLSDISRPIRGTHFRKYINQMGKEGFNRQFQEIATDLAGSLIAHLELLNSLKARTRFLVVQSPMKENVIDFLTLLSKEKCTCVVSFEPYTDKQKKQNVGLYFPAGDHILKQGMFQVRCTKQENHGYCTKRLLTIKRNEPNGQSSEREVTHFEFNAWNYTSDVPKSSKDFLDLIKSVDANLRETSNRGPLLVHCLDGTGKSALFCVVSILVEKMKIDHEVSVVNTIRKVRSRRTSAIPNMAQFKFCHECVLSYIKSFDYCQYSNFTGSVTSASTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F6E7</accession>
    <name>A0ABY7F6E7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DIAP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="380" mass="42136" checksum="5E175054111620F1" modified="2025-10-08" version="1">MFSGKTQPPEHLTSASSSNSSSSRSMSTKGRFDQTAQPTSLVPQKGFAYKASQYQSLPVALTQTKNTQYTTFSTPVSGLKQTGLLVPLKHIRRAVADIYTFAVQPTEDPQNQFWEKQVAESKQISPKTQRRPQNPSSTARNNATARQTPNSSSSAVVSSTKFSKYPNYTTTASRLVSFKACQNIATSTRLLSEAGFFFAGTEDCTRCFYCGIGLRHWSENDDPWTEHARFSLDCDHVVSEKGREFVNLVKLALELTNEKETGAVQTADISKLSTPNARQDSSDKIDKLMKTEAAQSVLENDYSEELVKRAIVKVLRSKVLSRENQHLREKTLCSYCKRLEVSLVFLPCGHLVSCNTCGDRQKSCVTCGSNVKGTVRTYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F6Z0</accession>
    <name>A0ABY7F6Z0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_031057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF14">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="5"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR16463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="650" mass="74989" checksum="689C92A83A7B86A7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9A5</accession>
    <name>A0ABY7F9A5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="89"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="627" mass="73262" checksum="82A43A45903907D2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9T4</accession>
    <name>A0ABY7F9T4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR18104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="572" mass="66606" checksum="2E1A0BC926AF9A5A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FA27</accession>
    <name>A0ABY7FA27_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Short-chain collagen C4-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF18">
        <property type="entry name" value="SHORT-CHAIN COLLAGEN C4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37699" checksum="6070A5BB89DE9AF4" modified="2025-10-08" version="1">MTESDEPLAGVSPEEPTQPLHTSTPKKPIHTSKTGKGRPVHIYAPQVKQEKADQFGELETGQKRVLERITEQQNENEKQKKMLETISEQRTIVDKLQNTTEELETGQKRVLETITEQQTVNEKQKKILETMSEQQIVIDKLQNIIRGSKSTNVGTTYTRWGKPSCPGNGTETIYSGLVAGSHYTHKGAAANYLCLTQQPSWNKYNDKQEAGGLVYGAEYEFYHRSRQHFFGREIIDEDPPCAVCRTERPTVIMIPGSRHCRDGWTMEYHGYLSSGSYGQPAATEFVCLDVDPEVISGGRSNNNGKLFYLTEIRCGSSSICPPYVNGRELSCVVCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FA80</accession>
    <name>A0ABY7FA80_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1 feedback regulatory protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GTP cyclohydrolase I feedback regulatory protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_000843</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GFRP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1410.10">
        <property type="entry name" value="GTP cyclohydrolase I feedback regulatory protein GFRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036717">
        <property type="entry name" value="GFRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009112">
        <property type="entry name" value="GTP_CycHdrlase_I_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16852">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1 FEEDBACK REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16852:SF2">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1 FEEDBACK REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06399">
        <property type="entry name" value="GFRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69761">
        <property type="entry name" value="GTP cyclohydrolase I feedback regulatory protein, GFRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR19005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="97" mass="10957" checksum="CF6A7702B5EA93EC" modified="2025-10-08" version="1">MPYVFVSTQIRLETGPTTVGDEWSDKELMDLLGATLVKALGNNLLWLTLCSILYHSSEYQTEDPPRLVLNKLEQAGYRLVTTTGVGQTCIWTMFRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBA1</accession>
    <name>A0ABY7FBA1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ZN648-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_000282</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="327"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR18444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="638" mass="73440" checksum="42298F3EE3F93E52" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCS3</accession>
    <name>A0ABY7FCS3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NMD3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_031675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046801239" evidence="2">
        <location>
            <begin position="28"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="4">
        <location>
            <begin position="53"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="3">
        <location>
            <begin position="117"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR17081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="272" mass="30714" checksum="35E3A426243D2ACE" modified="2025-10-08" version="1">MLLDLAAFIRLIFHLLPILSFSRHVCAQELISHDVRNNTFNYKHTFSVTIVPICKDNIVCLPKKLASSLGNINPICVCFKVTQTVHLIDPNTLQVAEVSGPVYWRSPFASLCSPRQLIEYMVMDVQYVNDRDKPVIRGQVSQKHVLADLWVSRMSDLGVNDQQFFCKTHIGHLLNVGDTVLGFDMGNANLNNDHIEKLKAENLPDVVIVKKVFGDKKKRDRHHSDKVPVDTDDTDDEGVPQISLQEMLDDLHIGDDATEDVATPEESPRLCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FG21</accession>
    <name>A0ABY7FG21_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="34" mass="4225" checksum="06F9DF1535F78B3B" modified="2025-10-08" version="1">MMKPYAGRNLTKEQQIYNYRGRRILWDQSHGRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FH96</accession>
    <name>A0ABY7FH96_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027897">
        <property type="entry name" value="DUF4559"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15112">
        <property type="entry name" value="DUF4559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="759" mass="87155" checksum="3DC0EA24F771FD55" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHP6</accession>
    <name>A0ABY7FHP6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_002066</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="4">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="4">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="3">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR20228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="460" mass="51692" checksum="03367A9A2E513543" modified="2025-10-08" version="1">MATGFSGSELHAGDFEYDFPCTECQKHGLNSEAVYFCQQCTRQFCGPCLKQHDQFYRGHPILGPRKRDLWGNVTSMCKLHPGEEMKVFCRDHRQTCCVLCLEELHRQCKQVKLLQHIAPKPTNQPESENNEKTTHNDELPLKLKERVATTKHDTSPVVTAIHNNRPYPVKEGNCFNVKLEHDRYPCRIYGITVLPSGEIVITDHYNCNVKLLSPNYAVMDHFSTVIQKPWDICAVSDNQVAACTEGREILFFNVKNSKLELDRKMPLDVCCYCIYSVSYMAGHLYLSSGHTLYQYTLAGQKVREINLSNGHACFSAGNYLEIDETFRIIAVTKNRQEPTTTEKNPQPEGLGREVEGWDMKVDGVGKRCGREVDGVVKCKGGAEGVGKGKAGIYKWMVWEKQMEGVGKGCRREVDGVVKCKVGKLKGLGREVEGWDMKVDGVGRQVEVVGKGCKSEVDGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIB6</accession>
    <name>A0ABY7FIB6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ACHA7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_015814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044981914" evidence="5">
        <location>
            <begin position="19"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="29"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="233"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR21840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="403" mass="44647" checksum="BA2ED310D1B1EAD4" modified="2025-10-08" version="1">MKELLFCVLAVCVTEAHAGVSATDMNTHLTTTFTNYDSRVRPLLSDQSQAVGVSVDLHLLGINNFDSSEQKLETTAFLEITWTDEVLHNQWHDPDVPEVLIPQSDIWLPDLALQNGFETLTGLGNKFYNVRVKSTGVVTWRPYHVFESACAVDVTYFPFDRTTCELKFVVWSNPKNLLMATVGTGGLDMTGFSENSEWSIELTEANNFETTTSSGVTFAIQMKRKPLFYLLNILIPVIMLAVLNAFVFALPASSGEKTGFAVTAFLALAVFLTIISAELPRTADKVSTFSAYLFLVTFLSALISMITIIQLRLFAREPEVPVPSSLQSLTKCIRRMRCRTCFAKSGGYVRGLTIEEVKRRLSDDVTWEDAVGALDFVFFWVFLFLIAGITSGCCVIAVKGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJ17</accession>
    <name>A0ABY7FJ17_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LOX5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_016054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020834">
        <property type="entry name" value="LipOase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00087">
        <property type="entry name" value="LIPOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00081">
        <property type="entry name" value="LIPOXYGENASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="6">
        <location>
            <begin position="51"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoxygenase" evidence="7">
        <location>
            <begin position="167"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR22080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="716" mass="82354" checksum="8DA0B5AF7B06814F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJY7</accession>
    <name>A0ABY7FJY7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">COX15-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_015025</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR21051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="135" mass="15046" checksum="BED727E2BAE56555" modified="2025-10-08" version="1">MVRGMSHGLMATVFITALSGAFVAGLDAGLTYNTWPLMADRWIPTDLWAISPKWKNMFENATTVQFNHRYLFPLPPRARMAVNCLFGMALLQGTLGVLTLLYFVPTHLAATHQSGSVALLSFATWFAHEMKKMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKH9</accession>
    <name>A0ABY7FKH9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RNC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_036362</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd19877">
        <property type="entry name" value="DSRM_RNAse_III_meta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058938">
        <property type="entry name" value="Helical_CED_Drosha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044442">
        <property type="entry name" value="RNAse_III_DSRM__animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26050">
        <property type="entry name" value="Helical_CED_Drosha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="1069"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="1301"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="9">
        <location>
            <begin position="1462"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="460"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="669"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1566"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1638"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1004"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1671"/>
            <end position="1684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR22693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1684" mass="193252" checksum="37088EE8793F880A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FN45</accession>
    <name>A0ABY7FN45_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_016077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF3">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR22103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="502" mass="57091" checksum="2990A3AAA5A946FB" modified="2025-10-08" version="1">MTSEKQLRLPPDDLKWEKNKSNAWPKLMYEDLVDYLIHAKAYDGKAMKSFRSLYGYNYVQNGWMGDMWSIECEGMTYIKAKISPSQPGVGRKDYNSWIAVSSENTVETGHCSCPAGNARSCSHISAIIYAITLAWANGVGGETCTDKQRAWGKGAAQVLSHDTISDMVFDRPSPFQLQPCTEKTANKTNTDTDCPPRTEQFLDHSDLQDFVSNSTVANIWECKGTMLYKMLHAPEVKRDINEEILHQEHCENALYPVQVPLSCAKCQTFYDKYVNISSEKIQMLAKSTENQNTCVWTDSRKLRLTSSKVNDLPKTKRANPNKFVTNQIYPRFKGCFATRHGQKYEPVARAWYESVSGHKVRKSGIVVSLTEPYIAASPDGIIDERTIVEIKCPTRPLEDLISSGKYDVLLEDGQPKLSPKGKNGYYCQVQVAMFCTESTMCKFVVWTAEKQCVVDVQYSKDFIKGILPRIRDFYFKHLLVRLTDEFQASRLKISPEYKSLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNV2</accession>
    <name>A0ABY7FNV2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HPCL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_036663</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR22994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="159" mass="18950" checksum="65EA11D23CDA96AF" modified="2025-10-08" version="1">MAFEKEEIQKWYCDLLRSKDMIMDRLTHDDFQELFYSVFANNPRDFVDDTFRIFDPNNDGYVDFKEFIVGVCVYGTGTESADRTFRWAFLMYDTDGTGKISREEVAIMFKGIFKIATRSVSNKGNIHQNSFNHDFVDDSRRNGRPNLYGRRQRRWQQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPE3</accession>
    <name>A0ABY7FPE3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">TWK18-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_016555</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF335">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="216"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="385"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="545"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR22581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="651" mass="72838" checksum="A3C5BBEFAB73B7A7" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQ43</accession>
    <name>A0ABY7FQ43_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="5">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_037401</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013048">
        <property type="entry name" value="Meiotic_Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01551">
        <property type="entry name" value="SPO11HOMOLOG"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="14">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="14">
        <location>
            <begin position="112"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR23732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="212" mass="23711" checksum="EA4B89E6FC5C0ECB" modified="2025-10-08" version="1">MYYQASGDFGNQHTLDGLVDNISCMLGVPRWHLHVLASSKGCMAGDLRFQDVDNNFVDCRHTQMGILVPNHVNDLVTSANFILVVEKDATFQKLLETRVCEKLDPCIVITALAFETSNLAVPCMKWLGLLPSDIERLGIPATALLPLTKADRDKGRDLLSRPYMTCLPHWREQVECMLQLERKAELQSLDSISPSFLTDVYLPSKIRCAGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FS02</accession>
    <name>A0ABY7FS02_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_038031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR24362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32737" checksum="6D2DF273B8BF2BD0" modified="2025-10-08" version="1">MDSPQDESRTEMLAVGIGDDESSQQNDSSHGQSNSRSTCRRWFFTILIATITLAVAFGIGYFSKPLISTEESHPNISKEHGVQFLRQRNSPDLLVNPKQPCNDTHYCEKCTATVISSKHRHEHEGQGQVCRKNPLIEKPDCFRCNDSCISTVNLTNLLGQHIICNTTVEEIVCCDLIQMAPDKCGNNGKIICNNVSNPPFCNCNYNWTGLTCDQIDFQEVMCNCFTLGKAIAYADSMKSCNDAGRPANWTECILDGERENTPMNCICAPLNTTDIRFHLDEKKDLQNCSFSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSV5</accession>
    <name>A0ABY7FSV5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_010799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="2">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="661" mass="74464" checksum="757033EFD0534B5A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVQ5</accession>
    <name>A0ABY7FVQ5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Histone-arginine N-methyltransferase PRMT6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_011068</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF73">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="8">
        <location>
            <begin position="270"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR25364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="385" mass="44397" checksum="3643D4EB9153B56A" modified="2025-10-08" version="1">MMFFIVDCRSYICFWPMETGFFWMQALWVWTAVVCVLMELVHSFGRVTGYMSSQESFWRTEDEKPPGEEADRKRQRHDCSYFKSYADIGVHEEMLSDTVRTNAYRYAIFKNYERLRGSVVADVGAGTGILSVFCVQAGAKKVYAIEASDIAGQTEAVVNENKMAERIDVIHNAVESVKFPEQLDVIVSEWMGYCLFYESMLPSVIHCRDRWLKQGGLMFPSTATLYIAPFYDAEYDNRLEFWSEIRSVYKLSMESMKSYAKQSIAKQVHVNTIPPEAIQAHAQKGEFRFECFGRTQVHGFCTWFDVGFPEGVTLTTSPYAEETHWSQTAFYVDEPFPVDQEVCISGSIHIRPHREASRFLDISITHQVNNGPKHTRKHLMNDCFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FW50</accession>
    <name>A0ABY7FW50_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RAB7A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_011924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR26220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="150" mass="17067" checksum="CD21214425942ED7" modified="2025-10-08" version="1">MYDREIWDTAGQERFQSLGVAFYRGADCCVLVFDVTMPNTFKSLDSWRDEFLIQASPRDPENFPFVVIGNKIDLENRAVSAKRAQGWCHSKGDIPYFETSAKEAINVEQAFQTVAKNALSQETEVEHYEFPDQIRLNNDQNKQSQGGCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWZ0</accession>
    <name>A0ABY7FWZ0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_011348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd19776">
        <property type="entry name" value="Bbox2_TRIM25_C-IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR25644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="329" mass="37622" checksum="99A6FA6C1D5064AD" modified="2025-10-08" version="1">MEILCDTSSKTTSDSEYDYTCSPCNDEGLNKEAQYFCGECAQFYCNECEQWHKKIRKRHVVLGREDSRQWLQAPIQSVVEDLERCKKHPNKALELYCGGHDELCCHLCVANNHSRCSVVHIPVLAVLGFRETDEFNRLPDEVEELRNQLEEFRESRKRSKEKIETSWYKALMDIKVLRGKIIGQLDTVEKRTITEMIKVMAPSVEILTKDVDKCNDMRDRLKCFIDEIKSNKSESLSYVGFTKCKSLTAEANIVCKEMIKTKDFEIVFQPGSNVETTVSSINTFGAIFDVNHISPNCMVTSLRHVTNTNSLIMGLSGHIEKGIAVLELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXK0</accession>
    <name>A0ABY7FXK0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VGLL4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006627">
        <property type="entry name" value="TDU_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028184">
        <property type="entry name" value="VGLL4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17604:SF7">
        <property type="entry name" value="TONDU-DOMAIN-CONTAINING GROWTH INHIBITOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17604">
        <property type="entry name" value="TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00711">
        <property type="entry name" value="TDU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="468" mass="50307" checksum="075D5B2B56A3CB1E" modified="2025-10-08" version="1">MLNLDPTLEQRSAMSLLEPRLADLRAGFGGYSFGGPGISGLPPSPLLPLWRAPPPGPPVSLCTIPSCQCALSVSRSYLSAPDLYDYPAYSAYSAAYSWYLKSAQDSLYKGLPPMGRPSPLHDRTPLSGSPPAPPMEHSDHRASPGKLLPTKISKHERVKAWLEVSTRPPKYEKESSHPVNGTTHRVVRSVTPPDYHEAISGEGYQRASYLSSHGGLRTPPPHPPPRYPHPPVDLHHEAPLNLSLSNPGERQGRSASPLSRPSVITCATVPERRYDSASNGSLSPSGKDSEEHFRRSLGHKYPQFLVKSQSVTPSPPPPPPAISHAISHILPPSPRERTASPVANRTSPPETNGHKNVSITGSVDDHFARALGDSTWSALKAKTGPGEPPEPGSVDDHFTKALGDTWLKLKAEKDPAPRSQGGASHQFSLPHGMPQPLGRPGPTSLPHQLPQRPTSASPPSHHSPIIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FY19</accession>
    <name>A0ABY7FY19_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">I17RD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_011636</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039465">
        <property type="entry name" value="IL-17_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013568">
        <property type="entry name" value="SEFIR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15583:SF7">
        <property type="entry name" value="INTERLEUKIN CYTOKINE RECEPTOR-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15583">
        <property type="entry name" value="INTERLEUKIN-17 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08357">
        <property type="entry name" value="SEFIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51534">
        <property type="entry name" value="SEFIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="SEFIR" evidence="10">
        <location>
            <begin position="77"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="332"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="341"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR25932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="534" mass="59649" checksum="31C7DB73F3B0F811" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1M2</accession>
    <name>A0ABY7G1M2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_013516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR27812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="756" mass="84457" checksum="29C0747DE688A198" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2U9</accession>
    <name>A0ABY7G2U9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRNK1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="539" mass="60178" checksum="B62A5DAD14123AAE" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G355</accession>
    <name>A0ABY7G355_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">OCTB2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_014574</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230:SF158">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="19"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR28870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="339" mass="38426" checksum="D13107005D183B95" modified="2025-10-08" version="1">MFVSLTLTVCMLSVFSVCGIIGNVLVLGIYRHRRNTTARFFIITLAIADICSCLILIPLTIVTESLFYQLQYDAVCKMYNFLLVCNVQFSVFLMVIISIDRYFCICHPFKNVINTFRAKGIVICLLAVTSVFGIFDSWSYSIVDIKASPEPPTSFSLLKKYNNTTSSSQTPSLLNISSYQIEQGGNVTVSSRSERKGDSFCMPNLDNMEYYRSVRYTYASSYLISAVTDASATAIQDIHITNDNTISIAARTPRDTDRNQTSNIRTAAMLFASSIVFITTFLPAWLMALDAIEFNVIIFYMYFISHASNPFIYVFMSRSFRRELNQTLKLPFWKSVFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G470</accession>
    <name>A0ABY7G470_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Mediator of RNA polymerase II transcription subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Mediator complex subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED11</name>
        <name evidence="8" type="ORF">MAR_014023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019404">
        <property type="entry name" value="Mediator_Med11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22890">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10280">
        <property type="entry name" value="Med11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR28319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="265" mass="29238" checksum="17AF4298AE28A5EB" modified="2025-10-08" version="1">MGCASSTSGQKPNEKKPTALNMGLGVASGGIVMETNEMEISMGFETELVHEDLLQEESTQQHMYIELKYRRLNSAAEQLDGLGGLFARRGKILPNPEGSSADAACLQSVNMNNCVTSLPVNANECSFYIRLRLSLVTDTEFNMAASGPVERLQQLETIEKDVSNAILSAGKALEELSKEKPQMKMIENHTTGFMKTLEGVEVGLMKQINYLTQKDLLMGYHRMAHVRSRLEELEKIRTDGKPKLLQLAKSYSMPPMAKPGQLPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5V9</accession>
    <name>A0ABY7G5V9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_012385</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="89"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="260"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="387"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR26681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="680" mass="76149" checksum="7658D71869862BB2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6E3</accession>
    <name>A0ABY7G6E3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_014613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR28909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="467" mass="52275" checksum="2BBBB2EB699AEE0F" modified="2025-10-08" version="1" fragment="single">MKGSENCELRGVLVGILVEDILHVILLRSCLGHNSIADTEVVKTGMHISDRDANRGLNSWTMEDGESGNSYFAQNRIALFSCHFGPPINDTCIRESIQCMLFFTLSASEPTKQSCSLSSFVSSSKLMSFAVFGLVAETINHRIDMLEEKISDSEKRITEQVTDKITKVFDKRMSSEMSRMRKDMDNKIGDLRKEISSEMEGLNGKMEEIAKTPPNNSNTEDIKFNIVIRNLPFNESEDIDRKLSDLLRNGLKIQDSRWNGKKALSDSTPGVVVAKCNSLEDKNRILTAKNQLGKTLFYKKVFIHSDQTKEERQLASNMRLIMNTINNGHSNLRVQGTRVVNNRNEGTRNRQPYSNGIHSGFRDEIHSANSEGANNSCSRSNVNNDRSANRGRGAWGNGGQARGNNRGIAESHLKCNEQIFLNGYKWFGNNRDDIHVNAWSGSGGVGLFVKDNIFAEYDVSVVDPSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8B7</accession>
    <name>A0ABY7G8B7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRAM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="511" mass="58871" checksum="83E55ABBC412BB95" modified="2025-10-08" version="1" fragment="single">CSVLSIPPITVKSVRGKWITADNRRLWVLKHLERLGKIETINVHITGYIPPRKMTSKNGGVSIKVRGHVGGRWFSEPTKLTASTLEVQKKNTLVCAPCETNHNQPFVTEKVRDIDSHNIKYVRQYDNPDPNDYPDANDYPDANDYPNANDYPDPNDFPDPNDYPDPNYYPDANDYPDPDDYTDTNENPDANDYPDPNNYPYPNDYPDANDYPDANYYPDPNDYPDANYYPNPNDYPEPNDYPDANDYPDAYDYPDPNDYPDPNDYPDANGYPDPNDYPDANDYPDAYDYPDPNDYPYANDYPDLYDYPDANGYPDPNDYPDPNDNPDPYDYPDANDYPDANYYPDPNDYPDANDYPDPNDYPEPNDYPDANDYHDAYDYPDPNDYPDPNDYPDPNDYPDANGYPDPNDYPDANDYPDLYDYPDANDPNDYPDPNIYPDLIDYPDPNDYSDSNDYPDSDDYPDPDSYLDPDSIRLQPNHISRITYESAHADALDTESNDKRIVIGCQPIPFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9F6</accession>
    <name>A0ABY7G9F6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proteasome subunit beta type-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR29721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="138" mass="15444" checksum="58D71C81DC3B818A" modified="2025-10-08" version="1">MKIEEECLNDGFGYTPSSLFSWLTRVMYNRRSNINPLWNTYVVAGWDNGQGFLGYVDKIGVAYQAPTIATGYGAYIAQPLLREAVEKNPNMTSAQAAEIVDNCLRYEVAIVTKDGVEIRTPCASKPNWEIAHLIKGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9U8</accession>
    <name>A0ABY7G9U8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_033734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045386843" description="EB domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR31192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="137" mass="14482" checksum="FC30D7A540DD3ED0" modified="2025-10-08" version="1" fragment="single">MAMLPTSVLMTTLSGAGVCNCVSTHYDNNGDISGGECDKRKQLGEICTSHEDCTSFNKKTMCGSARKCQCRTNYYDSDGNVNVGGTCISKKKLGEDCSTNKDCTSSDSNSECHGRKCQCQSSYYDGNGNTGGGTCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAB8</accession>
    <name>A0ABY7GAB8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CADN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_032821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047234212" evidence="6">
        <location>
            <begin position="20"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="213"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR30279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="343" mass="37175" checksum="F6CAA72926908591" modified="2025-10-08" version="1">MAAGLLMACILLLVVSVKGFVVDEAMTTPKVNCVDTDNCDFLNVTYHICNDVQLAKEHCKLFCRLCDAVDGYWSDWGQWSGCDVSCGKGTRSRVRLCDNPAPTHGGDDCAGSKDEHDVCVLESCPGMFNFELTTIESTVIFNAVFSILDNITLVSYSLHVDGWDNWSAWSSCTVTCGQGLKNRHRACNATMGTMLGGGCIGNDQEQIACNMTSCDVVVLFYARSPTDRSISSNEKIVYVTVTTNKGGGYNSSNGVFTAPHNGLYLFTSHTCVYGSNYAYTGIVKEGTVLQQSASRSINYEECNSIQAAVELGVGERVWVQGTSTSTLYEDSLLICSFSGMLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GC60</accession>
    <name>A0ABY7GC60_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Guanylate cyclase</fullName>
            <ecNumber evidence="2 10">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_034059</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2 10"/>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF494">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="12">
        <location>
            <begin position="200"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR31517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="370" mass="42419" checksum="6D9DC9A3DD077300" modified="2025-10-08" version="1" fragment="single">MNCREVNNFTLYLSVSLPELLWMAPEHLRNYPPRQSSQAGDVYSFAIIIYEMCTRAEPYVSEIWYKSLDETLAKIKGVGTLKVRPTLREEDYFPDVVKLAKCCWHEAPPERPPFSNIRNVVKRIRFKRDAKPSQNVLDVLLNRMEQYANNLEGLVEERTQAFLEEKKRSEELLYQVLPRSVANQLRIGNPVVPESYESVTIYFSDIVGFTAISANSTPFQERPLLVVDLLNDLYSCFDSIIEHYDVYKVETIGDAYMVVSGLPERNGTEHARQIARLALNILHSLQTFVIRHQPNTPLRARIGLHSGPVCAGVVGRKMPRYCLFGDTVNTASRMESNGEQMKIHVSKATTRLLTRFNTFVIEERGEIDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GE23</accession>
    <name>A0ABY7GE23_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="104" mass="12106" checksum="CC790BB9A4808343" modified="2025-10-08" version="1">MIGSFSCVMRYEKRSRYCKVFLARETFSFKGKITKSLRIEKCLPPTFRTLLNYTNRLCPCGAHSSVDVYTRICFKWLMKEGLLQSSSTTRFAATVFMIMLHNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D858</accession>
    <name>A0ABY7D858_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">COLL2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_006333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050179">
        <property type="entry name" value="Trans_hexapeptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43300">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="45"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ93862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1416" mass="142949" checksum="DAB355B367F5A4F1" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DA90</accession>
    <name>A0ABY7DA90_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="126" mass="13263" checksum="B3FB9C97F543ED48" modified="2025-10-08" version="1">MIDLYTIWTIPVRKAECVSGCDATHSCDMKEPVIRLPDPEESKHSNEMVAQSGGAGSGSTFCKSGWFSVSAIISLTSSSDSISGGAGSGSTFCKLGRFSVSAIISLTSSSDKPKSVETKGKFMRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DB20</accession>
    <name>A0ABY7DB20_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PARD3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_006448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23059">
        <property type="entry name" value="PDZ3_Par3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052213">
        <property type="entry name" value="PAR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484:SF17">
        <property type="entry name" value="BAZOOKA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484">
        <property type="entry name" value="PARTITIONING DEFECTIVE 3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="151"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ93977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="722" mass="80326" checksum="6098904FAD3A0043" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DB63</accession>
    <name>A0ABY7DB63_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000180">
        <property type="entry name" value="Dipep_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00869">
        <property type="entry name" value="RENAL_DIPEPTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ93846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="394" mass="44222" checksum="E5268B42D1428B5F" modified="2025-10-08" version="1">MPTTHLPHCSVNPKSPHPDLDRARCVLQSYPLIDGHNDLAELYLAYANDSVNTVDLTSDLRLTWDKVLAQTDIPRLKQGLLGAQFWSCWVTCHSQYVDAVRLTLEQLDTIKRFIKKYPDTFQYADTAQGVIDAFDAGKIGSIIGLEGGHLIDSSLATLRMYYDLGVRYMTVTHSCNTPWADNWHVDEPGYNGTVLGGLTDFGKQVILEMNRLGIIVDLSHVSKSTMFAALEVSRAPIIFSHSSAFRLCNHHRNVQDDVLVKTKEEDGVVMVNFYTPFVVCPPNNKPTQELTDVADHIDYIKNLIGVDHVGIGADYDGAESFPVGLEDVSKYPDLFAELVRRGWSDIDLQKLAGRNVLRVFREVEKVRDSLREMLPVEGRLPWTDLVDTKCRTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DC36</accession>
    <name>A0ABY7DC36_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">FBP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_027926</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF13">
        <property type="entry name" value="SUSHI, VON WILLEBRAND FACTOR TYPE A, EGF AND PENTRAXIN DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0768">Sushi</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="C-type lectin" evidence="12">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="487"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="600"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="731"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="802"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="1000"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="1065"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="14">
        <location>
            <begin position="1144"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="1233"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="1271"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="1309"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="1347"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="1385"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="14">
        <location>
            <begin position="1436"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="1534"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="1093"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="1259"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="1297"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="1335"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="1373"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="1411"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="1563"/>
            <end position="1572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAQ95236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1601" mass="175417" checksum="EC04BAEE0C9AF0EF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCX7</accession>
    <name>A0ABY7DCX7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="200" mass="22757" checksum="64705B6CC41BFE0D" modified="2025-10-08" version="1">MFARSRYLVWLARSQCTPLELGNFPDMFNTTWWYFPPVIFLQTPTEHTTDCYSVVVPSHNTVNRHHCPFGDNGCMQTRVIEVCLPVPLQNVALPIFVSFFDLFLVRTSSSLGHLPPPLSLPASATSSSLTEIEKITPDIVCKLSANDMNRLGISIRSDMMALRMECVLYGNADDDNQACRADNLKFQNKYWKIFLMQTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DD22</accession>
    <name>A0ABY7DD22_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_006750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045701168" evidence="2">
        <location>
            <begin position="19"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ94279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="536" mass="59096" checksum="7723277E52EBB298" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DG41</accession>
    <name>A0ABY7DG41_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">RYAR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_028345</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd15392">
        <property type="entry name" value="7tmA_PR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005395">
        <property type="entry name" value="NPFF_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF29">
        <property type="entry name" value="GH23382P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01570">
        <property type="entry name" value="NPFFRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="56"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAQ95655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="391" mass="44602" checksum="36348287707AC01A" modified="2025-10-08" version="1">MDVSIMRENGAYNITSETKTNVTEMSAVKGPIVVPMYQQAIIITMYSIIICLSVFGNSIVCYIVFSSRKMRTVMNFFIVSLALSDILMAVLCIPLTFIANLIINSWPFGETMCPIVSFIQVVTVFMSSLTLVAISLDRYWAIVHPLRRKMSKRQACIVISVIWLLSLVIPLPTAIKARVHQYVNDSNAPFFCEELWENVTGQSIYNVLLLLLQYFIPLAILVFAYGRIIRVLWIVKTPGEAVNDRDKRIATSKKKIIKMMIVVVIIYAICWLPHHVITIAGDINITFYNLQGMNIVWTASHWLAMSTCMYNPFIYCWMNAKFRNGFIKVFRCVTCGLTKPRRGIEMQHMSYHHSGALSPYIACRVPSGLYGRGKLQVRDLRYEWSDIDGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJ49</accession>
    <name>A0ABY7DJ49_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FLuncharacterized</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_029676</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="44"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="89"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="190"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="310"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="382"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="476"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="571"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="694"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ96986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="789" mass="84882" checksum="DD1D1A2A34BE6CC8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJE5</accession>
    <name>A0ABY7DJE5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="322" mass="36205" checksum="2D354C726E0FB441" modified="2025-10-08" version="1">MQEGVDRWTATPRSTTPGRPLSVRTSFRPAIHDLSEQAARNSTGPPDDGILSVVSTCTPRVARSADSHGFPDKFQSPTPLLGQFSPEEAIRASPTSKLCFKSHNTEYLEDLHRQRVLVSAHHRRKLHSRLRRSRSTPVGGGRSGSQSRAVASDLSRHSSDDDSDKLDFTITNGQRLDEEEFKERINYRLINRTKPKVAYSHATLMPNGAPLSQVNGYQQTLVQNFPQYSQKYCSWLTRGFKVQSFHTNNRAVPDYNHARPPPPLVQYINRTKTVSATSRWPNRQSRAAGSINVVGFNKPQHQTLEFPGGRKVVVHTGEYRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKN9</accession>
    <name>A0ABY7DKN9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_029759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="216" mass="23828" checksum="C924A4545A91758E" modified="2025-10-08" version="1" fragment="single">KRGIQSDRSVFGTDASITRRRSCVSEVSRSVLGSGSHSQCAMNFWSTFVLRVLATALLFAVGLHAQSSHRRGRFRSGARIGSSGLPNHLRQAYDSAVSVDTGVSTTTSTTVTPMDDPNQYANSWNPYTPTLPAPENVDCYIDVQITRRQGGRCVQLGGENSRPYICQSGPHIDFAPRCRHVVLRRQQQQQQLLEQQQQQSGEQHTEDIGEPAPTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKV3</accession>
    <name>A0ABY7DKV3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OVCH1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_029911</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="46"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ97221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="215" mass="23732" checksum="57A1732480327295" modified="2025-10-08" version="1" fragment="single">TTVRPGAARAQNHAEGNASRYIVGGDPTYQGEFPHHVAILLDDEFHSQFDVNDYASSDIAVLRIGYGFTFNKYVGPAAIPRTREEEQKVRHIGDCAVVGYGRTNEAKEKYPNKLRKIEGLFLRNFKTCNSALRKSGAGGMSRTQMCSINPPKNVCVGDGGGALVCRKPNTGDQLVVGVTSFILSPCRTTGTAYYMRAYRFRQFIQRAIAKMDNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DL23</accession>
    <name>A0ABY7DL23_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFSD8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_022266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd17326">
        <property type="entry name" value="MFS_MFSD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ97893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="523" mass="58555" checksum="E3DB59FC2384A609" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DL60</accession>
    <name>A0ABY7DL60_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_029513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026664">
        <property type="entry name" value="Stereocilin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23412:SF17">
        <property type="entry name" value="OTOANCORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23412">
        <property type="entry name" value="STEREOCILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ96823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1035" mass="113273" checksum="3729A4C21374CD96" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMS8</accession>
    <name>A0ABY7DMS8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CLC4M-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_022400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF1">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 11 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C-type lectin" evidence="8">
        <location>
            <begin position="315"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="186"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ98027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="447" mass="52234" checksum="F330E14604A5B269" modified="2025-10-08" version="1">MKAHGSGHETSETITDLNTFWGTNEPNGGERENCMHLYKTVHGDLDPHDKQLGAQNKLENEDRNSHRTQSQLSCSGLIFLRLRVTMMYVLVNLSLCSRLGRLEKRLYLLESRIALDSFEFRQELEETKAVFNKTMDFINQNIENINSIISDKDCRSMYNKHDDFIKYRRILESGFRQLKLSVNLQLENHSKNIKHILEKINKLDARTSNIDENCRTGMDKYEELSKEIRDLEIRTQTKLSAQETSINEIRTQINEMESDDLKTIQTALHSIHAVISEKQDNTSVTKPMRKVFDETISLFLTLTLGAEVKCKHYEFKFKCYLIMTGEEPWEESKRKCNALKIRGHLPTVENDIEQEYLQTLSRNYFSLADYGVWLDGNDKDNEGTWVWSETSETITDLNTFWGTNEPNGGERENCMHLFKSKDYKWNDISCNRNMSFICVIDMSFIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMW4</accession>
    <name>A0ABY7DMW4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZFY21-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_029025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052113">
        <property type="entry name" value="FYVE-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490:SF9">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="69"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ96335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="393" mass="42763" checksum="C701C794BD2F9593" modified="2025-10-08" version="1">MHIEMARPLCTCCCCASSTRVLPLLLIDTRGEARLSLDGTSFNPAVIEGNADVFNNPHFIMEKRGWQPDQEAVTCPLCKCKFGGLKRRHHCRQCGLVVCNKCCNEKVPLPQLGIEEPERVCEACRPVTSAVTKSRVLEKTQPNKGKILMDGLSALTIYCKSQAFLNTVLDSGGLSAILPLCRCPDGTVALMAVSLLSVLLENPATHAALVDGRGEALRNLLSLVNVDNAQEDFSCGRPLLAVVRTETINMQVWANAACLVANLATSQEDQTSLAENRDALLDIVKSDVTNFDLLRNVIRGIANFAKFQQNSAKILSALPHMSRHCMTHEDVAVRLSALRAVLHLLQHETEATLTQLLIEGASDMLRTLTGAGDVMNAMFAAISQTHPDLSRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQH9</accession>
    <name>A0ABY7DQH9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ98972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="66" mass="7671" checksum="F5CEA5CBB2E2BC9F" modified="2025-10-08" version="1">MIICLSPRIVRSSCIHWLQGTGRHFFEQWGNTRGWSKENTSSCFCGLLHDKLYSCCSTNRDKVLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRU5</accession>
    <name>A0ABY7DRU5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondria-eating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_023677</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031981">
        <property type="entry name" value="MIEAP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16026">
        <property type="entry name" value="MIEAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondria-eating protein C-terminal" evidence="3">
        <location>
            <begin position="299"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ99304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="376" mass="42887" checksum="1AB94AA3C5A51C93" modified="2025-10-08" version="1">MGNNRSKGGRDATCKVEDETLKEVEEEVAEWSRTIQIIKGNQGGEGAKMGERDLIHRMNTTAKKISSYISNVDEDQTGQAGLQSSVNKNGSMNPTSSSKRTQNEDGTCSGHDREVHINPSDLVVQIGFLKADRETMKKDITRLQEEISRKQAENDQLRIRRFILVLYTVYIMHSAYTFCVRNSNELVTKMEAVAEKLFEDITRREHSLTLPQSLIVLEIQPLGRVTNPLLALEDHFIERHWKPKQRKEAQTDLNKQTSVGPTNMGQELIKMRKGVAVSMVPVVQHAYLRDRWDKECIESLKPFIKKSLFICWMMVVQTPPMVFDSTTKPDSRFDALLYRQYTASGDTVEYVVWPAMFLHEKGSLVLKGVAQPKKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWG7</accession>
    <name>A0ABY7DWG7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR01041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="314" mass="35612" checksum="DBA96F6CA125A3A5" modified="2025-10-08" version="1">MIENKETVDFSKIKNRVIEICANTNVHIGASKLKSKHIKHIKHVLRQVWPELRFIPREGMTDIVCSRELSVDEALCKAVSLEKSLNEMQEQSDLDTSLKESFENSDAKDVAILHEAATILRKRIKHTKGLQNEYYSSDELSLENQRDFLDPLLVRFVTWLSAKSKLDDGVDLNETVVEQTIISISSDITTLVQPSVITPKHLGLTVYLHHTFGSKKLIEDLNVHGYTLPYTEVRHFLTSAALHTISSQQKTPSDGHSRPRDNLIIAAADNWDHNENTLSGKHSTHAMTSILVHTTPSIPQSADRIKREWVFVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZA8</accession>
    <name>A0ABY7DZA8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="12875" checksum="DDAB01F6BD413FE5" modified="2025-10-08" version="1">MFVEKIPFDKNFFENICMKADNLIRIAILPELVAKVYTTLVVDKNDLNQSSCTPPLKSSENIQSTDKSDEKLYCVCNQVEFVLQLGNGFAMYVGSCHILSAGVLLVINWIIVLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E049</accession>
    <name>A0ABY7E049_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_009693</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF12">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR03135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="292" mass="34327" checksum="FCC7B45E681E5E8F" modified="2025-10-08" version="1">MELIVDKFNHFTRFYGWALSVSDKRVADWFLMQGYTPTLVITAIYVIFVTKIGPAFMKDREPFKLKWPIVIYNFICIAINAHICTSLLYNTTMVGYNYSCQPVDFSDNPFEVNIAKALWWFYFSKCVEMLDTVFFVLRKKQNQVSFLHVYHHATMFPIWWMGVKWVAAFFGAMINSFIHVIMYTYYGIAALGPQYQKYLWWKRYLTIIQLIQFNVGIAHAIQSLVFQCDFPLWMQYAVVFYAGSILALFLNFYFQAYIKSQRNAKTKGKQEKLQNGEKNGVANGHSEPKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0D2</accession>
    <name>A0ABY7E0D2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SPT6H-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_009996</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SPT6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00164">
        <property type="entry name" value="S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="966"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1322"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1334"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1352"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1380"/>
            <end position="1391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR03438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1440" mass="165134" checksum="52631E6A0D844C13" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3W2</accession>
    <name>A0ABY7E3W2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">S39AC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_020056</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049406">
        <property type="entry name" value="ZIP4_12_EF-hand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF4">
        <property type="entry name" value="ZINC TRANSPORTER ZIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21116">
        <property type="entry name" value="EF-hand_Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047155291" evidence="8">
        <location>
            <begin position="23"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc transporter ZIP4/12 EF-hand" evidence="9">
        <location>
            <begin position="254"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR04687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="681" mass="74688" checksum="484A763876FB8AA2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4E2</accession>
    <name>A0ABY7E4E2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_020251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dermatopontin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026645">
        <property type="entry name" value="Dermatopontin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15040:SF1">
        <property type="entry name" value="DERMATOPONTIN-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15040">
        <property type="entry name" value="DERMATOPONTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14704">
        <property type="entry name" value="DERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045307575" evidence="5">
        <location>
            <begin position="20"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR04882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="328" mass="37230" checksum="240E5B505EB5E694" modified="2025-10-08" version="1">MAWFLVLSLLVLNAVNVHSAANNFDQPVNFNCPKKSQSINHIHSQHDNYREDRLFTYECKEIPTVSSDLRATCYKTGYVNAYDEEVLFKCEPNYYINEIQSSSYSKTIQHLTPITRLLLPTHLLHGYLLSLELNCSYLLNPRPTNKAITLSSNPHPPPPAQACENFNIKSTHRLSFPVHDGLQLIEVSQFDFQFLHLSLNQQSNQRLDLSLLNRCQCCSSNASPVQDKLWSDFPHLPTPPLSPVLFQQCQSSPGQTLVHLTPVTYPPLSPVLFQQCQSGQGQTLDQLTPVTYPPLSLVQYQQCQSGQVPYLLRCFLLHIDHRTSLNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4P7</accession>
    <name>A0ABY7E4P7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47705">
        <property type="entry name" value="AGAP000321-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47705:SF1">
        <property type="entry name" value="PNP_UDP_1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="416" mass="46692" checksum="A509FCE94A7F6389" modified="2025-10-08" version="1">MTPSKKGKATHIRIERRKKLDMNGTESDERHHVGGGEHKGLVVNKSSQGNAEEDLGAAHVQLAFNCFMVDMKTQKHLVRLRKLKTLDQCTRLIVNVEDATEEMLREQLEELEKRELVKKLENEVQVVKQMNVVSASNQPTIAIITANYCEKMAVDAMMENKTTYVKYKVKGESNAYTIGFIGEHKCVSTKLPMIGHDRSAQISSGNTTTRLLGTFQQVEHVFVVGVGGGVPHFTNYFKHLRMGDEVIKNIKAVRSQRHFAPWEKYMKDGLELLSTQEADYNRPPTETDRLTMMIGEGNIIEMQHPHHPDGIDERHGMPKVFFGAIGAGKRFARDDDLRLDFAAKNGLQTFDSEFDQVLGGILGSVKDSFLFIRGIADYSDGMQKTEWQPYAALVAAAVTKSIIKSFKSPYGSEDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5T1</accession>
    <name>A0ABY7E5T1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="139" mass="15540" checksum="07E8373F27ED0E60" modified="2025-10-08" version="1">MDVKFNQNKCFAFLVILSSFVTGEYYFLSNDATVWGESGCTLAFPNLTFTDEGINVTNDGMSSLILPTEGVWIGLYKARLSFAYVGCNQINDTDVLLVRDLSDCRWQSGCDTFGVREWDTAVESDGQGEITLLRIQKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7W9</accession>
    <name>A0ABY7E7W9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VL96-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_020222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd22758">
        <property type="entry name" value="OTU_232R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="813"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR04853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1494" mass="169616" checksum="CBA44B515014E4CD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9S1</accession>
    <name>A0ABY7E9S1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RBBP5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_020867</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR05498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="127" mass="14505" checksum="88FA0718E58F7642" modified="2025-10-08" version="1">MWKKCCFSGDGEFIVAGSAKQHTLHIWEKAVGNLWHPVRPIIVSISSGVVSVWAQNQVENWSAFAPDFKELDENVEYDERESEFDIAEEGMEKKDLKEIHPLLNIKKPNEKVPRKPSTKTKIEEANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAC2</accession>
    <name>A0ABY7EAC2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Allantoate amidinohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_019475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the allantoicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="3">
        <location>
            <begin position="51"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="3">
        <location>
            <begin position="160"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR04106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="257" mass="28471" checksum="B1592590AFACEDC0" modified="2025-10-08" version="1">MATAVINQFGSTSASEPAFTAYNDLASTKVGGKVLFATDDWFAQAENLLKDWEFIVSLSELKPGFPKSSHNYFHCSGKKKYTHLRLNIYPDGGVARLRVYGQARRDWSKVSERKIVDLLSALNGGLCLQCSRSNGGGGRNLIQAGRGSSVEDGWVVTPLVEVDTNNFKGNFPDVCRVEACFLDNSANDLDTNIPKSKWRTLLPVTKLKAHNQHFFYQDQLEKNTGVVSHVRLTVMPDGGVSRFRIWGTKANRAIAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBI8</accession>
    <name>A0ABY7EBI8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_017360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF3">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="130"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR07402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="213" mass="23491" checksum="BADF7D64C4087609" modified="2025-10-08" version="1">MISRNRSSVHTTATKNNSNFCILVRGVVYNVTVTMRPKKNAQTKPSTTSVLQPKCYRIYNEVSSLSAVKLKQLCGQYNIDPTLPKKAKIQRNIVHSIKYCENEESSSFAILSARCNASQSSNADEVKVLFVVIDKITGEPYSGYCTCTAGFSGTCGHVGATLFLVAEQMANGVAKFTSNDKRSCTDKLCGWAQPEGSHVEPDIFENFNIKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBL1</accession>
    <name>A0ABY7EBL1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YMD2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF21">
        <property type="entry name" value="CAPSID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="402" mass="44855" checksum="5018981B4FCD5A4A" modified="2025-10-08" version="1" fragment="single">MSVFNEEKFREGLVSELSLFDLASTQTSVTNVYNEEIRSMSQTAGDSPFEFRISGQSSMDYLDLKNSQIYVKCKLEKLDGTSTGVLTVDKVGPANLFHQALFSTVEVTLQNKATFTCNYNPYIAYIQTVTNYGSDAATSQLTSQIFAMDTAKFADVTDPKGFNTGLFERAKLTESSKSVELQGPIFHDIFSMSRYLVNQVDVKIKLYRSSNNFCIVAGDATEYRVLKDKGESRHGHSKILENQNALYPYDKVEVKSVSIATGSTTYSWDNMFQGRRPNKLIIGFVKSKAVSGNYKTNPFNFENCSIQQIAVYCDGLPVGGNPHKLDFNLTKGASFIRAYNNLLLSNGKWRHDEGNQLSRGHFEGGSALFVFQIEPNFSHHGEYLSLVKTGNVRLDVVSKTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBZ3</accession>
    <name>A0ABY7EBZ3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FBN2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_017506</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050751">
        <property type="entry name" value="ECM_structural_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034:SF209">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="AMOP" evidence="7">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="8">
        <location>
            <begin position="136"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="515"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="556"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="621"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="703"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="746"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="872"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="931"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1098"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1184"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1324"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1334"/>
            <end position="1351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR07548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1526" mass="169998" checksum="A3702ACC40AE1DF5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECA6</accession>
    <name>A0ABY7ECA6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CNTN6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_021801</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="143"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="333"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="415"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="588"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="692"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="747"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR06432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1049" mass="118437" checksum="31ED486348D31942" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ED87</accession>
    <name>A0ABY7ED87_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IAP3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="105" mass="12044" checksum="5979DE86ECA7BB46" modified="2025-10-08" version="1">MKPTPTSKDSGLSERQKNFQGYINTTRTSRGFIYCNPLFVPAGQDFDRNQGNQSCHDSTILRPEYASYKARLATFNDWPEAESQRPQLLAKAGFYYTGRLKKRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDI5</accession>
    <name>A0ABY7EDI5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TI13B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tim10-like" evidence="1">
        <location>
            <begin position="215"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="288" mass="31440" checksum="44999CE28A1BC072" modified="2025-10-08" version="1">MLSTISLAMFSTELVTELSLPCSSSLTSFELSSCTLKEIPSLEQVSLSSLLALEISPSFELAAGKKSSIKLSMELSDPNGFIFRLKLLGSTLSKWSSCSDLDLDGAVSLDRLGEYHKVKHGRDGCTLDLEGHVPSQENVDGCLHDLGHVRVNELAVVEGKGHQKEVKHATLYQHTGVLHSTAQCLNLEFINNMNFSSGSPPGLNKGEDIETALNQYQQQIMMQQSAKKLEEAVDSCFRKCVTKPGSSLDKNQQKCLGQCVDVYLEASGISYRKSDLGIEEVRAKPLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFY9</accession>
    <name>A0ABY7EFY9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_018888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="102"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR08930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="618" mass="69642" checksum="9CBE4500D63AE062" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EG62</accession>
    <name>A0ABY7EG62_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="59" mass="6753" checksum="BC54A517E9683A9E" modified="2025-10-08" version="1" fragment="single">FIDGCEFVYIDIGVWCESKHNNSINSAIDHYFKTGEEDSGYKCLCIETAPYFYNDACIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHY6</accession>
    <name>A0ABY7EHY6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TAF5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_034571</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR09495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="503" mass="57707" checksum="C1CC1CEEB93CFCC9" modified="2025-10-08" version="1">MTILYPVFVHMYLELVYNGHEHHAKKFFLKYSLDQEPYYAEDLNKLSTVTKPEHMKGSQIMENFKSSKFVLKMSRDSYTHLKLFDGVPRTKHQIDMTSGGLLGEAARDANKTKILHGLLKEPDINIPVDDDDDGGGDGEDKPKARFLPLYLRTHGMSLSNISFFKLLLIPWMLKALWAPFVDKYGTKKKWLMYSMFGLFTTCLFGMFSTPDHLYGLALVLFLFNFLTATQDIAVDGLAVQILATSELAAGNIAQVVWYKIGAVFSGGLLIWLTETFKLRWGTIFLNVGIFYFCAFVFVTKVVPSVKFSQLEMEIMPVKNEENKEENIPTSKQEKGSSKPKNERHWLLEHFKAVFSSKETRWTLGYVLIYKLASTVEFWTGIVGQATSIFGSLLGGWLVSWFKNCGATNVYHVARQWCSHNNDLHLDDVLFTKVTKCNSGQPLHYHGNRRSPGQTDILRSDWFICRHIWILFGFSVVCYIGCFGLACFNELSFEFKRNVEQYWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EI29</accession>
    <name>A0ABY7EI29_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LN28A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_018555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051373">
        <property type="entry name" value="Lin-28_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46109">
        <property type="entry name" value="PROTEIN LIN-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46109:SF1">
        <property type="entry name" value="PROTEIN LIN-28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR08597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="94" mass="10028" checksum="40398AB622A20699" modified="2025-10-08" version="1" fragment="single">GEEVEFESVPSDKGVEATYVSGPSGQECRGSDRRPMSRKKFRKIRCHNCKSTDHLIADCPMKDPNDQRGSRKGSGNSLNGGSGGEYSGGATGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EL70</accession>
    <name>A0ABY7EL70_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DPP6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_034793</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="4">
        <location>
            <begin position="16"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR09717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="251" mass="28897" checksum="F98BBD511A04FD40" modified="2025-10-08" version="1" fragment="single">MRRFSRSIPEESILKIYDHLSVSEYRLYDTDTRISRDLIGPHGHMFQYVTWTHSGQSLIVVQNNNIYFKESVSEQRSGEPFLPVTSSGKVGDIFNGVPDWLYGEEVLRRDNTIWLSLNDQFLVYMEINDTGIPLIEMVHFSDPSNSYSEEQTLRYPKPGSPLPVLKLKVYNFPKNQTYVVSTPRLFLNRSPYVTSLVWKNNVTFAVTWLSVHHNVSIIGICSASSGFCYDNILLQSQIGWIDPVCLTPWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELV5</accession>
    <name>A0ABY7ELV5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AVIL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11289">
        <property type="entry name" value="gelsolin_S2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11293">
        <property type="entry name" value="gelsolin_S4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF57">
        <property type="entry name" value="VILLIN-LIKE PROTEIN QUAIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="31"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="147"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="224"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="440"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="490" mass="55059" checksum="02D62DA5E89C860C" modified="2025-10-08" version="1">MLTDKMTDPAFKVVNPRQPTFLIWRIEKLNVVAVPKQQYGNFFKGDSYIILSIKDVKGSLDAHIHFWLGKETSQDEAGVAAFKSVELDDLLGGFPVQHREVQGSESKLFLSYFKKGIKYNDGGVKSGFNHVDTTFKKRLMHIKGKHHVRVQEVDMAWSSFNSGDVFLLDLGQMIYVWNGKDSTRTERFKGLEQARMYRDERSKVNIVCVEEGDENKMAESEIKDSYIIDNGAAGIWAWIGKNSTKKEKSEAMRNALGFIKKKGLPNSTSVTRIIEGGEPSDFKSLFKSWPMPVATGKAYNNNKIAKTVQTKFDATTLHSNTALAAQTQMVDDGTGKCEIWRIDDFDMKPIRSQDIGLFYGGDCYVILYTYEVNGKENYIIYYWQVRVVMGKEPQHFMAMFDGKMIIFSGGHAGWTGGPSNEGPGDSYMLQVRGTSILNTKAIQVPMEAASLNSNDTFVVFLKTAVYIWCGKGSTGDEREAAKLVAKRSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELY2</accession>
    <name>A0ABY7ELY2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FGL2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF394">
        <property type="entry name" value="ANGIOPOIETIN-RELATED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="89"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="313" mass="35707" checksum="050FF893544CEDDC" modified="2025-10-08" version="1">MGSTNNIEGMPSMIHQPSKQWQEHFLVKCNIMLYPTVDGQWDIWSTWSTCSLPCGDGVETRNRSCSDPSPSHSGKPCPGPDVETQPCNLQQCIVAYDCSDVLKRGLPRGSGVYKITPWNTHKEVEVYCDMDTDGGGWTVFQRRFDGSVDFNRRFKEYEQGFGSLDGELWIGLDLLHSITSRANMNLRIDLSLPNGTTGFDEYSGFYISPPDQYIFNVDRRINSAGMSGSYLLSDISDHGHMNHQPFSTFDRDVDKWLSNNCARNYGAGWWYNYCTYSNLNARYNSDGYSGRFYYYSFSNTRLKTSTMMLRLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMM3</accession>
    <name>A0ABY7EMM3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045779715" evidence="1">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="64" mass="7042" checksum="D07F6DF7171FD772" modified="2025-10-08" version="1">MEMGFLALAVLLLSSATTRSCADPKQKYFPTVEEGCRRRTINGSSAIVCFCQADLCNQQDLEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EN95</accession>
    <name>A0ABY7EN95_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CDC6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_025645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="268"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6 C-terminal" evidence="9">
        <location>
            <begin position="500"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR11465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="601" mass="66944" checksum="40431C27205A4457" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EP23</accession>
    <name>A0ABY7EP23_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PIK1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_035783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001">
        <property type="entry name" value="OS01G0253100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001:SF931">
        <property type="entry name" value="OS11G0664100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="105"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR10707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="278" mass="31720" checksum="F49DE40A33E0BA7A" modified="2025-10-08" version="1">MDNVNKRVDMFEKLSREQNIPNEVVKLKTKTTNRPGKAVQRRISMFENMSDKQNIPTNGLKSQPKNEDEKTNKFIEECFADKTKCPFDGRLRRLNIKEIDHIIAFCDGVQIQKGRFADDLCGSVHYNSKSLPGLNIPVALKDIQTKNVDAKNSMKNEETAAILRHFAVVPTFAKYKSPDENRICFLSAFMINGDLEEVLKDDNVRAIRRESIILSQELRTKIMLQIAQGIAFLHSSTENKKGLLHLDIKSANIFLDSKFNARIGDFGNAREDTDRQEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQ38</accession>
    <name>A0ABY7EQ38_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13209" checksum="94F9D7F136C2A750" modified="2025-10-08" version="1">MNGRYKQLNRVYRGLFPTVDVYKASTGLPILGEAYNATESGDPKKREGCSHSGQGDRDECCETNGPHTKRCKYCQQQKSVTYLFAYNYKTNKFGFFPFEIPTYCSCKSSDCKQNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQE5</accession>
    <name>A0ABY7EQE5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">inx</name>
        <name evidence="10" type="ORF">MAR_025620</name>
        <name evidence="11" type="ORF">MAR_025650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR11440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR11470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="398" mass="47178" checksum="E7009E0E83C6F9C3" modified="2025-10-08" version="1" fragment="single">YFRVTSIVGGWTSWNKLRGNDDDDWVDRLSHIYTVVLLIIFALFTGGGQYAGDPIQCWCPAHFTGSYVAYTKSYCWIKNTYYLPMQDTIHPNNDTHHQNELTYYQWIPLILLFMAFLFKFPSFIWRMLAGYSGINMGKLVEMAGSTQVADQKKRNQTVEHICLYLDRWLEANRQYHYNIIVRMRQRASKFLFLCNKREGTFLTGLYLLIKALYVVNVICHFFLLNAFLGGFFEMWGFEAINSLANEAVTKESRRFPRVTLCDFKIRQLQNIQCVLPINLFNEKIFTFLWFWFVLVAVVTCASFLMWFWRTIFRRNRVTIVKKYLKINDNFQAGDKKLCKRFADQYLRDDGIFLLRIIERNTNDILMTDLVSKMWEIYRNKPMIRKELEGGEPNGDTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERU4</accession>
    <name>A0ABY7ERU4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YMD3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_036195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="699"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR11119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="737" mass="85288" checksum="958A5B37D4F2D881" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESS9</accession>
    <name>A0ABY7ESS9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">15-hydroxyprostaglandin dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="3">1.1.1.141</ecNumber>
            <ecNumber evidence="4">1.1.1.232</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eicosanoid/docosanoid dehydrogenase [NAD(+)]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Prostaglandin dehydrogenase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">MAR_026046</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">MELC-2E11</strain>
            <tissue evidence="23">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78836"/>
            <dbReference type="ChEBI" id="CHEBI:90697"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:48641"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.232"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:23261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90866"/>
            <dbReference type="ChEBI" id="CHEBI:90867"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48953"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NADH + H(+) = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:41596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78325"/>
            <dbReference type="ChEBI" id="CHEBI:78329"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:41597"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67026"/>
            <dbReference type="ChEBI" id="CHEBI:78311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41573"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>prostaglandin A1 + NAD(+) = 15-oxo-prostaglandin A1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41263"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57398"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:85072"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41264"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>prostaglandin E1 + NAD(+) = 15-oxoprostaglandin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16477"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57397"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16478"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57400"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="1.1.1.141"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:11877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>resolvin D1 + NAD(+) = 17-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132081"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:50129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>resolvin D1 + NAD(+) = 8-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50124"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132080"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50125"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>resolvin D2 + NAD(+) = 16-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137498"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:53589"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>resolvin D2 + NAD(+) = 7-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137497"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:53585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>resolvin E1 + NAD(+) = 18-oxo-resolvin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49244"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:91000"/>
            <dbReference type="ChEBI" id="CHEBI:91001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:49245"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 22">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.141" evidence="3"/>
    <dbReference type="EC" id="1.1.1.232" evidence="4"/>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd05323">
        <property type="entry name" value="ADH_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="WAR11866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="263" mass="27527" checksum="A1B4512D287FCCA5" modified="2025-10-08" version="1">MNITDKVALVTGGASGIGQGFVEALLAGGAKVSIVDYNEEAGRSTEKDLAEKYGSSNVIFCSCNVTSQEQFEEAFRRTREVLGGPDIVVNNAGVGGETDDKWEAVIDINLKGTLRGTRLALRYMSEAGAGSGGVIINMASMAGVNPNPFSPVYGASKAGIIHATRSLAISPDVQKSGIRLNVLCPAFVDTPMFRNMASGDASQTSGSNQAAVKAFVDHIGVMSVEEVAAAFLDLVKDETKNGIILRCAKKTGIQYSTLAVQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUZ9</accession>
    <name>A0ABY7EUZ9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="97" mass="11490" checksum="9C5B1D10A07A99B0" modified="2025-10-08" version="1">MITSTNDSLTFNYYTSTNDSLTFNYYTSTNDILTFNYYTSTNDILTFNYYTSTNDSLTFNYYTSTNDILTFNYYTSTNDILTFNYYTSTNDILTFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVF6</accession>
    <name>A0ABY7EVF6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="335" mass="37474" checksum="6A39BC488F468B25" modified="2025-10-08" version="1" fragment="single">GVRYNDFDLGFFGAYWFQSHLDLRYEFTYRHITNVAITSGLEKGGSKCDLQRMAAIIDDCRRAAYSTTTIIEMLVVTHHFRDDDTGEGYINGNYPSTASSSWGGLCDDINKSPTPHVHLKSNCLCNDWNDGVYMFHVKGVTNVARDWPFRTNRNCMPAVVPTDTCRALVPPGSLAFTQAVCSRTLVNNKATFTLNPNDDVCTSVSISGDDVTFHVYNHEKDYSGIYQPGYSDIYYLYDYDDGETVDFFVATEKIYDMASTKKIQAGDEVLVGLNLFPTICLDYGSGTFTEPEEAADENCVSNTIAIATLTTLLVLLLPMMGVVVMMFYKLHSRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVH2</accession>
    <name>A0ABY7EVH2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46043">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46043:SF13">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="407" mass="46822" checksum="1D97154B7BD309B6" modified="2025-10-08" version="1">MIIYVESKAFPYKSFVTVVQPGDKVARVRAQMLHILYEIGREQYQFRLRYNGQYMRDAFSLDEYNIEANAVIKMVPLSDDHKDALLYMHSLTLFLYVLTSYWYSVFWLAGYLLPFWYLIPGYTRIGGYIGNTFHRRLWFCVITGFMGLAVMAVAIFLAVSTWQEIVIGDVIERYLVQERDIEDVMKLARGSKVKDRRTAAYELATMAASSDDNKFRIVAEGGLSDLAHAARNGSMETQRLVSSIFLELEELLEILLDIPVRMMDKKLNLLAGKILLYFAENNQSRQWMLDMVHLKDYLMTFAQTRDPILQKVVVKVIFCMMDSKQLKDQARVRKLDKVLAFCMENSADRDVWDMADQGMQVINSNEDIFPTLPVLSTMEKLSMGQNSAFGSRASLRSSSSSQSSRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWE4</accession>
    <name>A0ABY7EWE4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endoglucanase</fullName>
            <ecNumber evidence="9">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_004373</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="9"/>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033126">
        <property type="entry name" value="Glyco_hydro_9_Asp/Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="Carbohydrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00698">
        <property type="entry name" value="GH9_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044975784" description="Endoglucanase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="10">
        <location>
            <begin position="118"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR14268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="550" mass="61410" checksum="8701988F7365B8BC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXE0</accession>
    <name>A0ABY7EXE0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTR1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_003859</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR13754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="477" mass="52903" checksum="08535B42C1DD7E69" modified="2025-10-08" version="1">MEQNGKLYVVQKTAPEGGGMTKWLFFSISVCVFGNSFLYGYNIGVVNSPALIIKTFYSQVYLARDGIETVFNPQDKGLHYVDPARYVNTTTPAVVVVDNNSNTTADNSTALSDNSTKGTYAVETTTVRPVSMAKTETEINEDNFIELLWSLTVALFVFFGMVGAFASGRVADYFGRKKGMIIITVLMFFAAMFACLVLFPLCPESPRYLLIKKADEDGAKKALVKLRGYDNVEEEMEEMRVEARRASSVEQFTLKKLLTTPELKLPIIIACTLQVAQQWSGINAAMSYSTFIFKQATIPENTIPYVIVGQGAVNVLATIVCVPLMEKLGRRPLLIFPMCGMDSKKILGIVCIVVMMTYIIGFAVGLGPIPFIVCGEIFRQEPRAAAMSLSLAFNWICNFILMLSFRFIQKAIESYTYLIFIVILVAAIIFIVIFVPETKNKTFDEIAQSIAFGRGARRPAFNENGGEELQPMGDQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZ68</accession>
    <name>A0ABY7EZ68_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CADN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_003898</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR13793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="191" mass="20874" checksum="270C9282EC55F22B" modified="2025-10-08" version="1" fragment="single">MSQIFTETIEFQDTYLSKFCSDDYPENYYSNYQNIISFLTFLNTSNSTGVNRLGKYLTGPPGASEPSRAAPGKNCACAICDNPPPQFGGKECEGSPASFEKCEMPGCLRVWFVSELCCYTINSRKLNILKRSHLDGGWTGWSNLTSCNSICGMGMQRTLRTCTAPAPANGGRECTGESMLSRECDNGPCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0B0</accession>
    <name>A0ABY7F0B0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="309" mass="35612" checksum="67C58BE57853667F" modified="2025-10-08" version="1">METRKLSSRKQYNQNHFWKLEWRMFGGRFMNFMCGYKNQRKTMSILRHWANVMIPNGKNLKVCRTNSSKLQKILLKSLRNNSAGILQANALKKKKKYAKEKLVEKGGGLTWKESKFAYAISVVLGYNYDIEKYLMTAEKCIRSICLCLSSLNGATYISDVNVNLEKGENYIPLKMQIQDIHNTRLIPQRTDKWFEVRKCAKVTGSTLYKALGLDGLKKQKEYFEHIKCNLPEQEVSEQAKLNMQHGTLNEENAVATIISKIMPIFTVELVFFEEGCVQVFDEDAQPFLVVFPDGSLRESESFESTKVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0U5</accession>
    <name>A0ABY7F0U5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_030389</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="3"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF43">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR15795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="344" mass="39284" checksum="AE019A6479801D86" modified="2025-10-08" version="1">MEFMNPEEERKLIVEYNTRFPMKVELHVHLDGSVRPETVLDIAKERDMLSSLPHKTVEELNRDVILVEPSSLDRLLQSFSYFMPIISGYKNAVSRIAYELCEDCAKHRIRYMEVRYCPQLFANSDVTNEYVGEPGTFTPRDVVVTVNEALARGMKDYDVTVKTILCCMTHKPDWAPEVLSLCKEFRDKGVVGIDLAGLEFQPGTPAEECALKKVFQEAAACGIHRTVHAGEIGTARAVREAIDEMKAERIGHGYHAYDDPEVYKKVINEHIHLETCPISSILTKACDSDVTKHPLRKSVKRLKSYIFNAARCCFSDVEERKSLVRQLKEVYGPKYDYQSIHPHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2P6</accession>
    <name>A0ABY7F2P6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="87" mass="10170" checksum="0E4476C5D2B18DF4" modified="2025-10-08" version="1">MSRGSFVRAKSPDDTGFIDKKAVRYEVPIHTDRRGTYTEWKFKCKDLRNEESKKYQCVVGMSGLDIRWVFAGCHVVSVRTRRILEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F538</accession>
    <name>A0ABY7F538_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">IDLC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_030750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the inner dynein arm light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019347">
        <property type="entry name" value="Axonemal_dynein_light_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183:SF0">
        <property type="entry name" value="AXONEMAL DYNEIN LIGHT INTERMEDIATE POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183">
        <property type="entry name" value="AXONEMAL INNER ARM DYNEIN LIGHT CHAIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10211">
        <property type="entry name" value="Ax_dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="178"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR16156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="257" mass="29333" checksum="A69E4AA16B8E565C" modified="2025-10-08" version="1">MIPPNVSLVKYDNPVLVSRNMDKKTPKARALKASPAPPTGSGPVPNPPGKQKLAPVDAKAAQQTDEILNSILPPREWTESGQLWVQQVSSTPATRLDVVNLQEELDRRLQQRQARETGICPVRRELYSQCFDELIRQVTINCAERGLLLLRVRDEIRMTIAAYQTLYESSVAFGMRKALQAEQGKADMEKRISELEDEKRELEKNVNELKAKCDQIEKRAQEQRQVEEKKHTEEIQFLKRTNQQLKTQLEGIIAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5C2</accession>
    <name>A0ABY7F5C2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_031984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045740410" description="EGF-like domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR17390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="333" mass="36525" checksum="464C0C149384DA19" modified="2025-10-08" version="1">MLMLILCAYLGTGDAVNDCAPCECCKPGSNCSYNDSFRIQNYCSGGCADGYGGPTCEHACASKNCITCSPDGTCDTCKDGFYGKSCRSKCIFRCQACKSSRSCTSCSNGYYEGTLETGCNHKCQPECRSCMNGSSCISCKSNQYFGSTCSTHCPSLCKHKTCSVNGTCVDCRNGFYGIACNDTCSPQCLNGECERITGHCLQCVDGYKLISGKCEASHCDYCREHLCDFDTKHCLRGCADGYRRDTNHSRCTVDTSRHSSHKEGDEMQKVVANKEIQKMKGALHYVTLVKGTDQHNYATLRTESGRQPETKYYSLEGHNSIEKTDNVYQSVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5Q7</accession>
    <name>A0ABY7F5Q7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NCOA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017426">
        <property type="entry name" value="Nuclear_rcpt_coactivator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10684">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10684:SF4">
        <property type="entry name" value="TAIMAN, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="896"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1240"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1383"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1422"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1649"/>
            <end position="1660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1660" mass="180167" checksum="FABFCE0CE1C500DF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F600</accession>
    <name>A0ABY7F600_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTPRV-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_031621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="102"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR17027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="166" mass="18835" checksum="EFA4CF0338F88AAD" modified="2025-10-08" version="1" fragment="single">AQYRTYYNEGQIKRESANPNPKSPRPPANKPTSVKQQVSTHEETAFENEIDLEKDDERNGALENSSRGDQTYYNELGSSTNKSKVHINQLVKYVDGKTHDAFSAEFEKFSRGLVKPYVESQKRENMSKNRYNGIYPYDDSRVRVTGSGGSDYINASFIDVCSYAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9B8</accession>
    <name>A0ABY7F9B8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GABR2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_031985</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="10">
        <location>
            <begin position="124"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR17391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="378" mass="43008" checksum="DD6787790BDD7DC5" modified="2025-10-08" version="1">MEEIEELATATGHTSNYVAAAMDQFHLIKPVTELDFLILNKNSANDVRVDVASFDPKNTHKAPSDMFTYQDRPVPASLVSFVAVIVMNTFGAAMSFAFLFFNIYYRNNSINMKHFRDTYIFYGKQMHLNKIIEKDNYSLQRNVIKDAHLFGLIGAFMSIDLVILIPWTIIHPMRKVEIVARSEYSTDNDVIWSVIYSYCHNQFEVYWIAVVYVYKGLLLAFGVFLAWETRQVTVPELNDSKYIGACIYNVVVMCVFGVPLSHVMPEEETTLLYVLGSCLIIFGTTVCQCIIFIPKTLRKPQHSKRLDIVSDVKLGVDLPAAPNATDTDNVKEENKLLRMRLASMTGNIHFYKSGTDYVLFKTDGASTSTEREQKKSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FB84</accession>
    <name>A0ABY7FB84_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SLA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR18051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050828">
        <property type="entry name" value="C-type_lectin/matrix_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45710">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45710:SF26">
        <property type="entry name" value="RH26557P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="86" mass="9586" checksum="2D2781B3487589EC" modified="2025-10-08" version="1" fragment="single">MPSNIFQTVGADSACMDGWLHNKDSCYLNGHTDLTFIDAQRYCQSLGANLVNLETQSENTFVKGYLSDLKDSKHWIGLTDQNVEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBF5</accession>
    <name>A0ABY7FBF5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TENX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_031225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR16631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="498" mass="54361" checksum="2E33849777BD0790" modified="2025-10-08" version="1" fragment="single">CSLNCSANCVGSSCGKSYGVCLDGCLEGFTANSCSDSCDGFCKTCSQTNSTHCTSCFGGFSGSDCKCIPNCRCELNNEVCNECTNGFEMKRKDCKCNKNYCLNSTHCTTCQNNKFYTYNGTCCECNTQCKNKQCSSEGHCLNGCEDGYSGVECADLCTYYDGNCTKCNQTEPFCVRCQPGFSPNTDGVCTSCSGCIDKACDTERGVCSIGCRPNFWTNTCEKECSSNCSVCDDVSGICNECTTNTVYGLFCNLTCSPNCIESQCNRTTGDCNNGCITNMYGQKCEYKCPESCEVSGENSKCDFEGQCLYNCKAGYQGRSCNIVDAKASKVSTAAVAGGVVGSLILTMAIFLLIVLTRRREKNKQRNSSQHVYVNVSDTSTSVLVKSDETVPHGPFVEMVNPNYKYSPKIEKKTQTQEKQSGEKRKLPGRQPAKSVTSVMLEIDANDACVRDFVNKHENNDAAYYNDANDNFPSGLTKSYHASHLKENVSKNRYRGIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBT9</accession>
    <name>A0ABY7FBT9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TENX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_000920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="529"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="549"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR19082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="572" mass="62786" checksum="3A3C6787C64E49C8" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCJ5</accession>
    <name>A0ABY7FCJ5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="61" mass="7129" checksum="0A9F2388B8ABC288" modified="2025-10-08" version="1">MKGVVSLDVLFLITQLRSLFKIIPTLWITVAILHRTRDKAGYKKHDSCAEFCFLFDTESRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDR5</accession>
    <name>A0ABY7FDR5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TNR16-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_002058</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052491">
        <property type="entry name" value="TNFRSF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46330">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00020">
        <property type="entry name" value="TNFR_c6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045583562" evidence="9">
        <location>
            <begin position="32"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="7">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="10">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="7">
        <location>
            <begin position="91"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="10">
        <location>
            <begin position="91"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR20220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="237" mass="27121" checksum="60CC3A907A4397EC" modified="2025-10-08" version="1">MQCQHTIINLLHLQNTLILSMSLLQSHYVIGVLPYPPYKIKAGYREESCQTGQYYQEDINGTGMCRKCFVCPKGYMEHSPCSKTTNRSCNPCDIGTTFSDKRGGICRNCTECKRGQFMRRQCLPYKDTRCRKCPKGTYYLDGESFGCKFCSVCQEHEDEISLCTPLQNRECRFKEAVYSNITNPSDSAQEYQTDFIFSTRLVLVSLLIVIACAFLIFLFATVLQTISSRFPRISLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEI8</accession>
    <name>A0ABY7FEI8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="157" mass="17328" checksum="D277E97DA023C2DE" modified="2025-10-08" version="1">MGQHAQHVTMIMGQHAQHVSRIMGQYEYAQHDNGTTRITCDQVNGTTRTPCNQDNGTTRTTCDQVNGTTRTPCDQDNGTTRTTCDQDNGTTRTPCDQDNGTTRTPYDQDNGTTRTTCDQDNGTIRTPCNQDNGTIRKPCGQDNGTMCPGEWDNTQTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FER8</accession>
    <name>A0ABY7FER8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="48245" checksum="49E287230A9D6B6B" modified="2025-10-08" version="1">MMNFFVEHNLPYLVADHLTELVKKGVSRFSDRPEIQLQEDQVNEALVPHFQQSVEKLCRENKFSIMIDESNDRGDNKLLAVLVCMHDDVVQRVKTRILTLRTVGAKNSMSHLATICVGKAVKSLPLPVEDLVDVYFYFQKSMKCKETLRSFQEFTDTEPSKILKHCQTRWLSLEHCVSGSSQIGVMDSEIHRLLCSLLADEGNRGCLRHHEGRLHQSPSSARVQQIAVGWRARQFLDEHDVAPYTTEKFFRSTVVKVMLAKFLFGDRKLKAMGYLNPAFRMNVTLSHVHFFGAAFLSKERGCLNALEREAGDYLVILWKELPMAKVPVINVSMEAFWSDMEKVTTTAGEHRLTTLCNLSKIILTLPHSNADIQRVFSIVRKIQTNSRDNLGQEAYQENILAVQLNNPRACHLYLPDLDTLKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFQ2</accession>
    <name>A0ABY7FFQ2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SVH2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_014969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="207" mass="23268" checksum="7C6F7EC3AA41D2C6" modified="2025-10-08" version="1">MNAKINFSSDRVGDHPNFIKFIGAVVDDVTMGPMIIYEFRENKTLRDYIEKNKSNMTVEMQENLFRFGLDIAKGMDYLTTKGVTHRRLAARNILLNHLNEVKIAGFGPQTAGEEDGRDAETGKKVRLRTPYTGKSRNLPQCLKRGEHLEKPGICDETIVGGTTPRNDPALRRSASNLTHSSSILQQTTSITTNANFIEKLYLFCVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIZ8</accession>
    <name>A0ABY7FIZ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PADC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_016127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702:SF1">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045622736" evidence="3">
        <location>
            <begin position="27"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="79"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR22153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="203" mass="22364" checksum="31C811B31EF95E47" modified="2025-10-08" version="1">MKPKISVKYLFTVLSLILDTLVSVVAEKKVLVTVPNIDVLLTDILFMEIIRPAEISYSYKIRPAKNFGVPFIQKYSMVDLIAAKPYHGCSPLTNAHFLSGKVVLLQRGECSFVTKTLNAEAAGALAVVIADNDISNDVSFVDMVDDNTEREVHIPSMFMLGKNGHIIKTTLERLGIQSAKINIPVNATGSPTHIVSQPPWTLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPQ6</accession>
    <name>A0ABY7FPQ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IFT25-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033558">
        <property type="entry name" value="IFT25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33906">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33906:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="112" mass="12351" checksum="CF93106C553CD2EC" modified="2025-10-08" version="1">MYGRDGGANIILATSNDQLHPPENMLDGSDATFWSSTGLFPQEFIISFGNTMDVQRVSLSGYNNLPQTDGQLQNEDIDVRAKATHLRFVIDSGYDHFIAIHQLNVNGNTVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQS4</accession>
    <name>A0ABY7FQS4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR23078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9296" checksum="3314633E15CDF16C" modified="2025-10-08" version="1">MLENDIWTNIKNKLNVKTSVDGDFSSQNDNICEECVICFEEKEFVTIVPCLHRETIGNINKEVSHSVLIELAFALTTAIRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FR32</accession>
    <name>A0ABY7FR32_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RAB28-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="151" mass="16867" checksum="A22D1AC3BF537675" modified="2025-10-08" version="1">MSDSEEETPDKQLKIVIMGDGASGKTSLASRYSQEQFGKQYKQTIGNVNVALQGALLVYDITNHNSFDNLEDWYGSIKKVIGSQRMPHIALVSICFQKIAAEILGIKLTKPDIEQHHRVVKAEIVNYSKQEESAARHLPQTQTKSSFCSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FR79</accession>
    <name>A0ABY7FR79_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TENM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_037070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46901">
        <property type="entry name" value="GH04942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46901:SF2">
        <property type="entry name" value="GH04942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046919615" evidence="2">
        <location>
            <begin position="21"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR23401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="300" mass="32408" checksum="D6DE07FCA1EFECC1" modified="2025-10-08" version="1">MVVNTLATVCITSMVVNTLATVCITSTVVNTLATVCITSMVVNTLATVCITSMVVNTLATVCITSTVVNTLATVCITSMVVNTLATVCITSTVVNTLATVCITSTVVNTLATVCITSMVVNTLATVCITSMVVNTLATVCITSTVVNTLATVCITHFHGCKYTRHCLYHSLPWLRLSHAVVVPNIECRNCSLQLLRRAGEWLTNCNGGQYDFYTCADVNIVQANPGNVPMCSSHGIMRNASCTCDHLWTGNKCQYKEECMSDSDCQNEGRCKIGMSTRYPKNHCYCKQGYFGRRCEKGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRF5</accession>
    <name>A0ABY7FRF5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NRT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_038284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="107"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="457" mass="51791" checksum="53E8450EE40677FC" modified="2025-10-08" version="1" fragment="single">DQSLLKRQRPIRRVRPLKWTSVEYVEFITSLQEHIRSEEFPMPVLQLAICVEDHHSRLTAPTKTAGADALTLENLAARVCRETPFHCQHDDWKRELALFEHIGYAPTEQLARDHDVVYVSINYRLNAFGFMWLDMLRVGSHTNTSGNYGFMDMLTGLHWMQNNIRQFGGDPNQVTSSDGTAIYALLASPLGRGLFHKAWTISGSPVMNKTAAEADADNQVFVHNTGCQDADCLYTLTPEHVLASVPWEEFPYWAMSDLTGIPAKDRFNDALPVVDGTTSHEVSLESSPQAVTNWTWKDNKYQAYLYLENVHTPEFQLASLVTDLRVTCGSEYLALVMATSFTSPVFRYIAEYAPSAPMKAFWVTLPARYAFHGIDAFYKTLGLMIDNKTDADRQWEVNVQQKILSFMRNGSPFTADWGMFPGQTAVLSQNTTVTAGYHTAECLFWLKNGFFSYSWIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSS9</accession>
    <name>A0ABY7FSS9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_037858</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="177"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR24189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="388" mass="45220" checksum="B9C3FF2E44A6A472" modified="2025-10-08" version="1">MAEFDLTTRMGQYLDRHLVFPLLEFLSVKELYDEKEMLKGKLDLLSNTNMVDFAMDVHKTLYPDQEVPATFIAKRTNVFKEAMVDTLYNYAKFQYECGNYSAAAEYLYFVRILLPPNDRNYLNALWGKLASEILMQNWETALEDLNRLKEVIEANTFGSALLSLQQRTWLIHWSLFVFFNHPKGRDLIIDMFLYSQLYLNAIQTMCPHILRYLTTAVITNKSRRRTVLKDLVKVIQQDPITEFVECLYVHFDFDGAQKKLRECENVLVNDFFLVACLDDFIENARLLIFETFCRIHECISINMLASKLNMTPEDAERWIVNLIRNARLDAKIDSKLGHVVMGTQAVSPYQQVIEKTKNLAFRSQVLAMNIEKKINAKSTEVPQWGAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FU34</accession>
    <name>A0ABY7FU34_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_011432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR25728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="81" mass="9221" checksum="03BAC75012FFD954" modified="2025-10-08" version="1">MPVSFLLPPSGSISSLDLLDGPDIHDDLEEICDVIDAMTYCDEREIPIDGLDDIDEIKERIKLHFIKQNSMFHYDIGLTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUS1</accession>
    <name>A0ABY7FUS1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SUEL-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd22823">
        <property type="entry name" value="Gal_Rha_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="50523" checksum="A59C2BB3794A7EE0" modified="2025-10-08" version="1">MNLKGFVHKYITIFSGTFALGTLYKSTASCYGVISPASNFMFSTCPPGEVIAIKDITVAYKAAALNCTFDNVQDQFQLCCSNITEQDCQMSYNFHPNNAVQYIEKCNGRSSCNVMATVVLPQDCIGVPDHYPNYMHINYYCIPETSILSIMSGTITSLGQSVYLQSPGFNYGQKIPSGKTLTCSVYTCDMGSTLSITPWQIVMENKWGQCQQRLIVKRPDGNTIDSWNCQDNTASPRTLQISEQSLTIQLENSLASDSGSFWLGFAGSSPDGRVTVSCPPETNPCAGVSPTINSISTLMTTTTIATTTMDSTTTPMTPTTRTTTTTRTTTDSISTPIVTTTTTPITATTSISTTAGQSSTSNITTENLISTIYEETFSNSKTTLGSIQFDTSTIPEEEGLRKAIIGIVYPTPTPTEFQIQITHHQFQHTFLVDLAVAQAKGPTSFLSETATFSDGYIKVMDLFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUX1</accession>
    <name>A0ABY7FUX1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IF44L-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_011646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR25942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="231" mass="25720" checksum="7ACC1550CAC41E79" modified="2025-10-08" version="1">MGNKNSSQRHPPSAPPPQVLKKLEAWRLTVKPTFEELISVKCGPEDIFGNIRILDTMGFTGAFGKDETGITEDDIKAVCEGRVKSGHTFNKGEAATAECNKNKPHCIAFVVSAEAVQDLTDNPDSMTRDKFLKLRDLVPDDIALIAIITKCDRICDDTNTDIENIYKSKTIENLVKRTEATFGMPQNKIFPIVNYVTESFPNEKKSLPILWAVYSAIDFAHDRKSMGVVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXP2</accession>
    <name>A0ABY7FXP2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR23921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="112" mass="12669" checksum="E9308F45762BACF2" modified="2025-10-08" version="1" fragment="single">EQPDTHQGLTFPQGTTRYTSSLCSLKEQPDTHQGLTFPQGTTRYTSSRCSLKEQPDTHQGLTFPQGTTRNNQIHIRAPFPQGTTRYTSRLLFLQGTTRYTSGLRSLKEQSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYV7</accession>
    <name>A0ABY7FYV7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metalloendopeptidase</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_013097</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="12">
        <location>
            <begin position="119"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="11">
        <location>
            <begin position="339"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR27393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="385" mass="44308" checksum="FEF326A468968310" modified="2025-10-08" version="1">MASTSHQESIRTFIMSIMIAPTDINRQLKGFYVVLSDESKAKQLMNNNLAPQKEGGSIRKEAHETKVMYVCGLAAGQLMMEELQEFNIDPLNLNGTEPENIPRQRRSKSGRKLERHRRKAIRDVVLRWDDGVIPYTFVNGHFSEKEKYMIRTAMTEWEKYTCLRFRPSGRGDRNLVRFQNGLGCNSQLGMVGGSQPLNLDKNGCRFKGLYLHEIGHAIGLVHEHQLPNRDEYIEILYQNVEPSMRIWFNKYSSQEVDQMKVPYEYSSVMHYGITTIRSKQTDKEKNIGRVYRKELSFTDCDSSIVCRNGGYIDQNCKCICPDGTDACTKDKDEPQDRTCFNAHGDDWQCAIWANQGECDRNPRYMTESCKRACKLCGDKSKDDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYV8</accession>
    <name>A0ABY7FYV8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="231" mass="25538" checksum="95B425756DFCDBD2" modified="2025-10-08" version="1" fragment="single">MYKDISKDRMSTTEKDYTDLAIRETDHVYIDVSQDRMSSQERDYTDLGNRGTEHMYGNISKDEKNAPENNYTDLTARGTEHMYGDISKDGIIVPENDYTNLGNRKAEHIYGSLNKHVVNDEAKPGSGAFLTAKIRLIAFVSIFVMCSVTSVVVIVLLTQNSGEESTISTQSTSDYITGTTNDMETTTNLNKKTLSATQFLAPNTTNEVTTGQLPAKTTELTTPPTPTAIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZE2</accession>
    <name>A0ABY7FZE2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TCTP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_013284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TCTP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR27580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="100" mass="11254" checksum="A2C91DA12D0515DE" modified="2025-10-08" version="1">MIVFKDRITGDELFSDSFKMSEVFDGLMYKVHCCMTVKSGDALDPSAFGLNPSAEEQEEQVDDCGQEKGLDICLFHKVEECPAIDSKKSVSSYLKKYLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G284</accession>
    <name>A0ABY7G284_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Y045-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_013208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR27504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="379" mass="42447" checksum="AA70BEB71DBF6A85" modified="2025-10-08" version="1" fragment="single">MEELVYKAICDDRPARLESFLRNGGDPNTWIEDSARISTKSFLHVLLENGAQVDIQGSWGQSPLMLCILVEYFDIAELLINNNPSIINQQDSSGNTCLHIAIGNDSVEGVELLLRYHADMNIMNMIGISPLMKICTMKESKNMHKIVELFIQAGVDIDLKDFKSNRTALQGAVLSKNISTVELLLNAGADPNSQDRSGRNALSNLIMSNLRLYEQTHIIDDHLMTIIHLLVMSGTDLDTCRYEGSSPLVMAIQFRCTPLVNYLLVNGASINGKCTMDKYNYDLLFDCFEWAILTGCVDIALLLVQAGYNASAIDYITNYSIMPPQCLQERPEILDELRMMASQPPSLFDVAVRRIRRSLRSNIVSRADQLPLPKLLIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3C0</accession>
    <name>A0ABY7G3C0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR28930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12318" checksum="928212046D9F74EA" modified="2025-10-08" version="1">MMLMMMMMMIGKGQTDRRIDLSKAIYFSNWGVVIRLIGLLHSSISAFLVLKGGDIENDDIKKRAIGSVERFTNSTFQTLKEQNSLLQENLRLQQELINRQQRAGGTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3W2</accession>
    <name>A0ABY7G3W2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="207" mass="23078" checksum="75CAC5376B56EE6D" modified="2025-10-08" version="1">MFTTEQAMITTELAMIPVKLTMITVELAVIPVELTISPVEPTMINDKLTMVTSEVTNITTELTIITTELTMITMELTMITTELTMITMELIIITTEQTIITVKLRMINIKLTMITTEQTIINTEQTKIATGLTMIAVEITLFTAELTMITIELKIITVEVTMVNAVLPMITTELATITIKLTMITIELTLITIELTMITIELTMITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4W8</accession>
    <name>A0ABY7G4W8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="239" mass="27122" checksum="068A8C39F9F86917" modified="2025-10-08" version="1">MSNLNELFTELKLLNTSVQIASNLEHQPLSQRKPKLKIAQPLLALDETRRYRCELLKTNTTILKSVIESVPCFGEGKYVLYEFKKMLAGKFADIVENTEVLVRAIQRLMDTVLGPDALNADDDGKCEANTEVLQKSKTGTAPTLTILKGDVNCAYITRDDVTIKCYGDCNMVYIIQLLAVNYVFDIDYPRPIAMFLGFLQQFIFNLIICKAVLGYTPYVKIMSFPNLHLIIHHESFKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7G6</accession>
    <name>A0ABY7G7G6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="145" mass="16933" checksum="A50142EC4BFFDD46" modified="2025-10-08" version="1">MAPLLRNSRVLLYVVTGQSHGQDSVGDNNQAKKLFLLSDFDNNTVLTVDEFDHVFRDFDNNKGLELFLNLDVNKDFVIDPQDVAFIFSWFDTDYFYNQLFRIRVQSKGTQVSDRKLDKVTKLLTVLLFLKSAVNWHFKRYEVAIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7R0</accession>
    <name>A0ABY7G7R0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="163" mass="17867" checksum="5DD177D06DBC5C78" modified="2025-10-08" version="1">MGVFKPPSLTTPPVSLPTDPDTRHPFRTSTGSQATDSNQEITPLASTTPFPLLTCSTLILVLQYSVYAYVELWARVSDCGALRVVGSSTSVVLRYYGMSRIGVVGSFSNALFTLFRRMLCVVTNAILLILQTVEILSVAPVYRQPRVSDSVRNARIRRGSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7T7</accession>
    <name>A0ABY7G7T7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="91" mass="10605" checksum="C5BFBDC9B0DD0726" modified="2025-10-08" version="1">MSKTCCINTHGRFANQPAIVSCLADHLKASPLRKENKNQGGKNVVTIRQFQRHNKSSTLRPSMCRRNAIYLWRRKQLRWIGMRENVSDKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G810</accession>
    <name>A0ABY7G810_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="231" mass="24949" checksum="0FEC6D54133D46BC" modified="2025-10-08" version="1">MQSNLEGPQGQIEKLGKGEGGLKLTTSSTNNSEARPGPVSEAHSTVCALRSIKTRVTLLLAHRPKLVRRCAARDLAILRRREGLTGYRWNLPNPGGPKVLDTPPDVGTVIIVLEKSYYPEYPNILQTTEASEEFQLSSQTVPHSLKAKTSTLPSYALFPPTSLADVDPVGGVDRGILAVVVVVPCAYSSIFRMATVVFTPALERTILDKGLGPLTFKIVHPYRPSASSDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9G9</accession>
    <name>A0ABY7G9G9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="73" mass="8785" checksum="115701E87BE52F28" modified="2025-10-08" version="1">MQLRKGALAKDALRCEIFEFTCCNKKKPAIMRRLPFNIRNVALPDMNLWAKFKTDFRHKDYFCQQQSRQTFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9K0</accession>
    <name>A0ABY7G9K0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ING2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_003677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="607"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR30109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="668" mass="75470" checksum="711FB58173714749" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GA93</accession>
    <name>A0ABY7GA93_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046329959" evidence="1">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="61" mass="6982" checksum="8CC86693E47F11CD" modified="2025-10-08" version="1">MFVSFVDVCFLVAFSATSLKTLNAIPLLFINDLEETLITNGHDSIANDRMECYDVFEQYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBE9</accession>
    <name>A0ABY7GBE9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NCS1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_033226</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF198">
        <property type="entry name" value="NEURONAL CALCIUM SENSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR30684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="220" mass="25780" checksum="8867ED6A7A16E46E" modified="2025-10-08" version="1">MNCRIMPLHGRKSRTKITIKLYIFNMFMMKFEHITICTFSISSMTPITNMYLILIQRYKGFMKDCPDGKLTLEGFTKIYKQFFPFGDPSRFATFVFNVFDKNKDGYIEFHEFLQALSVTSRGNVEEKLQWAFRLYDLDSDGFITRDELRDIVDSIYKMVGNTVKLPEEENTPDKRVNKIFDVMDKNHDDKLSFEEFLDGSKKDPTIIQALTLYDGSHATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBZ3</accession>
    <name>A0ABY7GBZ3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_033300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF25">
        <property type="entry name" value="PROTEIN LIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30278" checksum="6AAB69009AC722EB" modified="2025-10-08" version="1">MVYWSYFEFANLPTLTKMTKMFSEDEGDKEWYIQDITIVEERFMVASDWGSDCLRCFDLDIVSQSAQMSFQRRINGGDGCLGIVYSDNKLIVSYDDPHGKVQVLDMDGDILKVFEKNDNGEQLFTKPWGLAVSPDNSTIYVSDRVMGTVTALSQDGRVLSVLKNHDNLRYPTGATIDNAGRMYVCSMWTKTVCMVSQETGTVTKLLGEENGLSYPTSIAHFPVSYGNVFLPNRTQSKLKDVVEFLHNLVTSVRFRLKIVVLELMAAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GC94</accession>
    <name>A0ABY7GC94_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NEK6-subfamily protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_033671</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.34" evidence="5"/>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289:SF6">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEKL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR31129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="339" mass="39152" checksum="1290585E098A97AA" modified="2025-10-08" version="1">MADMMEADAGDQSEGSSIYGTLSAFNIDKKIGKGQFSEVYRVICKATGDVLALKKVQIFEMMDAKARQDCKKEIDLLKVLNHPNVIKYLESFIEDNELNIVLELADAGDLSRMIKHFKRQTRLIPEKTIWKYFIQICSALNHMHSRRIMHRDIKPANVFITAQGVVKLGDLGLGRFFSSKTTAAHSLDKCDYPPLPSDVYSEQLRKLVAMCINPIPEHRPDISYAYHVAQEMHAHFQGQAQQLLQQQQQQQQQQQLQHQQQQQQFQQLTPEQQQQLLAQQGNIQIVSAQQLTPQQQQMLLQQQQLQQQLQQQQQYQQQQALLQQQMMQQQAPTEQKQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GFK4</accession>
    <name>A0ABY7GFK4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S13A5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_034423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR31881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="489" mass="53571" checksum="128908DB3B01D420" modified="2025-10-08" version="1">MTLHLSDNIIAKDITMLLLGVLLIAMALEETRLHTRISLLVFGAMVITWFLSFWINNTSATAMMIPIILAVCEPVKEVRAQSAEEEAVLQMIRWRSPSIKCTKRTTTTKPAQDEKVFTNKHAENEFKALAKALCLSVAYGAYTGGMATITGTPPNLVLGNGQNESPISFTSWIVFALPLSFVTMIIGWLWLAFRFLVSSCFRRMDPEAKVAIDGVIRKRAKALGLLSFAETEVLVMFASMVMFWLFRNPPNIDGWGKIFIDEDFGIRIHTLYFSEHPFVNIASEKTYHSVLGNSVLYADPKMANGNKTAWGVSMMGGGFAMPRANQAFGQSEPIVLNVIILVVVGMVTEVMSNPATAQLFIPILRDMPLTVGINPLYLMKTTAIACSFAFMLPLAAPGTAPVFATGYLSIPDMALAGLPMKIIGIGVSMLAINTWGTKLFELDKLQDFLQDGTMVGTQMNSSLATTASDWLMGNETSPNIDSAHNVTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D7Y6</accession>
    <name>A0ABY7D7Y6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10229">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ93787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="553" mass="62639" checksum="E5F4715E93D086CC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D9G2</accession>
    <name>A0ABY7D9G2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35378:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35378">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="229" mass="26428" checksum="3BF54D5A3D00F7DB" modified="2025-10-08" version="1">MSLNLRPSEIHFSQDTIFNRFRNTQNIGNVLDNIFERRLQVDDLPRITVARHDGRWFSADNRRLWIFKKLQKLGRCSSIEVIEISEIPSNKMTTKNEGISVEIIGGDIEADNRRLCIFKKLHKLGRCRRIEVTEISEIPFNKMTTKDKGRTIEIVDDLPCIAVADHDGRWFSADNRRLWIFRKLNQLGRCRHIKVIVISAIPSNKMTTTNRGISVEIVGGDIEGVMGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAS0</accession>
    <name>A0ABY7DAS0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PR40A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_006890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25432">
        <property type="entry name" value="FF_PRPF40A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="4">
        <location>
            <begin position="160"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="4">
        <location>
            <begin position="277"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="4">
        <location>
            <begin position="392"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="4">
        <location>
            <begin position="463"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="208"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="328"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ94419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="608" mass="70401" checksum="8C6A4A29B58014D3" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBT1</accession>
    <name>A0ABY7DBT1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="164" mass="18561" checksum="DB530B522709C715" modified="2025-10-08" version="1" fragment="single">APLKANVWLEKLWGLHSKQELTKEDFVSWSAYHASIQLDETAPSTVEAHMPLFLEFAHSDTIIKHLMNVVKAATEYLDTVQNPVLVMDQPLFAIAQSIGEAGENLSNFTDLCGKMTAEQPQFKYCSAVVKTELYPRINHDRKFSELPHAMVIAWVFSFDHINDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCB1</accession>
    <name>A0ABY7DCB1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_007394</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="4">
        <location>
            <begin position="36"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ94923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="166" mass="18445" checksum="75413CB46BE31D6B" modified="2025-10-08" version="1">MPGIATFLCNLKGQRNPSVAIFEATVDSLNETVERVTTTINKSLLGRISKAVLISPMGTSSILIDGSEWTKDVHKPLKSNAITSTHFWGEGTAGRWTLSLNGRFHNVKDDSVSLTFTGIFVTPKEDKEEENTRDSDFMFISIALTLAVLLLVHAVIWRDYLYANRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCM7</accession>
    <name>A0ABY7DCM7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZBED1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_006561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47611:SF3">
        <property type="entry name" value="HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47611">
        <property type="entry name" value="HAT DIMERISATION DOMAIN, C-TERMINAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="193"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ94090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="250" mass="27945" checksum="337ED7746D08E879" modified="2025-10-08" version="1">MPTVSVIIPLIQQVQKVMAYNEDDGQTVRSIKEAVLKDIEKRYTSEELWHFLEECTVLDPRFKTKLAPETLGETYQRLSVLLSSGGVRVKVKGGQETTPVLQQETPQLPHLPLLSDIDQPSASSDNPDLEVDTDTDSTEKKVGLAAIFDDVVVVKAEKGSKSIYERVDKEISKYKMVQPIKIEMDPLEHCFYYPLLANLVKARLCIPATSVPSERVFSTAGDIVTAQRSCLASDLVDMLLFCKKNCHKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DF64</accession>
    <name>A0ABY7DF64_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="106" mass="12117" checksum="E4799DFF33DA9AB0" modified="2025-10-08" version="1">MSDGESNEPECIPVVVKVMFLRAVMILHIILSTWRVVIVMQNSAYWVLVLLCVFVLIEDGFEILKYYVKTSKCNGPSKKNKRAKSTVGNNYTTSKPKLVLFWGFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFP6</accession>
    <name>A0ABY7DFP6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroperoxy icosatetraenoate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.152</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Hydroperoxy icosatetraenoate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MAR_027860</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">MELC-2E11</strain>
            <tissue evidence="19">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:48636"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:48637"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.152" evidence="4"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF47">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 17" id="KW-0349">Heme</keyword>
    <keyword evidence="12 17" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WAQ95170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="390" mass="44670" checksum="91321CBC55797F4C" modified="2025-10-08" version="1">MELPDSLTITWTLVALFASLFCWYLYRHFTQLRRRGIPGPTPWPLFGNLLHQFIKGFEKTDAEWLNKYGQIVGFYNGYQPAVLVTDPELLKMVLVKNFPNFSNRPVPKNIPQLLANGIFFMKGRKWKKTRNILTPTFSAAKLKYVSNRLKCKEASIPFLGDAFSRLGLSSSPSKSLDFYEQTGQALIDERKKQKMPRVDFIELLMNAELDASRMEYVHNGVEMGNGAHTANGELKEKLTDYEVNAQAFTFFLAGFETTASLLRYATYMLALRPDIDEKLCNEISENIGEDIPTYDNIGTLKYMDQFISETLRFAPEKKSSYPSEGVTFLPWGLGPRHCIGMRLAQVEAKVALVHLLRNFRFEKCDQTQLGIAVIQHVKHSWKEALLKINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHQ9</accession>
    <name>A0ABY7DHQ9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="120" mass="12653" checksum="375AA889D5613653" modified="2025-10-08" version="1">MSPASMQLPTMNNWDMGPQHSPYNNMNTSSGPPYSSGNFTGGQSGGPGTPGSYPQNVPSPQNGSFNMLPMSPMNNTMANLTMNSGGDMMNKGMNPSSQVKVNTHSHHPPTPHSSVTQTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DI56</accession>
    <name>A0ABY7DI56_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Claudin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_029689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ96999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="40802" checksum="2B9C6BF136E541EA" modified="2025-10-08" version="1">MSSANVGLPVLISPMKDPYGESSRLKGALACSHRPPGSQLGVGQFREYIAQSGSQHGEIPVRKCVPYLVTIQEYGQSATMGRSWKLCRFSVAVLVVVVLAQLAAVAAPGWLIAVEGNHETHIGLFYKVRCETLNENRCQTISFRDEYFRDTRRKAELGRKTIAALDYNYNVAVWRQVLLTSAVGCSLVALLVQLGRRVVDKRHVRIIILSIALTALSAGLMLSVTSSYIVDCMYQMELLSFDTPRDHTYLAFPYSIALALGSVLLQFIGILVLGAHIFEPKVTIVKKPRRMSISTVEPGYTEKKMQPPPPAVKASEQNIPPAAMMTTATSAPKAPTKVESTPLMKTTVNVTSSRINPPQRKGDTSNILSEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJ39</accession>
    <name>A0ABY7DJ39_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HP1B3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_029908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="2">
        <location>
            <begin position="308"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="621" mass="69108" checksum="CC723D343386E18C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNV6</accession>
    <name>A0ABY7DNV6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Shieldin complex subunit 2 first OB fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049507">
        <property type="entry name" value="SHLD2_OB1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21669">
        <property type="entry name" value="SHLD2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shieldin complex subunit 2 first OB fold" evidence="1">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="109" mass="12303" checksum="E410CF1B1CAFE416" modified="2025-10-08" version="1">MPHQRCRCYFSLQDSVATTVMVNDKEVNVRTITVEDRTGKVKVSLWRNIAAEPVVLGDVVAITNIVVNSKRYNNEESLSSTQFTKIELEPDKTMTLSQQEASLVVERTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQE1</accession>
    <name>A0ABY7DQE1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="76" mass="8427" checksum="CB5DA20A794FFE6A" modified="2025-10-08" version="1" fragment="single">MCVTVKSPSHTANDYLATCVIQTFRRSTTTSDFEPENAMKNKSATLVRHSPLDQFAIVIRPSTSDPAINCKRQAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DST9</accession>
    <name>A0ABY7DST9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FRMD5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_025142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF32">
        <property type="entry name" value="FI22325P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="FERM adjacent" evidence="4">
        <location>
            <begin position="73"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR00770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="598" mass="67615" checksum="EE76A2185E4023DB" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSV4</accession>
    <name>A0ABY7DSV4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NCBP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_025157</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="8">
        <location>
            <begin position="9"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="593"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR00785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="780" mass="90642" checksum="2676674C529EEBE5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSZ5</accession>
    <name>A0ABY7DSZ5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_024344</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd23439">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF134">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 11" id="KW-0430">Lectin</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="12">
        <location>
            <begin position="479"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAQ99971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="619" mass="70899" checksum="E96B621C936D1D7B" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTP4</accession>
    <name>A0ABY7DTP4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRAM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR01068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="497" mass="56352" checksum="549AF8CFA439D6D7" modified="2025-10-08" version="1" fragment="single">FLHVHRKLDDCLICQRVDDCPICKCVDDCLICQRVDDCPICKCVDDCLICQRVDDCPICKYVDDCLICQRVDDCPICQREDDCPICQHVDDCPICQRVDDCPVCQHVDDCPICQRVDDCPICQRVDDCPICQHVDDCPICQRVDDCPMIALCVDDCPICQRVDDCPICQRVDDCPICQRVDDCPICQRVDDCPICQRADNCPICQRMIALYVNVLKIALCVDDCPICQRVDDCPICQCVDDCPICQHVDDCPICQRADDCPICQRVDDCPICQHDCPICQRVDDCPICQRVDECPICQRVDDCPICQHVDDCPICKCVDDCPICQRVDDCPICQRVDDCPICQHVDDYPICQHVNDCPICQHVDDCPICKCVDDCPICQCVDDYPICQRVDDCPICKCVDDCPICQPVDDCPICQRVDDCPICQRMIALYVNVLMIALCVDDCPICQRVDDCPICQLVDDCPICQRVDDCPICQRVDDCPICQRVDDCPICQRVDDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DV38</accession>
    <name>A0ABY7DV38_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YHU2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39414">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39414:SF1">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="836"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1600" mass="182950" checksum="53D1B1931C5A1935" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DV87</accession>
    <name>A0ABY7DV87_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_025139</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="5"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057304">
        <property type="entry name" value="PDE8-like_REC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23198">
        <property type="entry name" value="PDE8A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="58"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="8">
        <location>
            <begin position="242"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="708"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="728"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR00767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="746" mass="83990" checksum="5F48D03A52A7A98A" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVZ2</accession>
    <name>A0ABY7DVZ2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZFR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_025220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006561">
        <property type="entry name" value="DZF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049402">
        <property type="entry name" value="DZF_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049401">
        <property type="entry name" value="DZF_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762">
        <property type="entry name" value="ZINC FINGER RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762:SF3">
        <property type="entry name" value="ZINC-FINGER PROTEIN AT 72D, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20965">
        <property type="entry name" value="DZF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07528">
        <property type="entry name" value="DZF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00572">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51703">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DZF" evidence="5">
        <location>
            <begin position="512"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="577"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="902"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="577"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="923"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR00848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="940" mass="102799" checksum="741418DB6E486288" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DW36</accession>
    <name>A0ABY7DW36_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">B3GLT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_008498</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="10">
        <location>
            <begin position="110"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR01940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="246" mass="28318" checksum="96C03B23B8259F2A" modified="2025-10-08" version="1">MKSREAEDKPTVLKSDPKVSKWIFICEEETRIDLDKFEKFIQQYDPAKGEPINDDDLFIAVKTCEQFHTERVPVVLDTWAKESKNIEFYSETVDDSIPTIDLGVPNTERERLKRLLACYDPTGLIAIGERYGYRSALGDGYDYITGGGGMPMVEKLVEGCKCPQDDSPDDMIIGMCLKRFNIPITHVPYLHQARPDDYSEGYLSRQIPVSFHKHWNNDPRAVYRLLKSYDKQEQEGSVQTDKHTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWS2</accession>
    <name>A0ABY7DWS2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047391090" evidence="1">
        <location>
            <begin position="22"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="296" mass="29880" checksum="70F313456368AB78" modified="2025-10-08" version="1">MIRWSLLVFGCVLVFRHRVETAVGGTTCSLGGNECSGIANSFCDVPNLVCKCVDIATEDTGASTCPLTVCSSDPTLCTDANSECLSSTACACKTLYELSGGDNANACTAKGQVCDTTLTSPVCACDNGYTATAGACVANVVGGTCAASGYECSALSGGYCKTGTGCACSAIYDLSGTSCTAKRVGVTCTSSGGECQYILAGYCDTTTNANAPVCACAAIADIASQTCNFKACTADAFCTAIDPNSECIKGNCLCKSGYDINGSGTSNKCEQQSGSEAITASFVMVMACLVISFLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DX02</accession>
    <name>A0ABY7DX02_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_008553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="32299" checksum="C43A9266D34BDCD5" modified="2025-10-08" version="1">MTFYTNSEYIIVFASKSDRNRTKGYTVVPGVISPPDCDKYIDKYKEWLKQFKGSALWQKWSKGIIRGYGTGFLESTWEVRLQAKEVFSQLWKTEKLLTSFDTIAAGQPPEEGKEPFDDGSSHWLHLDQESKKDGLHVYQGGVYLKEACHDDWTLQVMENSHNVFEKFLRENPKAAQVSIEKKFFKLNKTQVKYFQKNGCKIVRVPMPKGGLVLWDSRLVHDNAQPLEGRENPGRWRYVVFVSMTPAKWASLADMDLKRDAFTGITGQVQKPIRGKSLDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZW6</accession>
    <name>A0ABY7DZW6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_008257</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd22918">
        <property type="entry name" value="HFD_TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="8">
        <location>
            <begin position="152"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR01699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="358" mass="40042" checksum="CDB053DB8A95B54F" modified="2025-10-08" version="1">MADTVFFKMLYIYSGVCNAVKMAMVDNQLVNHVFLCVALDLLQTTLNVRVGWPVKCCVGPPSCPGLVQSEQCQAPPGSLKGEDIHLMRYMPADWRARHCSRVCGNPSITQPFFTQSNSFIRSPMIVIHNSHINQELYWIFSVFREDTMDALSKSRRKALKVAVGALCTEVGYGMAEESAIETLTEMLQSELCGRTEVMVTDVLMSLVDQGINIESIPAYANRLNKSVLVPPVQRVLAAGDKQDHPGYIPDHLPQFPDPHTYIRTDTRKQPVSEYQLIREKAASYKLIAVQPHPQPYLAALLPKDQDLDTLEASDIPTYTAPIPRGRADPDGTSVDPDSIDNPYLMPVKMPKYRKYKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1D4</accession>
    <name>A0ABY7E1D4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_009328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR02770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="67" mass="7994" checksum="ACB5C47260A6D94E" modified="2025-10-08" version="1">MDDSEERTPQLNQEEVTVQIEDCYRRCKKRTHEYVQRAENLEDAAANFERNPSRRESPCCKRCCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E202</accession>
    <name>A0ABY7E202_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">KI21A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_009007</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd01372">
        <property type="entry name" value="KISc_KIF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22248">
        <property type="entry name" value="Rcc_KIF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056533">
        <property type="entry name" value="KIF21A/B_hel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056532">
        <property type="entry name" value="KIF21A/B_hel_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF28">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23203">
        <property type="entry name" value="KIF21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23204">
        <property type="entry name" value="KIF21A_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25764">
        <property type="entry name" value="KIF21A_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="13"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="578"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="727"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="870"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1104"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="392"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="956"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="616"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="669"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1109"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="92"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR02449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1127" mass="126548" checksum="DCBE86F2236320ED" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2D6</accession>
    <name>A0ABY7E2D6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PA23-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_009536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12253">
        <property type="entry name" value="RH14732P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05826">
        <property type="entry name" value="Phospholip_A2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR02978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="349" mass="40102" checksum="0EBB05B1825B4F6F" modified="2025-10-08" version="1">MHVSRASINRMEDLYQILGCVSTASTSQLRKAYQDLALKHHPDKSPAGTSAEQFVKINRAWKILEDHDLRQKYDLKWQERCLAQTYPIQDTVDFDEFEEVVEEEEGEVAYKIKKVDVDRYDFDVTDGQYVWKASTSKSVDDMTSCFLYLHPSKAQQLVQDGEANRETVGQKKIKQMKKKCREYQTSARRATSADDHDTFNHDLAKTMPFKGDFETGAPSGAGSVHNQTDACCRTHDHCPFYIDRFETKYHYYNKYPWTVSHCDCDQHLFDCFKKVNNPTSNEVGKLFFGLLDVQCFTFQVGEYCSNESSVLSHLWCSKTKGMKAVMKQFPHKWADNGTDDSNSASDLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2K0</accession>
    <name>A0ABY7E2K0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="219" mass="24368" checksum="E628254AF6CFED7F" modified="2025-10-08" version="1" fragment="single">MQERSPSDDSQQGYQFPNAVLSNTDRQLNGQNDEQQERSPPSDDGQQGYQSPNAISSNTDTQLNSQNDEMQERSPSDDSQQGYQSPNAVTSNTDRQLNGQNDEQQERSPPSDDGQQGYQSPNAITSNTYTQLNSQNNELRERSPSDDSQQGYQSPNAVTSNTDRQLNGQNDEQQERSPPSDDGHQGYQSPNAVISNTDTQLNSQNDEMQERSPSDDSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2L1</accession>
    <name>A0ABY7E2L1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TF2H1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="1">
        <location>
            <begin position="68"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="BSD" evidence="1">
        <location>
            <begin position="147"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="491" mass="55341" checksum="66FCD837E4FC2970" modified="2025-10-08" version="1">MSRQSEEVLLIVNHVKNKKKISPDTKEKVQLQLVMHDGGANTFQLNNPKGRAAQVADRDSVKELLQQLLPKFRRKLSNELEEKNRLLQENPELFQLYKDLVVSQVITAEEFWATQAPKYSAKEKVEQNQTTGVSAAFLADIKPETDGCNGLKYNLTADIIESIFRTYPMVKKKHAEYVPHEMSESEFWTRFFQSHYFHRDRIAHTSKDLFSDCAKKDEDEIKMEVQKRNTDPLLDISSLKDGNIGDGYGGGIGEDRGGSASSANMTMIRRFNHHSTMVLKACEQAGSQATTASSQNGAARPANGSLAATQMNGETSHSHENTPKKARIREKLQFNDLEVTECRKTVNMRLSRMERYLHGPTPITSSRYTSSEDLISANNTVSAEIDSWNPNLTHVLLGSSAVTVLGELSPGGALMHGSTQQQLNQMVPDDVQQELKQSYSALCELLRHFWACFPASNKLLEEKLTAHMQDLLNAAYTKFETWQSRRMLRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2M7</accession>
    <name>A0ABY7E2M7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="116" mass="13109" checksum="506D1A7E92C98511" modified="2025-10-08" version="1">MCNNTSLLVENDLDLCKNNTNRRSMHLEAATSNVRRSAQAAVPVGSQGYRGLGISANAVRVHQDSFGEERRRRDTHTGSIFREQWCSNIDQVTCSDELRLVCGTNRKFYRNQGMTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E315</accession>
    <name>A0ABY7E315_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FA5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34231:SF6">
        <property type="entry name" value="AGAP006868-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34231">
        <property type="entry name" value="EXS-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="781" mass="86122" checksum="1172C4ED32F1ABF0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4X1</accession>
    <name>A0ABY7E4X1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MPPD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="392" mass="43523" checksum="00D944B0466EC895" modified="2025-10-08" version="1">MLPYFKEVLSSYTETLQLLWEVDEAGSNCTVVRADNCDFCMASSDPFFKINDFTVGNPSSKGISTKERQNRNLEETVLPSPNVIFAKPQIKFVCISDTHMRLYPKDVLNIPLGDVLLHAGDFSMKGNLPEIEYFNQLLGVEHPRDLLTNCIYLQEESLDRGQPLAEKWDKIPDNVDILMTHCPPYGYGETKKGGVHFINASMCTRGYRPINPAIVFELDNPLYQPDHSIVMTANNVGYSAVSVGFFKLSGSAAWVGFNMSGSVAWCCDESKSMKPTGDCVECCDESKSMKPTGDCVERCDESKSIKLTGDCVGPCDETVSLETSGDCVEWCDQCVSPETSGYCVERCEGELASDWKKSRYFVSPHGTGSQEEESKKEATLGRPRKRTRLGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E926</accession>
    <name>A0ABY7E926_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Angiotensin-converting enzyme</fullName>
            <ecNumber evidence="6">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_020691</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase M2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd06461">
        <property type="entry name" value="M2_ACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF27">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00791">
        <property type="entry name" value="PEPDIPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045661953" description="Angiotensin-converting enzyme" evidence="7">
        <location>
            <begin position="22"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR05322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="647" mass="74268" checksum="A0AA5E584091256E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9Y5</accession>
    <name>A0ABY7E9Y5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_021116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029131">
        <property type="entry name" value="HAUS5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28588">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28588:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14817">
        <property type="entry name" value="HAUS5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR05747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="502" mass="56371" checksum="01EFF316199EF0B4" modified="2025-10-08" version="1">MNRESELARQLQEWTTKEMHFNLQSSHSAALDPEKLKVKSKTSVPSYKVNYDVGGKQFEDSKQALLEQRAALTGEITTTLRDVGHFEHEVERITAEVAETERKYQQVKEAINNSRRKAALLTAFCVKSADNAAQYKEYVRCLQTRTATIKARAQKGLETEEYYSREAAGGDSDDEEETEEKTPALEIASAKHVRESCSEIGTFLQDTLNGAFTNDKALFSKQKEPLWQKVEQVCGTFSADQILTGLLTHTVDTTAALRSLTSKVDIRRDAQKLRPETGQDQKQGVIQVLVKQNMNAQSRLEEQLAEISDYIGRSFVSQPSHLTGLTGKLAGTVSQEVDGFANLVLPYLMFSQIDSALKTAVMDLSIHQTSPVHIRPALSTVLDCLNFKILDREASIASRRTEDDVVVNITELCDRARESDSQQLRQTLPRLQEKISRTNQALDNCTHSKQAADDWWVEPGQKKHFTTDSAGKQTQNFSITIFLWVETSFVKINFVTKLSVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EA17</accession>
    <name>A0ABY7EA17_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="91" mass="10217" checksum="93A006B74180FF08" modified="2025-10-08" version="1">MFPTVSVHSLPPAICQRSRNDFVYLPQGYMPRRRPRSASNADHPPLKSLIVQLIPATILVDADDLISSGDEGQGAQFDLENKRFIESHTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EB54</accession>
    <name>A0ABY7EB54_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Outer dynein arm-docking complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Tetratricopeptide repeat protein 25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_021013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040111">
        <property type="entry name" value="ODAD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23040:SF2">
        <property type="entry name" value="OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR05644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="627" mass="70782" checksum="1F6C355A9EC7567A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDZ5</accession>
    <name>A0ABY7EDZ5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="192" mass="22740" checksum="74538217F6D7C725" modified="2025-10-08" version="1">MRSLDKRFSLTEAEGRFQKACDQIVLLNHRLGEVQKRYKMAKRSNNKAFRYNLRLKLAVIEGVRNMYYDFAYSKADRVAELRRELFDESVEIRFSLTEAEGRFQKACDQIVLLNHRLGEVQKRYKMAKRSNNKAFRYNLRLKLAVIEGVRNMYYDFAYSKADRVAELRRELFDESVEIVSGSDSEYSSDDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFQ1</accession>
    <name>A0ABY7EFQ1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine 4-monooxygenase</fullName>
            <ecNumber evidence="3">1.14.16.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_017590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.1" evidence="3"/>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd03347">
        <property type="entry name" value="eu_PheOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018301">
        <property type="entry name" value="ArAA_hydroxylase_Fe/CU_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041912">
        <property type="entry name" value="Euk_PheOH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019773">
        <property type="entry name" value="Tyrosine_3-monooxygenase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF24">
        <property type="entry name" value="PHENYLALANINE-4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000336">
        <property type="entry name" value="TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00367">
        <property type="entry name" value="BH4_AAA_HYDROXYL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="9">
        <location>
            <begin position="114"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR07632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="423" mass="47786" checksum="6CAAAAD172EBB7F1" modified="2025-10-08" version="1">MDAGLSPAKRAKMTANGTNGTHDNGENQRVAGSYVQDFEDKDGSSSILFTVSENIGALASALKVFKSRPSRKSKDEYEFYADCDNQTGGLKDAIHDLKAKGCSITLLSRKHQRGSGRRSTSEASEVPWFPRHIRDLDRFANQILSYGSELDSDHPGFTDPVYRARRKEFADIAFNYKHGTPIPSVKYTPDEIKTWGTIFRELTKLYPTHACREFNHVFPLLQDNCGFREDNIPHLEDISNFLQDCTGFRLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHGSKPMYTPEPDVCHELLGHVPLFADQAFAQFSQEIGLASLGAPDEYIQKLATCYWFTVEFGLCRQEGQVKAYGAGLLSSFGELQYCLSDKPETRAFEPAKTAEQSYPITEFQPVYFIAESFDRNDTVGRFHLQVRWPLECIYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFY3</accession>
    <name>A0ABY7EFY3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_017654</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR07696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="186" mass="20685" checksum="0DEE776310C0D8F4" modified="2025-10-08" version="1">MSSLKQTPLTCSGHTRPVVFLNYSDITPFGYFLISASKDGKPMLRQGDTGDWIGTFEGHKGATFQHKHIVKCVDFSNDGNYLLTGSQEKILRIFDLEKPDEDPQAFSGHTAFIKNALFKKNGKQIISAADDKTRHSRVTSVLSTVYDSLPMARCMPVVARMEHYDSGRQQLAKLMASGNVSPQTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EG33</accession>
    <name>A0ABY7EG33_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SF3A3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_018941</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025086">
        <property type="entry name" value="SDE2/SF3A3_SAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13297">
        <property type="entry name" value="SDE2_2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="362"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="302"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR08983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="429" mass="50442" checksum="ABF3445DF0DB0834" modified="2025-10-08" version="1">METLLEQQRRYHEERERLMDSMTKEMLQPAKPGRDHINKDHRTRNLLRKEEVQALYGPNEFQEFYSRLKQLKDFHRKHPNEISVPMSMEFDEINKMRENADDNTNMVEFSDEEGYGKYLDLHECHTHFINLKGMEKIDYISYLSTFDHLFDVPKERKNAAYKEYLQYLLEYLEMYVQRIKPILDINKEMRTVLAEFEQQFSEGHFPGWPELASLGLDRLKSALMALGLKCGGTLEERAQRLFSTKGKRLEDLDPAMFAKSKPGRAGKARESEKQREIAGLEAQVYRFSELLSEQRAATRENVIRKQARTGEEREESDDEDTMADSDDDDDDVPYNPKNLPLGWDGKPIPYWLYKLHGLNISYQCEICCNVIYKGPKAFQRHFAEWRHAHGMRCLGIPNTAHFANEEFEDSIGNVVNKKTYEDMKRQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGB9</accession>
    <name>A0ABY7EGB9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_018098</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Protein-tyrosine phosphatase catalytic" evidence="6">
        <location>
            <begin position="115"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR08140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="239" mass="27146" checksum="6CE3BEF6ECD4A43B" modified="2025-10-08" version="1">MFKCGSSSVVAPQPVGMIVGIVVGGCWSEIDYKLCFAPTIDNVNQFWTMIFEEDVNTIVMFAESKAQKKELRYWPSDFNERTNYGHVDLEATYLNTHDAYTHMKMNICNSVTKRTINHFQCAQVSTFSPDGFVDFVKCVRSNVKNRRILLHSSEGLASTIPFVVMDTCMQQLSDGAIAEKVDVYKMLVNIVKTRKDLMPPQELFIFTHDCVQGLGSCDYESLQNTKQIESVYQTLQVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGN2</accession>
    <name>A0ABY7EGN2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CAF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_019111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="7">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR09153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="472" mass="53341" checksum="0AC058EADAB060FA" modified="2025-10-08" version="1">MTDKDGESFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDYSLHRLILGTHTVTLPSSETFGQAEQNHLLICNIKLPGPNSQTEESNYPENRGDEVLLKCRSEEQNHLLIASVQLPNDYTQFDASHYDGEKGEFGGFGSVSGKIEIEIKINHEGEVNRARFMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECQPELRLKGHQKEGYGLSWNPNMNGHLLSASDDHTICLWDINTTPKEHRVVDAFTIFMGHTSVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNNVNKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFTWNPNEPWVICSVSEDNIMQAENIYNDEEPDAPASELEQQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGZ0</accession>
    <name>A0ABY7EGZ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="76" mass="8488" checksum="7EEB9003AF0489C8" modified="2025-10-08" version="1">MEGKPVSNTDATRTLNAIYTFATIVPLYDKEQNKHDVGETKKVQMKTTYAERSDINGTSTTIVVLAQEDQVSDENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHC4</accession>
    <name>A0ABY7EHC4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031440">
        <property type="entry name" value="DUF4670"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21937">
        <property type="entry name" value="CCDC66 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21937:SF6">
        <property type="entry name" value="CCDC66 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="932"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1180"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1308"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1416"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1773"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="814"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="932"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1333"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1416"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1429"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1448"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1503"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1773"/>
            <end position="1782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1811" mass="201304" checksum="189F57FA8A9CF36E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EI28</accession>
    <name>A0ABY7EI28_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF3">
        <property type="entry name" value="PROTEIN GVQW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="153" mass="18624" checksum="3C9A939B0EC75A4A" modified="2025-10-08" version="1">MEDKNVRVRSSRTFIRKVRRDQSYLSQIITKDETFSHYFEPKSKQASMDKAPSNTARNQQLDIDVFEFQRAIHSPYSPDLVPLDFAYFPKLKTYLRETRFNDRTEIGHAVQTFKRTLDRDWFIDVYENWVRRHHKCTAHQDKYFEKEYYVTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIP7</accession>
    <name>A0ABY7EIP7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PIAP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_018972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR09014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="238" mass="26091" checksum="A2D7DF2AD413FFF1" modified="2025-10-08" version="1" fragment="single">MQHEWARFATFENYPSEHPCAISFSKNGFYYIGISTTVRCFACDFEINDLPDGSLIKDIHIHGSPQCPFATDESSQVLNVPIHSLGDRRPEPQTTANVPENSGGDRRQPSRENTGAKKTELGSNSAENSMEMDAVQTDGSGARGSAVSTSGQQNESSARELSSRTGFHAADRLETNINKVKKALQNENEDLRRQVSCKVCLDLDACVVFLPCGHMVTCEECAPAMRKCPICRSDIRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJ92</accession>
    <name>A0ABY7EJ92_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="14" mass="1555" checksum="7A59EDE023B65944" modified="2025-10-08" version="1">MVMSLQRIPGIPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKK8</accession>
    <name>A0ABY7EKK8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CARTF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029309">
        <property type="entry name" value="CaRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14694">
        <property type="entry name" value="CALCIUM-RESPONSIVE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14694:SF1">
        <property type="entry name" value="CALCIUM-RESPONSIVE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15299">
        <property type="entry name" value="ALS2CR8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="618" mass="67911" checksum="A71BC564DD7D9170" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENE4</accession>
    <name>A0ABY7ENE4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="120" mass="13252" checksum="BBC3AFA8B09C10B3" modified="2025-10-08" version="1">MESQAVGGSVVVTGVASVGFGSAVANTANASMYTEAAESCESRAESLRSQIEKQREKCRTEEREMNRLKSETDSLKKQVEDLVAVRDAAYAMIKAINKASNRLQEKWEEVNNLFDPHLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EP86</accession>
    <name>A0ABY7EP86_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_035953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR10877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="347" mass="39133" checksum="5017680B891D25CD" modified="2025-10-08" version="1">MPAVDCPIKGCDYQTPDLEPTIAAALITAHNATHISRNTAPMVEKADAVPDDYPMGSDPANHPSVSSYKKHLEHTATLPTDDDLFGDKPKAHVVHFETKPLQEPKISTVQNQDPVTAENLTQNEVDAYADDNSRCNKFSSCWKKFAFLFAIGGIVVPFAALGNGWRPLCKATREHIVKDHTREGMETAMQSHKRALCQGSYEGKDGDRYARPKESTLSRIIRGKGWRPLCEATREHIVKDHTREGMNTAMRGHKRAHCQESYEGRDGDRYARPQERTMSRIIRGKGWRPLCEATREHIVKDHTREGMKTAMQGHRRAHCQESKEGRDEDRYAKPQKSTLSRIIRGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPT6</accession>
    <name>A0ABY7EPT6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="87" mass="9679" checksum="98B464B063B8ACFF" modified="2025-10-08" version="1">MYIHEAFSDKQPVVFKAPPKISMPRIHRDLESDYDELPMGRCGSLSSVNSTTTTNTTDSSSSNKGNEETAFLSSLLNIFKMFTSNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQF0</accession>
    <name>A0ABY7EQF0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TRIO-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="78" mass="8798" checksum="55D01712F4F51619" modified="2025-10-08" version="1">MYVWSVSEEHFVRVPALFKLYMLVDSIVGIQAGSQEFLFEMSPSAVTPLSSLTVKVGESAVFTCRICGRPRPYRHMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERA6</accession>
    <name>A0ABY7ERA6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Apolipoprotein D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_025849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002969">
        <property type="entry name" value="ApolipopD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF34">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01219">
        <property type="entry name" value="APOLIPOPROTD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0873">Pyrrolidone carboxylic acid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="4">
        <location>
            <begin position="92"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR11669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="179" mass="20293" checksum="1CBB074F64F2738E" modified="2025-10-08" version="1" fragment="single">SPEANYWVVETDYDTYSLVYSCTDLEGFARAEIYWILARETSLPEATVNKLKQVLTAKELEYGKFTPNTHKDCPWKDGSKDVATGDAEAMDPNVPAKLSVTFNGSPRVPYWIVDTDYDTYSLVWSCTDIGGLLQADFAWILSRNNTLDNAIIEKLQNKLATFNINTKSFRQTDQSNCDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESH6</accession>
    <name>A0ABY7ESH6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ERG-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_026385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF304">
        <property type="entry name" value="DNA-BINDING PROTEIN D-ETS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="197"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR12205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="308" mass="35019" checksum="B8EA65021C9B0191" modified="2025-10-08" version="1">MSFQRNEWFVPNRNDVYLDSKTRIQYAHPAFVSQSVVSGNVQLQTSAPTIPSWQKASAKGQRYSANTDSFGRQLNEANDAPVKTFELHNGKEGFVPGVNTTVCRNGRVSNEQADCHEYIGREKLCACFGTPYSGLLNSYAKVSSERNYESLTSYCGPSPMGPQECYERDHYAPPYFPHLMPYRHGGDLVDIRRANPGRDGEFKLIDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMSKVHGKRYAYKFDFVGLAQAIQQNSESPHCSLGADMCVNSTGSQPQNHAAHNVDRDFSYQQTYSRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUC1</accession>
    <name>A0ABY7EUC1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="346" mass="39361" checksum="8F4CF6C5B6414F14" modified="2025-10-08" version="1">MQYDNLLSRSSILKSVSEVFVRSESAMVADLLAMFFMCAAHSCQLAEKEWAANSCSANKCQLTAEVIQHVRGTYNMIGELEKGKQDTDLQQRLAIKRQYELELKNDKLKKEIKRFRQTPACQRPTHPYSSHRMTPIRTQQSCRTSSCRTSSITNATATMPAIDDCYLCRKLWKVVGNHGKSKAHLKSCETSNNCVAIMQGEKKDIESILLSQLLSQTVVEALNELATDYNDRKAARYRQSVLNFRFIISLVGIEHMFSILVGLSKRLQPETIDLLAAVKETRVVVALLLFGRQQNRTNVPRDTPSQLWKTNVYLPFLEHLLADLDVRLLQVNSGYNAQYFIPTQVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUL0</accession>
    <name>A0ABY7EUL0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="118" mass="13819" checksum="BE46149A32C22F70" modified="2025-10-08" version="1">MAHETTYETTYETTYETTHVTTHETAHEATYETTYETTYETTHETTCETTYETTHETTYESTHETTHEATYETTYETTHKSSHETAHETTYETTYETTYETTHVTTHETTCETTCETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUR2</accession>
    <name>A0ABY7EUR2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">OXA1L-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_027157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR12977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="185" mass="20988" checksum="F1896D667840CFE4" modified="2025-10-08" version="1">MATSMRNVIFCHKSLPRSIQTEIPEGYIPDIPAPPKLELIDNLPDLTALGEPTLQSLGLASWYPPGRMQALLEFFHVSIDMPWYACITLTAVALRLILLPIYVRQRKFAINMGNHSQTVQRLQRQVEDAKTTGNAILEYQRKKREKEGMNRKYIEEAAFKKAGTGPVPKTYAYDPTKRRTGSSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVS9</accession>
    <name>A0ABY7EVS9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="396" mass="44982" checksum="CF7B52CB85B38C4A" modified="2025-10-08" version="1" fragment="single">AHIDPDRLKLALEPECASIWCETLGVAVKGTVAIAGSQYMVVDLGGGTADISIHERKPDGTLKEIHKASGGPWGGIFVDENYMKMLYRLYGEEALIELRKTDMDDYFDITREFEHKKRSFDTENTNHVVVRPSVLLRELADKHTKQSLEERIAALDIQDNFIKLMSKDKLKIDGTVIESLFEGPIDLLIEHIKSLLAEARMKCVRTIILVGGFGESPYVQERIKKEIAGVRLIVPPDAGLAVLKGAVRFGHNPAIVSSRKMKYTYGTDAFMDFDEKKHPDEKKVWINGEWLLNYCFDVYVRVNEEVRVDQMVTRKRIPTDTISLISVYRTTQENPEYITDPDCELLGTISIENSFDIPFQQQVIETTFMFGDTELLVKMMNVATGQIAYMILECFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWP9</accession>
    <name>A0ABY7EWP9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TIL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26803" checksum="720BAB3D04F50AE4" modified="2025-10-08" version="1">MTFIVKCSLLSVDMEDQETTGTTNDNTDVKYTQMERGSVQTTGSYFSMSSGSLPSHIRSVSPRQQMEFTLEKDVRKPQTCCNARTVYIALITIFVLTSSVAVAIAVYEIRVIQTSSRSQKLKNHVLPFQSVAEVGHSPPSSVAHMKAATLSPLPSITSGLHSEKPAEQGGRTPCNQICSTYRNDRFQATCQNGYCNCFGEDYQGDTCLPDVDGCKIQVSPSSKMISIWGSPADKFSSCGRQTIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWQ7</accession>
    <name>A0ABY7EWQ7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="161" mass="17978" checksum="C2EE658B49F1D1CA" modified="2025-10-08" version="1" fragment="single">MADDIDDLLDEVEHKFVKAKTKTEESNATKSAQSKTSQTRPKLSKCFPVFIGGAADPQGYGNTVNKRRKSGLCMSLLTVNQQIPQPALHRKVSLSAYFTGAYDLWVQLERDTYYCTGFMAVRTGANTVELIRAWRDKMVNLGNKKNDQAGFQSIVSNYSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1T9</accession>
    <name>A0ABY7F1T9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF6">
        <property type="entry name" value="PROTEIN CBG19234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="65749" checksum="A403BC7CA52005FF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4M6</accession>
    <name>A0ABY7F4M6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="142" mass="14845" checksum="AE4827787A5BDE6C" modified="2025-10-08" version="1">MLMMNHTDKDEPHPAAGGPPQRPRVPLEGKNAPRLVEITSNPGTPLKVTEIPDASSTALANIMRTPAGNSTSVVHAKPNSSSIATTQPNANSHSDIVKTTDVIVRDASSVKSSNSISTEQRSANQSPNSSPHASNNLVAVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F528</accession>
    <name>A0ABY7F528_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PGCA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883:SF12">
        <property type="entry name" value="SEA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883">
        <property type="entry name" value="YIPPEE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1207" mass="135500" checksum="A478CAB1F908605E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F551</accession>
    <name>A0ABY7F551_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_030427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="776"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR15833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="828" mass="92265" checksum="9EAFB95E775F99D3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F6B9</accession>
    <name>A0ABY7F6B9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTPRU-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_031166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="98"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR16572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="190" mass="21322" checksum="DFA2D54139A2CD42" modified="2025-10-08" version="1">MTPLEETVADFLCLTMQEKAACIVDMGKECSLYIPDLDTQAQFGLYTVDNLRQKSTIYSVNRVLRISYNGQGGPSEHTVSHYQVTAWQDNVNTPESATHFLQLVKEVETKAASGSVIMHCKTGGGRCGLYAAVWTLLEKTGIEHEVSVFNTIRQLRARRPNAVVTTEQYAYCHDCVCEYLQSFDIYSNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8E0</accession>
    <name>A0ABY7F8E0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="99" mass="10874" checksum="0B601E88D2C19300" modified="2025-10-08" version="1">MDFNLTAVYTDQQRGGPEGACTGSRTGSARATVTETRASETDGRRAFSTTDDATEGRCSGMKRNKHVISRDARKTYKSSDFDLGDQSVTTFKSDRIHIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBR3</accession>
    <name>A0ABY7FBR3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DZIP3-like HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_001383</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF300">
        <property type="entry name" value="PICKPOCKET PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR19545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="22122" checksum="C7C0EABC6C6AFBF8" modified="2025-10-08" version="1">MPNRKAKRYRAKSSPNIDNLPAPHGDCAMKELRQTTYYTTEECYLDCLTKYGQNTCGCRDTYWPYFNGIVFANATYVVADEFDRSIRERCKCPIPCHFFTFDPSSSYSSISNHLVAKLLTSKEVLGLEVKLLNAYGTSAKMDDEKSLQFESLVNEFQSKTNVIDDIIMKIYLNLEKQKNKTKEIFTSMEDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFP2</accession>
    <name>A0ABY7FFP2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="167" mass="19403" checksum="9591B564918D1B91" modified="2025-10-08" version="1">MDYLALLKQQAILAVLCAIQAYTLPYDRQYRDNYRTSPYKPSRFNYRPEFPPMPMVGPPFFYRPMPMFDPFNRTWPARPVRFRFMRRRKQYRGPGYTVTHAPTVVTRPKPKVTPKKISVVSGSLLNIVPHPKINATKARKKARLHAVAKAKSFPGILKNTALEVKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGC5</accession>
    <name>A0ABY7FGC5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="242" mass="28631" checksum="36464A0CCC335E22" modified="2025-10-08" version="1">MSTEVLADHMTITEMQATLEQAERKFRRACDQIVFLNERLSGCQFRYKKARNNNRKSFRYPLRMRLAVVEGIRDMYYDYATKKVEEIEHLRKVLATYVIDDIYMSDEEPAWNHTSNTILSPKTTTKLTITMSTEVLEDLMTIAELQATLEQAERKFRRACDQIVILNERLLSCQFRYKKARNNNRKSLRYPLRLRLAVVEGIRNMYYDYATQKVEEIGRLRNVLAEFVIDDIDMSDEEPADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGH0</accession>
    <name>A0ABY7FGH0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="493" mass="53194" checksum="F07D455B9224FB3F" modified="2025-10-08" version="1" fragment="single">MSESTPGSQKKGVAREADHSSQGNSQQMQFGILYPSTSLAGDRPSNKAPGTIEENKNIRTDSDGHKTMERSMLYETHTQSKFTNLSSYNDKSIQPKLKYTGKGPPKVLHGNNNQQSAASVRQSGRSKHAILQGDASSYGSAFDTSAGSDKLKSNGEYEISKQGRVWCIRDLKTNKLTTLKTIKADEVFFESKELVCVDGVFHQLIVHNGKKPKLEIAERSSSSSEDERKPNACDFSYGSDDYSESRTSPNSLPESEEPSSQGEETQSSDVNQSDERVSKQQNNTRSKYDDVSARPKRSLYEGNDRGQASPSYNPGSTGGSHDGSTEQPRKPRVTGTGQETEAEETQGSAVNRSNEKAGKQQNSSRSNPDDASARQKGSSDDGGQPSPRYNPGSTGDSHDRSTEKPGKPPVNGTGQEAEETQGSGVNQSDERASEKQNNSHSNPDYASKRKKQGPGDGGDGGQPSPRYYSWLTGGSHDGSTEHPGKPPITGTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHR1</accession>
    <name>A0ABY7FHR1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="18">CHP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MAR_002081</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">MELC-2E11</strain>
            <tissue evidence="18">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcineurin regulatory subunit family. CHP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051875">
        <property type="entry name" value="Calcineurin_B_homologous"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46002">
        <property type="entry name" value="EG:114D9.1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WAR20243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="61" mass="7136" checksum="CD021A5642F18E5C" modified="2025-10-08" version="1" fragment="single">MSVLARFRPTKSNESKNKLNTREEKLKFAFKMYDLDSDEKISRDELLAVLHMMVGDNISED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKE6</accession>
    <name>A0ABY7FKE6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PP4R4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_001529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039918">
        <property type="entry name" value="PPP4R4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21467">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 4 PPP4R4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21467:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="HEAT" evidence="1">
        <location>
            <begin position="226"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="1">
        <location>
            <begin position="265"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="639"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="689"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="711"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="760" mass="85225" checksum="5D6C242298C25E6B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKK2</accession>
    <name>A0ABY7FKK2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ACHAB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_016086</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046762096" evidence="6">
        <location>
            <begin position="21"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="7">
        <location>
            <begin position="67"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="8">
        <location>
            <begin position="275"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR22112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="371" mass="43031" checksum="39A757C9BE58C516" modified="2025-10-08" version="1">MKAVLVCISFICITNVFVHSKKNNKPQCNIQTKTVKNKLFPLVGKSREKRQTCKEYRVVHTNFRTYFKSLMANYSNYVPPYYPSKGWQRDENFVLDIRMQPEALVDLNDVDERMTTVLSFLVEWKESNLVWAGMNTFVYSVILDADMLWKPHIKVGNPHTSQRVKTDTNDKLTLEFKGEVTWSFVWTVDTRCKIDITYYPFDRQYCLIVLVLSSDLKDYLNFDHTVPHLALDNGNWKHMNTSIYNYTNYKTMKTHIVIEYTFDRKSVTPMLVFMAPVTILVSLSPLVFVLPNDGSERLGIAMTVLLAVSVYMTLVVDKLPDSSDPLPLITTVFFAWYVYNAFVTLLVLINGRISRISDKRSVPKCLQCLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLM9</accession>
    <name>A0ABY7FLM9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="161" mass="17964" checksum="CA565B343B6584E2" modified="2025-10-08" version="1">MANYGMNSLEYNSQETDRLQLSTNSRLNERYLIGNEPNESENGDGGNLISHSDTNNTPKETFSINSSSFPLRSANGSRNDPMFFHPNRLALGDVDSEDESVNEQNEDLQDSEHGTSPRDDPLYSQPIRTGLRDSDSEDEQNDVVQDSEHGKSHVSRMPNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FM68</accession>
    <name>A0ABY7FM68_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="342" mass="37037" checksum="CB7088D3B2188106" modified="2025-10-08" version="1">MATRKLPPPPSQPGGGRASLHGANPSLPTRKASAPPLSENGQGDSDQDEEFTEASSQELYNEIIRVVQAEEGQELYEVEPEPPGSGGAHRHPPPPEEQTYEETTTEDGLEMYVDVGEGEQIDQAGAEGEVLYEVLPEISGNNPVPQSGQKARKLDTDNESDNSRDIPPLLRRVSGGEKKPMFKMDQSALNSKLGKLRRVDSCEEPMPPNQVKDPTSPSFLKNVQLRPVQNKVVPPPPASSKPEVAKKPEVAKKPQRQMSASSSTSSIKETTNTPPPSPRSPTSPPPMPPSDASLTNGDDGEDIYDDATSLLDELHGEPMTSLPVNVFCLAFIVWAYDVKSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FN56</accession>
    <name>A0ABY7FN56_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SODC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_036423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="2">
        <location>
            <begin position="34"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR22754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="357" mass="36448" checksum="0BBD4BD8888C191B" modified="2025-10-08" version="1" fragment="single">MLGEKNFALYHEHKNICFVKHYSSHLFRFQLIGEGRQQVQVRVQLAGLPVSSLEAERGIHVHEFGDSGDRCSRVGPHFNPDQTPHGSQRNFAYLRHAGDLGNIRQSTDGLVSTQFVDQVISLDGANDIVGRAFVIKVERDDEGQGDTRDSRVNGNTRTPIACCVVGRTTAANWYNPLTANDIQNMAATGLMPENTVDPFAAGRQPGSNNQFQQGAGGRPQGPGQPGMPGQPGMGGPFGGSGQPGMSGPFGGGQFGGTGPVLPGGQFGPRPLGGTGTFGPGAGPFSGQTAGFGQPGSGGFRGFGSQGFPTGQQMPGFGGPGAAGGVTGFGQPGIGGQPAGGAGTPGFSGQGFGGQGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNW0</accession>
    <name>A0ABY7FNW0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RIR2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036455</name>
        <name evidence="3" type="ORF">MAR_036493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR22824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="370" mass="42703" checksum="8A07142B7F6BD22E" modified="2025-10-08" version="1">MLSTSRIQNENEIATSMNKLKVSQENKAPKQKVLGEITNLQKTVTPTAKSEIKSVKKVQEEPLLKDNPRRFVVLPIQYHDIWQMYKKAEASFWTAEEVDLSKDQAHWDALKDDERHFISHVLAFFAASDGIVNENLVERFSKEVQVTEARCFYGFQIAMENIHSEMEFLFNAIETMPCVKEKADWAMRWINDEESTYGERVVAFAAVEGIFFSGSFAAIFWLKKRGVMPGLTFSNELISRDEGLHCDFACLMFNHLVNKPSCERVQQIINEAVKIEQNFLTEALPCRLIGMNGDLMKQYIEFVADRLLVELKCEKLYNKENPFDFMELISLEGKTNFFEKRVGEYQKMGIMSGSKAESSGRHEFTLDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPB5</accession>
    <name>A0ABY7FPB5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34999">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34999:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR22857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1277" mass="144157" checksum="E91F71DF99F3E5F1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQW5</accession>
    <name>A0ABY7FQW5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_038274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="81" mass="8929" checksum="F3471FDEC5F76309" modified="2025-10-08" version="1">MGEDVGLTQRLVNGCWLKRSRQKLAEGGYKGGLLDGLVDVDEEANACERLRKGKQQKALGTHILQLLFIGLTGFSFRLPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRT1</accession>
    <name>A0ABY7FRT1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR23483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="225" mass="25947" checksum="B2A720FBAF733B69" modified="2025-10-08" version="1">MIVLQPARNNGGLAYNIKFDRTVLKYTKNSQVVTTIMFYLTDKTSNAVVDARSVSLPSITALMYWFVDANRVVHYGNGDRYQVYVFETSEDIHEATLYEYDINGYILTVDKDNLTRIIKDAWTTEDSSYKVTIYTTRIGYKENGDVVTSIKYLVEYNGVVRDARYYYGNVFRLALYINARLNTANGLSKDYTFMTGARLYFDEEVGFLFKTPTDILKYLTTQATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTS3</accession>
    <name>A0ABY7FTS3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045150837" evidence="2">
        <location>
            <begin position="19"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="172" mass="19533" checksum="C08C3C839F612CBE" modified="2025-10-08" version="1" fragment="single">MTDLLITLCFAMLTLVVGGGCEEWQFGHVLPCLKDVLYGINGTYNILAGTDTETVQTFCSYFKGITICTVNPVRDVCHEEAGAFVCVDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDADDDDDDDDDDDDDDDDDDDDDDERCQVLDKKRQFNATQHRTVKQKRRRIELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWU5</accession>
    <name>A0ABY7FWU5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CNGA3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_011821</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF13">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="178"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR26117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="236" mass="27835" checksum="5AF53D99780076F0" modified="2025-10-08" version="1">MDSFIPGKLHILLVRASRLLKYRTMVRFFDLTDSRTRNPNLVRTFKLSLNLWVVIHWIGCFYYLVSEFEGLGTNHWVYPNGTEYGVFSRKYIRVTYWSLMTLTTIGERPPPETDLIKSYMQHRNVDEKLQSRVKKWADYTWNRAQSIDEPSLLHMLPDRLRTEIAINVHLETLKKVKIFEECEEGLLRELVLKLRPQVYSPGDYICRTGEVGKEMFIVNHGKVETDGRCQGCRMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXB6</accession>
    <name>A0ABY7FXB6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046251039" evidence="1">
        <location>
            <begin position="17"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="107" mass="11489" checksum="D83719B234A9BD03" modified="2025-10-08" version="1">MAQLITWSCLLLVGSAAVHQSLSLSNVEFYEKLKPYLELDVAEEELETVANDGSDVILLPGGPDDELDIAFLLKELGFTPGNASESAVDPEIASLLDAFNQAPRKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXD1</accession>
    <name>A0ABY7FXD1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_011242</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasmic vesicle</location>
            <location evidence="11">COPI-coated vesicle membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the COPG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="13">
        <location>
            <begin position="209"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="14">
        <location>
            <begin position="583"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="15">
        <location>
            <begin position="730"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR25538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="844" mass="93734" checksum="744CAFECAE9A73F5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FY07</accession>
    <name>A0ABY7FY07_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR27067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="269" mass="30416" checksum="C2784F94085BB369" modified="2025-10-08" version="1">MSGKISIFVKLCLVVFVVSLFVGYTQWDPSIASGNRKTPIYKGTSKMIPMNTSSQPTVTSSLSSITQYDLRILLIVYNRAKSMLRLLNSINEAIFDGDNVKLEVWIDRSKLKLLKDLYSSTVIMSSEIAVILEDDLTVSPHFYKYLKLVHNKYDSIPEINGFALHGKSLKHGIGYSSQTLEGPEGCLLIATRQFSRTFPEMWLPSGLRFSRPRERQMGCGLTTNWMEAGLHFAKSANKPTNDLLMEWKSDYENLPDQPKHLDLKGVVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZB2</accession>
    <name>A0ABY7FZB2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZMY10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_011988</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052298">
        <property type="entry name" value="ZMYND10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13244">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13244:SF7">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="351"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR26284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="405" mass="46928" checksum="83B748EAB66D926E" modified="2025-10-08" version="1">MSAEGGGQVLLPVEAEAAVESLKQFPLKEIGGPKWSVQHEVLEKLNMQAILNASAQEDEFVKDYLITCDKLSLLIYDLLATEVWKEKVFSEILDTEDFDPKTTFPLYMVLYHEATVINLLETTMFYREVCEAAEDCVLDLVDYSVSLLRYIVDHLEGLPLSVMTRLLNTHDIPQLLVQLIGTPPWSHRKDGKQYKYIDGKWVQVDFADSLKLTKIEGQVWLSIFQLLMSTACQQKYELDTYRKNTILKLRSFLTEPMLDQIPMLGELQRYLEHLSMMDPPAPRREVILEQVPEVRDYILHSNEGKWKKIAKKQIKLFFDPSTSDLKMQAKRWADTYNFDVMEGLLSEPPKCAKCGEDASKRCSRCQNEWYCGRECQVTHWQKHKQACDLMFDSLKKLKEHEQAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZK3</accession>
    <name>A0ABY7FZK3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">OX1R-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_038173</name>
        <name evidence="13" type="ORF">MAR_038205</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="46"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR24504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR24536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="292" mass="33419" checksum="491C0486C8EF5E68" modified="2025-10-08" version="1" fragment="single">MQAKNEIVNITDEQLLKLVKAFIYPKVQHWIFLTLFLVVFVVGMTGNILVCYSVLCSRSLKTVTNIFLVNLAVADFLVILICLPATVVSDVIQSWFLGIIMCKLSVYLQRVSVFVSVLTLTSISVERYLAICHPLRHHGSYFKTKPIIAVIWIVSLATPSVDFYNMILVHDSEIPESLRPWLTVCGPRDETLEMEFNMVLVVVFFLIPLDLQYESAIEHLQVRRRTAKMLIVVVITFGLCYLPIYVLNIARYTNVLDGLRGNRVAVLCMYWTARFLCYFNSAINPVIYNFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZU7</accession>
    <name>A0ABY7FZU7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MEG11-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_013199</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="225"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="2">
        <location>
            <begin position="225"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR27495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="530" mass="62496" checksum="C8850899D00B69B0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZZ8</accession>
    <name>A0ABY7FZZ8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_012035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046289772" description="WSC domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR26331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="48691" checksum="EAB752A7699F9B06" modified="2025-10-08" version="1">MNLSGTAFMMIFVLCSEANELCTRNHTVKDQHTIIIDEACEWTVKASDKFAQLFFTATRLENDARLCDTDDSIQVKEDLTDNTVATLLNINCSTPYMVQLMFSSTAKVKVKASGADIILNMTFKEYRKQDFFISSKEEGYSQKNCHEFLDTKMQIGVRNLSVGEMLKPTEHEFLKFNHTFFESNNGTIVQGMQTCDKKCSTSDFFTFHDTVCYCLDGTLGIDTMAKYCSFPCQENLREMCGRPNYLTIYSSELCGQTFEENKGVYNFTAKPESVDVIASRSPIIIDTTQDQGQDERDRESDKEIALYIPVTVSVCVIVIVAIAIVIAICLRRKRGKKNAKVNVNEYNYSYTTTEAQTIHSFPAEQSHPECKPGEYTEVYTPQLPGNATNVSTTGHDANNQEDNTLYQQLQPTDPQESVYNDILPPSSEYGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G118</accession>
    <name>A0ABY7G118_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="199" mass="22603" checksum="578619108F1542DE" modified="2025-10-08" version="1">MAACDVFNTKIVQSKNQLMPTCSGKENLPPYDGVMYRTDFDTLPEIKFDGLFRFMVGKKKETASLTSFKALDRAVLHFHAGDVQDISRNIFIFHDDEYQMDYEFLYVRAKELASMKKIKYTVLAQSCSHIGGLLFAIKDYRQTASLHGDNLAYTSKLGARNVPRNITLDPKPISQLNLSKPRLPSHQPVTTRSCVEFDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G217</accession>
    <name>A0ABY7G217_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MIEN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="173" mass="19886" checksum="D38440BAC927CEC8" modified="2025-10-08" version="1">MGSEKRHFVSTTLADYATDKKGGAAYYEDGRNYDAMQTAKAIYYQNPQKYEAERKNFTYSQQSYGTSHRTTRNTYSGRVDVVVEHWTGCTNQGVADDIRMAVEDNFRDVKFTEFIGRIDSFEVFVNGKLLYSRVMQGGYPYEEEVLEAVWRAKHGKEIYQVDRFGGSSSCHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6L4</accession>
    <name>A0ABY7G6L4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="227" mass="24169" checksum="5C8A33C40BA573D4" modified="2025-10-08" version="1">MQSQLVALTMQVQLVACTMQVQLVSLIMQVQLVALTMQVQLVSLTMQMRLVALTMQVQLVALIMQVKLVALTMQSQLVVGHNAGAVGGVHNAGAVGGGHNTGADGGTHNAGAVGGVHNAGAVGGSHNAGAVGSNIDPHSAQLESETVKKISSMTIKMVILRIRINYEQTNGPMMLELTFAREDKYMLFSFKVTVFIHNKNNNNSSSSSNNNNNNNNKTKAPFKEDMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6R3</accession>
    <name>A0ABY7G6R3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">KEX2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_002612</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046015548" evidence="6">
        <location>
            <begin position="18"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="7">
        <location>
            <begin position="245"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR29044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="325" mass="35837" checksum="A6628F828F638463" modified="2025-10-08" version="1">MILTINLFCVLVPYVFAINESLRFSNTWLLQGPITEDEVKRVSFRLGFNFVKKLPTNHFVLTRGDVPHRSRRRYNYNNSLRKALNLTFIKQEEWINVSLRQIMDPKWPQMWYLNSRSGPSMGVEDTWKMNLTGKGVTLAIVDDGVDYNNPDLKDRILRGGKGVIYVFAGGNGGFDDNCNMDGYVNSIYTIGINGVARDLEPPGYAEPCSAVLASAYTGKGGTSDNLCTTDVNGGCINSFTGTSAAAPLAAGALALVLEAKGIKPKDTVRVVNSQIYTDGCNDTTYCVNRVEHVEAYIEFSYTTRGVIELSLESPSGTILLTIKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6S1</accession>
    <name>A0ABY7G6S1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="754" mass="84743" checksum="EA3DC360DCCA1C0B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G789</accession>
    <name>A0ABY7G789_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNJC3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_014610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR28906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="435" mass="48734" checksum="E02D0EBC141A2736" modified="2025-10-08" version="1">MECIRKITTETTYPIVSSDLAVAVWDRWKLDWVPEPVPSSVSSSSSSLGSIRDTPSPKFPITTRLTTLTMRAIYLKPSSSLEVVLSLVEVEKFSDELFSTGGDIFGCHGGSGDAAVHLDLGREMLSKGNLLEALSHFDIAVDKDPSNYLTYFRRATALTQRGSVYLKQGHLDKASRDFEEIVHYDPNNAEAVGYLHQIAPLGEEIQHAKILYNNHDFQGAIILLSKAIDLCPWDPELREIRAECYIAQGDLFKAVGDIRPTTKLRNDNTPAFFKLANLYYEMGDADESLSQIRECLKLDPDHKECFPFYKKVKKLAKQLKEAQDLSNAESWDDCVAKAKAIMKTEPKGFPFVQRAKSHICHCLAKAGHGSDAIKACNEVLEMEPENLHAMCDRAEAPQWHPDKFQEEDEKKHAEKVFMDIAAAKEVLSDPVCILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8N2</accession>
    <name>A0ABY7G8N2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome-recycling factor, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome-releasing factor, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_033312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="5">
        <location>
            <begin position="93"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR30770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="237" mass="26588" checksum="2D0401BF79FD43E4" modified="2025-10-08" version="1">MLHQRPIRQLLQLVQASRTNVKSSVVKQTLAACRENQTMCHRSLSHLAATTTSTHMHGNDQVCLQRSLPQLLYVPVRHKKGMDKQSRKGQKGVYGKLNIKTNDGTFPLNQIAAIVQKSPTLVVINMGKSAHYIANVMSTLTNSGMNLNPQQEGQATIYLAIPKVSTEHREKLSKSAKTIFNKTKDNLNGVYSKYLKNAGQRKQALPREVNQQMLMEKDDHVKNAEIMMKAKIDELMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8Y7</accession>
    <name>A0ABY7G8Y7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CADN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF53">
        <property type="entry name" value="HEMICENTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR30362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="156" mass="16917" checksum="2EA46DCEAAC8DD25" modified="2025-10-08" version="1" fragment="single">CPQIVFICLKSTAIGQIRVHGANVTSHADMEQGHVSGHVTIPRLCMAVIVVMICPDEWTSWSDWSSCSLTCGPGLKHRHRTCNYTIGTLLGGGCIGNDQERIECNLKSCDSYVLFYARGPTHEDIAYGETIVYGTVTIDKGGGYNSSNGVLLPRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBL4</accession>
    <name>A0ABY7GBL4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mab-21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF42">
        <property type="entry name" value="CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="318" mass="36920" checksum="8BCD9A7D9AF276EB" modified="2025-10-08" version="1">MVRHRRRDKYTNNDTIMNIHYIDITSHTTDSKGEGLVAPFESDTDRMYTYKYSMCSLTGDDSWKLPDTHIEFIMNGEQCHAGYFILGLKHKGSVVDKYITAALSADKNGRTYLSSPALTLFDEYGSTNAVVAFPCNSQEQLLLEWINRSRLHWPPPELIKEIKRLPAYLVPGSESKQEERRVCFTGEKKLIESFTESQYKLYIVLKFLNKHELKPICEELSRYIMINIVLWFFESNSEDSLVKGNMIIILISCLKNLKQAIKVNYLSYYLIPCRNLMTGRINPIQQAIAKLDELIHKGPRVILRCPKYWQPCRCLQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GCN6</accession>
    <name>A0ABY7GCN6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR28976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981:SF1">
        <property type="entry name" value="P2X PURINORECEPTOR 7 INTRACELLULAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981">
        <property type="entry name" value="ZGC:195170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="255" mass="30136" checksum="EE0D2CD0A8CF6522" modified="2025-10-08" version="1">MEKDIEDHKRENVKLLDRIRAKEEEIQKAREEEGNLKKRIEELEKECDDLNHLEEELKQQIKRHDKLEENVNKLEGDKKKLEENVLKLECQKKIIKENAIKLDGDKKKLAENAVKLDDDKKKLEENAKQLEADKMKCQCGECRSFQTVKILCCCRELPFLNEKREGVRCITLHPWFIANCLNKDVLYDGSKHLEFPFDEINMERASTLFCDWIQTDELSFKNGNVPACFFVAFMKTWLMHSRTANECTVMQMCLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GCX5</accession>
    <name>A0ABY7GCX5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TRIM9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_033951</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="217"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR31409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="785" mass="86537" checksum="C825A5476A116AC0" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D8E4</accession>
    <name>A0ABY7D8E4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SPP2B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_006423</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF103">
        <property type="entry name" value="INTRAMEMBRANE PROTEASE (IMPAS) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="10">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="525"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAQ93952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="574" mass="63630" checksum="DD5657BDFB2B2817" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDC3</accession>
    <name>A0ABY7DDC3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CRUM1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_007196</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043555">
        <property type="entry name" value="SRPX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46343">
        <property type="entry name" value="HYR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46343:SF2">
        <property type="entry name" value="SUSHI_VON WILLEBRAND FACTOR TYPE A_EGF_PENTRAXIN DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046919577" evidence="5">
        <location>
            <begin position="19"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="71"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="155"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="242"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="308"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="345"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ94725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="541" mass="60454" checksum="6E4C9EF40D609898" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DEG9</accession>
    <name>A0ABY7DEG9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S23A1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_007487</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11119">
        <property type="entry name" value="XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ95016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="584" mass="63209" checksum="5BF6BF3DFFE5428E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DF66</accession>
    <name>A0ABY7DF66_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GBP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_007461</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1000.10">
        <property type="entry name" value="Guanylate-binding protein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003191">
        <property type="entry name" value="Guanylate-bd/ATL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02841">
        <property type="entry name" value="GBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate-binding protein N-terminal" evidence="3">
        <location>
            <begin position="54"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate-binding protein/Atlastin C-terminal" evidence="4">
        <location>
            <begin position="178"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ94990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="522" mass="61120" checksum="0994A6A1DCF2987F" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFG2</accession>
    <name>A0ABY7DFG2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="229" mass="26120" checksum="C1E9262CC8D17AA2" modified="2025-10-08" version="1">MPPYIKRKSTNGLTVRKPKKSRTVADFLHSVLSSKWIRHRQHRNHARKSVPVLNPVKETMGTTCRRFILQKMGFDCTFEDRTLQRAYVGLVTLTIVQSLLFLVLTVSWRIHKEQPPLESSMYCVPCNDIKQTNPYNDTGHVIDALRQIYNESVCCGPIRRVMVLRIQNEMKKQYVENGQANPSLLVGKSFITDCEWQGMKTPTAKLVGVVDSVPSDIVQGNHNTVNKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGV7</accession>
    <name>A0ABY7DGV7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphatidylinositol-glycan biosynthesis class X protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_029619</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Stabilizing subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PIGX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAQ96929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="200" mass="22567" checksum="604786D7BAF1F79C" modified="2025-10-08" version="1" fragment="single">MIVSYPRCHGLVSQRGHFPMDPANGPRHWNLNITDSSPYNNPFASPVKPHLLVPLMAHLVVPVPLHAPRPADWTEKELLTSVDMPRELLPDYFDGGDIDCHMLFREVIPSGAYVDPFQLQEQRHFGGPDVKVVDPVDVEKPEVQSFEIVALVYANLTSDGYRGETVRQESLGCSSSDIILCDWSMIQLHQNNSFTYPFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DH75</accession>
    <name>A0ABY7DH75_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_029016</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="115"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ96326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="384" mass="44045" checksum="BD8DCE5F89C8547E" modified="2025-10-08" version="1">MAFGGSSVYKGSDLIHDYSCSKCAENDFNTEAQHFCPECEHYLCDKCVSKHGEYFKKHVVYGRGDIQKWAGFSMDRCDQHGNKLEVYCNDHQELHCSSISHLPELAKGFLKTAEFKQLSAAMDEMRFRLNDLKNAKMKDQASIKDSYKTILTEIKALRKELNQILDKLEQKTVEQLDYMMKDLEKSLKDDIETCTRMNDLLKTMMEKFSQITGKNKETNCYVGHMKCQTKLIESQNLVQAIQGKPEEALHFKSDSSIIPFLRNLHMFGAAERVVAIAKRLDCNYVFKSQGSKKYSVRIKKDKNTCKIIGICELPSGDLVIADCDNKRVKLLDRKYNVNTHFDLPDYPVHLCNTTGSEVALVTNTTHEIYILISHKLYTVLILDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJQ8</accession>
    <name>A0ABY7DJQ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TOR1B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family. Torsin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF2">
        <property type="entry name" value="LD13476P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="TORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06309">
        <property type="entry name" value="Torsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="287" mass="32875" checksum="FDF30554794A99CC" modified="2025-10-08" version="1">MQGLSYAMNQKLYRQHLVIGPTVKHLRGHVETPPKKALVFSFHGLPGTGKNFVSSMIAEHMYAKECQYVHYFSATKDFIHEGKLEEYQYIIKQRIVAAVQACPQSLFIFDEMDKMPSGIMDVVKPYLEFNQPVDGTDYRHSVFLFLSFDRLPGIYSNMGEYNIIMVAFFEIPDALKNSDLVRSSLISAYIPFLPLERRHMEKCIIDGLFAKGYYQYGIQIDHDLVKQIFYFPKDTQLFSTTGCKRVATVKHLRGHVETHPKRPLVLSFHGLSGTGKNFVSSLIANDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJU1</accession>
    <name>A0ABY7DJU1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_029048</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF6">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ96358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="575" mass="65992" checksum="EF2F8BE847FE129B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJY2</accession>
    <name>A0ABY7DJY2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="478" mass="53641" checksum="873A26CA45593EC9" modified="2025-10-08" version="1">MAAIKQLDLKTQLFSSSSGKFHNRGSGKLFRSTYHSNLYSKDSEHDLSANSSNRSHDDSSTNGLDLIVHPDFTDNEGISTSTPRSVPNYCRRTQSAKARTRLKPQISGRREKCRPASAGNIRQGGRAAVCSDKPVAVIDLVDKVIPELSDIDRERLLALPDPKDFNNLHELPPMHFSRPSSAKYDMVYADNDDQSLSKRKKKVRKQENDLKPSIYGLQRNRHFYGSAPDLTSTDSNLEQFPYKCSDECVDKTDNGPTQSDKRTTPATLDPLLPWLQHNIPDGALGVDPSQCLVFLTPVDWEALPEVPDELGAEEDLPYVRDITSPKPWNKQPVEEWVCQHGQTPVPPGEGNVIYRHTVNMPRMRTADVVRKEITELENLMKGVGRQESECGMVQYQSEIAAFKQALQDTLELVPERLKNPPEPVDTFGMKKIFTDHDSAIQGIEARVNECRAELADLELEAGISTARRHFTRPRSAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKS6</accession>
    <name>A0ABY7DKS6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_029980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="24"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="167"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ97290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="554" mass="61770" checksum="B152BDB83B211BDE" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMY7</accession>
    <name>A0ABY7DMY7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051941">
        <property type="entry name" value="BG_Antigen-Binding_Lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713:SF6">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713">
        <property type="entry name" value="FTP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ98709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="225" mass="25045" checksum="B54ED7C805902A66" modified="2025-10-08" version="1" fragment="single">MDSVLFSFIIMSVLRDSTETATEFDVIAMLKDTDQLPLVTGSNHWSDWKPDKIIDGIYGGGKATACTCCAALKTPAWANLDLTSPFLISRFEVFGRTDDEKVGEQFHNITVSTGRTDLEVLYAGFGAIISGNARQSETYMQCTADKALDGKRIFSETTSSCTCSVTKNSNKNAFWEIDLSTQHLIEHIVVTGRRDDNTLNFAVIDSICFPTTTEMTCFRINRERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMZ9</accession>
    <name>A0ABY7DMZ9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_023445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045779693" evidence="2">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ99072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="71" mass="8319" checksum="F32A78E9B85D4E27" modified="2025-10-08" version="1">MSCLSWCCLWLCFCLHNMLGLLCKQGHDLLFLNSCLLITMSCLWWVLFMIVFLFSYFAVLVVLPFNYGLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPA4</accession>
    <name>A0ABY7DPA4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PALD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_029520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14566">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01301">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ96830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="981" mass="110887" checksum="EBE704685C829503" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPK8</accession>
    <name>A0ABY7DPK8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045622705" evidence="1">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="167" mass="19050" checksum="13D94C0904EF8EBE" modified="2025-10-08" version="1">MLLLVNLLVASQAFITSSNDEYQVWLTTGDGSKKLRREAPWLRTPNGHGYSVWVDRTKRRQSMGCFGASLTNAAAYVIYHSPNRHLIMRDLLGNSLDDLGVTFLRLVMGASDFQGVNPYTNDDLTNNHNTDYDLNHFKDRAFVIPKRQTISIPISVFSLRRRRRPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSE5</accession>
    <name>A0ABY7DSE5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_023887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ99514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="150" mass="17500" checksum="2387EAC930967351" modified="2025-10-08" version="1">MGNVINKLCCCGGDFRDKLLNLCGYNRKNKDSFNESETSSLIDDDDQHSKDKESMYGTTPPMLPSPSPSPIKKRHSKFEQTIRSWIPGQRNEYNKPTIQSLKYDKERLETEVKKLQNRIEEEQVERQTLFSEKEGLIHELEELRTRLCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSR2</accession>
    <name>A0ABY7DSR2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="78" mass="8941" checksum="7207F34514464B70" modified="2025-10-08" version="1" fragment="single">VEKKRKLLVKIGKSRYLGILSCIGLDGYLRERCQDDKSLVFLNDDDDDDDNYDDDDDDDNDCGKRDKDDSDDSDSDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSZ3</accession>
    <name>A0ABY7DSZ3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_024168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="298"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ99795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="57824" checksum="C5C2CE0F14248DDD" modified="2025-10-08" version="1">MKMPKFGGNSDVHYDSLQYDNEPVDNNSPDSDSAELVSSSYSFNSRCYCGEAQGHEWAHTSQWMPPLSLTSEPDAEVPLESDIDLYDSQTGTQSIYSSPVHQEASTNGLHSDIPYSVPPKKHPNNQVLKIKRDKCRSYKSFQFCGGRCIEAVRLEEENAQLRGKVKELLQEIEKLKGDSIERSPSPVFKREKEMTSNSQLLEKKKNLSEKEVVAWLKSIDNTLRSEEAHENSYRTIITKCENAYKSLKRSESKSEAKIELEELLEKEISFPTPIGVNRACKPKTTIECQGSCSYVNASYDLAEEVNTLINENNDLKKELYTLQKKQNLKIKYICITATFKKQKNTELKRVRLRLARNETKFDKLNREIVKEKKLIVIGGKYSCELRTCIYSLLGLNIAASNVSSVRNTVLNLVGKKVEKLPSRTTILDMNIERLVLSQKQLNETLPNKDNMTLYTDETTKFGTKYSGKYSMTLMKGHLKQTRQAAQRVLANITSTISDRASTEKRFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DT38</accession>
    <name>A0ABY7DT38_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="361" mass="41722" checksum="75F4948794A991C4" modified="2025-10-08" version="1">MGCVEDNTANVTLPDDISISIVIFNRHAKFDKPSYNWENTELHSFKSERGLIKIGCMQAQLDQKDYEIHALKENLKKIAQDKRQAEMEKQDALTSYEIGRGYLSKAQGQNPSIADLNDPFRPTKLAEMFSELYENEWTALYTVMENYTVKDKHMIDFLSMNHLHFAKRNLIPTGRWYLNENLPNSQALKKALKYGRKTMVARLFTEIEKKFNTYLCGFFKNASFRPVLTSGKMKEYVSSCVKLSLLMNASDLPVIVDCPGWVPCTPDYHLKQDEHSGVFRQVTVNAEGDESKTKSTLDLKERRHFNKELFKVYTVRGKYAEYVYLHKNGPVLAKGIAQGAKDKMVSDDDHLWEWWKTTDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DU49</accession>
    <name>A0ABY7DU49_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FKBP8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_024575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF1">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="108"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR00203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="368" mass="40613" checksum="E06525D9A4733A72" modified="2025-10-08" version="1">MDTTEPLKHEDTQDKMDPAVGASGDDGDSLGTAAPDSPMGKQAPGDGPSSEASEGTQDPEDEYTDILGNKTLLKKVLTAGTGPRPNMQERVKIILLQEMPELGTTLPEQTLEFVLGQGDVAQALDLAVALMNIGEKAQVISGYQYMYGEVGMPPDVPAKTNFKLTVTLLEKKKERGNYYFRRKEFERSINSYSFALKVLEPENLRKEGADNLQKALEFRAIVQCNNSAAFFKLEAYEPARKAAEESIKLLASHTKAYIRLGQAQEKLGNADKAIVAYKKALEQDATNKWLHSELSRLTKVNHNKKKDQREMYSKMFWGSNPPDMSNSGKAKPSKAEPVNWLKLGGLGFIGFILTGLASFGIQRYLNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DV02</accession>
    <name>A0ABY7DV02_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="137" mass="14627" checksum="A9E8ED08B0714A3F" modified="2025-10-08" version="1" fragment="single">NHNRLQDKPLEAVKSRRRQQISPITRMGQSSSSRYREEEQANGRGSRNRNKNMKRAKQAAKKLKKADIDGVDGEATVEAPPEGGLSGWAVCGGSAVITSATAVVRTTVHVSVDSINTAFNVTKAGNKTTGNVTTPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVS9</accession>
    <name>A0ABY7DVS9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510:SF3">
        <property type="entry name" value="ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="76155" checksum="470D53A02E77E82E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXC7</accession>
    <name>A0ABY7DXC7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CLC4G-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_007856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051379">
        <property type="entry name" value="C-type_Lectin_Receptor_IMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46746:SF9">
        <property type="entry name" value="CD209 ANTIGEN-LIKE PROTEIN C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46746">
        <property type="entry name" value="KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047391093" evidence="3">
        <location>
            <begin position="19"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR01298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="145" mass="16495" checksum="F45EA74E58879D7E" modified="2025-10-08" version="1">MKFVMILAFSFILKVALGNTVLQSSCQLDLETTVSKSLELLKNALGRGECSPTCPNGWLSYESSCFLFGNAPSTFADAETFCEDRDSHLVYIKDNSENTFLKDTAREMKLPEYPKNREQHNILQWNIAILTYNAAIVYRIDIFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXD2</accession>
    <name>A0ABY7DXD2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_008965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045740389" evidence="2">
        <location>
            <begin position="18"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR02407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="242" mass="26573" checksum="40CD8D4E017D2678" modified="2025-10-08" version="1" fragment="single">VIITSLAVVFICQCANSWTIPSTTTEVPPTDGVTMPTIRFDATSTITDDLTSYKSHTSDVSDSTTKSTQTSTDFTTSLPLTSELVTDVAVDRTVLRTIVENLVILKIKVDKDMDSLVANSGISQYNLYTDEVKSQRPRLPDNIADMAKQCQYMAVLGAIEETYSQFLPWAQQVKGAVFNALRQTIYTIHTSVHAKEHTSSTPSPTSSTDSDDIYEILKTLAALSYQNNDATNAVFDLYRCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZ21</accession>
    <name>A0ABY7DZ21_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MTNB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_008732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="56"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR02174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="102" mass="11749" checksum="AF45D4E7B8C59DF2" modified="2025-10-08" version="1">MDVNLRDKICITPSGVQKERIHPEDLFVQTIDGIDLDGPPTAKNLKKSQCIFVFMHERDLKKRMAIAMEDYPESCAILARRHGVYVWGPTWEKAKTITEYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZL4</accession>
    <name>A0ABY7DZL4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027814">
        <property type="entry name" value="DUF4562"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34833">
        <property type="entry name" value="GENE, 17359-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34833:SF1">
        <property type="entry name" value="GENE, 17359-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15123">
        <property type="entry name" value="DUF4562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="167" mass="18063" checksum="D0F39FB3C4DC83B9" modified="2025-10-08" version="1">MFFIHAVDMFNYTANIKSNFGKKLMYKQTTLTVTMLTPPPSSGSVQARDGPASFDGEHDDAHDGADGKKHTTSNGTARATPVTPAHKSWTAFQGPVLYTGPSGLRDQRVRTGHEFLVTGENEASSEITSQMGYLNRAAQGQAFPKAKNGQVGEIGWLYDTLKVVKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZW3</accession>
    <name>A0ABY7DZW3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KHK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd01939">
        <property type="entry name" value="Ketohexokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034093">
        <property type="entry name" value="KHK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="318" mass="34864" checksum="0CF10F9E7B89D945" modified="2025-10-08" version="1">MEQHTSRRVLCVGLCCADIINVCDHYPKEDTDQRSADYYWQRGGNASNSSSALALLGANVEFLGTLVRGREFLTDDFAAYGIHADQCPVSEESPDVKGAVAVIVINRQNGSRTIMAAINHVPELKMEHFQNIQLHNYKWIHFEGRQNIDEIEKMIQRVQEYNTSCNTDQRISTSLEFEKPRLPGLGRLLDQVDYVFVSKDLAVSRGYQNKEEAARGFMHSCRPGGTVICAWGDDGAAAKTGSDDVITSLVYSPKTVVDTLAAGDTFNGATIFALSSGLDVGGAIRFGCMVAGTKCGMVGNKGIKGLQNQLDSFRTHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E191</accession>
    <name>A0ABY7E191_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IMA1A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_010328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16356:SF1">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16356">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 6 TMCO6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR03770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="267" mass="28960" checksum="EFB8BA7EC1CCF996" modified="2025-10-08" version="1" fragment="single">VENSLQSVVGLLTGNDADLQLEAAWCLTNISAGTSEHALAVAKMAAPYLITYLGSSNNALQDQCAWALGNIAGDSAECRNLLHAQGIVAPIVNLLKSPVPAVVQSAAFAISNIARESPAVTRYPGYSPSVHEPGQREQGHSNRDRLDPYLPFYNSYPIVTPLLRCLGNVCSGPDEYTEQALENPRLLHTLGVYLDSTVKYVVKETLWVLSNIALYVLNNLACHGEEACSCLLRHKVLQGFTPTLKTHDADVLNLALGFIEMMLRMCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1T8</accession>
    <name>A0ABY7E1T8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DZIP3-like HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041249">
        <property type="entry name" value="HEPN_DZIP3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18738">
        <property type="entry name" value="HEPN_DZIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DZIP3-like HEPN" evidence="1">
        <location>
            <begin position="44"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="162" mass="18652" checksum="96C2F3F6C5D59337" modified="2025-10-08" version="1" fragment="single">MSGAGTPGSVDGTQNEQYYLRLHLLLMKAGDVLRTMFDSIITPANLLLELRNHKRVIDKLKKDGILSNDQYILLNPNPASKRFDVSLLIVLLRNICNLQPNNPFWKEKDNNKITDTMPPVIANIVRIRNLRNKMQHKHVAYLDQKEFEDNWRLLGHVSVIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6H3</accession>
    <name>A0ABY7E6H3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="30011" checksum="3A92D472D60AFCA1" modified="2025-10-08" version="1">MAEELQQMMMQALNENSNCLMKHAQHIESNNRNLVQCAQVFEGNPKAFENWIKDVDKHAFLNNSSDKRKQLLSYQLSTGVLLDYIKRYLDSDEGETTWANLKDNLASRFSPIVDKPKAFEMPVSMRQKRDEDIQFYAERLLTLNKMISKKPTIESQLLSVFLSGIWDRDIRAQVERNNPRAFDDAYAIALREQTIMYKCAARKLQPDRLERVDRPSFARDQVPMEIDHARRNYNGRRDVNRHRPNNRYDDRRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6J2</accession>
    <name>A0ABY7E6J2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_019924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR04555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="190" mass="21527" checksum="21BECFA367B87AE9" modified="2025-10-08" version="1">MELMSWNDPLCDTISDKKVCHAFTRLRRVRSFESGSQLEKFHCCSADTYADFLVTVQWERPPVDGANTTHVIPVTCCKLPGKWPDYGEPSDMNCTLTPTSENSYIDHPCWKELNWYLWYYGLLMAGCCVGSLALEGVGIAVAVWASMDLRSRQLKIMIEKRGFVDPNVPDPNARDDDEFGDDSYVNQGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6Z4</accession>
    <name>A0ABY7E6Z4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MDGA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_021127</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="193"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="402"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR05758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="496" mass="53917" checksum="49E2DC372803EF6E" modified="2025-10-08" version="1">MTAIAGALVLTSDKQYAQLQGDITVTCNTSENVSSVEFKRDNNYVGRCNAFICESTDTNKSIVIQNNISSGNNLFALTIKNFKVNDTGYYTCVNSNKTEQVSGKEVTYAVDITLVTLTPKANPISVIENTPQLFQCLTSICRPKANVTWYLGSEQLTSATVSSPSQDVTASTLNYTSQRKHQNMNIYCQGNGPSQIVCKLGGSTMSSGVSVKEGWEFGLDCSSDGNPSPSFSWTHPGDGSSNPLFIRSINRTHAGRFTIIARSNLIPSEQQTVNLTKDIYVKVEVQCTLGILFVLDPPDPPSCRVGSSAISSNIVSAIRGNTISINCSCDSNPPSRNSWSVPGVSTPTSGQSFDLVVQKATTITLTMENSMQFTNGKNEQGRHESPIEVKVLYFDKLRTAVPPVVKPLKNVTVLEKSQVSVACEVTAGVPNKTIFRWENISDMTSVATEQTLRIVNISRAQGGYYRCNASNFMEPTGYDSTVGSCNNTVYIDMRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E707</accession>
    <name>A0ABY7E707_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PSG5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_021194</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052598">
        <property type="entry name" value="IgSF_CEA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337:SF20">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="63"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR05825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="157" mass="16717" checksum="E2BC1A134E273681" modified="2025-10-08" version="1">MCQADCNGCSFSWSRGQTTIVNTDVLNLMSLLVNEAGQYTCTASRTGATTKEKTLSIKVIHGPSSGSLNPADTHYTVEIGETLATVTCSASCWPCSYMWTGPGDFSSSGQTISLQGATKAWDGRYTCTATNDRTSTVSSTYFDVNVTDQIALLSTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E959</accession>
    <name>A0ABY7E959_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vesicular, overexpressed in cancer, prosurvival protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_020861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR05492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19060" checksum="ED4EA65CCE7C8D21" modified="2025-10-08" version="1">MTSCDYRSTFYITETLTCEFGCCEHGCCSDEQMKEQLKNNLSKGEIAACVLAPFTFVVVLYFVVFLCRRWNMNRQAAILRNLIEASNRRPHLDLNVTGVNIQPSAPASPPPLYTQEPEVPSPPPAYTQVAMDNQYTQSEPTLDTNGPHNFRGARFADPNRYRRLSEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EB53</accession>
    <name>A0ABY7EB53_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="148" mass="16694" checksum="96E0F81F9616AA05" modified="2025-10-08" version="1">MGGETTVKKEAEVGKEGKVTQTQNRVQQEHDLQKEVEELKGAVGGISANIKNMHETLAKVAAEQIAANSYVPKYQRHWTDSSPDQADVVEQEGIADRHQHDNQPVDPPLQEVPIDEPEEPQELRRSTRRTRPPDWYRNGFAYLQSGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDI8</accession>
    <name>A0ABY7EDI8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="72" mass="8145" checksum="546541032BF9D23B" modified="2025-10-08" version="1">MAVDVYRTFSNSSQISATRRSRRAMLLYSMYGWMLPAVLLVLALVFEYGLSSKKISNWKPSYGTKGLFIGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDK0</accession>
    <name>A0ABY7EDK0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="97" mass="11133" checksum="0AFB9862F3274E7F" modified="2025-10-08" version="1">MYTNSLHKVNTFKEKWDGRPVFKEASVRKWEGRLGFEDASVRERDVRAVFEEASVRKVDGTAMFEDASVREWDGRPVFKGASRSIDTVASFILNAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEQ7</accession>
    <name>A0ABY7EEQ7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_018468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046054823" description="EF-hand domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR08510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="205" mass="21933" checksum="854BE18982CC1231" modified="2025-10-08" version="1">MLFKYTLVLVVCVVLLDPSDAWGRKIKKGLKKAGKSIKKVVKKHGCKALFSFACPAGVAAAGAAVAVGSGGTGAAGAAAGVVAGQAACSVGGKKTCKRSVDMNVNIVPFSDNIRDYDVNGDKLVDYEEFVFSIMTTINLAKPMELRKPFTFADVNGDGTLDTQEFNAAPFLFAREYGYSLRVSSNKGSLLVVLFEWLLQDDTWLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEY5</accession>
    <name>A0ABY7EEY5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SRCRL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_017602</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="94"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR07644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="341" mass="38579" checksum="D55C287AF4524E94" modified="2025-10-08" version="1">MYFSADRCSFEAGTCEWRNVQERDHFDWGVGDCRHFIDTNTDENKTGTNNCAFIESFGPNSTRNRAMLRRPLSKTPVVISFQAFTNTDAVIQNIQLVDGPTPMSGRVEVLINSRWGTVCVDRADIFFAAVVCRMLGFLTNNAQVLSLQWYQRGVGTQPIWLDRVTCNGSERRLEECRRSRYDFHDCKHSEDVGVACYNKTVITAKTTTTASLQENEPGSHTNNYILIIVCSSIAAGMFSIGLCCCGYCWHRYQIFSKDAIRQQISQTQYEVETNANTTITVNTLQSDGTHPKPDDPPPPYSEICFLPSNDGYTMQAHYHLLSEPPSYDYVMASPRDYNVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EI35</accession>
    <name>A0ABY7EI35_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="108" mass="12521" checksum="EF80D999608AD89D" modified="2025-10-08" version="1">MNNTIILKQTNWLDWKSYLQLDFLPVRGIQKYHSFRFCKADSSAVYVKRKSGEPEARVQLMKRAAVLPQGMPNTVTAAGLTAERRRYLRMHVRQYVRPACSDSTCPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIV7</accession>
    <name>A0ABY7EIV7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="87" mass="9317" checksum="6A6403A7898FE2A7" modified="2025-10-08" version="1" fragment="single">MAYGRTGSVRECPTAASPTPTPPGSRAFPEFSISLMSQWLYSRTAGLVRKCPTAASPTPTPPGSRAYQEFSISLMSQWLYGRTAGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENR1</accession>
    <name>A0ABY7ENR1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase</fullName>
            <ecNumber evidence="9">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_035743</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="9"/>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR10667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="310" mass="35498" checksum="CD471248B3579C1E" modified="2025-10-08" version="1">MAKLRRSAKRLPQSTRVLLHSKGRHLHPPREHKTVKAAAFQAQEKELVFDIDMTDYDDVRSCCSGADICDRCWPLMQIAVKIIDRALRDDFGFEHLLWVYSGRRGVHCWVCDETARKLSQTGRTAIAEYLSVVKGGENQTKKVGLEENPHPSIKCSVDIVRERFKDYAVKLQDFMGDEDQYMKSDAKRSPNLEDEVMLQYCYPRLDVNVSKGVNHLLKSPFCIHPKTGRVCVPIDPENIDSFDPFAVPTISTIVEELNKAGTVGDDEKKVRDYNMTSLKPCIHVFNRFLSGLEKSWQGKMIEQSDIKMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQ48</accession>
    <name>A0ABY7EQ48_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRI33-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_026258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR12078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="219" mass="24801" checksum="5E8B15127131E3A3" modified="2025-10-08" version="1" fragment="single">MASKHTKSSKDSMSMASDLIHDFVCSPCHEDKLNTEAKYFCGDCSKYFCDKCLTLHSKLFKQHVVLGRKDVDKWVGQGDALISCDFHPGKVIELLCEDHAEMCCHLCVSLNHRMCRTISLISDLAKDVYKMADFKQLPSKVAKITTSLNQVREVRKKNQGSLKTSGKSMLTKIKDLRKSLNQLLDELEKRTVKQMDSVLADLDVTLQKDIDSCTLIHDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQZ1</accession>
    <name>A0ABY7EQZ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TBX20-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_025544</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd20193">
        <property type="entry name" value="T-box_TBX20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF190">
        <property type="entry name" value="T-BOX TRANSCRIPTION FACTOR TBX20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="8">
        <location>
            <begin position="102"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR11364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="437" mass="48945" checksum="70E251C584FE3F26" modified="2025-10-08" version="1">MIRDEVERISSPTTIKMSSRASAFSIAAIIGEQPLRRASDNVSPSVSDSDSESIRDSDLSREECASPGDTSAFSPVPSSRGSPAPAPATCTSEELVGCTCKLETRELWEKFNELGTEMIITKTGRRMFPTVRVSFSGLEPTARYSVLMDIVPVDKKRYRYAYHRSSWLVAGKADPPPPCRLYMHPDGTFNGDQLMKQTVSFEKLKLTNNTQDKNGQIVLNSMHKYQSRIHLVKVDDVMKTPPTSLLDLDHKTFLFPETTFIGVTAYQNQLITKLKIDSNPFAKGFRDSTRLSEFESSMEGMMQTTCFPRTPLRSYGDPEMIDPLRISPQERHKAMAESMSVSWRQMPTASSIQGFQAAIPSSLHTSLPLTSSDPAMFSSLYNSMLAAHPLYNQELLLRSQLLMKSALSASHNVLHSKVSNRYHPYMQPSPDRLREHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ER03</accession>
    <name>A0ABY7ER03_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="135" mass="15931" checksum="57E9509DC7AA88AE" modified="2025-10-08" version="1">MTRTYGRKDPAASLYSHLVKPSSDVFYDFACNLQEYCLNREKCNIVMTSFMVMPTSVMLLSVHQGFRALNLLILKLYFFYEWNKRERQVYLKKLQVTLAGLKELHNDHDSREDQPNQCRLTALVHLSLWTSYKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERH8</accession>
    <name>A0ABY7ERH8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF50">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="714" mass="80065" checksum="3ADAFFE5E9F8C28C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESP5</accession>
    <name>A0ABY7ESP5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="64" mass="7035" checksum="2F43C3CD9B013889" modified="2025-10-08" version="1">MAAMSTIKTDAPEELEEVNVTGISVEGQETSLLVDDVDIVMVPTELLLAARREGQSPEEEWVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETQ8</accession>
    <name>A0ABY7ETQ8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxynucleoside kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="16368" checksum="C0A0F39F2DBA61C2" modified="2025-10-08" version="1">MLFPKRCLSFLINTAGTCSREFNICFWPYSILRRKTVRQEVMKHNFTVCVEGNIASGKTRLLEYFRKFSGIVEKYLEDLHQLHEKWLVEKTPFKPTAPVLIVFCSLKQTVIYIFMDVFYDVVLLCFQKRRNIVLCVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUA2</accession>
    <name>A0ABY7EUA2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GRAM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF116">
        <property type="entry name" value="FI16631P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="128" mass="13678" checksum="AE1E889BA8513AB4" modified="2025-10-08" version="1" fragment="single">MEATPGEFPHQVTLLNNGYHSCGGSVIANDWVLTAAHCVDGQALSSLAVVVDLHDFNNPGSSYIWFDIAQIIMHNSYNKGPGGFPNDMALLRLSRSTQPDITKNIIELAPGGTSFAGERCTISGWGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWN2</accession>
    <name>A0ABY7EWN2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein quiver</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19632" checksum="A66E12E25CB535F7" modified="2025-10-08" version="1">MDMINKLFVFMVTVGSVEMNETATNLQCYSCFGTGGNNECEQFKTYKEAMDDNKSYSHYLKNCTPPYNQSCIIETFSVLGQTVSHIRDCSDGRFFSFNQTLQNQRNAYTRLHELDNSNETACVWDGQHLVCLSKCDGDFCNGPVLERKINAAAEQGVSLTVMSALSVVGLCLRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWX3</accession>
    <name>A0ABY7EWX3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aurora kinase</fullName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_027386</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="56"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR13206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="288" mass="32995" checksum="0CDACC148A210A07" modified="2025-10-08" version="1">MERVLQPVKEENRPHQPAPQGKPQPPASRPEHQPMSAGGSQQGLGQERKRWCLDDFEIGKPLGKGKFGSVYLAREKSSKYVVAIKNILRLFGYFHDNSRVYLILEYAPKGELYKELQRVKRFDEKIAAKYISQLASALKYCHSKKVIHRDIKPENLLLGMTANLKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGSYHDETVDLWSLGVLCYELLVGKPPFETESNTETYRKITKVDVRYPSYMSEGARDLIGKLLKHNPKERLPLEQVLVHPWITANYHSKENPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EX05</accession>
    <name>A0ABY7EX05_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26610" checksum="F5AD1A8E17B1BAD2" modified="2025-10-08" version="1">MDIPSMTKVSKVIKQLRYKRRDDDYPSLSSTPGPSTKKNKYNRHKTKPQRDLAYVEKHVNSCRTMISELKKLFDGQPALHIHTRAQEWRQELADVEKTLTFLKTVIAVVGDTGAGKSSLINAMLDHRNVLPTSGMQACTAVAEWFDELQILLKELTGQDGTIKKNVPDTTSDAYVSYCKVKAVYGRIDSFEILSKISTVIFWLGRNKVIKENNPEEFRRQIEIYIATQDSGTGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZL5</accession>
    <name>A0ABY7EZL5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="174" mass="20064" checksum="319D672A9011B504" modified="2025-10-08" version="1" fragment="single">ELRPKLSTEIRLFESQILHPLVGLQYASMKNTTSPVTVMMTRKSVVQMTEPKCNSHKQKRLQNMLVLVIFRKQPFNRRSSLESRVKIRPRTKFCHNFEQFVSLSQKIVKGRLRQYLLFWKGTIGANKNILSVIIINGYVITFVTKPTILVLKSNSSALTKKSFVEIAIVSLDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0K4</accession>
    <name>A0ABY7F0K4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25049" checksum="B8662CAB9D951D09" modified="2025-10-08" version="1">MSVYKAAILYGLPESTLRDRTLGLQPVTNKYDNLPSLGQPLTFTANEERQLVEHLTYVASIGYGYTQSELLSLATDWAITLHRKKQSDPQFASSWYTGFKRRNPDVTLNSQCSEQSARQSNLTLSAWGEANNVPLDVGCFRPLKNIYHSECQSYMRRNPGMQINHYSIAEISSKAYNKGVCAENLISALRKTGVFQRRRYSITRPAKTAPSAIYTIDHTCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2T0</accession>
    <name>A0ABY7F2T0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37697" checksum="EED6A27732FD5DA0" modified="2025-10-08" version="1">MNGYKHSRATVYMGQDTNLHASQQTDDLSLVMFIFQLFQSGFIFTAFVAGVICVGHLVLIRRKYCRNTTTLFAVVLSGFLHLIASVYMLTIAENYMKKRVKQGPPSVGSCMDYSMTAAFANGVVLVFIVHNVYVQNFKWSMSSCLAYAGTLGCIITGSFSIIKIVPQNSPLPVEQHSLVTLGTYGSQHFDVFLSVCQKNVYEERWSILVEYLVIYVPVMFTVLAALYTNRTKQTEVTITELKILSNKECNVSGFNCNCVKFNSVMVAILLYITFVLLIVRPGYILYAHATSGYFWDILPKYIGKVLIRSQYWNNEVKSNGYCDCKHKSKSLMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3H7</accession>
    <name>A0ABY7F3H7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HIP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_031289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF50">
        <property type="entry name" value="COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="C1q" evidence="3">
        <location>
            <begin position="101"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR16695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="234" mass="26438" checksum="D8814C0CE3958C6E" modified="2025-10-08" version="1">MEKRLSEVEDREIALTQQLLTQTAEIDALRATVARQEARIALLESTDYESNYKHATEPDVSDTDEVGQQELKHLESDWSDHKDIAEISTRILSQKRFVLSPPEIPVAFSAFLSIDLLNVSANQAIIFDNVLTNEGNGYHSHHGLFVAPQSGLYVFTVTIKHPTQSLPSHVDVVHDSKVIARLHCESNQYEQSSHSFIVNVKFGEEVYVINRNYNSEHFAGYMSSSFSGFLIWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F489</accession>
    <name>A0ABY7F489_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LECH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="27"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="139" mass="15073" checksum="A2CD8990D7F928BC" modified="2025-10-08" version="1">MVGSAKSADIVAAADAALELVVPSLPENYCRNHGGHLVNVGSKAEDDFLKQFMARLNATIFWMGLTDEISEGRWIWRDTGLEPTYTGWSPGEPNSFQGENEDCSIFYVTTNYAWADASCLGKFPPCCEIDLSNSGGVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBT5</accession>
    <name>A0ABY7FBT5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28222" checksum="0130D2A1C4696986" modified="2025-10-08" version="1">MAKGSNVILMRGERSQSFVYSLRLHVDISTMNLCNYYISSVFTVIYFVEVRGHRQVYYQKQTLNGATADVDASCVMQCAFQFSSFDSPVIEVQGAPCTCSTYGLEWYDDPTMSPGLVYLAKKRAYESFVPPVLVGPTECQTIPVPFIPDSGSSFTFVFTPIQLAHGYFLMDYYKDGRWRHLPADIVYPGIVGQVQEVTLAIYSDHCQVLLDNKFIGQFESPHKASKITKIVFCPENAFVEWHSVECKDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBW9</accession>
    <name>A0ABY7FBW9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial chaperone BCS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">BCS1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_001508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="8">
        <location>
            <begin position="197"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="396"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR19670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="514" mass="57369" checksum="422E2CD49FEEB538" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFD9</accession>
    <name>A0ABY7FFD9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="172" mass="17981" checksum="C43DB4AA589BCF66" modified="2025-10-08" version="1">MQSRFYQPRCYPYRSTTTSLDVCPCSPASTSPDVYPYRSTTTSLDVCPCSPATTSLDVCPSSTTSTSLDVDPCRPATTPTTASDDVCPCKSTTSNLDVYPCSTATSLDVHPPATTSLDVCPSSTTSTSLDVDPCSPATTPTTASDDVCPCKSTTSNLDVYPCSTATSLDVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFH8</accession>
    <name>A0ABY7FFH8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MOT12-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_001344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR19506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="496" mass="54404" checksum="E1B9293CE403E963" modified="2025-10-08" version="1">MVEIEEKIDHPCDEDIPLQSKESRGECSTNGGKGSEDERPGEEVEVTNILIDLSEDKVPDGGWGWMIVFGAFLVHALMGPVASALCNKFSCRFVVILGSAICTLGVLISAFMPDLPYLYLTYGVLGGVGRSFTYTPSLIIVGYYFNKKRGLAVGLATSGVGIGCFVFPPVVEIMFNHYGFEGTFLILTGVISNFFICGVLFRIKKMRKECSTKGEPVENLLPVSMVTRQQNLLSSQSAAKMSSSIEITANYKIEASKTSIFRRKLSHVKTAIKGKDKPKTEKEKKPLLELSLFKNFGFTALCLQLFLYTLAFNLTFVFLPALAKEKGISQLDGAWLLSVLGIFDGIARVAMSTVLDLKRVKPYRLIIYNGVMFGNAIVSIMLPSMTKFWHFAVMSGLFGLLSGTYISQKSVVVVDVLGVESLSSSFGLLLLFQGLSALIGPTVGGLFKDMLGSYDMAFYFGSIGIILGGLVMGVGNVWIYRQKRRQREADTQTTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFJ4</accession>
    <name>A0ABY7FFJ4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="83" mass="9535" checksum="4269F9CCD238A0E4" modified="2025-10-08" version="1">MFFEANIFKEVQMQGRYFVAIGMKCAFVRNVLSKIGPKHIISERCHTVVFNHTIITSNKTSEAVIIRGRQEMENVFTEGRNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGK7</accession>
    <name>A0ABY7FGK7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SI1L2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_001924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd06745">
        <property type="entry name" value="PDZ_SIPA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711:SF22">
        <property type="entry name" value="RAP-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="5">
        <location>
            <begin position="545"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="869"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="978"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1032"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1096"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1196"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1305"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1360"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1419"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1007"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1044"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1064"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1119"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1134"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1155"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1246"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1305"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1368"/>
            <end position="1387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR20086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1489" mass="165414" checksum="BA95559370D3D72C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHC5</accession>
    <name>A0ABY7FHC5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="77" mass="8948" checksum="5A95C479A12F9D14" modified="2025-10-08" version="1" fragment="single">MSDTACDCVRQSFREDKAGYVTLEVCVLFRYVYSQGMCTLEVCVLWRYVYSGVICTLQITKCIGKMIKAREYRVKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIK1</accession>
    <name>A0ABY7FIK1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045583563" evidence="1">
        <location>
            <begin position="22"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="139" mass="15845" checksum="1BD7BDE965B14E3D" modified="2025-10-08" version="1">MNVSMILRICLILRVIHEVSGGFIPVESRCAKTCSRQEMGWSFNCDGDNTTCDWQCAAQRKDCPEGLTYHCAADYEDFELHTGNINYLEECALEKPCKRDYTCISHCPDGYHRTDDSDKCVERASATQNEDAKDSFFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJT0</accession>
    <name>A0ABY7FJT0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="472" mass="53104" checksum="FCAB9359446B644E" modified="2025-10-08" version="1">MTVNPLAAPGKMPNASTACTGSVSTSGVTSPIDKETLRRQIVGLAVKNDFKPDDKRSPREIFFRDSTDHNITYRDIPKCVKSSSVTFDTALHLSSQIERPLRRTPRKVKADPLELKAHEESTMIRANKQEVLQNSIRRTKTTMDKSVDTKPPLAKPKLVRFRMDEHTIGDTKIPLVNIRAVSPGPTNGFKHTVKTDVSSSYEVRGNAIALKKEGLKGLVEYRDLCTESEKRQNSLQASLKIFRRRIKLKQDKFIQPNESTADDYVIHTARPTFGDTVSPLTPLPPGPAVDERGEPLAGRPLSSDEHVRILKSALHNRHHGGNEIIKAKETDLFDNSEMYKNIKCSYRLPENPNWSKEVSFKDMKDDSIPNVKTYVLQEDRMNPHTKFKKNNIQNAVTLNIHNLSVHNSITRVNGHKMRVGEGEVNFDPRFVDWLEDSLSNSRSLSKSASLLTDDTLEPCITPSVKRRAATKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKC1</accession>
    <name>A0ABY7FKC1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="325"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="440" mass="48770" checksum="BBFF6C48FDEAFB87" modified="2025-10-08" version="1">MPQGFPITEGLTMHQMPDPITTMTHTSVSISMHQPASSMVFVSMSGAQFSSLCDTMTTSIPGKHSSSSAGGIEMVIVSTTNSLPVSISHTSTMATSTVTVNSDYKLSEIVSRGGAEFWKNEAGTSKREIETELVPMRSDVLSVQRRSRQFFTLMEDDDEMDYGSNRPKFADDEPQSKNVLVDPLMGISKTMRRLTRKNDYGKLKMSTVMNKNPPNLDRGYESEPETDKMPVTLLDHVEKSGLRRISSHPELDELELMAQDNLKGNGDNNSEDLFENYALGKSKSLPTTPRVSPKLLRKNRTSNELESPSDSQNHGAGYSFLASVIGGLRVTKAKQEQQRKDAEQRLIEKKKQHDKKVVSDQAGLIVPRQENQVVMAGASTSSKTATVDTLLNSNMSEKVNETQSKSPPKKSFLTNVMNWSTQKQVDVSRKESNMWSPTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKX2</accession>
    <name>A0ABY7FKX2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR22843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="59" mass="6772" checksum="3DDEBDFCC755F975" modified="2025-10-08" version="1">MSSVKGLERCLLGRPAIQNLCFVKINTDKVICFDSVNHKYPNLFNDLRLLNGEYNISQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLJ1</accession>
    <name>A0ABY7FLJ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_016188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR22214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="247" mass="26979" checksum="20021A3B32088C6C" modified="2025-10-08" version="1">MGMGCKEIVAKRPSLCLDKRWCVSGQCVTSSRASANPKAGCEYGDHSPVVCQQHVTDDCPYGDVDAAQCATFMNDTIGPGNCYSQDKRDRCCDTCKQYYNASYSGCEYGDHWKDYCATSVVPPNVASQCSKYSTQCCQTCADYRAQGFPGCTYGDRDPNVCGGIRNDTTGMNNCYNTAVRYQCCLTCHNLKNDATPGCLYGDKNPNKCEQMFNSSRGLGSCYSLQAQIDCCRSCEQAKDATNIGNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FN78</accession>
    <name>A0ABY7FN78_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR23660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="166" mass="18246" checksum="1CF434042C2C810F" modified="2025-10-08" version="1" fragment="single">MFEAIQSITPGQSGKFKEMFHTRKLSVHGSVETCILNFSSVVTVFIEEKSPTDNHMQVPVGAPLHGRCSLSTGYSVKTDDIEFSECNPLLATAVQTIEKVRGLVWSPINAVFKQRHGYIIRDANKQQREAVSICETFSAGVISSMHGQFADNDDGSILTSMFFVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNK4</accession>
    <name>A0ABY7FNK4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PLPP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_037464</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF103">
        <property type="entry name" value="PHOSPHOLIPID PHOSPHATASE HOMOLOG 1.2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR23795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="167" mass="18874" checksum="2EE71612E294619E" modified="2025-10-08" version="1">MFYVNFNFFSLKFYIQRRLQVTFSRTLKIFLQFGLVFLSLICGLGRIQDNKHHPIDVIVGFLLGSSTAILVFHFVGIKVLTYVDDSDDLPSRSTNEPQDCCACGVTTPIIVEPQTPAPLLPNEYFSGMSNCSGSVLRHTYNLKLNDLPNVRRHMSTPITPSREVEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNK7</accession>
    <name>A0ABY7FNK7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MAP6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34999">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34999:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR23177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="296" mass="32650" checksum="B75B975EB87B86B4" modified="2025-10-08" version="1" fragment="single">MCGALSVQDHSRVLTVSVQDHSRVLTVSVQDHSRVLTVSVQDHSRVLTVSVQDHSMVLTVSVQDHSMVSTVPVQDHFRVLTVSIQDHSRVLTVSVQDHSRVLTVSVQDHSRVLTVSVQDHSRVFTVSVQDHSRVLTVSVQDHSRVSTVPGVSVSVQDHSRVLTVSVQDHSRVFTVSVQDHSRVLTVSVQDHSRVLTVSVQDHSRVSTVSVQDHSRVLTVSVQDHSRVLTVSVQDHSRVFTDSVQGHSMVLGCLQSLYKIILGCLKTLSKRDLRNGECTTESGSQDLSLIIHCLPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FP30</accession>
    <name>A0ABY7FP30_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR23887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="768" mass="86851" checksum="A8CD1D21AB16C9E7" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FP95</accession>
    <name>A0ABY7FP95_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DMTA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_037549</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DMRT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd14370">
        <property type="entry name" value="CUE_DMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005173">
        <property type="entry name" value="DMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF118">
        <property type="entry name" value="DM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03474">
        <property type="entry name" value="DMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="8">
        <location>
            <begin position="17"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="6">
        <location>
            <begin position="17"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR23880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="382" mass="41961" checksum="C00E93055CA7CE1A" modified="2025-10-08" version="1">MSHLYPVTEKGTRKPKCARCRNHGLVSWLKGHKRHCEFKDCTCAKCNLIAERQRVMAAQVALKRQQATEDAIALGIRACSGDPHIPIMTQGPLWGPGTVMPPESQQEREERFKREQMAMTQTKDADSDDDIEDDISVSDEDSKFPRPEEAQKRLLPPSPTPTEKIGSKSEANPFDRNTGNPIPKSGPFKPAAFTPGRLSNVDILERVFPLHRKSVLELVLQGCNGDLVKAIEQFLSAQDTIDAHGKSDTPSKTSPRYHPYSAPSNWIQGSSTHYSPSASTALDLKSAFKPLPMPQISGLHSAFLPGYTSLSSASSFPASFAAGQYSSPNFRLPLPHATYPGLHSYGGLFGSPFSILPYRAGEPRDLSKVTEREPVSPLTKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPE6</accession>
    <name>A0ABY7FPE6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nuclear pore complex protein Nup153</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">153 kDa nucleoporin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Nucleoporin Nup153</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">MAR_037691</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">MELC-2E11</strain>
            <tissue evidence="22">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the NUP153 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026054">
        <property type="entry name" value="Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013913">
        <property type="entry name" value="Nup153_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193:SF23">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08604">
        <property type="entry name" value="Nup153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="12" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="21">
        <location>
            <begin position="529"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="21">
        <location>
            <begin position="580"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="21">
        <location>
            <begin position="631"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="144"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="321"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="690"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="741"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1141"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="700"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="773"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="799"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="848"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1165"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="1193"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00078197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="WAR24022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1203" mass="123598" checksum="2F00DC1F8CB8198C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPT9</accession>
    <name>A0ABY7FPT9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="390" mass="44793" checksum="6E2A4E1117633D8A" modified="2025-10-08" version="1">MKKGKKKVKPADTRPAGKEKHLKDDAISADCDLWYRWSMWRMHLNEELAGAAMSMPGHKRSEMVTNITSSYYNRRESWVYGRQMKSLSSTGTCPTLPSVLSDNIYLVYGLPRVSIKQNTPKYVTEMHQSLHELDLVTKRSCTSFDAAKELNIQQEYMCVNGDVRKHIVSSESSIPEGIHNYSQNENDSQVRFKEQPSNEVADVVATSSTKPIHMNSNDKCETAIPKVSKSLEFWEKLAKRKNEIIELEKVHIVTKSDNSNERGAISCELLQNQQKLLKKTLPSKRSSKDLWRSVAQRKTEIVLLKENDRLAPNEQKQKTGQFWSFIFSKKKDILQMKRSGNKTESNDKKEVQEKKSSKDNVPKTFEDSFQKELADKLRKRRVAAENTGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRR0</accession>
    <name>A0ABY7FRR0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_038516</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="194"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="344"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="457"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="631"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR24847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="727" mass="83665" checksum="B8A8B3214B928C0F" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FT76</accession>
    <name>A0ABY7FT76_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MCAT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_011046</name>
        <name evidence="13" type="ORF">MAR_011119</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="5"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="105"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="204"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR25342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR25415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="299" mass="32789" checksum="09818036B797FA72" modified="2025-10-08" version="1">MGKKVNPVKDFLAGGFGGVCLVFAGQPLDTIKVRLQTMPKPLPGQSPLYKGTWDCAMQTIRKEGPKGLYKGMAAPLAGVSPMFAICFLGFGIGKKLQQKHPHDDLTYFQYWNAGMLAGVFTTAIMTPGERIKCLLQIQADGKTKKYAGPIDCVKQLYREGGIRSIYRGTGATLLRDVPASGMYFMSYEWLQHVMAPAGSDRSELSVGRTLFAGGMAGIFNWTVAIGPDVLKSRLQTAPEGMYPNGIRDVFRHLIKEEGPAGLFKGLTPVMLRAFPANAACFMGYELAMKFLHWMMPEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUE1</accession>
    <name>A0ABY7FUE1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="221" mass="24641" checksum="A2CB2F4DB48BF75D" modified="2025-10-08" version="1">MDITVTEDRPRGQATRSGRGDLSRPTNRESKGMDSRKREVSDCMQDILDRCRGSTDAEQILHKLIDKDKTMATVDYFCRHIQLYERHQACISSHHEEVSFCTQAAQKSFKSKLDAGAKMDVLIMGSCSFFFIARGCLTNTTEQFCGGEPANFVHTLMTGYMPPYCETHLPEDSTRGRWGSPGGTYNTGDGENGATTSHVRPFSILTVFTIILTVSLTNVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVD6</accession>
    <name>A0ABY7FVD6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ACHA6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_038528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="586"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="667"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="49"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="184"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="354"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="528"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR24859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="695" mass="77910" checksum="B64CF9D20C96279D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FY96</accession>
    <name>A0ABY7FY96_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="385" mass="44588" checksum="3D4CCD00D69AE6E9" modified="2025-10-08" version="1">MNLNIIAWNVTGIFSSATYLTDTLVKHSVDICGIAEHWLSPQNIHLFDNLSSDYCYHAVCDSDLYDISNTRKEKVVLLSYGKKYNDKIVPLNIDSDRLVGIQLQLSPNEYMFFFQLYLPCSNHSISLYRDHIDKLYDVWYQYSNSGVCVFLGDFNAKYIPNFSISNRDKLLSRFLDDCNTVPVNCLDMCTGSPYSFVSYDEKYRTLIDFICIPRELIDCISKCFVFDDSCLNVSRHVPVFLQLHVPNIVFTDNEAHVPNVCPNWRKANNCDIDMYNNCIERDRDILHIGACDLDIDGIDNACNMLAVKLSYYADTCIPKKRFMKFLKPYWNTNLKNAHKHMRALKIVWCADGRPRGGTNKMITDGWADYFRDRYTPSDIADDYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYT7</accession>
    <name>A0ABY7FYT7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="199" mass="22549" checksum="9AF86DE4D00402B5" modified="2025-10-08" version="1">MGCKCRRSKKDENDDKYIQRQYNGPARRKINMDIKVNSRNYDRDYGGRSFIAHNAGCAVNKPEHNTENVEALRESHEEHHEDSVMATERTWKDISVALDTVLKVTNISTSTPSTISQTLPYLLPGPTSQTLPYLLPAPPPRPYRNCSPPPRLPDPTVSATRPYSQTLPYLPSFSKPYRIFSPPTSQTLPAHTLVMRDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0M9</accession>
    <name>A0ABY7G0M9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="258" mass="29425" checksum="56795935A1239102" modified="2025-10-08" version="1">MYITSVLQSMFRSEIVFRERMDSIDEFKRSNMEDYMLMIRDFEIKKREVDPQKSDKPVVAIKADKLKVDMDVVRNIFKIQIEAIVDHVSNLLDQSTIVEIGAIVLVGGFNDCPLLQQSFKSKFDDHTIIVPNDADLAVFKGAVIFGHKPELISQRVSIYTNGIEIRVPFIEHVHKESYKIKDEDGKHITAGQCLVIVEAHVEKNYHAVPSTAALIFKVYYTLDPNPIVGMIYGETEIEVEVTKIVTGSLHRLKIDFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1P6</accession>
    <name>A0ABY7G1P6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045858568" description="Endonuclease/exonuclease/phosphatase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="37457" checksum="E8D5F3D90A3B9C7B" modified="2025-10-08" version="1" fragment="single">MKTIFGFKLMNLFLILNVCLEQFTYLPRIESDIVDFRSEGFLVCMIGDFNARSGLLSDFISVDQHISDDIETEILLNKNNLDVLGFPSERYSEDYTYNNYGHRFIDLCKSLDVHIANGRLFKDAFIDVHNPVYITVGAAPLPVVEKISNDISDDANNVKPTWNPNSLNDFINCIDQESVEQLSLFIDRTQVDSPCTSDLIDDITMKTGKILTDAADKCKLFKVKKKQNIFKSKTKPWFDNECKAKQKEFYGSKQKYRRFHSHNNFVSLKNHSKAYKKVLNSKFKDYHDCIAQKFKNLRYSKPKEYWCLLHKFSGERKEVLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2Y0</accession>
    <name>A0ABY7G2Y0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_014264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36531" checksum="7DF170C2F3193194" modified="2025-10-08" version="1">MILSETYKQTRHIILNSNHVVFGVPCAKEVKEPEVLQNQQQPISHGRRGLLAESYNIGWYILWSIKFNPLVFIENSIVLAFNFGIQDVIITGDFNLDMTKNASRSKVKHIVQRYGMAHMISEAINFTELSILLIDLFLVSNPEHNGCITQLDCTYAGGKERTTTPSYQTSTAVELPTNDYVMKQQLLLEKLALLIWSNWQAENLGSDKAYILNTFFQSQTVLDTSHIILNLSQNNVGVPCVLEVNEPDTTIVTNIQIIKPTGRHGLLAVQKTCHTYFDYNISFIKISTTAIKPIIIIINNNNNNNNNNNNNNTTTCETVREKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3S1</accession>
    <name>A0ABY7G3S1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="1">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="223" mass="25085" checksum="5E0B9C5A0CA8B285" modified="2025-10-08" version="1" fragment="single">IVMTKIKMFDRKRTGVGSQTLVTPTKCKCPKAQTPSKFHNSPAQSKAKKLVQKYKKGYRKSPGKIERIKEALKQVSTGVSVRKAAKNFGLSESLLRKRTTGEVGFMARNSHVVEMRKESSLENSRAKVTSMQLDDWFSKFYKFVSDLHLLDKPDRVYNADESGFSMGSKASKVIGPTKSEYPKKSPICLWSIQKAIDKDVLWKRTGRSLTTFFGLSPAQANII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3S7</accession>
    <name>A0ABY7G3S7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TLR1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042342">
        <property type="entry name" value="TTC22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16253">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16253:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="10"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="311" mass="36240" checksum="3558A27B4CF30647" modified="2025-10-08" version="1">MNIPHLPREKDYHVFVCHVNENVHEVRTIVTNLEKGGVKCCYDERDFTAGRSILENMLEKINESVHMLFVLSEDFSKSRFAKHELEEAIHQQIREDFSIIPLKIEPCDVPQILKNKTYIDCENDDITKVHHKIIEAVIDNEEDINELESIVKESYFMKNIHIYDFFPHITCLLLVLYLMLSLAVMMFMVYTMLDTSRTDSASGGFAILLVSVISPVVATILSMGCCCWKKQTKNVNLMVKDLFIRKCEQREEFQKRRREGETLNDYADRMINWLLCSKDIYLLDKPRQLQRGHSMINGAPCICLLLRDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5D1</accession>
    <name>A0ABY7G5D1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TOLL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_014238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045818977" evidence="5">
        <location>
            <begin position="22"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="768"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="6">
        <location>
            <begin position="529"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="6">
        <location>
            <begin position="704"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR28534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="867" mass="97942" checksum="39A099AEB9C7E871" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6M5</accession>
    <name>A0ABY7G6M5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="34" mass="3895" checksum="7A971AFDF463DF41" modified="2025-10-08" version="1">MAINKDDVIQNDNVIPEKRGRSRNGNVSGFYSNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7F2</accession>
    <name>A0ABY7G7F2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_012880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR27176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046289780" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="191"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR27176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="258" mass="28212" checksum="232A252455DF2FA5" modified="2025-10-08" version="1">MIGYNTAMYALAAATLVIAGQDELVKCTPGVYEIIGKADCTGYFLCVFGKAIEMPPCPPGSVFSSSSNVCVPKGSIYDDCKKTTDGSGSKTNESPDQGHPSPVERCAIGGGVFPHARECQAFYNCSVRKRDGINAHPVRLWTPFFVVCYKERTVKEDLCKVDENGRTQLFHPEKNECVSLDMIPREHGGMMPECGKKVDGFYLDDFGRCDRYVHCQGRKYIGTIKCAVGEVFDAMKGGCVPKEKACGPCGRLDHCVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G896</accession>
    <name>A0ABY7G896_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="95" mass="10188" checksum="52A9A2E1B7C37861" modified="2025-10-08" version="1">MESKTDLGSGARAFDQALEKTQSNIRWMNANVPVIATWLKDMGVEVKDKLGPTRGRNITECVLLVLEFCAVASARAASVARTDVLFPSSAESSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8A0</accession>
    <name>A0ABY7G8A0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="151" mass="17392" checksum="C8BD0A2DF08FA422" modified="2025-10-08" version="1" fragment="single">MGPLRECMVTPRESLTHNSLNYEDVKFVVIPFSRLQKQTVCLSLRLRGKRPIKPRNLGITSFKDICRQCVPRIRISGPRADVARREREVYRETLKEAAHEMSSHVRAIGPVPVLSCSEVVHFTFDYSQNVTIPHHRRQMGPMYPAQSKHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8D8</accession>
    <name>A0ABY7G8D8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_032917</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="116"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR30375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="43414" checksum="7A891108F13C1092" modified="2025-10-08" version="1">MACLQIEKETTGGGTSFSSVLNTIIIRIHLSKIVGSQRAGHGTNKALFLITDGEQTVKERDSLNHKLILLKEEGYELFTVGIGRNINKLMLKEIASEPTKDHIFLIRKFNDLKYIGDILSSTFNVSEGHIILKKTKDYGKCGISGSTEITEGTDNSKKITVNLGDSRLYQGDDEQVMPIVKGVNIHPNYTGVPNEHDIRDYDVAILDFGEDDRTQPPLNKYSLERLKSSKVLDGEAHGFTVGWGLSPSFTRQLPWVKQKQNRREIQSDFICGRQYPDLDTDRYFCVGNIRKEGDSCRGDIGGAYMAELRAKRYSAFGIAQRTYDCQEHRHFSIFLDLHHPSITEWALPILGRCNRLGSAEDEEKEAEKERAQKKTEETNLLKKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8W5</accession>
    <name>A0ABY7G8W5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ZN665-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_003437</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF111">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="124"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR29869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="260" mass="29606" checksum="54FD76013ACA458A" modified="2025-10-08" version="1">MNIHSAVKPHECDTCGAAFSRKFSLLTHMRIHTEEKQFKCDTCGATFSKRSNLRSHTRIHTGENPFKCHTCGAAFSQKSNLQRHTRTHKGEYLYKCRACNAAFSRSDTLLAHRHTRTHKGEYFNKCKTCNAAFSRRDTLLDHVRMNPLQREAIQSTLRTHIIIHTGEKPNKCNNCGASFSQKAHLQNHLRIHTIEKPYNATLDSTHERSLTSAISVVLLFLSHVQTHTGEKPYKCKTCSAVFTHGCDLQKHTKIHTVVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G984</accession>
    <name>A0ABY7G984_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_003487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="129"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR29919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="358" mass="40281" checksum="B340749552159D20" modified="2025-10-08" version="1" fragment="single">PPSKPFLQSKKIVQECPECLVGILGENLYYHVFCNTSGGTSQSIKIGDVEEEMIRQSNSEDIYINSRIIRKHDHMKTDIYTLEFSCSLDNYNDFCWISWTKDGLPYANGDGTDRIHKSSVIVFANVNRPSVHLSVKDELILNARETTKVTCTAKSLPLSDIVWSVKGDTQIHVCNKSNECEININPGNVNERRNYTCTAYFKFEKYGTSATSSFLAVWRGEGSSLTTHSEGISIEWLVIGLVGLLAVVIILTAIVLARKLFLEENTHEHPIVTAANVQENEIEELNEDPTYAQVDKTRRTRPETEECKAKGSGSELVYADLDIEHLEKARTLTSRQRETTPTVYDDVDFTRTKSGSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAR9</accession>
    <name>A0ABY7GAR9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TCB2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="79"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="150" mass="17537" checksum="DFC6D83683E0F879" modified="2025-10-08" version="1">MTQRYRAARLLWARRHLIWRRADWNQVLFTDESRFTVSHADGRLRVYRHTNERFAYCCIVEKNRFGGGSGNSIAQRYVTDVLNAYALPFIRQHGPGVTLMHDNVRPHVARVTTQFLQQSNVNIMPWPAVSPDLNPTEHIWDQLSTNYPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBJ0</accession>
    <name>A0ABY7GBJ0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetylneuraminate lyase</fullName>
            <ecNumber evidence="5">4.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_033834</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23296"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17122"/>
            <dbReference type="ChEBI" id="CHEBI:173083"/>
            <dbReference type="EC" id="4.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-sugar metabolism; N-acetylneuraminate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DapA family. NanA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.3" evidence="5"/>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF21">
        <property type="entry name" value="N-ACETYLNEURAMINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR31292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="201" mass="21761" checksum="0FD195BC83898CE8" modified="2025-10-08" version="1">MRYYHDAGFDGLFVNGTLAEGMSLSSEERMKTAEKWMRLAEGLPVILHIGTGNLKETQDLARHAESLGVDGISALPPTYHKPPSEELLADYLAEVAAAAPNTPFLYYEYDVASGLFLPSLSLGIPDCITSAYMGQFFRDVKYSVAKGGDITSAKAMFELISGVKVGGPRLPLPTMESRDMQLMKADLVAGGFIKESTVKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBK4</accession>
    <name>A0ABY7GBK4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAPC2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_034334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026828">
        <property type="entry name" value="SAPC2_1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057953">
        <property type="entry name" value="SAPC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14907">
        <property type="entry name" value="FI14130P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14907:SF2">
        <property type="entry name" value="SUPPRESSOR APC DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25825">
        <property type="entry name" value="SAPC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11414">
        <property type="entry name" value="Suppressor_APC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suppressor APC" evidence="3">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="507"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR31792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="552" mass="62833" checksum="FDEBA79C5B664786" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GCA8</accession>
    <name>A0ABY7GCA8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8306" checksum="7ED0EAEA447750E6" modified="2025-10-08" version="1">MQCGQSFVFRMFVLLIMATVGIMPFNSARIHNRTSLTQLGRYTPKGSPHGLGNWHLYGDYLSNTTRTTGYTFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GI80</accession>
    <name>A0ABY7GI80_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_033393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="336" mass="38987" checksum="AE192EC7D4BC2E3B" modified="2025-10-08" version="1" fragment="single">MDSDQSTYKTLVLVMTRYCFLLCLRVDAQRNADYICLACMLIYVHGVGKCPKVDLFVNGTKRQFPSAWLEKYDWLRYSYTAHSVQSPVRICIFKGNETFISTPVSKWSDLGKYIKRHVKDCSSHHRCYASAENFMKIAKGQIRASQHTNLLSLFETRWASRADLFNIFKAAYTNMRHTTGYDIQFLKIQYTAHSVQSPVSICIFKGNETFITTPVSKWSDLGKYIKRHVKDCSSHHRCYASAENFMKIAKGQIRASQHSNLKAEQRLSTEIDIWASRADLFNIFKAAYTNMNVLQGVLPLNKLLQKREAARESSESYSHGFNRDRERFRREVGCWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAH0</accession>
    <name>A0ABY7DAH0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SSPO-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_006077</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF48">
        <property type="entry name" value="THROMBOSPONDIN TYPE 1 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Spondin-like TSP1" evidence="5">
        <location>
            <begin position="136"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ93606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="391" mass="43256" checksum="5B683898F61DCD3F" modified="2025-10-08" version="1">MASLVHKPNWSPWSPWGDCDVKCGTGRRERTRNCDSPAPRPGQAGCPGDNKDYGVCTEKPCVCTFNMETYENIFGYEPSDQIGWIERDGTFGPTSPEEDVYVDDTMDEGVVVHVSCSNCTCDDGEISCEIGECEDCTYTEWSTWSTCSKTCDVGQTTRTRRLRNQSSRRPSKCKRVLTEREDCNLDRCPAPSECEGGMVWSECANRCPHTCMDVRLGTCVDDDDDCIPVYAETERWTVPKIQSAVTGTSGGHGASVVRHVDIQPGIDTVDGSWNSWSSWSSCSRSCAGGKTNRFRQCNSPLPQCGGKPCKGDNSESKPCNKNVPCCDLTSWSVWTDCSVDCGTGTRDRSRNYVEAGDQELCHDTLRETEVCKLHDCDIATINVFVSQRLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBN7</accession>
    <name>A0ABY7DBN7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">U5S1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_007169</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="130"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAQ94698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="936" mass="105876" checksum="E58FBF718CB5BDFF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDC0</accession>
    <name>A0ABY7DDC0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_028329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="102"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ95639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="479" mass="54703" checksum="0483886D23EB5DF5" modified="2025-10-08" version="1">MATADVEGSDLKDTSNSGPKGHDRTNGSARLGKRTEEEIREEHRTLRVLRKLEGHQSQIIQVLSSIERVVCRTTSNEGQEIDNHPLDQSDKSVDASSLNVETTQEKKQIAELSQQLDETKKTITNFNKTVEDNEKQIDVLKGEVRQLSEEKDQLSGDSETNKARLEELQKKVTDKNEKIKKIEEEKRCSCLEREIDTKSAEVDYLNREKDDVYAEMNAQRHLQEDHSVYAETLELATKGKESSTDIAKKHKELDDAKREIEKFKIEKEEEKAKKQEELDLAKKEIEQLRKAVKREEDEKEKSYDTPVKINIKAKGERTCDVQGMVCTGQGIFVLTDWDNKTLKAVDIIGKSVLSVLQLDASPFDITQLKANLLAVTLPEARQIVLVQLLSNGNLNVFETISVTEKCFGIAVLDPGHIIVVNSNVEVYDLQGNRSDILVDMRDESMKDEFEELHTREPFDCDKNVLLHQFLVRVFNYFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DEQ2</accession>
    <name>A0ABY7DEQ2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">OPSD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_028822</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0157">Chromophore</keyword>
    <keyword evidence="8 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="447"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAQ96132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="493" mass="54937" checksum="204F0DCA5B03BE10" modified="2025-10-08" version="1">MDSTTELSVVTFTSTSALLLTDVTTEVGIDVTTHIFDTYNVFIHPHWKQFPLVSDAWHYTVACEFYGLIGGIFGIMSINTMVMIAIDRYMAIARPIHVAKSMTRKKAFIMIVTVWIWSLATCLPPIFGWGRYIPEGFQTSCTFDYLTRTDNNRTYIFFLYVLGFAVPLSIIITCYALILRAVNKHEIEMKKTAKKMNAEIRTNQEDKRMEIKVAKIAMTILVLYLLSWTPYATVALIGQFGNAKFVTPFWSEIPVLFAKASAMHNPLVYALSHPKFRAAIQGRVPWLLCCCEPEVAKYAGRASTDRDRNTSRRSTASVAGGTSFDSEMSNLSDVTTADIDFRLRKLEEKSVKTNKSSRRNAIRSKSVEDIDDIPAGRIIQDLTHALCEVASRDKQGTRPLYLPTNVIQKDGASGQASKHTSDGVFVLDSSNLPELAKYLVQFSELNRPSSGNVNRAMDMSSEAPGEHKAGDGGAIPKQRVNAGNNSETDEAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DEY9</accession>
    <name>A0ABY7DEY9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ95181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="269" mass="29951" checksum="08CCF6D70FA84D09" modified="2025-10-08" version="1">MGVDISTYRARIGTFSGSTGVGVTHEECLVNFTFGLKTVGAVMFIGMLLIMGGVEQNPGPPKKEPSTEKKQNTAGEDRIGSIIIGSRHNLRTKGCKRYRSFATLFSTPRHRVDRVVPSNFPSSSSPLCQRTENSSDSYGELHLQSIFKPIFHFFGLTGRVNKQISVSEARILVEDNSSSGIQPTEAPMMLLRGLLSMNYETRDAYTFPLQDSQPQVQHGQRTNRVRTRKRVEVSSPSDLFMATFYCCDPMLQNLFSPYKSQKGVILVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFL9</accession>
    <name>A0ABY7DFL9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Histone acetyltransferase</fullName>
            <ecNumber evidence="2 5">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_029147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2 5"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF82">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="6">
        <location>
            <begin position="87"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ96457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="353" mass="41087" checksum="C88E00182CF92FA3" modified="2025-10-08" version="1">MKTEDQEETMLEIGDHYLVQRNDKSWQDQHSKIRDVKVMSTDLSDGTDRKLTRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYIDKVQIGRYEIDTWYFSPFPEEYGKQSKLYICEYCLKASVCTASHQARRSTGREPCLCSRLTIYCQNLCLLAKLFLDHKTLYFDVEPFLFYILTEVDRHGCHLVGYFSKEKESPDGNNVACILTLPPFQRKGYGKFLIAFSYELSKLDGAVGSPEKPLSDLGKLSYRSYWSWVLLEIIRDVRGTLSIKDLSELTSITQHDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKRPVLTVDTTCLRWEPPRKHKISKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGV2</accession>
    <name>A0ABY7DGV2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_029224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ96534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="583" mass="66955" checksum="7BFF8F374DEA1F67" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMR7</accession>
    <name>A0ABY7DMR7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VNX1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_022556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="4">
        <location>
            <begin position="145"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ98183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="588" mass="65824" checksum="B31294D9C795110E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNP3</accession>
    <name>A0ABY7DNP3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510:SF3">
        <property type="entry name" value="ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="395" mass="44413" checksum="580E535B386B5051" modified="2025-10-08" version="1">MPLEFVHSPTQQTFDIGSRLTRLLTLLFSLVILFNTIFAFSVLVNLKSLDTCGKIYRGLQSKEYDLAGSRVFQPQEPRWISSDIKRLIRRRKRLYKEAKRSNIPSTWRKFRELRNLIISKIREAKALHIDSISKSLLEKKHSKGWWSTIKQFMSPNSGSLSIPPLVVESGIIHSNADKADAFNTFFANQTHLTEPNSEPVPPTYHISSLLATVVFRPSDIEPLLHGFEHARVINETQRGKLKGLKGFEGRSSIRQEYVCHLTKACPVAKDSGCEDSSVCATTSIWFINSPHSVRTYSLFMGDLRDAGLDASHIMYMSGHRNEASLRSFTREPSADQKRVMSNFIHTMNAGRLPTAAFSSGPAISFLLGPPTYSLVPRPTVSVNVPFPRSESDDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPP7</accession>
    <name>A0ABY7DPP7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_024047</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core" evidence="10">
        <location>
            <begin position="223"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon-binding" evidence="9">
        <location>
            <begin position="427"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAQ99674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="524" mass="59250" checksum="0D523321C0A55440" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQB9</accession>
    <name>A0ABY7DQB9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_024270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ99897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34736" checksum="1095DD8EBA29A96F" modified="2025-10-08" version="1">MSTVNNTTSGNESVVFRPSSGYDIPLYGLKNGVFYYIHGLAIGCLVTSLTCALLAIVFSLRQNNVRNFFSSWSKSERFIVYMATCDGLFNLTHLIDHVHITIVRDYVHPKALCAFYGFNLSFFIAAQQLLVNIIAINAFMLMFYNRHLNFGAGDWKLFLWTFGAPLVGATVAVAFEQYGPLGIFCFFDGVKGRLGELFFTTVPLLIILPVNCILYGLTFGKLHVRAKEIQQTLGPKSTTQRATYRAARSMSMFWWALALHGAWGQISRPVPNIFFYIVPIFTNLGGVFTLIVFIVIRRKPANSTGGCTIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQC0</accession>
    <name>A0ABY7DQC0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IQCH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_023285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056855">
        <property type="entry name" value="ATP-grasp_IQCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038752">
        <property type="entry name" value="IQCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14465">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14465:SF0">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24923">
        <property type="entry name" value="ATP-grasp_IQCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IQCH-like ATP-grasp" evidence="2">
        <location>
            <begin position="626"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="893"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ98912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1025" mass="115440" checksum="12E29F5E4060EBCE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQK3</accession>
    <name>A0ABY7DQK3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C1QL2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_023549</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF33">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="107"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="307"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="478"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="617"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="841"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="795"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="805"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ99176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="978" mass="108031" checksum="37A77952BBE099E4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRQ5</accession>
    <name>A0ABY7DRQ5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MEG11-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_023733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="629"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="743"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="958"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ99360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1167" mass="128971" checksum="11860560405166BC" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRX0</accession>
    <name>A0ABY7DRX0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="150" mass="17164" checksum="59C1B0E433C64AC5" modified="2025-10-08" version="1">MKPERLMDKGVSFVSDLIGNKRQTLLQESNDANKTIGTVVKVLRECYAKKSLGKVCNLSEHKSYRQLKSPEEMRLALECDTIPGPFLKQRSEEWFEMRKTTKVTGSVAHIALGLESLNKQKVFIESVLSNVPHPEPTEQQQRAMNKWFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUR8</accession>
    <name>A0ABY7DUR8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_008035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="82" mass="9333" checksum="F977A6C20007B221" modified="2025-10-08" version="1">MVNALIYIKYFMRQPSTISKLYFKGSTLAWNLFKRCTLNNCNLDCPFSDDTVDTVIFSSCTGSSVIDRLLLNCFSFPNILTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVM3</accession>
    <name>A0ABY7DVM3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TYB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_023363</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymosin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.520">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001152">
        <property type="entry name" value="Beta-thymosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038386">
        <property type="entry name" value="Beta-thymosin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20940:SF1">
        <property type="entry name" value="CIBOULOT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20940">
        <property type="entry name" value="TETRA THYMOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01290">
        <property type="entry name" value="Thymosin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00152">
        <property type="entry name" value="THY"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ98990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="209" mass="23848" checksum="20A7DE4913B2B5A8" modified="2025-10-08" version="1">MSVDHKTNPALLKDIESGTNLKHAATQEKNPLPSVEDISQEKTVQAIPNFDSSQLKHVEPQEKTGWKESISHDKATEELGKFDKSQLKHTETSEKNPLPDQDVIEEEKKEVEHRRSIGDFDRSLLKQQRTEEKIEKKEVQLRDSIGKHDRSSLRKVETNERDALKEIVAQEATHKGIESFSKDNLKHAETVEKNPLPTADDIKKEKTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVZ8</accession>
    <name>A0ABY7DVZ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LIPA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_008178</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd09565">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057892">
        <property type="entry name" value="LIP-1_CC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037621">
        <property type="entry name" value="LIP-1_SAM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029515">
        <property type="entry name" value="Liprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587">
        <property type="entry name" value="LAR INTERACTING PROTEIN LIP -RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587:SF20">
        <property type="entry name" value="LIPRIN-ALPHA, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25526">
        <property type="entry name" value="LIP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="735"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="448"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="589"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="887"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="589"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="889"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="939"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR01620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="948" mass="107656" checksum="FD8BDAD165E30756" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZN9</accession>
    <name>A0ABY7DZN9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S13A3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_009543</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR02985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="299" mass="33120" checksum="759D3D66250F9FD1" modified="2025-10-08" version="1">MRARSVISHIWALKSIWVTVLAVLLPLNLVLYQSDSDEPLKSSEELRSRCAYVIVVMAILWLTEAIPIPVTALMPIFLFPLTGVLPASVVSATYVSDTTMLFLGLMLTTWFLSMWISNTAAASMMIPIITAVSSAVREVKMKSGVHSGHENEAYDMEGIEENNGVKSKGNKYVINKQTGSSAQERKSTRETTKGEEQKENLRELSKSEENELRRLSKGLALSVAYGANIGGIATLTGTPPNLILCTKRPGRLPYFLRQMDGFRLSNVFDYSVYWLAMAGTRLSQAEVKVVTSYKKNTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E077</accession>
    <name>A0ABY7E077_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L27a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_009936</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027386">
        <property type="entry name" value="Rbsml_uL15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="8">
        <location>
            <begin position="72"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR03378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="147" mass="16589" checksum="07FCEC5A72ECDC61" modified="2025-10-08" version="1">MTTSKKKTRKLRGHVSHGHGRIGKHRKHPGGRGNAGGQHHHRINFDKYHPGYFGKVGMRYFHKTQNKFFCPTLNLDKLWSLVSEQTREKYANSTDKAPVIDVVRSGYYKVLGKGHLPKQPVIVKAKFFSQSAQKKIRQAGGACVLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0Q4</accession>
    <name>A0ABY7E0Q4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_010133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="54"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR03575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="154" mass="17298" checksum="E4B84594DF92DB6E" modified="2025-10-08" version="1" fragment="single">DRNPSRTLAAGTEVLQKKFAPDHKEENKKAVVLVPAGTMVKTFQAYLPTNKCHRLYSCVHCRAHLANHDELISKSFQGSQGRAYLFNSVVNIGCGPAEERVLLTGLHAVADIFCECCKTTLGWKYEHAFESSQKYKEGKFIIELAHMIKDNGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1M1</accession>
    <name>A0ABY7E1M1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TAD3B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_010278</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="314"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR03720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="412" mass="46377" checksum="E1DBEE81C9E50367" modified="2025-10-08" version="1">MKGKGKSQDKDCPLLFPDLECIDHVKLCPRYTAVLSRGEGESIGLEELDGIQVDLETLLNSVGKRLKVLENEIQILQNWQEKNGDIKPLQKAKGGKVQPETPGKRGKGADEKPCKKFKDSAGKPVMPVATKLKTKIGQIKVPEFDRVDSPPVEISKLPKNNAVNKFWASVEPYCADITQENLKFLEDLLRSHEDDSEYLKVPPLGMHYSEKWAEEDMMEEQKQGAKISDKRSNGITPESNGASGLLKTADAGLLDESPFGPLTQRLVSALIEENIMAPIDDDMDTDYTENESLNESAAISPKELAKQLNLGNTAHLEKRIKRELEEQAKQAELRDICAHNLQATKRLYKLAREEIDQQELRRKLSTSDTEVMEAYRKIQLAKQKKKTPTKKERETVIKVLKDREPIVKALDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1P5</accession>
    <name>A0ABY7E1P5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MEGF6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_008989</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047037486" evidence="5">
        <location>
            <begin position="18"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="6">
        <location>
            <begin position="92"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="636"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="640"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="652"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="670"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="686"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="713"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="746"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="774"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="808"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR02431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="852" mass="93595" checksum="340D827D248E1672" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1V9</accession>
    <name>A0ABY7E1V9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S17A5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_010551</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.540">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027378">
        <property type="entry name" value="Nucleotide_channel_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="615"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR03993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="644" mass="71257" checksum="FB3186562B4630C8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4Q0</accession>
    <name>A0ABY7E4Q0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HARB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_010331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="248"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR03773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="319" mass="35213" checksum="18E93B388B0D7E3B" modified="2025-10-08" version="1">MVLRGASLESSLDGVKGRLPWIQLGWCAGAPPLDPAWMVLRGASLRSSLDGAPPLDPAWMVLRGASLGSSLDGVQGRLPWIQLGWCAGATPEDPAWLMALVFLGGDGNRRRHNIPRVFRDRMNPLDVMNDHEIIKKYRLDRDAILEICAQTQQHLVRPTSRSQSLPVCLQVLVALRYYATGSFQSVLADGHGISIRSVSRSIHAVSKALTRQVPRQIKFTTTRAELTRTKQLFHDISGFPNVIGAVDGTKGFHAINGQGICSADNLFINIVVRWPGSTHDSFIWNSCECNAWLLGDSAYLLRKYLLTPLPTANTEAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4R3</accession>
    <name>A0ABY7E4R3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OTUD4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_020362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd22755">
        <property type="entry name" value="OTU_CeDUB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="177"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR04993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="341" mass="39189" checksum="CFE5535164A50348" modified="2025-10-08" version="1">MTIVGSIFPEHSPWDSLWSWQPGHRQPHWNSFEGWRDHASHSRTEIEIPIQIVDSDHFDSSDEWSDVDDYDMNNSSRRASKRSRDETSKFPTENDELLAASLNLDNYESSDDPFRRNLRRKPLREETRSSSYNTRSHGVKSSETICIDVDDDEKEINGTSNYSVYQYLKGFLNSQGRQIDGIKGDGNCFFRALSKIIYGNQKYYNEIRQAVVDVIEKHPKKFEAFTDGPISEHIADIRVDKTWGTQTEIYAAATLLNRDFYILSPDNTGETYRWLLFQPQVKLRKTNNLTGCDCCITICHTHGNHYDRIAPLSGKCNCELGPPEMSGIKGQIDLTSEDEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E967</accession>
    <name>A0ABY7E967_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="189" mass="21598" checksum="F6FE3E7B0B387D51" modified="2025-10-08" version="1">MTLSSWIYIGLSSRPSFTKYPMLPNGFLMEELGSTIVTHVSTGLVVGFKMLKQTRHVTLCELFVIPTFKSTDSASYCEGINSFVLPFFFHSEVLSFQGKLSSSMESNIQDERIYSVKVICGVCKYKDTDVEVIADVVDQTDELNLKYLADIEHSDTKRPQISEKLNKRRNKNRVKKPKTELVWTLRNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9K9</accession>
    <name>A0ABY7E9K9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ANK3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_020458</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="880"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="924"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="970"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1006"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1044"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1078"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1117"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="252"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="387"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="516"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="661"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="10">
        <location>
            <begin position="883"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR05089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1271" mass="144162" checksum="B343EF289630D16D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAG7</accession>
    <name>A0ABY7EAG7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="120" mass="13123" checksum="D0542903CF7531B6" modified="2025-10-08" version="1">MEYNPPPNPPVIDAFNTITDYLMIENSTELLTCRSTGGNPLASLAWSCYSGIQSNPNISGGSVSRSVQFTARRNQDNTCTCTATHEAGPLQQATLDVNIMCKYPFNTKIQSGRYTSGHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAL9</accession>
    <name>A0ABY7EAL9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-dependent DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21867" checksum="366B662E944931D2" modified="2025-10-08" version="1" fragment="single">MASPSHLKKCVPIRAVTTLFLLIKPAFITVERTMFPLVLAYAITSHKSQGGTYEHVIANLEKPSQVTSVCQAMCTQYSAESHLDKDKIKGINEALLEMNNLQDSFDWEHRFPNETGAIAYLNIRSLKAHHTDLDNDPNVQMLQLRTGKVIIAGDFRNIDPDDSRLRPLTTEFNMCQVILQPTHIHGRTLDHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EB40</accession>
    <name>A0ABY7EB40_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha 1,4-glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830:SF1">
        <property type="entry name" value="ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830">
        <property type="entry name" value="TRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="52198" checksum="1F303D106AEDCE39" modified="2025-10-08" version="1">MSNLLINIFYNVERDWLSCHLFGLVRKVEPIVGRPGTMVWTFKYARNYGAMQKKSSQLTPLTLAMAYPFRHKAVDVFLSSGDKRMFEWSAKGQNQCHENVTHTTDGLINPVSTSDLKNWRFRERRLCEPFSLETEKKPRSRFSLKCNGSFPEALYTTTDDYNDIFTVNFNDSCLATYIKHCCHDDKPVPNVIHYVWFGDMELKYFNFLSLMSALRFQQPCLIIVHGPTLPHGPYWDHFLHLAPPIVHVARERPTQAFGQPLFAKEHASDLMRIEALMEYGGIYLDFDELLLRPLHPLRKYPYTQGHEMHFSMGSQLVMAARDAPFLRMWQVLYKIVKQVQMYYGYRDDYRRIWAYNALWVPNTLAKKHPDLIHVEGYNFTRPSWKNVKLIFDANYDWSSNYGMHMYARWYRRPIDVTSMRTLNTTVGSVSRYILLGNKELCINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EF30</accession>
    <name>A0ABY7EF30_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Guanylate cyclase</fullName>
            <ecNumber evidence="2 14">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MAR_021140</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">MELC-2E11</strain>
            <tissue evidence="18">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2 14"/>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001170">
        <property type="entry name" value="ANPR/GUC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00255">
        <property type="entry name" value="NATPEPTIDER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="421"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="807"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WAR05771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1007" mass="113544" checksum="A92873CB1AFF9FEF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFB0</accession>
    <name>A0ABY7EFB0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CCTP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="200" mass="23017" checksum="F31C6142A32696AB" modified="2025-10-08" version="1">MASYMSELDHLVNPMSNHVISAEIHNQSVNSMALVSARLTAEAVEIVQMMVTNLLCLTAQAVDLRRLRNLAMEEADKLREQYPEATNLLEKTEWYDLMFLCDERIAALKEASGMQVTKETAEMMVYQRMRNIYKRTCNGDMDASKYMGKGTIRMYNFIRKELDIPFYFGQQAIDTWLGRLLTAVQSRSVEDVLFDIFTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFE7</accession>
    <name>A0ABY7EFE7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="208"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="417" mass="48398" checksum="49455B650B83F54C" modified="2025-10-08" version="1" fragment="single">MNVEEQLSCIKDLCRQKILHVIQSLENARTLNITIELQEILRYLLQLSSLTCIRSCIVFVQEALQILEQLPTENEISEIEVCKRQGRKYDIPGETLQYLIESGLRVKEISELLNVSKRTVERRMEEFNLSIRQTYSNLSDNDLRQEVEELCSSFPNVGYRTIQSLLLSQGLKVQELRVRQAVRECDPCGVLFRKVFLTSCRIQRRTYSVSGPQALWHIDGNHKLIRWRLVIHGGIDGYSRFPVYLNVSNNNRADTVLYAFLEAVQQFGLPRRVRSDKGGENVLVAEYMVEHQPIVNRPFIAGRSVHNQRIERLWREVWAGVTSLYYAIFYGLENEGILDPTSEVDTDVYGIDYNPETVLFHQESVEVPATMEIGDDHRQRIQDILQKDSNNLGVDIYKEILEFWTLRQHPIGQVDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGD9</accession>
    <name>A0ABY7EGD9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SC6A3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_017955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR07997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="103" mass="11251" checksum="5D1B383A4F651806" modified="2025-10-08" version="1">MDISANVSAIYNGDYVSGSHDSSSTGPKVVRETWSGRFEFLLSVVGYTVGLSNIWRFPYFEKRNGGGVALIPFLLFLVSCGGPLYYIEVCLGSPPLMSGIYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHH0</accession>
    <name>A0ABY7EHH0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019316</name>
        <name evidence="2" type="ORF">MAR_019391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="103" mass="11598" checksum="BDEB6908F9502026" modified="2025-10-08" version="1">MVGGLLEWGAPDVLAEKLQWELKTQIGENFSYLWYRFGPDNGGFLLFTSCERYTFSAVLKPESLWRSDSSTSANFSVCSSQSNSARLYLTYFLIEAGDTGNCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJ21</accession>
    <name>A0ABY7EJ21_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="67" mass="7891" checksum="CF0657CFA38DE88B" modified="2025-10-08" version="1">MICWIALDINQQTVYHRHMNIHSIGDTEQTVEIRHINIHCIGDTEQTVYHRHMNIHSIGDTEQTVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJ70</accession>
    <name>A0ABY7EJ70_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CHS2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_035116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055120">
        <property type="entry name" value="Chs-1/2_IV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF42">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23000">
        <property type="entry name" value="ChitinSynthase_IV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="877"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="918"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="948"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="981"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1146"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase chs-1/2 N-terminal putative transporter" evidence="6">
        <location>
            <begin position="210"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="643"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="643"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR10040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1179" mass="133357" checksum="8D3ED14EB05957D7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELC6</accession>
    <name>A0ABY7ELC6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_035868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="50"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR10792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="229" mass="22921" checksum="6AF0E83D6FE1A57E" modified="2025-10-08" version="1">MERAQRESLLLNTPDIPISRLPKSAITDWSESGGGTINGADGTITLAAPLSEASGVGDTVVTLTANSGGTVTGYTVTGTPDAATISNVGIVTLTTTVDYEANTELVLVIIATDDTPATGTATVTVPIGDVAGPPFTTTTKELCVADGLGPDATFYVDPTTGAVTTASGVTLDKATAAEHTVTITGAVTNGESNDLTLTVKVGDCSGKEKMAAALGSLLLSLLAYTILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELL6</accession>
    <name>A0ABY7ELL6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Heparan-sulfate 6-O-sulfotransferase</fullName>
            <ecNumber evidence="7">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_035956</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>alpha-D-glucosaminyl-[heparan sulfate](n) + 3'-phosphoadenylyl sulfate = 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56604"/>
            <dbReference type="Rhea" id="RHEA-COMP:9830"/>
            <dbReference type="Rhea" id="RHEA-COMP:14621"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:58388"/>
            <dbReference type="ChEBI" id="CHEBI:140604"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sulfotransferase 6 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010635">
        <property type="entry name" value="Heparan_SO4-6-sulfoTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12812">
        <property type="entry name" value="HEPARAN SULFATE 6-O-SULFOTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12812:SF0">
        <property type="entry name" value="HEPARAN-SULFATE 6-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR10880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="114" mass="13512" checksum="A7C49EF62CF3E2CB" modified="2025-10-08" version="1" fragment="single">NSTFPQLQEPIETPLKNNYDIDKDLIVFLHIQKTGGMYLNERFRTNLKLDFPCNCKNVPCGCLNKHHRMWMYRSAFSGWTCGLHADWTQMHSCIPQLADKVDKEHRERRYESIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMS5</accession>
    <name>A0ABY7EMS5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VRTN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_035187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd22791">
        <property type="entry name" value="OTU_VRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047273">
        <property type="entry name" value="VRTN_OTU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="1735"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="640"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1180"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1266"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1349"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1432"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1474"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1515"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1559"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1599"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="664"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="1744"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="1763"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR10111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1774" mass="195173" checksum="2A091B2A291CD958" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENT3</accession>
    <name>A0ABY7ENT3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F210B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_025685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1279" evidence="3">
        <location>
            <begin position="435"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR11505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="538" mass="59468" checksum="4111B925F345A156" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EP11</accession>
    <name>A0ABY7EP11_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NBEL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_035863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16057">
        <property type="entry name" value="DUF4800"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="2">
        <location>
            <begin position="360"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="1">
        <location>
            <begin position="454"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR10787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="571" mass="64986" checksum="BBB35F9847DA309F" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPX5</accession>
    <name>A0ABY7EPX5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GEM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_026090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF6">
        <property type="entry name" value="RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR11910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="409" mass="45756" checksum="F4CB56347E7C75FE" modified="2025-10-08" version="1">MTKKAMNADKNERKHSVPKIRHEVSNDVKTDHEERTVADKNQRKIQILASEQGSHSSSILTPTAHHGRSSSFRSRPRPKLLNVDGDRPRRSSLPPPSANLLSVSFGNIPKHKETSDEQPLQRVRSFKTTSKGGIVNRGDSFKRSSNSINSTGSAMHSEHGGARSHNNSRQRINSTQSRDSDTADSTGSMDTVIHKVAMLGDKGVGITSLTNQFMTSEFVAFETENDDDETDRHVTVLLNSEETTLNIVDRPINLQEMSSQSFDAFAVVYSITDMASYQAAVDILYLIRHQLAIQDKPSVLIANKIDLVRKRKVTREEGRSVAKQYTCKYCETSAALNHHVDELLVGILSQIRLYKTPGLQMDPPSFDVRPSQKKVAKCSMPGPKRLLNFIFRKKTMQPSCHECENLFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUR9</accession>
    <name>A0ABY7EUR9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CTR4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_003783</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF4">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="7">
        <location>
            <begin position="519"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR13678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="618" mass="67969" checksum="9967CC37FCFC033B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWU9</accession>
    <name>A0ABY7EWU9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GBP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_003832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GB1/RHD3-type G" evidence="5">
        <location>
            <begin position="381"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR13727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="495" mass="53669" checksum="A5B620FAD84B55A9" modified="2025-10-08" version="1">MASNGAPTDSFEHPSKAKQTQTRTDDPSKAQIPDPASQTVLTEGESPSQERQVRASSDASASMELKSELECVDQASKENPMQINPHNRPVIASDDHPTEMSKSKDFELSSEMELSQSTPTDNSNEAPPITTNDPAPQPVLKEKESPSYQGPVIASNGNPIASTCSELKLFEQSSKVEPTQTTSTDNPNEASPMTTTDPAPQPVFTEEESPSSQGPVIASNNTSFEASAKTDFKSNLEYANQTSKREPTQTTPTDNPNEASPMTTTDSASKLEPTEEESPSSKGPVIAFDGNPTVSPASSDSKLCEQSSKVEPTQARNTDNLNEDPPLKEPVSSQQQISQEDSYVSTHDYNVFKTPQCLISTREDKVLEVCGKVLDEISRIDKPCVVVAIAGLYRTGKSYLMNRLAKAESGFALGDTIESKTKGIWVWCRDHPEQKDTVLMLLDTEGLGDAEKGDANHDNHIFTLATLLCGTLVYNMKGAFDQDAVNKLTYPLVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXI1</accession>
    <name>A0ABY7EXI1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Period circadian-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022728">
        <property type="entry name" value="Period_circadian-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12114">
        <property type="entry name" value="Period_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Period circadian-like C-terminal" evidence="2">
        <location>
            <begin position="554"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR14050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="721" mass="81075" checksum="EC87A990111F01DC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZ60</accession>
    <name>A0ABY7EZ60_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PEG3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="896" mass="99989" checksum="6046977779A7F6D3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F097</accession>
    <name>A0ABY7F097_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FLP01-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="241" mass="27226" checksum="6426AA13AF0BDF2F" modified="2025-10-08" version="1">MASQYDKGFSVMFPGDSGETLDVSPNLSNEDEMQNVEKRDKSFLRIGRTPSEPTFLRFGRSPSQTFLRIGRAGPVKTFLRIGRSGFLRIGRGLDRKYIRLGRSILHAGEDEQGRELTPEQIQFLMENKERLLQLLQPSQNQQASSEFEDDGSYFAFPRQGRAMSFYFPRMGRSGDNNLEDSMLCCSGVRSILTTEKAIDICSPDQACCSGLNQKTKLYKNVVITECSEDSLDKIRAYIGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2P2</accession>
    <name>A0ABY7F2P2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">procollagen-lysine 5-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MAR_005447</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">MELC-2E11</strain>
            <tissue evidence="18">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl-[collagen] + 2-oxoglutarate + O2 = (5R)-5-hydroxy-L-lysyl-[collagen] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:16569"/>
            <dbReference type="Rhea" id="RHEA-COMP:12751"/>
            <dbReference type="Rhea" id="RHEA-COMP:12752"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:133442"/>
            <dbReference type="EC" id="1.14.11.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Lumenal side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Rough endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.14.11.4" evidence="5"/>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057589">
        <property type="entry name" value="GT_PLOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001006">
        <property type="entry name" value="Procol_lys_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF45">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25342">
        <property type="entry name" value="GT_PLOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01325">
        <property type="entry name" value="LYS_HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0847">Vitamin C</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046840888" description="procollagen-lysine 5-dioxygenase" evidence="16">
        <location>
            <begin position="22"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="17">
        <location>
            <begin position="622"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WAR15342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="718" mass="82525" checksum="B6A8FDBF5DCDF4F7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F455</accession>
    <name>A0ABY7F455_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="280" mass="32481" checksum="FDFC5E484379BE02" modified="2025-10-08" version="1" fragment="single">MLEKLAYVRLKIVDSPNPNILMEKIMCGVDRYDCAYGHCKECANRKMPTTNEYTEAVAATKVSYYQQNRDCRVERRPKECSKNHESRRDRKKPLKILKERYIKHVFNIKHQYRELKNMKDNLCESGCVILLDFSENYNGKLAEEIQTMHFGGNRRQISLHTVVVYVKDKTHATWNFTETGHGKSAADGVGGTVKRTADRIVANGKTINNATALFENDLDAESVEVKCMARIGHSRYFWPRIDDIIWYTWNHVMMPIPEPSHVRGRHCQIDPEKFKAIEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F490</accession>
    <name>A0ABY7F490_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">OXDD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_030793</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="134"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR16199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="295" mass="32007" checksum="8C97E1636D6F736B" modified="2025-10-08" version="1">MMSTSGSVAVLGAGVIGLSTAAAVLDLLPDVKVTVMADKFGADTTSYGSGGLFVPSLFSAGEDNKHRYRQWMRESGSYFRELLTGPEAGVAGAMALSGFLLARTEEDIETRLCDNDLHHKPEQIPAMDAEELCGQFGAVVNCTSLGSRELCGDRKLYALRGHMVRVRAPWIKHWVYVDHDTYIIPGEDLVALGGSKVEGDETLIPDPARGREIRDRCERLCPAIKCAEADHEWVGLRPCRKGGIRLEIQTLSTGGRSMKVIHNYGHGTSGVAYSWGTALEAARYVRDVITPGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4K0</accession>
    <name>A0ABY7F4K0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHST1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="314" mass="36258" checksum="DBD89649BD9C6293" modified="2025-10-08" version="1" fragment="single">MLIAYKRTGSTFLGDLLGRRADVFYWYEPLAEGRIKNYLKGRNLLCEYSKPSCRNISEADEKSAVNAISHLSDIFSCNVARPASWRPFVNCTKNLGNRHVQRCAHVLQDSCKHSQHRMVKILRIDVEIVGSMLESNPRLKMVLLFRDPRGSMNSRLTTTWYRKFVNTDSKKSDDAEVLCSRLTDDISAGKILKAKFPGRVILLQYEDFDGYEDKLHMLYDFLNIGPPKEGAVTVFKKGEHVNHKAAGFHPFNYRHEMSFRVNEIINVHCSDVYKELGLRQFDNENDYKNDNISSSQTLFSYEALYQTIYTLSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5L2</accession>
    <name>A0ABY7F5L2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_030926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF26">
        <property type="entry name" value="RE23625P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="2">
        <location>
            <begin position="76"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR16332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="164" mass="18697" checksum="42086A9F5DAF7463" modified="2025-10-08" version="1">MTTFESILDHTGCSCATATDMEEKKKNQIGVNESFDNSVSRFDRKLDRIRREMHDLDAEVPELQVAQPFVTDPEGNRKLSLRFNCDKFKPEEITVKTTGNVQNVHAKHEEDRTGKAVTWSSYETTRYRKTLKSTLYKDGLLQIEAPAPPAVEAPLENLIPTERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5N0</accession>
    <name>A0ABY7F5N0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S12A8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_031749</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12 MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="600"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="103"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR17155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="666" mass="73738" checksum="069B1DFE7A01B9B8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5X0</accession>
    <name>A0ABY7F5X0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NCOA3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_032144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd11439">
        <property type="entry name" value="bHLH-PAS_SRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056193">
        <property type="entry name" value="bHLH_NCOA1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017426">
        <property type="entry name" value="Nuclear_rcpt_coactivator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10684">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10684:SF4">
        <property type="entry name" value="TAIMAN, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23172">
        <property type="entry name" value="bHLH_NCOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="340"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="861"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="950"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="976"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1228"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1255"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1422"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1567"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1606"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="981"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1314"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1342"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1357"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1447"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1466"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1498"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1606"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1621"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR17550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1707" mass="185334" checksum="ECB1617679231371" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F741</accession>
    <name>A0ABY7F741_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GAL2B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_005206</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="23"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR15101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="352" mass="39473" checksum="82AF5D136B16865D" modified="2025-10-08" version="1">MEDPAVVTVMVMLSLFSICGTIGNSLVLHIYSHKKEKSTAGIFIMSLAGTDLFTCLFVMPFTEVVVYLNYMVSYDVACQIYMFLITCNVPFAAFIMVAIAIDRYFCICHPFLHVLNIFRAKVIVLCLLLVASTFGVITSLSYGVYTYKIIVPANDVLARTNETKSVKYGQNATFNTADHGECTNCSNELEMDEWDYRVFDNNKTEMQAGYKLSYTGLCAPNYILTSPQFLNFYQRAYAGTYLLSFAVVFILYGLIYRSIHKHRAKRSRRKRSGLYPSGVTSLLPPGVDLKNAEKQLTAVTRVNPHSGRRSDPRLENGDGDVDVGKPVELQPLRPTAKNITRSISIKEKTLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8Z1</accession>
    <name>A0ABY7F8Z1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposable element P transposase-like RNase H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="1">
        <location>
            <begin position="323"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="777" mass="88605" checksum="4CAA9D676AC019C0" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9R0</accession>
    <name>A0ABY7F9R0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">WDR35-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_032120</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056158">
        <property type="entry name" value="Beta-prop_IFT121_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056159">
        <property type="entry name" value="Beta-prop_IFT121_TULP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057979">
        <property type="entry name" value="TPR_IFT121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057361">
        <property type="entry name" value="TPR_WDR35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056170">
        <property type="entry name" value="Znf_IFT121-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF5">
        <property type="entry name" value="LD29485P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23390">
        <property type="entry name" value="Beta-prop_WDR35_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24797">
        <property type="entry name" value="Beta-prop_WDR35_TULP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25768">
        <property type="entry name" value="TPR_IFT121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25170">
        <property type="entry name" value="TPR_WDR35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23145">
        <property type="entry name" value="Zf_2nd_IFT121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT121/TULP4 N-terminal" evidence="12">
        <location>
            <begin position="43"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121 second beta-propeller" evidence="11">
        <location>
            <begin position="157"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="10">
        <location>
            <begin position="472"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121-like TPR repeats" evidence="13">
        <location>
            <begin position="780"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121-like zinc finger" evidence="9">
        <location>
            <begin position="886"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR17526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="911" mass="104264" checksum="C8A31F81ADD48E2F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FA41</accession>
    <name>A0ABY7FA41_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046722631" description="BPTI/Kunitz inhibitor domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR17558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="32988" checksum="9F9AD12B10FA1170" modified="2025-10-08" version="1">MHILLALVTLVAVFGSLHVNGKESDSEDSSDEEDSSGSSDKDTKRKCFADPNIRNKCQKRRPRELFFFNSTSSQCEESSQCLHGPNSFKTEAKCESQCMRLVGNGNVSEECTDYSTCSVTCGQCTLTRNCTPGPDNSSSCSGIETKTVELPPCGQETMAFADTMADVGCRRPLCEAEVVQANVGCRRPMSEADLVQADVGCRRPMCEAEAVQADVCCQRPTCEAEALQANVGRRRPVCEAEAMQTNVGCRRPMCEAEAVRADVGCRQPTCEADVLQADVGCRRPMCESEAVQADVGCKRPMQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAH7</accession>
    <name>A0ABY7FAH7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="131" mass="14333" checksum="82E39FF41358E8DD" modified="2025-10-08" version="1">MSRDKDLRPRCYDYGSRGNDKRPRETSGQYVTTLGREVPTRGPEVKTSGPDVTTLGQEVPTRGPEVATRGTEVKTSCSDVTTMGREVATRGPLVKTSGPDVEVQDIESCCRQEFMCGVFVAGESMSMSIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FB89</accession>
    <name>A0ABY7FB89_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_000267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR18429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="174" mass="20138" checksum="524D18305DA79CCF" modified="2025-10-08" version="1">MSLYSNKVYKDCVTAAMVELRGTGRPTEPVEPCSTDFQHAHYTFDFAQNLCLPHHSRQLGPMYFVTPSRDYDARWRWHSRARCCNFALSCTKRNKVISAVPIHLRVAWHHFLKKGEDTEETSYCVFRGGNVLRSRPQEVQAAGLSRERQAYLATHVRKYLRAKNKDTTCPLSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBI7</accession>
    <name>A0ABY7FBI7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTPRC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="185" mass="21441" checksum="B6685A705FF19041" modified="2025-10-08" version="1" fragment="single">MGKQLGDFGQFWGMVWEQEVEKIVMVTNLVEGEKAKCEQYWPDHYQSKLYGDIEVVCKVDKLYADFIWRQFKLSKNSEERSLHHLQFTSWPAKDVPDNETSLIDLRQRVNALPNTFDGPTFQVSVGAVVAVNPILMPRWILEYELRFKMCAHIDGNYCIECKTGFYDNECGSSCAPNCGECHRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBT0</accession>
    <name>A0ABY7FBT0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TTN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_001463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="556" mass="60322" checksum="4DF716C15FBA344A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCU5</accession>
    <name>A0ABY7FCU5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="363" mass="40741" checksum="B423D0BDFEEE2E18" modified="2025-10-08" version="1" fragment="single">MLEAQTTDNLENMQEAQTTDNLENMLEAQTTDNLENMLETQTTDNLENMLEAQTTDNLENMLEAQTTDNLENMQEAQTTDNLENAGAQTTYNLENMLEAQTTDNLENMLEAQTTDNLENMLEAQTTDNLENMGRPRLQTIWRTCGRPRLQTIWRTCWRPRLQTIWTKCWRQSGEHAGGSDYRQSGEHTGGPDYRQSGRNAGGQTTDNLENMLEAQTTDNLGNMLEAQTTDNLGNMLEAQTSNNLENMLKTQIMTEEQVHPSKIQDQISGNNALMKEMAVRLTSLKSIQTAAEELIKQATDLQDGDAKDDDEDDDSSVIIPVTQTNKRSWTAIGRVASSEDIGDNEPPRKQRTLPVLGPSTSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FD67</accession>
    <name>A0ABY7FD67_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_001926</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="8">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR20088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="308" mass="35622" checksum="2880506114694D51" modified="2025-10-08" version="1">MFKKKKKPQISGPSNFEHRVHTGFDHSQGQYVGLPSQWQGIVNPQEASRRRPMVDPSSITPIEIQPLKTIIRGNAQGQMNGSSVAISVARSNSLRNTSPPSRRRYQPDQNHPPLQEDGPMGHPGNNHPQYPGPPPYNRENRDPREMHPQDQFSKHDNRDPRNNNMHQDRNNQMRDNRYPNDRYDQRGDYPDNGRLQPPRDDYRGGSHPNSRDQSFEDRRSESSYRPHNDSYDSNTLRRDQHDMSPPRHNQMPPGGRSPNHPQMPGYHDNRICRIRATSMAIPRNSSSIVHLTDWPPSRYPQEANRPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDB1</accession>
    <name>A0ABY7FDB1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCNK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_000855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd20530">
        <property type="entry name" value="CYCLIN_CCNK_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20531">
        <property type="entry name" value="CYCLIN_CCNK_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="35"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="142"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="401"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="482"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR19017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="582" mass="64104" checksum="F942B2D52BB8419F" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FE14</accession>
    <name>A0ABY7FE14_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="40"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="438" mass="48840" checksum="889455B68B6DD419" modified="2025-10-08" version="1">MIRKLRYFFINILPGPTMKTVLIVAALFAGIDLVSGGAYDYLCDKTDYENSVTFYNHPTDCSKYVQCWQNSLGKLESLERQCGFTTYWSMSDMTCVRASLGYCQNDLCRNVNDGDHRMAEGNCRGYWQCERGISVPKCCPSGQHYNSSYGCEDNIDGECTDDCLGKYVAPVVSTNDTDSGNTTDTMQDLTTTEVPIICDKQEIAGKPSSYNWNVNSWSYQMDCPSGTVFVQKECSCLSSEKAALTCRPELLLTFTNGLMDASRNKLEVRNVSVMVENGEAVFDGVKSQLVIPFFTNLDIKDTLIVRMKYTSDHTEILEGETRALFSNFDCSVEPSIQMTENSQNLTALVGTWEQFSVSVDVPQKPLAANETVSEKNVVYKFHKNQLSLSVGSDSNSVETKPGQLRKIQCALHIGYASGMKNFKGRIDEFAVYQCDPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEQ4</accession>
    <name>A0ABY7FEQ4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B box-type" evidence="1">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="310" mass="35381" checksum="14E29148EA291505" modified="2025-10-08" version="1" fragment="single">MATGGSSIYKGSDLIHEYSCSKCVENDLNSEAKHFCPLCDHYLCNKCVKLHNGYHNKHTVYGHGDMQKWAGFYMDRCDQHGNKLEVHCDDHQELCCSVCVALTHRDLNSLGNVDSINSMTKRTYSDHVYETQGSTFHSVRIKKDIYKCYIVSICEFPSGEVVIADRRNSRVKLLNNLYQVTDYYDLPYYVQNLCLTAGDNMAVAVDDSLSSHITHEIHFLSVTRGKLQAVRKFTTNHNCRCIAHHQGQLYVSSNCALFQYTMDGTPVKKILEHISRGWPEHRCAVSTDGLRIYETYLSEKKLITLDKDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFX7</accession>
    <name>A0ABY7FFX7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CALM4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_001917</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR20079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="135" mass="15314" checksum="7D9361029358CD81" modified="2025-10-08" version="1">MSGRVPLMNSDITAVEAITDEERAELQDTFKLFDRDSDGYLTPRELGEAMRAMAQHPTELEIQELTKKPENSVDDGPQMTDFDAFLQIMAKRTGVISAADLRRIVTSMGERLTDEEVEEMIREGDDDEFTQHMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHJ8</accession>
    <name>A0ABY7FHJ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="269" mass="29631" checksum="6E9EA0136A36ED7E" modified="2025-10-08" version="1">MSAIHHAAMKGHADIVQTQIDAGSEIDAQENRGETALERARSDQMKDILKTAIDIHKEMNMVNTTTLLNTLKAVSKPASTYKPACHANLKSKSFLPADWKPVSNANVKNLINEKKSKLSAMTSQKYRTELARRAGTNVIEDQKITDKSGHGFVIEDKQQADEIVDKKGVDDVLIESGGTDVNNCLEKDHKVEGSEDERAGDNDGESDAQSNEASEDTTTRSDGKERTDDVMQNVEIYVNSKAPDSEMGTVENEETELAEKKNSHWSCHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHS5</accession>
    <name>A0ABY7FHS5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HEPHL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_002096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="2">
        <location>
            <begin position="42"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR20258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="437" mass="48976" checksum="46C6D4F0F4E94F96" modified="2025-10-08" version="1" fragment="single">TSRRLIENRDDQIGSVYRKVLYREYTDETFTQQVHVPDWMVYVGPFVKAEEADSVKILFKNMASKGNFSIHPHGFFYDKRGEGARYEDGTSGADKVDDAMRPAGSYLYIWNVTKRHAPTADDDACVPSGNHGHTNPTRDIASGLAGIGFICKKGTLDVDGKRKDVDKEFVVYVDIADENKSFFFEESIQKCRQPDACQARADAGDEDFGQSNEMHHINGYVYGNQPPFKLSPGDRAVFYVITEYALVNSASFLSAYTVACHPGHWLLYCRILDHRVCLLSWTFQINQYFRKSLVKVEATEGYLLYMSTVSEEIKWFLQTENKLQTVHELKLSNSTFTTSVTRGDKENHSGFTGPNIKGEVADTILFELNNKASREYSFLAGGVSMSKENEGAVYKQSVGATTSSGATVEPGATYMYEFFVSSINAPTKIDSSCLTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIM8</accession>
    <name>A0ABY7FIM8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="77" mass="8401" checksum="EF092EC811DA2EC4" modified="2025-10-08" version="1">MCIDVLSDAPGPEQHYMCIDVLSDAPGPEQHYMCINVLSDAPGPEQHYMCIIVLCDASGPEQHYMCMNVLCDAPGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FK62</accession>
    <name>A0ABY7FK62_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="306" mass="35672" checksum="07E0C69F4BD754DA" modified="2025-10-08" version="1">MTVLKRKAVYSVTEVSSANKVNKLSPLVRSGQRVAYLEIASNELAQLTKEFNSLRNDYHVTSAYYYYCYCYCYCYCYYYYYYYYYYYYYDDDDDDDDYDDDDDDDDDDDDDDVDEQNTNHAFLLSLVTLIVVVASLRVSEQVFQEEGWTDQRVSSNRASYRLFQVRLRTNMSNFIGLGLSREPVCDRDSPVTKDCFDDNRWTFKKASGQNMSWARNSPSACPTCGYLFRSQHTVLPAHETQRNRVFHNATQHRGFLAVIKLLVFVLSPNTGQHVTFSVTFFLFPAVFMIPDGDNLPKTSYPLPLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FM09</accession>
    <name>A0ABY7FM09_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="6">PARP</shortName>
            <ecNumber evidence="6">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_015745</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="6"/>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd01439">
        <property type="entry name" value="TCCD_inducible_PARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF67">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Macro" evidence="9">
        <location>
            <begin position="16"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="7">
        <location>
            <begin position="312"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="8">
        <location>
            <begin position="406"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR21771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="604" mass="67958" checksum="2EE8D21CAAF4B956" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FME2</accession>
    <name>A0ABY7FME2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_036971</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044975785" description="Transmembrane 9 superfamily member" evidence="9">
        <location>
            <begin position="24"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR23302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="490" mass="56529" checksum="DCDB75B42E4B4922" modified="2025-10-08" version="1">MATSMEMKFLVILCALAARVSYGFYIPGVAPNDFNKGDPVDVKGVKLTSIKTQLPMEFYRAPFCEPIKALQNEPCSLLCKEQPSKKLSVKESKILVDLIKNDYYVHLLVDNLPCATKFQMLDSKADQYEHGYRLGFEKDGKFYLNNHLSIDLMYHQDEVANTYRVVGFEVQPVSRAINGQEVMFTYEVTWHKSDLKWASRWDTYLTMTDVQIHWFSIVNSVVVVFFLSGILTMIMEETMEESGWKLVHGDVFRPPKSNKLLSSLLGAGIQTATLYPGFIFCICFVLNFFIWGKHSSGAVPFTTMLALLCMWFGISLPLVFLGYYFGFRKQAYQHPVRTNQIPRQVPEQAWYMNTFASILMAGILPFGAMFIELFFIFTAIWENQFYYLFGFLFLVFVILLISVSQISIVMVYFQLCGEDYHWWWRSFIVSGGSAVYIFAYSIFYFITKLEITAFVSTLLYFGYTLLMVTTFWLLTGTIGFYAAYCRSVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FN87</accession>
    <name>A0ABY7FN87_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="92" mass="10448" checksum="058A236131E8AE6F" modified="2025-10-08" version="1" fragment="single">KLFNLVTNIIIENGNASVFSPMIPAPGGCCPISESSAESRHETSTRRLKSPANPKRWPRKTFYCSSINREKARITIQVQRLEMCLPLPRHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FP80</accession>
    <name>A0ABY7FP80_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_037702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="36"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR24033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="169" mass="19185" checksum="0F87BE02BD11E23A" modified="2025-10-08" version="1">MAVVYVTQKKDFLLRRVQVTFDGERDRFWVSYLNRHYTVTEKAHHTEEILATYDLKSINGLVIVSGDGMYHEAANGLVRRVATDTGNDVNNPDYEPPEFPVTIGLIPCVTLIERIFFKSFRRMSLTLKFRAPPEYSESNDNAFRTGGRDTAENPEGESSAIKSNTMQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FR20</accession>
    <name>A0ABY7FR20_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_038276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="1">
        <location>
            <begin position="93"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="254" mass="29152" checksum="BF60F50A582C801B" modified="2025-10-08" version="1">METRRKYKKLQTLFFQRGEVLIPETVNGRVLEEPEKKVHLFGFRDDALPIQYNFLIDEAETMMQDGGGIHGPDAVISLVDYALTETMIGLNEEIRYLMQVAGHARCIIDAGFGRIKALYRRTDCETLSDLENVVASSSTTNEAVLYKKPDGTSRFKWREWKTFLGEQFRALKGIRSYQQFRFTSESPGIIFLKKGEDNEETSYCVFRGGNVLRSRPQEVQAAGLSRERQAYLATHVRKYLRAKNKDTTCPLSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRK7</accession>
    <name>A0ABY7FRK7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MAR_037190</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">MELC-2E11</strain>
            <tissue evidence="19">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd06705">
        <property type="entry name" value="PDZ_MAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05609">
        <property type="entry name" value="STKc_MAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.20">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037711">
        <property type="entry name" value="MAST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015022">
        <property type="entry name" value="MAST_pre-PK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023142">
        <property type="entry name" value="MAST_pre-PK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF414">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08926">
        <property type="entry name" value="DUF1908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140482">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="148"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="18">
        <location>
            <begin position="452"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="17">
        <location>
            <begin position="740"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="552"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="831"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="925"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="562"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="623"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="639"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="836"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="861"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="880"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="925"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="939"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="957"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="971"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1020"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WAR23521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1156" mass="129164" checksum="1DA867EBDAB9890C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRR2</accession>
    <name>A0ABY7FRR2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1833"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1833" mass="184433" checksum="490B7FB9B097511A" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FS81</accession>
    <name>A0ABY7FS81_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_038539</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046722641" description="Palmitoyl-protein thioesterase 1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR24870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="281" mass="31543" checksum="DAFB892142A7CEBC" modified="2025-10-08" version="1">MADNMKLLLISSFLCFVVYASNGPVPVVIWHGMGDSCCNPLSMGSIKKLIEKQVTGAYVRSLEIGSSIEEITMVCSKLAADPKLQDGYNAVGFSQGGQFLRAVAQRCPSPPMLNLISVGGQHQGVFGFPHCPGGNETLCEYVRKLLNIGAYISLVQAEYWHDPLNEQEYAEKSVFLADINQERSVNATYKSNLLKLKNLVLVKFLQDTMVIPKESEWFGYYNPGQDKKLYTMFESPLYIHDKLGLKTLNDTGRITFLSSDTDHLQFTEQWFIDNIVNKFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSW4</accession>
    <name>A0ABY7FSW4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="81" mass="8619" checksum="5668152A0233C99B" modified="2025-10-08" version="1">MSGLSLPPIRSGLPTVQSMPNLQNMMRPSSGSSDAGSTASTFLPPLYNDTCTFNAPRAVHTPRTFSKLPAIGRRAKCLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FT93</accession>
    <name>A0ABY7FT93_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_038178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF3">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="246" mass="27835" checksum="8A0C8F603FF54DF6" modified="2025-10-08" version="1" fragment="single">GATIPPSSDNLPNYDELSTGWSSDPALLPKLALSDIEKYLIHSSHRTSDSMKMECYRQYIRGLIFYKEKYVHKVMINTLSESSSHCYVKSKCHPSMKQGFHTQWVLMTKGTHLLIMKANCTCPAGSKLADRLGNKSNAVLFDLISPTENDVPVETDLKIADEVKVETSEFITYRSDKYIDLSKTINENQIFASDFLETLSVCGGDVVEEIEMRTRGQHKNPLLDKARKDKITASIFHDVLHRKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FW47</accession>
    <name>A0ABY7FW47_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="184" mass="20898" checksum="CABCD01A70DAABDA" modified="2025-10-08" version="1" fragment="single">YKSTSGIRGYESWPRDPARDTWRSFVNGRLVEIRKVVCKDRTVTTMTSTTHLPRITPASTPLPTGVTQPPPRSQSATAIYVPYPPKELTSAIDFIRIPKRVNPLAPPPPRRRINWTWETTDQHYENEKRSLLMQKREHTRYHSAWGKAFYGAPAEKEAYSENSGYSESCGYSVSGEYSENGGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1D6</accession>
    <name>A0ABY7G1D6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PAR12-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_013982</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057602">
        <property type="entry name" value="Zfn-CCCH_PARP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF4">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25261">
        <property type="entry name" value="zf-CCCH_PARP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR28278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="779" mass="89594" checksum="1251D02A83515548" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1H1</accession>
    <name>A0ABY7G1H1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GST7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_010900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="202" mass="22663" checksum="13887D1F8B683AD7" modified="2025-10-08" version="1">MPSYKLTYFNVRGRAELARYLFAAAGQDYDDNRIQRDTWPALKPNTKFGQLPLLEVDGKPLAQSYAIARFLARELGLSGKGSWEAALCDEVLELTGDLLKEIIKYRFETDETKKQELQKNLSDVVFPRFLGFFEKTLEENGAYLVGNGLTVADLAVLAILDTPLRSMPGLLDNTPKLKAHRGLIAALPKIKEYIGKRPDTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1N1</accession>
    <name>A0ABY7G1N1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35538:SF3">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35538">
        <property type="entry name" value="LIG_CHAN-GLU_BD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="537" mass="61730" checksum="1623E7F2636E123D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3V5</accession>
    <name>A0ABY7G3V5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DP13A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_011680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047181">
        <property type="entry name" value="DP13A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46415">
        <property type="entry name" value="ADAPTOR PROTEIN, PHOSPHOTYROSINE INTERACTION, PH DOMAIN AND LEUCINE ZIPPER-CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46415:SF2">
        <property type="entry name" value="BETA, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046487172" evidence="3">
        <location>
            <begin position="17"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="24"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="108"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR25976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="471" mass="51557" checksum="C4E8313A71EBA469" modified="2025-10-08" version="1">MATIYGTTWGLWKSFAWLKMGLMTRNLLSVFEKDALVLKKYSVGLHNCCQRVMSAQNELCAATQNLAQHLRNYELQKFSLEPENSVLTSTLEQFAAYLDNVSSLQQIATHDHEQAMNRFMKVSKKKDREVQELNEELYAMRKKYHQTALHYYSSLNAVQYKRKCFLLEPIVGYIHAQRAYFSMGYETAELQIETKKTVDMIDSIEQQNQHSYYAEPPINMPYIPPNISLVQKSGYLFQRSPATPAQQSAAPTPSTGPNSPFLAETPIQFDLCTPDDATPNVNKSLAGPPKRINPFDQSATDVIDSLDQAIDNAAFVESFLVRFLGSMEVKQDRDPPSLLLANISALEDKEDGEVEEALPTTRPSGTGHYMHLIGDDEQDMLDEMDQEMSKLDVSQDSPRTRAMFSESFVKRDFTKIIISPGIVGGVGGRGGGGGGRCVGGRGGGGGGCSVGGRGVGGGGGGVGGGEGGGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G696</accession>
    <name>A0ABY7G696_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3">5.1.99.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_003030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3"/>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="45"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR29462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="268" mass="30287" checksum="4B0A8E5BDC46341F" modified="2025-10-08" version="1" fragment="single">MDRINVSRLSFRRKGSHKKDKHRQEHFENSSEDIPRIKYISQTEAQSIDQQLFTEYAFSVDQLMELAGYSCAVAIAKCYPVEEMTKDNHAVLVCCGPGNNGGDGLVCSRHLKMFGYKPTIFYPKRPSKPLFEALYQQCEGMGMPVLSFFPSEAHLITDSYNFVVDALFGINFKAPVRPEFEPVMETLKKVESPICSIDVPSGWDIEKGNANGLQPEMLISLTAPKLCAHLFKGKHHYLGGRFVPRTLEQKYELNLPPYPGTDCVVELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6I9</accession>
    <name>A0ABY7G6I9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HARB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_003620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="164"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR30052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="324" mass="36502" checksum="EDC4B671D47CF75E" modified="2025-10-08" version="1">MADAVAVIFQQRRCRRRKVPIRRVFNARISSIVVRDLDFVSRYRLDRVLFQNLLETVGQTLEKTYRGGHTIPPDTQSVRNRTGNTVYIGSCWSPVPRKRCLFSEVADTHGVSRSSVCRIIHGFVDDVINNVDNIKFPVQRDDQMSVKRGFYRKCKFPNIVLFSVDGTLVPILAPTANEESFVCRKGFHAINCQAVASSDLRFIDIVAKWPGSSHDAGVFDNSVLKDYLEADLEAVLLGDSGYPLRRYLITPILHPSNENEERCLHRSGGVLPVFLACCKLHNLCIDNNMPLPDAIVCADDQGIQQNQEATRPGLTTRAQYIQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7Z4</accession>
    <name>A0ABY7G7Z4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C1QA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_003025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF116">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C1q" evidence="4">
        <location>
            <begin position="66"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR29457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="183" mass="19953" checksum="271A6F8ED8F3FF17" modified="2025-10-08" version="1" fragment="single">SQAEHAVLLDELDSIKTEVKVTNTTVYQLAESVDINSVLTLGLRDGLERTRTALNTTTQTVDLLQEKHTRPAFLAILSDDISATTAGKATVFDDVVTNIGSAYNGKTGTFTAPIEGLYLFSVKITGYYKSTASIGTTDQYQLKLNNNLYLRLFADVNAKTHNFDSSSVVTVMELGKGDRVHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8S5</accession>
    <name>A0ABY7G8S5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PRRX1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_033362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043378">
        <property type="entry name" value="PRRX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46385">
        <property type="entry name" value="PAIRED MESODERM HOMEOBOX PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46385:SF4">
        <property type="entry name" value="PAIRED MESODERM HOMEOBOX PROTEIN 2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OAR" evidence="4">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR30820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="179" mass="20764" checksum="79D4BC94125DF9D5" modified="2025-10-08" version="1">MSTTYIATNFKDTCGAEDDKDDKDSKRRRKQRRNRTTFNSTQLAALERVFERTHYPDAFVWFQNRRAKFRRNERNMLTQRGPMGNPMYPRPQDSISMPIEQPVTPRGPPMNTDYMGWPSPAGYNNLNVNTSSCAVMNHSYSPPPTMGSIASLRLKAQEYNVMQSNPYGQMTQRLDPYEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G922</accession>
    <name>A0ABY7G922_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oligosaccharyltransferase complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSTC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042416">
        <property type="entry name" value="OSTC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13160">
        <property type="entry name" value="OLIGOSACCHARYLTRANSFERASE COMPLEX SUBUNIT OSTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13160:SF4">
        <property type="entry name" value="OLIGOSACCHARYLTRANSFERASE COMPLEX SUBUNIT OSTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="128" mass="14367" checksum="3E995593114C6D79" modified="2025-10-08" version="1" fragment="single">MESLFNVPFQFLECPNLKLKKPTWVRQPSAMTMFALVLLSYFLVTGGIIYDVIVEPPSIGSTTDERGNSRPGLASSFLFTLGGLGFVILDQTNVPIMPKLNRVLMFCVGFASILLSFFMCRVFMRMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G941</accession>
    <name>A0ABY7G941_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="85" mass="9640" checksum="3E53C3302B0F62B0" modified="2025-10-08" version="1">MINADIFIKLQRFTPELIYSWNNTTSVDIFLIWNAICEVSITKIKLSNAILCLSVFRATKPPATGSESLQQRPLNSIESWKIPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9H6</accession>
    <name>A0ABY7G9H6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COCA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF84">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="504" mass="54416" checksum="008811499114C239" modified="2025-10-08" version="1">MSPYMRDGVLGGVGAGDAAISQDLFKQLDFVSRFAQTFDIGPRNVEIGIVTFAATPHNEFNLNTYSTKHDLVAAIHKVGYHTGGTRTDLALKYVEANSFTQAAGDRAGVANILIVMTDGKSNVPAETVKESAHIHSNLNAKTIATNSQHVFNVSSFDALNTLHAELKKTACRTLCHYKGLYYRQGESWYDGCGLQCRCEDALNHYYQCTDRCPKYTNVPSTCTFVADPKDPQCCRVPQCQNAGGNDPRDACCQVLKCDAAQTFGTCQDKVNCQSYGNYVCGQQYEGWARENCGKFCGYYGGGTNPYLATAPPSGACVDAIPNCAQYDVSVCTDAQYRPWAVANCPKHCNMCGATGSGGVITGSGTAAPGTGTGTGTGTGTGTGSGYVEYSGGCVYKGRYYGAGDHWYDGCDYNCTCENGQTGFYRCGDRLSHRERLSQTWRDGCDYKCECTDASMGRYRRTALCVVWNLPPTCHWDAPAPGKCCQTPNCPSDVVLSYPPGYTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9M3</accession>
    <name>A0ABY7G9M3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRI45-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="92"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR30042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="580" mass="64825" checksum="294051A12FD1526A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GA13</accession>
    <name>A0ABY7GA13_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_033794</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="34"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="65"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="126"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR31252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="491" mass="54942" checksum="822F92C2355CAA96" modified="2025-10-08" version="1" fragment="single">TPEDMTSGSSEAEKQAELRRKIEYKVACEERAHKIVQLITPSHYEDITVERAIAKLCGYPLCQNNLEKKSNKTGDEAGKDETKADSQRGSVNTEKARGNISTDEPCVYTLDKAMSDLGMTDGGEGALHEKDDTIAESDKDSQDNFRTEAKEADSEEDFQRTDKHSQNERPSETCTKVDQSSNVKVPNVEKETKLDNKQPEPSVSKPNKKDKKAATKAKTDYLMQLLDKRKSLLSKMVDIQDTSEDVVKPGEEMKENAELSDKKLEYLGDTVEPKVMERSTASQGVHVREIQTVHVKHGAQSTDSKKSNGVCPKKQVSTLKLICETLRSWISQDTVEFLNTGQAETGSGDSRSDSASMGKKSDMERQYDALVAKVDAQEAEFDNLLGEESLEEVAPPSGPLPHYEVLKEEIEENQYRVQKLTSENIIFKPAEWTLVALIMLKLLSKKIPSLEQAFRSPSSEKYFNLLLSSLREDMTTLQSHVDSVIPTLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBR2</accession>
    <name>A0ABY7GBR2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="8">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_034385</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of the anamorsin/DRE2 homolog, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03178">
        <property type="entry name" value="NDOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028879">
        <property type="entry name" value="NDOR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 8" id="KW-0288">FMN</keyword>
    <keyword evidence="6 8" id="KW-0521">NADP</keyword>
    <keyword evidence="7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="9">
        <location>
            <begin position="8"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="210"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="61"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="369"/>
            <end position="372"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="403"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="481"/>
            <end position="482"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR31843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="556" mass="62607" checksum="86131DE67CF52C11" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GHD8</accession>
    <name>A0ABY7GHD8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_033108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="81" mass="9415" checksum="A410F6EDD73DB772" modified="2025-10-08" version="1">MGGKELKIEVPIIIGSNPKGLEIPADYEKDVNIHWTRGRQDVTQDSMKEQQELKDKWIVESPEFRKTDTQVMNPLFVVYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAD1</accession>
    <name>A0ABY7DAD1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="266" mass="30958" checksum="5692AB165873B954" modified="2025-10-08" version="1" fragment="single">SKPLLVAAIDFGTMYSSWAFSFRHEYESDPTQISAKQWLKHESTKGPTTVLIKPDGRTLEAFVFEAETRYAELIDEEAHESYYFFKRFKMKLWNQARFDAMADLKRNHLYDFIDLFRRFENKKRSISPDKDSKMIIPLPLSLCTLIEKRQGRALCDLIKNTYYASSHIEIGQKLKVGETQFKRRYVSMESDQSSIVFPIFITYEKNPMYTTDPGCTCVGNLTIPLSRSGKDREVIVRFIFGGTEIDVEATEKSTRKVHHLKIDFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DC59</accession>
    <name>A0ABY7DC59_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HIP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_006426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF113">
        <property type="entry name" value="COMPLEMENT C1Q-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047194685" evidence="4">
        <location>
            <begin position="21"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="75"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ93955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="215" mass="24154" checksum="4B73EA7E84C0C1CC" modified="2025-10-08" version="1">MASNLIFLSVLLLSLEGGFGSECAAMSECCGQGHNYVELFKLYLKSVNGYDEPLFDRVTALERLMTELQSDLDALRPANVLFKAKTLNDRSLATDQILVFNDVMYNYGNGYDSKTGKFTCPRNGTYLFTTSICINGGEALYFVFDIMVDHQTVTRSTFAEHVSMGSNCHTGEAIVNLVENQEVYLKYTYTSWSTDGIREEALYRWNTFSGTILHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCZ7</accession>
    <name>A0ABY7DCZ7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RFA3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_007264</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ94793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="119" mass="13258" checksum="20CE1891B42C7AB4" modified="2025-10-08" version="1">MAKHGKSKIKMDEHQTTRVNAAMLPSYQGKNVCLMGMAKDVDTNGTSFTLTTSDGKDVRIQMQEPVHGQVDGRNSIQCQNYISFSDETSQSFSLDLYNSAVELMVRAPQHYQQGIQPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DEA3</accession>
    <name>A0ABY7DEA3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TENR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ95258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="84" mass="9451" checksum="0EEF2E426678B790" modified="2025-10-08" version="1">MMLGNESRYIEYGSFSMEDETGLYKLHVSEFTGTAGDATYDRDSDVYRGNCAQQYHGAWWYDGCHSSNLNGDYGNTTFGPLVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DG33</accession>
    <name>A0ABY7DG33_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TM104-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_028094</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TMEM104 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="17"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="114"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ95404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="368" mass="41080" checksum="192C0B0B37191BF8" modified="2025-10-08" version="1">MVNPGISETGEQYSKTVGLIFIFNLIVGTGALTMPRAFAAAGWLLSLITIIVLSFMSYMTVTFVTEAMSIANAINKKKDGEDHNGALSPFEITERTELKTKYLQLVTSLSRWIAFGMMIVLAVIRIGKKKGQGHPSVADISGVPNLFGVCVYSFMCHHSLPSLITPIKNKSRLYALLASDYFLILIFYLLVSLTGIFAFNSIEDIYTLNFFKPDSCDESNSITNVKFIEYFLALFPVFTLSTNFPIISITLRNNLKALGYKENRPYPFWLDRICFPLLALVPPMGIALATNEVEFLVGITGSYAGAAIQYVIPTLLVFYARKQVSECSPQSQIHASPFKSFRWIVFVCIWAALCIIFVTVNHIITRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGW3</accession>
    <name>A0ABY7DGW3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetylneuraminate lyase</fullName>
            <ecNumber evidence="5">4.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_029203</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23296"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17122"/>
            <dbReference type="ChEBI" id="CHEBI:173083"/>
            <dbReference type="EC" id="4.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-sugar metabolism; N-acetylneuraminate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DapA family. NanA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.3" evidence="5"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF21">
        <property type="entry name" value="N-ACETYLNEURAMINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAQ96513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="280" mass="30902" checksum="17A0378F4ACE7DC3" modified="2025-10-08" version="1">MADFRLHDQIAAPFTPLKEDGEINFDLLDKYADYMVNTHFKGIFVNGSLAEGMSMTIEERKQLADAWMKAAKGRLQVVVHVGANCIKDSQELARHAEQIGVAAIAAFSPSYYKPENIDVLVDVMAAVAGAAPKTPFYYYDINFCTGVYIDQREFMQAAKGRIPTLRGLKNSSRELPASHNCTFVEGCQVLIGSDNQYLSALALGIPGVVVASYLGNLFRDMRTAYQAGQVEKAREFQIFSGLDAGSVRLPLRQLSVAEYEAMEKDFRAAGLVEIALPREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJ08</accession>
    <name>A0ABY7DJ08_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TMM26-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168">
        <property type="entry name" value="TMEM26 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="498" mass="57338" checksum="749C40CEF4590A9A" modified="2025-10-08" version="1">MWRVRYDHQNGYDGLFSTYELPYGDFDDEWRRSRSESTPASSRPAREEVPWAFGSVYDPGSELEAADVKSDEDPVSYLAWIKQPNLNDDKASIPSVEFKMKDREDSDSVLFTDKSLEPNHMKLNLSNGSLPIKQLEKYHKISDNDDDDEGQEVPKDPNVLLYGNHRPIFWAVFVRVLLVGHNVLTVWRVTEALGSPLYWLLAVLNLFLLLELHVVVVKRAGIEYSWWTPCFLFYLGSTIPSIWLLQLQLYDEFTSSGPGADVTSVSTSAPSTQFTGFTTQAPTKLAMNNEVWLIIVQEALVYLLVFSRWLLPRGAVSRAFLADLLLEFLAIASDIMELLAVFDEEEIRGNLSLTLAILTVWSASFIQFIPVLVHKRRFRHVRNPKVPCINRYFGDKFVEIVVTLMNIFLQDLPFLVVRLYIVFEIRIITYSLIFFILKNIVSLMLLFYRLTIMGKRLPIVRQCCQRLHCPCSPPSDHHHNTPSFHLPRIDKERSAMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKC7</accession>
    <name>A0ABY7DKC7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MEGF6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_022545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046054813" evidence="5">
        <location>
            <begin position="20"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="426"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="490"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="527"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="616"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="661"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="707"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="746"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="7">
        <location>
            <begin position="791"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="948"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="994"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1040"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1222"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ98172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1258" mass="133721" checksum="0CAF6EBC64476931" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKX2</accession>
    <name>A0ABY7DKX2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="4">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_022740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF32">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="113"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ98367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="702" mass="77363" checksum="DCB16BFAD7C4607D" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DL74</accession>
    <name>A0ABY7DL74_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBFD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_030147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd17047">
        <property type="entry name" value="Ubl_UBFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039120">
        <property type="entry name" value="UBFD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057455">
        <property type="entry name" value="UBFD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16470">
        <property type="entry name" value="UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16470:SF0">
        <property type="entry name" value="UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25343">
        <property type="entry name" value="PH_UBFD1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="124"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="377" mass="41929" checksum="3C14C64EA2DC4584" modified="2025-10-08" version="1">MVLVRVEVVFVQVEVVFVREEVVFVRVEVVFVREDVVFGSGVCTCGSENNEDIKQDGDEATVGAESMATDSSNNAAKDEATSLQVDIHKTDVEVNSETDKPVADSGGGAADSTQAQTENCDKGETVTFKVIYNKQKYDITFELDKTILDLKKHVQTLTGVPSAMQKLMFKGLAKDENTLRELKVTKTAKIMVVGSTMNDVLQVTNTPSQKELQEEEKAATSKEPLCQQKQHKKVLDKYGKPDDALPGIRKKKEALPAYPLTGMYNKAGGKVRLTFKMELDQVWLGTKERTEKLPMNSIKAVVSEPLVGHEEYHMLALQLGPTEASRYWIYWVPAQYVDAIKDTVLGKWQLKDNYSVTSTCYVRVAKLREASLADMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNI5</accession>
    <name>A0ABY7DNI5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_023046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047391088" evidence="2">
        <location>
            <begin position="19"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ98673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="133" mass="15425" checksum="D47EAF2358169B5E" modified="2025-10-08" version="1">MDHFQSAFILLIFQSLAGKTWFCFASQTCKTNDIKTAVLLNRETQTDLKEHKMEMDQRLNEAAELRMKMIENEQELAWLKDQQANSSAVTTSGGPPVYFLVHSPLSLTYKSGEIVRYGTILYSHGYWRRREDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPI9</accession>
    <name>A0ABY7DPI9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EPHX4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="182" mass="20811" checksum="A300C0397CA37906" modified="2025-10-08" version="1">MSVSFFIQSVVAKIIGLFFACLISFSIFVQFVKGPIKFIKLNVLKLKKRNVMPPCLNDPSLGNHDFVHLEDIRLHYVASGDEGKPLMLFLHGFPEFWYSWRFQIREFRKDYSIQKIKRALATILVTKNVSWLPMTGAGLWRGISRQTTQSWWRNSSFATVPTLPSSLSTCAQTSHSLKSHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPY1</accession>
    <name>A0ABY7DPY1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="104" mass="11632" checksum="3892BC3D6FD4A0F9" modified="2025-10-08" version="1" fragment="single">MNKKDYKDVVAGTGFLELELRSVQTHNEVNDGNSAMVLTATVFTLIGKFAITGSFSTIFMYTPELYPTNMRKNLFHIPEMQEWDVISSGDSGGRGMLAPFSRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DR05</accession>
    <name>A0ABY7DR05_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="395" mass="45131" checksum="859C23B4C0A3ED12" modified="2025-10-08" version="1">MAKSKAERMREYQARKKEKLGEKEWLKKERARTKAYFKPMALLDESKQLETRENNRLNQIQFRRRKQEQKNTDVDRSNTESQPSTSTESNENEISSTTDTTITIKLPFPSRAQKGKKRTSRALSKAYRQRYDTSTSWLYFECGHGKGPCDGVGGTTKRNADNAVKQGKVLIQDAEDFLTWASKEEGGIKYQLITEQEYNHSKTEDDDRNAQIKPVKGSMKLHAMIGQGDGPLLTRNTSCACDDCFVDKFNSQSKCNWSEIAVTKRIPQVVEASPNQEDDEPEIDQTDDETTRNQSEPEPLAPTEVSEGCFVVARYDDMKYIGQVIEVCFHDNTVYINFMADSGKRKGCFKWPITEDKVWRDMADIIKVIQTPVPTTKAGRLFSVPENILKLVCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DR29</accession>
    <name>A0ABY7DR29_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondria-eating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32540" checksum="73346C4FFCDD7960" modified="2025-10-08" version="1" fragment="single">MSFLSETIDLSSLTTESDKEFDEDYIGGIADENWTKTQLKVIDRHKSKGALAEAHLGPVSERSVDKFKRNIGKLKALKNYAPVFGNFMQKYAAVNIGSETIAKAWMRVTETEGKNDDHMSSITGQSRSFQLAERVDRIFQREWQQFFAAARQKLPSQISNREIVICLRDILKFCYKFCIDISKIQREAIQYIVLLVPAPGGAGTDSREVTPVRINQGMELTVKELLVSATSKIFPVVFQTQQPAIALDFSGKTPRHFTNYTEESEDLDFVIWPAVLLSEDGLMISKGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRF2</accession>
    <name>A0ABY7DRF2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_024640</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="8"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="70"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR00268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="342" mass="37882" checksum="CF3DD2D4110B986A" modified="2025-10-08" version="1">MPMSKNKFNLRLPTHAGDEGADGAEKQNEVLLESLTQKLKELDIDDQQRERLEAFLTQKQKVGELVAEEFDKIGELGAGNGGVVMKVLHRPTSLVMARKVLHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPEPILGKVTASVLKGLIYLREKHSIMHRDVKPSNILINSRGEIKICDFGVSGQLIDSLANSFVGTRSYMSPERLQGTNYSVQSDIWSVGLSLVEMAIGRYPIPPPDPKDLDIMFAEDVMEEHKEAARTGKPLKSAGPTRVVSFPNPHGSDGPRPMAIFELLDFIVNESHPFVKCAESEEIDIGHWLCQVMDLKPENKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DS63</accession>
    <name>A0ABY7DS63_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="393" mass="46167" checksum="96E46E9FE2A38441" modified="2025-10-08" version="1">MKETLILEPLESEIPKNMLNEYHTNLQQVDSILKFLANNEDMSFNEFLVKCGISYENYILAIRSGLKKTQVFLKRRVVDMRVNAYNMGILKIWQANTDLQFVLDPWAVCVYISSYMIKSQRGMSKLLRHACEEAKAGNHTIRERMRIISNKLLNHCEVSAQEAVYLLLQMPLVQSSRYVVLINTSPHDQRKYAERPKLLEHISLAEFAEFFQEHIKRKALVNEDEADFDQTYLTIENIEPDIKIWLTNGGYLVKKIKPKVIRYVHFSHEKDPEMFYREKLMLFTPWRDEEVLKGQNGSYEHEFRKKEKQLLEAVDEIAPSSRQAEEEADSEKCDAIEHNMVQPNRPLHTRYDIGADIGLAINTHEEIIINNRLSNEEYNHLAQNLNNEQQQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DS94</accession>
    <name>A0ABY7DS94_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="19">GRIA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MAR_024642</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">MELC-2E11</strain>
            <tissue evidence="19">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd06380">
        <property type="entry name" value="PBP1_iGluR_AMPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="541"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="765"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="17">
        <location>
            <begin position="364"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="18">
        <location>
            <begin position="374"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="811"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="826"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WAR00270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="869" mass="97972" checksum="42B497AB861B39D3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSB6</accession>
    <name>A0ABY7DSB6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="152" mass="17539" checksum="E26A1F4E4274CD36" modified="2025-10-08" version="1">MEIVMCIDVGKCGCGYKPYFEQDAPSCLLLKQDKTIQAFGYEAERRYLALLDNKQHDQFYYFRRFKADLKTKQFRKDTVIEEEGGKSINGIALFKEVFKYLRGHFMDTLDESARYGNMDAVGGLTPCVLYSETEAAARYCRLIPLRLIKTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DT15</accession>
    <name>A0ABY7DT15_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">E41LA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_025240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13186">
        <property type="entry name" value="FERM_C_NBL4_NBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF4">
        <property type="entry name" value="BAND 4.1-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="6"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="867"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="916"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR00868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1177" mass="131971" checksum="D651A697837DC7CF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DT40</accession>
    <name>A0ABY7DT40_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GEN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_024213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF70">
        <property type="entry name" value="FLAP ENDONUCLEASE GEN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="4">
        <location>
            <begin position="116"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="521"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ99840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="601" mass="67470" checksum="5914DB7E5CE06D8E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVN9</accession>
    <name>A0ABY7DVN9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="99" mass="11783" checksum="E2F82A1FC4346D72" modified="2025-10-08" version="1">MNDAVRDTDKVYDVVRDTNKVYDAVRDTNKVFDACERHQFGVLCCERHQYGARCCERHQLDVQRCERHQLGARCCERHQLCVRCCERHQLGARCCERHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVX6</accession>
    <name>A0ABY7DVX6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MATN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_024838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046683296" evidence="1">
        <location>
            <begin position="25"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="43"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="246"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR00466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="628" mass="69620" checksum="F596828C5216A659" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYC9</accession>
    <name>A0ABY7DYC9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GCNT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_008218</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297:SF191">
        <property type="entry name" value="PROTEIN XYLOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR01660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="436" mass="51020" checksum="2BF3E33423BB5467" modified="2025-10-08" version="1">MNAASLDRNEIFAIKMFDKLTFSFPCRKYRLIVVLTLLMFVAAYLYVWYMREFHITNHLHTMALNEFDCTKLLSSDSKEMEKAIDYLEGKNKQFAHLPSIQYDTMEKLAGRETPKAKGVQLPYGTEEDTDFPVAFYIPFHENVVQLQRLLYIIHRPQNIYCVHVDDKLSSKDFEAVYRIANCYKNVFLTSRREIMVYGSVTEIRAELNCMEDLDNSGHRWKYLIHFTAKSFPLMTNSELVEALKSHKGKNIVHSNWPEEHIQFKRRHILVVEQITKSGYIRHTQDLKSKPPFGIMPTSGFSTNVFTREFVDWVLVDTKAKEVLNWMSDIMYPAQYYWATLNNLYHNGILQTPGGDCDAPGLKQLNFYLIGWNVPADRKLCRSGHYVRNTCVFSVQDLATLTQRRELVANKFDISYDPIVYMCMEQWITNKTRGNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZ43</accession>
    <name>A0ABY7DZ43_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mab-21-like HhH/H2TH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF69">
        <property type="entry name" value="MAB-21-LIKE HHH_H2TH-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="1">
        <location>
            <begin position="211"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="447" mass="52005" checksum="DD6490ACCC6812A7" modified="2025-10-08" version="1" fragment="single">MASNSGSRDGQQLSRNVFQVMNQLGYSPDMVNKRRQMQKDMDIAYNKNGDRYTRITAGSKAEGITCPYESDHDRLYEDKHVACVVAPEENSEITEKSMQKGWKSHAKAGPSVPRSKGIYMEDQVFSFRCLSQRAILKDWRERDRTNWPSRSLREEVIKCLPHLVPTGCKGSENFDKEWRICFIRGELALTCSLIEGQYKLYVLLKLVKKSCFAPICDSVSSFIMKNIVFWLSEEYTADFFTAENLLETATIALTRLHKAIVDNHLPYYMIPGRNLLHNRIKHADKAQLLETITELIQDGPKLVMRCKRISDALSTPEARLLQEGIKRDKLEILKLRMIKYRTEVCKPGMSHIEEMKLAWAREEYRQTQFKLMDILIPEWRCRLFSELSSSEVKLEDFSEEEIGLIQWMKSVLREVFLTVDYPYIMEEIKLNDPNCSVQMFDEDTVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0V1</accession>
    <name>A0ABY7E0V1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CLPX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_025163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase AAA-type core" evidence="2">
        <location>
            <begin position="123"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR00791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="298" mass="33256" checksum="4AEF1C2BAE684137" modified="2025-10-08" version="1" fragment="single">IVFLDTCCICVLQVLCSLTHVVFVCCRYCVSGHMLSLYVAGIVFLDTCCLCMLQVVCFWTHVVFVCCRYCVPGHMLSLYVAGIVILDTCFICMLQVLCFWTHVVFVCCRYCVSGHMLSLYVAGIVFLDEVDKLAKVKQNHNKDVGGEEVQQGLLKIIEGTKLQISDKRGKQGGESVSVDTTNILFVASGAFTGLERLVQKRLSKNTLGFGHQVEDLVTDVTPSLDLSSGSELDHLQVDECFRLAEDQDLISFGMIPEFVGRLPCVCPFHHLTEDMLIQVLTQPKDALIKQYQKLFSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E126</accession>
    <name>A0ABY7E126_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YK66-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="624" mass="70244" checksum="D90446CBBA2A412D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E161</accession>
    <name>A0ABY7E161_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase C45 hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047794">
        <property type="entry name" value="C45_proenzyme-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047801">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040521">
        <property type="entry name" value="C45_proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180:SF1">
        <property type="entry name" value="BETA-ALANYL-DOPAMINE_CARCININE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180">
        <property type="entry name" value="PEPTIDASE C45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C45 hydrolase" evidence="1">
        <location>
            <begin position="156"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="411" mass="46585" checksum="06766C234B144053" modified="2025-10-08" version="1">MQYMIRRANYFYRGQVKRNLRYLSLSENRTMSSVQSLPVLYIKASNQFDVGQAVGKTFKGFINDYMSDSKEVKMYRKFFNDPRGKPIVEQYLETSEKYHPDIMSEIRGIADGSGESFVDIFMLQLASEISMCHYDVLFPSEADSHSTPKGCTDVLVNRQSCRVIGHNEDWAFEVSSRVGIVHVTITGHEETKPMEQFLSYVFPGYLSGLTFGMNKHLVLTLNSLAPTQANVRGVPLQIVVRNLLTCDSISACVEMMASRPVGCGFGMNINIAEINTDKMCSVEVYSDKNGSSTDVHWAHDWVDGFYHHQNHYRRPREDMQAPVVAGSRIRYERVEEMTKEVPVAGVDDVRTILGDDKSERTPIYLTHSEKHSYKDGSTSATAIFDISNRVLHVYRANPRHSLPLASLPFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E175</accession>
    <name>A0ABY7E175_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR03763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="377" mass="44800" checksum="048E03E998C7E72F" modified="2025-10-08" version="1">MDDLHGPRPPYLVHMFEVTNISLSTLEYMFEVTNISLSTLEYMFEITNISLSTREYMFEVTNIPLSTREYMFEVTNIPLSTLDYMFEVTNIPQSTREYMFEVTNIPQSTREYMFEITNIPLSTREYMFEVTNISLSTREYMFEVTNIPLSTREYMFEVTNIPQSTREYMFEITNIPLSTLSNNIPLSTREYMFEVTNIPLSTREYMFEITNIPLSTREYMFEITNIPLSTRDYMFEVTNIPLSIREYMFEVTNIPLSTREYMFEISNILLSTRDYMFEVINIPLSIREYMFEVTNIPLSTLSNMFEITNIPLSTREYMFEVTNIPLSTREYMFEITNIPLSTLSNMFDLTNIPLSTREYMFEITNIPLSTREIICLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2B3</accession>
    <name>A0ABY7E2B3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MRC2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_019552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01504">
        <property type="entry name" value="PNCREATITSAP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1313"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="112"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="260"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="411"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="530"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="656"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="806"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="1022"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="1140"/>
            <end position="1249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR04183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1372" mass="151747" checksum="06D8D635B46E0FC0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4H5</accession>
    <name>A0ABY7E4H5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VL96-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_020277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd22758">
        <property type="entry name" value="OTU_232R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="818"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR04908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1010" mass="114085" checksum="EBC19CC52C997CC6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6S9</accession>
    <name>A0ABY7E6S9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_020010</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="303"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="624"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR04641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="775" mass="88346" checksum="C0658F67999DFD73" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6U1</accession>
    <name>A0ABY7E6U1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HARB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_021132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR05763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="130" mass="14918" checksum="4757DBD6B624BD67" modified="2025-10-08" version="1">MKDSAIQFPTTDRHRHRTKTGFHAIRGFPSVISAVDGTHVRIQTPSDDEEQCVNRKHFHSINVQASCDHRGLEDGILLGDSAYPCKPYMLTPYLHPDPDEATEIDKEHLTRMETTFMIINFHQTKPCMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7D5</accession>
    <name>A0ABY7E7D5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAIM1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010695">
        <property type="entry name" value="FAIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038513">
        <property type="entry name" value="FAIM1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13088:SF3">
        <property type="entry name" value="FAS APOPTOTIC INHIBITORY MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13088">
        <property type="entry name" value="FAS APOPTOTIC INHIBITORY MOLECULE FAIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06905">
        <property type="entry name" value="FAIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="136" mass="15188" checksum="841B29AB9F6E8A2F" modified="2025-10-08" version="1" fragment="single">SRMSSDHVATWTLSLPDGKHKVEFEHGTTSGKRVGSAKCTVSIDACSGFAYEYTLEVNGKPLEKFRDNQNKIQKCWCFTMGSQNSTPFRVVLEKDTLNVWVNGKVVETTAVSSGKRRDGIIHKLFVDDQEIPPAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8J3</accession>
    <name>A0ABY7E8J3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="147" mass="16878" checksum="6C17B4B0B457D9B7" modified="2025-10-08" version="1">MTEKLAALSKTNPNENMNMMISRKAPQGSTNERRARLYIKVKIIVIYNDDDDDDDDDDDDDDDDDDDDDDDDDEDDDEDEDDDDDDDDDDDDDDDDDDDDDDGDDDDDDDDDDDDDDDDDDDDLLSGERCPRSISRTYHNETLPGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8T8</accession>
    <name>A0ABY7E8T8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_021809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="291"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR06440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="408" mass="46190" checksum="DC1DBC6AF9B3BFC1" modified="2025-10-08" version="1">MTPRTVICDKHFLPSDINISLVTRKWTLKTNVEPSVFLWTTSTPVRKPPKERIPLTVSPVKGTQNQQAVHNISQSFESMLDIGFQDLTSGPTTRDIGCQTEDVMPTETTTCIRIPADHEYCSKAKLASSKVERLETALCEQKAEMEKMSQKIQELNEILTDYELNRFGLDKICDDESAMLFYTGFPSTESFNAFYNFLETKCKGLKYWRGQSGHEEAHTSGTNKVGRKRAIPIRKSFSWSLYTFPSVLEFQRVTSVKYLQLGSTFCRMNFLHYSQNMPLEFSQYPTTRIIIDCTEIFIEVSSTMSTQSQTWSSYKHNNTWKFIVGISPNGTLTYISGLSGGRVSDKEITKKCGLLDLMESGDNIMADRDGVMPLSLAHSAENIVKVIGYLTNFLPPLLPPGHSRKLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9S6</accession>
    <name>A0ABY7E9S6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">COQ3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_016756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR06798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="213" mass="24260" checksum="40B66544F6D7CEB2" modified="2025-10-08" version="1">MALQGLSRIEFPPMNGVFFARLHRTSGWCQHLESRPKRHYGTNRPVVTHTMDEEELKLFRSLANSWWNETGDFEALHAMNKLRVPFIRDGLVQTREEPSPSISQPLQGLSIVDVGSGGGLLSEPGGSLFVTTMNKTLLSKGLAIYGAERVFRVVPEGTHDWEKFVPPEDLRALLEKNGMHTRLIHGMLYMPVLREWRWVQDTNINYALHAVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9T8</accession>
    <name>A0ABY7E9T8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DIRC2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_016760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF27">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR06802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="326" mass="36137" checksum="6D36D49137D9EE2F" modified="2025-10-08" version="1">MHVDRVEGAGEQRPLLNRTAIYPVRWYIIATFSYGGLTQAVLYNTWGPVTESSKAVFGWTDGTIAMFPNAANIAFIITVIPVSILADIKGCRSCVRWGRDLEEPSCWPGLPRSPPCGFRPISGPPQPLLSQCQHIRWPGCVTIFIGTGIFPFSPTPPTKPLSRHRENPVGIRTQSPRQERAILGCIGGVCCACRHSWRLAFRIGRKSESSWYFTTSMYVSSVLIGVFINGAVPLCFEITCETSYPVAEGVSGGAFTLLTNLVGVGFFCILLIKNISYSWMNWVLFGSSVLAVILLFFFPERYCRIDIDIEPLEDAIRVSTVVPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDV6</accession>
    <name>A0ABY7EDV6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZN676-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_020720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF127">
        <property type="entry name" value="BLOODY FINGERS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="815"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="843"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="889"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="917"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="945"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="7">
        <location>
            <begin position="1127"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="401"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="517"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="643"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="727"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="992"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="728"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="999"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR05351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1263" mass="141679" checksum="3377978ED5122F1D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFE3</accession>
    <name>A0ABY7EFE3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5'-nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_017494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="3"/>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd07409">
        <property type="entry name" value="MPP_CD73_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF24">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00785">
        <property type="entry name" value="5_NUCLEOTIDASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="6">
        <location>
            <begin position="344"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="549"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="6">
        <location>
            <begin position="868"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR07536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1053" mass="115355" checksum="3FE46DF162B2D33B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFG3</accession>
    <name>A0ABY7EFG3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="354" mass="41116" checksum="8270ECA7A94F73F1" modified="2025-10-08" version="1" fragment="single">MSDMLTLSDADRYNNVLQMLIRCCVKVTKRLLSMFVSLLGYTCVDQFLSREKAHVLKMPSASLQKNQDILYPPSGTQTHIEKWDMSLLSCVFTHVQRKLLCYEIADPIDPVLIHYKLEVLATTVGQQYEDKLYPRSGKPTELNTWNMSLCSCLFSVLCPKPQTLYVRLAESLNSLREMRNNLCHSERLEMEHLVYEEHMPVLKEFISSGLTYIGDVAFETEIKEDMDDIEHGKMRSYVAIDHKHLQESYDSDRETSQRLDGLEKAVQQLTYQLQNDQGDKTLSMFFAKLKDDQRHLLYSSFADVFTQLVEKNAPEIVGEIHPDMKALLIHTICETWRIFDNPYGIYAFLKYYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFZ9</accession>
    <name>A0ABY7EFZ9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BIR7A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_017674</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16713">
        <property type="entry name" value="RING-HC_BIRC2_3_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01282">
        <property type="entry name" value="BIR_REPEAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="321"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="442"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR07716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="489" mass="55304" checksum="DB0064C76648D927" modified="2025-10-08" version="1">MEGIRENQFDSHGANGNLKSNVLLYQGNETRHETFDDQMKNEWARFQSFNKFQGEMDASFVRLAQSGFFYNGEKDLMQCFSCGVKNNEWPMELPVDEIHKQLQPNCPFMNKLDKSNIPIHPGDCDSETETQKVPEESASGGPDDLVTGPEKHGIPVKDFESINNKQSYDALNNAQTGFPNTSEMERETVDSIYCERRETTPIPQSCAKYPDYVSNTDRMATFISWAFSHIITSNLLADAGLFYTGVADCVRCFSCGGGMRNWEAGDDPWIEHARWFPNCEYVQQKKGQSFIDSCRLVGAFGGSDDVYSNLQDFFQTQSNTDCDEDLLKELQDMGFSRSSIDNALYNLRRINSGPVQPDEALEYLLSSAQSPLSQQPLPEYHSQKSLTPPSEDDDHDEHGHSCKYKTEVLKSEVLLEESEINPNEVAKRLKYENEQLKQQMMCKVCMDKDACVVFLPCGHLVACVECASVLRKCAICRKVIKGTVRAYMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EG54</accession>
    <name>A0ABY7EG54_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTPRB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="208"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="398" mass="45205" checksum="CC433A6E9947B903" modified="2025-10-08" version="1">MLKASVSVDNDEKQIAVALPLAQFLCNTSNGPPTMWGIVVAEADEAARDTAFAGSRDDFQKKIDDTYMNWFLVDGLNNIPPYIATKPNWKPPCANRNRRKRSSTDGSNIFVIGNDACHGPSTTKEYCNGPLPDGRSFKYMAPNMTAAFVGGAVSAVVVLVLVVLVVFLMRRRQAACFKKDTESITHTSSERFVEMGAIQTIALPGAVYLHGPVKLTEFPAFVEKMHRDSDLLFADAYKGYTSPRAYIATQGPMQATFDDFWRMVWEQNVDTIVMLTKLVENGRIKCDKYWPDVYKPKYYGDLVVSVTSESNLSDYTLRIFEIKLKGERRSVRQFAYLKWPDMGCPEFPEMLLEFLETDQFIFIHECLKACITSDRNYEEVEEHMYEQLTIMGRQHLQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHT7</accession>
    <name>A0ABY7EHT7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="35"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="253" mass="28882" checksum="6E35A2ACE1A5695C" modified="2025-10-08" version="1">MEEADVGAEKEDEYINGGTSSEDDTEFPAQKKKKTVCYWLREFPQVWNTRHENYRKTPEKDLLWEEQGQKMGLTGSHLKQWYRSTRFKFGHVKTKKGKSGSVAQPVLTFRDKTVWQLFQFLGDFVKEKANREPVASLRKRIAAQAPAHTPPRDPSPVRDEEPAPRPRGAAPPPPAAEAPDAAPVDPLVDLHRQGIQLLVSHRAALDAVIGIKGPHKDRSAYCDYLNQCGQQLNQELWSRFKRESFMFMESLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIC6</accession>
    <name>A0ABY7EIC6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat and WD repeat-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Origin recognition complex-associated protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_018852</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LRWD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0137">Centromere</keyword>
    <keyword evidence="11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0779">Telomere</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="900"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="65"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR08894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1001" mass="113962" checksum="5224205907327FD2" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIJ5</accession>
    <name>A0ABY7EIJ5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PCR4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cornifelin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="110" mass="12249" checksum="EA26FBBFADA3576D" modified="2025-10-08" version="1">MSQGQWKHDLFGCFSNINLALQTWIVPCVTYGQNTEGAELCSCVVGGLAYYVPGYNLFLKAKTREAIREKRGIPGTFGNDCLMSICCGYCTLIQENAEMFEQTSVNMARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJY0</accession>
    <name>A0ABY7EJY0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="9"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="118" mass="12939" checksum="87C86AF12DFEFB60" modified="2025-10-08" version="1">MALKNVDSGPTNIRIEERLPYGVRLTWDIPETPTCYGRVEIALVVYLGNGQTRVIQVNSEQNSVDVVGLDPDKEYSVSLKVGYEGTELAALPYAFKTAEKENHLQGGIIAGIVVSKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKZ7</accession>
    <name>A0ABY7EKZ7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_034760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR09684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19480" checksum="B121CC9C8AE66FD8" modified="2025-10-08" version="1">MEQLGPKLKCTLKMEYIQFLNIETWVDTFLTMVIPFFIIILVNSLVLRTIIREPLQTMHSVVILKRKKPHSAHKKVDTFVILGSMKKTFCKPTNPQIRVTRTLIMVSMTFLCLNLPSHAVTMVLYYVTFSCNFVIYTLFGRKFKSSLMLILKCRSTTEEQRRLLLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EL94</accession>
    <name>A0ABY7EL94_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="110" mass="12636" checksum="9397358489C1CE25" modified="2025-10-08" version="1">MRQDARDTTLECYYLRCTDGNDQKYKCPKMFFQVTETEWYAEKSISECHKPGICFGQMAVVSLGLLQIQIDVPRRDQLFLTGCVPQLSGIDKNKRHLLVKSPDISHTCGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELG2</accession>
    <name>A0ABY7ELG2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAT4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_019431</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046683311" evidence="3">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR09473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="109" mass="11443" checksum="E82A833DDA6EAC56" modified="2025-10-08" version="1" fragment="single">MKKLFLALLTISLVQWGESIDANACQSSPCVHGSCFSGPAGYLCVCDHGYTGIHCDSSIDISVSGGPTCYSCSNHTTKDSCTDIQHCPAGQDCEAKVAALTQGILGRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENG2</accession>
    <name>A0ABY7ENG2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_035342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045504828" description="Cadherin domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="3">
        <location>
            <begin position="70"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR10266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="236" mass="23560" checksum="3E4E994D7B774001" modified="2025-10-08" version="1">MLKGTLVTCLIVAVCLLQGYEAAPTAWTSPGVISTAGGSFTIPAGGAKAEDIAAGTVLFTATATVVGTPTYELVDDAGGKGSIVAATGVVSLATGQTLDYETAATLTFEVKVTDSDDSAVGTATITLPITDVNVAPTYSNAQNTACVLNNSGAAGDTNTDFVYGADGKIKVAASKTLAMGTMAKYTLVLHAVDDDTPAFTASTTVTVNVKTTCNGAGAFGTMFASVLLAASLSYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPM2</accession>
    <name>A0ABY7EPM2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026065</name>
        <name evidence="3" type="ORF">MAR_026118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR11938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="213" mass="24203" checksum="8CA5B6E81DEC608C" modified="2025-10-08" version="1" fragment="single">MTETPINRGAPDLVLSTRRESILRTSRFGTPYRTPNVRRFGPTGATWRTSAAHSKTTQLSARRTSTPLNTRTKGQRDSALTSTPLNPRAKRSEDETFSQITSRTEIEENNIKHDSKALLIQIKGKKRYKTEEKVLCEAVLFSTDLEYNPLKQEQQSEFTYFSTALIHGPVVLSETLQNWLEPLDLVYGIPAEVKGISQIDYSTQAQDCLRLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERJ1</accession>
    <name>A0ABY7ERJ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="210" mass="23479" checksum="409F6D7CFAE1A5BB" modified="2025-10-08" version="1" fragment="single">FPVHSYFIETQPTVWGNASCQIAFPVLNFSGSTPSIDSTEDISNLRIPGNGVWIGYYQAMVTYTYVGNGRRDQYEGQIYDVQSLGDCISATGCKTFGLWISNTGLTCKCALGYTVFANISCDSHCNDSNFKFPCGMAETNIMSVYNTDNERIISQTDDTCTSIECSCLSFTYNNTPSDAYIFKWKTCMDKEFSFQPLCNNHNFSGIWLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESD1</accession>
    <name>A0ABY7ESD1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">VLDLR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_035182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR10106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="338" mass="37843" checksum="E6806A269DD2AE53" modified="2025-10-08" version="1">MPDAVAATCACSYGKLRADNKSCEALKTFLAVMTENSIAGIDLDLSNTVEAIQRINGTFRNSIEFIYKENALLLQDTRRNEHIIETSFIGRLKARRTCDEGYFKCREGRCIPTDFECDYDQYPPCQNGTFMCRYGRCIDNGLRCNGVDNCNDGYATDEADCHEFKCEGSGRCIPNSWKCDGDEDCNLGEDEPPKRICENITSSCSDKDFRCANGKCIATLFVCNGINDCGDNTDEKHSLNCSSRPCPPDSFTCKKNKERGIYPCISSDKVCNGVYDCLEKEDEHECPVVLCDEGYFTCRSGECVPEKVKCDYVLDCEDGSDESTKCSKMTYTFSKNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETC3</accession>
    <name>A0ABY7ETC3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAPEP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13483">
        <property type="entry name" value="Lactamase_B_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="386" mass="43738" checksum="6F3CCCA8571EB1C0" modified="2025-10-08" version="1" fragment="single">CCCNSCDCANTYTFQAIQKVHPVLKYDIKTVKNPPHDSIQITWIGHATVLVQMEGMNILADPVFSNKCGPGFNIGYTRFTPPACKMEDLPRIDVVIISHNHHDHLDTWSVRGIAELHPKAKWLVGLGNKKFCVEKGCADVEELNWWDPTIVDGFIYSMVWMDSGKPKIQLIGQKYGPFDLASIPIGAYEPRYITEFQYVNPEEAVKVHIDINSKISVGMHWGTFELTDEPPQELERQMYMKNLDPKTFFNLQIGETWIVGENRDYDPPFMEREKRGTPRLNYDRPNGDLSGFTTVATLQDPLSMVDALCQDIKTENQVKKIECSHPRRISPDGPSSHNNHTDLATLTVKEPSAPSKRSMARDAQWPHNTQEDSASVVKPTGRSKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETP8</accession>
    <name>A0ABY7ETP8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MTEF3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_025959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF112">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR11779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="471" mass="53802" checksum="90AC5DEC8139DEFC" modified="2025-10-08" version="1">MYPNCHLKKVLNNMNTVKRLHCSATYCVHTSTILKEKASELKPSDLEQEKQNEKNGQFDDILDKAVQEAPKNLVLDWDLYDHDNKAMVSNHGEVTPAKVRSEIERWTAHQHKTMLQKVVDGNYLDKYGSIEEAHRSPEYVLQKNEELEETEKAKSLTNQRKMRLLALRQAIIMADKEVIGSSQNQQIVPTSESEGQECLELETTDKGLKLSEMPIKVAVPVLPNFLAIYAENKLLQQLVELGVDLSAVQKAGLANHVLNLDWRKQIKPLVINLLNRGLSIEQVGPVITQCPHLLTENLQNINVRLDYFLSKRFPRKVLTAMMLKDSTFLAMPVEKIDSILGFYQKLLNLTAVISLRNELEFSEEEVKLMFIKHPELLLARRRVVVTNCDYIQEVMGIPHRMVVQFPQALTGPHHIMSSRHRFLQLHGAAQYDSCLPGYVSLNDLVEKNDDLWCSSVAKASLEEYDAFLKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETZ1</accession>
    <name>A0ABY7ETZ1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_026609</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF5">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 44 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="11">
        <location>
            <begin position="39"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="12">
        <location>
            <begin position="324"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR12429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="46684" checksum="F219343A67920757" modified="2025-10-08" version="1">MDQNSEGFSARRGMMHADVEYLQGLGVGLANLRASGQFCDAMVCVGSTRILVHKVVLSAASKTLHDLALDFDMMSHRERDQLEIVIPPDISLYAVNMFVNFIYTGQLELNSRIVGHMERLGTLFGISRVLIQCREFIQRSTTPDSQNLNLQTTEADSSLNGAMPVGSEHRLSGTPDASSHLTELSRSNSACSGFSADMGTGFGMANVKTEPAHFASYESEHQLKATADGQDRNGQDKTNMSMLEKLMSPRVNLKKLPSNITPDVVVMVSDDEGEEGEVVGKTPGQYTLEEKEAVAVEAKRYGTTQDILSWMTLFGLRHPGGLQKVDRRGKQPDHHADLALVRWIVQQQELNGCVDLNSMKQYALTVHKETNPKFCASKTWLGNFLQRNMAVLQGTKFVQGDKMEVNLYEAGDSDSDGVIRKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EV17</accession>
    <name>A0ABY7EV17_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="234" mass="25170" checksum="1AF3EC1B237CA381" modified="2025-10-08" version="1">MGLEINFRASHVATQVGAVVLLVTFLLYVVGFATNGWAYSKTGSIKKGLWKICLCSNGSFGSKTCICTDLIEKDDIDLPGAFILTAIVLFRVKLFEGGGDDIYDLQYSYYLCTTVVVIIFVILIPLLVVGHIKTQSNLAAVGIAHQGFVISAPGHTAPSYGQQGMAYPMMSYPTEHGYTGVMYPMSSHPVGYGHQGLPYPITSYPAGYGRHGVLNPITSHPPEYGNHGDANTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVD8</accession>
    <name>A0ABY7EVD8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="240" mass="27973" checksum="73DD1730265494B2" modified="2025-10-08" version="1" fragment="single">KIKVEDNKVANEYLSPNGFIFKFSIFIFLLKVLSIHFKVFVSSSMETIVLILDDGWCSNANLETAGYKINTHGNVCLLQTKPFFKLIESRLGLDHVLNMHERFNILFNLWYSIFRCDRSADVAFLRCENAVAYKCWSKLEKQERDRELLAIIFSLHSFRSNLAGKRIIEKGSMRTELNRMALDIFSSFASHCISIKTCWIERERETEADELSRSDNYDIFGVTIELFEYINNWKGPHAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVP8</accession>
    <name>A0ABY7EVP8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NETR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_027209</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046408229" evidence="3">
        <location>
            <begin position="24"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="122"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR13029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="242" mass="26734" checksum="40EBD64496D6F39C" modified="2025-10-08" version="1" fragment="single">MAVCYMILNLICVFCTFCNFVVSEESQFFLFEFDQVCQDTVYGDVLANLTDVNNVQCGVRCADDVKCKSYTFDPLTEVCIMNNDTVNTTTIGPCSTFVRYAAKRGWARCVPGSACTRPIRGVRLCDGGGLGVCNATSGRVEVLMNGQWGTVCDDFWNDPSYYNPEDPYYYGNMGFNNAHVLCTSLGYTTGLPMPDGYYGEGLDPTWLDNVSCEGWEEHLFQCVASPVGVQNCDHSEDVGVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWR3</accession>
    <name>A0ABY7EWR3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="639" mass="73160" checksum="EDBB34C5E0410CEE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2Q9</accession>
    <name>A0ABY7F2Q9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Forkhead box protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_005764</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd20028">
        <property type="entry name" value="FH_FOXL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047515">
        <property type="entry name" value="FH_FOXL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF411">
        <property type="entry name" value="FORKHEAD BOX PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Fork-head" evidence="12">
        <location>
            <begin position="191"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="10">
        <location>
            <begin position="191"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="155"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR15659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="432" mass="48359" checksum="F5D6231B9D246782" modified="2025-10-08" version="1">MDFTSARYTLSDQNSKYQVGNYFSSEQVCDNTNLPYPKYGINTISSSTHVRSFPEFSSNIADHSFGSELDKVVSEHCDDLEDDMGEPEPLVSHEQKLKRLNHDILERNCEKSNNVTNNAGLQMVTSECDKYVNENLRHTDEQSAVMEETNYIVKLEKMSPDTGSKDTNKVTSSTEKKKHESKNKDQDPNIKPPYSYVALIAMAIKESGEKRLTLSGIYQFITNKFPYYEKNKKGWQNSIRHNLSLNECFVKVPREGGGERKGNYWTLDPAFEDMFEKGNYRRRRRMKRPYRPAIALSKSFFGDPTHCALGQFPFAKNYFSPPPYSQYSPYHSWALPGHSPTPGPGAVNVNYNSCGQGRSMGAGSTLGSCGYSSLNTGFHLGGGTGSGYPGQLGEYGAMASPGALTFSCRQQTEPFNPVTIRDILGFSFVMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2W6</accession>
    <name>A0ABY7F2W6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_030669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047548767" description="protein-tyrosine-phosphatase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="251"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR16075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="466" mass="52725" checksum="E8F985D53BEE9A7D" modified="2025-10-08" version="1" fragment="single">MEVRNGLLEIVLFVAFGFCLCGGTKCGSNCLDCDTSGASGSCLQCDDGFYTSGFNCIPCSYAKCQTCSKALHCDTCPDGFWGDICTAKCADGCIDGKCNTNNGSCSCRKNFYGNKCDGKCSDACEPMTCFGDSGNCACKQGYFGASCRSKCGNYCADGEHENRMRNTQTVLVTNITQSDLFLKEIIKRKHHHRHQDIVLPDLDEERRTQKRKLAKKVEENVYYIRLQDIEKRKVKVEEMAAFVDEKTLAYYEEEFDKFSDGLTRSCDVAKLPLNRAKNRYKGLYAYDDTRVKVTGFDTDYINANYIDGFKERNAYIASLGPMSKQMGDFGMFWNMIWQQKVEKIVMVTNLMEDGKEKCEQYWPNVGITINYSGVMVTCQSENEYADFTRRLLLLNDGKSERQLHHLHFTAWPDRGIPEDVTALIEFRHRVLHSPALLGGPTLVHCRPLLSFKKEPFESVAERSKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F300</accession>
    <name>A0ABY7F300_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHST3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="272" mass="31874" checksum="18A1F6965F922D2F" modified="2025-10-08" version="1">MLVAYKRTGSTFLGDLLGRRADVFYWYEPLAKGRVRNYFKERNLLFYVLCSIPEVWKPFVDCFKRKDESCAQVLQDSCKHSEHRMVKILRIDVKSVGSMLETNPRLKMVLLFRDPRGSMNSRLTTAFYQKYVRNISQISNNADMLCSRMRADMSAGKKLKIKYPGRVILLQYEDLDDSENKLNKLYDFLNIEPPKQRTVTVVKNGEHVNDKPAGFHPFSYRHEMPFHVNQIMNAHCSDIYKKLGLRKFENEDNYKNDKISVIVNKLPFAILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F320</accession>
    <name>A0ABY7F320_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TEuncharacterized</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_031144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF9">
        <property type="entry name" value="MULTIPLE EGF LIKE DOMAINS 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR16550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="344" mass="37685" checksum="7616BE680F8F26D0" modified="2025-10-08" version="1">MGIGFYGRDCLHDCSGKCKGYLCEIDHGNCLECRDPNFTGGRCDRCVNGKYGSECELDCPVNCLSCESATNCTECKTGFTGIGLQCLLRSDCPENCIGYKCDSTGKCDSCKDGFYGEFCMMNCPENCIDVICNRNGSCDACRDGFQGTFCKITCPQNCKQCHQDNGSCSICENQAWKKDCSRKCSSTCRIDATSMTSCDIVSGECTFGCVSGSHGSYCELICDERCGSSRDGIKACRQRDGFCVEGCERGYRFEVTGCLPVTDKPWDESSVLTVGVLGGIIGLLIIALAVAIGRHVIAQKDNFKEIKPDEEARTYEEIPEQTDQPKYQNVNTNNYDMLFANSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F6K7</accession>
    <name>A0ABY7F6K7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ASPH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_032417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartyl/asparaginyl beta-hydroxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007803">
        <property type="entry name" value="Asp/Arg/Pro-Hydrxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039038">
        <property type="entry name" value="ASPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12366:SF29">
        <property type="entry name" value="ASPARTYL BETA-HYDROXYLASE, ISOFORM L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12366">
        <property type="entry name" value="ASPARTYL/ASPARAGINYL BETA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05118">
        <property type="entry name" value="Asp_Arg_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aspartyl/asparaginy/proline hydroxylase" evidence="3">
        <location>
            <begin position="209"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR17823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="357" mass="40856" checksum="A000409FEE4D921D" modified="2025-10-08" version="1">MAKQKPKSSTPHKPGKVEFTQLGLNPFQEVLNLNDDTTPDDYVMHQEGDTLKKDPKQDAHDKLRELDKNAINRNNDLTQDKQDTGKETESDKGSKKDKPRQEDYGKIVITSKGDYKLRKKLDAADKLLEKGEVAKAMEKFDAILRNKSRSPRAMWGKALATDKLAEQQKSNKLLEEAISLMDEALRLSKTPEALQLIIAEKLADRQAFRGAFVPEEENLRETGDWKQFTLYQRGRKNEENCKKVPKTCSLLDRIPDAKGCTRGQIKFSVMHPGVHVWPHTGPTNCRIRAHLGLKVPEGPKIRVGNDIRTWKEGKFIIFDDSFEHEVWHEGTELRLVLIVDFWHPELPAHEKRTLSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDE0</accession>
    <name>A0ABY7FDE0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TALD3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029246">
        <property type="entry name" value="TALPID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15721">
        <property type="entry name" value="KIAA0586 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15721:SF2">
        <property type="entry name" value="PROTEIN TALPID3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15324">
        <property type="entry name" value="TALPID3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="943"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="808"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="961"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="979"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1196"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1260" mass="138979" checksum="14775496D43D3305" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FE65</accession>
    <name>A0ABY7FE65_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CNGA3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_002208</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF13">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="379"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR20370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="448" mass="52299" checksum="C8640936CCC5BA65" modified="2025-10-08" version="1">MRPKESSETEEDQPDLELGIRRSTSSRNSRIEDLTVSDIILDPDGIIVYYWLGIVTMAIIYNIIVIALRVAFNEMRDQANEESFFPLLETTVDIIFLVDIAVHFRISFYEEGCLVLDPGQIKNKYMHSREFMIDVISILPMGYFYSFASITSNLIFLDMESLIPGKLQILLVRAPRLLKYSTMVRFFDLTDSRTRNPNLLRAFKLSLNLWMVIHWIGCVYYLVSEFEGLGTNDWVYPNGTEYDVFLRKYIRVTYWSLMTLTTIGERPPPETDMEFVFTGVTFLIGVFVFAAVVGNVGDVISNMNAARTEFQSRMDQIKSYLQHRHVDEKLQNRVKRWADYTWNRTQSIDEPSLLHMLPDRLRTEIAINVHLETLKKVKIFEECEEGLLRELVLKLRPQVYSPGDYICRTGEVGKEMFIVNHGKVEALVEYPNAKRILEEIARKRYYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FH08</accession>
    <name>A0ABY7FH08_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SOCS4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_001869</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF0">
        <property type="entry name" value="SUPPRESSOR OF CYTOKINE SIGNALING AT 36E, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="360"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="8">
        <location>
            <begin position="450"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR20031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="509" mass="57768" checksum="11A5E2B038EB6664" modified="2025-10-08" version="1" fragment="single">MASGGEASSKMSKSKQEVKVKPRLLSTRHRLHRSSVRPFFCCGSQLSLNSITEIKDLPVDKGKSIEDDYVDVSDSDDMLEDLDNLHVSHAAVKVELPTCTRGANSKRKKLGNQTNSRKKFWTVKLKGKLTVSKRSHFGSDSKLSATQVENEGASCVCTSLKSLQSLPSADREFPPNTDSRWSLSGSRGNVMPSVSNNVGLAVDLDIRQRSSRDRPLRNFNQPLPFIPNFNTLYPINDIDEQRIAQRRYEMEHGIYERENVEDVWVLGSQQETEASEPSGDTEGIGQYPSYGAMGLLSPGLVQGQVANELHVVGRGLLEVLSVQPAPPWVRNIPRPTGVHTQVDYKHFLVPDMDRIVNSSFYWGVMDRYQAEKLIENKPEGTFLLRDSAQDEFLFSVSFRRYGRSLHARIEQWNHKFSFDSRDPGVFADDSVCGLIEHYKDPSCCMFFEPMLTLPMHRNFPFSLQHVARAVISSRVSYDGINKLPLPISLKEYLQFYHYKQKVRVRRFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FH73</accession>
    <name>A0ABY7FH73_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mab-21-like HhH/H2TH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_001901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF69">
        <property type="entry name" value="MAB-21-LIKE HHH_H2TH-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="2">
        <location>
            <begin position="288"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR20063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="566" mass="64901" checksum="9358BC91EE89484D" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHY9</accession>
    <name>A0ABY7FHY9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="97" mass="10526" checksum="B175F7B26FA41C13" modified="2025-10-08" version="1">MITAAPPTNQTSDIALPNIILTGGSSALSIVGALFIFCSYSFIPPEKRVQNCSGHVKTEEEWLCKTQSILTTASNMSSFLWTLVIAVHLWASVVLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIN3</accession>
    <name>A0ABY7FIN3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_016029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="248"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR22055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="480" mass="54511" checksum="DC97531C07549791" modified="2025-10-08" version="1">MALENQKMFQTIAAIELYHAQREVANYLELAYLHLADHTDVAREVRMTAHSARTQHLMTSGLMKKFTATSFHIVKTMIPIILDAVELQDRDIIIEAFGQIIENAETMKKESEDTRTSYLNIQTDIQRNLASVNDRNKDIVDKKKKIEIEKLREEEMAKAAQLAQKELDQERKRIDDELKTLKSYRDRMYESADAAGKAMTQDNDTTFMSSVGPSEAMVGPSAFVMTIATSLGNILTNVFKGDRKMKMYKELQKNYQASEENVHRASQERRQVIDRVNEQRKEALIRLAKLKELTLQEASLGNVESLREASMQLGAVDKQFTRIILFWENMAATLKFLKEDVKSGEVYLKKIEEERYAERFKKSIGKAERDWRFFGRICSDYVQESDTQINHLYNFLSSPVDHMSTYDRDKRQQAILDSIESDIASAFVVVVVVVVVVVAAAAAAAAAAVAVAVAVAVAVAVAVAVQQQQQQQQQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJT6</accession>
    <name>A0ABY7FJT6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001349</name>
        <name evidence="1" type="ORF">MAR_009279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR02721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="83" mass="9243" checksum="79009E7559F95EF7" modified="2025-10-08" version="1">MSTTDNSVKMCCKNMFMTFTMLLNLSRVRETTKTVSTPSVKTSIKLSALIMEFMHKISPGQHKTQHLSLINSLEGVAAIIIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJX5</accession>
    <name>A0ABY7FJX5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="19" mass="2344" checksum="C1559FA408C18E32" modified="2025-10-08" version="1">MPDKMEIKWSSKIFSQMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FK24</accession>
    <name>A0ABY7FK24_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_016517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR22543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="101" mass="12101" checksum="5CB0824E985952DF" modified="2025-10-08" version="1">MKVMDVIKAAVANNCRKVQEGITKVEEVSAFWETQQEQQASYLQFLNITEVNTTSDFWREQEIIQSRYMDFLKIQELPKQIHEILHCERDKNKTLKKRVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FM85</accession>
    <name>A0ABY7FM85_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_015762</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF9">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="470"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR21788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="788" mass="88668" checksum="CE37431FAC70A62C" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMM7</accession>
    <name>A0ABY7FMM7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047470001" evidence="1">
        <location>
            <begin position="20"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="179" mass="20359" checksum="4FABD36A42AFF547" modified="2025-10-08" version="1">MSQVLPLLNVFVGLISVDGNLVRPVCNGTIRTLTTRGCNTSGRRTQHFTEHLTNIREGAEHLYVQYSNTADDFITLHKIASVISFVHDTETDDIFLAKMTSLQHHVFKSLCYLYQKGTSCGLLLPFHVHMDTVSHSNCDVGDNLLIKYTRDMQLFKRMAENAREIVYRYTCGDNCGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRH4</accession>
    <name>A0ABY7FRH4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="97" mass="10516" checksum="EC9E4B40199DA422" modified="2025-10-08" version="1">MITQRNSEPSSTKCDSSGVVPLTDGITYADNTTKANMLNDQFSSNFNKNKTVISMKDMGRSPHPKLPKINIAPVGVKNLLCDFQIRVAGHTAPISLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTF1</accession>
    <name>A0ABY7FTF1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_016470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRCR" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR22496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="136" mass="15113" checksum="D5A1E8E588BE3E7A" modified="2025-10-08" version="1" fragment="single">AIQIITDTTYGPGAGPILYNQVNCSGSETSIDECASISGEQCEHNQDVAIFISFITLLRRENCYVPDVIRMLFTAFPCPRAAEFYYGDFSRVALTAEGQEYHGICSNGTYTYDFTYLCLENGTWIATHNYCGPLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTW9</accession>
    <name>A0ABY7FTW9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Tartrate-resistant acid phosphatase type 5</fullName>
            <ecNumber evidence="2 6">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_037973</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2 6"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd07378">
        <property type="entry name" value="MPP_ACP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024927">
        <property type="entry name" value="Acid_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000898">
        <property type="entry name" value="Acid_Ptase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046172770" description="Tartrate-resistant acid phosphatase type 5" evidence="7">
        <location>
            <begin position="17"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR24304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="316" mass="35871" checksum="C82B43C4716D7151" modified="2025-10-08" version="1">MIRFMFMCIFLREVSCMDSLRFLAVGDWGGIPFWPYDTPIETKVAKQMAKVSEMYQSSFNLALGDNFYSNGVTDVDDKRFKETFEDVYHYDSLMNPWYIVAGNHDHYGNASAQIAYTKRNFPDYYYSLNFKIPGGDGVDIIMIDTVLLCGNTDHDIVGDQPHGPENVKVAEDHWAWLDTQLKSSKAEYLLVAGHFPVYSIAEHGPTKCLTNRLKPMLYKYNVTAYFCGHDHNLQHISSSESGWTVDYFVSGAGNIVEDNKSHERDIPAGSLKFFWAKLIDLGGFAVVEATSKNMTMSFVDGFGSTLYSYTMYSRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUL3</accession>
    <name>A0ABY7FUL3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GSTA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="167"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="311" mass="35517" checksum="2289EDA0731439CC" modified="2025-10-08" version="1">MLSDSAHPLLSDSDHRLMLSDSDHPLLSDSAHQLMLTDSAHRQMLSDSAHRQMLSDSAHRQMLSDSAHPLLSDSDHRLMLTDSDHPLLSDSAHRLMLTDSAHRQMLSDSAHRQMLSDSAHRQMLSDSAHPLLSDSAHRLMLTDSDHLLMLTDSADRLMLSDSDHRLMPTDNAHRQMLSDSDHRLMLTACAHRQTLADYACRQMLLVYYHWQTKPEDRDDKIIKERMEKAKVELGYWEKALNGHAYMVGNNFTLADVAVYPFLAFLMRMGASFREFPALLKYYEAITKRPSVQATWPPHWKEGTTDPILGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWF8</accession>
    <name>A0ABY7FWF8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="284" mass="31232" checksum="255E05E837EDD8DF" modified="2025-10-08" version="1">MAEVSRGEEEDVLDIGDNRYVVEDNRCGQRGRRRLLSTDSSECESEQMLLLSEYEDSDIHYRSSSENELQSPSQHKTGMTGRLSNGSENDESEEPEDLNINEDQTMSRYSMDVQFSDLDTSLMDASVTILIRFEHVTGPPDVDTTTPRLVSVQDITSLVSNELVAAPKDMEITTHEDPRFVRACCKTADGDNSCPSLVHGPVSDLHSPLETANGDTSCSSLVDEPDGALPLPLETADGDISCPSLVHAPDGALPLPLETTDRDYFVSQLGPCARWCLTFTIRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWZ7</accession>
    <name>A0ABY7FWZ7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclease HARBI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14420" checksum="EF031C60BEC2397C" modified="2025-10-08" version="1">MKQTMYVGRFPNVIGLVDVTHIRINAPHQYEEDFVSPTEILAKNISCSFLHNFGLDHGDVFDRLGGIDVDQPDHDFPVQIKNPGNCLLFRDLLARTFFSRLIFGFLFLKGIVTVMTVFESLKNKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZ63</accession>
    <name>A0ABY7FZ63_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="112" mass="12656" checksum="9C56A6617BF20045" modified="2025-10-08" version="1">MAQFMAFLEERKYLTHQLSILVPDPSTQPLLTMPTKGVTNVKASRPWHAMVTNVPRITQNTFLPDLSMRKPNSGDAIADIMYTRLETHIKHTFISNFTCTDAVCSFVKIAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZZ4</accession>
    <name>A0ABY7FZZ4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHSTF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_013244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052654">
        <property type="entry name" value="CS_Sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15723">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15723:SF0">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="2">
        <location>
            <begin position="190"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR27540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="300" mass="35495" checksum="AE29EFB2EEDD1B79" modified="2025-10-08" version="1">MDKVAQMLGKIACFLFLVAIFIIGKYIDENKTKYSSNLNSVADSVNIADSKPAVRVLEKIGNYNLTTSTTGVNLRNLGPFHFLPNHKNPCWRRIESNKTLTRCIPYFYLIGCEKCGSSDLWYRLLQHPEIAATDKETLHWINKNRFHGLPFEFYLDWFQAAVEDFYEECRRTHTDRYCVNTKKPEQSRIGQIWKGIYYIHFGEFYRVFPKEQILVLKLDDCKINYDECLNRTFKFLGISPVTEEFYKALNTNYTVKNTRQYPARMWNSTKRMLEEFYKPYNDELVKMLGPHFNFSTKYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2B5</accession>
    <name>A0ABY7G2B5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TYR3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_013098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="53"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="100"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="154"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="215"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="283"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="323"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="283"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="323"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR27394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="357" mass="39698" checksum="83B3C43CA2168479" modified="2025-10-08" version="1">MSCFKTQQKQCKKVKKKCFCYSLPRYMITKKNKLINTFYSLCISLYCTSLATCEDHYETKLCRVWKDHGECIVNNKWMHKYCRQTCNACENSGPDPDVACDNKHTDEAECHKWAAEGECQMNPAWMPENCKKSCHMCGEQTPIFTTTETPKPECKNTWDDDQCSAWARDKECIKNSVWMNTNCHRSCTGCGGGSTEAPRPTQSPVRTTTTSSGDCVNNHRSDEECVTWAQYGHCDINPWMKIHCAKSCKTCTAPEVKTTTTAKPDNGGGGGGGGGGGDNTSGCEDKEQYCPSWAQHGFCEDNPNTALRICKKSCKACNAARTCKDGHALCPVWARGGQCTKNSGYMLRSCQKSCEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G301</accession>
    <name>A0ABY7G301_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="79" mass="8916" checksum="0E2BE079010CF308" modified="2025-10-08" version="1">MTERRQHQMSDKKNTSALLPVAMATLFQSGCFLGVGILRPTLTFLPKDPVTLIGLVYGLAAVDMFVYFYYKNGRNNKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3B5</accession>
    <name>A0ABY7G3B5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19785" checksum="D67F6C7D887C700D" modified="2025-10-08" version="1">MSKINIMVMDQDDLGIYEIVIENDVGYEKRAVNLVPKGEPSPPHIISITYVTKSSALITWTRGFHGGFDQTVKVETSRDGTSWTPTLSLPQGTLEDTSPGGDNPGYNAAVTYEVVSSRKDTPDYDALQDGKEGNEDPHVYMPLEDSNPKSHAYYEYVNRGTSLVIVRSRFRIKISVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4T5</accession>
    <name>A0ABY7G4T5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="99" mass="11150" checksum="E8E3D80214D50BEB" modified="2025-10-08" version="1">MALCWNFACIYLFYAFHFVKGLETQKPTLIATRIAANNTITLTCNILGGTARSVGWYRNQGRMVISIGYVNGICKTSPPELPFSTECRFNLNRITEHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6I6</accession>
    <name>A0ABY7G6I6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IFI44-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFI44 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241:SF32">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="6"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR29760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="465" mass="51115" checksum="452F8F26545E17CA" modified="2025-10-08" version="1" fragment="single">MHLKRFRMAGKLTKEHMNLLESMIGCGPKSFKLLYSITRDGCSAAEFHRKCDNQGPTVTVLYNPQGSVYGGYAGLSWKTDGGHAKDDTAFIFQLMFSGKRVVNTFRPNDASKALYFGSNRSALFGNLDFEPFFGTISMDKDGTFPLNGNLALGTYQNSNNVSNDAINNGSMVVTEMEVYAVSADDARTSTPKQKTWRKTPALNEEYLSKMTEELAALTPPKGSGVTDFRLLIAGPIGAGKSSFVNTVMSAFAGRVMHKAVVGGSENGLTNKYMSYPVRQGDGPCLHFRLCDTPGIGEHSAMDVVNLHFLLDGHIPNSFQFFPSHHVSIKTGGLIQQPTLSDEVHSVAFVLDASTLSDMSPAVKIWLNDCKRIVQEKGIPLVVILTQIDKLDEESSRRQATVDKASETLSIPPNHVFPLQNYHTEVETDVSIHSLALMALQKMIFMASDFLEGRMFSREECPTEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6U1</accession>
    <name>A0ABY7G6U1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="63" mass="7150" checksum="26F5DECBEB0B39AC" modified="2025-10-08" version="1">MTLNLPRPGCNNPVENFTTLQEKCEGDLHLPFYVSASDAYKNEFCALCRKLVIVDNFIVRMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G832</accession>
    <name>A0ABY7G832_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="90" mass="10172" checksum="7B010895D01C1017" modified="2025-10-08" version="1">MLKYKSLKDSPIIISAKIRAHSFNMTEANSKDSAAFQMQKGAKGDNLEDLFSTLKQQISSSDWLKENTAEKWVKENPELAKDYMDAAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8A1</accession>
    <name>A0ABY7G8A1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="98" mass="11031" checksum="DC2F33DD6973843C" modified="2025-10-08" version="1">MKECLVRKEEGTCEVPLTGANKNTGFLECDHPNCMMCPDGISEQSANGYNFNGCRTGFYRSRYRKCTDKIEGSYTHTGMRTGLTGQRERIHTQVNALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9K1</accession>
    <name>A0ABY7G9K1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_033629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026:SF10">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="117" mass="13448" checksum="1D933AF3C9C70AE9" modified="2025-10-08" version="1">MDGGKEICIDEQFKPKPPCLIDIEGDEWYSIPQMISSGALDDVKQISMETHYIQLGGQLWGSHPIPEADELYTLRLLYDKGFRIFMRERNLSSMMMWPGFNNSITSVNEISLIKSMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GA89</accession>
    <name>A0ABY7GA89_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GBP6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1000.10">
        <property type="entry name" value="Guanylate-binding protein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003191">
        <property type="entry name" value="Guanylate-bd/ATL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02841">
        <property type="entry name" value="GBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047155333" evidence="1">
        <location>
            <begin position="24"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate-binding protein/Atlastin C-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR30249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="217" mass="24927" checksum="9903729307A91996" modified="2025-10-08" version="1">MIAERIFSFLTVLAVLTNQYVDALRNGAVPDVENAFEAVATMENAKVRKEALEQFHKDLVDQIMPVPYKQLDDHFQRVQWTALEYIRNNVVKDTKHSVEKHVQSDMEMSWLQRKSVNEQHVIELCEKSLEALPSTSNLVESIQAKSYAVVGGHKQFKLDSELVGKQYHSMLKDKGYTDREMAITWSTFIQTLAEAEMEIIQLDNSLSEEEKKSTYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAA4</accession>
    <name>A0ABY7GAA4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TRIM9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_033887</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="220"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR31345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="796" mass="87459" checksum="0E582C9592CB22BF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAU6</accession>
    <name>A0ABY7GAU6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="84" mass="9552" checksum="4ADE53DB46EBBCB3" modified="2025-10-08" version="1">MNVIRSHGHEIFTEEVNKIALSANDEKRVIQEDGVHTLAYGHWRLRLKGSLALLPGRWGIWGANLDFWPRSGNNLLLTMASMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GD43</accession>
    <name>A0ABY7GD43_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="69" mass="7567" checksum="473140F3651B184C" modified="2025-10-08" version="1">MFVMNVFCNLCLPGVRVKSSNGKVKPKNEAANGKPQSKGNNTYSEKPKSAKPKSARKNTPVTVVEESEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GDN8</accession>
    <name>A0ABY7GDN8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MOT12-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_033623</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="69"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR31081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="297" mass="33022" checksum="AF0174DA6147C6A0" modified="2025-10-08" version="1">MLEQPREDNLHATNGLSYKSEFTSDISKPLRRKSVLEEKLGQMKSLLKSNVPKEQRKPFLELSLLKDFPFLSLCIAILLYTMSMMSTFVFLPPLAKSKGVSQLQAASLVSIIGISDSVARFTSGFVLDMKRVKPYRVLVYNGVMFCVGIVSMVMPSLESFSEFAALSVMFGILSGTYVAQKSVVVVDFLGLEKMASSFGLLLGFQGIGSLIGPTISGLLRDVFGTYDEAFYFGGIGIFFGGFVLLCGNVVKFVRDRRRRRQEKADEEEEGEEEEDEDEEGSSDNDNGEKREKSHETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GE44</accession>
    <name>A0ABY7GE44_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_033773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="651" mass="78609" checksum="A6D3A5D15A260F44" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D7K8</accession>
    <name>A0ABY7D7K8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L3BPA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_006130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF27">
        <property type="entry name" value="SCAVENGER RECEPTOR CYSTEINE-RICH TYPE 1 PROTEIN M130-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="346"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="129"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ93659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="460" mass="52128" checksum="C25FF16F8D3C3884" modified="2025-10-08" version="1">MACFRAYDPKALSKTDVGYGDMRPVLLHLIFCLTILKPIGGSRLGRLEDDVKILKSYIYRELSSIRDEVKEISNRVDILENITVTHDPGSPNQDMDITSYNLADKTGESEKQLLRAGNNIGSQAVKAEVQNIRKAYSNDKQNLHKLKNDVEGQLKELEQKITSHMHNLTLEVQHNIEYIHKNISLANCNLSEFINGSTTNVSTFSQNIKMEINELFANTSQQLFLQLNLTEAKIKLNISSTYSQNEDQLDSFLALAERNVNEMMLKADTIINLIRSNFSKIPIQITDLSMELQSIKNEMKGVEERLGNEFESSSSVLEKEIVLLRTCINTKGIIQNGFYYPCEKDIRLANASPYRSTGVQGRLEVRHDNEWGTACDDSYEKQPDVGTHYVTDNVNVVCRTFGFRECIYVDKAGLGQGSGNIWMDNMRCRGGESSFIKCPFNGWGVHNCGHHEDVGFRMWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D9Q4</accession>
    <name>A0ABY7D9Q4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MUC5B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_005921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF393">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFD" evidence="3">
        <location>
            <begin position="149"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ93450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="412" mass="45220" checksum="4BDBC70496BF96CE" modified="2025-10-08" version="1">MKSKRIYLHVHDCIRFCNRILICDGEGSAVDTIKLLHLYINFSTCVDARWACAAKTIPIPTTNICKPKQEYSSCISSCPMTCENMHDSISCNTTMCVEGCICKPGYVKEGNDCVLKADCPCYHGSKAYKEGENTCRSRMWVCEQKDCPAVCSAYGDSHYTTFDGRSYEFQGSCDYMFAKSSETSPVKFEITTENIPCGTTGVTCTKSISFSIGEQGTSHNNIKYLSTEFIYDPILQTVGTANFFRIQLVKGKQVIADADSPFTVREVGNFIIITTPQGITLEWDKGTRLYLKLSTQHKGQVVGLCGNFNGNQKDDFSTPQGGPSASKATSFADSWKILARRTRNAAPGLRSSVASCPVNCSRHAIMFVAYQEFIDRCVFDACACDTGGDCDCLCTAVAAYAHQCSMSGVTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D9X1</accession>
    <name>A0ABY7D9X1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IFI44-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_006923</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFI44 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241:SF32">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ94452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="460" mass="50853" checksum="BA6BEFDE687503D2" modified="2025-10-08" version="1">MCTILTESDFDQVESWIGTGPKTFNLLYSITRDGCDTSVFHQKCDNQGPTLTVLYNKEGSVYGGYTGLSLESGAGNRNDNSAFLYQLYYSGLNTPKKYSVKIGQAAICSAPHLGPLFGSNTAYDVLTFHSIVQKSSSGEYNLNGDMQTYFGRNYDTAGISSKEFNNGHIRVTELEVYAVKDVKRKTPALPTPWRKTAEFGTKMLGCLKEEVKGIQPPEGLDVPHFNILLLGPLGSGKSSFCNLVASLTPYTFGDTVSLQLYDTRGVAETDTLDLLQCNFILDGHVPDFYEMSPTHLLKCDDAEFRHQAALKNKIHCAVFVLDGLIVGDMSKSMLQKLLSYRDLLNRKGIPQAALITKIDKLCEQSAENISNTFLSPAVKDLVYNVADLLNLPRNSILPVKNYEEEMESDENINILALLAVRQILFFAEDYLENMKDKQSRSRGNANSGQAHSDVRGSDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DG47</accession>
    <name>A0ABY7DG47_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_028948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ96258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="157" mass="17905" checksum="B9CEAD90671FDE36" modified="2025-10-08" version="1">MEEAAKFNFSEAQAFCRQTGDELVTLDTYAKFNFVQYAIIHHSKDEQQQRNYWIGAHANLTLSGKVVGWESLRTWNFTAWGPGEPDVDPSQLCGVLNVLENYEWFDTRCDSPFHFICERDILVNGGFTTDMPHPTASSKPLTTPSTPSTSLRHHIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGN3</accession>
    <name>A0ABY7DGN3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_028274</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045779692" description="N-acetylgalactosaminide beta-1,3-galactosyltransferase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="13">
        <location>
            <begin position="116"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAQ95584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="311" mass="35568" checksum="D52C089D9EE540E1" modified="2025-10-08" version="1">MNTHGLRLLMTFLFGLSIGYMFNEFLSGKCDHIAEEENSYVSDILQKNGVLSEHHVAETSVVADLLREKVRVLCWVMTLPANHFTRAEHVKNTWGGLFMSTGREDALPTVVLPVEEGREHLWMKTKMAFKHVYEHFRDKADWFLKADDDTYVIVENLRYMLKDKDAMKPVYFGRHFKAGKGKGFMSGGAGYVLSKRALTQLYTSLSDPSKCELSTRGAEDVELGKCLEMAGVKPEHHLISGALQDNLWYWSLNKYPVVQGPGCCSDYAISFHYVNPNMMHVLEYMVYHLKPYGRNLITNVINCDEIHRTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DI01</accession>
    <name>A0ABY7DI01_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PBLD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_029022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhzF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF17">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ96332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="310" mass="33486" checksum="36EBF64CBEE05ADE" modified="2025-10-08" version="1">MAAELSIFTVDAFTAQPFTGNPAAVVLVPGSTYFATRRSTCYTCVAHGDIRIKNTGVEIIARDMMISNEIKVSMDLPDVLQQTIASEMNLSETVYIRTLPDGGDFKTGCRFGIRWFTPTNEVPLCGHATLASAAVLFFCQGNTNPTLTFESASGPLSARRTGSGITLDFPLNPVQPFTRAANIIKEICEPSHVQDVQYSPATKKLVLRLQDNLSRDYLESLSPDTRSLQASDVSGDVKGVIVTLKGTPEAADYDFLSRYFAPWNGIPEDPVTARQCSPRGGDLGVAIVGDRVELTGSACVVMRGHLLNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIA3</accession>
    <name>A0ABY7DIA3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RL1D1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="308" mass="34456" checksum="1289277437D17BD7" modified="2025-10-08" version="1" fragment="single">MIERKQVEKAVTALLTLIEQKDSGVVDIVDQPGKIEVQTLPNSLHYDTREVCLFVKDLDKKNREYELTVQHYQDLLHKKNISCISKALRTDYSMHSAKRSLAKAYDLYLADEAVFGLLPGQLGKIFFAKKRLVPMKVNLSAKALKSEIEDMVNNTRLVIQGSGSNSCLTVGHSRQGMSKIVDNIVSVVSQLGDKLPGGLNNVKNIYIKSANTKSLPVYFDMGGVENVDLPDIKEDKLTELTDEITTVEDARVKIRADGQKSPKGKRALERKDDGDNVAEMKKIKTVAEKKVKEKVNESVNRKTKKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKR9</accession>
    <name>A0ABY7DKR9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_029774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ97084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="350" mass="42508" checksum="517D9B24F2CBED1B" modified="2025-10-08" version="1" fragment="single">SLYHVVNHNQVVNHFHTVKHNHGVNHYQVVNHFHVVNHYQVVNHFHVVNHYQVVNHYCGVNHYQVVNHYHGVNHYQEVNHFHVVNHYQVVNHYHGVNHYQEVNHFHVVNHYQVVNHYHDNHSHGVSHYHVVSHYHGVKSYHVENHFHDNHYHGVNHYHVVSHYHRVKPYHVENLFHGLNHYQQVNHYQVVNHFHVVNHYHVVNHNQVVNHYHEVKLNHVVNHYQIINHYHVVNHCHILNHNYVQNHTQVVNHNHVVNHCHILNHNYVQNHTQVVNHNHVVRHIHLENQNHGVNHYRVENHNQVVNHFHVVYHNHVGNHCHIVNHYHIVNHGHVVIHYHTIWGSYNHKFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DL31</accession>
    <name>A0ABY7DL31_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="115"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="196" mass="21803" checksum="D8A027E5584272A2" modified="2025-10-08" version="1" fragment="single">KERGKGDVFKKTGPSKKWWRGFKQRHPELRLRRPDSLDRGRDTMWNRIFYDPEGDSQLHLIFNCDEAANLNKSAGQRVVVPSSQKHAHSVAAATNGHITVHCCVSAAGGTIPPIWFEKTFLKFAPSERPLLLIQDGAFSHVSCPLIKSAIASDVILLSLPTKTTHITQPLDVAVYRKMKIEAAGIMSHAKLIKSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DL73</accession>
    <name>A0ABY7DL73_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AT2L1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_029528</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF13">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ96838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="392" mass="43212" checksum="5FF5132C30D5698C" modified="2025-10-08" version="1">MVLAVGHCHKDVVEAGYHQMKKLNTNSRFLHDNIGRLAEKITATMPEELCVVYLCNSGAYHGHIMSCIDISPYKLKVQRDGVHTCPSNVYVAPCPDTYRGKFVDCDYPGEDLGKLYADEVRDICKVVHAKGRGVCGFIAESMQSCGGQIVFPPGYLQKVYSHVRAAGGVCIADEVQVGFGRVGSHFWAFQTQGVIPDIVTMGKPMGNGHPVSAVVTTKAISAAFKDCGMTYFNTFGGNPVSCAIALSVLDVIEREHLQKNALEVGNYLMARGSALMEKHEMIGNIRGFGLFVGFDLVRNRKTREPATEEAKFVVQRMKSDYKVLLSTDGPYDNVLKFKPPMCFTKQNVDDVIRDLDNLLGVIPQHKFEPSHRWTVVDASPLGSRVMLLKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DL80</accession>
    <name>A0ABY7DL80_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="12928" checksum="96143D8C4D09EA9D" modified="2025-10-08" version="1">MRNQSSEELYAAIITEGNEELVSCVLIADGGGNVGHTGATTVTRGQECLQNMNKGWDHSHIIHNICNIESRMNTLSRVKSYHAYRNKRNIPTRCFQCQEFGHIAAICKKVNFCEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DL94</accession>
    <name>A0ABY7DL94_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed primase/polymerase protein</fullName>
            <ecNumber evidence="6">2.7.7.102</ecNumber>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_030348</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:22509"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate.</text>
            <dbReference type="EC" id="2.7.7.102"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.102" evidence="6"/>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044917">
        <property type="entry name" value="PRIMPOL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31399">
        <property type="entry name" value="DNA-DIRECTED PRIMASE / POLYMERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31399:SF0">
        <property type="entry name" value="DNA-DIRECTED PRIMASE_POLYMERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="402"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ97658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="439" mass="50064" checksum="38095C4066BB26CA" modified="2025-10-08" version="1" fragment="single">MINFSGKCNETMEDMNSGTSLTTSSFYGAKNKRKWMGLQNSIETMEKQFKKEKIPKPFPSRILGPSVKWEIFFRQQDAFSYSRSKSKDLHVFAFESDSFEGNSGQRLYLATSYPVFWHYYSQMDDDKRHHYEVIPEGCVCKLYFDLEFDRTLNPAADGDAMVETFIQVICAGLSEEYSLIATRREVLDLDSSTEVKFSRHLIFQLQNAAFKDNIHAGRFVSHILSQVLLAVEQGDKDAALAQNMNNVENNQSDDVIDSNNENGNIPCLESKAEDVVKELTVDGLKDNMKEDNCMRNKLLKTVSLADLGSLFVQSKHGEMVLFCDTGEATIDGYSKSPYPEVDEYIISLITQDSGKGVIRHWTYFQEGELLVLIADLQRGVFYQKCHDPDCHMQNYKSPASYFDDLEEEGDNGSSDMDDEELLNSTLELEKHLQHRNPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DM21</accession>
    <name>A0ABY7DM21_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ97579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="230" mass="24427" checksum="DE4B3BECF26775A0" modified="2025-10-08" version="1">MQGWKRLLVKTKCTSLRKEQRSLNARFLDIEEETDAFISYSVVYDGLNGREAGVDSVVYDGLNGREAGVDSVVYDGLNEREAGVDSVVYDGLNGREAGVDSVVYDGLNGRETGVDSVVYDGLNGREAGVDSVVYDGLNEREAGVDSVVYDGLNGREAGVDSVVYDGLNGREAGVDSVVYDGLNGREAGVDTGVDSVVYDGLGREAGMDSDVYDGLGREAGVDSDVYDGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNB8</accession>
    <name>A0ABY7DNB8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SC5A9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_023560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819:SF195">
        <property type="entry name" value="SODIUM_GLUCOSE COTRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ99187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="428" mass="47951" checksum="BEAE1E0FA4DF5F02" modified="2025-10-08" version="1">MVEKLVWEDYLTIGIYFAVVLAVGIGSSCRPNRGSAAGYFLAGKNMHWIPAVYFLILLGWVFVPVYVACGAYTMPEYLKKRLGGRRIRLYSSVLSLVEYILHNISAEIYSGAIFMQALLGWNIYLCVIVILAVTAVYTIAALIDVGGWEGLMTKYPLAATNYTLANQSFYECGMPRDDAFHIWRSATTGDIPWPGALIGLTTLGLFTWCQDQVIVQRCLSAKNLGHAKAGSVLAAFLKLFGFLLFVIPGMISRINYTDDIACASPEKCFDFCGNKAGYSRLNAGSLTCSFNEFIDIHFQQRKLYSYVRYLQSQGGILWFYLQAVKSYLVVPWCMLFLLAFFWKRLTEQGAFWGLMVGLVVGLIRMGLDFAIRAPYCGSGETDERYTHVSNTRITNLKAKKIDKCFGHFTFIPYKSICQSTMQGATTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DP34</accession>
    <name>A0ABY7DP34_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="176" mass="19850" checksum="3FB5E17835EFC88A" modified="2025-10-08" version="1">MSIRTRLFEDSPVSDVTSGSPWDEIAAMLTPCQTVNESLDSGIGSSAELSIKLPSRRRLRSIRSGDVKRSLFSRKRPADSEVDDSPAVKKVRGEDIQTIEKDIIHAVERLETRRLRSIRSGDVKRSLFSRKRPADSEVDDSPAVKKVRGEDIQTIEKDIIHAVERLETCDLFFVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPQ1</accession>
    <name>A0ABY7DPQ1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S ribosomal protein L36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_023264</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ98891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="129" mass="15009" checksum="08A4D927C3B8196A" modified="2025-10-08" version="1" fragment="single">RSVFTSGSAEASRNSTSFSIRHLDMGLPKYELAIGLNKGHKTTKIAECSKKRQSRRKGTITKKNRFIRDLVREVTGFAPYERRVQELLRISKDKRALKFCKKRLGSHIRGKRKREEMQTMLQKMRKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQK5</accession>
    <name>A0ABY7DQK5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZIG8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF36">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="123"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="291" mass="32519" checksum="C4D83E694E7F7C67" modified="2025-10-08" version="1">MVMNCETRLLSSSTYQLPVYNDTPSNITVYRGARAILRCSVRNLGPKQVIWKKASSDFALTFGDMVFVDDPDISVVHVPHQEEYNLVISNVQPHDAGVYECQISTKEDLRKYVLLNVLDQTAPSSEAIKITGKSYVEKGDQIILTCNATGELYPPEDIDWFKDGSKIKPNQFKGISIAKFRIAETKTLHSQLEIDHSSMDDSGNYICRSSELAITDKSVIVLNGSAKRSRKKILYEDNDNNDPAAPMSSAACTISSLYRHGRLCTCALTFLCCVLIVSNICQRHWVFGSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSK9</accession>
    <name>A0ABY7DSK9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="333" mass="37798" checksum="2959723C23AFDD0F" modified="2025-10-08" version="1">MSQKTSTCVLFDGNKKFHSFGFDAEDNYSGLALDNKHHGYYFFKQFKMMLFDKMTLKRRFMLEDAMGKKMPAMDVFSACIRGTVDITVHEVQDNNSLRELFKANGGNWGGTYIEKAFRNMLAEIVGNDVMDNFQATNMMDFIDLLREFEVKKRNFNSTMSQKITFKVPIALNVDFKAKHGKDIKDHIATKSQYKENVSWVSDKLRLASETAKESKKFIDDDGDVLCSDMFDKHVEIGQPVEYGKSQVAESYCPTSKAATRMTFEVFASSERDPTFVTEPSCKKLGSLQVDIAGSGTNRSVTVEMSFSGTELHVQAHETRTPDRRTTAKFDFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DT71</accession>
    <name>A0ABY7DT71_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SVEP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_022523</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF4">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1671"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="228"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="394"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="472"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="561"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="641"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="727"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="785"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="895"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="1005"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="1155"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1219"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="1328"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="1409"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="1595"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1739"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1863"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1744"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1898"/>
            <end position="1907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1929"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1946"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1957"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="644"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="923"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1031"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1356"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1412"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1623"/>
            <end position="1650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ98150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1966" mass="206339" checksum="ACD2056BD70C6618" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTF3</accession>
    <name>A0ABY7DTF3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HRH4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_024264</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF195">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="56"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAQ99891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="379" mass="43366" checksum="DA750E96D52EFA67" modified="2025-10-08" version="1">MAAFRVTFVRCKMGVYNEPDNYYYGDNDDGVVPMTLGVQIPSAIGLALLIVISITGNALTVVAYLRDKHLNTVYDFYIFNLGVADLLLSCISLPFYTVYTLMEFTWPFGYTFCKIYLLIDFTLCFETIVLMLIISFDRLLMITLGPSYLTKVTLKAAIIQIAISWVLSFLVYGPAIIGWNHWVGYSIVEEMDCDAEFAYDRTFTTITAFVEFILPFVCLTVLNFLIFFKIRQRMKVFPSKTATFKTSVSVAVNDETRTDEALNEQMRKVDDKADSNHFNRQRKAARFLAMLVAAFLIFWAPYTITTVIISFCEKCVNISLYEFFNFVLWMKSAVNPFLYAYNSPRYRRHFWKFLSCNGKIPLFGLSKTVGGAQTTVTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUI3</accession>
    <name>A0ABY7DUI3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_024624</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010876">
        <property type="entry name" value="C1orf43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21425">
        <property type="entry name" value="NICE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21425:SF2">
        <property type="entry name" value="PROTEIN C1ORF43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07406">
        <property type="entry name" value="NICE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="124"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR00252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="208" mass="23705" checksum="29E521317E9DBADB" modified="2025-10-08" version="1">MKSEEEQSMRAEITRRLERVPEIKHEPKLLNPTIEQAAKSSNNHYYYRMKAVDAFTKFDECLRQDVPAACRHPKYSMRDYLTTIYPVYLSTAPPELINSLEQGIKMKNEANIEQMKQLPTVDTEVKLKSSHKGIGKTKTSIPYNHMTSDKHSSRGQTRYRTRANSSEQAGLLESAPSSQRSSIEGLVTAHDSSENVRLVEVNMNTMPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DV74</accession>
    <name>A0ABY7DV74_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">KCNC3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_008153</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003974">
        <property type="entry name" value="K_chnl_volt-dep_Kv3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01498">
        <property type="entry name" value="SHAWCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="BTB" evidence="9">
        <location>
            <begin position="190"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="280"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR01595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="318" mass="34964" checksum="2D84C5216188F2D4" modified="2025-10-08" version="1">MPVDCEYSLIDKQPRTKNSAVCRSPNLGSRSPSPGRSGGRRFFGSSEKSKLQRNRFGDSEYTPRTPDCFDRGSRNSETLSIVGHKHNGGLSPDGYTDNVLGYGGDRETTGVDNAGGNMALSAVMMSGGGGGNNGGGGMKQCNSHYSVSDLQHGDGTIWTLSNTSEIDLSRSWPGSQTPNKCNCDKIRSKETVIINVGGQVFETFRSTLKRLRSCKLASEQEMMRHYRQEKGDFFFDRDPYAFNIIINYLRYGNLHLPTNLCGPTLMREFEYWGIDEGDIERRKPNPLRSSNTTGSNPPHRRTSHRTGTARAAGAASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DW90</accession>
    <name>A0ABY7DW90_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038754">
        <property type="entry name" value="TSBP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14368">
        <property type="entry name" value="TESTIS-EXPRESSED BASIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14368:SF7">
        <property type="entry name" value="TESTIS-EXPRESSED BASIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="769" mass="82664" checksum="44731757BEC61F51" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWV3</accession>
    <name>A0ABY7DWV3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GSTT3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_007937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051369">
        <property type="entry name" value="GST_Theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43917">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43917:SF8">
        <property type="entry name" value="GH16740P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="16"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="104"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR01379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="238" mass="27748" checksum="2A615507A3557FB6" modified="2025-10-08" version="1">MLPMCDTRTLSVIRTMLVEFYYDLRSQPCRAVYLFLKATGIDFTPKVTDLLKGEQNQPELVKKNPYHKLPLIDDDGFILVESVAIMRYLAMKNNVADSWLPRNDVKQMARVDEFLNWHHLCVRKPCVRNKIVFGHFTKEPLDKERAKTLREEVKKFVTHIGDYYLKDRPFIAGDEISVADISAVCELAQLTGIKEESLYMENEVVGAWFERVKAKLQPHYDECMETFAAFKKKFEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXF3</accession>
    <name>A0ABY7DXF3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="21">GBRA4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MAR_023993</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">MELC-2E11</strain>
            <tissue evidence="21">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19007">
        <property type="entry name" value="LGIC_ECD_GABAR_GRD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001390">
        <property type="entry name" value="GABAAa_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01079">
        <property type="entry name" value="GABAARALPHA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="35"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="245"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="WAQ99620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="383" mass="44244" checksum="6277DB2DA0B5B31D" modified="2025-10-08" version="1" fragment="single">MDLQWHYLSLFYFLSGPVAWSERRYSEHENMSLQLDRLLLGYDRRLRPGFGEEPLVIKTDILVRSMGPVNERTMDYSMDCYFRQLWVDKRLALNVSMPNISLNIKVMDRLWYPDTVFLNGGKSFVHMIPMPNKFFRINKDGTVFYSQRLTITATCRMRLEKYPLDSQNCHLYVGSFAYSIDDVIYEWRFGAQKSVEIAAGMTLSQFDLLQTPCFNLTSTIRGAPHSVLAVHFYLRRHMGFFVINVYVPCLLLVVLSWVSFWINREATSDRIALGTMTVLTMTFIGLDNRNDLPRVSYSTALDIYVAICFVFVLATIIQFAAVHYFTKFGCGEGPQLVKYIAKEVELEEILEDQVGHGVMVLVIYASVVAQKAVLPRKRCYMCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYK7</accession>
    <name>A0ABY7DYK7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_009383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR02825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="12741" checksum="3B891A6DDF9703D3" modified="2025-10-08" version="1" fragment="single">VALWSSFAFNGIQTSFAASSNEELINTAYFILQAHSCIYNSLKNIHQKGQLGIDIQGSWFVAQSHSLSKTDPSTEKALALDVDLFLQPLIGRDIAKEYFGLNVPHFSPEQIINVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E037</accession>
    <name>A0ABY7E037_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046840868" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="13961" checksum="22B20C3C05495EB5" modified="2025-10-08" version="1">MELSDLLVTVLILQISLCTGISVSTNGGMDRLIQLQLLQYTQGSTLVDGLVLAGTIVEGGPVYGRDRKILGGQSVHPGLAFVDFGFQLDKCPPRTFGYQCKSWVPVECEVNRHLVYRGKLCTCKVNVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1M3</accession>
    <name>A0ABY7E1M3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR03903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="87" mass="8358" checksum="D7087E84A39F32FD" modified="2025-10-08" version="1">MASFGCMAIIKGMDSIGIMASFGIASIRGISSFGGMASIGGMPSIGGMASIRGIASIADMASIGGMASMGCMASMGCMASISGMASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1R1</accession>
    <name>A0ABY7E1R1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="404" mass="44765" checksum="119F96DF45F97991" modified="2025-10-08" version="1">MDKASRALRRSGAKLMSLGTAHGALNILLADLKEVKMGAKTFMEAQHQAAQDMMKWAVTEENRAVKDVISNIADLYLMWTDVQKNFMGYLKEYRQVFEMVLEGEKHVAQARDNHRASSSELRLLESRVEMAIQSKNLADVEVSERIRENEAVKLIRLKEGLLKMSDSYIEMAYKANIIFGAQKNVALQLPDVHGQELEHIQYSVTADPPPPYTPPEPSQPAGGRPDSPEQGRGTQGLDRRGSRDTPSRPCHPPAKPRHSFPQESMTNRPSSGEIRTANSTSDQDLPTYSSSQNNSNQQPVLMHSTSEVIVRSSSGPNIANSDNEDVTQRGRTVSDTIVHTNTVRIVRESESPRASGRSSPVVGERREAIEHEGPDTPGAKLYPDIGATNDDQPDKTRPVPTPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1Y4</accession>
    <name>A0ABY7E1Y4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRAM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR04012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.50">
        <property type="entry name" value="Insect antifreeze protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="253" mass="26712" checksum="4DC0BD339F9D3F23" modified="2025-10-08" version="1">MLKKAGGCIVTSLCRNAERCIITNPCINAGPCIIDSPCRNVGRCIITSQCRNVGRCIITSQCRNVGRCIITSPCRNAGPCIITSQFRNAGPCIITSQCGNVGRCIITSQCRNGEPCIITSQCINAGPCIIDSPCINAGPCIITSQCINAGRCIITSPCKNAGPCIITSQCRNAGSCIITGPCRNARRCIITSPCRNAGPCIITSQCRNAGTRIIDSTCRNARRCIITSPCRHAGRCIITGHVEMLDGVSSPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4K3</accession>
    <name>A0ABY7E4K3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_020139</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9 10">Cytoplasmic vesicle</location>
            <location evidence="9 10">COPI-coated vesicle membrane</location>
            <topology evidence="9 10">Peripheral membrane protein</topology>
            <orientation evidence="9 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9 10">Golgi apparatus membrane</location>
            <topology evidence="9 10">Peripheral membrane protein</topology>
            <orientation evidence="9 10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4 9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="12">
        <location>
            <begin position="249"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="167"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR04770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="426" mass="47856" checksum="4F1CACE4D502CE0F" modified="2025-10-08" version="1" fragment="single">IALLDVAEKCRRIINEFCRIQELFEQSLQNGTAGGSSVQQRRERIEGLLAAFPKLMNTGKQHTFVETESVRYVYQPLEKLYMLLITTKASNILEDLETLRLFARVIPEYCRNLEESDIVDQAFQLIFAFDEIVALGYRENVNLAQIRTFTEMDSHEEKVFMAVRQTQEKEAKDQMRKKAKELARQRQDAERSGRAAGLGSGGFGSSSFNRGSDTTSIIDTTPMEPVKPAYNPPSRPAGKGKALNLKSRKQDVDSFVGQLQSEGETGRDGGLQALELHGIIKLKVNDEKLARSVLHTHPNIDKKMFASQSVIGLKNPEKPFPIGQDIGVLKWRFTTQDESFMPLSINCWPNESGSGCDVNIEYELEQEDLELNDVQITIPIPSGVGAPVVGDCDGDYTYDSRKNQLHWTLPVIDASNKSGRFHKKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E620</accession>
    <name>A0ABY7E620_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="122" mass="13874" checksum="BF38409968540F95" modified="2025-10-08" version="1">MRTLLISYREKTSSLNSNLNTSIIIKFKHNLVFQNMKSVGYFVVWTANDLHVEANMFDNELWDKICASAKDIMLPTANSLPVGILHSVENTTAGQNIQPLKKCSNKQDSTEEVYCYCCQVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E773</accession>
    <name>A0ABY7E773_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_021084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF164">
        <property type="entry name" value="MAM DOMAIN-CONTAINING GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="71"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR05715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="166" mass="18242" checksum="6B445D15758C1396" modified="2025-10-08" version="1">MGEYKCTATHSVYTTYNDTKTYSVTVILNQYQQERNQALTFIRGCSLRICDGDCKFACAPFPDLKPKAHGPDSISIFPLTSSYTRTEGDIQEDITCSTVCHPECAYTWSKVGTSGVVRNNSILNLDQLTRQEAGSYICSATNPISSATRNGSTVVVEVILPSHPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7V1</accession>
    <name>A0ABY7E7V1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="306" mass="35427" checksum="F8E1421408BF06E1" modified="2025-10-08" version="1">MHFVKSFDCKTLKFVLLNVCGIISKLCFPDFDKFMLKCDIFCLTETKLDDFDNVDVSVFKFQGVHRIGGLKKFGGIGFFVKDYLWKYVKFVNCNNENCLWFEIDSKLSNEKCMFGVIYIPPESFVYSFVDIFDKLESDIIDFKAEGYSICLLGDFNARTVHLSDFVSVDDFDYQTQCEFRNNLEVLGFVTDRHSEDSVCNKYGYRFSKRCKPLDVHILNLLMFTLLGSDVFIGKTTCKNVSVIDYLVFSPCLFPKIDKFDILPFDPLLSDVHDPISFDFICNSQVHIGHSCSNVKTENNRAPIYMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E829</accession>
    <name>A0ABY7E829_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="117" mass="13404" checksum="1D1834BC7BCA9A51" modified="2025-10-08" version="1">MRSEKHFRVSQRERVVPDCPVRMCLVCTGHTLRNRLDGISLPAKEGQHRKIIYATDWALCSVKVMQAKGTYDGFMKSICKAAQFDQQYTAHFLRVTAIQTMNEAGFEARHIMFISGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8Z4</accession>
    <name>A0ABY7E8Z4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-ACP thioesterase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049427">
        <property type="entry name" value="Acyl-ACP_TE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34487">
        <property type="entry name" value="ACYL-ACP THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34487:SF1">
        <property type="entry name" value="ACYL-ACP THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20791">
        <property type="entry name" value="Acyl-ACP_TE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-ACP thioesterase-like C-terminal" evidence="1">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="301" mass="34500" checksum="B1F10FE8504BE1E5" modified="2025-10-08" version="1">MDSKFSGLPDLRTIQPGRLIKYRISDDGFAAELLLPGLTYTDFDQKIGGKMNLWSLAKLFESIRYVVLPNGFCHYNRLKDVGHSIFNAETSYHLSDKGNKLKAQTHWGTNYLMHAHLKVFYAGTSAFSFEIIVREHETGDFLAKALLTFVYVDFKTRRPATFPDWFNKLKENQHFGPPSPRLARPSIPLDAYKFEIQAAFSDIDFNGHVNNSIYIKWCTDAGTEAALKGHYSGFSENIGKYPMDVFEIKYLGEGVVSDVFEILTWQDQENPFVLHFVFTKNEKVSVVVRFQYKSLQFSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E937</accession>
    <name>A0ABY7E937_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_020869</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="137"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR05500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="865" mass="99444" checksum="58E087FCA932F5FE" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAE6</accession>
    <name>A0ABY7EAE6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HMCN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_021141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF164">
        <property type="entry name" value="MAM DOMAIN-CONTAINING GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="282"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="378"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="535"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="619"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR05772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="642" mass="70701" checksum="79E58805073D9E29" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAR0</accession>
    <name>A0ABY7EAR0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039684">
        <property type="entry name" value="FANCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15254:SF2">
        <property type="entry name" value="FANCONI ANEMIA GROUP G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15254">
        <property type="entry name" value="FANCONI ANEMIA GROUP G PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="410" mass="45867" checksum="8D3EE245079FE09F" modified="2025-10-08" version="1">MSCLLDLFDNGQFAAASDQLTNITGHTTDLTTQLATENNAAVLAYIQLKAQRTSSDADLFKWKFENCLQNCAVCRVFHPRKTKLNYDCDEKSACVSLIRQCLKAIGVASACGYMPVCCLLARCVWLWCIQETRINNHTEAEQLLHTLADAINKTDFLNVHRAEVTGDYPVLTFPLYADHIQLPVTPGLEGPLSSVLWVVSLSGNTRYDQVVSVLDTVKDQHLAPSVKFLSGFASYKLGQYTEGISTLMEIVRSQPPATPRLRARVHFLIGLCFTKLTCPVAVFQDKRPLGLAMFREALCADFSFLRPLYTTALQYRSFGDNDMELECLNLLTMMRDSPGLPVTSGVDVLSLVDFEDEDITYPTALYTLASRALKLHKFDVAAEKYTILLQHLRTGTVQVSMLALYRRNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBU2</accession>
    <name>A0ABY7EBU2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BGH3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="15"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="169"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="306"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="448"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="589"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="745"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="945" mass="105628" checksum="75B46294DF571FEE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EC08</accession>
    <name>A0ABY7EC08_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Novel acetylcholine receptor chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_017521</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Peroxisome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DoxX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040399">
        <property type="entry name" value="TMEM35A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13163:SF0">
        <property type="entry name" value="NOVEL ACETYLCHOLINE RECEPTOR CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13163">
        <property type="entry name" value="SPINAL CORD EXPRESSION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="139"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR07563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="178" mass="20263" checksum="C2ACDB3672A67C62" modified="2025-10-08" version="1">MASFVLKVLAITLGVFFILIGLLKLSPAISSELYKEMRKQYIRMAKVFPLVAFTGWKPNAHIYRKIIASIEVTCGAVLIIIPGPLKTIANIMMILVMVNDVVAHAQIKHGYQRMSLPIVFILLLSCRLLIYYQEIRREREGKKSKQENVGQENSQEQTVGNSEQREETMPQESKKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ED46</accession>
    <name>A0ABY7ED46_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="63" mass="7110" checksum="C00A35823B4828DF" modified="2025-10-08" version="1">MTGVDQSLDHTKWMVTIANQPHGSAHFEMCLSTAFKQDHGRRYKYALLICVHTSLAVGKFISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDR7</accession>
    <name>A0ABY7EDR7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_017040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050260">
        <property type="entry name" value="FAD-bd_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429:SF2">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="7">
        <location>
            <begin position="5"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="7">
        <location>
            <begin position="279"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-rubredoxin oxidoreductase C-terminal" evidence="8">
        <location>
            <begin position="373"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR07082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="460" mass="51232" checksum="D8022FE79CE4CD2E" modified="2025-10-08" version="1">MKKNKFLVIGGGIAGVTCAEQLSSLCPTEEVALITASKLIKAVKNYQKVSRTLEQFDVEERPMIAMETDFPNVQVIHNKLTNLDTDKQVAMLADGGEIQYEMVCICTGARPRMIAANNPFVLGIRDTESVQTFQKRLHNARRIVVIGNGGIATELVWEVQGCEVLWAVKDRHISTTFVDPGAAQFFLPHLNKEKPDTSHEPIKRHKYAEQGEGDPVSADGGAALGPDWTADLQMRGITKTGHAVHVDYEVEVRSVMSPEEFRISGKPTTQPPGFSTEQGVVPNVQLFLQNNFTMSNEGGIQVNDQMETNVPGVFAAGDVCTASWDWAPHWHQMRLWSQARQMGAYAARCMAARDQGDQVHLDFCFEMFAHVTNFFNYKVILLGKFNGQGLGNDYEILLRVTKGVEYVKVVLHDNRMAGALLVGDTDLEETFENLILNQTDLSPFKDHLLDPDIDIDDFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEP5</accession>
    <name>A0ABY7EEP5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ZC12C-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_018446</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd18729">
        <property type="entry name" value="PIN_Zc3h12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040546">
        <property type="entry name" value="Rege-1_UBA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051101">
        <property type="entry name" value="ZC3H12/N4BP1_RNase_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876:SF35">
        <property type="entry name" value="LD08718P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876">
        <property type="entry name" value="N4BP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18039">
        <property type="entry name" value="UBA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="422"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="492"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="791"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="838"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR08488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="974" mass="110247" checksum="2186D16997DD5A53" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EG14</accession>
    <name>A0ABY7EG14_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHST3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13469">
        <property type="entry name" value="Sulfotransfer_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="419" mass="47705" checksum="33900D06DEC01F21" modified="2025-10-08" version="1">MSSYASSTQQFTVSSDQTRDAFTRSPFSRERLRSPQQKNIQSRGALNIITYYGNGAEKNKTEHSTSGEENMEAGSSGTIQIISNKSIIVINAYLRTGSTFTASLFETYPGVFYIFEPLHDIEKGFRAAEAAKTDVYLQYVDSSRKVTISKRSSVYLEEVCSWLSCRLQDLSKTSLNEQFLSQYKTKMKPFQTCMRRAKISLNGLNYGSAITSCLKKPIQDCQSASFVVLKFIRMRIGELASLLPYFPNMKIVHLIRDPRGMFNSRNHVGLSKVQRNSSDKDAVHGFCRLLEEDLRHSKELSISHPDKIFVLQYEDIAEHPYEWAKRLYKFAGMEYTNSTEDFVRRSTSATKDTGNMQTQRKNSTATSVKWGMQLSAPTAMYIYNTCRKSMDILGYLPLTTNNLRIMSVPSRHRINVTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EH54</accession>
    <name>A0ABY7EH54_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045779710" evidence="1">
        <location>
            <begin position="21"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="186" mass="21356" checksum="992B7DECE6CFBD5A" modified="2025-10-08" version="1">MDNICVVVLILLYNIKDVGATCGHLTYQEPAIQGRNVTFVFRPNTFKKNNNVTVRYDKTSIIYRNFPFDINDEVYYIHLDTTVDDLNNSYIFVKYGNCFTDWRKLTLMITREDSSTLSEEVNGTDVVKPRTVMSNTEGAVTKSKEKTTGALIYADLDIELLEAARKARKEQPQSAPTEYADIRYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHK9</accession>
    <name>A0ABY7EHK9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DIAP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_018244</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="520"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="350"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR08286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="567" mass="65285" checksum="DED98B68D6244ACA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EK14</accession>
    <name>A0ABY7EK14_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_034581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR09505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="44822" checksum="98CEF907996BD326" modified="2025-10-08" version="1" fragment="single">MGVDIQTYRARIGTNKFAFGSDVVTSRISVNFSLFLKSTTVSLFLVVMCLVLRSGAFEFSLIDAVDIANETKAEQNLESQLPSIDAVRYIPVILGPLWNCLVLKQRVAGLTGAVLFIGLLLLKGGIEPNPGPKPEFPMVIGLTDKIKLTVKCGKLHKVRNACLLVDYGFVLQNQEVLRVPFPVWDEYKPYSAINVETFGNNLKKALVQGFTQCEESPFSTVAFSPIVAGNSCQELSEVYIGFGILEFRKETKGTLREIQIVGEDEKILFDIHHCLAYMVQSNTQPPWFDISIFITTDVAIAEEANVKLTGRARHSSISAEVKAVFEELSLTERLRQKITLNEALAIDISKSKSPKSDRGLSETPWALLHELLHGNWEGRDNVPDTQQDDMGDWLEENSEHGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKT4</accession>
    <name>A0ABY7EKT4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TAF5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_034663</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR09587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="95" mass="10279" checksum="FFFDCEC6AF5DD06C" modified="2025-10-08" version="1" fragment="single">MLAQMRDHTNTVYSLCFSRCGSVLASGGLDNTVKLWDVTKVIKETDKDMEASIPSSLSVNESPNLLIGSFATKATPVLNIHFTRKNLLLAAGPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPF5</accession>
    <name>A0ABY7EPF5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GEM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_026048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF6">
        <property type="entry name" value="RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR11868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="410" mass="45855" checksum="C89FA3DBCD96AC12" modified="2025-10-08" version="1">MTKKAMNADKNERKHSVPKIRHEVSNDVKTDHEERTVADKNQRKIQILASEQGSHSSSILTPTAHHGRSSSFRSRPRPKLLNVDGDRPRRSSLPSPSANLLSVSFGNIPKHKETSDEQPLQRVRSFKTTSKGGIVNRGDSFKRSSNSINSTGSAMYSEHGGARSHNNSRQRINSTQSRDSDTADSTGSSMDTVIHKVAMLGDKGVGITSLTNQFMTSEFVAFETENDDDETDRHVTVLLNSEEKTLNIVDRPINLQEMSSQSFDAFAVVYSITDRASYQAAVDILYLIQHQLAIQDKPTVLIANKIDLVRKRKVTREEGRSVAKQYTCKYCETSAALNHHVDELLVGILSQIRLYKTPGLQMDPPSFDARPSQNKVAKCSMPGPKRLLNFIFRKKTMQPSCHECENLFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQA4</accession>
    <name>A0ABY7EQA4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="209" mass="23936" checksum="EAFBB29D824FFD81" modified="2025-10-08" version="1">MIKNYLDDMCDDYVDMGGSGLESIRLELTKHLVRFEGRMCWQTVLKKSYASTGEYVHFRFISNEKDPSEGFKILVTAFRDGIAIACVLTFIIIVTIIACCCCFRGRWRNTGNSKQSVYETSDIYVTPTPEDLYSELQYHKAASLPRSLPPPPLPTIQVDSVPPYTEQVQTVHAYEPYHVKMIGPEMTHERHVWITAPPETTRVSRYSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQG5</accession>
    <name>A0ABY7EQG5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ARA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_026412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/IRO homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211">
        <property type="entry name" value="IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211:SF40">
        <property type="entry name" value="MIRROR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="125"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="127"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="215"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR12232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="468" mass="51014" checksum="16BD32C00EA5D49B" modified="2025-10-08" version="1">MSSSGTVTSSRACCENGRPIMTDPHTGQTICSCQYGTALLNYSRVQALPESVYGASAAAYAAGAAQGYVPLGAEGSAFYSPLANPAAFDMKEGSEAWRALAAQGGCFPYDPNMALYPYGAGYGGLDLNARRKNATRETTNTLKAWLYEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWSPRNRSEDDVSGDEDMEAKINGIESDSSHVNASDNHERSSTSDREAFERIISVDDDDDESHDGIDDLELTNPKSLDLSSARSPDRLHDDKSDDERATARSRNSDGDDEDDEGKDNKSKNSNNNNFKSDSTHSSSEQPTRPKIWSVMDVLGNTENSSASKSSSPQNSPPAVVCSRQTSAPAFLNAHTSHPFRPGQYPVGLNGYPFSFSHTTLSYPYSLSASTAAKSEMSMSHLAAIRASEQAFKEGLVEKAARMQTGLFSPARELDGLRVRSKVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERE4</accession>
    <name>A0ABY7ERE4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="63" mass="7121" checksum="74C3CA101039D235" modified="2025-10-08" version="1">MANISLSVTFLVTFKKRQALGHYGSCFIKKNICSRLVSSFHFGHGLNSSSYKMEKLMNTFNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERV1</accession>
    <name>A0ABY7ERV1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CENPT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_026868</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-T/CNN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd22920">
        <property type="entry name" value="HFD_CENP-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028255">
        <property type="entry name" value="CENP-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46904">
        <property type="entry name" value="CENTROMERE PROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46904:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="7">
        <location>
            <begin position="651"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR12688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="754" mass="85104" checksum="4A428497EC830052" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESE0</accession>
    <name>A0ABY7ESE0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="87" mass="9316" checksum="545FBE529909A64B" modified="2025-10-08" version="1">MMKPIQPTGDAGEDEAEAVGALQGGVAYVEDRHLIVNQTSLIKDLSHIRKITNLTKGVVRMAKDGHALGMFEEQAVDKTNQGLGKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESF2</accession>
    <name>A0ABY7ESF2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GRAM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF116">
        <property type="entry name" value="FI16631P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="128" mass="13651" checksum="2D3792A881513AA5" modified="2025-10-08" version="1" fragment="single">MEATPGEFPHQVTLLNNGYHSCGGSVIANDWVLTAAHCVDGQALSSLAVVVDLHDFSNPGSSYIWFDIAQIIMHNSYNKGPGGFPNDMALLRLSRSTQPDITKNIIELAPGGTSFAGERCTISGWGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ET42</accession>
    <name>A0ABY7ET42_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_026066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR11886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="546" mass="61124" checksum="DD422DBBEB7B57E2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETW8</accession>
    <name>A0ABY7ETW8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_035692</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the exonuclease superfamily. TREX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd06127">
        <property type="entry name" value="DEDDh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057617">
        <property type="entry name" value="PML_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040393">
        <property type="entry name" value="TREX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058:SF19">
        <property type="entry name" value="LD40940P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058">
        <property type="entry name" value="THREE PRIME REPAIR EXONUCLEASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25244">
        <property type="entry name" value="PML_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="324"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="PML C-terminal" evidence="10">
        <location>
            <begin position="459"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR10616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="58672" checksum="F4CE45334C21A0DE" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EV20</accession>
    <name>A0ABY7EV20_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HOIL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_026563</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd01799">
        <property type="entry name" value="Ubl_HOIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF13">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="449"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="9">
        <location>
            <begin position="672"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="726"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="726"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR12383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="799" mass="89800" checksum="242BBAD8B05DD7E9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVK7</accession>
    <name>A0ABY7EVK7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CATR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_004073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR13968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="228" mass="25334" checksum="44F95A0386B7C098" modified="2025-10-08" version="1">MPKKKGKGKKGKKGKKKSGKKSSDSSPGPVDPMAPSYVPPPPKPGEQLVKLLTSHPVDEKEIHGVKVSTRILDNLTPQEIRDLRVVFELFDTNDDGFLSPPELRRAMKALGFKVKIEEAKQLANDGSLKGLGMLDFNEFLETACLDAKVKFKKQELQEMIEEADTNGDGLVDRDEFISIIASSFVRFFREYLGVGRALSELALPIARSQIYAEKQNAVQPNTKTELYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVL9</accession>
    <name>A0ABY7EVL9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_027472</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR13292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="471" mass="52578" checksum="ED03488D83AF2D17" modified="2025-10-08" version="1">MENFKPYDHFATDALHAGQEPEKWKSMAVVPPISMSTTFKQFGPGDHTGYEYSRSGNPTRNCLEECLAKLENAKHGMVFASGLAATNTMTFLLKHGDHIIGMDDLYGGTNRMFRQCTSRMGIDISMVDCTNLSNVEAAIKPNTKMVWIETPTNPTMRIVDIAGVVEIVRKKATKDCFVVVDNTFMSSYFQRPLDLGADIVFHSLTKYMNGHSDTVMGCACTNSDDLHEKLRFLQNAIGPVPSPFDSFLVNRGLKTLHIRMKEHMKNGLAVANFLEADPRVEKVIHPGLKSHPQYELAKKQMIGYSGMVSFYIKGGLDQASTFLKNLKVFTLAESLGGFESLAELPSIMTHASVPPEDRVKLGISDNLIRLSVGIEDEQDLVKDVEQALKAACYISVNIKYLIDWVKYLVIGGYEWFASVVSVEVNGGFAISFMLKDLKCTYRKCYDVEIDKKSFIYTSILTSDVTIFLNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2S7</accession>
    <name>A0ABY7F2S7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_005231</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="61"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR15126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="141" mass="16135" checksum="DA8EA64ECB0230A1" modified="2025-10-08" version="1">MSDDSHHTVLHDNGLMDEVVFLDVRGNLLSGVGVKVREGMTAHERPDNTFKTGKLMEEAGKKMIGEYDFCNFCKFSVKDGITDYWGYVRKIMEVEVKTLDETDDGFTMCELTIVWRAFLWHQIRSIFSVLVLVGKGKESVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2V0</accession>
    <name>A0ABY7F2V0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PRDM1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_031107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR16513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="95" mass="10739" checksum="32518F3A3142AF76" modified="2025-10-08" version="1">MLMLIHRDSESAALEVQPGSTLAELAQLSGSGRQCGVCGRQFSTRQNLERHLILHTGQRPFKCETCGRRFTQVSHLKSHKLVHMRRVIAGMEDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3T8</accession>
    <name>A0ABY7F3T8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LAR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_031429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="740"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR16835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="942" mass="104597" checksum="B8DF1B1F9AE7CE91" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F465</accession>
    <name>A0ABY7F465_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_031006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR16412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="104" mass="11728" checksum="7488EA8939B33BD3" modified="2025-10-08" version="1" fragment="single">MSEVSRAGCRDSLRIMSGQQGFTLQPTKLGYGTSTRRRKPIPEYGKPRGPLPMLLKHQVPDGQTVAASFYSKRFKSRRRTLILLIQITFCGIRALAVPFLLPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5G9</accession>
    <name>A0ABY7F5G9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPNA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052079">
        <property type="entry name" value="E3_ligase/Copine_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45751">
        <property type="entry name" value="COPINE FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45751:SF11">
        <property type="entry name" value="COPINE FAMILY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copine C-terminal" evidence="1">
        <location>
            <begin position="71"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Copine C-terminal" evidence="1">
        <location>
            <begin position="162"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="217" mass="24774" checksum="EF3FFB060827E64A" modified="2025-10-08" version="1">MRLNLDTNHCRLDLDSMASRKFRAYADRFSTLTEVAEAIREEGLGKCGLIFGIDYTMSNKVQGEKTFHGKSLHEICEDRLNPYQEVIKILGQTLEYFDDDNYIPSYGFGDITTKDQGIFALKKGEVLDAYNRITPSVKLHRPTNFAPLIYKAISIVQATKKFDDRLPTRNFDNFQFVDFAEVMSSSSHPAAAFALACLMEIPDQYRAIRQLGYLEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F621</accession>
    <name>A0ABY7F621_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">inx</name>
        <name evidence="10" type="ORF">MAR_004861</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR14756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="351" mass="40441" checksum="9A96580A241574E9" modified="2025-10-08" version="1" fragment="single">FIFLDKWTTWTRLTGNADDDWADRLNHIVTVVLLIAFSVFVNTYFIPMEENVPKGNNREHELTYYQYVPMILLFSALLVVWRAFSGFSGVDIRKLVEMTAEAHYVDDAKRDAKIEEIVCTIDRWLEGNRQYHWNCLVRMRQKLSRLCFCLNRREGTYLTGLYLISKLMFCVNVICQFYILDAFLGGFYSYWGIEAIRTLAVEHQLKESRRFPRVSLCSFSVRGIQQKCSVSYPSIYSMRRSSCFCGSGSYLLPFQSEQTSCPGYGTSSSAEIGSPSLQTTTDKSLCTKFGNYLRDDGIFLLQLLARNSNPLHVTDVINGLWDRFLEKPISKKVLADLRPPNLQNNNKGDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F6K8</accession>
    <name>A0ABY7F6K8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FIBA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR17818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="183" mass="20630" checksum="32FDE68F3AB88F08" modified="2025-10-08" version="1">MSKYHKPKDCDEVKEMSQNKATTGIYRIRPDGSSNFLVRCDMETLGGGWTVIQRRVSASDFFQDWTTYQIGFGSVDTNYWLGLQQIHNISTQGQYELLVFELGDVKSKYELTVDGYEGTAGDSLSHHSGQPFSTRDKDSDSYGGNCAEIYFGLREGPHLGDIQHILQVLDVSRDEDKKKATII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F6T7</accession>
    <name>A0ABY7F6T7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_031115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR16521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="247" mass="28317" checksum="B5BD47AAA713DE89" modified="2025-10-08" version="1">MDELKPGEHFDTNAEDHTPDRPADPKDKFRKVSTEQPKTKKLRNTAGNSEHLGNGVNSKPSITDASNNKSQEQNTDDVNHNLNKVATKNFGDFVAAKDRSYYLKQFKKPKCDQYWPDHGITKQYSEINVTCLTEDMYADFVMRTFSVHVDEEDRTVQHLHFTSWPDNGVPDDVTSLVDFRHRVLQTQSPLDGPPIVHCRQGMDQYAFLHHAIVHTLTLDSKPVPTEGFEAFMSDSENEQRQIKQFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F822</accession>
    <name>A0ABY7F822_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA polymerase II subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_000166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="215"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR18328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="345" mass="38707" checksum="5D6F6302136C8BA6" modified="2025-10-08" version="1">MDRQAVLKCKITATWINNGISFNVREASSDNVFTVIDAFSVPRFTYQKDRKKFIPNSTLGIPPPCLHGSANDKASLYRERYTILHQRTLRHDLFTPPALGSTPSESKKFQLKPIEYLLGTTAKLGDVIVLGMLTQLKEGKWYLEDPTGVCQIDLTKAKFHTGLFTENCFVLAEGWYEDDMFHVNAFGFPPPEPAKTTRSFFGNVNFFGGPSSTSVKASNCFTKLAELLSDYPELVRGSKFVFVPGPQDPGPSTILPRPAIPNSVIEEFKKKVPSSIFTSNPCRIQYCTQEIVVFREDIVTKMCRNCVKFPEDGDVPTHGSFPRTDYSFKVYLPATKQIEDSKIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8I6</accession>
    <name>A0ABY7F8I6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">XRCC5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_031683</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ku80 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="13">
        <location>
            <begin position="257"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="577"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="604"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR17089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="616" mass="68195" checksum="CE47FEB2E62BFCC5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8P4</accession>
    <name>A0ABY7F8P4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Y736-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_032323</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42948">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42948:SF1">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR17729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="505" mass="57012" checksum="AAC8A58D493079A5" modified="2025-10-08" version="1">MVPMEAMETKMAEAHISRRHLGSCSRAWAVSWARATSGGGLVFLITWMLFLFLWSSPLLIIEYGTGRYSKKAVLGSFRKFLGDNHMWCGAWVTMVTFCISCFYSVVLGWCFYYFIYYIGHSLPTTEEQARRTFQDYAEGVKTIEKVSLVLVPVLLLVVMFNFVWSLTREFGDKGIEFLFTPHWKSFLEPRVWVDAISQNAFDTGAGMGIMIPYSAYMTRKNGIVKYGHLVPAVNNLVSLLCGITIFSTVFSTLMLSRPTYTQADIVNIMKDSGPASTGLTFIWMPVLFETVGDFGRVLAIMFFLSLSFAGVTSLMSNFELATKTLEDFGLPRRFGMPLTILITFLVGLPSALDIDILTNQDFVWGFALVINGGMLWYMVLRFGVRKFRQKVVNEVIVPIEAIAIVAWWAIDLITNDSGDGENWYAFGRETLVMTLTQWFGLLLLVILVNVIYIIIRDRKQEKVSYYGKETDPLILPSSGNASSRDLDHSLTVSRDLTGSLKELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9Z5</accession>
    <name>A0ABY7F9Z5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain collagen C4-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF18">
        <property type="entry name" value="SHORT-CHAIN COLLAGEN C4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045465682" description="Short-chain collagen C4-like" evidence="2">
        <location>
            <begin position="26"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR17513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31445" checksum="98B8991A5306B523" modified="2025-10-08" version="1">MDLRQAVFVLLILQGLASRTLYCLASQTCKDNDIRTAVLLNRETQTNLREMKLDMEQQLQNQGQELTQMQEQLNSLIDIADTVKDLKKEIETLKTAVVETTVNVTSSSIYTRWGRRSCPDDTELVYEGFAGGGDYHDYGASSNYICLPKDPIFVGEGSNTGYANYIYGAEYETNGTTILSTLNDHDVPCAVCRVAGRSIVMIPARNVCYSGWQKEYSGYLMSSYYGHLGNKELVCMDGSPEAAEGSDSRNQNGALFYIAEIKCGSLKCPPYLANEVITCVVCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FB80</accession>
    <name>A0ABY7FB80_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_001261</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000956">
        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="369"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="275"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="775"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="951"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR19423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1018" mass="116942" checksum="266EB4F0C2D153DA" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDE3</accession>
    <name>A0ABY7FDE3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ARF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_001232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00878">
        <property type="entry name" value="Arf_Arl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR19394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="188" mass="20864" checksum="A27BF3E2148785A6" modified="2025-10-08" version="1">MGGLASKLSKVFSPFKNCPARIAMIGLDGAGKTTILYRFKLNETISTIPTIGFNVETLTPTKGLELTVWDMGGQERMRPLWRMYLRGTDGVMFVVDSGDRERIPEAKEELLRLLDTQEMKNVPLVVIANKQDLPGAVDAKDMTKRLQLPQMSARPWVIHSACATTGEGICESMESLAKMVKEYKAKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FET3</accession>
    <name>A0ABY7FET3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BAT36-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_001727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF17">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="69"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="390" mass="44929" checksum="7FF7CB73552E9E15" modified="2025-10-08" version="1">MFKKMATFVNEVDINYAIESDPEVDIKLPDSIDTSDNDSIDTSDKEDFPEVEDELEVDVSIFGEIEGLADVTLVVEDRRIPVVKAVLSLASPVFRAMFQSDFKEKNQEEIRLDGKKLDIFVTFLRCIYPDLEEEVTVENVYDIIYLANEYQVSRLLRSSEKVLLVEMEKFEDIEKENCCLEVYHHLAIADTCQLERLKAFCVSIASDACQADRDAAVEVHPVSSDIQRCIEKRVIRKQEIYLADYDALLGSLNHDSICDILKQKLQIVEKAPASFGTPIQNVQTHGGFTFTQVQQKQNKSSVLRGSPVSVSNAKGTTREADVQDLWKMHLRNLRWVYKHTPTDDKLKRQAIYWIRQAQQWFRWNIACAEEFSLLPEIAKHDIKGRYIMKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FH93</accession>
    <name>A0ABY7FH93_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="228" mass="24744" checksum="A531F2DED25E8985" modified="2025-10-08" version="1" fragment="single">MLFSVDTYMIFLHLPTFAISRGSSRMTASFLLPACGLSTIFARLLTTLLSERKNVDGMVLFTGSFGLLALATFLFPIYSRTFPGLVIFLVILGAYFGGCYAVMNSINIHLVCVKYLSIATGMELVFSAVGTAIGPVITDVPDVDLIVPNNREVNETTSSMVASAHSHIKRGDDIGNEKQETERQEFTAEQKSLVCSGAACSTPDSARDSVFISSEEVDFSVEVQKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLW0</accession>
    <name>A0ABY7FLW0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="9">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_036791</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="9"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd11845">
        <property type="entry name" value="SH3_Src_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 8" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="58"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="133"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR23122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="336" mass="38589" checksum="48A08480FE1AF211" modified="2025-10-08" version="1">MGCEKSKPKMDTSESKSSDIKGRSEENGDKPREKNDYTNPPVNLPQPGENSIVEGGSGGGKRVFALYDYDARTQDDLTFRKGDVLELIEGITGDNEDWCYARHTYPKCSNLQKEGYVPRNYVALEESLESHDWFFGQVTRKEAERNLLTKDNPVGAFLVRERESCPGSYALSIRDYDQNKANPDCVKHYKLRNMDGGGVYIVKRRQFKSMMELVDHYKVQADCICRSLAAPCSRAVPVMVDLSRDTQDAWEIDRNSLQLAQKLGAGHFGEVWKGMNNKEVLQQIADGYRMPKPLKCSDAMYEIMLKCWDKREENRPTFEFMECFFDDYFAYTELEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQZ1</accession>
    <name>A0ABY7FQZ1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MED8</name>
        <name evidence="9" type="ORF">MAR_036837</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074:SF9">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR23168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="135" mass="15408" checksum="078920CB026E90B6" modified="2025-10-08" version="1" fragment="single">KEEEQQRIALDNLIQRVTELKNSVGALIFKLEHEYETLKWPSVLDNYSLLSSQLQSLGKLLKGDKMPQLKNKILLPIFISPEPDESLAKLTENRVMMFNHEVAPSFLRTKPPPDVEEKTGLLTGKAQQLPQDQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FT47</accession>
    <name>A0ABY7FT47_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="105" mass="12140" checksum="49651753F84239F3" modified="2025-10-08" version="1">MLLQSAINGSDVSEADLRRLHLLNDTTVDVEHMKDIRGSQLNELLCVVIMFYAMALMVLIATQIRKQREYYDEYMERNDRLKDKNIMMATVASVPKDSSKRPTMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTJ3</accession>
    <name>A0ABY7FTJ3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="12857" checksum="203CA30C0062961B" modified="2025-10-08" version="1" fragment="single">MIYVYKHHYKESIILLAKKKYNENMATGGGPVGRITLTEEIVLEFLKDKPQLIGIPGGIESGVIESVEDAASVADLVVQQAPRSAWIELTEELHDLEVCRARKEIELLDLKIAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUT8</accession>
    <name>A0ABY7FUT8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PIF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_038277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13604">
        <property type="entry name" value="AAA_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="335" mass="37589" checksum="5A6AC605F8306151" modified="2025-10-08" version="1" fragment="single">METITMTLNDQQYKALEEHNVLIYGQAISGKPHLVNLMYEQLTECDKNVAVTATTGTACTLYKQLNAMTLECNDTAQVGGSWRRTTDFLIIDECSMLSEKLFECLFEVMKLKNGDKPFGGMQSNLFEFIPHKVALKDIFRQKDKELADVINKVSTGFVSESSMDFMKTLKRLLKCKTVDDFNRQHILENAGELFEFKSSDSGAQKQLDRLLAPKVSWIKVGVPYIVFLYSSSTFCSSHLWHNQSDPSLKLSDTLTISSKFKHLSWNHVWFNISSPVSMRADLPALLFRRFTCICGILGGTRMWPNDSGISPCATSGFTPKAPQVGHVSADVPVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FV99</accession>
    <name>A0ABY7FV99_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="345" mass="39521" checksum="8597404A2E27BD80" modified="2025-10-08" version="1">MSTNTSFVPSIFTSPMIMALKRHWNTMNLARTMPFQTLTVHGETVDITAAKIIRQGDCRKVAKKERNLVEDINASIFLDVTTSMPGNGKYLSNISWTYTALQEHRIPRKFILYFNFFHVNDIDYDKVCLVLKTKQSLLQKHLDAVCPLDNNQHDHSDDCRNNRLLLHYGDQFILVEENALQPAVDTSLNHSIIIAIVSATAFGSIVITTIVFVVRRCRTKKSSRSRPTIRTPVAVNSDSEMYNQQSSTGTEMQTFLSNNMTTKNDDLCSHSKKLHSNADLDIYRREEIKPLQYDPDIVSENHDYSKHEYDPEEHIKDDMRCRCNITAKRVYGLTVTSEGYCCNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWB7</accession>
    <name>A0ABY7FWB7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HBX4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_012171</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046919619" evidence="8">
        <location>
            <begin position="21"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="78"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="80"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR26467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="455" mass="51784" checksum="2FE50C4E4EFA6170" modified="2025-10-08" version="1">MLLLLLLLLLLVMMIMIVGTIDDDDDDDDDDDDDDDDDDDDDDDDDDNDDNDNDDRVSLFSYYNENDKTMTSVAEKDVTSKRGRIKYRPEQVEILEGIFLADHYPDGEQQERLAAELGVTLERISIWFQNRRSKFKRQRQSDHVAWMRAQIFQNEAGNPNKYTFGTPVLPPLTSACHVLSPLESQMTRGDNGLPFSQLPEQQTPTPNITSKKRVYISNDSKAGNEPTLETPKRRKIQHTINHQANYTPQQDSTVHHSVSPVFWLPRIQTIHTRAQPFQPFISSPMMYSGFYGNTHVHTPTNFPHHQCKIETDVSCADGPVVLNIPGNHPQDVIGHFELNRSLSLNCDNHQHSHKDVPRMSLPVTMPTTPTNAAPTHTIQQPTEFHDHLSTMSDITSCHLYDHHSNAENHLSRSRPSADDKENRVIGSQLNLSPSYCDPATDKERTLELLGHCVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXX2</accession>
    <name>A0ABY7FXX2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045347232" evidence="1">
        <location>
            <begin position="32"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="228" mass="26288" checksum="081A6B23C3EB5703" modified="2025-10-08" version="1">MSCGSFKRCSFLLSFWTWCKILFLNIWSCFKNIECCQRKHISNIQLYYEKGSDLTFRKNFVRKFTAVNFIDCRTQTLINAPEPLVVLCSFQTRIEDTCNAAMEGLQDCQSVVLVVFRRITGSVTKESIVSDLYIHPGVKETIYVGFDKNNIYFSPMDIKTLKTFLENNSDEKLLSIQNNGKDVRVWYRSNNFDGLDPNFGVNFTDKGVNALIEEKAFPEEAEVALLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZ53</accession>
    <name>A0ABY7FZ53_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="186" mass="20690" checksum="37FE3C50C2033109" modified="2025-10-08" version="1">MSSDSDPGLCKTHNYYAQLQGEMTVTGLPWCDFVVWTANATCPTPACDDATNEVCENGYCKIRNVYSGPNPNKDSSTFHSCCSYKCINRGYRKEYQHNYQTPTTTTAPSIPAVPTSASIKDTGKSSSTTTKPQQRQQHLPFLLFLQVHQQGIQERVAAQLPNPNNDSSTFHSCCSYKCINRGCRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZM6</accession>
    <name>A0ABY7FZM6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_013374</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="39"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR27670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="137" mass="15289" checksum="4391BE0556AFDD2B" modified="2025-10-08" version="1">MFIQCVNGDAKVMKCYSGLVFDPSINTCIPRESLVCPDIKPCAEKDSGYFPHPVNCRKFIQCQQKKETVMECHGDLVWSIAVNSCVHKTSGIKCYNINEAMNLSIHAIVGVTSPYQLVVTVFHGNIIQPTFNMNTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G068</accession>
    <name>A0ABY7G068_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MOT14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_013519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR27815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="586" mass="64127" checksum="AB4869FC4727FDF0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0Y6</accession>
    <name>A0ABY7G0Y6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_013806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR28102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="303" mass="33828" checksum="BD55DB9D8EA8A76B" modified="2025-10-08" version="1">MLEVMDCLLEPYSIERLSRSFNLAENLTKINLDYNEFGDEGCRNFCKGLENNTTMLSVSLCFCDLGVPSGASLGKMVSTTAVRDLYLDGNNLKCEGAMELINLCVEQAEIEALQRAEEAKRKHEEEEALKTAVNTYGSSTAKETKLRYTGDSGTEAGAKASDNEGGKEDKGKKKKKGKKKKKKKEPPPPPRVGPWIHKLHLADNAIDNLAFGEQFAPVICMRQFKKLLMHSDCIEELDLEDNWIGDMAGREILEALEHRKDEKMGGVKMRTTHKLSADVFNSIVKLGTGLKKKKKKGKKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1J9</accession>
    <name>A0ABY7G1J9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Very long-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">MAR_014042</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="30">MELC-2E11</strain>
            <tissue evidence="30">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:19181"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.8.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:19182"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>dodecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:47297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>eicosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:74691"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:47237"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:71412"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:47241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>tetracosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:74693"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:47233"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Homodimer. Homodimerizes after import into the mitochondrion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 25">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.9" evidence="16"/>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd01161">
        <property type="entry name" value="VLCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049448">
        <property type="entry name" value="ACAD9/ACADV-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF11">
        <property type="entry name" value="VERY LONG-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21343">
        <property type="entry name" value="ACAD9-ACADV_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 25" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 25" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 25" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="28">
        <location>
            <begin position="72"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="27">
        <location>
            <begin position="184"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="26">
        <location>
            <begin position="298"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="ACAD9/ACADV-like C-terminal" evidence="29">
        <location>
            <begin position="478"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00046812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF21343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="WAR28338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="604" mass="66158" checksum="8FC4A33E8A23FBA8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2G8</accession>
    <name>A0ABY7G2G8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TNIK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_013027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051700">
        <property type="entry name" value="STE20_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096:SF1">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR27323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="171" mass="18981" checksum="1AC4A72833FCDE9F" modified="2025-10-08" version="1" fragment="single">DPAGIFDLIEVVGNGTYGQVYKGSHTKTGQLAAIKVMNVTEEEEEEIKLEINVLKKYSHHRNIATYYGAFIKKSPAGKDDQLWLVMEYCGAGSVTDLGLAHLHANRVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDKTIGRRNTFIGTPYWMAPEVIACDDNPDATYDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4A1</accession>
    <name>A0ABY7G4A1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ZNF28-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_002838</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR29270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="397" mass="44834" checksum="DF518D496DBBDC27" modified="2025-10-08" version="1">MPTREKPYKCERCDASFTLKGSLKTHLKIHTGERPYKCGICDAAFTLKSNLKGHKLIHTGEKPYKCEICDAAFSLKSNLQGHRLIHTGEKPYKCEICDASFSSKNSLKTHLNIHTGEKPYRCEICDAAFSQKGNLQSHKRIHTGEKPYRCEICDAAFSIKSILQRHKRLHTVVKPYSCGICEASFSLKVILKRHMGIHTGEKPYICGIYDAAFSLKSSLKEHLRIHTGEKPYTCEICGAAFSLKGNLQSHKRIHTGEKPYTCEICDAAFSQKGNLQRHIRIHTGEKPYNCEICDAAFYQKGEKPYKCDICDAAFGLKGVKPYKRGVCDAAFSQKGDLKSHARIHTGEKSYKCEICDAAFSLKGVLQQHIRKHTGEKPYKCETCDNAFYQKGVLQQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4B4</accession>
    <name>A0ABY7G4B4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_002855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034720">
        <property type="entry name" value="Viral_alk_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF3">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01771">
        <property type="entry name" value="Viral_alk_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="105"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR29287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="399" mass="45504" checksum="375510B1AA500522" modified="2025-10-08" version="1" fragment="single">QVASDRYIEKLNVGGVQLPDPYSVAVKRWDSDASKWPSVLYPDIYYYLINYPGLYTAESLKAYKSLDGYNISIVLYHEVSKESTACLLKTKVTPSQRVNDKPHETWVCIDKKGRHVISAHCTCKAGLGEACSHIAALLFKMMSAALYGLNEKSRTSVSCAWNQFYRKKVQPKPLDMINFDNPKPLRKKRRRRVLSTSVENDDGFDAAEALRSLKRICPSACILTKGDSDTDTASEDEDLPPVLSRFHEVKHESLSPTDLEDKCQRFVRDFQVLPQQVMNLEAMTKGQQDSVLWQRQRRGRITATTAHDVLTLKQATTKSNLLKKIMKYHECDLSRLDAVKFGRQHEETARSITFPLFAATPDRLRECSCHGKGLVEIKCSYKHRDSKIEDIKDQTFFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6R7</accession>
    <name>A0ABY7G6R7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ESTD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_014465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027095">
        <property type="entry name" value="Golgin-45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13066">
        <property type="entry name" value="BASIC LEUCINE ZIPPER NUCLEAR FACTOR 1 BLZF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13066:SF2">
        <property type="entry name" value="GOLGIN-45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00390">
        <property type="entry name" value="ATPASE_NA_K_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR28761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="640" mass="70722" checksum="197772C7282D08D8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G764</accession>
    <name>A0ABY7G764_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SRCRL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_003345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047548780" evidence="4">
        <location>
            <begin position="20"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="5">
        <location>
            <begin position="266"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR29777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="459" mass="51984" checksum="87D360464EC3A3D2" modified="2025-10-08" version="1">MFVWCFSLALVLLPAAAVGDLEALTLEISNLGRKVDSFQSFVLQDILSIKDKINKMDSKIDAMIVNEKTDKEKDQAQSGSQTHEASSLNDKIEPMTLKKQLDRIRRGFREEKEAIRHDLDDLKGISQNLLVGKDQIAEYLITLETNVHTFLSKIIGELKDGILDITKNVQNNLSTSIERNEMGIDEKVQSLKELVQQTDNICKSISDNITETLTTALSASETTIVGHLNGTGLKTAALVNAVTQDLNTIKENIDTIITNANINSPVRLLNGNKSLNYMYGRLEILHDGVWGTVCDDEFDENDAKVACKMIDLNFTKYIVRTRAYHGRGSGMIWLDDLSCNGDEKSLFNCPGVVIGKHNCNHGEDRFYVRVYPPRVTLEFMGNLPLVLKSVRSEEYLRNWCYFSCTKLYIICKEKKNNKLKDSVLTVVLCRRMNRWTTNMSISIIRFPDGRIKTKQKHTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9H3</accession>
    <name>A0ABY7G9H3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">carbonic anhydrase</fullName>
            <ecNumber evidence="4">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_033099</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF141">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="15">
        <location>
            <begin position="2"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR30557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="244" mass="27186" checksum="7CA5ABD9F4718BE6" modified="2025-10-08" version="1">MAHWGYMTKNGPSTWGKDFPIANGERQSPIDIVTSAAEYDSDVQGSSPLSTNYTPESEVKLVNNGHSIMCQITKKGVLTGGPLGKDEYRLEQFHLHWGAEDGRGSEHTVDGKMYASEVRYSYVNTLHLVHWNATKYSSFADAVQKPDGLAVLGIFITPGVACNQFKVISDNCANTSDYWTYLGSLTTPPLFESVTWIVFKEPVEYSKEQLSALRNLVDSDDNPMQDNNRPPAPLKQRKVKKTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBE5</accession>
    <name>A0ABY7GBE5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_033341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="702" mass="79966" checksum="874DC1476723E3CC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GEC5</accession>
    <name>A0ABY7GEC5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-Fucosyltransferase</fullName>
            <ecNumber evidence="6">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_034446</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">Golgi stack membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 11 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd11301">
        <property type="entry name" value="Fut1_Fut2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927">
        <property type="entry name" value="GALACTOSIDE 2-L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927:SF9">
        <property type="entry name" value="L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="8">
        <location>
            <begin position="385"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR31904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="604" mass="68918" checksum="79BF28678D330E9E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GET8</accession>
    <name>A0ABY7GET8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="49891" checksum="7A286E6CF8CAA3F0" modified="2025-10-08" version="1">MCPWCCSSPNEFKYPHDLRRHIRGQHSHQHSSIPQKLLATSNLAYCCTNPKTFLSIEPATEYSSEEAILMRFLISKMAISHNTSRVGEDLSKAHFNPNILSDNKLNARLLRMMTSCQVPSIPSGGNWLHTPDALDQTSIILGISKEYIRTTERQTLPSFKTARIASLISSTQPVSTFNPTTSTYTTPSSSTYSHPEMHQFKPITTSNSAALPMSSLTESMPLNLNDLRSPTPISISEPLVDVPTTPDLNTPPNRSPHQKSATTVTLNGDSHDHSKPPASGIPTSNKRFTDSSITETTALPATIWNDHLNETTTPLSPSLLPSATSLFGIATFNATSPFSDINTPVTQSPSQDHLVTVPHLSDNTNPTGRSVPPTTDTQYSIFTFQETTDAPNTNNFPPEYISTPLTSTKLIESSAKSLLFTGRIPLLPPDKRDWTSIKPQSITLGPGLNGPHPTGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GF40</accession>
    <name>A0ABY7GF40_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="811" mass="92538" checksum="FAFFF85580ED220F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D7B9</accession>
    <name>A0ABY7D7B9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ93571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="172" mass="19488" checksum="4242351DC323F73A" modified="2025-10-08" version="1" fragment="single">MNGVNGNEGLSTFLEILNAPLNDMIVTKEMMDNDYIPKYLPYMYPAQEVPHDVQKVIAHEYTNWVDPEDATRMFVKYAGDVTYNVDSMHLRTLRADGEGSRTNPSGNDSITWPEYEQDSMRHLVLDRTDSIGTRQFAREVAFWRELVPDMMAANEACTKDKGPGDMIASSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAS6</accession>
    <name>A0ABY7DAS6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_007242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="55"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ94771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="361" mass="40617" checksum="023370340915EFAE" modified="2025-10-08" version="1">MALSILYWSRYVDGHVKLTRKSEAAVESGRVLRFSIDELRVIQANVQASMRGKSYSVQIFLEQENNGAVQSTRCQCPMAEYKCHHVAAVLLFGYKRVSKTDIKCTLHWILLEEPKPPQLPLPLIEDVLVSPGYLSSQDPRTYFRRSFVLSQEKITQIVFMTTRQRENSLWAAARKLRFTASNFGQIIAASKRNRLCASLKKRLLSAYNLQKRAPIQWGITHEKNGLDAYCRTGGVTLVQTGIWLHESGILGASPDGFVQGDYCGRVHLQDKEQPVMSPDIIEVKCPFSAKDMTITEACHSNKDFYLDAIEKDRTVLLGTVNSDSLECPIIKRNGPLYAEIGCGSDIFARFLCSNRIFSAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCG6</accession>
    <name>A0ABY7DCG6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FA5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_007207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047273379" evidence="2">
        <location>
            <begin position="31"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ94736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="388" mass="42850" checksum="05617090E32EA616" modified="2025-10-08" version="1" fragment="single">KSKGNPNNVKCTCIALVFLCTCVVPKCTSAVDDILRKGTELFSLIRRYGGLIVSELPVGIQLKEDTFLLNCHEPRSGLVSQIADEPDTLYFHLESALSKALEESDKLFMSIGNSTASTIGIKRESNGSFVVMDSHSRDDKCMCSQNGKAVVLQFRTLAALVQYARDLAKSLSANKNMQYEVTALSISKSSASLETITLDGNDEENDRESLAECFKLNAPDTDVQHMQPDAVDQHVQPDTVVQHVQPDAEEQHMQPDTGEQHMQPDAGEQHVQPDAGEQHVQPDTDVQHVQPNAGEQHVQPDADVQHVQPDASEQHIQPDMDVQHVQPDAGEQHVQPDTDVQHVQPDAGEQQKQPDTDVQHVQPVTDVQHKTQTENPVQVQLMDIGNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DH26</accession>
    <name>A0ABY7DH26_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="56663" checksum="CB4BCB4F83B0C0C4" modified="2025-10-08" version="1" fragment="single">LGRRTEEEIREEHRTLSCDERNQAEFAEKIKKISEIERQLSEDLSNKEHKILELEECVSKKEETIEVLNQELTQLSEENSKLSILIENIEENKGAVTALKHQQLNQISKIHEENSILQQRCDDLERARNDLSAQMNDVLAEKQDVYKEFEAQQLARTALTDSDFTPININIKANGEQTCDVHGILCIGPGIFVLTDWDNKSLKTVDINKQSMLSVLQLEASPFDVAKLKPGILAVTLPRLKQVALIKFNSDGELGLSKSIKLKKECFGITSLDYAHIIVVNSNVEVYDLRGNCTNILVDMSYDRMKTEFKELKYVAAFGDKLLYLTDWALNSVTCLSMDKEIKSQFKFSGKNLLDHGAPLGLAVSLAGTVFIRCRKGVYLLDMDLRNGRSLASSLPRGICLSYSEWDQKVFVAFTKSNIVIAMASRPPKDLISEVQWYHGNIDRIETESRLKMIGQPFKDVSTLIEYYKTCEVSLVNATQSQCYRTSLRRFPNKFERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHH9</accession>
    <name>A0ABY7DHH9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TMM26-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_028604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168">
        <property type="entry name" value="TMEM26 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ95914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="303" mass="34442" checksum="1E0564B2A9178694" modified="2025-10-08" version="1">MTKVSKEKDKNKSKEPEKDEGKTQIKYKSNPSMTKVSKEKDKNKSKEPEKDEGKNPCLLKFCYIRLLLIIHCVLACWRVVVAENDNRFWFLCCLNVLFLVEGFKTFNREKPVKRWRPCIAVYLITILPCVWLLQIHRYNVAAASMGGEDITTTQSTTVVSTTGSNGGSTTTPGILMSFANTILSKDDSTWAVVIQELMIFLIKYTIWFLKTKPKKLKLARFIAKASDIMELFALFDESAVQEDLTVTYLVLSCWSLSFIQFVLVLPKKGIARQPPVSDGANTSRNGWLLYSIKTVDEQANKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHK2</accession>
    <name>A0ABY7DHK2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_028634</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAQ95944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="444" mass="50587" checksum="20488B0DAEA198E2" modified="2025-10-08" version="1" fragment="single">TGAGYSRQGLVIADRDDGMEGHKTPPEATAGDGAGVHHMIASTFQNTGDIDGYFRQLLQADMTWNNSGSVQLQIPEIMVELNVTKKTTQKPKPLVKKTDGYNLASRVRAKCSAPSGRFAVHKPKLGTYQSGKTELCIIWKVGTTFVKRLFMMKTLPKYQDLINPYDISFEQDLPGKRSPIAATTRFMFVRDPYQRLVSAYVDKLVAPNPVYWKIISVNAIRQLRKNATRLSQQCGHDLTFREFIQYVILTLDPRVLRKPARPDGHFLIQTDICGPCRVKYDFVGKMETFGLDSIELVRKMQISNKTIDLLQQNGSVLASDDAIRDSCHQPFHAGFKKAYINCISFYEALKRAWLKMQMRGLIGPEEMPLTEAQSTTLTLEQFYQMALKSRDACPSSERKKLQHEHFLKSYSTITPQELEKIRLIYAQDFKLFEYDDRPSELFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIG9</accession>
    <name>A0ABY7DIG9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_007276</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="120"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="459"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="554"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ94805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="575" mass="64260" checksum="F9D610D054205DBE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJS8</accession>
    <name>A0ABY7DJS8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/arginine-rich splicing factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Splicing component, 35 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Splicing factor SC35</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Splicing factor, arginine/serine-rich 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_029635</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12311">
        <property type="entry name" value="RRM_SRSF2_SRSF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051106">
        <property type="entry name" value="RNA-bind/splicing_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48028">
        <property type="entry name" value="GLYCINE-RICH RNA-BINDING PROTEIN RZ1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48028:SF4">
        <property type="entry name" value="SC35-LIKE SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="14"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="88"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="101"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAQ96945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="186" mass="22166" checksum="4866FB74F4D02C95" modified="2025-10-08" version="1">MSYGRPPPDTDSMVSLKVDNLTYRTTPEDLRRAFQKYGEVGDVYIPRDRFTRESRGFAFVRYFDKRDAEDALDAMDGTVMDGRELRVQMARYGRPTDPHRRSSSRRYGSRRRSHSRSRSRSRDRRRRKYSRSRSRSYSKSRSRSKSRSRSKSRSRSRSRRSSRSRSRSRSRSRSRSRSPDKVQEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKB9</accession>
    <name>A0ABY7DKB9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GEMI8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034754">
        <property type="entry name" value="GEMIN8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16238">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16238:SF7">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15348">
        <property type="entry name" value="GEMIN8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="331" mass="37324" checksum="1C535BC494990E4E" modified="2025-10-08" version="1">MASTNQQEAMSCSDLDIASQSGTDIGNGSNDESTTPTGETVTEDSEDGVCNISIEFTEVSDLDPTLLDTEYTGSDYDESKPEQPKIDKFQFLQDIDFSSRNWYRNDCFRAYWEHYSQSMSWCQKHFQTYNNVFKRTRSQFAQHSPFPSFVNPNQYPSFNCDFNFVRPSQYPSSNSGRSNRVPSEIGSISEASTGSKSRPRRRRGGKKKSKNKANSDINSTTPDAGTTGSEIEMEITQDMIDFFAKSDEHRRQRVKVGGERVPTVDAPKERPGARRTAEMKLLYGKGAAMIHGMETALQMAFDRNTDTKQPRVWPNMPLKIVFSSSTKSQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKQ0</accession>
    <name>A0ABY7DKQ0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_022630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tumor necrosis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471:SF13">
        <property type="entry name" value="TNF FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471">
        <property type="entry name" value="TUMOR NECROSIS FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00207">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50049">
        <property type="entry name" value="THD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="THD" evidence="7">
        <location>
            <begin position="180"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ98257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="330" mass="38362" checksum="5F0D658781C0C089" modified="2025-10-08" version="1">MEHTKGESSLDFLFQAKIMKNDADNYDQEEASEPLKSASLKNGLPDIQWSEPQYSRQSSNRKKDNNHMYKISICLFGFLNVLLLILNGLAVYYLASEKAPPQPTSRLCVRCQDIKGHPDDVKTWKHIVQENDTCCLDDPKHLNYLVEYYTERWMKTRLTNSNKTFQYCKDPTRDEFQARPSIKVMGFSEPQIHSEHHRMHWDQNHQLALVPHPSKIRYLEDDAQIEIKQAGLYHVYSQVHFDHKQNDSLQSVVFSHVIYMKKAGTSIGEETIVMRSRETEGESEDRRVVGSSYLASSLQLEDGDRLYVKVYTKDDVLAEPHMNFFGVHML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUA1</accession>
    <name>A0ABY7DUA1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Long-chain-fatty-acid--CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_025041</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006134">
        <property type="entry name" value="PRK08279.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF22">
        <property type="entry name" value="VERY LONG-CHAIN ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="57"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="497"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR00669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="626" mass="70528" checksum="E282876D8E4D78EE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DV69</accession>
    <name>A0ABY7DV69_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZAN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="569" mass="65246" checksum="C588735D22619914" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXB3</accession>
    <name>A0ABY7DXB3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GGT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="307" mass="33264" checksum="71A0A774F7BD4A01" modified="2025-10-08" version="1" fragment="single">IGANAAISTGVQKCSDIGLQMLTQGGNAVDAAVAAMGGFMLVHDHKVEKSEVYDFREMAPNQAKPDMFSADSSQKELGPLYVAVPGELRGMEKAHKKYGILKWKNVVSPAADLARNGFHMTGHTDCECSFQNSDYKCSFQIVNAHFRIQIIVNADNPGVLTKEDLMSYSYTVESVPAPGGGPVVLFILNFMEGYGKSAQDNATYHQLVEAFKFGNAHKEQLGDPGKEEAAKLRNLTTDTTQDASFYRSKIKTPEDAGTAHISVIDTAELMVSVTTTINTWFGSMVLTDTGILLNNEMADFGESGDPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYP4</accession>
    <name>A0ABY7DYP4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LRIG2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_008349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF307">
        <property type="entry name" value="TLR4 INTERACTOR WITH LEUCINE RICH REPEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR01791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="292" mass="33638" checksum="A29CA27C97F82F19" modified="2025-10-08" version="1" fragment="single">FIRFVSENELQTFPHQVLEEGFYPNLEIIFADNNGIQNMTEYGEEAFLTSQKYLWTQKKRNFHFAFTTYPALNTLYLHGNFIADIERDDLCNMTNLQNLFLGTNLLTEDRIHDDAFQCLPILDYLDMGSNFIQYVPNALKNSSVLPALTQLILNNNKITFIESGTFTNVTTLNLLYLTGNGIIAVENEAFNDDIAYLHIDYNEFRFTHKYPFSNLGNLRELWLSGNSIDYIPPNAFQNCTSLLEIQLAYNNIPQLLKSHFENCPLAGDLLFNDNDIGYIEDGTFDHVTVMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYW3</accession>
    <name>A0ABY7DYW3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_008351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="58" mass="7039" checksum="7AFC8182E5598502" modified="2025-10-08" version="1">MMTHFPGRLTYRHCAYRITTLKKYRRASSMISQVFRYCTSRTTRSRLSGRRCSMPWFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0G2</accession>
    <name>A0ABY7E0G2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PIWL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_009050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd02845">
        <property type="entry name" value="PAZ_piwi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04658">
        <property type="entry name" value="Piwi_piwi-like_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23278">
        <property type="entry name" value="Piwi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="3">
        <location>
            <begin position="198"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="4">
        <location>
            <begin position="455"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR02492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="734" mass="84450" checksum="3C7E0572CA798BFE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0R5</accession>
    <name>A0ABY7E0R5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ASO-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_010156</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd13858">
        <property type="entry name" value="CuRO_1_tcLCC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13884">
        <property type="entry name" value="CuRO_2_tcLCC_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13905">
        <property type="entry name" value="CuRO_3_tcLLC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="127"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="240"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="505"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR03598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="690" mass="77821" checksum="66FD32290676B835" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1S2</accession>
    <name>A0ABY7E1S2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PACN2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_009717</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd07655">
        <property type="entry name" value="F-BAR_PACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF11">
        <property type="entry name" value="SYNDAPIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="7">
        <location>
            <begin position="44"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="480"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="209"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR03159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="540" mass="61130" checksum="DABD5A7EE37A554D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3A8</accession>
    <name>A0ABY7E3A8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF25">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="572" mass="65782" checksum="CF0CC7702AD428F2" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3I3</accession>
    <name>A0ABY7E3I3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription elongation factor SPT5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DRB sensitivity-inducing factor large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Transcription elongation factor spt5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MAR_009532</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06086">
        <property type="entry name" value="KOW_Spt5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041980">
        <property type="entry name" value="KOW_Spt5_6_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057934">
        <property type="entry name" value="KOW_Spt5_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024945">
        <property type="entry name" value="Spt5_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23288">
        <property type="entry name" value="KOW6_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23287">
        <property type="entry name" value="KOW7_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01104">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="14">
        <location>
            <begin position="176"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="15">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="15">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="15">
        <location>
            <begin position="563"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="15">
        <location>
            <begin position="668"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Spt5 C-terminal" evidence="16">
        <location>
            <begin position="723"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="15">
        <location>
            <begin position="941"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="629"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="706"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="743"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="822"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="842"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAR02974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="994" mass="109644" checksum="F879DB1A62300641" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3I5</accession>
    <name>A0ABY7E3I5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19775" checksum="8BF24F42AD10ABA0" modified="2025-10-08" version="1">MRSEGDDPDSSTYKLWHPQKTVLMFNTEIRKHVQSCKRDRKSEKPNVGFQIGFARTPNTGACRIQNSATVIAPSISSMQKQATRLYIIRAPLGDTAVACVYALLFGKSQEVYEELFEVIAIARRFLTDFELAAIRAIETTFGQHVNHRGCFYHLTQSTWRKIQALALVERYKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E487</accession>
    <name>A0ABY7E487_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="317" mass="36513" checksum="0195764EDAA0E8A3" modified="2025-10-08" version="1" fragment="single">YNNASFTIFGDFNAHCGKLLDYVEFDPYVADNNLDDIATRQMSIKNHLDLGIPLERFSLDQSNINNYGYRLLYLCKSTGLCIANGRCGNDMYLGKCTCKNTSLVDYLLLSHCNFPNVDNFDVNDFDPILSDAHSSISLKFCCHNLSDITDKHDNDFDVDFIEDEVKKPIWDNTVKERFLSSFDEDALLNLQLEVDSIFNNKKYCEDSINSLTNKVSELFVNAADNSNLIVAKKTSMYKPHTSKKKSWFDADCDTARKIYLHDKNYYRRIKTVDSYDTMVNVVNVIKRQLTRNLRSNDPKAFWNLLKKYSGDRKDAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4F3</accession>
    <name>A0ABY7E4F3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">OS9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_019448</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF5">
        <property type="entry name" value="PROTEIN OS-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MRH" evidence="7">
        <location>
            <begin position="62"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="439"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="215"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="322"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR04079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="598" mass="68532" checksum="F840635C05166F04" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4V3</accession>
    <name>A0ABY7E4V3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="98" mass="11134" checksum="DF30667D1DDFECFB" modified="2025-10-08" version="1">MRNYYVGFTNYLQHLYEVAKTEATANHDATRGTTPARQNVINDAKQPRYDKVELTAVILPIVIGIVAVIAVVAGVYWRKRQMYGEPEIISPYLIHTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5B3</accession>
    <name>A0ABY7E5B3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TLR4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_020557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TIR" evidence="6">
        <location>
            <begin position="110"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR05188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="268" mass="31711" checksum="9175C3A1A22769A3" modified="2025-10-08" version="1">MSKKNDLSYNNIEVFDVDVKTLNNLLHLNFRGNAVHKLNHLVRQLLEDNSERIGKNFTLDLRNNSIEYSCTNQRFLYWLLDHKERLHGFHEMVFYSLFNYIWSHFVQKEMETSVLVLHDKAKLLGYRRLVNDFKAENYRYDARKYTKTGGHTGMKLCVHQRDFLPGIPIQDNIVDAIRTSKKTVVILSKNFVMKQWGIFEFNMARMESIDKRVSENGCLVIVLYENVPAKIMPLEILDWIEHHSYISYTSDPDGQPLFWENMTTAIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5N9</accession>
    <name>A0ABY7E5N9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BET1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_010282</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="31"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR03724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="123" mass="14012" checksum="EC48F6008DC81B3F" modified="2025-10-08" version="1">MEVILMTEQRCVCVSAGEGGWGEAQYQPTQDMLEQENSRHEELLSTKVKALKSLTIDIGAEVRDQNKMLHGMDDDFDSSGGLLEASMRRLKAITRMGGHRQMLYLILFCLFVFVVCWLIVRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E798</accession>
    <name>A0ABY7E798_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DCE1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_019810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF10">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="315"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR04441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="354" mass="39071" checksum="C9974235EE1E6414" modified="2025-10-08" version="1">MEETVLQRIKQLIGWSDGDAIFAPGGAISNLYGLMVARHVADPGIKHTGMADGRKFASNFSIKKAAVLLGIGLDNVYSIQMVARGRMNVAALEEAVQSVVSGGTVSLFVNATCGTTVLGAFDPVNPIADVCEKYGMADSMTWNPHKMMGVPLQCSAIFDKKHGVLQSANELGADYLYQKDNVYDTSFDTGDKAIQCGRHNDVFKLWLMWRSKNILGLSSFAFYRSISTRYNMLDKLKAREDFELVLEELTACLKGLMMEKGSMLLQYQPLGSMPNFFRIAFSNSAITRTDLDFVVQEIVDLAEKLQRMVPRMADLGQTDRDSLPSGKEMHVTGSNINEMGDSERQGEGQTEDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8W2</accession>
    <name>A0ABY7E8W2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="344" mass="38249" checksum="D84B4296451A38F2" modified="2025-10-08" version="1">MAMLLRRRQFAGLVRAVATTTKLASQVSQLSLFMSNSAKSKNNASFEVSDLFGGKEEKVETISDNEDLPKTQDEPIETAEAKHEPEHDIEETVHDVAVEDLKTEESKTNNISVKKPKGYSKYVSSIVSVSTPEAGFYQLQTLLLASDISSGEKVLLAHSALVRILNLTSAQELVKDSSFETLADFVDINGVSLLSDALLSKLSEIVLQVATERLLELVENAGANDLIDTMFRIHSHPHLGPLLDDIALKNLSEFSTTSLYQLLYMQAKNAPATKVQNVKTSLLYLLGVLHVQMGVSSFPVHDDFNTWRTQLQEKVPHTQWMRHISKRIDQLTYLDGLIQKCVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAU8</accession>
    <name>A0ABY7EAU8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_021291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="4">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026876">
        <property type="entry name" value="Fn3_assoc_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13287">
        <property type="entry name" value="Fn3_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0041">Annexin</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="553"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="933"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR05922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1270" mass="141174" checksum="299F7CFE889FCE58" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAW2</accession>
    <name>A0ABY7EAW2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTPRU-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_021484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="88"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR06115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="214" mass="24685" checksum="8A87DA9B784BF1C6" modified="2025-10-08" version="1">MYSSAGVGMTGTFIALDYLYDQGKVDEKLNVPETVNVLREQRVCMVQTKEQYLYLHEAILELLDPVGLIFTPENSMRFQSTVTEYRKLIKEFKAITDSIVNVTTVENDNDFDRMPDGQLPENKCKSIDMNVIPDDMFRPLISSGNDFINAVYIPTYRESEKYIVTQFPLQNTTVDFVRLLWDHSIRDVVLLDQDDEKACLQISAEIKIRSHIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBP7</accession>
    <name>A0ABY7EBP7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CBLN3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_021731</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF116">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="111"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR06362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="286" mass="31662" checksum="20DA14A4A6194EA2" modified="2025-10-08" version="1">MLLKLTIGKISKIVCEEEEEEEEEEEEEEEEEEEEEEEDDEKEEIEEKIRKRITFIVPIISVNVDGGLPPLEEHVISAGSPSFSVGTARTALSGLTGDFLNGNQRLKRQDLPYGTVAFYAALSRTVANLGVNQNIVFDHVILNEGNGYSGHAGDFRAPVTGIYAFSVSLQSYYGHSTHYTIMQGTTLVGKLYVDGHAAGMENSGMSFVLKLQKNEDVSVKNADLGENLHGDHYTSFSGFLVAEIEDNPVVGSPKTTCAYEWVRFPLRGPLCDTYDTVYCKAVRSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECB0</accession>
    <name>A0ABY7ECB0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centrosomal protein of 162 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_016717</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CEP162 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038774">
        <property type="entry name" value="CEP162-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34031">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 162 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34031:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 162 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="31"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="214"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="328"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="586"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1032"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="619"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="684"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="870"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1079"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR06759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1308" mass="147724" checksum="76878FF67624D137" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECU7</accession>
    <name>A0ABY7ECU7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_016897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR06939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="178" mass="18891" checksum="7E4BFA922BD03B1E" modified="2025-10-08" version="1">MLCVWVGFTAADDDPKAFLEIDIPLDIRGLISCNEDVWNLQVCIVQQLAPVLDTMPGGAHRCDNNCTFQNYTAGDPKLHMCIFYKLEREYERLLDITKGSQSLMSKQTSEDPGGPGTGTLVGGALGGLAALLAALAAGFAIFKRLQRNKVDDDGSTPVLPGGDIGISEAPNSVPPAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDQ5</accession>
    <name>A0ABY7EDQ5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="353" mass="39259" checksum="AA31DCC6305B7F1D" modified="2025-10-08" version="1" fragment="single">VHVCQDSWASAGLVYLDTLYTPKLQSVVCWCFVTAQRKNAAVAASYTSGSNTDLQAFQLGITNLTGRENGLFFFNKTLEITYSGNSEHQVRPACLELFFKDYKEEIFNVSCRRFSKTKATQTKPESSSFSTLTTADNKSSSSLSTPHKRWSFIPTRPDKNLKFPSLTTAESVLPASKAESPNYGVVGQTSVCPAENSSVVHVCQDSWASAGLVYLDTLYTPKLQSVVCWCFVTAQRKNAAVAASYTSGSNTDLQAFQLGITNLTGRENGLFFFNKTLEITYSGNSEHQVRPACLELFFKGRKRDHIRPANSRIPTLTELTNTKWITSIERQPVKKQNLQRLTSPSPATYEKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDW1</accession>
    <name>A0ABY7EDW1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="110" mass="12623" checksum="482C34F8F13A4634" modified="2025-10-08" version="1">MRSLDKRFSLTEAEGRFQKACDQIVLLNHRLGEVQKRYKMAKRSNNKAFRYNLRLKLAVIEVCATCTTTSPTAKPTALLSFDVSFSTNPSKSSPDLTQNILLMTWSRHWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEB7</accession>
    <name>A0ABY7EEB7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MYPH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_017039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR07081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="177" mass="20032" checksum="28F9E3CAB15239F0" modified="2025-10-08" version="1">MSYRAAKAGLARDTQVKIDSQFDIDEAKKCLYWLGEMTGENVEIQETDDRREMADSFHTTLKDGSLLCRLIDAVLPEGQKIDFSKKSFQESKNQAFTMARERERIAIFINKCQEYGAQSRPGYAAPVIWPKKNETNVRTFSEEQVQAGKQVISLQYGSNKGANQAGMSFGKTRMILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFU7</accession>
    <name>A0ABY7EFU7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_017511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01335">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DED" evidence="2">
        <location>
            <begin position="39"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR07553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="402" mass="46011" checksum="BC8EB0C503B501E8" modified="2025-10-08" version="1">MNADRTQTNKLFQQKVNRYTRDNSHVMALSLASPPVDFAFNKLLLRIAAEISEDELRMLKERRAYLFPKQEECDSALMFLKTLRDRGVLSRDNIDILKVILQELNRKDLLTEAVKFFSDDFPKINVCESNKFLYCTNDNFEGLFSLKAVFDPNSIDRQTVEDVRSRLSNIVLVPCSAILVGPIRLRPLSVVYLLPELYQDCIIKAFSDKSCLSGMSSLGICRVEIKGENGYECVDICTKNMDAGNSVKQIVSKRINDLKQELNKSKAESAALDRELVETYIKLHEAEDKLKKGRDMENKLAMLHISSGMSTTLWKLTGELNEDNNPINKPEKSHDEINRECLYKKIQRIYPHIDNERNPTVYRPNQGTQYGEQNYGIAVKSHIDTPLVVELKHKPSLNTKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EG16</accession>
    <name>A0ABY7EG16_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NPA1P-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_018778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="3">
        <location>
            <begin position="89"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="900"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR08820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1349" mass="150661" checksum="F85EEB61848B1FC2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGR4</accession>
    <name>A0ABY7EGR4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">KIRR1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_018263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045543912" evidence="6">
        <location>
            <begin position="26"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="27"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="126"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="214"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR08305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="320" mass="35161" checksum="1032FBEBB02F88D0" modified="2025-10-08" version="1">MGINMERVLLAGFFLIALLLSGSDAKPIEVTISARRGVEVLLPCSLDSDMDPDNVSVRWSSSKDSFITSGLRVLKYVNQIEVVKMSKMEWNLLIKSATDTFAANYTCMADQKVLLSNVQLLILVAPKIDFGGTSSPVVNVDEGGTVELTCAFTGEPVPRITWLRGDDKQATGITGRKLVLRDVKRYATDVYTCRGENSVKNNEDYTMNLTVKFPVEVDVMEKTIKVMKGGVFTLSCFAQGAPLYDTYWIDNSGTKVTATPWKYKFVVEPVGAHVPAKFVTLETKPGTFTAHDFGTFTCVAEGEGHEARATVEVVELKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EH12</accession>
    <name>A0ABY7EH12_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">KCP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_019235</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052424">
        <property type="entry name" value="Kielin_Chordin-BMP_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698">
        <property type="entry name" value="CROSSVEINLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698:SF6">
        <property type="entry name" value="KIELIN_CHORDIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23334">
        <property type="entry name" value="VWC2L_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047155299" evidence="7">
        <location>
            <begin position="23"/>
            <end position="2629"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="327"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="374"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1051"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="1099"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="9">
        <location>
            <begin position="1907"/>
            <end position="1965"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="9">
        <location>
            <begin position="1965"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="9">
        <location>
            <begin position="2031"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="9">
        <location>
            <begin position="2125"/>
            <end position="2184"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="9">
        <location>
            <begin position="2207"/>
            <end position="2264"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="9">
        <location>
            <begin position="2264"/>
            <end position="2325"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="9">
        <location>
            <begin position="2345"/>
            <end position="2409"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="9">
        <location>
            <begin position="2409"/>
            <end position="2470"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="9">
        <location>
            <begin position="2530"/>
            <end position="2589"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="242"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1082"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR09277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2629" mass="298116" checksum="DE9B893E34EAE9CD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EME0</accession>
    <name>A0ABY7EME0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UNC89-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF4">
        <property type="entry name" value="MYOPALLADIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="60"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="163"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="282"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="428"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="740" mass="83919" checksum="86352019AA15F5E6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7END4</accession>
    <name>A0ABY7END4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="173" mass="19343" checksum="AA88911F2BCB3272" modified="2025-10-08" version="1">MNPGGKEVTTVSALNSLPTSIDGSLFQASGFNRNVNEEEIDGTAVSAQPLDSDIDFDADTTELLAGLDIESLISESPNTVQRPNLSLPEDVKIVEKLISLKFQEPLRENQTVYNHFIQYLLDNNEKLQEFCATQYFHLLEMFNETVKDSKTQKAQTAFFKAFQSHLTSGVYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENJ9</accession>
    <name>A0ABY7ENJ9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_025595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR11415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="113" mass="12747" checksum="5EEA61C644893B0C" modified="2025-10-08" version="1">MPYKNYSHEALAQAISAVRRNVLSQRAAAAQYGVPRSTLRYGVGQKKKGTQTGQSRMLTDVEERALVTYIIYMANQCLPHTRDITRCYIRDIIVDSGQATLFDMKDGPSDKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ER97</accession>
    <name>A0ABY7ER97_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MATH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="794" mass="91301" checksum="FED100981E947514" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESM1</accession>
    <name>A0ABY7ESM1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_026284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd10229">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR12104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="632" mass="70803" checksum="FB2F148422FB2A4F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESV4</accession>
    <name>A0ABY7ESV4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026534</name>
        <name evidence="2" type="ORF">MAR_026535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF13">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="137" mass="16441" checksum="64613C60A3D9AE4B" modified="2025-10-08" version="1">MEYGVIECVRFCFTQILQHELDTVRQEWNDHPIRRQNGDEINGRPEILYQHPDLYECVRFCFTQILQHELDTVRQEWNDHPIRRQNGDEINGRPEILYQHPDLYGTRDYEFPVEMADVVTFRSFCKTLAVKSPCKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVC1</accession>
    <name>A0ABY7EVC1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IF44L-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFI44 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241:SF32">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="358" mass="39138" checksum="946583406A6CEAB1" modified="2025-10-08" version="1">MAGQLTDADMDQLETWVGTGPKTFTLLYKITRDGCDPAIFHQKCDSQGPTVTVLYNTNGSVFGGYAGQSLHSQSAYINDHTAFLYQLRFSGNQKANKFPVKCSQADYAFHGSPSLGPVFGAGHDLHAFSAKISNNSGTFALNGRLRFKWGAESENGETKGSQTVAKCSRTQRQGLLDQLKEEIATFKPQSDLDLTDIRVLLLGPVGTGKSSFYNTVNSVFRGRISQRARCGTSAHSITTAYKPYTVGKQGGSRLQFRLCDTRGLEVSQGLDLLECNFLLDGHVPEHYEFNPATPITPETPGFIHKPGLADKVHCVLFVLEANTIDDLPTKLVEKMNSFQKLMNQKGRGGGGIVRKVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVY1</accession>
    <name>A0ABY7EVY1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="219" mass="24916" checksum="D522A6A06CEF32CB" modified="2025-10-08" version="1">MLVFKYLLPYLPSSLVMTQFKMLIVTLMRLKLNLSVMFLADEFSVSHAISVSRVFTNVMASARSFTKDNANAISEKTLERNLRQKPIADINTIILLYSLLEYQLKELCLLFLKAWVVEPATKRVIGNVSQKYSFLNRTVPIRYLMYKDENYFTVLDETAHVCCALVKLNASVACTIALAEPQQPHVRIPSDDAPRNGLSVLMNNPQSEMHIPSCSWFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EW78</accession>
    <name>A0ABY7EW78_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="1">PARP</shortName>
            <ecNumber evidence="1">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004315</name>
        <name evidence="4" type="ORF">MAR_004338</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.-" evidence="1"/>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd01439">
        <property type="entry name" value="TCCD_inducible_PARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF2">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR14210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR14233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="187" mass="21458" checksum="707BF9A2D17A1D8B" modified="2025-10-08" version="1" fragment="single">LDERKPSMKTEYNKIENMFSATMPSTVTIVSISRVENGDLWHNYLSKKAKLKKRNKGVDVEERQLFHGTKNDTMEAIYRQGFDFRLSGTASGTAHGKGSYFATTAKYSDCYTDRQRGTMVMFIAKVLVGDYTKGDKSYTRPPQKDPRDLSSPLYDSCVDSVTDPKIFVIFELGQVYPEYLIKYKYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWE1</accession>
    <name>A0ABY7EWE1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LAC2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_027449</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd13884">
        <property type="entry name" value="CuRO_2_tcLCC_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13905">
        <property type="entry name" value="CuRO_3_tcLLC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="57"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="163"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="459"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR13269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="654" mass="75056" checksum="DE7845BE32CB922B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWI4</accession>
    <name>A0ABY7EWI4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YMD3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="240" mass="28439" checksum="E0613332004E446D" modified="2025-10-08" version="1">MPYGSEGRAIKERKPKKMWADKGKEFYNKDVQNLVEIYSTENEEKSSVVERWNRTMKEKMWKYFSANSTNKYIDILNDLVDQYNGTKHSSIKMTPVETSMKKNENRVYKNLYAERKAPGTLCQPLASSKPKYPVGDRVRITKKKKTFEKGYTPRWTEEVFSVSEIQYTNPVTYKIKDYNKEEIQGTFYEQELQKTDQEIFRIERVIQKKGKKALVKRLGYPESFNSWVERSDLSDIKTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWY1</accession>
    <name>A0ABY7EWY1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MTSS1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030127">
        <property type="entry name" value="MTSS1/MTSS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15708">
        <property type="entry name" value="ACTIN BUNDLING/MISSING IN METASTASIS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15708:SF4">
        <property type="entry name" value="FI21477P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51338">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="823"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="870" mass="93610" checksum="A22FB3A33D61DA80" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXK4</accession>
    <name>A0ABY7EXK4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ARGAL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_003919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039919">
        <property type="entry name" value="ARHGEF10/ARHGEF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877:SF7">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19057">
        <property type="entry name" value="PH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="211"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="818"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="886"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1057"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="823"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="890"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="900"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="915"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1099"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1147"/>
            <end position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR13814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1202" mass="136703" checksum="C8B5899E740520D8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXK7</accession>
    <name>A0ABY7EXK7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRAM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053359">
        <property type="entry name" value="CRAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35577">
        <property type="entry name" value="CYSTEINE-RICH, ACIDIC INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35577:SF2">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="914" mass="96877" checksum="82B0CE526D5E8199" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXQ8</accession>
    <name>A0ABY7EXQ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="69" mass="7797" checksum="05E8AF689C07A406" modified="2025-10-08" version="1">MTIRCLKSLPSQVKTVFEEEEIESYLSELTQHCRISLENPTLTTGISSFEEVGISHTYLLPRANGRRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXS7</accession>
    <name>A0ABY7EXS7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="66" mass="7584" checksum="BFE40D4F52C9C797" modified="2025-10-08" version="1">MDDDDDDDDDDDDHHHHHLNAPDEDGDSFKDADYTAGSDMDSQDEIVWPKPHTQPTAKKRPIKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZ49</accession>
    <name>A0ABY7EZ49_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GP157-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_005305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF47">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR15200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="311" mass="35641" checksum="9935FC082AA3F6A6" modified="2025-10-08" version="1">MAGTELSNRLDRYLASFIYNESDNITEHSDTLFCTIQSAVTTYSSLVSFFLTVFIALHLFLAVFRPQNSPSGLILLVANIISWGVPGIIIYVALTEKMLGWEANDSPNIGTGSWCWVKCMESDHNKTLFYMCLTEKGFELQCYLYTAALYVLMKLRMDLVYRHNRLHDLQSDLRDDDKNFWLVLLMIRIWGTIRFYLRVFPDTTSDEIERADRVLIYFQAIGDPSQAFCNCILFCILDGDIRAKILGCISCWPSRAQNNNTEETDIDSVSSDYISLFGQNHSGRRRYGSSGILLINRRIVLNAYIKQQGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZ56</accession>
    <name>A0ABY7EZ56_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPRX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_026611</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="43"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR12431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="292" mass="33660" checksum="19E1087F3BDF7AFB" modified="2025-10-08" version="1">MDALPTDKTPRNMTLEELNKEETMYYMGGTILVCSLAVIGLVGNLHVLFVYIWRMKQSNHRIFIICLGVLDLITCLIGMPFIVTNFLKPFTFFDTTMCKTLTFYNFFICLSSACVLIVIAVDRYRKICVPYGKQMSQKVAKAMCLTAMMLALLLSWPGFVIYGSTPIKTRDPDITGYECNILADLKDTWYPIIFNGVLLFIAFSIWITLVTKTPTFILEALTHYVPYLVLRLVFYTNSDWYPSMTFAGKVTFNTFLWCVYVNNMANPIIYGFCDQRFRNEVRIGYNSIFCRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZP1</accession>
    <name>A0ABY7EZP1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_026791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042333">
        <property type="entry name" value="LRAD2/Mig-13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652:SF69">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="35"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR12611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="251" mass="28295" checksum="92C6EF1E4B8623CF" modified="2025-10-08" version="1">MDVQNLLIKFVFVWIAFSCCYLSAAYKYAYMNSVCGQTIYASEETQVELHFSYSLDTCEVTIAKSAQYPNMMLFFESFNIDCSYGNVQLTDDYNYTMGGLDRKLCGFIGPLFEVKTLEGNLHVKYIRTKEKTWGWESFYLNSNDKFTLTVTMYADEESCPSDGHVCGNGRCVSENLRCNSKNSCGDYSGCWTRSNTLVIMWSVMGSVFGFVLIVSVIVISICCRRRSRGFLGQTNAPAPTQPMFTTASAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZW8</accession>
    <name>A0ABY7EZW8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="120" mass="13611" checksum="014B63D59FBCCFC5" modified="2025-10-08" version="1">MSLFKLHIANDQLITSDDQWLLKGVHTQRVFKNVDNKCVSICVSQNDLEFNGECPQTFCDRQCADQRLASRITVVFRSVHKGITVTTPQDNACQLTGGTALWIRMRTKTGTSNHILHKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZX2</accession>
    <name>A0ABY7EZX2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="271" mass="32303" checksum="0A7262F8C3C156FE" modified="2025-10-08" version="1">MTDDPCFWPSGVTCRPWVSYGTYRRRNHSDDDTSRARGRWQTGDLQIGYRNERDARTNSGFKTEQSNTDTRFVNWKTVKPSYIENYKASIEGSKVLINLSSKSPREEEDINAYYREIVTEINAVTKKCIPKAKFKPYIKPYWTKNISLLHKKMTDARSKWILNGRKTHESSNTRKLYKTAKAEFRKAHRYAVPNFIMKLEQEIDETAEMDQNQFWKLINKKRKKVKFDKVFEMNFSGKTCNRPEEINEGWKHYFTDLYSPDETDMERHMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0C1</accession>
    <name>A0ABY7F0C1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="95" mass="11291" checksum="9A6C4399EE63C559" modified="2025-10-08" version="1">MYRFISESDKRNQTLLIAHLNIERTCNGNSYDDVFYLRNTRKITLTCAYDIHFYTWSMYFGQKLSCFAYCCLHQHLEYLCHMLLTPTSASSRKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0G6</accession>
    <name>A0ABY7F0G6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SSPO-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_004348</name>
        <name evidence="4" type="ORF">MAR_005922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF386">
        <property type="entry name" value="HEMOLECTIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFD" evidence="3">
        <location>
            <begin position="23"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ93451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR14243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="364" mass="40118" checksum="9525870ABD1FFCE1" modified="2025-10-08" version="1">MSNISVSTCMEGAWQCTNKRCDKTCSAIGDPHYMTFDGKRYDFMGVCSYYMVHDPGTFDIIVDNIKCGHGGEYSCTKSLSIDISGHHIKMDHNHQLFVDGEEITKTPHENDGIKIFMVSSLFMKAELSNGITILWDGRTRAYITAPPSFINKTQGLCGTYDSNQKNDFKTKEGDIETMPSAFGNRWKTVPTCKDAGPVVNPCETNVNRKNQSAQYCAYLRSDVFQACANTVDVDSFYHDCMFDVCSCTENVKNCLCPILGEYAAQCSAAGVEIHWRTSIPECLLPCDGGQEYQVCPNECTRTCSNIANDQSCVQSSVCAEGCACPADQTLDDYGNCLSISKCPCLFAGNEFLPGITVGRGDQIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0J7</accession>
    <name>A0ABY7F0J7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_005817</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF141">
        <property type="entry name" value="TRANSPOSASE HELIX-TURN-HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR15712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="472" mass="53578" checksum="8ECC49BFADE5ED87" modified="2025-10-08" version="1">MALTCCVKSCSNGSYWLKKWKSQLCDVCGCLHKEKLCSCEPPFRLFTFPTKIKNPERREKWKQLVGRSVGSKLWSPPKDSRICSRHFIGGEPTLQNQLPTLHMGYEGAEKRWNVPPPQQEFFFAEPIYASDPEVESMPKPKLTVPWIFTILALFLGLCNLLSDQKKKIAKLQAEVDSLKKTVNHLKHKVYCENIITTDSDTSFYTGMPSKGIFNKLHAFISPFDLAKRFDISETLCSRIFFSWLRATSTALKSMVYIPDEESLIGSKPLRYRQLHDLHSIIDCTEIFIETPKDMYLQSATWSDYKHHNTLKILVSCAPNSSIVYVSPAYLGRISDKALTLDCGYLDMVPFNKMVMADKGFNISNECAERNITLYVPPGKRGHSQMSSAHVEKTKRIANLRILIEQVIRRLKTFRILANELPISLVGHIDDIVTVCAAVSNLKEPIYKSFNPAANPLKDASSYSAFPVFFPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0S9</accession>
    <name>A0ABY7F0S9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">YMD3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_005885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="5">
        <location>
            <begin position="473"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="738"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR15780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="776" mass="91002" checksum="1437F2E37507693C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1A5</accession>
    <name>A0ABY7F1A5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="111" mass="12910" checksum="741C607D0673EF1F" modified="2025-10-08" version="1">MSKTCIDFCYELLIQPRLVSPSRKQDDIGMDKQLRPHAARISSTSYKEGLRRIRQVYALYDRSASYNAGLRRIRKVNAVKGRTTAYKAVKTKINDDENLNCHYVIISKHKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1P3</accession>
    <name>A0ABY7F1P3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="172" mass="18972" checksum="40B8EAE87EE9D388" modified="2025-10-08" version="1">MERQKRGKEADKNIKGLAMVDNEYKETPCVLVEGAVPLLVENVIQLVKDVEFLPGAVGRKLNQDGTRRGIMDNPTGSVRSINLFNSDIGPNIPTKCHNYLVCTFANFLAKARYAKIVSSAILFTSISFAFQILKNGSSVWLRISWLSFTSGCQEDAKAVTSKSDKHDVCNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2M3</accession>
    <name>A0ABY7F2M3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ANGP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_031041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="327"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR16447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="546" mass="61724" checksum="081227152D85E4AD" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5Y5</accession>
    <name>A0ABY7F5Y5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_031606</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="295"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="468"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR17012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="515" mass="58349" checksum="84055307582455BC" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8B6</accession>
    <name>A0ABY7F8B6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ASATR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_000246</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd14017">
        <property type="entry name" value="STKc_TTBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047916">
        <property type="entry name" value="TTBK_Asator-like_STKc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="374"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="441"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="785"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="848"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1075"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="327"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="854"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="875"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="953"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="963"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1003"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR18408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1097" mass="123064" checksum="A73E3C393FC7521F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8J2</accession>
    <name>A0ABY7F8J2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="13487" checksum="BC8345011C7EC04F" modified="2025-10-08" version="1">MDKQKNIGMYYPTANQDVLKKGTFQVSSSREENRTFYTERTLTIQHKGAGNSTDRSIPHLQFTDWDEMKNIQRSTANFLSFLNVIENVEQFVFCHGCVSEYLRSFEVYANFHEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBV2</accession>
    <name>A0ABY7FBV2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PARP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_000360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR18522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="190" mass="20505" checksum="A4A23ED032ED4D6C" modified="2025-10-08" version="1">MGDHSDLGFKAEYAKSSRASCKACKGGITQDSLRLAIMVQSPMFDGKIPNWFHFKCFWKRARCGGTHEIYGYDGLRWEDQQKIKEQLGGEGGAAGDAGTSGIPVSDFTTEYAKSGAAKCRGCEDKIAKVCVGLIKGFQGLKKEDKDTLIEKLGKGEKSAAGKKRKGEEAQGSGGKKKKQEETAEEKALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBZ8</accession>
    <name>A0ABY7FBZ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="85" mass="9707" checksum="B25AAD4B4A7FBFD1" modified="2025-10-08" version="1">MITSKIKSENKYNDDDDDDDDDDDDDDGDDDDDDDDDDDDDDDDDDDDDDDGGGDDDDDCDNYYYDDDDDDDVDDDEDDDDSDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDT6</accession>
    <name>A0ABY7FDT6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="91" mass="10122" checksum="32DAA6800B7D15C2" modified="2025-10-08" version="1">MNREVLGRYFNDLGTIMEGLNITNKPEDIWNCDEMAKKFEHDPVKVVVEKGSQCLSSSKSTNITIMACVNASGRRMPPIVKGEDGAFSAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FET6</accession>
    <name>A0ABY7FET6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_014662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="214" mass="24509" checksum="7C15F0D0ECB0F666" modified="2025-10-08" version="1">MENRFTFILYDLSIEIQSSINNAVNALISKVIEGINLRLSDEIDSLKTENAHLKARISVVEKSEDRLEHLEQYSRRNGQRISGVCEREGGSTDDIVTKLVSDLGSTVSLDEIDRSYRVGRPRRNDPAKPRDIIVKFMSFRARQKLYVHKPSIAQILRSAWTSDGVILIRDNDMHLHRVTKARELDNFQSVTVPRTSPTSQRPYAYVLNSNVQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJ27</accession>
    <name>A0ABY7FJ27_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_016177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR22203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="51402" checksum="D0B8B26A20D51224" modified="2025-10-08" version="1" fragment="single">KYTNNEVPVSGLNLKIEYNIDWCFTYPFVAAHYQNIPYHNMCPHSRGVVIYVKETIVADYCEILCKADFSESVWCELRLANAKQLLIGGIYKFPSSNLVNQRNLNQLLSQACSLTFDHLVILGDFNFPEIDWSTWTVHRNETHPAFSFVECLRDNFLNQHVQGVTRLITVLTDNQTEVENLTLSSKLSASDHISIICEIPCVVNKDREPVNKGDYVEIRNYLSSVNWKEMADMNVEDFWSFLLRHMNFCVENFIPECNTKGGCKKPKWMDYYCVRKVKKKYHAWKRYTYSRSYRDYQSYCKIRNSTTKAIRFSKKKYQKGVAESSKTSQKSFWSFVKGKTKTRSGIGDLRDKNGNIATEIRQIFTREDNSEIPNFEDKLERENFISDIIVSPQLVLKHLKALNASKACGPDNCHPFFLKQCAEEIYIPLSEIFQKSVSTGILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJY1</accession>
    <name>A0ABY7FJY1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">O-phosphoseryl-tRNA(Sec) selenium transferase</fullName>
            <ecNumber evidence="5 18">2.9.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 18">Selenocysteine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15 18">Selenocysteinyl-tRNA(Sec) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 18">Sep-tRNA:Sec-tRNA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MAR_015143</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">MELC-2E11</strain>
            <tissue evidence="20">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 18">Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>O-phospho-L-seryl-tRNA(Sec) + selenophosphate + H2O = L-selenocysteinyl-tRNA(Sec) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:25041"/>
            <dbReference type="Rhea" id="RHEA-COMP:9743"/>
            <dbReference type="Rhea" id="RHEA-COMP:9947"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78551"/>
            <dbReference type="ChEBI" id="CHEBI:78573"/>
            <dbReference type="EC" id="2.9.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the SepSecS family.</text>
    </comment>
    <dbReference type="EC" id="2.9.1.2" evidence="5 18"/>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019872">
        <property type="entry name" value="Sec-tRNA_Se_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008829">
        <property type="entry name" value="SepSecS/SepCysS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12944:SF2">
        <property type="entry name" value="O-PHOSPHOSERYL-TRNA(SEC) SELENIUM TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12944">
        <property type="entry name" value="SOLUBLE LIVER ANTIGEN/LIVER PANCREAS ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05889">
        <property type="entry name" value="SepSecS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017689">
        <property type="entry name" value="SepSecS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 18" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12 18" id="KW-0711">Selenium</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="389"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="WAR21169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="420" mass="46934" checksum="D2B2066A630D2A2E" modified="2025-10-08" version="1">MTYIFRYKFYTMNAESLSLCEKLVPASYVQQGAQARRMLENKIRIFIQHRKLPDTGWADHEIEILLQELSTMDSNNFPGNCGVGEREGRLYSSLVARRHFRLAHGIGRSGDITAVQPKAAGSISGQLFCCSYGNWDELDVVHAGVPSKETKRQVCLEPVVIENKLEGDELRTDEVAMETKIQELGPENIVCVMTTTSCFAPRAPDRLLEQVVLMCLFSPWIRTSLCQWEAALASAGPSLDLFITLLSMGSAGYRQLLQERKQMYTYLGEQLRLCADRNDLRVLDIKHNPISYAIGLPEATDGKVTELGGMLFTRFVSGARVIEKSDKVTTVSGQSFTNFGAHHDNFPCSNMTVAAAVGITMTDIDTFFTRFDQCLKHFRKTHKTSVIVSQENNGANETRLNEQFQEKSALDSKTGKGEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLE9</accession>
    <name>A0ABY7FLE9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047509419" description="VWFC domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="2">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="103" mass="11387" checksum="814EBAB95057E398" modified="2025-10-08" version="1">MFSTRLLVSVFFFGSMVVLASSLCLNQNNEPMNDGDTYVKNDDPCTSCICQQGTLACMSEMCYLKPCPPGTKLIKIPTECCKRTCKATRGFKAKIVKNINAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FP77</accession>
    <name>A0ABY7FP77_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA:m(4)X modification enzyme TRM13</fullName>
            <ecNumber evidence="12">2.1.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_036496</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43196"/>
            <dbReference type="Rhea" id="RHEA-COMP:10401"/>
            <dbReference type="Rhea" id="RHEA-COMP:10402"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74477"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43192"/>
            <dbReference type="Rhea" id="RHEA-COMP:10399"/>
            <dbReference type="Rhea" id="RHEA-COMP:10400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32767"/>
            <dbReference type="Rhea" id="RHEA-COMP:10397"/>
            <dbReference type="Rhea" id="RHEA-COMP:10398"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the methyltransferase TRM13 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.225" evidence="12"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007871">
        <property type="entry name" value="Methyltransferase_TRM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039044">
        <property type="entry name" value="Trm13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021721">
        <property type="entry name" value="Znf_CCCH-type_TRM13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998:SF0">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05206">
        <property type="entry name" value="TRM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11722">
        <property type="entry name" value="zf-TRM13_CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51800">
        <property type="entry name" value="ZF_CHHC_U11_48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="14">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="47"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="518"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR22827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="612" mass="67401" checksum="A7EDECF0E9790DC6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQ85</accession>
    <name>A0ABY7FQ85_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EGFLA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_036740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF85">
        <property type="entry name" value="SP2353, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="228"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="3">
        <location>
            <begin position="273"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="453"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="3">
        <location>
            <begin position="495"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="671"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="3">
        <location>
            <begin position="697"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR23071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="923" mass="102473" checksum="9FE0884DFF2DAAA4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRY2</accession>
    <name>A0ABY7FRY2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_010684</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR24980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="658"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="699"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="734"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR24980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="877" mass="96029" checksum="373810B00FDF2450" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVV3</accession>
    <name>A0ABY7FVV3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEBP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF1">
        <property type="entry name" value="HEME-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="167" mass="19263" checksum="3D3FA90841F2CF39" modified="2025-10-08" version="1" fragment="single">EYEEREYAATEWVSTQQTNMDYEKASYTMFERLFKYIKGANEKKKPIKMTCPVVNRIIPGAGPACESNFTMSFFVAPIQKPAPAPTDPSVFLNNAPRFTAYVRQFSGYAMTYDVWRDQAVALAKALKVDGVEFRTDMYWTAGYDSPFELFNRHNEVWFLGKNENLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FW06</accession>
    <name>A0ABY7FW06_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NMUR2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_011048</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF233">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR25344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="259" mass="30856" checksum="413CF69F0876A082" modified="2025-10-08" version="1" fragment="single">KLVPFLENTVANVSILTIVAISIERYKVIRHPLQSINEHTAKVWVRNTITWVVSLVFCIPWIYVVDFREYSTREGRQIQVCRSPINENWKRVYILLMSSCFFILPAVALLVINWHMFCLLRRNCHQFVTSGNKREYERRQKQVANNVASIVVIFFLCHLPFRVSGLWFTFAPIPEIRRLGLENILLLIYLSRVLFYLNHAINPLVYNFVSSKFRESFKEVWVNVKCCRLFRRRHYFYTSRSYWYTGRTATTGNQMQSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWB0</accession>
    <name>A0ABY7FWB0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_010830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="337" mass="37998" checksum="A0D12CA5957E9AF6" modified="2025-10-08" version="1">MCLYFTLYIKMYAREGIKLWTSCSHSGRFIGRQFFLLLNFVLFAARANDAGEPEILMEGECKQNIGPGTSVTITHVGTKCLFYKPNHRCPIITIDDSLGADIEYHQATDGDSFSAGITLRKVFMRCNPYIQVEGTVDSMLSDKTRLCLKVNFTEDQLEGDRWGEYKDIALNCRLKFRAITYVVLRFYYLLNPCTSSSDDPQLFCKTFEAVRTTPLSAPPSSTSSATTSSTPSANSSFSFDYVPIAVVALILFTSVVVAMVIWYRARCSTTETQRGYRGHTRGLDTLCCLRQQATDQLRNNSRQETEMIEVMPELNGNEPDYRGRCPIERVDCCITSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXD4</accession>
    <name>A0ABY7FXD4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7789 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_012544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056691">
        <property type="entry name" value="DUF7789"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39299">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39299:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25044">
        <property type="entry name" value="DUF7789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7789" evidence="2">
        <location>
            <begin position="28"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR26840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="85" mass="9657" checksum="B0619C39224D27BC" modified="2025-10-08" version="1">MAEEDNESGDYTRFGIPDTPRSTVTTVIGKTRTWAGLQWKEKLFLVFSLVNILAAIGLTTYRLVDVARTDTNNKDFTFTILIIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYW9</accession>
    <name>A0ABY7FYW9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GST3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="86"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR26108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="211" mass="23800" checksum="F187EFA24E4D8725" modified="2025-10-08" version="1">MGEIYKLKYFKSKGNAEIIRMVFSAAGQKFEDERMDREQWLKIKPDSPFGGMPILSITKGKTETSYCQTGAIARTLARKFKLAGANEEEQLLVEEVFECVMDTQKAIIGLFSDKNDDAAKAAIKDEFVKESIPKLAKYVELRSGKGKNGYIVGSALSLADLAVFNFVDQTGGLGLVDAWNKYPVIKKHQEKVKSEKKVAEWLKKRQEYEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYZ1</accession>
    <name>A0ABY7FYZ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ZO71-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_013134</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF216">
        <property type="entry name" value="ZINC FINGER PROTEIN 420-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="488"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="642"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="675"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="703"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR27430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="788" mass="88787" checksum="B3D60FAC756FA394" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZ17</accession>
    <name>A0ABY7FZ17_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SC5A8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_011775</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF2">
        <property type="entry name" value="SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR26071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="129" mass="14749" checksum="700BD06C5FA679D6" modified="2025-10-08" version="1">MAFENRLQTADLIVLVVGILVSLFTGIFYSYKERKHVSSYFYHRGGGKLSAIPVAMSMLVTFESSIFFLGYPSEVYIHGFIYCWINIGIAIGNRGPDGFQMPLPWRIRLMRSENLLAKFTDVSTDRERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G039</accession>
    <name>A0ABY7G039_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_013289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR27585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="217" mass="24750" checksum="752E3DD56905EAE1" modified="2025-10-08" version="1" fragment="single">MSYLGWRSRRGKVKSYNNTAELCFNLGLCYPPDACQINGFIQAYKASAKINLKVGYFKEATNCYTKALQGYELCHNDPTVAIKRHKLLCKRSSAYLGMKKFKESRRDAAQAVDLCPSDIKGYWRYSEAVKGGYHGVQLAMPYLTEGLRRALDVNTVKQNDVVKFITEICALIPEAPRTEKMRRILYDMCIPDEKDVQIWYKVIANLAAGRHWKGLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1M9</accession>
    <name>A0ABY7G1M9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_012896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR27192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046998296" description="EGF-like domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR27192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="16626" checksum="8216A6B01EE852B9" modified="2025-10-08" version="1">MVLANKNKMDLLCILLPTIVFFGASAQAASETCTVQHTTVLPQTTTASAGSTSTQGTTSPTAETTKQTTETTVTTIPSTVSIPATTAPTGGSGRRKRQTSTDECVANAHCLMVGGQLKCSCIQGHTADGDGFCQQDNAAGSQYKASTRIAFGAAILLMMMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3I8</accession>
    <name>A0ABY7G3I8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MYO5A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_002568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd15470">
        <property type="entry name" value="Myo5_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dilute" evidence="2">
        <location>
            <begin position="255"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR29000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="532" mass="60915" checksum="23720C9A72792E1D" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5K1</accession>
    <name>A0ABY7G5K1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_014333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038875">
        <property type="entry name" value="PLA2_conodipine-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37687">
        <property type="entry name" value="AGAP006772-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37687:SF1">
        <property type="entry name" value="AGAP006772-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046565743" evidence="3">
        <location>
            <begin position="23"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR28629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="597" mass="66864" checksum="DB8E33E344BD2FF6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5T4</accession>
    <name>A0ABY7G5T4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="76" mass="8443" checksum="09BCB6F9245E7A24" modified="2025-10-08" version="1" fragment="single">FVLGRWSRILKISYKGSIGKETDESDRPSLKPMGAEQLAIPDDVDIDQASSNSATDQPVHDYADDLHGKKLLILYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G666</accession>
    <name>A0ABY7G666_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="201" mass="22766" checksum="93538088F45EF915" modified="2025-10-08" version="1">MAGSTRRLLGGGQMLSQYIRLLGQNGVRDIRNKTLHDANYELDGQKADDCLDKMITVLEDPQELIHDTFAKPAANQIRKIKAKTEETPAILTNLYDLRQRLAKYYLKQLNSAPISLLLSDNDEKLDKLYAPPKIVEKDSRKVGAVSKENGTHVTAYRQLLCKIGKFRKKRVHCRRGRDGKVILHGNMCNKMGQSDLINGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8N6</accession>
    <name>A0ABY7G8N6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35378:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35378">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="179" mass="20764" checksum="F7F8460C287E8036" modified="2025-10-08" version="1">MELKPSEIYYSQDSISNAFRHTYELIGETLDDICEDRCSIYSIPTISVMRKNGRWITSDNRRLWVFRQLERLGKCDTVPVYVTDQIPPEKMTSLNGGDAVRVRGNPGGSWHLKPKPVVNQRYTSYPRYSVQPKPKPVVYPTPESVYTPRRETNYGTEAMHTQYRPVQEENSERSLCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GB92</accession>
    <name>A0ABY7GB92_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LRP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_032783</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052080">
        <property type="entry name" value="vWF_C/EGF_Fibrillin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333:SF4">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333">
        <property type="entry name" value="VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR30241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="152" mass="16854" checksum="CB58984FF8BA12B8" modified="2025-10-08" version="1">MFKPCSQICTDKKMGYECSCYHGYSLKTDGKTCQDVDECSTEFPCAHFCQNAQGTYFCTCAEGFSLVGDRRGCNYTNSMSADEQTSNNSKVTTVSAIIQTNNERSNIYLLVILPAVGCSLGLCLVVFVGLLCCKRTGRLCFSHRQQKAKKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBN0</accession>
    <name>A0ABY7GBN0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZN862-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF5">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="392"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="473" mass="52558" checksum="D8F72157D2C8D6FC" modified="2025-10-08" version="1">MIDETTDIATHSQLSIYVRYLHQGASKTVFCSLVKVHNGKSDTIRAAVVQFLRDAELPLNKMCAFGSDGAAAMLGKKNGVAAQLQTMVPHILVNHCVAHRLALASSQAAEKVPYLLKWKAIVEQLFRFYHASGVRTASLLEIQTILEEPKVKVTEAKDVRWLSHNKAVKAIRRCLPSLLTSLEHEARERCDAVAQGLAIFMQQYRFVAALMMMSDVLPVLANLSLALQTKDAVYSTVGTLVMGAITTVRSMKEHPELNFRELPVTIGQLSGQPFRFKKPSANDVSDFKSNVFDKFIDAVVNNLESRFPHIPVLEAFSMFNPTTVPEDQAERNDHCKDELQMLVERFTAVLPDATEAASEYSVLKNTIHQDLGLQKTSTTVLMEKVAGPLKEAMPNLRLLAAVGLLLPTSTADCERGFSTLKRVKTAQRNRLQNEALNAVLRVSMEGPSVADFTKTEAEKMVSEWAREKRRLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBU8</accession>
    <name>A0ABY7GBU8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="1">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="199" mass="22040" checksum="D6E5DA7E806716F3" modified="2025-10-08" version="1">MTPLKLMYPDSVFDTKVVQSRGGIASETKDLWIKINDAYNEDSHHPRTAAELTKKWDNLVQTHRAKYSQYKRELGRTGSGTNPVKLSEVTERVMAVVGENSPNIVGLCSGLDSTILQMQSSNCSAVETPSQPSHTIELYEEPLQPVQDISTSYIVNCSGSSSSNNTNNNGCSHCSTCMEIMALKKRKLQLEVQLLEKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GCY6</accession>
    <name>A0ABY7GCY6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="198" mass="22185" checksum="7CE520E33E973314" modified="2025-10-08" version="1">MERRQFLGNSEVSRSSVSVECVDYEIRHILCFALDASFDGQHQTEPSQGCTDSFKRESPVFNDPALICLSLHTVLPGNAVSKREIFLNCIITELCDVFVYSGNSDVHNGPAHYYEDIAPSSNIGNSDVHNGPAHIMWTLPRVQTLELSTIQGSDKEHLEAKPQLWKLVYRSASGYRNAIPSWIKRLLSSKTNVYIEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GDF7</accession>
    <name>A0ABY7GDF7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DOK1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_002799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050996">
        <property type="entry name" value="Docking_Protein_DOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258">
        <property type="entry name" value="DOCKING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258:SF62">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="IRS-type PTB" evidence="3">
        <location>
            <begin position="84"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR29231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="194" mass="22152" checksum="CE37C69D1904B577" modified="2025-10-08" version="1">MANENLSRDMEISYCYKCALRKIKVGGAFYCQECSKRLCKDCAALHTAKKRHRGHEIREIMEYPKSPMTLADKDEIGSLINSPTGYNFIVDIASTPLAEKCKVVGKKILFIHVRGITVKEPSTGNGVFTYQLTWIRRYGNKSGIFYFEVGRKCPHSEGNIEMRCKDEKTAKVIQKSVLKCTQLYEHKKSKDKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAA9</accession>
    <name>A0ABY7DAA9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ZSC22-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_006487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ94016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="457" mass="52102" checksum="BEE510365D72F867" modified="2025-10-08" version="1">MAHTSQRNGLRTSVKKVNYRKLHEFGRNRKEDVSTAEDLGQQLVPDDNISSLKNRHSDMFVCGICSKSFSNFNQYLEHFEDHNIFLDVDRHTCIKQESKITCTRCEQQFLTPCSLHEHCKDHGLDGTYIFDGLSNTAFPLGHECAKDDTRLADDADMVNAFSELVQEDKDGFVLKAYSSFLKYVSNKMKHIAEISVPVSEAQCENRTKIHGNNISTFNSKPDKKNLSFGNEIQGNKYSNSVGNVIEDTKPCTFTNSEKDCNTCSLQNEEHKNIVIKYEQKEGDDNYETGDHVLEVDDENVQTCNSSKDVVQSVSKGRRKIMKKEKTPVVKFEMKGRPKRMKAGLENLKNKHGKNRIMKIVNGQRYYECGICGKHVRNSIHDHKRIHTGERPFECSICGKKFSRKGHVKQHALTHLTIKPIYCDQCGKGFTTNTESNKGLGINSDNFANAIPWYQPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAS9</accession>
    <name>A0ABY7DAS9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FER-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_006182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="242"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ93711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="452" mass="51280" checksum="C9008121E22965F9" modified="2025-10-08" version="1">MSSDIDHEKCDKHGSEYVFFCKKHANVGCGRCLLKEHVTCGQNIVDLDDITKENVDTQLVNNLKSSMEDMSDYILQIEENLSGSQSRNNTSKEACLRELNAYKKRIEDRIEKQTKNAKDAVTDMYNRGEEDIKIVSAACCELKQKITSKKTDFDASICNEQYKKQFILMTTLTEELETLTPEVEEMKQRSITEPITLVCNIDENTSMPPPLSPRPTRYDPALECSSDIDDKPDCGEIRLDDIVSCVLIGQGHFNNFAEVFKGFCKPMNVKRQAFATHMTALRTLDHPNLVKYLGIVLESQPVRIVMEYVSGTVAIRIGLESQAIRIVIEYGQCLLDYLRSIDNKQTTIEAAGMCLDIATGMEYLIAHGCLHKTLAARNCFITNDCVVKISDYGIYSVATKEFLPAPRITPDSIYHLMKRCCASDSKERFLFTDILRQLRRLIKNPPSTEKWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBF1</accession>
    <name>A0ABY7DBF1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CO8A2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_007115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF64">
        <property type="entry name" value="C1Q-RELATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045229306" evidence="4">
        <location>
            <begin position="21"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="75"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ94644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="211" mass="23512" checksum="3B15CFD07962D652" modified="2025-10-08" version="1">MNPVFIGALLAVCLINDVHGKAIPWDQQHLALLSKVEELERIVNKMRQHQSLEIRTDKDDLSRQARQAELSNVRYDGGESGFYVTLDKPQEVETKMPLKFDDVVTDIGGAYDKQTGIYTAPVTGTYMFALNAVCAARNFLHLAIYKNNAPAFKVICDDLKGEIQHQGGGTTILRLQRGDRIYVTMMFPLGTVGEVRGNGMTSFSGYLLKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCJ0</accession>
    <name>A0ABY7DCJ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MRJP3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_007484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF18">
        <property type="entry name" value="PROTEIN YELLOW-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046840858" evidence="4">
        <location>
            <begin position="22"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ95013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="437" mass="49024" checksum="A897285E6AEFD20D" modified="2025-10-08" version="1">MGQFTVCVVLFCVCALQGVHSDEHGAKVVYQWNIVEYEWPNNTIKDQKIASGAYQPRNSAINGIKLYKNDIYVTVPRLMPGVPSTLNVVVKNESDFPILRPFPSWEMQELENCEALQRVQSMEIDPHMGHMWIIDTGYRANMSDIAINPLGKCPPKLIIYDLNKRQEVHRYIFPPTVAGTGLFYLNDIVLGFADGKARYAFISDTLAYKLVVYDYVENTSYAYSHPTMVADRQYMNITIGNDTITAITGINGIAMSPDFKYVYYSSVAGVGLHQIKTSVIVNAKGDNAAFAANVRTLGEKVAPGDGLAYGSNHNLYYSALGPNAIFKWEVGKDAGSERDFDNVKLTSHSELVSDSRMQWVDTMSIDEQGYLWYTTSRLNKLFSEAGVQHTEPNFFIWKIYVGERNYMYDRHGATQGAAGTVMSLTSMLICVCMAYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIC9</accession>
    <name>A0ABY7DIC9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ARL16-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_029155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46688">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46688:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ96465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="177" mass="19314" checksum="E29EF69394C4780A" modified="2025-10-08" version="1">MTLLLGATGAGKTLLLKRLEIAPHISKNGTDLHFEEMPPTIPTVGTNLVTVSVGRRQEITVREVGGCMGPIWKNYLKDAHNLLYVIDVADRLQVAASCVQLLSVLAAESLPLIPVLIVFNKIDMPDRMSPSEIESLFRLKDIAHCCGRKFDTVEVSSCSGKGLGEIISWMDKNTIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIG3</accession>
    <name>A0ABY7DIG3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AT2L1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_028820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF13">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ96130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="492" mass="54807" checksum="EADD3E38BDEC63D1" modified="2025-10-08" version="1">MKLYETSFVAVSLKMIEWFRMKRSDKSNTVKKAIMPEKPNTLTFKQTLKMRRNYVGRSCKLHYEVAPLKIVRGSKQYLYDDSGNEYLDCVNNISHVGHCHPHVVNAGQEQMSKLMTCFGFLSDLQVAYAKRIVEMLPENLCVCYFLNSGAYHGNTENLIKISPSRLKQHNMPIDDWVHVVPCPDVYRGKYREDNVSPGHLYANEVKVAIAKALDKGRTISAFICEPVMTSAGTVVPPANFFKLVYRYVREAGGVCIADEVQTGLGRCGEAYWAFESHDVVPDIITLGKPMGNGHPMSMVVTTKEISDSLKEFSSAYGGNPVACAMGMAVLDVIRNEHLLSSAKSVGKCLKDGFQAILQKHRLMGDVRGAGMLVGVEIVEDKESRKPNKDAAEALVYKLKEKKIITSNEGPDKNVIIFQPPMCFTCENAATVVKAVDDALTEVEEEDRQVSMSSDIIVPLSVITASKHKLSSDDEDDDDEYESPSKRFYEGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJ73</accession>
    <name>A0ABY7DJ73_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_022112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ97739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="192" mass="21750" checksum="B613DB0D64B75932" modified="2025-10-08" version="1" fragment="single">VHYLEVFSLLATNHLTISSVAFIFVRSLKTGENTDVNVELLNTDVNAEFLNTDVNLEILNTDVNAELLNTDVNAEFLNTDVNVEILNTDVNVKILNTDVNVEILNTDVNVELLNTAVNVEILNTDVNLEILNTDVNVEILSTDLYKPSDYISCMRHENRKQNNYNVLYLLDIRTRTFFICLGLILENQDTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKL5</accession>
    <name>A0ABY7DKL5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GATOR complex protein NPRL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nitrogen permease regulator 3-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_030123</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NPR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="3">
        <location>
            <begin position="448"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ97433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="517" mass="58376" checksum="96F9484965DD7BC6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLL9</accession>
    <name>A0ABY7DLL9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHF5A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="102" mass="11485" checksum="BB69F31E55D63038" modified="2025-10-08" version="1">MAKHHPDLIFCRKQPGVGDGKCVICDSYVRPSTLVRICDECNYGSYQGRCVICGGPGVSDAYYCKECTIMEKDRDGCPKIVNLGSAKTDLFYERKKYGFKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNW1</accession>
    <name>A0ABY7DNW1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_023764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ99391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="216" mass="24388" checksum="EC4FF58CC583C6EE" modified="2025-10-08" version="1">MAKSNDFLDNMINNCDSAENFNVECIDHYDNDRDGYLNFQECCSLLEDVCKSTTYKLSREYKDRIFNLLDEDKNDFISGSLSLLGCPAGHDGAEVIPVINHLLDSVPFDLVVYTKDWHPENHISFVENVQNRPLAKNCKHSGITTNSHKPTLYESLRDTKSLMCYTALHALEHGFRTVLVDDACKGVDAKGIEETKRKLVDSGGIIVHSSQREENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQF9</accession>
    <name>A0ABY7DQF9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FOXL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_023501</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd20035">
        <property type="entry name" value="FH_FOXQ2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047519">
        <property type="entry name" value="FH_FOXQ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF142">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="103"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="103"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ99128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="342" mass="38093" checksum="FBC8F13C1F3B3ED4" modified="2025-10-08" version="1">MSLFSNDYLTTASAYQSSGYQCIQGGMYYGAASPLSEDGYCSANGSSVVTERQTSSPADSGMESDRSPGNTKTAEREDRDLAEVLADLEKKTSHVARGEADFKPNHSYIALISMAIMSTSDQKMLLSDIYQYIMDNFEFYNNEEKPWRNSIRHNLSLNECFIKAGRSDNGKGNYWMIHPACVEDFAKGDFRRRQARRRARKSTKDVNESVAARSPYDYNGGYLHMASSYNAYHPYSHQASMYYPMTSSISNSTSQNDHDNYLAANYLSDISGSNNSTTQQFYAEQTMLTSGQHMSVADNQHLAEHSAGAAVTVQALAQQQAAIASTLQFQNWLQSSITRNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQT6</accession>
    <name>A0ABY7DQT6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DMBT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_023624</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055356">
        <property type="entry name" value="ZP-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF43">
        <property type="entry name" value="DELTA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23344">
        <property type="entry name" value="ZP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ99251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="236" mass="27015" checksum="E0FF152B49ED150D" modified="2025-10-08" version="1">MFCKKAPEGEIRYGRGWDIQVDMNRLRMASSGALASDIYLGDNSCTGTEEWGVLHFRQGLQQCLTSETMRNNTLVYSNELVYAEHDPVYSFIIRRHIHHNNDQHTVVPVEDARQYDVNVTFYRDANFQMPLPGNQLHVPVGTYVFVKMYTTTSDWTVTIRLDSCYTRLANSSLNNLQYFLIKNGCAMDSNTHLISQSAHETRFVFKDFDYTNSHEGIDVTCDATFCSASDVSRQCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRD6</accession>
    <name>A0ABY7DRD6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CCD22-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_023512</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008530">
        <property type="entry name" value="CCDC22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048348">
        <property type="entry name" value="CCDC22_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048349">
        <property type="entry name" value="CCDC22_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15668:SF4">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15668">
        <property type="entry name" value="JM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05667">
        <property type="entry name" value="CCDC22_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21674">
        <property type="entry name" value="CCDC22_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC22 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="CCDC22 coiled-coil" evidence="4">
        <location>
            <begin position="398"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="319"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ99139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="542" mass="61140" checksum="FEBD508014B07AAC" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSY9</accession>
    <name>A0ABY7DSY9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="537" mass="58990" checksum="7BD0DBE3B46607A0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTR8</accession>
    <name>A0ABY7DTR8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="101" mass="11701" checksum="5B9D380E360C7F33" modified="2025-10-08" version="1">MKRVDSEYEYSQVRTKISEWEITLKACKMAALTDGNRESEIFNHPGSKTKSYVWKVFGFQKIALNLSPTKDNLNMNIAICRLCKKTYKNTVKQLLSSNIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTW9</accession>
    <name>A0ABY7DTW9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46104:SF1">
        <property type="entry name" value="GENE 9195-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46104">
        <property type="entry name" value="GENE 9195-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="79" mass="8205" checksum="9B223ED206C0E3BC" modified="2025-10-08" version="1" fragment="single">MGLECWPGHYCEQGSPIPVFCPNGTFQPSSAQSTCLTCDPGFYCNLAAGVAITTPANCTMGYYCPAGSSLPTPCPVGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DW25</accession>
    <name>A0ABY7DW25_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABCB9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_008483</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF19">
        <property type="entry name" value="ABC TRANSPORTER B FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="126"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="425"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR01925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="646" mass="71392" checksum="E54FC0FB49C411EB" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWJ4</accession>
    <name>A0ABY7DWJ4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_007832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="1"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="2">
        <location>
            <begin position="18"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="2">
        <location>
            <begin position="181"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR01274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="230" mass="25410" checksum="E27A9F21B4A18723" modified="2025-10-08" version="1">MSSVPSIPEFYAGRSIFITGATGFLGKILVEKLLRSCPDVKCVYLLIRPKKGKETQERLEEILESKLFGKVKADNPDFRSKCKAIEGDIIKEGLGIDQSDLDILSKEVSVVFHSAATIKFDEEMKLSAEMNVSGVKSMLEICKKLPNLASFTHISTAYANCDQEKITEDIYDPPLKPDQLLTEYLIKQEAGSLPVAIFRPSIVGATYQEPFRGWVDNVNGPTGLLAAVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWT6</accession>
    <name>A0ABY7DWT6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AB14G-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_007922</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF63">
        <property type="entry name" value="EARLY GENE AT 23, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR01364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="101" mass="10969" checksum="F04DB657E21293AF" modified="2025-10-08" version="1" fragment="single">MNTLSKDTILALKSVCFSTKRNTILDDVTCTAQSGDILAIMGPSGAGKTTLLNVISGRQKLTSGEITLSGVQFGKQLRRRLGFVLQSDVLFSNLTLWETLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXB1</accession>
    <name>A0ABY7DXB1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WLS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_008087</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wntless family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047843">
        <property type="entry name" value="WLS-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053936">
        <property type="entry name" value="WLS_GOLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009551">
        <property type="entry name" value="Wntless"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13449">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13449:SF2">
        <property type="entry name" value="PROTEIN WNTLESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06664">
        <property type="entry name" value="WLS-like_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21883">
        <property type="entry name" value="WLS_GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless GOLD" evidence="11">
        <location>
            <begin position="48"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless-like transmembrane" evidence="10">
        <location>
            <begin position="167"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR01529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="453" mass="51826" checksum="96DDF28A84F0C067" modified="2025-10-08" version="1">MAGVVLETLSWKKLIILGISLLLLLIAFFLIGGLVAPNPSNFVYVTGTTCIDDSGSRNSSEWFIPRGGVEKCTQVDTFEDPYIRDHHVVFSFWLPHLREGKQLDFSPWQQYMIAVLQVDISYNEDIPLAEDAILTLDARIGYREKTDGKNDWKELARIPTDPAIHQNGGFTKVWISIKSVMFPLIIAVMIWFWRRIQQLTRQPNLLERTLLALGIAMSVLNCPLEYFSLAFDMPYMLLLTDIRQGYFYAMLLSFWIIFTGEHIMDTTERNRLVVYWKHLLAVIIGCFCLLLFELSERGVQLVNPFFSIWVTDLGARLALSFIIIAAISAAGYFFFLCYMIFLVFRNISAKRTALPSMTSGRRLYYLGLIYRFKFLMLVTLVCSALTVVFFILSQLSEGQWQWMEQSPALHYTSAFFTGVSDENSREEEVQLTYLPSNSEGSAIQAFASKAAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYE9</accession>
    <name>A0ABY7DYE9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PRP8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_008259</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="7">
        <location>
            <begin position="1881"/>
            <end position="2001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR01701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2103" mass="245479" checksum="80E6E8E1F14C7366" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYY9</accession>
    <name>A0ABY7DYY9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_008059</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045191">
        <property type="entry name" value="MBR1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937:SF65">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ARK2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="254"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR01501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="418" mass="46694" checksum="04F4BA0CB1B507DD" modified="2025-10-08" version="1">MHSCTCRLRGSDRRSNDSELIGRANSARNTGACGIQQQENVGGFYGRESPVIQNSGLTEGFLANDRYAQAGNTSPQPSTSGLVGNRPPRRRQDLSSRATVVVDLTEGDCDDPSILATAGAPNSLTPTFDLDLHPDNRDLDQQLEESSRRHLPEREQWKISLPCTQPLDSTSPLITAKRGPSSHLSTLQYAKITKHYPPISAVFPVPAPHPHQHQQLPPHQDNLRMLDLLRAQFQHAQLVQGSNLLQIPPHSLVETQPPMAHSQTSCSLDSAPRPPANNQHPQSTPQGQHQHLHHHLHHYHHAGVPRLRHFAAVPGVHHGRPFPEFPAVPDFQTFPPVPPSFGMLPRNVQMRLQLGRMMFNPHRPPTYEELLHLEERLGNVNRGASQDVKIINEDEEDDSNHMEKCTICLSEFENDEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZF7</accession>
    <name>A0ABY7DZF7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047194691" evidence="1">
        <location>
            <begin position="22"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="189" mass="21086" checksum="7D2CF389A1C5BAD9" modified="2025-10-08" version="1">MSFAGLAVVVSAALMAFRGLAHNGGWEAGRVMVGDVVPRARGPEMDRVFLSIGYTQRTFLDVSAREISPANSCNTILALLSDDAQIPYGHRSLLKASYGFYELVDDSMKMFCRVPRFSPALRNFRGRGHRAETMRTPFERRTYTRASHEVRLSSARLVCDVSTDTLRLHLPSYDIVRAQSGVQRKTGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZH1</accession>
    <name>A0ABY7DZH1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein kinase greatwall</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Microtubule-associated serine/threonine-protein kinase-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_008897</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="27"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="700"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="1008"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="245"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="621"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="688"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="688"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR02339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1075" mass="119999" checksum="0539637AC8F959EE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1N1</accession>
    <name>A0ABY7E1N1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MLRP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_009672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="65"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="5">
        <location>
            <begin position="127"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="452"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="293"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR03114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="558" mass="61862" checksum="0E05D726F8EA563D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2H6</accession>
    <name>A0ABY7E2H6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FRRS1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_009695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23130">
        <property type="entry name" value="CYTOCHROME B561 AND DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23130:SF171">
        <property type="entry name" value="OS01G0895300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045189945" evidence="6">
        <location>
            <begin position="33"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="7">
        <location>
            <begin position="57"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR03137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="396" mass="42890" checksum="1F3854F18F55FF1E" modified="2025-10-08" version="1">MRIYMMWPNSGYVLVKALILGIVSSNLNSVCAQTISKPSSCGDSTGCFHNGCTSDDCEFLLKWQDGGGDDLDLTLTCIGTGDKYCAIGLSSDSKMASASVIECVSTSSTPAVYVSYNTGYSNSRLSQNQLGLTLTSSSHTNGIFTCTFKRKKTATLASASVADSTKYFDMNSDWTLLYAYGSSSGGSIQQHSSNPCASLETADFQSSDDVGCSATDRPLVKLHGILMSLVWMLFAHVGVFMASINKQTWPDSTLWFGLKPWFVPIMAAFRPKPDHPRRIIFRIAHTLVGYLAIILATVNLYTGASLSAANAPASTRIVLIVFNVWIVVVPIAAFLYLAFSRKPKQNKSNEVELEPYDSGQETKEPLDNVRVLITAVYVVGLLALSIAFWVLFAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2W7</accession>
    <name>A0ABY7E2W7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S23A1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_009849</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11119">
        <property type="entry name" value="XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR03291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="511" mass="55966" checksum="8F3F15CFDFE197E3" modified="2025-10-08" version="1">MQSAILSGLQYKVDDNPPWISTILLGFQHYLMLLSSNLATPGLMASIICAVNIPEAMHVRSVLLGNMIFACGVCTLLQTFLGARLPIVQCPAFAYIVPMLALVKIPRWSCPAAAEEGLVNITANGSQLADGAVSSDHVERMNQLTGSIMVAALLEILIGASGLVSVLLKFIGPLTVAPTIMLMGLSVAETGFDLSGKHWGISAATIILIILFSEIIPIFEFSNPFSKNKDQKIQFVLHKLFSVILSTCIMWFVCYILTATGALPEEGHYGYEARTDIRLDVINEVAWVRFPYPGYWGTPTFNSGFFIAMIAGVVTSVIESIGDYYTCARLAGALPPPTHAVNRGVLAAVGASNLQYVDLNSSRNLVVFGISLFLGLSFPNWVTANEQLIRTGNENLDQVIQALLANNMFMGCFSALVLDNVIPGTDEERGIIIWREVPEDTDEDSDDNQDNNLTMKTYDLPFGMNLIRSLRWGKYVPFFPTFEGFNDLRCCPCKKDQPDLDEVDVVVKNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4G0</accession>
    <name>A0ABY7E4G0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IFT20-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_010415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028172">
        <property type="entry name" value="FT20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31978">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31978:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14931">
        <property type="entry name" value="IFT20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="79"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR03857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="132" mass="15467" checksum="887C1539690A397C" modified="2025-10-08" version="1">MADEALSRAGLHFDELNKIRVLEPEVQQQTSELKEECKDFVDKIGDFQKIVGTFIEVVDNVSKEVEKEKMKAIGSRNLLKSIAKQREAQQQQLQALIAERKMQLERLRIQYENLQKEESEQSEFIEQFILQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E599</accession>
    <name>A0ABY7E599_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="2">2.5.1.114</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_008879</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.5.1.114"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.114" evidence="2"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF25">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="8">
        <location>
            <begin position="118"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR02321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="608" mass="67859" checksum="4A4A12697D98381A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E665</accession>
    <name>A0ABY7E665_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_019656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR04287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="525" mass="57273" checksum="74AF41D69ABF2507" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6I5</accession>
    <name>A0ABY7E6I5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="102" mass="11127" checksum="451F051E2D2842BB" modified="2025-10-08" version="1">MTYGKRDDEQRRDKTRHSGRRQVREDGDDVTSGHCELEITCKGDTTSRTPVRLPIRGPRGPAGRPGEKGPPGEPGIPGTPGAPGQRQNTHTYKDTMAEPVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6L6</accession>
    <name>A0ABY7E6L6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="78" mass="8869" checksum="05125749A1F76946" modified="2025-10-08" version="1">MAAQEEKKRNPNFSKEECALLVKLMGDESGQYMSRHALYKKGFSSNFIRKMFLQLVVPGQLQLAPVKCSCALIWFANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E765</accession>
    <name>A0ABY7E765_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_020408</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052598">
        <property type="entry name" value="IgSF_CEA-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337:SF8">
        <property type="entry name" value="IMMUNOGLOBULIN SUBTYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046329929" description="Ig-like domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="26"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR05039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="426" mass="47661" checksum="B433A88E3FF416D4" modified="2025-10-08" version="1">MDRSHRYHLKGVLLVVMLGTSTASPPSVSVHLDSDPNPLLGNSVVIECEADDFDGNDVVFKWTFRNMQIENMSSRGKYMEELDSYYSHLTIHDIGHADLGQYECFASSSANGQLSDKYNLNFDFNPSLYMSKRQAKIGDDVTMVCRHNPNQGDWKFENRRGNVISSAEYFKRFVNHVTSFVAPVYMKNITLHNVTLEQSGNYICFNTRGQPKEDTTTLEVNGMTINCHSQNNEDMILTEGVDDTIVCTVQANPAIERDADVGLWWSPTVGSAEFEKIPNDVCNVGMEPGPPLTTWTLTIDVKGKYVYRLINKRIKIQIKDQYVYINIQIQQPCQPPCWPNMKCDMKKQCSCTPGFRPNPVGIGTGCIPEGNEIAYAKPQIAAIAGGVTAGVITMVVCVVVFCVLRNQYSCAFKVTRKEGSRSRPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EA31</accession>
    <name>A0ABY7EA31_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751">
        <property type="entry name" value="SI:CH211-108C17.2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751:SF7">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="278" mass="32765" checksum="FC8AA594D42A5707" modified="2025-10-08" version="1">MDNETKKVIILKTVDKRETDRKSVAMEKVALKACLEDLLQNQVNITELIVLKKEHSVLRPWVKDIVNHFWHCCKVAQTIKEFVDGYYECSRGPLNPEERNKPWLNKKENCSTLEALTAIVLDKHLLSKIANYLNSRSTADLEGFNQHILMYCSKWFSYSPPVYRMRNLIAAIDHNNHLEREFQHNKDGSVRLNRVWNKKSGRWAVYPVKEKKTFLYIESLKKQILMCRLTDNVGMSRRAVMEEQDPRRISSHLGPLSPKPSRELYRELYSEQESRFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EB55</accession>
    <name>A0ABY7EB55_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="239" mass="27482" checksum="5D55D7F283072B75" modified="2025-10-08" version="1">MAPLTLIKPSYVNRPVTLKMEPRDEWMGGVVWKFLQPGSAEFRVANNQNDIPQNSVIVGPQFGDFFKTKCVYADTGIDIFCRTDFGIKPLNISIKVGRQFLPLVVEEFGTGPTIRDPSCFYGDNLTATCEVNDALPVPMIEIRLDEKKLKVQQHDEYERFKNTFSSKTTLTTVDKEWNGTEMCCTSKIGNNMNGRYAEKRWNITVRSLLAANYLWKFDIYWYINNNPCLLFTKETSTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EE21</accession>
    <name>A0ABY7EE21_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="152" mass="17512" checksum="04535DCB607EF76A" modified="2025-10-08" version="1">MRLPSMEAFFPHLTRSRLMRLRMATYSAESDILPSVHRTLNQTDAAHERAPDRTALITFDRSQTRDESNALLCDDDHNDDDADDDDDDDDDDGGDDDDDDDDDDDDDDDDDDEDDEDEDDEDDEDDDEDDDEDDEDSIRVGYILDVNQCYFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEA0</accession>
    <name>A0ABY7EEA0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="627" mass="68857" checksum="539AB33E44CFF6A3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EF88</accession>
    <name>A0ABY7EF88_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CK5P1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_017414</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00089">
        <property type="entry name" value="MiaB/RimO family radical SAM methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020:SF2">
        <property type="entry name" value="MITOCHONDRIAL TRNA METHYLTHIOTRANSFERASE CDK5RAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="MTTase N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="93"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR07456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="458" mass="51543" checksum="821B8D221BED4D25" modified="2025-10-08" version="1" fragment="single">MLAKNLNKHRWVWEKKFNNFITVLVWSCYFQADVVMVMTCAIREGAEHKVWKKLHYLAKMKRRKMSRGVGPQMKIAILGCMAERLKTQILEREQLVDIVCGPDAYRDLPRCDNMCAYCIVPFTRGRERSRPIDSILEEVRMLSDQGVKEITLLGQNVNSYRDTSDSQHFGLPDLSIKPTLSDGFRTVYRARSGGRRFSDLLDKVSQVDPEMRIRFTAPHPKDFPDEVIELIKDRPTVCGQLHLPAQSGNDDVLSFMRRGYTGQAYRQLVDRVRSILPNVCLTSDFICGFCGESEAAFEDTLALVRDVQYSMVFAYPYSMRQKTHAYHKLIDDVPADIKQARVEQLQQEFRRGAGERNKSLLGHNHLVLVQGPSKKGTGTLFGRNDGGLGVIFPDTEITNSTAQTLHGEGVEISSIQSTGQCTVPNTGQCTIPNTGQCTIPNTGQCTIPNTGQCTIPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHA5</accession>
    <name>A0ABY7EHA5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="302" mass="33994" checksum="84C28E2141BF92AC" modified="2025-10-08" version="1" fragment="single">MHVELQNDFTINMKGCGVQSLLQFKTVDLLRSLNTKVGFDLRRKAPLSPGLIALITITSTFVFFMTIMLIVCIGEYCQYMKRKKSKRQVHERKPRHNQNRSTDGEICSGTSISQSENTSTAVHNNPHSSPTKIELKHASAYTNAFENTQKNSIKVESRKDQINNDKKNRRDKREVDGLGVKNDKQELTALVSRSVTSDRFCDSESSVRSSIDIDCDIKCATVNGTNRESVRLDSQSYDDLEADGEILCDSVDSKEGFYILKEHLLQSSSWKCRIAAATDSNAEKYTTSSMLAQIQVDTEQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHP0</accession>
    <name>A0ABY7EHP0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="778" mass="91176" checksum="7D40D04F2D505349" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EK53</accession>
    <name>A0ABY7EK53_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAN-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046644064" description="PAN-3 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17637" checksum="22DAA4319D62F750" modified="2025-10-08" version="1" fragment="single">MSFIFLEILVLSLIATKAESKDNFRAKVYTGKEVKTTNSTTLGVSLIQCQNMCVLARRMGTSNICGYDKVSKTCFYSFDTEYDVLSTSEVTKVVLIPVEDACQSSEYLVNGMEPVSDDQITASSVFNEAHDTNGSRLHSVTTSSRVGAWVAGTADTNQYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMS2</accession>
    <name>A0ABY7EMS2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YMD2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="439" mass="49229" checksum="2D27EB5C3D5DB7CB" modified="2025-10-08" version="1">MSVFNEEKFKEGLVSELALFDLPSTQTSVTNIYDEEIRPMSQTSSDGPFEFRISGQNSMDYLDLKNSRLFVKAKITKADGTAIGDKSANKVGPTNLFLQALFSTVEVTLQNKATITCNYNPYRAYIPTILKYGPDANNQLTTQLFQMDDADAPDVTDPNGTNDGLFVRNKLVADSKSVDMQGPIFHDLFDMDRYLLNEVDVKVKLYRSSIDFCLMVGDAVPYRLVIEDIYILTRKIRVNPAVIYGHSKILEKQNALYPYNKTEVKSVSIATGSTTFSWDNMYQGRRPNKLILGFVKSKAVSGDIKTNPFNFENCSIQQIAVYCDGLAVESNPLKLDFSSTGGTSTIRPYTDLLMSAGKWRQDEGSHLDRAHYISGSTLFVFELEPDFSHHGEYLSLAKTGNVRLDVVFKDPLTEPMSCIVYSQGPGYFEVNKERDIILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPL1</accession>
    <name>A0ABY7EPL1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026277</name>
        <name evidence="1" type="ORF">MAR_036261</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="69" mass="7787" checksum="109C0D0EF63448D0" modified="2025-10-08" version="1">MAQETWRTSTMVFRRSSVNDYHLLTTSIVTPNFHASGPRCLQCDYSAKRLTAFADELAEDVATKQAMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPW0</accession>
    <name>A0ABY7EPW0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="204" mass="23259" checksum="CCD354F02032F3DD" modified="2025-10-08" version="1">MNDQNLKAIINQKVDKAERPVCSEAVEAFQMSHTLYLKDKCIVEELKEHMNGHNYNVLEEFEALKAALCTLPEKIISQIKPPQEVSFKLLLKNCNPEEEKEMSEELVRLFDTEIKDNSIELSDDDCTKVKDAVRSLVKRFKNKGVKCLKDACECAMTNSVDKYAQKPVLSKDPSETYAATNIHILNWCNITPQRIWKPNKGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQP2</accession>
    <name>A0ABY7EQP2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HETE1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_026453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883:SF12">
        <property type="entry name" value="SEA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883">
        <property type="entry name" value="YIPPEE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045189958" evidence="2">
        <location>
            <begin position="22"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR12273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="513" mass="53696" checksum="E8C8426FAA23BDA6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERA4</accession>
    <name>A0ABY7ERA4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PP2D1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_025649</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="163"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="652"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR11469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="726" mass="80504" checksum="F769212B2A894C57" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESX3</accession>
    <name>A0ABY7ESX3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SPG7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_025843</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF8">
        <property type="entry name" value="PARAPLEGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="295"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="646"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="647"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR11663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="673" mass="75479" checksum="3C53D524B3A5B29F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETP6</accession>
    <name>A0ABY7ETP6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RELCH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_027518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040362">
        <property type="entry name" value="RELCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32059">
        <property type="entry name" value="RAB11-BINDING PROTEIN RELCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32059:SF0">
        <property type="entry name" value="RAB11-BINDING PROTEIN RELCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="HEAT" evidence="1">
        <location>
            <begin position="689"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="508"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="528"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR13338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1090" mass="121931" checksum="D268777466D16794" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUH4</accession>
    <name>A0ABY7EUH4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNAT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF32">
        <property type="entry name" value="ARYLALKYLAMINE N-ACETYLTRANSFERASE-LIKE 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="109"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="234" mass="26834" checksum="E625E98CF8CD43AB" modified="2025-10-08" version="1">MIPHQFTQLHCSAFAKTKKEVCFPEGELVFITEDRLDDALSMPRQCFIDDEPMGKSIGVQFTEEFKLYWLTTFRQGLSFMLVNPTNGDIMGFRGICTALKEDKEEVNQIKDASLRKIFSILGLLVKEADFFGRYDIEECFHFFGLGVAKQYRKRGIAKRLMEAGIVFLRNLDVDPVYIKSEGTSNFSQKTFEQLGFETLAEIKYEEYEVDGEVVFKNTGEHKSVKAYGMKTSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVF4</accession>
    <name>A0ABY7EVF4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GBP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_004038</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GB1/RHD3-type G" evidence="5">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR13933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="129" mass="14240" checksum="ACDCD036BAFDD825" modified="2025-10-08" version="1" fragment="single">MASNENPTDSSAIKELGTKLKLFEQTSKGEPTQTRNADTPHMKRSGPFQNQVTTERESPSPRTYLSTHDSSVFKKPQCLISAIEANTLKVCDDVLDQISRIDKPCVIVSIAGLYRTGKSYLMNRLAGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWZ0</accession>
    <name>A0ABY7EWZ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="89" mass="9729" checksum="CD14AB9EBA8224C9" modified="2025-10-08" version="1">MSPSGLKWSEPVEDTPLELGILRIESELITLDLSTPCLSDPMSPFGKFQLRRDQTGRKLGKWLSTNSPSAWLIRGATALNITAQSGVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F129</accession>
    <name>A0ABY7F129_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="102" mass="11629" checksum="4EB8B51309135222" modified="2025-10-08" version="1" fragment="single">MSVSGVLMNMFTQYGCCDTLVSEKGSRFTATKNRGLQFTPNFVQHCHSICYKANTIHEKSLQQLTYWSIQLCSKYSVFTDLNSVLLVFLHTSFTILECFAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1Q9</accession>
    <name>A0ABY7F1Q9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SYFB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B3/B4 tRNA-binding" evidence="1">
        <location>
            <begin position="107"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="554" mass="61654" checksum="8216B2DA647812AC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F226</accession>
    <name>A0ABY7F226_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="256" mass="29330" checksum="4DE7640D4381F5F9" modified="2025-10-08" version="1">MGQLVTEIIIAIYRRLEAMGSSSTKYEREKTGFQPDLERSPSYFRSIEHGHSTWAGNNWSSLSRLDNALSTVRVCPKNAESLRRILQDRYFSDWGEACDVKEYNGFTLTELPTLVDKIGDVFGDKKQEIQRKLGQIQFCEYLDVKVFEFTFGEDLSSGEIQFGMIAISKSGIQLEAVSCLYQLNFTLAPVKVTKETKSYFLGFEIGSSTTTWQEGTRLELVTQKELLNFCRYKALKEFQNRHLATRINCVPSIEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F227</accession>
    <name>A0ABY7F227_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047509411" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="56" mass="6122" checksum="9839D900645E5221" modified="2025-10-08" version="1">MKITGSHSAVFSVLVKILLPSAIALRLNSSQVYCALDNVRIIFLESLTSETTDARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3W2</accession>
    <name>A0ABY7F3W2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vesicular, overexpressed in cancer, prosurvival protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_030901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046211620" description="Vesicular, overexpressed in cancer, prosurvival protein 1" evidence="3">
        <location>
            <begin position="25"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR16307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="21422" checksum="AF0106C44C536848" modified="2025-10-08" version="1">MSCQRVVWSLVVVLLTLITDVCRAGQFCYFLHEDYYTLRQIYCESGCCRDYGDDDEICCFTWSVGVILGIGFACVGFIAVVIFLVICCQQMKKRGRLGSVVHPAGTGGAHGTPYPQNNTFVYASAPPAYQYAAYPPQNIYSTPGSVAPPPYTAGTQPAYAPPSMNNPNDMSSGNAHGGPTAPTNPAYPPRSYGGYGTGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3Y4</accession>
    <name>A0ABY7F3Y4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="279" mass="33476" checksum="DE82ABA817C78404" modified="2025-10-08" version="1">MNIWLVDLNPTARFCPRRRRNEVGIYISVYDAKATDTNEVGLEHYFLMHTTELLYEEFCKVGTVNIRARFEAKKILNDMYIERFETAYDIKLVRRLKKYQDVLARELSKMRDLDNEMELNRDQFMNCVRNTLSNTQNSIKTLQQYKDIAASPKARKMFHKDLLDLYFTIIEKWRMYYKIFEVEIVTPLLQIHTICENEKQTEIRRKIIAMVREMQQMLEPNYDLQTVSHPEMAKKIIRREVPVFLGLLSLVPMGVDRVADIDIMIDEYSREFRMDFIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F6N8</accession>
    <name>A0ABY7F6N8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF1">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1328" mass="149067" checksum="C9960218314B476F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7C7</accession>
    <name>A0ABY7F7C7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KT5AA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051760">
        <property type="entry name" value="KMT5A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46167">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46167:SF1">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="85" mass="9979" checksum="DEE3E2F65A79D9E6" modified="2025-10-08" version="1">MDATSELDVGPRLGRLVNHGGKGKNCVMKTLEFNKRPYLCLFAAKDIPQGEELLYDYGIEDLPWENWWPLLTIWRTCWRPRLQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7H4</accession>
    <name>A0ABY7F7H4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045347223" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14764" checksum="7E4AF883BD9E75C5" modified="2025-10-08" version="1" fragment="single">MCVGSFTYVSACLFVRACVHAGDCRVIRGYMEHLHVYQGYRGSVRTWGYSHMYQWGWSSHKCIRAVELVGMPGRGTCISGDLVFGGDARERVYGSRRYSHMYQLGIESAHMYLGDGVLLVCPVGAHESGECGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F995</accession>
    <name>A0ABY7F995_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_000528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR18690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="294" mass="33225" checksum="1916F651306DF531" modified="2025-10-08" version="1" fragment="single">MATWLVQEHSRIVATWLALEQSRIVATWLSIAGLWLHGLYKSIAGFWLHGLYKSIAGLWLHCLYKSIAGLWLHGLYKSIAGLWLHGLYKGIAGLWLHGLLEHSRIVATWLSITGLWLHSLYKSIAGLWLHCLYKSKTGLWLHGLYKSIEGLWLHGLYKSIAGLWLHGLYKSIAGIWLHGLYKSIAGLWLHGLYKSIAGLWLHGLYKSIAGIWLHGLYKSIAGLWLHGLKEHSRIVATWRSIAGLWLHGLYKSIAGLWLHGLYNSIAGLWLHGLYKSIAGLWLHGLLEHSRSVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9A1</accession>
    <name>A0ABY7F9A1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="255" mass="29934" checksum="5F046D3733F95906" modified="2025-10-08" version="1">MFIRINFRKKANGPKMRVAKELRRTKQELKDLKEAHENLRRKYRSTMRSIQRMNKKSDKHSNTPSSKAKRLTENMDLSRQQRLTVRKELVFANAVCDEIKDAAHRAPIKAKKILQNLVAGNVLKKYKLLQMFGKKTVSSNQVNTTILTHESVPDSVSIDTQEKYHAGDYVAASYLNRWYIGEIMNCDDEDNTYEITFLEKRKKMFQWPTRPDEIWVNYDDILCKVSTPVASGKSKRMLVLPDNDFERVERLFDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAE0</accession>
    <name>A0ABY7FAE0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="1">
        <location>
            <begin position="79"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="155" mass="17650" checksum="73F4D2F851FF7B2F" modified="2025-10-08" version="1" fragment="single">TEVWQGITKCKKELKQTTLEQFFKVNKGQKANSFATECSYSGTSLQSHDPADTVIDQQHGWSSKPSLETKENTHTFPIGTVVWGMFGRGKWWSALVIDGAMVGKTTKPGFYWVYWLSDDKISQLKPSCVEPIHKEFQTRCRQNSGIKLMRCGIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAY0</accession>
    <name>A0ABY7FAY0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MOT14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_001108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR19270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="478" mass="52077" checksum="941F1CC61ED8EF78" modified="2025-10-08" version="1">MLLKVTGFGTTQSIGVYNIEWLRYFDAGAAAVSLVGAINLGVFLGAGPLASVLMSRWSHRQVALLGAILSNLGLICMPFAPNLPFMYVFYGVISGLGNCLSYVPSHVLTGLYFSKHRSLATGIATAGSGLGSTIFPIIMYHLIQHYGWRGSLFIVTGLNLHQILFAALLHPVPKDIQASVSCADELMEMKEKREMSKNLETSQDIQEKLLNGKTCNDVKIVDGDFSNENGEIEVNEMENLSKATSAMLECRKNSDTKLTTRVKLVNHLKTVFTVDFVIFFISNICWNAGGAIVLIFYAEYAYTAGLDKEDSSTVFTMCGAGACLGCILGGFLGNVKYFNRIWIYIVGNIGVGLISMLIPWRVMHTFWGLFMLIFIFGLMFGIILGLLVVVTSDLLGTKALGDGFGYLMLANGLGVFGGPPLAGILIDLYGSQDPAMYLSGAFSTMGGLIMCLVPLRRWLFPITEKQYLPSITLEVVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBY4</accession>
    <name>A0ABY7FBY4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTBD3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_001523</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd18488">
        <property type="entry name" value="BACK_BTBD3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18282">
        <property type="entry name" value="BTB_POZ_BTBD3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049737">
        <property type="entry name" value="Btbd6a-like_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF4">
        <property type="entry name" value="AXUNDEAD, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="110"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR19685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="512" mass="57247" checksum="A7780FE0C11D54BA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDH3</accession>
    <name>A0ABY7FDH3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GRDN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_001262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HOOK N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="847"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1211"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1431"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1636"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1673"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="158"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="359"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="721"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="812"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="901"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1050"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1159"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="847"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1282"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1319"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1348"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1392"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1463"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1475"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1502"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1537"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1636"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1673"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1715"/>
            <end position="1737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR19424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1860" mass="212145" checksum="94562572FE169A78" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEF9</accession>
    <name>A0ABY7FEF9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TEuncharacterized</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_001392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046015534" evidence="2">
        <location>
            <begin position="22"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="36"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="299"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR19554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="513" mass="57833" checksum="76142279A103D20D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFA8</accession>
    <name>A0ABY7FFA8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PREL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_014844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="103" mass="12040" checksum="544C8AFC5CB4086C" modified="2025-10-08" version="1">MKFFTLDTVFQFSWGQVVTAFWQRYPNPNSKHVLSEDVIERWLCGDKLFTKRLIQKKGSIPKWGERIITGCSHAYVVEESMLDLASHTLTTYTRNINLKEISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFP5</accession>
    <name>A0ABY7FFP5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MORN4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_014979</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052315">
        <property type="entry name" value="MORN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46614">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46614:SF1">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR21005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="144" mass="16010" checksum="951EF75216EA0466" modified="2025-10-08" version="1">MKGSYQYPDGSQYKGDWSDAGQREGYGQMKFTDGSQYFGNLVGGLCEGHGVMVFSDNSRYEGEFLQGRFHGYGVFMRCDGMKFEGQFQNGKIFGNGMVTFTDGSHGLPRNEGYFEGNKILRRGKCPDIIHTANKAADIAKNLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFT2</accession>
    <name>A0ABY7FFT2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BRD8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_015032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="96"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR21058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="163" mass="18405" checksum="8B2362BABCC3D604" modified="2025-10-08" version="1" fragment="single">DDLSSRPSDAETSDDDGDSSVTNMPPAGSAAFSESIPNSPHSSHCSDTEDDKAYKAWKKSIMLVWRGIANHKYGYLRLMVRQNPAPVINVKDDFAPGYSLVVKRPKDLTQIKRHIESGTIRTTSEFQRDMMLMFTNAIMYNNANHDVNRMATEMYNDVLEQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFV3</accession>
    <name>A0ABY7FFV3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CC170-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_001725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039139">
        <property type="entry name" value="CCDC170-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18863:SF6">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18863">
        <property type="entry name" value="TSEC-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="333"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="425"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="563"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="825" mass="94973" checksum="743B7B202A584D7C" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FG14</accession>
    <name>A0ABY7FG14_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_000014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR18176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="117" mass="12897" checksum="2BC773623254BADF" modified="2025-10-08" version="1">MESVNIPAGTPSSDCKLKPSRPIPLLVWFCAKPPKPSLRAGSPSHMKSSRESSEPILWLCEFTPVSMAVQHLTMTRLVQLLDMVITLLAVPIPSLVRLLLKVLVARLRLLVGHSHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGE8</accession>
    <name>A0ABY7FGE8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="165" mass="19650" checksum="B6A80215EF5C6480" modified="2025-10-08" version="1">MYCIHLPVRYKRYIAPNTVRRELYSLHCPKHSSLGTIFQTQFNLKLKRSTQLNITMSTEVLVDGMTIAEMQATLEQAERKFRRACDQIVLLNERLSSCQIRYKKARDNNRKSLRYPLRLRLAMIEGIRNMYYDYATQKVEEIERLRNVDYIIDDIYMSDEEAAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGK0</accession>
    <name>A0ABY7FGK0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PSTA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34999">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34999:SF5">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="739" mass="84405" checksum="9E496FC802D37C4D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGL7</accession>
    <name>A0ABY7FGL7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029774">
        <property type="entry name" value="CSAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31022">
        <property type="entry name" value="CENTRIOLE, CILIA AND SPINDLE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31022:SF4">
        <property type="entry name" value="CENTRIOLE, CILIA AND SPINDLE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15748">
        <property type="entry name" value="CCSAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="347" mass="39819" checksum="15EF52EEAF1C7849" modified="2025-10-08" version="1" fragment="single">CIERATLTPVNMVYKKSEYGRNYKISSLIQNIPVYEEHLNYRHIRRERECAHTPFSWDGEVESSDSDDKLTPAEEQPEVPEIRLADLAITEDEEEELPQESENESEDDIAKEKREAKEKDVRASKANLGACDVDIIRQNNDLRKSAKEKLNKYISKVNTDEKMGKTFAKPKVTDEKCFVKRSKPRRPDRVGKLSGARPLSAPGARPKSAPPPATANERPVSQAGPSHPFYNYGGGAGNRVLGDKKTFNVRASAAVYPAALRAKKRNLLLVEQQQEKQRSASAREKRRKARFNERMSRQTAIWESEYRRSYPAYEDNEYATTERDPRKRKSQLKHCKIVLHSWILDYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJ57</accession>
    <name>A0ABY7FJ57_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SAMC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_016199</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR22225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="211" mass="22624" checksum="3FDE8F1DC84856C4" modified="2025-10-08" version="1">MTHESGYFVSALLAGGAAGTSVDLALFPLDTVKTRLQSAKGFWKAGGFSGIYSGVGAVALGSAPIAALFFVTYEGVKYLAKPRVSPQWEPVVHMIAASAGEVGACLLRVPVEVVKQRAQANRQSSSLNEFKHTLKTEGILEHCDQGNTLLLHSVSTLGGIKGMVVKISRLYSGLLPRMLWISIGGAIFLGVFDKARKTVYTLYNKYDEKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJM4</accession>
    <name>A0ABY7FJM4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAR14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057044">
        <property type="entry name" value="PARP14_KH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23084">
        <property type="entry name" value="KH_PARP14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="313"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="558" mass="63728" checksum="306CCDE329A6A19A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FK39</accession>
    <name>A0ABY7FK39_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_016532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047312823" evidence="2">
        <location>
            <begin position="27"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR22558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="788" mass="86946" checksum="5574BD1158BB0A55" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKB0</accession>
    <name>A0ABY7FKB0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IF2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="612" mass="74030" checksum="844FBC089B594A15" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLM3</accession>
    <name>A0ABY7FLM3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR23090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="506" mass="58472" checksum="A7D3BFA72FD5CE2A" modified="2025-10-08" version="1" fragment="single">MTFIITDKVTLSKAIYTTDMLITQYPMTLTNSSIPNDKNLRICTWNVRGIMSSAASLSNLLVSQNIDIAFITEHKLFNHSKYFVDTIQHGYRNITVCDENVNLYNNIRCGKGGVCIMYKSNLDYSIKHINESINDRICGPKFTYVTMESMLDHIIISNCDKELFQHVEILDDDMFSVSDHLPVFAIISVPFMRTTDVNIKRHIAWHKLNQTHISAYEERLTGRLQIEETEDVNVIYNTIIKAITSASQQCLPHTKYNRHAKPYWAQEVKSAYNKQREARQCWIAKGQPRGWHHESYATYKRYKRSFVTIQKAAIEKVERTFNNQLIEAAECDNKLFWSLVKSRKHKKSTVCSQLSYENETARDPESILEIFTKYFKDVYTPLNCDHFDNNFKETVEKEVHRLKDINGSDVVRIRQGGILSTWIYNLFINGLLELLERSNQGTNIINIATSNTTLADDIALSAISPSGLQNLLNTAYEYTCKFRYMINSAKSFIMIFGDHSRNKTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMM2</accession>
    <name>A0ABY7FMM2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LDP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_002309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR20471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="199" mass="21993" checksum="0741498EF3BE7CCC" modified="2025-10-08" version="1" fragment="single">MSDERYDFVVLGATGFTGQFVVDEVARVADQEKLKFAVAGRSMEKLQKVLTESSQRTGKELEETPIIIADVKNYRFYGEDVVKACIENGAHHVDISGEPQYLEKMQLLYSGKAREAGVYIIGACGFDSVPADMGVAFATEQFKEIHTHYTSISSIQGLAGNVTTLESALHGFAHAAELKPLRKSLYPNRLPRSKYPLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNP9</accession>
    <name>A0ABY7FNP9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">XPP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_014820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="4">
        <location>
            <begin position="223"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR20846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="452" mass="50643" checksum="C1F57A2786F153F4" modified="2025-10-08" version="1" fragment="single">MWTDGRYFLQAEKQMDGNWALMKDEVWTPLARTLKSNGHSLVPVAENLIDLVWSDQPDPPSNSLMVLENYYTGCSWQDKVVDVREKMKEKNAGALVISALDEIAYLFNMRGSDIEYNPVFFAYAVVTMDSVHLFTNPERIDKKVRSHLHLDMPPENEGVKVTIAPYNNVKNFVADLVDNVSGKIWISDKSSYGLVSSIPKLRRLIAASPLALMKAVKNAQEIEGMRRAHVKDAVTLCEYFSWLERNVPLGTVTEVSAASQLENIKQFVIVVIWTGGLCQSEFCHNIQHSPSPETDKTLSTEEIYLCDSGAQYRDGTTDECFTRVLKGHINLCRSVFPNGLKGTLLDSFARAALWEAGLDYLHGTGHGVGSFLNVHEGPCGIHQRINPHEVPLQEGMILSDEPGYYEDGKFGCRIENLVLVVKKETKGSQGFVFQFRALSGENIILDQYCLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQB6</accession>
    <name>A0ABY7FQB6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BSDC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_036582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="143"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR22913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="557" mass="61815" checksum="3C8C3F51578DE206" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSU9</accession>
    <name>A0ABY7FSU9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar fusion protein MON1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_011004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an important role in membrane trafficking through the secretory apparatus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MON1/SAND family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="4">
        <location>
            <begin position="139"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="5">
        <location>
            <begin position="301"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="6">
        <location>
            <begin position="429"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR25300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="540" mass="60895" checksum="BAE72CFA4D87317D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FT02</accession>
    <name>A0ABY7FT02_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial inner membrane protease subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_011010</name>
        <name evidence="13" type="ORF">MAR_011052</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of 2 subunits, IMMPL1 and IMMPL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR25306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR25348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="182" mass="20740" checksum="7FBE9F6A9D3B4C0F" modified="2025-10-08" version="1">MDILIYFSCYVFGRNTNRNFVLCCDIIAFDGWQVSTNIALDTNDALSSRKYSKEHPSRCENKFECLVMAPYNPKNTVIKRIIALEGDSVSHVNSDDVWVRVPRGQCWVEGDNPRFSKDSNSYGPVPLGLIQAKATHIVWPPRRWCKLNSSNNEYSLPPDRVMPNHITSSHNDYNGRPCTTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWA1</accession>
    <name>A0ABY7FWA1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mesencephalic astrocyte-derived neurotrophic factor homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">MANF/CDNF-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_010715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045333">
        <property type="entry name" value="ARMET-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019345">
        <property type="entry name" value="ARMET_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12990">
        <property type="entry name" value="ARMET-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12990:SF5">
        <property type="entry name" value="MESENCEPHALIC ASTROCYTE-DERIVED NEUROTROPHIC FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10208">
        <property type="entry name" value="ARMET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045111412" description="Mesencephalic astrocyte-derived neurotrophic factor homolog" evidence="3">
        <location>
            <begin position="24"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="ARMET C-terminal" evidence="4">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00032923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR25011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="126" mass="14464" checksum="651017DC9427A170" modified="2025-10-08" version="1">MSQNSSLLCACVTLMVLCVATSGKKPLKEEDCEVCVNVLRKFEQKYPDVKEKAPGEIETLFKKFCKTVKDRDERFVKDLKKILSDWDEERACRGCSEKSDFVRAVKELMPKHAPEAYAKLKARDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWW5</accession>
    <name>A0ABY7FWW5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLXB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_011836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013548">
        <property type="entry name" value="Plexin_cytoplasmic_RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF44">
        <property type="entry name" value="PLEXIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08337">
        <property type="entry name" value="Plexin_cytopl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Plexin cytoplasmic RasGAP" evidence="3">
        <location>
            <begin position="248"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR26132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="350" mass="39166" checksum="AF25240B81C63A11" modified="2025-10-08" version="1">MIYPEKGFLSGGTVLTVKGKYLNNANAGTVRLVEQCVIDTNSSAQVLCRVPPASKGIIQELNAKASSSNKRKKRSAQCVECVTVTIIVKLDGVEHSFNISYFHDPSISKFDQGVLLYQSDQQYLEIKGENLNLVAAKHDINITIGIDVCNVVELEGDFMRCKAPSSQPQPGIPGATLPEVNVCTLAELIVIMVAFFVCKYRKVGSKAKALEKQLNDLELEIKHVAKEEFLDMQTSMSTVNRNLIEQGFPYHSYQQYACNAMFATDYLMSDPVMSDELRARARTGMERFQGLLENKFFLVSLITTMEKQKHFFIKEKSNFAGNLCAIMMGHSRRPVNLPRDQMSAVEQEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FX39</accession>
    <name>A0ABY7FX39_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAIP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_037395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051367">
        <property type="entry name" value="mRNA_TranslReg/HistoneTransl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254">
        <property type="entry name" value="EIF4G DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254:SF15">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="666"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR23726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="778" mass="87792" checksum="06F90CA51FE7526F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZ25</accession>
    <name>A0ABY7FZ25_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TCuncharacterized</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_013114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1479"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1513"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1546"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1587"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1629"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1673"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1700"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="22"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="1476"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="709"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="938"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1742"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1742"/>
            <end position="1752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR27410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1763" mass="201708" checksum="EEEC062484B8B972" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0L3</accession>
    <name>A0ABY7G0L3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_013654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="454"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR27950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="538" mass="59565" checksum="5D745AE34AEDE1F1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0P0</accession>
    <name>A0ABY7G0P0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUSTY-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_012498</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051302">
        <property type="entry name" value="Dual_SerThr-Tyr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46392">
        <property type="entry name" value="DUAL SERINE/THREONINE AND TYROSINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46392:SF1">
        <property type="entry name" value="DUAL SERINE_THREONINE AND TYROSINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="141"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="301"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR26794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="335" mass="38423" checksum="A843245CB836154A" modified="2025-10-08" version="1">MCLKYNKKKNNMLAECVSVLVMCLMYEHKIIFTFHQIVQGMPWSQSPRIDDDWKKKVAAEMLASLSATRLAKSISSQIKDRLNKSHDAFLTALKQLEMKHSGRLTKIEEERLKLRKVHAPRVAKVALESTSLKDVILYGMPQMGREIGRGQYGVVYSCDSWASYTPCAIKSVVPPDEKHWNDLALEFFYTKNIPDHDRVVMLRGSVIDYSYGSGTPAVLLIMDRLQRDLYSAIKQNLDWVSRLQVSIDVVEGIRFLHGLRPEHLPVFDDECWDLMSNSWECEPAKRPLLGEVHATLQGIYDRYRNKPGGPTKTAKESPPKPLTQKNVKYKLKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2B9</accession>
    <name>A0ABY7G2B9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAT4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_013378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF31">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="68"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR27674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="148" mass="15575" checksum="DC462AD6C278214A" modified="2025-10-08" version="1">MAWQPLLVNVWSEERGGGVKSLILFAHKDVDECQTITCANGGRCVNTDGSFECKDCLEGWTGQLCNTNIDECTLPGNPVCKNGGLCTDTEGGVSCNCTGTGYEGTRCDVDVDECDGDPCLHGGLCSNSVGSYACTCTDAFYGKNCEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3Y6</accession>
    <name>A0ABY7G3Y6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="309" mass="36798" checksum="0F9CA7F7E6DD8F3E" modified="2025-10-08" version="1">MNVEDSWSFLLRHMDFCVENFIPECNTKGRCKKPKWMDYYCVRKVKKKYHAWKRYTYSRSYRDYQSYCKIRNSTTKASRFSKKKYQKGVAESSKTSQKSFWSFVKGETNTRSGIGDLRDKNGNIATLIKDKANILNDFFASVFMREDNSEIPNFEDNKDWLLKFNIKKCKIVSFGNENFYNDYNMIDENGNVHKLARDFSEKDLGVLFTNNLNFETHINNTVNKVNKIIGLIRRKFTFMDKSLFLILYKSLVRSHLDYGNLIYFPYTKKCKQVLKNAQRRATRLIPEFRGLSYQERLNELNLPTLDYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6Z1</accession>
    <name>A0ABY7G6Z1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="131"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="268" mass="29491" checksum="96EF37CB21D5F7C9" modified="2025-10-08" version="1">MDLHIMYAPIPDSTTPIKSEFGAPVSSNVTLTFYADAVPVPNASGYSWSRCINTTEGKQIANSSDAERSMVYRTLVENDKFIIQSKGLVSKLTLLNITIIDYGEYKLTVQNGIGRSWEQSYTIWREGRPSMPSEFAIVAGSATLSSVVVSWKGGSNGGSRQTFNVEYAIVEPNKEVFHVSVEDTEQDNENATLTQLSSNNEYTVKMTSSNIHGTSGYTDEINFRTMQDTTRSEQDVYSHYEIADRANMDRMISAETHGTAGTGNGNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G778</accession>
    <name>A0ABY7G778_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NETR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_032795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045818980" evidence="2">
        <location>
            <begin position="23"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="3">
        <location>
            <begin position="26"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR30253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="318" mass="34072" checksum="A2AB115A11ABF1F0" modified="2025-10-08" version="1">MELKLFHIGLLQVILQLHFGTASNTIRLVGGSNQYNGRVEILHDGAWGTVCDDEFTDTNALVVCKMLNYPTAGAKAITNLIDLPIAPSQIWLDQFRCTGCEQSIVDCLHLLPWGSHDCLHNEDVGVVCSSSTGGAGARVITNLIGYPTAPVQIWLADVSCSGCEKSFDDCYHSNLLDSHNCSHNEDVGVVCPSLSADEPTSIASTVRTVSIITPTNNESSNIVLLVIPTAVSCSLVCQQNLRNKSQSGECSQVQNSTNINECNVGVEENATIGVNNEIGMPMEIPLDQLEDTNGNEMDSNDSDIRIVTNCALDGAEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8B8</accession>
    <name>A0ABY7G8B8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="140" mass="16590" checksum="585F6FF237626C85" modified="2025-10-08" version="1" fragment="single">DFIGRVSDRPDLVEDDYIVSIIDGERRIEIVDCPGLQDGEDASEAVAVAEKLIQEKTEHDRHIEQAKKEKIRDDERKKCEQEFKIQRRYDTFKQRQADKAIKDKEKNKCKQEFQNQRRYDRLADSVYDNKLAYIVNPLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAT1</accession>
    <name>A0ABY7GAT1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="134" mass="15646" checksum="305DA54987C23FF7" modified="2025-10-08" version="1" fragment="single">MKLLRHFSKHRISLKHMLQQKNSIWYTRAVNIDSSWYTPAVNIYSICYTPAVNIDSIWYTPAVNIDSIWYTPAVNIDSIWYTPAVNIDSIWYTRAVNIDSIWNTPAVNIDSIWYTPAVNIDSIWYTRAVNIDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GB80</accession>
    <name>A0ABY7GB80_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLXB2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_034214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF70">
        <property type="entry name" value="PLEXIN A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045976072" evidence="3">
        <location>
            <begin position="29"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="821"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="979"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR31672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1039" mass="114878" checksum="9A9ED39991967953" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBV8</accession>
    <name>A0ABY7GBV8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_033954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="144" mass="16563" checksum="40319DF6441E263D" modified="2025-10-08" version="1" fragment="single">TQLFENTENERSYELLESELRKLGFCFSRKIFKGNGWDSITSNSSAVYNLRSKDRYFLQPLEIDEEICRLKALYARSGVPDNEKPTFPECNKTWSIDKVKSALKGFSHLQGLGQGFGKLNVYIDNVSSEQKEETIKLVGRKLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GCM8</accession>
    <name>A0ABY7GCM8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_033649</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF157">
        <property type="entry name" value="DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="30"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="221"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR31107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="447" mass="50588" checksum="6370FD422189B452" modified="2025-10-08" version="1">MAMADTVRMLYNSVKEKFKFELKDEQVNIISALLGNRDVTALLPTGYGKSIHSKESFELPHVSVVVSPLISLMKDQQQQLHSWGIKSAISSDEQINVKDIASADVSVIFVTPEALIRNQWRDLLLDSKFQKRLCLLACDEAHCVSEWGENFRPEFRQISTVRSLCDVPLLAITATATDKVRADIIRYLDVKDDAYAIGIIPDRPNITLCVKERCSHDEQQELAWLLEKVKAEDDPRTMCKTVIFCRSYLMVFRVWSWLHKSLGFQTYAGEEQENHSLVEMFTSSSPEKTKDRILAVFSSPDSSIRILVSTVAFGMGVDIRDIKLVLHWGAPRSFLSYWQEVGRAGRDGNEAFAVMYPYRRSMMSSVCDKDFAASIAVDQCLREKTLIALTTCDMKKEDIPQRINCKDNNCIICECDLCRCCSVCFSRCSCSGKLDVIAKMCILKSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D847</accession>
    <name>A0ABY7D847_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WHITE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_006310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046251003" evidence="8">
        <location>
            <begin position="24"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="71"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAQ93839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="479" mass="53576" checksum="93330CF5214C1A3E" modified="2025-10-08" version="1">MAPLGLTMLCLLWTIRLLPTIEAITVVIWTSKTPQKDVVPLPLPPGTSTHGNAAFDSHHHEKNGSFNHTCHHTNDAYHSMVDSMETVTLSWKNVNVHVNPVNRACCRGPDPSVTPKHSLTASGDIRGNGVDVGSGIRNISAYVQQDDLFIATMTVKEHLTFRALLRMVNEVSRSRRLERVQEVIKELGLTKCQDNMIGDPGRLKGISGGEMRRLSFASEFLTNPPLLFCDEPTSGLDSFMAEKIVQTLKVMADKGKTIVCTIHQPSSEVCALFDHLLIMAEGRFDEAFSNTSRYEASFLTQFRAVFARSWKTMIREPMVVRVRVAQTLMLGLILGVIYLQLDINQEGVMNINGVLFLLLTNMTFSNVFGVLKSFPLEMPIFLREYGIGLYRYIVSAAANSVTTALAISPPLMIPLMMFGGFFLNSDSIPVYFIWLEYLSWFKYANEVLAVNQWQNIDIIVAYRIIAFIILFAKARSSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBB5</accession>
    <name>A0ABY7DBB5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CIR1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_006538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040014">
        <property type="entry name" value="CIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13151">
        <property type="entry name" value="CBF1 INTERACTING COREPRESSOR CIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13151:SF2">
        <property type="entry name" value="COREPRESSOR INTERACTING WITH RBPJ 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ94067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="464" mass="53325" checksum="95F1701F661C2B40" modified="2025-10-08" version="1">MGKGFNNYMTKKFFHPSSKDNIKRVWMAQQKAEFDQKKEDEMVAQYRKEQDRDEGEQEVKFEWQRKYNAPREQYAKNDETILDQPFGIEVRNVRCIKCRKWGHVNTDRICPLFGKDLTAEPEQPKTSAYSLLESMRDDGFTLKQSLLGKLSDPKAANEQMLNDEDKDDPEVQFLKSLSSKQKKKLLKKLSKLQQNQAPEGKVEKKKKKKKKNKKKSGKKSKKRDSSDESDSSDEESPPKKLKRKRPQSDSDNSDDIERAPRKNGGIGSKSSIRKQDLKNGERDRERRGDTSRNDDRRDGRIDRSDQIDGNGQRYDGRRDSRRDRHGSDERDRGNEIRKDDRRRGRSRSRDGDNGNIQIYNESGGKVDKSGSRDRQCKDTSDDREVGLETERGTDKGEEMIEGDLGVEIEVEEGKLKKKGKVEVQGGEMIEGGLRVEIEMEEGKLKKKGKVEVQGGEMIEGGLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCY6</accession>
    <name>A0ABY7DCY6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TM220-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029377">
        <property type="entry name" value="TMEM220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34262">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34262:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15071">
        <property type="entry name" value="TMEM220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="185" mass="20604" checksum="5B68765C5DB4B809" modified="2025-10-08" version="1">MPEADRGGLKQTFQIMYVWQAVNLVMAMFFSLAALANLNDDDWYLWMPLYVVPALFAVSVVARPQLADNTLWNSGLVVHLTLCCAYALYQVVLLLEALSGNFQQNPLGHEAGREMGGLIIIIAWLVMCRFTSIARPSGSISNRSLMSALLLMSVTLAVLPLFLWSLCFVSDWHTRIAHCSGMFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFG9</accession>
    <name>A0ABY7DFG9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MSH4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_028338</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="8">
        <location>
            <begin position="169"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="9">
        <location>
            <begin position="501"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="654"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAQ95648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="725" mass="81404" checksum="13677AB645AFA92C" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DH76</accession>
    <name>A0ABY7DH76_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="279" mass="31972" checksum="6A2A385C64309C8A" modified="2025-10-08" version="1">MASLADQLKAVQLKKSTEPIKDFSSARTAGFMKDEDIKAYEKSVLENTDWKDTISDDERILLDVLENRLQNAMDVFTKDGFAFVKTSSRSAKDAPLVQNNFKQLYLSELDSYPESNRSENIKITCLLKAAFDALRVKTAGEVIDMFLRSERIYQDLLLAAVNQVSKYHEHFVIRKFVDIDVDMEFRGFVWKNELVALSQYNYAIYSERLASNKAMYGDMKLWVIEVNPYMETTDGALFSWQHEVPILQGAEGFVFRVTEKARPGARTILPQSVRALMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHE0</accession>
    <name>A0ABY7DHE0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NPHN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_028726</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="208"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="302"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="560"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ96036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="596" mass="66579" checksum="F4D279B9D4E59C2F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHR5</accession>
    <name>A0ABY7DHR5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_028846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ96156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="76" mass="8521" checksum="9062D5FA851459B2" modified="2025-10-08" version="1">MQSLEDHIDFHGYGSTAGWTIVETEMEAIVSDDGDDDIHIICSLTLRRNPVYFILNVLQKIENQEFSSSITSGTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHX1</accession>
    <name>A0ABY7DHX1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_028990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ96300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="75" mass="7830" checksum="72A68DDD5C3AAE83" modified="2025-10-08" version="1" fragment="single">MLVLPTSFPDKCHPNPCIHGSCFSDALGYVCVCDSSFTGKNCDSGTAKLTAAIKTQQTTLHMPTTPVSATVAPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJV8</accession>
    <name>A0ABY7DJV8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_029853</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="8">
        <location>
            <begin position="60"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ97163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="260" mass="29087" checksum="C7EA9006AC33C365" modified="2025-10-08" version="1">MAAPVCHVSAVKHITRRFLSCSVALQKTGLKKSKGNQSSNNWLQRQLNDPYVKSAQTEHFRCRSAFKLLEINDRFKIIRPGDTVIDCGAAPGSWSQVAARAINKKDGNKKDGMKGSQTRQNDRDGMVIGVDLQEVEPIEGVLMFSGHDFTLPDTQHKILNTLDNMYANVVLSDMAPSASGNKAFDHERISKLCLSVLKFSSQVLANDGHVVCKLWDGSERKDLLKVMERMFRTVKVIKPDASRSDSAEIFLLGMEFYLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DK92</accession>
    <name>A0ABY7DK92_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GGT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="471" mass="52608" checksum="43A7CCA22323556A" modified="2025-10-08" version="1">MSKHCSSTHSKHEQALLIYTLKLEREHEQALLINTHKLVKEHEQALLIYTDKLDKEHEQALLIYTLKLEKEHEQALLIYTLKLEKEHEQALLIYTLKLEKEHEQALLIYTHKLDKEHEQAQLIYTHKLDKEHEQALLIYTHKLVKEHEQALLIYTLKLEKEHEQALLIYTQKLEKEHEQTLLIYTHTIRERTRASTPDLHTQVRERTRASTPDLHTQTHVTHGGKSVREEGGQGPQLLVKGSKVLHKTYPHGGVQGGTQDKFGEELGLLRAGRRQGQGRDMLQGNPEMQHTESAIMGAMGMAAVIVEASTCMNQTAAESDTLIPASFTTLELTVSLILAVLLKPFKYGNGKLWLGALFRTRYWTDILKQGGNAADAAVAVAAALNLTEPSSTGIGGDAFCLYYDSKTKKVHGLNGSGRAPGKLSLEVLHKEGYNVDNPLPVNHGHSVTVPGSAAAWCATIEKFGSGKGVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DL90</accession>
    <name>A0ABY7DL90_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_029543</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1390">
        <property type="entry name" value="ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039788">
        <property type="entry name" value="NOL4/NOL4L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12449">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12449:SF18">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Roc" evidence="10">
        <location>
            <begin position="138"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="399"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAQ96853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="951" mass="111418" checksum="17105F22F294416F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLI6</accession>
    <name>A0ABY7DLI6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LOX5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_022587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00113">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052970">
        <property type="entry name" value="Inner_ear_hair_cell_LOXHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901:SF3">
        <property type="entry name" value="LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901">
        <property type="entry name" value="PROTEIN CBG12474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="2">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ98214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="160" mass="18994" checksum="475D5080AB5CB7F2" modified="2025-10-08" version="1">MDPVDYVFQVRTGDRKFAGTDANVKVILHGDGGRSTEKMRLRNTFKDDFEQGHLDTFVVKKQFKLRKIEKLELWRDNFGLGSDWYVDYVKVRRKDLEHEVVFPIFRWIPGKKHFRFRVNDTMLPQQDPEAEQRWEELKGKRERYIVAQKIPNGPAQALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMX4</accession>
    <name>A0ABY7DMX4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Guanylate cyclase soluble subunit beta-1</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Guanylate cyclase soluble subunit beta-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Soluble guanylate cyclase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MAR_023410</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">MELC-2E11</strain>
            <tissue evidence="18">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF2">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="363"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WAQ99037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="553" mass="62717" checksum="2D73D9BCEEE5D040" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPQ4</accession>
    <name>A0ABY7DPQ4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PRT1B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_023757</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD225/Dispanin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051423">
        <property type="entry name" value="CD225/Dispanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948:SF25">
        <property type="entry name" value="DUF4190 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948">
        <property type="entry name" value="NG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ99384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="165" mass="18231" checksum="D96D3A814B50FAA1" modified="2025-10-08" version="1">MENAGNIGYNFSNLDNPPPYEPPPQYDGQQYKRDQNFRQPYPGQHQDAGQHPYTVQQQYGLQPYGVQTHVQSPTTVIVSQPEVVTTVSLPPDYLVPSVFACLCCFPLTGIFAIYYATVANSASASGELDAAHRYSNSARSLMITSIVLGVMWIGIFIALWRLGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQE2</accession>
    <name>A0ABY7DQE2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CO6A6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF84">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="36"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="221"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="421" mass="46355" checksum="7C340E88400FF355" modified="2025-10-08" version="1" fragment="single">TVSTSAQEVTATASIRPVWDTIADLAQAICQPIMADVIFLLDSSISMTAGDFRKQLDFINRFVDHVVVDEKNFRVSVVTFSSKAQLEISLTDYSDNVTLKKASRRNVYTSWVGEDQTACQRYIAEANTGKRYVFLLTDGMSSYRQSTLDAAAELRNFVTKILAIGIGSEISHDELLGVASPGDERAPEYVFSLHNFNALYTIIQQLVALTCDECLWNTSSDVTFLLDMRSGITDLHFSQAVDALTYLLSDTLNKNYNVTVRLALLSFGDESVQIHRHLTDTASTDSLIQYIQTLTVSRSCEGGSAELCGSSNINTLDTALHDIEQGIFSGSKNETRQTIILFTNGDLRIPTGSNSNHARLKESGKLILVVGLGEEFKVGSVQGLVSDPAYVYVSRSENSFRNLDVIATEILHTSCELTNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQQ9</accession>
    <name>A0ABY7DQQ9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ILK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_024424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF57">
        <property type="entry name" value="INTEGRIN-LINKED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="236"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR00052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="518" mass="58938" checksum="A8C8B145951B3715" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTF8</accession>
    <name>A0ABY7DTF8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="180" mass="20015" checksum="D92C3161DEDFD661" modified="2025-10-08" version="1" fragment="single">MESKGNNVVVEKRGLVVCKDYQGIGASVDGIVNDLTTGTSGCLEVKCPMSRKEMTIAEACDKTPFCLVKDSSGQMLLNRAHDYYIQIQGQMYVLGLSWADFVNSVKLLPVNRSLCIRERFGRFCFRSYMMDRVRVCDCPRTKKELGNQFMTSTVSRVSAGFGQLKALVLWSSIGSVELKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUM0</accession>
    <name>A0ABY7DUM0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HISAT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056483">
        <property type="entry name" value="Hisat_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47403">
        <property type="entry name" value="LOC100145250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47403:SF6">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24066">
        <property type="entry name" value="Hisat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="92"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="405" mass="45329" checksum="DA00B30D59C66178" modified="2025-10-08" version="1" fragment="single">LELFIGDGDGELLLAFLRGVAFFRGVAGGELMGDSCICVTFSGVHNSAAFGVESGVKLTGNKHVDSSTSNLNFTLPEGSHVINVMTSTEDNVLYREATADDKTAVIDIRRNVYDGIDYLEAYYDAFMAAETITCYVAIFQKQVVGFCAAMLLDGGKTFSPRAARVSPMVEGTGVYFALKNYAARQSGAKREALTASDINPNIRKESFKNAYKFVLTRKFIRYKIDADVLKSLQIPKLTGPVRQIDRQAFTEYMTTPVTSGYLFPAGRVIIDWVPFRLLPENFPVLESFEGNKCRIFSSMTPITPTNGLVTINTMYKTSQLKYHCNIDIYGTKVDSLKDHMLQNLIQIKEADCDTTSLIVYTPMDFDTEYLDKLFIEFGLPRNDWIFESLPSENVLELYLYEKSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUY5</accession>
    <name>A0ABY7DUY5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="232" mass="25371" checksum="29F42F7C9FC1567C" modified="2025-10-08" version="1">MEKGGTPKKDESISDILAAADRKTQQNGYAESSKNTHETGDSARNTQEDNRYSRETDLVNGSIRHNTDRENLPVTDEVKLQSEQDTTLSSGTDKRKPSISQSDGDTMNVNEVYEGQLDLSNPDSVIHMLENCDLTEEDTENLLQEAYSMNRKLKEMLRRQDADQSASGKTKSQKPKPKNKPSQGSSAASSSSGSRVGSSFGSRKILPPIPGETRDGVTYKAEEGNGAKGRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DV59</accession>
    <name>A0ABY7DV59_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_008138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="18"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR01580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="114" mass="12471" checksum="5A759EFF18735EF0" modified="2025-10-08" version="1">MVREVAPKTENSPRQRRSKVCSSTQIGGITINLVTEELAKFEADVLVNSTSPNLQLKSGGGVSASISKEAGPAIEDEIRRKYPGGIEVLEFAETSGYRLKCKKAFQAEMLNRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVK0</accession>
    <name>A0ABY7DVK0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_008286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="31685" checksum="82B127C3DF5DEEC6" modified="2025-10-08" version="1" fragment="single">MDWNTMSPSPDRKHPTYYRKILETINDFNLTQMVNLSTRENNILDLFLTTNPTLVNILPGISDHNIVEVKVHTSTKICYQKPLKIPLYKKANWERFKQSMDTYHQEMLKEGKYSTLSIEDLWVNSSSTLNNLSEKFIPSKMSPLDAIFSGLIKRIIRRRDRAFKSFRKSNKSSDRKYFMVLKHTDSLNVNQPDASPSSKPNTKKFYSLLKHSKQDSASLPPLKYRNKLYTDETSKATALNKQFQSTVKITKECQIYISANGIEKLLTNLNPHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVL7</accession>
    <name>A0ABY7DVL7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_008301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="3">
        <location>
            <begin position="13"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR01743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="366" mass="40933" checksum="F4E102D04E29C2AF" modified="2025-10-08" version="1">MYGFTNCYPCVPCQRGKYREAGSRSEVCNYCNKNCSVVFRYESMPCGGSSPGHCGQCFTGREPEDEMPESFCKEPVGKTTAPSTTKELVGRTTTSLNEASDVPKKSIDSAGVAIIMCTAVLICVAFGAGIYHFRKDICRRCNCVSEGDYFGSQESKRPLKSDCSLEIDGPNSPCPELESHPVDFGPPALEQIRTYMPDFKLDVESESTKKCLIIVSTKASNEHKRNTIFVYLRIEKAVYEPEEERWLKEKQSYPEFVYMVLKTWVQRDHHPTFLKLYDAVRKADIGIAEELLESVHIQYPVEEGRISSERDAERELVPYTGIPILSRSTFQFTSIEIPAPSTGSTGSDAQYVSSDESLVLKTPNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWI2</accession>
    <name>A0ABY7DWI2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCD42-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_008635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051147">
        <property type="entry name" value="CFAP_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025252">
        <property type="entry name" value="DUF4200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13863">
        <property type="entry name" value="DUF4200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4200" evidence="3">
        <location>
            <begin position="35"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="35"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR02077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="312" mass="37093" checksum="3CAAFCBB97485598" modified="2025-10-08" version="1">MAVSLEEYFRTTFEDKLLVKMPEREDDHLTPATRLLEKRREMAEVEQALAAQKEEFQMKMESLQQRREELERKEYQLKKSLLQFDKFLKDNDSKKARAVKKANDEREMKRQKEKEIEKLKVETDDFNKNKEKLKRKLENYSVFHKYMEKALERGEEFHEMRDVIARYDTLTATHEDLLKSDQKNQDVIERHRQNLMKYVEEKDNEILGFNNQLSSLQTRLDDAQSDAVKWESQWTHIKNTAAKKTLELGRIKMATHNLYQLVKRHQKQAAGAEETPDQLNQIQMFIQDLTLITNEIKRMELAGTSIIPPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWZ6</accession>
    <name>A0ABY7DWZ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">STYL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053272">
        <property type="entry name" value="STY_interacting-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46659">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46659:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="199" mass="22699" checksum="7A37C995145EFED2" modified="2025-10-08" version="1">MEGLVLLEPTELYNMLQQASVYSNLSDNNYLLLIDARNKDDYNESHINKDGQFFVPFDSELECRQNVVVYDSNTCSELDEIKPYPAEIITGFLYLGDWRQGNASYVQKDLKIKAHINCCVEAETFFPANSGHLLHIQCDDSSDADLSSKFEVACKFLDSCQEKNKPEAFNHVKKCSNYIQPVQAFMDQLKTWSAKVLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DY00</accession>
    <name>A0ABY7DY00_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="133" mass="15054" checksum="AA33793221C0889E" modified="2025-10-08" version="1">MSRKSEYQYELQPVPGQEERIYHGIGNQRSGVVGNERGVGFTIGIEEATMGRGKDDKVPARLKNRARSKPTILSKEKLDEKQKLAAERKKKADAEKVKSSRKVSQSTFFNDPSSQPSVQPKWFEKGLDKTLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZJ8</accession>
    <name>A0ABY7DZJ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_009498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR02940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="466" mass="54717" checksum="EBD5CEAA924040DF" modified="2025-10-08" version="1">MRTIYRKAQFGDQPYGGFLGYGRGGFGMPRFPVGRQTFGYGPTSPGPSPYRPYDARVSPLPDFKRSITPSVQPWSGQAPSAPIPSLGTRSYNPSGVGTASRFPGPYRDSGKSAYRLPLVVRRNFEPSRPAYQPTTISPVTKRPAQQMSRGIYGSSYDMYDRIDDRWDRISDAVDNRFDRISDRIDNRMDRVSDRWDRVSDAVDNRLDGYSDRLDKRWDRASDTWDRVSDVVDKRIDRYSDRVDNRMDRVSDRWDTVSDVVDKRIDRYSDRIDNRMDRVSDRWDTVSDVVDKRIDRYSDRIDNRMDRVSDRWDTVSDVVDKRIDRYSDRIDNRMDRVSDRWDSVSDRVDSRLDNISDRVDNRYDYLSDRIDKRYDYRSDRVDSAYDYLSDRADRQYDYLSDRAGSRNGYTSDRMDSAYDFLGDMADSRYDYLSDRADRRYGYDSATKGVRANAYDKALSRGYYKYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1D1</accession>
    <name>A0ABY7E1D1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="65" mass="7244" checksum="8748296219DE3E81" modified="2025-10-08" version="1">MSILNRGRLKSACTHQAEPPIPEHSRRQWLVTGSPPFCGPRVLKAPIVVAVRVITEVFPLWVWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1G3</accession>
    <name>A0ABY7E1G3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="7">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_025373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>alpha-D-galactose = beta-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:28675"/>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:28677"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="7"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR01001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR01001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="269" mass="30116" checksum="A742097817595444" modified="2025-10-08" version="1">MGFDSDAKKSHVRYLVLLPNSYSSHSGGSSYRDKSATVTSWKHEGEEFLFCSKKAVLDGSKAIRGGIPIQTLDPGSWVPSMGLPESRSGNRPPTPGMVKMGLSVWTSPWKMMIRQDKCGTRRGEEFDFTTLLHTYVRVEDIMTTTITGLQNCTYTDKVHVGEHVEEREAVVIDENYDRIYQAVDGAVNVNQDMQTLGTLRIERDNLPDVVVWNPWQEKAAAMSDLVPMEYLEMVCVEAGAVTSRVVLPPAQQRTFSQKLIICRGQQVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E442</accession>
    <name>A0ABY7E442_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR03737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="86958" checksum="8DC853FAD9ACA41D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4P9</accession>
    <name>A0ABY7E4P9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DC1I2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_020352</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR04983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="545" mass="60891" checksum="26F04E238EB038BD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5P6</accession>
    <name>A0ABY7E5P6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR03871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="221" mass="24918" checksum="03C7A35019665B09" modified="2025-10-08" version="1">MANLIQISLVLVFPDQLSLKIPVFRTASGMTIEPMHNNRSCLPCKSTFDHPLSYEFEKEVSIVTLVMVDLYFYSVYILSGLLGAVSSLTAVADDVINAHPQQKLEECSMMGPMSDSICDLFLLDKSLAGEEAVQTVVHRPYLEDLLQKQKLLDNILEMVEKSKEGVQMGRKRSCNVNLGFHCQTEQYSAIADMYNWLQSSLSPGKRRKRRAAAYKNLPHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5Z5</accession>
    <name>A0ABY7E5Z5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_020819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046526359" evidence="2">
        <location>
            <begin position="24"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR05450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="239" mass="24645" checksum="0D71D85EFFCF7A20" modified="2025-10-08" version="1">MCSTFSILVLSICVALTVDYAGGMTTGPPVGGAGTTGGMAMTTAAGAAAEAAEPLEMEEVFTTTASTTTTTKKPPCKGRGKGRGRCKGRRRGRPKNLKPKPGSVKPKPKPTPVTQAPTPAPTPAPTPAPTAAPTQAPTYAPAPVYNQPAAHAGGVGTVGAAGGAHGGMVGPSVHVVPQMNPYPNNVVTPTPTTKRPNQYLYEPHSCPKMDVATWENEVVIYDNKNCAIRPTVTFQAPYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6B4</accession>
    <name>A0ABY7E6B4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="13112" checksum="FE6F0D28D68B84A0" modified="2025-10-08" version="1">MAQSYYSSNQQWAMAIENCFVGKQFPATIQSIQNAKFTEQNAQNYWTGILKKESIMSKTDMSDISTNPPMAFAYVEQKKQTFYVRFANEGDSKRSLCSGDNDKFSKCEVELSLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7J9</accession>
    <name>A0ABY7E7J9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="109" mass="12591" checksum="9EC5D7B894271BEE" modified="2025-10-08" version="1">MYLKCHQRHQQKHQDYKKPGETKKKPGETKIKPDETKLVADRQRENMNKKQKHSMSSLPSPPPPPPPPPQGAPPPQPPHLRTVFPRVEFVQGIPMDLEDDDFFDPKINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7W8</accession>
    <name>A0ABY7E7W8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_020020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045268549" description="SRCR domain-containing protein" evidence="4">
        <location>
            <begin position="17"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="5">
        <location>
            <begin position="26"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR04651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="401" mass="45494" checksum="A234D18CD3A62AEA" modified="2025-10-08" version="1">MTCFVAILIWISYIFGSFFCEAASCFQLIGGAQHNEGFLQINVTNAWKYVCLNDDLNDKDIRREICYPIRSQTKAVAKIKEPLLYENKPGEGNITINNLSCQTTMEETDSCPKFIICCQDEPMSKQLSLCSSNWLETKYCYTGKVVGIHCFLKYNDNQNVSRAWTSSAFKDLCKTNTSYSVTTANKLNMCLRTIHTQPDTTYALIEGDNCEWTKGITCDEKVRTFQLVENNIASMDDLHCVTVEVQNGTSNFSIAHCSSYLPAVCLDVEQEIDKKCSTLETTTNSTKNIRSLTTPSSNEKESVWSQYVILASVPLIFILVLIACFHIRKSRKRLIERQRPNSVQNHSYGRGEIVEESTEETYNIINDCELKDFKPELPARGQNNQILVLDDYSMPAEDGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAQ0</accession>
    <name>A0ABY7EAQ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SEM5A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_019610</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057563">
        <property type="entry name" value="Sema5A/B-like_TSP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF79">
        <property type="entry name" value="SEMAPHORIN 5C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23260">
        <property type="entry name" value="TSP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047273396" evidence="11">
        <location>
            <begin position="27"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="12">
        <location>
            <begin position="39"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR04241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="939" mass="106892" checksum="8FA3527D6202A0F8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBJ6</accession>
    <name>A0ABY7EBJ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="33" mass="3756" checksum="6D33C7C9CC5A9217" modified="2025-10-08" version="1">MPTEYADIEFSSTQEPEIEECACQNASDECKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EF34</accession>
    <name>A0ABY7EF34_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="90" mass="10885" checksum="EF1B23EC2E8073C1" modified="2025-10-08" version="1">MYKSDIEYVTEVDFVEVLLCQWRPVIIEDNLMKAFQFRNNIPPPLTIPIIQMFFAQQYDRESSTPRACETWKEKMEERNVDQLIREKEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFM7</accession>
    <name>A0ABY7EFM7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="170" mass="19275" checksum="1FF6EDF0856D7A78" modified="2025-10-08" version="1">MKGCFAKDATVPVINGAPKFSAGLGYQLKIKQLEEENRYLVTAIADVADGDSVALQKCKSYSYYLKNDADDGTTVLNNVNETTTRYAVFWSSDVDHYTLMLRCFIKEGLPEPRTCKVEDTAISLFVPDTLDNLKWSKVLKDLEETDVEFGNERFEWFFNFNYGKSTCVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFT0</accession>
    <name>A0ABY7EFT0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="437" mass="49080" checksum="610A2B75FBC00E8C" modified="2025-10-08" version="1">MAGKYTLDVNQDVFSDFPRFISARTYDSVKNQRDFWKHKNGRFGTKCYCGTSEKRHCQSLESPAVMPHNSVTKPEIKIPVSARDPEEGDLQQVPEPTPVVPKTTPSHTTLTDKKPEVDEPIEEDQSSPTAATPNPLKVSVHWGPSSYTPSGPLSNSPMVHPLISRGQSSNTPCEPLSDSPCRPLSDTPSGPSSDTPSGPLSDTFSGPSSDSFSGLMHIMYSQLQTQLPKQFSQNQEKFIKQFHIFSGEPLEAYNKINFQRLHEVIRQYVELFQTVDRSHRGKIGLASLQEILNTALARDFKVEPHNWHKFIDNLQLSKLQNCVIYDQYTHTQHKAEKPKCHNKDPFSAILGLEISCSHAYQNPYTKANGQQAPQNTDIRFVHISIHIVNFSQNIHHHSADGKIHYPQVIAIVVSWGWQSCSLAEFFIGRVKVSKKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFZ8</accession>
    <name>A0ABY7EFZ8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12662" checksum="786C72AAE03947F1" modified="2025-10-08" version="1" fragment="single">MNTYISLYQNEWLLNIFLCNINLVLTFHLNYLQCRSIGEPMLSCSVVDEAEVDYEVVEEGSNRKRQKLVSSDGFSYCVKRETDSSRQWRCSIRRKDMSCYASVNQRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EI12</accession>
    <name>A0ABY7EI12_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="155" mass="16899" checksum="D8363439A94F1F5E" modified="2025-10-08" version="1">MAVGVLFSFQRLDTIEGDFGALSERVSNLESLMKSSDNNTGGTDNPTNGHSKGTINTQSTFDDIKTTLQMYKHSFQKQKKELVNANHDVKDTLSAFLSNASKTVDTLVNTVSDHVRNSAKNVSASLEKVSDTLVVKRLCNTGTCPKRNDSARKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIG0</accession>
    <name>A0ABY7EIG0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DHGL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_034854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047234184" evidence="6">
        <location>
            <begin position="20"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR09778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="606" mass="66761" checksum="E79662C5E3574E7D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIP3</accession>
    <name>A0ABY7EIP3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTPRB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="188"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR09010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="395" mass="45003" checksum="47425C619938C562" modified="2025-10-08" version="1">MWGIVVAEADEAARDSAFAGSRDDFQKKIGDTYKTWFQVDGLNNIPPYIVTKPNWRPPCTSGIWRKRFATDGSNIFVIGNEECYGSSVSKHYCNGPLPDGRSFKVKSFVCTDYGCSESVYSQPIETVKSLVRGTGLVVATYMTGAIVGGAVSAVVVLVLVVLMIFFMRKKHAACFKKDTESITHTSSDRFVELGEIQTKAQPGAVYLQGPVNLTEFPAFVEKMHKDNDLIFADAYKGYTSLREYIATQGPMQATFDDFWRMVWEQNVDTIVMLTKLVENGRIKCDKYWPDVNKPKYYGDLLVSVASESNLSDYILRIFEIKLNGERRSVRQFAYLKWPDMGCPELPEMLLEFFEDQFIFIHECLKACITSDRNYEEVEEHMYEQLTNLGRQHQQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJ31</accession>
    <name>A0ABY7EJ31_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="190" mass="21692" checksum="C4D1B819A60A041B" modified="2025-10-08" version="1">MEDTVHENHTRSISYETSVLVGQVTGLQDSLVTCAVQNGVLQGIISSKGEETLYILPTTWVLKSPSIFWSVIYTEHDFKRDSLLHQFIRNHHKSYISLQNKIRAVNEIHYMIRDHLKVLNDIFEEAMFTVNKGTAGEFTFSGFQFEKAQTLHDNNETACGEYSVLNEPDAGYYLMHEVAVTGDLENNFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMT4</accession>
    <name>A0ABY7EMT4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_034785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR09709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="36127" checksum="14D8FB6EC6E0FCD9" modified="2025-10-08" version="1">MDAALIDNKSSNAVDTQSKDGYDMPVYGIENGSFYYVHVPAIVFIVTSFTCALIAIICYFRNQDYKSFFTRWTKAERLIVYLSTCDVLFSLSHLMDHLHMVIARDHVRPKQLCSFYGFNLVVFVAAQILIVNVVAFNAFMMMYFHKNMHFGNRDWKLFLWTFVTHFVASIVAANFGQFGPNGTAVLYILTFAKIKQEVRTIEKGLGAQSASRKAPIRAARTMSMFVLALAFQWWAVAVHGVWRMFTESDEDIPKIMYHFTTTFSNTGGILNLVIYMFIRKKKLGSRDATESHYKFSSHAVDKNCKDVAAIAHATTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPD0</accession>
    <name>A0ABY7EPD0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="93" mass="10813" checksum="D1B5D1B959543824" modified="2025-10-08" version="1">MVYSCAQCGASFYKLNPANFYNIEKTGERRIEKFKTTASYFTVRIKDLEKQLLSTILKTLNTIFQSILEHITEMILSTYLVRLLSKIPNWIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPP5</accession>
    <name>A0ABY7EPP5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="3">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_026140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="3"/>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056586">
        <property type="entry name" value="EF-hand_PLCG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057061">
        <property type="entry name" value="PLCG_EF-hand_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF159">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23329">
        <property type="entry name" value="EF_HAND_1_PLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23583">
        <property type="entry name" value="EF_HAND_2_PLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="355"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR11960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="451" mass="51895" checksum="4C505A9310CCDBA3" modified="2025-10-08" version="1">MAAPSLSWTEGLPDTQTMHLIGDLENGKVVTIFFSKTRPERRTLAVKQQTSQLVWIRAQGVRPEGATAVIRVASGLEKSGKLVDSSDERENWFKGLDLLIQEAKSASHTLVVERWLTREYNSILERDGRVTLKAMKSWTTKINCKLTTNKLKEKYQSVDKEKKGAIVQEEFTQLYHFLVHVPTESLGQSEVKEVMKNFLSDPGREIHNKLFFTEQEFVDYLFSGHNTIWDSKYNSVTQDMNRPLSHYWIASSHNTYLTGDQFSSESSVEAYARCLKMGCKCLEHTRDGDLSNSVKNGILYLEDPIDNTWTPHFFVLTPNRMYYSEETNNAEEEEEEEEENGVRKEMEYLNKPLPWYNSNVDRDQAEEMLRRIPYDGAFLVRPSIPHGCGDPGTSPTFAISFRAEGKIKHCRIRQEGRLFTMGDAEFESLPELVRSPQSRDFMVYVDRPISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQC4</accession>
    <name>A0ABY7EQC4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAPEP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_026367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="95"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR12187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="498" mass="56481" checksum="D7D0B3A938381942" modified="2025-10-08" version="1">MAEDSDVPEKFLTKKGRISFRCGWKAFSRPGPLLLLDWTLEPNNSGIPWNDLQAIQRVHPVLDYDFQKVNNPPQDKIQITWIGHATVLVQMEGKNILADPVFSEKCGPAGFGLQLGYTRFRCPACQVEDLPPIHVVLISHNHHDHLDSQSVRDIAKHHPDAKWLVGSGNAKFCKTSGCKDVEELKWWEPKTVGAFTFVCTPTQHWCLRYPDGFNHALWCGWVVKSPNFKYYFGGDTGYQDELFKLIGRKYGPFDLAAIPIGSYEPRYITELERVNPEEAVDIHKDINSRVSIGIHWGTFELTNEYFLEPPQRLEKEMYNRALDPKTFFNLRIGETWVVGENRDYNPPFMEREKEGTPRLTNGPFDGDLSGYKRETALQKCESDHLHRTHRICQDIKTKSEVQQTERSNPKRISADEPSPHNNHADSATGMKPTGRSKPRRSLSPDAPSPSNNQDSASGIKLTGRSKPRRSLSPDAPSPRNNQDSASGIKPTGRSARDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERB6</accession>
    <name>A0ABY7ERB6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZG57-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_036347</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="765"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="793"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="821"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="849"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="877"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="904"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="932"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1378"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1419"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1447"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1474"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1503"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="451"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="533"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1209"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1519"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1630"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1585"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="535"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="614"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="633"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="655"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1216"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1238"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1262"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1281"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1519"/>
            <end position="1535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR11271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1687" mass="191670" checksum="01027CE18943552C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESV6</accession>
    <name>A0ABY7ESV6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="135" mass="15145" checksum="C3221BB423ECB379" modified="2025-10-08" version="1" fragment="single">AGLDNDRIILALEPETASIWCQHIDTSLKTDLSRTGSQYMVVDLGGGTADISVHERNTNGTLKDIYKASGGPWGGTCVDRNFISWLTIFFGETTLSRFREEDMEDYFGLLREFETKKRTITPDTDGFVTFRLPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EV99</accession>
    <name>A0ABY7EV99_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tox-ART-HYD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028920">
        <property type="entry name" value="Tox-ART-HYD1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15633">
        <property type="entry name" value="Tox-ART-HYD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tox-ART-HYD1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="126" mass="14635" checksum="A8B64F2E8F8CEB68" modified="2025-10-08" version="1">MPKVLYHHTDLMSTLHILMSGQINKSTDPKHARFGPGVYLTEINQYASVKEILINNYDDAASKKKMEKLIEKRGERTQVCIELKISSRLFKENVEECDTKRNVFLYKGDLILADMDDVSYHIRDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVB1</accession>
    <name>A0ABY7EVB1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KLDC4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="581" mass="65096" checksum="65B365C5F9D7EC42" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVP5</accession>
    <name>A0ABY7EVP5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34284">
        <property type="entry name" value="FG-GAP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34284:SF1">
        <property type="entry name" value="FG-GAP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="330" mass="37903" checksum="88D65773A8C90B72" modified="2025-10-08" version="1" fragment="single">DHHSQCLLQEEGQEHHWKLSLKRHRLHIGESPWTYYKSELFKALPHNWRSVRDTKFSLGYAYGGQRPHSDEEHIVNPNAVVINHQNGVEVLNLVSGRPVTRLQLPDDGAIYGVVDAENDIKKLSWGEQENYSPCFLDIQRLFPIKENLERFPVCVTRRMFFTTNWVYDEDMFVKIPPVIIKSVARKSGVVRHLLGHHLRKEMDTYDLIALGSMGRITSVDKNGDFNWQTQTMANWDSVALAVRKMKKGDWTEQQHEFLNSFYPDRALMPLQLYGDKVNLLSVGWSGLSLIELTEGRVLAEHSTPCPSTGPLVVGDFNNDGYNDVIFTCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXP1</accession>
    <name>A0ABY7EXP1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_026131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027897">
        <property type="entry name" value="DUF4559"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15112">
        <property type="entry name" value="DUF4559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="386"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR11951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1219" mass="138544" checksum="D2927E94026DAF00" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXW5</accession>
    <name>A0ABY7EXW5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF6">
        <property type="entry name" value="RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="180" mass="20305" checksum="0E00FB904670A9FD" modified="2025-10-08" version="1">MSLATCLTTILFIALANILNMVMHRLICLQQENMENLSLDAFLVVYSITDRSSFDLAVEVLKQLREEVGAYKAIILVGNKSDLVRKRTLSADEGRAAADGYDCKYIETSAALNHRVDELLVGIHKQIMLKFQSVSSEDQNNHVAKLKTRKSSFKKTKRFLEKIFLGSSGKDKKTENLYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EY08</accession>
    <name>A0ABY7EY08_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_004928</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="6">
        <location>
            <begin position="64"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR14823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="279" mass="32146" checksum="EC5ECBE6268BF22D" modified="2025-10-08" version="1">MYLGHDYTGYAGTEEAEHTIERELFEALIKCKLIESKESACYSRCGRTDKGVSAFGQLMEEAGKKLIGEYDFRNFSKFNVKNGITNYVRKIMEVEVKTLDETDDGFTMYELTIVGRAFLWHQIRSIFSVLFLVGKGKESPQYNMSSDAPLCLYDADFGGEFEWIYEAVTLDKMIASHESRKQRWRENAEIEVQDDSSEEEMTSRKRQRLEIDKPSHIDDKPFGTLHKPKSGENKDPHINYEENNKEDDDTVRDIDGETTDMKADKDICDSKTSLKDKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZ29</accession>
    <name>A0ABY7EZ29_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MDR1A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_004206</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="769"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="47"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="296"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="593"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="847"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR14101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1057" mass="116460" checksum="14B374F1272E39DE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F026</accession>
    <name>A0ABY7F026_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TRIM2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_005635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF25">
        <property type="entry name" value="PROTEIN LIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="279"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="313"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR15530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="417" mass="46373" checksum="84B92F0EE13F566F" modified="2025-10-08" version="1">MIGHSYSFGCVEQQVANQNSRYKGSPLDEWRLARPEDERSPMSIRRHPCKQRVTFSDVFAQSKDYGSINIRQGKERLDAVTAINETDIPDDIKNSINGDDWSLVTSSSDNSMHKGHSNQTFSHDPGDISRGEEFIRAFGEKGKGIGDFEDAKDVTFFQGGKLLITDFVNGRIQMCNVKETAITVIAPDEINQPWATCVLDGDKIAVTLCKRKQVLILSKDGEVLNSFGEDIFVCPSGIATDTKGRLIICDTGTNKVSMFEQDGKFVRHLGNPDTKDECFSTPRYVCVSVNGNIIVSDSGNHKIKIFNSNGDLINSFGSFGKGDMQLKYPYGVCSNIFGDIYVADHYNSRISIFNRDGEFIRHLLTGKNGLVHPQGLTISPDNYLYVTHGHLKATEIVIFKLTFKSSDKSDCNIISYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F098</accession>
    <name>A0ABY7F098_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">VIGLN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_004864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd22405">
        <property type="entry name" value="KH-I_Vigilin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22414">
        <property type="entry name" value="KH-I_Vigilin_rpt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22416">
        <property type="entry name" value="KH-I_Vigilin_rpt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22417">
        <property type="entry name" value="KH-I_Vigilin_rpt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22418">
        <property type="entry name" value="KH-I_Vigilin_rpt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22406">
        <property type="entry name" value="KH-I_Vigilin_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22407">
        <property type="entry name" value="KH-I_Vigilin_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22408">
        <property type="entry name" value="KH-I_Vigilin_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22409">
        <property type="entry name" value="KH-I_Vigilin_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02394">
        <property type="entry name" value="KH-I_Vigilin_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22410">
        <property type="entry name" value="KH-I_Vigilin_rpt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22412">
        <property type="entry name" value="KH-I_Vigilin_rpt9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057778">
        <property type="entry name" value="KH_Vigilin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF31">
        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24668">
        <property type="entry name" value="KH_Vigilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="44"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="122"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="194"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="267"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="336"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="394"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="466"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="583"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="656"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="726"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="819"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="899"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="972"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="765"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1055"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="780"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1059"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR14759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1123" mass="125495" checksum="CF110EBE6EE2D387" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0F1</accession>
    <name>A0ABY7F0F1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ELYS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_005768</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032040">
        <property type="entry name" value="ELYS-bb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052620">
        <property type="entry name" value="ELYS/MEL-28_NucAsmblyFactor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583">
        <property type="entry name" value="ELYS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583:SF8">
        <property type="entry name" value="PROTEIN ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16687">
        <property type="entry name" value="ELYS-bb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS beta-propeller" evidence="5">
        <location>
            <begin position="39"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="ELYS beta-propeller" evidence="5">
        <location>
            <begin position="199"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="ELYS-like" evidence="4">
        <location>
            <begin position="629"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1022"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1050"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1128"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1198"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1372"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1452"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1649"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1792"/>
            <end position="2169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2206"/>
            <end position="2229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2245"/>
            <end position="2277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1050"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1128"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1155"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1198"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1210"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1238"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1284"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1296"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1386"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1452"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1492"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1512"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1665"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1746"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1833"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1950"/>
            <end position="1960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2006"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2041"/>
            <end position="2058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2069"/>
            <end position="2080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2255"/>
            <end position="2277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR15663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2304" mass="256531" checksum="69686B562C9C5C1B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F193</accession>
    <name>A0ABY7F193_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TENX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_030539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047351755" evidence="2">
        <location>
            <begin position="26"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="449"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="482"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR15945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="546" mass="59752" checksum="7CF567A507B494F2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1S1</accession>
    <name>A0ABY7F1S1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_030722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="135"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR16128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="604" mass="68892" checksum="23D4876794A2F9FC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1S9</accession>
    <name>A0ABY7F1S9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="76" mass="8792" checksum="646109627388FAFC" modified="2025-10-08" version="1" fragment="single">MTPMLQFMEGLKLHGILQLLQANQEEGLTILSSGSKYPSPDEVQELYTINYSTGQEEKEIEQLIVYNLNRFLMRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F271</accession>
    <name>A0ABY7F271_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="106" mass="11734" checksum="A6D5D99A2848DDE3" modified="2025-10-08" version="1">MTEEILSDENTNEDDFLPFPHLLTEKDTISDELTNELTHVSSTVKSTLTIIVQIELYDHAGYRKSSGGEVVKVIFTGSDLTNTPVTGYVIDNGNGSYTAEIEALWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2E8</accession>
    <name>A0ABY7F2E8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="56438" checksum="DC87A9754518936E" modified="2025-10-08" version="1">MPANAPRLRFEDLLVGDKLGDGGFGVVYKGNLKKDFDMLYVPYHARVKKVCYEIRAQICRNYKEDPSHYKEVYECTKDFDTQRTEEETFNQTTPWDSQPDANKSTTRVEHPEENLNPESGTSNEEKSIQEGEPTVQTQLSSSSDSSLATPDGNTERSLWSNVAGPVSQQSGLHCISYGSQNASTNLATPNLSCYGASNDQISNSNVTPAVTPQVNDEIALANYTQRLYVRDLTEGETGQTDMNHHSQDGGNPNIDILVDRITNTQEASRAYVEPQARVDRQIPEAGRGGNQGNPLEATWVGNNPNNQEENDMTMMKMSQMSDRVSVLPPEQLVNRFQPSTPYVDAQTGSHAGQAPRQDPQGHGSPFNAHATMNEQSTNARTAQNLQTRETNMAVSSSANQKSPSFQPDNTPVQRNTTNGIVHQAIGSSKGQFLPSYARQQEIFGQRVQNQHVSPPTFLNQPAPFMIMYQGIRRWQQRLGQEATVAAMAKALWEADRDDLALQLPEVQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4A8</accession>
    <name>A0ABY7F4A8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LAMA5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_031574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin EGF-like" evidence="2">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR16980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="283" mass="31462" checksum="2C9C4B3526713D88" modified="2025-10-08" version="1">MEQTALCNVAQVVREKSATHGTGNATAEIIFMCDSCINGIYGDNCVLQCSQSCEENICNIRDGTCNCRSNYSGEQCENCIRDRYGEGCTKPCSLGCLENSCSSTDGKCDCKYFYKGGKCDVCEDGRLSQREAQGHTDEQETTHPEMSYASKGQEVKNNTTKKYIHLSRLCTLQCRKKGHTLVPGQQRESRYGNRNQQPHTSYTENNAETGNKLYEDIASDTDDLTTVQENFKKETGHSVTKITQHVELVIIAETLEDGGLEIDEDDQKARGIATKFKEKGGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F6Z7</accession>
    <name>A0ABY7F6Z7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">R213A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF16">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="200" mass="23038" checksum="54E1E73D8861F1AD" modified="2025-10-08" version="1" fragment="single">VEIFLRRSMNEQKGKLHCLVNADLLDFDVSEAAGHFLEECVQEKNYKRDNAYRLFIICRRDNENRSPLVSSLQKYIRADIPIDEVKLSQYILSKFSLKQGADQTFASNVDVEKSNARAVLSQRAGVGKSLFVKRVDEKLRAHVETQKHVEFKRVTVPLQEKIVDLDYVTRSLIKHAAGPEIKTARLFHIDISHEVRHPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8A0</accession>
    <name>A0ABY7F8A0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="161"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="225" mass="25487" checksum="23DB588DFA7AED8A" modified="2025-10-08" version="1" fragment="single">MDVILRKSQNVVNEFQPLTLICDLMVLHPFSMINWISNGNTELSKGRYCSPEIDSTKDYNMSCRTHRQYNLTINNVTRKNHGDIWYCREDHFLESQSNDVEIQVKGTPDDASDDAIVTETKNETITQTDNTVTTKSYMALKGNTALIGTSLYCKASNDILPSFVEVTHPRTQFVTAYEDKIVYFECVTSSGYPASSITWYKLTNESEVITSADASITSEMKDRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FB53</accession>
    <name>A0ABY7FB53_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pappalysin-1 SD scarf domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058897">
        <property type="entry name" value="PAPPA_SD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25900">
        <property type="entry name" value="PAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pappalysin-1 SD scarf" evidence="1">
        <location>
            <begin position="29"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="152" mass="16856" checksum="AF8802387C81402C" modified="2025-10-08" version="1">MASYDKVTRLCSMKYGDSDDIVPVPDAIFHCSAYQIAGAPDVYPTYGDMSEAWAPRTEKRAEFLELMFLTSVQVTGIDIYETHLGGAVSAVKCYQNGGYTTLWTSPSIERIIFARIFQPQLATGCFSNRIKLEIAAITGWVNIDAVQLHGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FD37</accession>
    <name>A0ABY7FD37_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_000780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR18942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="545" mass="60803" checksum="DC2E441A832B4401" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEU4</accession>
    <name>A0ABY7FEU4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GMFB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_001237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR19399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="142" mass="16628" checksum="6AAF299AFA877EE3" modified="2025-10-08" version="1">MAGNLNICDISEEVKTKLKKMRFRKEKNVAAVLLKIDPTTRTVMQEEEYEDVTIEEIQEELNEHQPRFLVISYVRNHGDGRISYPLCFIYICPSGCKPELSMMYAGTRNILQKELGITKDFELRSTDELTEEWLDEKLAFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFD1</accession>
    <name>A0ABY7FFD1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPR37-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="221" mass="25149" checksum="47996DFB7F090641" modified="2025-10-08" version="1">MDENQKPALTSTDVQNTGDENEPEKSSPSFSKEEEVNKPVLDSDPETVTKIDDVTKEVLDKERIGSSESDQNLSNLEKKDKRKVSFPVDSKIVKDFLEPPDPWKNVPEWRTEDLIKAYKTSCERHGTKPLSKILKQLGGIENVGERYEILSLKGERLDMRQCESLEDILRHTPCLTFVDARSCDLNERVIPIFGRALRMGCFLQRLHLQSANLAGRALLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FG79</accession>
    <name>A0ABY7FG79_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018:SF1">
        <property type="entry name" value="TESMIN_TSO1-LIKE CXC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="257" mass="28904" checksum="D3BFD2E161D97D15" modified="2025-10-08" version="1">MYSDGISAPSKNPDIADIKSDKNSGIDSSDIYQHLQAAMKEFDSLLSAEVDLKSVVKSPRVNEVKITIHDAEINMKGSERTGDWLLHLQSLLEMLLFFAATGHNAYAKSTYIYLNKMLDLPTTHPQVYRKGMHVIRRSDRYWAGLSTDLIIEQMLMRSVKTVGGLTRGSGMDEAQRAQWILSRPACSEINYKMQELTGQKCESSEQHKESSESRKIRDNDDIQKMFACLVDRNPFMAEESLRSIASGEVESKCGQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIB1</accession>
    <name>A0ABY7FIB1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_002276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF147">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR20438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="96" mass="10801" checksum="1B585BAED03D44EA" modified="2025-10-08" version="1" fragment="single">ATPYVAPIPGGVHDGLVIHVKGIAEKDKNRFSIALQCGDKRASVPFYFNPRFNENQVIRNTLEKDSWGTEERQGGFPFTEGSSFDIEIHVNPQYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKW3</accession>
    <name>A0ABY7FKW3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MAR_036364</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF94">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="79"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="375"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAR22695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="406" mass="46992" checksum="F0C8B3497E2B4C35" modified="2025-10-08" version="1">MTFDENQPIASMAMSDNQVTNEYYQYDDDQYCHGTIDNVDGINFIHDDDDNFDLNFFHRVESAEVVYQARKRAKLVEKYLMGDLLGEGSYGKVKEVMDTETLCRRAVKILKKKRLRRIPYGEQNVKREIQLLKRLHHKHIVNLIEVLYNEEKQKMYMIMEYCADELQSMLEAAPEKKFPVWQSHLCLGGFFSHMLDPFSKDDICKTSQGSPAFQPPEIANGLESFWGFKVDVWSSGVTLYNMTTGVYPFEGENIYKLFENIGKGVFTVPDTIDNILASMLKGMLQYKAEERFSIEDIKQHDWYRKKFPRTCEKVPFPVHPESGDELRNMTVIPYVEDLHRGESSEDEEEYTPDQISIVPATVIEPILDGNAVAKEIAEDPIPDPKHKKRKVKSSARRFKFSACSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FL89</accession>
    <name>A0ABY7FL89_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="156" mass="17756" checksum="5A17AB8EC56B2030" modified="2025-10-08" version="1">MGKCYSTHERKQQQSTTTTDEVFIYNPSRLEPIREPPIGRVSSETNSSEMNTLENKSQHAFSEMITLEYKSQFACSEMITSEHKSQLDFSELNALENNSQDTDRLQGLVLSTNSRLNQRYFMVNVPIASGKRDSKRNFPNDNNYTPEGGVSTDSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FN99</accession>
    <name>A0ABY7FN99_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026053">
        <property type="entry name" value="HPS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12761:SF1">
        <property type="entry name" value="BLOC-3 COMPLEX MEMBER HPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12761">
        <property type="entry name" value="HERMANSKY-PUDLAK SYNDROME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="529" mass="58963" checksum="AE9A615DB2AD9809" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPI1</accession>
    <name>A0ABY7FPI1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FA5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR23234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="184" mass="18497" checksum="BBA49BA80DB33DF9" modified="2025-10-08" version="1" fragment="single">NSVVSDGCQNSVGPDGCQNSVVPDGCQNSVGPDGLLNSVGTEGCQNSVGPDGCQNNVGTDCCQNSVGTDVLAPMADTTVLAPMADTTVLAPIADTTVLATIADTTVLAPMVVRTVLVPIADTTVLAPMVVRTVLVPMAFRTVLAPMADTTVLAPIADTTVLAPIADTTVLAPMADTTVFAPMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQG7</accession>
    <name>A0ABY7FQG7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_038124</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041083">
        <property type="entry name" value="AAA_lid_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17872">
        <property type="entry name" value="AAA_lid_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="573"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6 C-terminal" evidence="10">
        <location>
            <begin position="790"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="212"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="432"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR24455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="876" mass="98169" checksum="3F5EC6200D59B964" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FR88</accession>
    <name>A0ABY7FR88_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GA45B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_038399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024824">
        <property type="entry name" value="GADD45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10411:SF8">
        <property type="entry name" value="FI09246P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10411">
        <property type="entry name" value="GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="147" mass="16519" checksum="AA12A87D5487DE3B" modified="2025-10-08" version="1">MKYYARNTSVDSVCDSSDSEMSCDEGMQEIEDSLYQALKEDRLVQGVFPCARILEQTPEVVTLCAIPEEQCKNISAHIQQKLIEAYCWENGIRVINVEESTLQNLAKQSKSKSDSKSVDFYCVLVTSSSDEHSQIDEQTETTADNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRJ9</accession>
    <name>A0ABY7FRJ9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">YTX2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_038456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF26">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR24787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="493" mass="57019" checksum="9C10925EFE6C27F7" modified="2025-10-08" version="1">MRNRSSDDIIADTNRALITVAETWPDVPVAFSSILPRKGTNPLVKSMNSAAKQINTNILRLCQSKKNFHYLDNDALVYHENKFNKSFYDPRDPTGVHVSDEGAEELYANFLAFVFDGESDELVEVPSTPGTGRKRGRGSKSSTPPSANRLQKQGRLEICKYFHKLFNWIKDNDYDFALLQETHCSTDFEAKIWSSQWNGNAFWNNGDSNSKGVAILVNKKVSYVCVENISHMIKGRFQTININVDADKTFTISNVYAPNNTVDKKIFFTEINRALKAIQNEKHIIGVISIVPKMKTVSIDIKEDESLPSMNQIIFNNELDIWRRRHPKTKMYTFKRNKSYSRIDYILTSKFIGNEVDSCTIEHFPLLDHDAISIKLVMETETRGPGLWKMNTSILENPEFVKRFELFWKEWTKQKCKFSTLTSWWEIAKIRIKEISIDFCKELNKSKTGIKQLEKTMEQLKQEQLTDDICSEIQLLSEKKSKIIIKIRQRLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUE3</accession>
    <name>A0ABY7FUE3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">5HT1F-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_038135</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF47">
        <property type="entry name" value="ECDYSTEROIDS_DOPAMINE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="51"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR24466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="389" mass="43855" checksum="2CC9885900155201" modified="2025-10-08" version="1">MAINFAAPNDSTTMTNSTNSELLDSLMDEMRAAVTPVSVFVGIEMVIGFFGNLLVLYVFLFRYHHCNFRYFVLSLACLDFTSTVTTMPAEILSQQFWYTYPFPTVCTIKSFFNMFTISGEALCLFVIAVDRHRKALVLCFFIFATAILITLPVPFLFGTHNDVKLYAGRNVTVRVCEKDMAYVNSNMPFNYALSVQGILATSLLIMFILYVKIFRKISGKKTNFKRDAGFVSNSDTPRKCEKRTSVFTINEVEMPGTLAGNTSDNTSVGYATDNDSACSDAKKTAAEPVKRTTRHHKSKMPGSARRKTYISLVLTVVFLLTTALYLVLLTFITLGILETLTNMQRAFYFLGFRLVFINHVINPLVYGCLDPQFTKVLNDVKKCCRRKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVA8</accession>
    <name>A0ABY7FVA8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_038498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="91" mass="9528" checksum="E346DE9A2AF4C045" modified="2025-10-08" version="1">MLKVGEGGGGEEGRRGGGGEEGRRGGVSATFPSPVSHMRMYVSHDPVTSESPCDAIDHTHPCIIPATGRCTVPHRLQLLYPGLSCSSQDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVH1</accession>
    <name>A0ABY7FVH1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="69" mass="7375" checksum="7094D8376EFD592B" modified="2025-10-08" version="1">MAEYRCVMPEFDGEANDGDHKNDAAEGAAGDDESIEVGGGCRSLVGVGRQRFHPHRPKVILSVPHCALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWI3</accession>
    <name>A0ABY7FWI3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="212" mass="25294" checksum="D9B23588499C50A9" modified="2025-10-08" version="1">MSLSTMFYTSLFTMFKTALFTMFNTSLFTSSIRHYSLGSIRLYSLGLILHYLLCLIRHYSLGSIRHYLLCLIRHYSLGSIRHYSLCSIRLYSLNFKRHYPLGLIRHYSLSFILHYSLGSIRHYLLCLIRHYSQGFILHYSLCSIRLYSLNFKRNYPLGLIRHYSLSFILHYSLCSIRHYLLGLIRHYPLGLIRHYSLSRICHYSLVLYVTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXL6</accession>
    <name>A0ABY7FXL6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3">1.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Dihydrolipoamide dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_011603</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR25899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="119" mass="12712" checksum="F08DC04910E8B6F4" modified="2025-10-08" version="1" fragment="single">MKTVCVEKNPTLGGTCLNVGCIPSKALLNNSHFYHLAVGKDLNNRGIEFEGVKLNLDKMMAQKDKAVKGLTGGIAHLFKQNKVTHVSGHGKITGANEVTVLKEDGSNEIVTAKNILIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYH5</accession>
    <name>A0ABY7FYH5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">KCNAW-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_011673</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003974">
        <property type="entry name" value="K_chnl_volt-dep_Kv3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01498">
        <property type="entry name" value="SHAWCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="13">
        <location>
            <begin position="28"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR25969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="459" mass="52742" checksum="434E2C989CD78E6A" modified="2025-10-08" version="1">MNRKVHADNSTIVWKIRPSISSKVSNQSVVILDIGGTIFKCYRETLCTFPESKLARLTEDDLELETGTDRSEYFFDRNPVFFNIILDAYRKGFVHLPKDICGLDFKKELDFWEISPGHVAPCCWEAYYRGQSEEDTMTRLMDNYKNNTNVCLMLGQRESFKERLWLFLDEPHSSRHAFIWAVFMSCIVVLSTVLLCIATLPVSFDKSSEEEVQVVQRIAVIFGFKNQTGKQFEELKWNDALLISMAAFTLVLTAEILVCFTSCPIKRRFWNTRRVLTFLGYICFWIIFSLEFNLDSLTTKPALVLFVIVRYGIILQLFRLFDFARAIKSFNIMALTVRSSKEELIMVLFLTAILVCLFGFFMFAAEYSFNEKMNNAFSAMYWALITMTTVGYGDYVPVTILGHVVACACAVCGVIILALPIGVISSKFYTFYNYHKYAEKHVTEYGNHIKAKVCPCGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYL7</accession>
    <name>A0ABY7FYL7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_013002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF116">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C1q" evidence="4">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="4">
        <location>
            <begin position="127"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR27298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="216" mass="24496" checksum="9C00AB75013952CF" modified="2025-10-08" version="1">MYFYNYIITTNIRSIQQIVFDRVVTNAGGAHNVHLGSFVAPVTVIYVFSTTLLSYPGYTKHFQFAKNNDFASRMFLHTSQIRNADPGEEIHDSNFYIFADFLMSRGVSPKIALNENAIIYSGELRTIQQIVFDRVVTNAGGAHNVHLGSFVAPVTVIYVFSTTLLSYPGYTKHFQFAKNNDFASRMFLHTSQIRNADPGEEIHDSNFYIFADFLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G152</accession>
    <name>A0ABY7G152_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46104:SF1">
        <property type="entry name" value="GENE 9195-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46104">
        <property type="entry name" value="GENE 9195-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="203" mass="21555" checksum="998C04EF99FF6936" modified="2025-10-08" version="1" fragment="single">AQTSIGGICQLGKYCPEGAISPLPCPQGSYNITVHRDYNSCLSQYLVLSTTGVQTGIGGICQQGHYCPEGTVNPLPCPQGNYNNMTGQGDCNPCPAGYYCTEGDSLWGYSLCLEGFYCPEGTGRNRSWCPEGTFSIVLGLDDISNCQQFLGGKHCNVTNLIAPVADCEAGYFCTLGVNTSQHDGILNTGTASVHRVHVVPQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1Y5</accession>
    <name>A0ABY7G1Y5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_014169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="136"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="311" mass="35256" checksum="59B4EE0DB368608B" modified="2025-10-08" version="1">MAEYKCHHVAAVLLFGYKRASKTDIKCSWLKHPKSAPPKTTVTMTDLYPPRQQEYRSFLYNCLGQLGRFTALHWILLEEPKPPQLPLPLIEDVLVSEGYLSSEDPRTYFRLSLVLSREKITQIAFMTTGQRENSLWAATRKLRFTASNFGQIIAASKRNRLCASLKKRLLSAYNLQKRAPIQWGITHEKNGLDAYCRTGGVTLVQTGIWLHESGILGASPDEFVQGDYCGRVHLQEKEQPAMSPDIIEVKCPFSAKDMTITQACHSNKDFYIVSTYYTLSPAKFSQVCSFPVECCFVLETETNKPTDVKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G311</accession>
    <name>A0ABY7G311_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31513">
        <property type="entry name" value="EPHRIN TYPE-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31513:SF2">
        <property type="entry name" value="MRAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2861"/>
            <end position="2880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2933"/>
            <end position="2953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="2867"/>
            <end position="2877"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="4396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="4396" mass="466159" checksum="78DF64BA1318FEC0" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3N5</accession>
    <name>A0ABY7G3N5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9454" checksum="5B0CCED0F355407B" modified="2025-10-08" version="1" fragment="single">SDLRREGIIWWTPSKNDDGKKKDKCEICCVNKPEKTFVKLQHEISCPSKIKMCVGCLWNWQYNPVKCHSCDQEKIRSPVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4C6</accession>
    <name>A0ABY7G4C6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045465695" evidence="1">
        <location>
            <begin position="25"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="486" mass="55641" checksum="65E0B532E507D067" modified="2025-10-08" version="1" fragment="single">MATKYIRRLSTALHIVLFIRYLQTLPTERKEAMKTRILQNSLDENDHVEFEKFLLDGRLRNGTFSLHYDMMSHCDICNSLCRETGRRDWIHTLLFSTPVEGSKVNLALDTQREMGHKHALKAFRSRSTMPSIVPRMSLLDTMNEKGHTTKTVQKTQAELLGVKSSDTDIRYVKRIVSLILRQGGISLTEDTNVYIVYDARKVVLPDSILDMKTEEIGAYLIKRHLASYGLFGCSKSDKPHIESVHGPKELLQKVKASKGVTIKRTAIKRPDTNKTLREKKEENRVKDITREMKKNDCLSSFESKDLIHLNKKAFPKDLTQSASVATIEFAGVKFKTSSTSGTQYLKYVENAVLMKTKISFPKIRNIVVCEEKYKFTPDVFKSATREQRQTKPDFSITHLKTGEDILSTHKFAKKTITTSAEGKQLINAVVLHMFAVSSHWPRDEEQLFTKKVYVVLKKPGNVYHIYNITEILSFIEMTKLALVLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4M8</accession>
    <name>A0ABY7G4M8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DMBT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_002966</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046447794" evidence="4">
        <location>
            <begin position="21"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="5">
        <location>
            <begin position="324"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR29398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="438" mass="50357" checksum="5561D81E7DCF7E5A" modified="2025-10-08" version="1">MRPTLLYLIVYLTVIRPIHGSRLDRLEDDVKSLKSFIFRELSSIRDEVKEISNRVDILENTTVTHDQSSQNQDMDITSNNLVDKTGESGKILERAGNKEGSHVVIADVQNMRKAYANDKKDLHQLKQDVKGHLRELEQKITSHMHNLTADVKHNIEYIHENISLANVTLSEFINESISNFSMFSDTIEKEIKQLIENTSQQLILQFNETESKIKQNISSAYRQNEDNLKRFWTLADRNVSQMRLKVDNIFNLIRFNFSEMPIQITNLSLELQTTKNEIKGVEERFGDKLKSTSSKLQKDIDLLLPCIHKEITQQGYYYPCAKDIRLANASSYGSTGVQGRLEVRHDNAWGTVCDDSFQEFFVDESYITNNVNVVCRMFGFRKCEYVVEADLGQGSGDILMDGIVKCGGAESSFLHCPYQRWINTSCKHGEDVGFRMWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4P1</accession>
    <name>A0ABY7G4P1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_014048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="193" mass="21161" checksum="8E0260A27CDE4E70" modified="2025-10-08" version="1">MENDGYTSASVTSSRQTVAENREEWTCRRACLVIAVSAVIGCLLSWTVLIPVFYMSRSSASAEPILNSSGSEQTVGSRVLPSPNESCVVAPEAGLYRVYSQITFAFDGRTHRSEVAHSVLVRTGDDEYMVQKKLISVPFRDPKLSKRHQTMDPSNLITSAKVATDDRICILVSPVGLVYKSQVDNVLMVVKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7Y3</accession>
    <name>A0ABY7G7Y3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">OZF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_002871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR29303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="243" mass="27628" checksum="B11A6D0653C55021" modified="2025-10-08" version="1" fragment="single">IHMDSYTTEKTITLEVCGVDLSRKSEIKHHPIRHTVEETYTCGICNAVFSQKSNLLTHMVTHTIQKPYKCEICDATFAQKGNLKAHKKIHTGEKPYKCEICDAAFTQKSGLQSHVRKHTGEKPYKCELCDAAFSQNREKPYKCELCDVAFSQKNGLQVHIRKHIGEKPYKCGICDAAFTQKSGLQSHIRKHTGEKPYKCEICDAAFSQKNGLHSHLRIHTGEKPYNVGYVMLTFLGKISYKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAK8</accession>
    <name>A0ABY7GAK8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RL5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_033992</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="8">
        <location>
            <begin position="29"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR31450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="90" mass="10665" checksum="A97E80AC1FB7AE48" modified="2025-10-08" version="1">MRKLQDEDEDAFKKQFSRFTKEGLTADNLEEMYKKGHASIRSNPEPKAKATKEVKVKRWNRAKMTKAQREDSVKQKKEAYMRKLKADDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GCD4</accession>
    <name>A0ABY7GCD4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DAXX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_033541</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.810">
        <property type="entry name" value="Daxx helical bundle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046378">
        <property type="entry name" value="DAXX_histone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046426">
        <property type="entry name" value="DAXX_histone-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038298">
        <property type="entry name" value="Daxx_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20920">
        <property type="entry name" value="DAXX_hist_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Daxx histone-binding" evidence="11">
        <location>
            <begin position="868"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="97"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="389"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="465"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="675"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="916"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="961"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="988"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1077"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1213"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1489"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1546"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="259"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="713"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="925"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="961"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="994"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1101"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1213"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1232"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1271"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1282"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1310"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1351"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1370"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1409"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1560"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR30999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1577" mass="178231" checksum="DCF3C961308C6192" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GDX3</accession>
    <name>A0ABY7GDX3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein quiver</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_033698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045818982" description="Protein quiver" evidence="3">
        <location>
            <begin position="25"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR31156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14582" checksum="67705BC5814F33D2" modified="2025-10-08" version="1">MTPRGGFVVAVWCILGLFCGRSESFRCYVCISDPNDEGCGDPFMTGTKEGDCVMCGKIKGKQSGIMVVTRTCLISAKLPANIAAECKSEGKGTPREHICYCNTDLCNASTRASMTTVLLFLLPTLVLSSRNYNCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D9G9</accession>
    <name>A0ABY7D9G9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CD109-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_006470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="4">
        <location>
            <begin position="534"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ93999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="641" mass="70970" checksum="7359652EA58E9DBB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DA82</accession>
    <name>A0ABY7DA82_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_006695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045622703" description="acid phosphatase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAQ94224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="305" mass="35123" checksum="2C20E76FCAA47D60" modified="2025-10-08" version="1">MKNKWCLFVVFYVSFHACLCAETLRLVNLVYRHGDRSPIEIFPKDVNQIEKWPQGLGWLSKIGMKQHYALGQLLKTRYIDSGFMKAEYSRYEISIESSDEDRCLMSAYSNLAGMYPPDDDQKFNHDIPWQPIPVHTRPAYEDNMFYQYLGNVSGWDHENISNIWRIADTLYCEKSHNLTVNTWADQKWNNTQTVFEKLRKLENFQFTLLYNGSEMSMLKGGCAFDCPFDQFVKLTKDAVPTDWKRQCGYPEPKGKSGSSGLSTGWIVSIGLTGLLVVVLVVGITCVVKEQRKHANMPYGRFDVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAY7</accession>
    <name>A0ABY7DAY7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF18">
        <property type="entry name" value="SHORT-CHAIN COLLAGEN C4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ93771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="186" mass="20615" checksum="38871A88F483E252" modified="2025-10-08" version="1" fragment="single">MELQIVLLATISLMKAKEETRFIDSSDFERLMLKLQIRTCGGEGHPALQRTSSSIKVYGAEYEFDFNHDGVSKLFGQNLNDEDAPCAVFKSPRATSVMIPKECFSGWTKEYKRANLLHWANNVKNFGIVKLAGDYQHASASEFICLDERPEMVVGGAVNINGKVFFLAEAVCGSLPCPHTFRGGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDP7</accession>
    <name>A0ABY7DDP7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_028447</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF240">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046172738" description="protein disulfide-isomerase" evidence="11">
        <location>
            <begin position="24"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="286"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAQ95757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="425" mass="47604" checksum="3BF62107B3B52F04" modified="2025-10-08" version="1">MKVLAIFLLVAVTDAPWCGHCKALTPEYEKAAKLLSEEGSEIKLAKVDATVQQKCATKYEVRGYPTIKFFRNGKPIDYNAGRTGADIANWLKKKTGPAAVTLGKVEEANKMIEKDDDSESDGAKVFTEVASSVDDLPFAIASEDALFKEFQMEVDGVMLYKKFDEGKNRFEGELTAENLKTFISGNQLPLVIEFTQDSAQKIFGGDVKTHILLFTDNVDADSENMLAYKETAAGFRGKVLFIYININDEDNGRILEFFGLKKEECPAVRLIRLEEDMTKFKPESDDLSAKYLKQFVSDVLDGTLKAHLMSEEVPEDWDAKAVKILVSKNFDEVAKNKDKDVLVEFYAPWCGHCKQLAPIWDQLGEKFQDNENIVVAKMDSTANELEDVKVQSFPTIKCFPKNGADDEDEEEEEEGEDGGDTHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DEU3</accession>
    <name>A0ABY7DEU3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_028474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ95784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="110" mass="12403" checksum="97F14C93BB07B89E" modified="2025-10-08" version="1" fragment="single">MACMEWFIKSDGTLSTSLQEVKQKGLNIERLTMNGDSTTFTRVKRSLFQDLKKSNDKNHILKSKHKLLSNNNSAHIQKCFSCGISQNKGNTHGIKTSLNALSAHMLTYCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DF01</accession>
    <name>A0ABY7DF01_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="481" mass="53370" checksum="FFDAA5F57703F661" modified="2025-10-08" version="1">MVSVCIISADDGRNITAKLKKSFSFCDVKEIPVGYADTVNVKEIRVFVLTPITVQRLISGGRSYINRLFQEPANALIYFCCDSSKTKEFGSLCEREVEGWKDVSKFSSSVSKDLLKLEYEVKSLCVDEEEHGHHHVNRFLLNPKNIVMSTNEEVHIVLLDEEKDGHRFGKVKVITDGGEIMARRIADNVWGFSPCDLPIGDLQLSVTCDGSHIGSDNLKVQSACAAGSEVLRAALTVRPVETLAELFDIHSKDLDDALARMEWSQIVSRILDIDLLALCTNYRLERFREKIRHKSTARPDNLVFDTPDYPSSPEASSWSSSQKRLSLDSGKGGSTGSEQYPNSSVNTSGASGKHRSHSGHFKRQPEVGYSTIDDRTGHRIVRANTDSMLGKQSPGSSRQKQRFSHLQQPQIPLTSSVRKHDYDEPWETECPLGAMVTEAKETGGLPGALQRNDSKRAGICLQKNSEGKPENSSVDHEGTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DG80</accession>
    <name>A0ABY7DG80_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BDH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_028978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF36">
        <property type="entry name" value="D-BETA-HYDROXYBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ96288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="283" mass="30954" checksum="AF8F2BBCCFDB8D0F" modified="2025-10-08" version="1">MKFKQWIAWHLFELGYLAVLAVLPFIAAIKSVATVLISGLLLIAFIAVIRKITRKLVDVDGQTVVISGCDTGFGHALTKRLDALGFTVIAGCLDDGGEGASKLRKWSDSGRIHVVKLDVRSDESVQSLVKYTKKHSEKGVWAVVNNAAVNFLGDVELCTMDQYKSIAEVNQFGVIRMTKAFLPLIRECKGRVINVTSAKGRISLPSNAVYGATKYAIEAFSDVLRLEMRKFGVRVIIVEPGDFGGTTGMLSPKSVIKLGINIASLEGNILHLVSPWQHCRLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHP8</accession>
    <name>A0ABY7DHP8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="79" mass="8838" checksum="D839E900B453FE2D" modified="2025-10-08" version="1">MLQELMLRIRQLETHVKVLQRASKEELHLHGNAEEKEVSSKMSSTSKPSSPEDHVVSLDERSNLLSGVGVKLMEEAGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIK6</accession>
    <name>A0ABY7DIK6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CCD57-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_029824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042481">
        <property type="entry name" value="CCDC57"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46725">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46725:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="776"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="914"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="985"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="353"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="528"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="629"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="798"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="994"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1076" mass="124482" checksum="FF63E99C579A57CE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIN0</accession>
    <name>A0ABY7DIN0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MD1L1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_029247</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008672">
        <property type="entry name" value="Mad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168:SF0">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05557">
        <property type="entry name" value="MAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75704">
        <property type="entry name" value="Mitotic arrest deficient-like 1, Mad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="528"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="341"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="485"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="602"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="723"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ96557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="891" mass="102964" checksum="9112DAC585C0F4EA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJG5</accession>
    <name>A0ABY7DJG5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_030028</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058981">
        <property type="entry name" value="MGRN1/RNF157-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF0">
        <property type="entry name" value="RE60872P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26192">
        <property type="entry name" value="RNF157-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="264"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="364"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="497"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="547"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAQ97338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="613" mass="67968" checksum="3FB8FF85B2EF6E3D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJX0</accession>
    <name>A0ABY7DJX0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PFD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_029680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd23164">
        <property type="entry name" value="Prefoldin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ96990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="129" mass="14585" checksum="998F60ED5C845D2C" modified="2025-10-08" version="1">MASSKATGQKSVDLELKKAFQELQGKMIMTQQQLKISDAQIETLKRTVTRNLLVEKELGRLPENTRVYEGVGRMFMLAPIPNVLNTLGMKNQAAESKIKTIEGNKTYLERNMKESEDSLRELVLSKTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMI9</accession>
    <name>A0ABY7DMI9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7042 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_022117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055470">
        <property type="entry name" value="DUF7042"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23069">
        <property type="entry name" value="DUF7042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7042" evidence="2">
        <location>
            <begin position="132"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="465" mass="51287" checksum="2E23F073192D2B5E" modified="2025-10-08" version="1">MATFLTFFKYYQHQGDWFERISAYGQCTFESPFSNSAWYDNTKGELTFTGTTMSGWSFTIFGGSTAIRSWRCVDHVTDTYLVLRTTSTFGVTVTGVTKSVYGYVCLALTRLSDASYIYYQQHDDVATAAVTCPDSLLHVADYTVTSSDGTLTCNGTDSWDVCTDVTQMTFDYTTCTTEVMFSAGGVLTCVATVTSGGYDYITVYNQDTAITSSTNRFACISTSGRWSSVAPGNCTAFQTPTTLPLAADQTTFVGHLIYVDTYFHNATTTASTGVSTGTIVGIIIVIFIVVPFFIVATMATIALFVCARVFITLLLEYTDIADHIPVTTRPPSPPGLYLKTTYLTLTEPVKGNEFPSYKEKGVLSLKDPRYKWPERKLGNTFATVEKEKERTLKLYGKKGMVGKYFKEKTKMLSLTEPERIELPDVATTPASLSNNQLKNGSTIKPLPPIHKNENKVIITNSSPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRC5</accession>
    <name>A0ABY7DRC5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FRDA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_024610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0410">Iron transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR00238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="309" mass="34301" checksum="B2403C17FA726D34" modified="2025-10-08" version="1" fragment="single">YVHGEIVGAFVLPHGGIALDPRNFNTTNKTEIQQANKLHEACLKVGHDIRSFGDVDDCLQKPCQYNLTINLDSNIAERFFAAQGYSNNVSLLSAFGPEGSNNSVPLRWGEVIPLLLVNMTATVKVVILSQPTRRYTETLDMTTELTNLGRHLGMFLHGLTERVAVVISADLAHTHKADGPYGYSNASEPFDKLMGDWASTMSSVFIDMAAQYVDRALSCGYTGLKMLDGMFTLGTPRLRPLLYANLHPSYYGMMAASFLPDVGPKRYDYVDGMWVYKHDGRVLHDLLTEEITEVMGKTVDFTICSYGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRD0</accession>
    <name>A0ABY7DRD0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_024036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF33">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="C1q" evidence="4">
        <location>
            <begin position="133"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="55"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ99663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="264" mass="30237" checksum="756CC9A0DB20915E" modified="2025-10-08" version="1">MKRILKETEGQFYSTKKTVKIMDRAKVAVLLCFLILHPASSLQDEPMFPTKFQYDEQLLEKVIRMELKFEEYEKKLDNAIELLNKSILDVNKSIVDGTDELKELESQIERKHEQIESTVNGKLQEFDHLADELRIPNVFFRAEYPTDLSNPNPIVFTKTVYDFGNGYDNVTGVFTVPVDGTYLFTMHLCSHAGKDIHYRLTIDDEDHLGGRNFNTGSHVCTSADVIAPLKTNSKVFVKSSQSSDVLYEDGSYRRNIFSGVLLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRP1</accession>
    <name>A0ABY7DRP1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="270" mass="30106" checksum="1AECD3D26311D922" modified="2025-10-08" version="1" fragment="single">EARRLWSQSPHFPHTHRPTSGYTYSHHRTSLSYTLDRGSGILDSPRPGNHTALFSGTKSSMNFPGLTKASIRNCLPCRCCKDMRKVPDCRVSDHGPLLAPSVSGGLIDVPMALWQDWNKSARQPLLRPPPPPGSRAFLDVSISLMSQWLYGRTGLVRKCPTAAFPTMAPSRPRAFLDVSISLMSQWLYGRTGLVSGGDDDDDDDDDDDDDDDDDDDDDDDELFFQFPLCYQEYKRSNSCVSDPHLSCSRAFPELSTALMSPRLYAGLDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUK1</accession>
    <name>A0ABY7DUK1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_024725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimers with GPN1 or GPN3. Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR00353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="245" mass="27777" checksum="DB32F13401F58073" modified="2025-10-08" version="1">MLHAALYSATVAVVNLDPANDMMKYKPDIDITDLITISDVMDTLKLGPNGGLVYCMEYLEQNMSWLEEELARVKGRYLLIDCPGQVELYTHNTAVHNIVQRLIKMDIRLVAVHLVDSHYCSDASKFISVLLTSLTTMLQMELPHVNVLSKCDLIQKYGKLAFNLDFYTEVLDLSYILDQFKDKEIMLRVMKAVDKANGYVFGDLEERNLQEMLSCAAGAEFEYEKIQNIQEHFVDDSAGTSTENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DV61</accession>
    <name>A0ABY7DV61_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondria-eating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_023198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031981">
        <property type="entry name" value="MIEAP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16026">
        <property type="entry name" value="MIEAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondria-eating protein C-terminal" evidence="2">
        <location>
            <begin position="176"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ98825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="264" mass="30643" checksum="12284E9C9EFB5F5C" modified="2025-10-08" version="1">MFNNSKQCQEELLEELEDKLKVWQEKINVLKRNIKKSNTIKKELLIELKAALEYLRQMNTFQFCERKAQLILQKREDAVNLLFEEYRNSAILERALLVIASYGSLIFIQKCLVLTSGEDMQLQKRWEPKRRNFLDSKTFTDDTPQQADPVHVDKQMKQLRKEVAGSILPIVQKAYMDASWQMECLSSLKPFINKCLFIGWMMVVQTPPMDFKSAKKGDHFDKNIFNQYTKSGKFIDFVVWPALLLNKDGPVVGKGTAQPGIITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXC6</accession>
    <name>A0ABY7DXC6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UBA6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_025333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF186">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="5">
        <location>
            <begin position="821"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR00961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="946" mass="104473" checksum="0B866322CD25CFFF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXI3</accession>
    <name>A0ABY7DXI3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PPD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_008986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd03371">
        <property type="entry name" value="TPP_PpyrDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017684">
        <property type="entry name" value="Phosphono-pyrv_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051818">
        <property type="entry name" value="TPP_dependent_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03297">
        <property type="entry name" value="Ppyr-DeCO2ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42818:SF1">
        <property type="entry name" value="SULFOPYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42818">
        <property type="entry name" value="SULFOPYRUVATE DECARBOXYLASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="5">
        <location>
            <begin position="49"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="4">
        <location>
            <begin position="249"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR02428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="421" mass="46520" checksum="A7C9085814A2DA3C" modified="2025-10-08" version="1" fragment="single">HKDHAFRYKIKGVENSLGYFQQYEDQRRRNAEAGELTELVRDFLDPATFYRQLKSKDIDFFCGVPDSLLKDFCAYVTNNTPVENHVITANEGNALGLAAGYHMATGRSALVYLQNSGLGNTVNPLMSLALPSVYSIPMLMLIGWRGEPGKRDEPQHITQGQATPGLLAALGVPFQPLPDYEEGAELALQSACHHMETVKGPYALLVRRQTFSPYKLPKKPQEYPLTREEALKLVINGLGHKDVVVSTTGMLSRELYEYRMAREDGHERDFLTVGSMGHASSIALGIALQKHNRQIYCIDGDGSVIMHMGTMATIGQRGPENLKHIIINNGAHDSVGGQPTDASNSEGFDFGTIARGCGYKETLLAVTEEEVAAAVTRLRLTKGPLLLEIKIRLGARKDLGRPKTKPIENKKDFMHFLALSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXS6</accession>
    <name>A0ABY7DXS6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTGR3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF3">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="21"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="279" mass="30472" checksum="C83B587348C200CC" modified="2025-10-08" version="1">MASKHIPSTVRKIVALRSSHKFREVAKIVTEPTPKPGEGEILVKNRFVGINASDINFTAGRYDPKAKFPLDTGFEALGEVVAAGPKSLYQPGQAVMYCQYGAFSDYKVVNSNRVIPLPAVKAEFLPFILSGNTAAISLDRVQWAKLKGCHVIGTCSSDEKVQFLKKGVDVVYEAVGGEMFDTCVDSLALKGRLIIIGYIEGYESDKGYKPSRVLATLPARVQYFNEGRMQSIVDKGERTPGGPFKGLEKVADAVEYLYSKKSIGKIVVELGEDTPRSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZT0</accession>
    <name>A0ABY7DZT0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CO6A4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_009072</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047469981" evidence="3">
        <location>
            <begin position="21"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="69"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="257"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR02514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="332" mass="35876" checksum="BF391F40129D87A9" modified="2025-10-08" version="1">MYWNVPFVLILSSLLGMCRSANIDECAMNTPCKNAATCHNIIADFRCECVPGNNDKSCSTVCNSDKKADIVFLIDGSGSMTLIGFEETKSHIEKFISLFDIGPSKTQVGVIVFGSSAVIQFNLNKYNSADGVKHGLQDIEYPNDNTDVTAEALRLAKSSMFTPGGGSRTGAENVVILLTDGYSRTSDDNLVAAGELKAAGITIYTAGLDGPNREEMESIASGKEYYFSVKDNDGLDNLRDLLAVTTCTICNSDKKADIVFLIDGSGSMTLKGFEETKSFIEKFISLFNIGPSKTQVGVMVFGSSAVIQFNLNKYNSADGVKNGLRDIEYVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E102</accession>
    <name>A0ABY7E102_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SRR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR03480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="82" mass="9298" checksum="6CC14AC2BF23FB42" modified="2025-10-08" version="1">MYTDVCFLFQTDDEIMKGMRFAFERMKLVVEAASGAGIAAAMSERLRQMDAALRHVGVILCGGNTDIDRLPCYLILIRQLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1M5</accession>
    <name>A0ABY7E1M5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_009418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01167">
        <property type="entry name" value="LPXTG_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR02860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="289" mass="31118" checksum="EAB2AF14C25DF440" modified="2025-10-08" version="1" fragment="single">LQVVGNTDLYFDAFLLDKSPVVNNRIVPPPPEQHGLEPAYDFIKGNVENNWRISLNSTTSKDPVIIESRGIIRINYMAEFTTTPVTTKMTTTEATPPLPPAPSTVKPGAPTKERTPYAKPTWPHKPTSPTTCPPCTPLTCPTPTPVVCPSTSTPFVCPTTKCPPTTKCPSCTRCPTSVITQPVVHCNTSSNCPQVTCPTPIKCTTFRCPSTSANNPRITQNKCPTVTPCATATTVASGQTGSGAAGLAFGMLVIGLLIGVFGLLVYRRKRNVTPDRRNILDKYLDNADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2N6</accession>
    <name>A0ABY7E2N6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apextrin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_009626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031569">
        <property type="entry name" value="ApeC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324:SF33">
        <property type="entry name" value="MUCIN-5AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324">
        <property type="entry name" value="PERFORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16977">
        <property type="entry name" value="ApeC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045936841" description="Apextrin C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Apextrin C-terminal" evidence="2">
        <location>
            <begin position="346"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Apextrin C-terminal" evidence="2">
        <location>
            <begin position="467"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR03068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="535" mass="59497" checksum="ECA30277D65343D1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5Y1</accession>
    <name>A0ABY7E5Y1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MTAP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_020791</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027324">
        <property type="entry name" value="MAP2/MAP4/Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001084">
        <property type="entry name" value="MAP_tubulin-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501:SF18">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00418">
        <property type="entry name" value="Tubulin-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR05422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="420" mass="47495" checksum="8B0D6EA29D1DE9D2" modified="2025-10-08" version="1">MSSQMGQFTHRSRESGRLSPVLDETSIDMSDQPSQQHRFNEPLKIRKGRNFVDFKPPSPTVVHVPNRSFAHGRWTNVTVQRKNGRYVVIEQRPVYTQFTDSSTVKRGYQKDLFGPDKSWTKKKAPWSWSTKGSYIGRSVNRGFQEPYLPPMKERYSHVASRVGSMDYADHVPGGGTHKVPSFKLKWEAEAKIGSLPPPTTRSEGAPGLKLPSISPRYGASADSESFTTIHYTPGGNVVLRKQRYLDAKSQVGSLDNVSYSPGGGDISIPQKSIKWKKESKIGSLDNITHLPKSSNVQIFSDKLKWKTEPKVGSLDNAHHIPRTKKFKVPNFKQDWGKAVASRVDSLSNVEHTPRGGNVQIIDVPKKWKGKSKIDSKWKFNYDYKSLFGDDYDEVDRQTFSNASSYPYTVCMQQKTYVESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6D2</accession>
    <name>A0ABY7E6D2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_019875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046840873" evidence="2">
        <location>
            <begin position="16"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR04506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="205" mass="24062" checksum="5867FB4263EF1AF3" modified="2025-10-08" version="1">MKWILLCVFVAGAYATCEDQNVEACPYDPCLDLTCDVEGAQCQPDECEPCEVTWTADSADVTDQPLTKEQRKERRKNRKQTFVKRKLAKRIEKKKEWKQMSPEDKQAAIEEKREKLVQKLLAKGKEDKVERLRERWAGKTARIQERKDQLAAMTPEERTAFFEEKKAAKKARKTEKRKTFVKGKKDQLKARKQVKKQARQDKRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7I8</accession>
    <name>A0ABY7E7I8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="19" mass="2175" checksum="104FDB2B5CABC371" modified="2025-10-08" version="1" fragment="single">MQIILITYTTLLISHITSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7T5</accession>
    <name>A0ABY7E7T5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="195" mass="21417" checksum="8DD18A29FBBF305F" modified="2025-10-08" version="1">MAGFCAKPIVMPQEIACAYVARSLLSSIGTIGRSGVAHTDKEARENSDQENADNKDPNCENGTSEDEPLLEGHRLNDMSVDGDSSIDDLKPKREKDVWTDKPFRDIHNSLCVQKKGEETETGVHGQNTEGSSDETDVKRLDMQKGVNEQSTEEPSDETDVKRLDMQQGVNEQNTEKSSVETVVECSVKLSVEATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAE2</accession>
    <name>A0ABY7EAE2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_016968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="173" mass="19409" checksum="228FD12DBED9FC50" modified="2025-10-08" version="1" fragment="single">MSYFSMLTNYLGPSSCAAFLENGREWPVALDGQIALQRCRDGYQGDMYRRCQNGIYLNLVNNCTRRAIQDLHAQVLNGFLNTTEALSRLKQETTILTTANENLLTAGDLQNIIQILDKVIKDIEVNSATIVNDTDNGVGADSVINTIDRFISKVVNSSHENWNKTFDKPNMCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EC37</accession>
    <name>A0ABY7EC37_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="111" mass="12054" checksum="A15A7F5ED36AEBA2" modified="2025-10-08" version="1">MLSSNGLNISQLAQDVKERLSKDKSLDVKDSPKEVSDNENQSNVPVGANVLPPGKSDEEQGLIPDEFEYHDAMVNSSPLGSMAHDFTHNIESGEATHAHPSNDGEEQLRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EE99</accession>
    <name>A0ABY7EE99_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TSP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF21">
        <property type="entry name" value="SEMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="114" mass="12004" checksum="1E18ACC501603DBC" modified="2025-10-08" version="1" fragment="single">DGSWSAWGSWGQCDVTCDNGTISRVRACDNPAPAHGGDDCPGDKEQTTTCVMNHCPGMGWSTGSDWSICSVTCGTGLRQRSRSCQNPLASLMNNSCSGNAEETQMCSSLLCTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEQ6</accession>
    <name>A0ABY7EEQ6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="28099" checksum="055D7F9144B3479C" modified="2025-10-08" version="1">MVSEFARKGPCFASVCAAGRCSFKAGTCEWRNVQERDHFDWSVGDCSHFIDTNTDENKTGTINETHRPNPALTYCPLEYLSTITRVHGLKSNTYSPCRFPENRDLPRVSSKISYNPKLPGQFSSMVLMNQAARDDDTIIDEFLSVIHHDCVCLVGSGGLVRNQYVMVQTIFVLYSYFFFARKMNLWTNVLVSNCFICCSAQIFRIKPQNVYTVLRQNNGVVINFLFQNERKLFTSDEQTLLYTSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFI8</accession>
    <name>A0ABY7EFI8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052787">
        <property type="entry name" value="MAVS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21446">
        <property type="entry name" value="DUF3504 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21446:SF6">
        <property type="entry name" value="MITOCHONDRIAL ANTIVIRAL-SIGNALING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="845" mass="95642" checksum="8DA74D76B9709D59" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EG55</accession>
    <name>A0ABY7EG55_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="393" mass="43922" checksum="817338E0ABAA734E" modified="2025-10-08" version="1">MHRSCKTIYEGIFEQPDNIEHPGHVPSANLRSDSSPDFNNPCTKVKEEINDVGDHVLVEQLDTTPGELGTVHGDLHTHTFSSLAIRVKVEENDGNDNNGSTAQETALKPDIQVSVSPSDSCEDTVKSEQAPLALNDLLHENEPARVPGSRSLPSDSIDGNGKIQSNEVCSVASSKPTLPDSHSLTRSQISSVRSPDIGSSHWLKVAKFIKYAEQEILVSCPGKEVDFTNQEHLLEPVLVFERREDIDINGGYRYKLHAASVKMSDFLREHWTELSEEGIKRTMCPQVVNARGKDVSFLLVFIPVDRWHRPLFGENKVMVTPSKSPNGLVEFPSKEQLIEPLLIVERRQDKDMIGGYRRVILFGNNGKNYLKAEKREHFVHKLSMLEAEMVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHX0</accession>
    <name>A0ABY7EHX0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CETN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_018445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR08487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="347" mass="39219" checksum="827C86DE0D4F5F46" modified="2025-10-08" version="1">MSGKRSGKKGKSRVSFAEAEEKPPTQLELMKAELERLRRRDEEKQKRQEEYKKEEIRRVRAQMDAEKEAAGLQLIPGSRLSREEIKKKLNMEEKCLLKEEQTQIAGETAQMKATVGMKHGLHHGKRKPPDLVALAAAFATPTKSSSVHGLPDRVVRQMTMEEIMDLKKLFDLYDVAGVGYVRRKDVHKIASILGFRMTKAEFKTSIDTVIADPTAKVTFVAFLDFIINASLSFIFRYRNSRPDGQDTVIADPTAKVTFVAFLDFIIKEQEGNDPFEEVQQCFRILDHDDKGYVTMNDLRAAADETKCALSNRQLAEMVSEADASGDGQVSLDEFTIIMLRTSAFNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJ18</accession>
    <name>A0ABY7EJ18_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="145" mass="16327" checksum="58754F8558A8239A" modified="2025-10-08" version="1">MTSKFYILKEKLTDLWQPRSMTICVGHGTNKNEDGVDIKCLVLHSSKETDLSTLSALDKESLGHDFTSTNVGSFSRHTTFFYSTEGRHCDAHDEVPLEEWNLHDDEEMKDESEGLAMWKIIAISVGGTLGFALIVAVMCYCKFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EK58</accession>
    <name>A0ABY7EK58_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRAM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053359">
        <property type="entry name" value="CRAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35577">
        <property type="entry name" value="CYSTEINE-RICH, ACIDIC INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35577:SF2">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="895"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="895"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1148" mass="120878" checksum="6D55C24D2B7B7C92" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKW7</accession>
    <name>A0ABY7EKW7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="43037" checksum="D4872DE91C66F6BD" modified="2025-10-08" version="1">MASLPIQCEMCLEENAIRSCDTCGPVGEVCLRFHQKGRSFRTHNINVLNKESHGAVRIDITEERCKKHPTKIAFFLCTIHDSMVCGRCLHSEHSPCAKEVVDLEQEGAKIDCEKVNTMKSLFNELKDEISLMKDEAAQSMGSYKNNADKCVEECMELGNKIKQRVDHLTSSIKDGIAMKHAENVRTHSRITDTCDEKSKWCANEENKIDDFVDNNMAGYLYLMGRHFEKDISNARSDVKEIKSKHIFKGIDFKENKTILKCLFEDLEDVCEQHEEVTGSDDGNTDDVATSTPEINKTRRVLTALLNQAKHNLDQSEKERAEVQAMCPQIKEYFNWTQPTGTVEVKDKPFTYNFDDEEYIILLVFAFPDGIQTVIIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENW2</accession>
    <name>A0ABY7ENW2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="127" mass="15207" checksum="9891C01F5F91E5E5" modified="2025-10-08" version="1">MSPLRPSENAKITEFWMYTRFTFHERYTYTTSTESKILKSKEAFPCRMLFYAGRHSKATWLDCLYEQTTHTQFLILRSPEAFHGRMLFQNVRHSTDMQIDDRLEEYKQTSQTKSLMWRSHGALPGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQ84</accession>
    <name>A0ABY7EQ84_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ANR12-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_026283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053210">
        <property type="entry name" value="ANKRD12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149:SF14">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047430427" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="632"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="782"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="818"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="844"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="862"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="880"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR12103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1129" mass="125128" checksum="A3DFD4941AB4E341" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ES33</accession>
    <name>A0ABY7ES33_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_026980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="71"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="3">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR12800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="464" mass="51800" checksum="B9289B5475D6DAE8" modified="2025-10-08" version="1" fragment="single">MRRLRLAEAELEEQNDIFTSGYIDINTHTPSPDANLYTHTYNDFDTETLHFHQTSACSLSEAEFELSCQKLTDCQRNALHVVKKHFSEQSHVPLRMFVTGDAGVGKSFLLKLIVAFLQLNTPVTCAVSPVKCCSPTGTAARLINGQTIHSLLRIPVDKYLNYAGLTSFQLRSLQNQFVGVNTIIIDEVSMVSDRMFTFISRRLCEITGNSSPFGGLNIILFGDFFQIKSVCGSFVFHNKVLWELFFPVFLRQNVRQSQDIQYINLLNRARVGMLNRDDIVLLKSRLDIALSHPSSLCIFPTRSSVREHNQQVTAEHYFSTDDSNAGEPCDSVYIPEDDRDAGNLPHHLDISNQSGVMLLRNLDISRGLVNGATGIVKNILLDSLGHVQQISVIFDEPANNMVAIETMEHKFVYAGRSIVRKSFPLSLCWACTIHKVQGLSTSSCSLDLGSSVFQPGVAYVALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETZ4</accession>
    <name>A0ABY7ETZ4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="1">
        <location>
            <begin position="99"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="275" mass="31222" checksum="D431E6D34BACD707" modified="2025-10-08" version="1">MFRPIKVSYEYVPTTTNDTIFIVKKMKPERDPFLCTCGPCKKFWRDTFSDSGDLLRESSQCRAHHTAILSAESKVVKIGDRILVQSRFPGTVKWVGVLDEDSIAPELYVGVRLDDNVNSTHNGVYNGKRYFHVPRGHGAMVKYMENIYSQAGMQGPQFVEPYASPPKTAATSVRASPVKSLREPIIHIGDPNDIALRDMQRLSQMDTKRKVRKEDKDKKEMERFKQHFGGVPEADRLALTLKKLKLAYQEGKTLMQRKTVKDYDAGSDSGISDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUL8</accession>
    <name>A0ABY7EUL8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="94" mass="10943" checksum="D6278961E687DED8" modified="2025-10-08" version="1">MKFNENWNVKLHYDENGKERRLTLKFELDIVHANMAKMWLTTKNLNKRFSSLDYESHELMIHTDVEEFLVGDETDVGTLKNGSGIDINIVRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUM6</accession>
    <name>A0ABY7EUM6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Regulator of microtubule dynamics protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein FAM82B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_026274</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049039">
        <property type="entry name" value="RMD1-3_a_helical_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF16">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21033">
        <property type="entry name" value="RMD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR12094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="245" mass="28373" checksum="3EFC0105683158B7" modified="2025-10-08" version="1">MATNRLGFFFEKQFQRLYQLRNGCQSWRQALKHGRPSAVRRICQPLAVTAPTLSLFGISWGGSKPKEGAPEPVKGETVQDQKTILLERADRLYSEHNIDELYDLLIEHKWYAILLDYTGEFEGKKQRIKNAFQVKEHLWCFTMADLKWYERTVASALFATPPSSTYDEALQYFLKAEEAEPNFYSMNLLMLGKTYLKLQDGKMAYQYLSRCRDYPMNTPDDRRANAEAKQLLAMLTSGAGRKTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EV22</accession>
    <name>A0ABY7EV22_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_036127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="62"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="124"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR11051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="326" mass="37327" checksum="A00C41FBACD95887" modified="2025-10-08" version="1">MANIHVQCEMCCEEKAVGCCNICGNICESCCVIHKKGRAFQNHILKMYGKDGYNSRSIIYDITEEKCKHHPNERALLFCQIHELMICGRCFRSDHISCGHEVVDLCEEAGHVDYDQFNAMSVALNAIKDDSKRIKEEIDRQKERSNTHAVKCKKELDDLENRLKRKVEHSISSFKEEAQKYHDENIAAFSCISSVCEDKVSWAIKEESQLNEFVNNSLTGRLYLMSRNFDKGISEVKRQMKEAEYKNTFKNVCLKENTAALKCLIEDLTDVCELQEEVDGSDEVTTLSIGNATVENEKTRKELFEELIQAKLDTDKAETVIILVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EW44</accession>
    <name>A0ABY7EW44_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="106" mass="11933" checksum="7154D7CBF8DC2B2A" modified="2025-10-08" version="1">MAKDPVIQAIKVTFQHSKLGLSKDFDQESFSTVDGNEQPKDDRPDDSVDETEIIESVKSLKADKAIGWPMKPIHFINGMDYGATFGRMKSKASYFLNVSRDSYQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EW80</accession>
    <name>A0ABY7EW80_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ESRP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_027389</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ESRP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="334"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="681"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR13209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="759" mass="84334" checksum="C4549A0B06E5F154" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWH0</accession>
    <name>A0ABY7EWH0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="145" mass="15831" checksum="C3BE5EAE649285D4" modified="2025-10-08" version="1">MALAAYSPRTPRLQHGAGDHRLLMYRFSKHRSKSCGAVTRATRVRGPSDTVGNEERAAGISSRDTKGYTQQRSTGRRAVFGDSVLVVTNAGEERRAEVRGHVTTGGDRKSTDIELDVARNGVELSWRNMVGPQANSGFARLDMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXH9</accession>
    <name>A0ABY7EXH9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF9">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="241" mass="27141" checksum="4CFA5ABD1388AB0C" modified="2025-10-08" version="1">MAKPMLLLIKVEHILNCITFTREENMVTVSPKRNAIIKTAAKLIMNDIRSTEYDKTEYPSSAHIMSVEGNRKIVPDSLQVFLKQLIDNKNSKWLITSLGQAIAALPRSVICPLKLGLGVQLYHQYGSRFLIEALNSLGFCSSYHDFQRFETSAVISQEHIIHRQDDQFVQFIGDNVDHNTETLDGHNTFHGIGIVATETLKDDKVCLVPGIRATSDDLINIGKLNIHFYKQSSNGTKTTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXX0</accession>
    <name>A0ABY7EXX0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RPB4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_004900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="5">
        <location>
            <begin position="23"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR14795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="141" mass="16332" checksum="DCED8D89388A5C68" modified="2025-10-08" version="1">MATGTSTTADKQEEDASELQFPKEFENAETLLVSEVQMLLEHRKTQNESAEEEQELSEVFMKTLQYTQRFSKFKNRETIAAVRNLLMSKKLHKFELAALANLCPDNAEEAKSLIPSLEGRFEDEELQQILEDIHTKRSFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EY22</accession>
    <name>A0ABY7EY22_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAGPA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="entry name" value="Serralysin-like metalloprotease, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40446">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40446:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="Adhesin YadA, collagen-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphodiester glycosidase" evidence="2">
        <location>
            <begin position="361"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="699" mass="74968" checksum="1CEBB2AA20A4F0E9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZ25</accession>
    <name>A0ABY7EZ25_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_026581</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046487154" description="peptidylprolyl isomerase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="27"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="81"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="215"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR12401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="391" mass="42610" checksum="57B68D54FB76CBA3" modified="2025-10-08" version="1">MFSPLVIAVLVFFQAVESVKVTEFVYFDVKHGSKDLGRIEIGLFGDVAPLTVANFKQLATHELGFGYKGSIFHRVEILPIEMALVLKHDGAGILSMANAGPDTNGSQFFITTVPTPWLDGHHVVFGKVISGMDVVHKIEKVDHTVLDKPTVDVVIQDSGVLTKDAYDMALEKLGKMELIQTSVYFGSMVLMIQSLYVINLTEAKDTLVTDVVSFDIKIDGVDTGTIDIGLFRKTAPRTVDNFVKLAEGNTKDGLGYTGSPFHRIIDDFVVQGGDVVFHNGTGETSIYGGRFADEAFTLNHYGAGWVSMANAGPDTNTCQFFITAKAANWLDGKHVVFGKVVRGMWVLKQILAVDTDKATDRPLVDVIIAKSSAKKVDEPFTVAKVSADWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZQ5</accession>
    <name>A0ABY7EZQ5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCNL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_004942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd20589">
        <property type="entry name" value="CYCLIN_CCNL1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="58"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR14837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="282" mass="31478" checksum="A76CAF810DBF996B" modified="2025-10-08" version="1">MAEVTEQKPGATMERDFSTIILTLENVLIPDEKLSPTPSLLDGLDLDTETDLRILGCELIQTAGILLKLPQVAMATGQVLFQRFYYSKSFVKHNMEVLAMACINLASKIEECPRRIRDVINTFHHVKQIRNKKNIHPLVLDQNYINLKNQVIKAERRVLKELGFCVHVKHPHKVIVMFLQVLDANQNQKLVQCACKIVVKSEIVILGGGSQCALKATINSTALDQSPAFHRLSARRPVDALAKISRNVDGGKENVQTGKSSLIDGTIFVRWTTCEIEGITEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F020</accession>
    <name>A0ABY7F020_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_005637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF63">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR15532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="337" mass="37314" checksum="F5F4EB8F7F36B60C" modified="2025-10-08" version="1">MVLHSSQVMDLLDSSRGMDLLPDNIRAMDPLPDNSQAMVSPHTASSHMVSQVMALPDRDMELLPSHMDNLDILNQVCRCRVSKLVSQLPSSGCSVLRVFLGVPQGWSTSDLFNWECIEGWSHLDETVQTGVADWGPIAAYFMITPSLCSLFKMFSSLHFMSVSNIKSCPKSLICVQDSAVDHNEVVRVTREFKCCAGCPWCACTEGLAHEVVVESPPGTVVGYVLQQQSCIEPKYAIMNASREEILTIKGPMCVISGPCCPDVEFIIHSKDGTTEVGKISKQWSGAVREYFTDADNFGVSFPMDLDVKMKATMIGAVFLIDFMYFEQSGNQNRNNHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1Q6</accession>
    <name>A0ABY7F1Q6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="23" mass="2760" checksum="47364F7A5BD11FD7" modified="2025-10-08" version="1">MTICWTLLSNRKRKVLLLKLPMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2C6</accession>
    <name>A0ABY7F2C6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G3P-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_005327</name>
        <name evidence="9" type="ORF">MAR_005335</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="7">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR15222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR15230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="278" mass="29668" checksum="04D80DAE007D21A3" modified="2025-10-08" version="1">MSIKVGINGFGRIGRLTARAALEQSADQVTVVAINDPFISLEYMGTVEAKDGKLVINGKAISVPFHGPKMELTMSWNLLVSSPPLTKLVNASCTTNCLAPLAKVINDEFGIVEGLMTTVHAYTATQKVVDGPSMKDWRGGRTAAQNIIPSSTGAAKAVGKVIPELNGKLTGMAFRVPVQDVSVVDLTVRIEKGASYDKIKAAIKAASEGKMKGILGYTEEAVVSSDFIGDNHSSIFDASAGISLNDNFVKLVSWYDNEYGYSNRVVDLIKHMAKVDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2L7</accession>
    <name>A0ABY7F2L7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_031022</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="46"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR16428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35452" checksum="0581523EA7C29A55" modified="2025-10-08" version="1">MFSVIQITAIVCLTVSLICALSTIISSFWSHPADGFYIEWTKGERLAVYMSICDLLLNISLLVNHLHILITKTHTRPKELCSFFGFIMTEFVLAQILMVNVVAINVFTTMFFNTNFSFAKSDRGILLWSFGVPFIGALIAALLEQFGPMEIVCFFDAVNGRVANLVLITIPITTIMVVNVLLYILTFIKIRIDVRAIRQNLGNMASTAGRHIRAARNMSMFVVAFFVQWSSLVLTGVWFLLADDVADIPEVLKHIVGIFTNLGGVLNLIVYLAIFRKTRPMLNMATGMEPPKSHKVSDNNKEPANGSEQGNEEFEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3Y0</accession>
    <name>A0ABY7F3Y0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="39151" checksum="E5B35E4C6BB1BB9B" modified="2025-10-08" version="1">MIKVNKKTRMKKNFRTLVNICLVVFVVSLIVGYTKWNMIPVNSSSSPSPITKYDLRILVIVYNRAQSMLRLLNSINEANFDGDNVKLEVWIDRSKAGVVDTLTVKTAEEFVFKHGHYEVLKHSQHVGIYGQWFATWKARVNSSEIAVILEDDLIVSPHFYKYLKLVHNKYDNVPEINGFSLQGISIKHAIGYSSQTLEAPESCLVYLYPVLGTWGFSPSRDNWIHFLEWFSQVIQNKTFQPYVPGNVVTAWYKIFQAQGRADGEQSIYHIYHSWKFKEYTLYPNFKGHKGLTTNWLEAGLHYSGNASKPSNELLKEWKSDYEHLPDQPKHLNLKGVVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F594</accession>
    <name>A0ABY7F594_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CPMD8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_031919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022041">
        <property type="entry name" value="Methyltransf_FA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36695">
        <property type="entry name" value="AGAP008648-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36695:SF12">
        <property type="entry name" value="AGAP008648-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12248">
        <property type="entry name" value="Methyltransf_FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Farnesoic acid O-methyl transferase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR17325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="221" mass="24793" checksum="A52724BF9E9E19CC" modified="2025-10-08" version="1">MEGVFVASAKQILFETKGKNDAHILLQNEPEKYLSDVYEVVLGLNSNTESHLRLLQQGTVLCSLKTPDILTAKEYRPFWITWNTTLAIGKGTRIDISSIILLTRLDFPINSMRISYGFGSSGYFRFHDKSDVVSTHQTTTSRRDALHDTRSSIVIALAISTGCLGFILLSATLGGCFLWNKRKSTVMGTHSQANPVSGEHYEELRRKEQDSEYQHYATLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8M9</accession>
    <name>A0ABY7F8M9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_000376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR18538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="193" mass="21339" checksum="E881C7A757E80DC4" modified="2025-10-08" version="1">MEIERTFSFYKEVQGVVFLLDYEIISINGPRFDYSRDVYFCYTLFREPKSPSGEKILLSVTNVTETPDLKLSYCTFVGSSGTDVCCYQTTVDGSEHGNIPVVSDLVIHCCYGGDDIHIFVTNELNEVCVTELVYLKCSTIYRGECELGGDCAIGSAPEKLLLSSIPCSFEYTVSGSLIVPDVSEVPETHSPCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAY9</accession>
    <name>A0ABY7FAY9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CALM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_001178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR19340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="198" mass="22387" checksum="295B20D21C65CD87" modified="2025-10-08" version="1">MASKMAYNLEFTKGVIITRAVTLDFNSDVLSDRIMVYCLKDTATPLTEQQIIDLKDAFAAFDKNNDGLLNFPEVKDMLVSIGRDPRSCRVNEVLKEVDTDGDGAINFAEFLNFIAREQLAEGPEEQSELQQMFAMFDRNRDGRITHAEMKRALAETGQNVPDSEIESMIREADDNCDGKVSYKEFVATMKKKYPGVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBW1</accession>
    <name>A0ABY7FBW1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF14">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="41855" checksum="590D3C23ACE0CFE5" modified="2025-10-08" version="1">MEQLIGPDIAGNPAWNLRTKVPRNIVTTVPWHQDVSYLDNDKYRMLIPTAWITFVDATEQNGCLECCWGDTFYTILEEDEMKNTLGVDLDRDKRALPVRSGGLILFNNMIPHRSLPNVSDGIRWSIDLRWQRATDPAGLWGLKNGVVMRKSSDPNFKVDWTEFDSVNRHIVQTEYIKGDKAVNVSYLDNDKYRMLIPTAWITFVDATEQNGCLECCWGDTFYTILEEDEMKNTLGVDLDRDKRALPVRSGGLILFNNMIPHRSLPNVSDGIRWSIDLRWQRATDPAGLWGLKNGVVMRKSSDPNFKVDWTEFDSVNRHIVQTEYIKGDKAGPWMKKWEIVHMNKHVDRFLEQEAASKGDKSVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCC0</accession>
    <name>A0ABY7FCC0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PZRN3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_000161</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF157">
        <property type="entry name" value="RECEPTOR-ASSOCIATED FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="55"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="203"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR18323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="364" mass="41187" checksum="FDFBCAFB409CED7B" modified="2025-10-08" version="1">MENLSEMNLSVDSRLTKRTTPGPLQTTYLDTADYTGTMGFGVQRFIGPVDPNLICGICSAVLEDAVLTPCGHSFCQSCITTWLARPGTDTCPECRSHVASRDVKPVLSLRNLINGFDVGCDFNERGCKVILKLDRLKNHLQTCGYVPVTCAGCEEAVSRFELASHQIRCEGIANSVRDEDDDITPQQRLGNIRFTHALTSIDVSELISKIASLEFQAKTLKRDLQIAESKNRVLDREYRKTKDELQHKRCELLELNNEFDPDYEYGYCPQSIAKLSLLIARHLLNKPSYIDRDKIFTSVRRCYDKYARCGSEFEHDVHMLVATAFASNWFPEPARSTFHHWLQSIARYRQLSTNAAKYAALVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCF8</accession>
    <name>A0ABY7FCF8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">STAR9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_001671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF8">
        <property type="entry name" value="KINESIN FAMILY MEMBER 16B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="3">
        <location>
            <begin position="756"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR19833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="909" mass="102479" checksum="6EF1DFE5E4E43FA5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDZ9</accession>
    <name>A0ABY7FDZ9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED17</name>
        <name evidence="8" type="ORF">MAR_000834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR18996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="343" mass="38075" checksum="D2C97AB17F19A72C" modified="2025-10-08" version="1">MSECLAKSAQKIDFGEEDEGIEGKQTSEEGTTEKEESAFQPSLWPWDNVRNKLKTSLTEIGVLLDVLNIAKEKKYMAIVQVQQDTSEPKSALQLLAKKKGLNTAASVLISGAERLKQSQEEKGGVSSHDKFHIELLKLRQNWRLKKVGNSIIAGSRFWQGGTFEVTKTTSLPSDQEGSTAQQYPLQVVIPSELEGSSYLQLEIKSVPDSMDLMSVTLQVPDGFGRTPLNAHWQSRLDRAQNVLFCKELFAQLAREAVQLKSNVPHVVVSNQIITNIFPGVQLSIVLCHSTGKGDKKTGPHSGKMDHKHVLEHSLHQLLREVHHRTLHLAAPHPVTAPFGMSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEH7</accession>
    <name>A0ABY7FEH7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="277" mass="30802" checksum="1FF737CAF8FB5B0D" modified="2025-10-08" version="1" fragment="single">MISDGPTTQYRCKTNFYLFATKLIDLDFSEGGSWNFMEAGYGKGAPDGVGAPLKRNADALVNTHDRDVICAADLVDGLQLQKSTILAVEVKENDVILQEQTIPLAVSPVPQTMKLHHITCKEKGVVSSRVLSCFCSENCSCYDPVTTRFDVNMHESSMTEGTTVSMLPESVSNKDSVLVVPVSLDESLIDRFCVVDYDGRPYPGKIVDVDDNNIEVSAMHCIGDNIFFWPLTPDVIWYEGVKVVTLLNNEPSLVTTRHRAIDKTVWEAIVKRWNFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHX1</accession>
    <name>A0ABY7FHX1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SRSF4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_002317</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd12337">
        <property type="entry name" value="RRM1_SRSF4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="411"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR20479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="549" mass="58515" checksum="E570473DFA5CD43A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIG8</accession>
    <name>A0ABY7FIG8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="12453" checksum="12A43ADF951F3247" modified="2025-10-08" version="1">MAIAQATVCKLKSECASSQCCYIKPEFEVVSKKRQSILPLQPISTHSDTGVCENYKLEGVPCWPLETMNGHCGCTPGTSCQFVPEPTLPAPTLVAIIQRSIYMPGPGSYQCVTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIR5</accession>
    <name>A0ABY7FIR5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TAD2B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_000727</name>
        <name evidence="10" type="ORF">MAR_002484</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02335">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041983">
        <property type="entry name" value="ADA2-like_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF63">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25299">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="64"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="64"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="7">
        <location>
            <begin position="65"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR18889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR20646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="448" mass="51043" checksum="35A9FCBCA7C42770" modified="2025-10-08" version="1">MSVFECNNCQSEIKGHGIKCLDCQNIDLCLQCFSLGAEVANHRSDHQYSISTGPVVGAFSCEVPWTLAEETMLLDAVEQFGFGNWEDVANHVESKSPEQSEYHYNSYYIKGNVGKATYQFDPTPKVTDHTCPDGPLSPSISTPVHPVDLSLPEQHALGYMPLRDDFEREYDNDAETLVSSLMVNYDDDDLDIERDRRKQFARDYGLITECAQAAAVTLAAATPGVKLAKSPHPKSPAVKKKQAKWDSDLEETMKPFAQCHSCKEHEEFLENHQKEKELKARIKELIHLRKNGITKLEELEKFEEERMKRDKKKDTKFKKLTNFPPQKRHSTGSKNTTAGSENFDILIDENEKPLCSGWSNSGDEDWKVVREMSHCPGYDLLSSTEKKLCNSIGMTPANYMTVKTCIVKDYLQRRNGFPVKLRYPSDQDKTHRRRIMSFLEDNGWIGHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJW0</accession>
    <name>A0ABY7FJW0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U4/U6.U5 tri-snRNP-associated protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_015831</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="11">
        <location>
            <begin position="117"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR21857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="173" mass="20944" checksum="13DB58664922511E" modified="2025-10-08" version="1">MPRSRSRSPKRDRKDRDRSRSRDRERHRRHRRSRSRSRDRRRRSRSRSRDKERRYDKDDRRERRDGGRDGGRDRGREDRSSSQHGSRGHGEESEEDEITFQAVNKNVTAEELEAMPEDEQELMKVMGFSGFDSTKDKQVVGNEHYCANITRKRRYRQYMNRKGGFNRPLDFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJW4</accession>
    <name>A0ABY7FJW4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_016479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="34"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR22505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="216" mass="24174" checksum="6457F8861DBFBF52" modified="2025-10-08" version="1">MPRLAATYVYGHITLKTPVLVRSPKLSNVEPGGDNAELYRNRNGYFSINVQAVCDANLKFTNIIARWPGSVHDIRIFNSRRLCGLFEMELTKNNCSEIYISETTDSKKETSSAQKVMQLSVGHSVCAGKGQEMACRFGFLIPPMKATMTFEPLDESTDIQENNDDEAKAEETNDIEANQLFPGGKIVLKNGVTICARRNPKVIRHKPNNESRNKMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLZ5</accession>
    <name>A0ABY7FLZ5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CTR1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_015730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF298">
        <property type="entry name" value="MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="614"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR21756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="891" mass="99708" checksum="43C0FADDC51E9B57" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FM55</accession>
    <name>A0ABY7FM55_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ENOF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_036974</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase C-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR23305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="109" mass="12378" checksum="ABC5EAB6096F1F18" modified="2025-10-08" version="1">MAAKFNVPVCPHAGGVGLCELVQHFSFFDYIRCSGPLENRMTEFTDHLHKEMCAPVKVRDGHYMPPQAPGFLVGIVPDIQKAYEYPDGSAWLDLFEKGLFKRDHDHEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FN82</accession>
    <name>A0ABY7FN82_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TM2D2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_016122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR22148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="188" mass="22028" checksum="8953A86A0163FDB9" modified="2025-10-08" version="1">MDYFKRIRKYYPLKDEVINRNLQIRPYESNMRSQYLSHECHFESSIMQYLCYLLGVLTVAFAQELEECFENCTEYRPHAPLVLCSPMEYLACIEPVDLNGNETRRLELDGFGCTKWGGERYEDVQKSKVMCIVLQGITCHGNRTFQKDGFPCIKYSSWKVDDTGRCWDLVDCGCRFAGDRFIETRTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTN5</accession>
    <name>A0ABY7FTN5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein axonemal intermediate chain 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">WD repeat-containing protein 78</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_037895</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Dynein axonemal particle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF12">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="248"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="712"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="712"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="730"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR24226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="740" mass="81422" checksum="93D1C3E198D9D3F1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTX1</accession>
    <name>A0ABY7FTX1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DMTF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_011359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051651">
        <property type="entry name" value="DMTF1_DNA-bind_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046775">
        <property type="entry name" value="DMTF1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380:SF2">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20588">
        <property type="entry name" value="DMTF1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="297"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="331"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="368"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR25655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="558" mass="62337" checksum="13BBA3DF4A56BCBC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FV39</accession>
    <name>A0ABY7FV39_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_038382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="201" mass="23110" checksum="21A3C20316C0EE07" modified="2025-10-08" version="1">MTLSQLVFVLMKLSQLVFVLMTLSQLVFVLMTLSQLVFVLMKLSQLVFVLMTLSQLVFVLMKLSQLVFVLMKLSQLVFVLMKLSQLVFVLMKLSQLVFVLMKLSQLVFVLMKLSQLVFVLMKLSQLVFVLMTLIFVLMTLSKLVFVLMTLSQLVFVLMTLSQLVFVLMKLSQLVFVLMKLSQLVFVLMKLSQLVFVLMTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FV62</accession>
    <name>A0ABY7FV62_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FUCL6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_038290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051941">
        <property type="entry name" value="BG_Antigen-Binding_Lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713:SF6">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713">
        <property type="entry name" value="FTP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="119" mass="13309" checksum="7100C5C1B0810B07" modified="2025-10-08" version="1" fragment="single">CHPHLRGAFFYEGKMNLKRKFIFSFILLFGKGFCDGNFEGQNVALGKTQQTDQGPGTLDGFKANLAVDGNESHSADSGACAHTTEGNDTYKAWWKLDLGQPYWISGIKIFNREHKQTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVQ2</accession>
    <name>A0ABY7FVQ2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR24979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="89" mass="10832" checksum="FB49115D538687E8" modified="2025-10-08" version="1">MLPVFAMYDLEHATFDVQMFAVRTNVSVPDNGHFRNSDRQQVFSRENDRRREWLAVDHHHLKDRYVQVVVEKTHMRVQPRFLLQVKLWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYS4</accession>
    <name>A0ABY7FYS4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="475" mass="52455" checksum="95EC135817E0195F" modified="2025-10-08" version="1" fragment="single">MVIDLGGGTAVISFREKKGTGTLKEIHQPTGGPWGGIYVDANYLKFLEHIFGEKAITALKTEERADFFDVIREFETKKRTFSKNTTGKITFRISSNIRKLSKKFTGQNLEQRICSLGFGESVIVKGDDKLRVESDIVRTWFDGPIDSLIGQIKSLLKKRKLRAVQTIVLVGGFGGSPYVHDRLRAAFPDKRLILSADAELAVLKGAAGLDGTRVTLALEPEAASIWCETLDVDTRAALAGAGTQYMVIDLGGGTADISIHEKNQDGTLKEIHQPTGGPWGGIYVDANYLKFLENIFGENAITALKTEDMADYFDVIRDFETKKITLNKKMTGKFTFKISSTAKKLSKELTGQNLEQRLDSLGYGESVVVKGDKLRVEPDIIRSWFDGPIDDIIGHVKSLLKEPKLRAVQTIVLVAYRTSIAIFRTTTENPVYVTDPGCELLGKLILELPRDMPLSELNTDITFIFGGTELVVKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G049</accession>
    <name>A0ABY7G049_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GA45A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_038400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024824">
        <property type="entry name" value="GADD45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10411:SF8">
        <property type="entry name" value="FI09246P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10411">
        <property type="entry name" value="GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="103" mass="11602" checksum="A4A818CEE4D04484" modified="2025-10-08" version="1">MGKCILDVGNALVHVVKEALSQGRVTFGIFECVEVLETCPEQVMLCILPTVSDENILNLVNIQHKLIEAHCWENEVNLVKEQQAFLSAAAQPNWLIKIRRTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0Q7</accession>
    <name>A0ABY7G0Q7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_012427</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR26723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="156" mass="18284" checksum="59D9F68CA5DFA144" modified="2025-10-08" version="1">MTVFPRRQSEVMASKYAQRMARLSSKIFGEVSRQTDQKSLKIVKIFTGLPPHLDPAKVDYYPRLRDTKTLTDDLRHHGLFIDEFLDFKEELVKKREASGKVKKVPYHIQKRLEKEAKAQESSENNWHHGFINQVETFKQVMVLKPLQTTDFVPGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1V1</accession>
    <name>A0ABY7G1V1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_014147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="129" mass="15211" checksum="A1EA1F6A80D038FA" modified="2025-10-08" version="1" fragment="single">PLKSTASEVSDQQVFLDDEFVERNRTKIDVAQSRLKKIQKMAKKNEKLVTTIDEQKTVINKSRDKEKSLSIKIENLEKECSGLRTCNHKRSNALRQKQKELDKKRKELQTLQNTIKLKDECLRKYYDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G283</accession>
    <name>A0ABY7G283_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BRAF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_011140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd20811">
        <property type="entry name" value="C1_Raf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01816">
        <property type="entry name" value="RBD_RAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003116">
        <property type="entry name" value="RBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02196">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00455">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50898">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RBD" evidence="6">
        <location>
            <begin position="151"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="5">
        <location>
            <begin position="234"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR25436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="475" mass="52894" checksum="F4FD527E0B0C9183" modified="2025-10-08" version="1">MAAVENLLNGDVNLYDRLGRMEADTIEILNEEIRNLENLIRLTKERLERLNAQFGRERHPPALYLQEYEELANKIHELQTQLQDKEQELTDIEAPPPKPPEPEPDPPTPVKLPIHTQIGNGTKTDTSVGGAGTEVPGALSSPNLAVKSPLGHVKAFLPNSQHTSVAVKVGKTLGEGLAKALKLRDFELDDCDVYDRRTGRQISWDEPMSEVAGYELTVELKLNRRQPSFPGVSYHNLARKTFFSLTFCDVCRKFLLQGFRCQTCGYRLHQRCKDNINPLCDTRNLTKHLLADSYGPFHPSLIPPSSYQSAALSQPPQQPFSRNKQAPLGPRGRSTSAPNVSFVNIGATEERVPRTVTLCIRISDTQVTAVPRRSQGLGGKSSRGIYCTCHGVLIIALLGAPQTAPPTPQRPQENSVHVLDQWKLTPAGELLILTEICRTNIIHVPLLIDSLSLNHIRYLVAHNMLVKALMTCRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2G3</accession>
    <name>A0ABY7G2G3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_011215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38332">
        <property type="entry name" value="PROTEIN CBG11604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38332:SF2">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047037520" description="Protein sleepless" evidence="3">
        <location>
            <begin position="22"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR25511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27632" checksum="3CCD346EE8BBA040" modified="2025-10-08" version="1">MRLADFMPLIMLPVMWNPACGLDCFECFSFNKSDPSCGDPFHPAYGRYTANCLQGREGRVGGFPSKYCIKLIAKDDIEMVYRGCSLTTLNNLCGEFRFENVRYHGCIMSCAENGCNGSSDLSVKLTSLSSFVGTGWFVEESYNYGLLGQRMLRHQSTQKPEYGHGGTISLSGCIRFGAVIPMETLGISWYGCLYSSLHMWLMICIFACDTLWKDRHAGYIFGVFLFGIYRGPAVRRDPDIDNLSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2R9</accession>
    <name>A0ABY7G2R9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_013403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tumor necrosis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471:SF13">
        <property type="entry name" value="TNF FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471">
        <property type="entry name" value="TUMOR NECROSIS FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00207">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50049">
        <property type="entry name" value="THD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="THD" evidence="6">
        <location>
            <begin position="111"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR27699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="271" mass="31106" checksum="6A82357D568ED2C7" modified="2025-10-08" version="1">MTDILLKRLTIVSVLLLLIVLITVLCIVWTMPDSKQIDANTNICLKHNNNNVQCGETTELLHALFEKEILSAYIEAETREKNQTKTYIEDALKHDVKLMSDYKNTLWDMKPSAKLVGIHEKQDHISGNNSMTTVTCWRHDKDLYYTTGFQRYGIRFQNGRLIVPVSGTYYIYSFLGLTERRLTDEGIPLESNNMHEIKHAMHKYNVLDTVDMEIASNLQSRKNASRGYFNYYASQISTLAKLHAGDEISIKLSDVTLLKHTGNNYFGLHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G316</accession>
    <name>A0ABY7G316_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_014279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR28575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="169" mass="18589" checksum="E27F10F55B06C3AA" modified="2025-10-08" version="1">MAERTRRVALVTGFTSEIGLGIAHCLASTGCDVIVQVLSSQSIIDDALTELRSQHGDCKISFVGANFFKEDEIDVMCMEVLKLYPGGIDILINNAARGLFHGSLAPYGGRAPNIRLHAHKMGNTVHEEKSLKIWIEFLSRVVLFLLLLDPDTDASFVQKQPYGGQVHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5A6</accession>
    <name>A0ABY7G5A6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="20" mass="2372" checksum="7DA2C29948C1FE65" modified="2025-10-08" version="1">MNIFLLTGMKMTLNDLKKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6N2</accession>
    <name>A0ABY7G6N2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045818978" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9300" checksum="F1E66CFC117C2063" modified="2025-10-08" version="1">MISLTVFVFILIINVLFGSLGGGGGIVMEAPTMAQVAAMEAPTTAQEVVTEAPVTEVAVVVEWWTNTENNPLHSEDLIEKRHTFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6S6</accession>
    <name>A0ABY7G6S6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="94" mass="10486" checksum="A90C744930F7E6C1" modified="2025-10-08" version="1">MTFTLERLPIDTVVRETCVPTKCDISVCLGRTCPAVPRAVCRPDGCGGCRDTWFLDNKLVDCLSDECPPRVPIIKCVDDPCKYFGHYCPTAECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7L9</accession>
    <name>A0ABY7G7L9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">KAPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_032945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0114">cAMP</keyword>
    <keyword evidence="2" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="5">
        <location>
            <begin position="116"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="527"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR30403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="566" mass="64685" checksum="7E78A943508F9309" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8F6</accession>
    <name>A0ABY7G8F6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LRP4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_003232</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR29664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="136" mass="14269" checksum="42CBC6C4F7606D04" modified="2025-10-08" version="1" fragment="single">RREPVHPASSAALPGNASAILWYVMAIRHAEMEVMRKAVRREPVHSASSTALPGNASANTCASGAFLCSSGKCIRESNVCNGSLDCPDGDDEVNCETRTCLTDQFRCSSGQCIGKSLACDGGLHCSDGSDEENCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9A0</accession>
    <name>A0ABY7G9A0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="102" mass="11335" checksum="A8183AFE80FC19B0" modified="2025-10-08" version="1" fragment="single">KCGSAKNDIRLHLHPFTSYRLECMSLSYCNVLERLQTLNPNPADWTATCCDGNLCNWNPMAGDRSVHHLVNTKPCPTSLTRPTTTERPTKPLPQTSIPASTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9A3</accession>
    <name>A0ABY7G9A3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FXL17-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="2">
        <location>
            <begin position="62"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR29783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="340" mass="38989" checksum="55C6982C75E59830" modified="2025-10-08" version="1">MNNTRKSSRTIPSVKRQKMEDVNTDEDDDEQQVESFENQLKDDDEIERNRNNCNNLVRQSNDRIQTINLTDCRLISSYGVLHLLNFATRLTTLKLIRCFDIMDSAFESAERQSLALRHVYLDGCCKVTDDALTMLLPSCPELRTLHLNQCPKITDRTMLIIARYCPKLQELQLDHCSRLPKLTNLDLSNLPRLTPDTVTYISSHCKNIRCLNLSLNAIINDDCLEALSKNLPGLWRLYCVSCCISDRGIAAVATNCPFLKCLDIGWCQDITDIGVKSVTSQCAYLEYLGLIRCDKVTLATMEQLVLKYPRVNFSTFILESRRLLERARREGYVFDVEISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAG4</accession>
    <name>A0ABY7GAG4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DRD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_033955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF47">
        <property type="entry name" value="ECDYSTEROIDS_DOPAMINE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="40"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR31413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="274" mass="31364" checksum="F09BD00D475B4DB4" modified="2025-10-08" version="1">MNNYTDYQTESLAELNDRYARALLPLTIAFGFFAVFGFLGNLIILLVFSLSRDYKRNNFKVFVLTLAVIDLVICIALIPAEMVKQRKYFEFGDVVTCKVKCFFQLISIDRFRKVVQPFKKQMSPAIAVRILIAVAGVFPILLAIPGTIMCGIKTTNMTNIHGGNTTIHLCETEEKYEKSIWRTIYKFTFIVLLFGISVTYIVLYTFVMREAAKQMKAISVQRTHSSPETVFTTGIYYQNTVCNETPETNRKQIGINENTAKWGFEPYGEHRTDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBQ5</accession>
    <name>A0ABY7GBQ5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HS3SA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF65">
        <property type="entry name" value="GH20068P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="91" mass="10318" checksum="84F5E54C864837F4" modified="2025-10-08" version="1">MDNKAFNTPPFMTERLLERNIPAHVGASFELKIHEDVKDGKCLKRLPKAIIVGAMKCGTGTMHEFLNVHPDIRSLTGENDFFINDTLYNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBZ8</accession>
    <name>A0ABY7GBZ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">YNG1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_033651</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="398"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="477"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="706"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="724"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR31109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="739" mass="84860" checksum="4D0F294C4B06790B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GEW1</accession>
    <name>A0ABY7GEW1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="305" mass="34581" checksum="318E24FBF8A15C7A" modified="2025-10-08" version="1" fragment="single">MRGMRLEIAAGLSQLSETRMPACLNYFKECNTFNWIQFTRSDNSFWTRMMWIRPSVVVLMIVLQTCGADRLERMERRLELKLKALQAYVEVIVNANEGDFVTLADRVSKLESIVSTSENDIRETTSNGSRNEHTIAYTKPELNNIQNTLTISEVKTELAINIEREIDDNNKTLIALNSQVRDYIANETESLAFFKTNILQDMNETRAHVRNETTELENKVEELIGRANEVVGIIDKQGSTIEDGIMVTIKALPGVTGLHGPTVLSHVTAAAKVDTGHVMYFRLLLKDFALEMQQKQRNASFTSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GF46</accession>
    <name>A0ABY7GF46_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045858571" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16737" checksum="097A0F1D607FADF5" modified="2025-10-08" version="1">MSIILNLVILAMVVHVSQAASLKFERELIQATTDTQAGEDGIPINDSRTYGFDDSPEVVDDDIDGSAICHKGICKISCVIAKAVHNAMEVKQSTFNESFGCFKIPNKADAMQPLVSLDSEDIDVETDYMDSENIDVLADSFGSDKDDVKADTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBX3</accession>
    <name>A0ABY7DBX3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LRP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_006733</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF5">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045071943" evidence="10">
        <location>
            <begin position="19"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAQ94262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="196" mass="22148" checksum="49DD98D66CF810EF" modified="2025-10-08" version="1" fragment="single">MAWIQFCLIAFLLPWVWQTLTSGSGMDGCRQNGQFSCPTSTKCIDKSLVCNGNNDCYFSEDERPPACGMDGCRQNGQFFCPTAQKCIDKSLVCNGNNDCYYFEDERPPACDMDACRRNGHFFCNDSRQCILKSWVCDGYEDCKQGEDEAPPACDLDVCRQQDRYFCNDSRRCISKSRVCDGDEDCKQGEDEDPSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDD2</accession>
    <name>A0ABY7DDD2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_006549</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040524">
        <property type="entry name" value="HECW1_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032348">
        <property type="entry name" value="HECW_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF320">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18436">
        <property type="entry name" value="HECW1_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16562">
        <property type="entry name" value="HECW_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="232"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="1014"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="1199"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="10">
        <location>
            <begin position="1418"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="551"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="633"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="971"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1041"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1254"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1330"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="605"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="761"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="867"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1041"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1084"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1339"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAQ94078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1717" mass="191701" checksum="9969AA7DC5A6DEA9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DES4</accession>
    <name>A0ABY7DES4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HPHL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_028113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="117"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ95423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="440" mass="50038" checksum="418A9F62A6082A93" modified="2025-10-08" version="1">MTTDVNFHFYFLFCFSLTCIATAFILDQPIPGSDVINKTDGSFNVRNYRDYYLRAEKVLWDYLPLQENVVDSYTEYLEDTLKNKNNRVGSKYLKYVYKLYTDGNFTQEIKSPPSFGYVGPLLRVEVGEVMRIHFRNDVDMPVSVHPHGVKYTKINEGAQYMDGTNGASKSDDGVPQGTDYLYTWELTSDFSPRDDDPSCIPFAYHSHVDPEKEVNSGLVGLLLVCKQVLTERCISYKIVSPMASALDGGRAWWRNPKLLRNFLGTLRADGTRSDVDSEQVLYFDSIDEGATWLTDENLKRCGDPDECKRLYESGDPDFEESLKKDSINGIIMQLNFLNDLRLTEMGLTELQRSGKKQYKLIYKKLTENSRNSVNGYMYANLPNLTVCAGDRVAWYIFSLSAEIHTVNRDRYLASDVSRNGNGGAESGHVARAVYELGTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DF61</accession>
    <name>A0ABY7DF61_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KLF18-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="entry name" value="Serralysin-like metalloprotease, C-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="Adhesin YadA, collagen-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="226" mass="23722" checksum="8F4CCD36FC531D90" modified="2025-10-08" version="1">MLYGDGSTDGHDNDMLYGDGSTDGHDNDMLYGDGSTDGHDNDMLYGDGSTAGHDNDMLYGDGSTDGHDNDMLYGDGSTNGHDNDMLYGDGSTDGHDNDMLYGGGSNDGHDNDMLYGDGSNDGHDNDMLYGAGSNDGHDNDMLYGGGSNDGLDNDMLYGDGSNDGHDNDMLYGDGSTDGHDNDMLYGDGSNDGHDNDMLYGDGSTDGHDNDMLYGGGSNDGHDNDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DH03</accession>
    <name>A0ABY7DH03_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">ACHA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MAR_028908</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Synaptic cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="15">
        <location>
            <begin position="110"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="16">
        <location>
            <begin position="357"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAQ96218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="591" mass="68224" checksum="1307A8B8A3714655" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIB1</accession>
    <name>A0ABY7DIB1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="19">SC24B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MAR_030116</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">MELC-2E11</strain>
            <tissue evidence="19">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="15">
        <location>
            <begin position="610"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="16">
        <location>
            <begin position="683"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="18">
        <location>
            <begin position="926"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="17">
        <location>
            <begin position="1021"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="14">
        <location>
            <begin position="1152"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WAQ97426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1274" mass="138816" checksum="B26AC270284E3F08" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJ97</accession>
    <name>A0ABY7DJ97_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MO4L1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_022155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF48">
        <property type="entry name" value="MORTALITY FACTOR 4 LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ97782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="441" mass="49816" checksum="B555E9C1CF23CCD4" modified="2025-10-08" version="1" fragment="single">MFNIATAVMKNELRERALHYFVHYNGWNKSWDEWVPETRILKLNDAGLQKQKECFDALKAEKARNREKAREAREAGLPLPSKKKKKEKEGGPRDRAATPTTDVKSKQKAPVAKSKSRGGDTTERSAKLRGDGDKDRSSRASTPTSTSSTSKKSSKDSEKERTSRSSTPTIPQPAKRQKVERAAASAAASQIAQQAQPSTPALPTPQPPSQPSTQETPTPATPASQASSEQKRKRARLDQTIESEESYLAKIEVKVKIPEELKPWLVDDWDLVTRQKQLVTLPCKHTVDSILDDYLQLKLTKPNHPNRDTIIEVNNGIREYFNAMLGTQLLYKFERPQYGTILCDSPDKAMSSIYGATHLLRLFVKLGSMLAYTALDEKSIQILLHHIQDFLKYLQRNASSLYNLSDYHVASPEYHRKAIRGRPLVTLILNRYEDSQEHLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJU7</accession>
    <name>A0ABY7DJU7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GAWKY-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_029834</name>
        <name evidence="6" type="ORF">MAR_029901</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052068">
        <property type="entry name" value="GW182_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026805">
        <property type="entry name" value="GW182_M_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13020:SF25">
        <property type="entry name" value="PROTEIN GAWKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13020">
        <property type="entry name" value="TRINUCLEOTIDE REPEAT-CONTAINING GENE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12938">
        <property type="entry name" value="M_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="568"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1153"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="696"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="836"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1051"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1237"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="851"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="892"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="924"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="954"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="987"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1052"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1078"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1237"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1251"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1264"/>
            <end position="1280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ97144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ97211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1322" mass="139804" checksum="1D59C935BE4935DF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DK72</accession>
    <name>A0ABY7DK72_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GALK1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_030283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="6">
        <location>
            <begin position="21"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="4">
        <location>
            <begin position="110"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="5">
        <location>
            <begin position="293"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ97593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="676" mass="74918" checksum="4146FC04D4D10DBD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMM5</accession>
    <name>A0ABY7DMM5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FRPD4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_022511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17088">
        <property type="entry name" value="FERM_F1_FRMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221:SF3">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="3">
        <location>
            <begin position="207"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="883"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="963"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1267"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1364"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1512"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1580"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="723"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="888"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1282"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1320"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1368"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1390"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1412"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1553"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1580"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1610"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ98138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1922" mass="212050" checksum="ADF276A288983A97" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DN40</accession>
    <name>A0ABY7DN40_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CP1B1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_022389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF1">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ98016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="332" mass="37776" checksum="2CB2263D9D32B6A1" modified="2025-10-08" version="1">MAKYPAVQKCIQDGIDCTVGQTNMPCLDDKPHLMYTNAVIHEAMRIETIIPTSLPHYAMQDSYIQGKKVDKDTVVLFNLHSLAHDATVWRDPTNFLPDIFLKEDGDLDIKMLAKSHPFSLGHRRCTGEQLAIMNIFLIFSGLMKKYTFELYENAEVATIPGLVYAPDKFKVTSDLQLRGFIITKAYPDGPWGFPIVGHLPWLGNDTQKTFADWQKRYGDVFRIRLGSWPTVVVNGHKAIHDAAVTAGDAFFGRPNFVTTEILRRRTGDDPFAFGTFSPAYLHQKKITTHALRLFTKDRKEFVEELITSEVETLTTNINQALFQMTFILLLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNE6</accession>
    <name>A0ABY7DNE6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ZF-HD dimerization-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24735" checksum="E597E177D4A6DD6E" modified="2025-10-08" version="1">MFYPMPNIKTMSDYIHPNHGYPSIVETDNVPSILQNSQEETIGGQHASVTTYTEFERPTERQDVTDEGNENSELSNEIVVNVNGRECQQESSQDGTTEALVISGSLTEHRLISGSLTEHRRERIAQRNPVVALPALATVTSNADVGFGKYADYRRRLKSFKGYAKKWPHRNPSAKDMARANFIFRGSDRHPDAVQCYLCGNTFHTIQETDVPDNLCNCNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPC4</accession>
    <name>A0ABY7DPC4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ANMK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605:SF0">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="381" mass="41934" checksum="59A9F8B3344496E8" modified="2025-10-08" version="1">MASFVGVGCMSGSSMDGLDICCVEFTGDIFTDLWGYRILAAETVAYSKQWSERLRDADNLSGIELIRLHVDYGRFQGKCVSTFITKHRLNERVQFVASHGHSVFHKPQEGISFQLGDGEVTAAMLKVPFVCNFRAKDVTIGGQGAPLVPCGEKYLFRNSDICINLGGIANIGIKGMRGYDICPCNRILNSLVLEKGGGQQYDKDGDLARSGDMVPEVLVKLQNLSYYQQDPPKSLWVDYIEENVLPILDCNKYKVENLLRTCTEHVASMVADACFEAKPSIATTSHHPNRTVLITGGGALNKYLVELIGQYLDAQGFEIEQVDEETINFKEALIFAFLGMRCLLGEDNVFSETTGARQDSVSGSIHRPLSSGSAKHISLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPJ8</accession>
    <name>A0ABY7DPJ8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="12486" checksum="6A1D957E4EAEB3B1" modified="2025-10-08" version="1">MRQTLMAKRDPDARPVSFQTIHAGCRVKVPCSGEETRLTRPAYIHARLSFCNEHARLNREQWRTVLFSDESRFYLWNVDGRLRVWRRRRERHAHCAVIPTVAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQG9</accession>
    <name>A0ABY7DQG9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ98809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="84" mass="9112" checksum="C03D0CDA0C8896C3" modified="2025-10-08" version="1">MSTDVGKLVNKTAKMLGVPRNVVFPIKNYEHEMETLDSVNSLALFALKTMVEMATDHLANLQAVKGAEGGEDIYPEIGNMSDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRA5</accession>
    <name>A0ABY7DRA5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LRC49-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_023499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF8">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ99126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="237" mass="26996" checksum="4F7003D1A14BA25B" modified="2025-10-08" version="1">MLKKLPLRPRTAPTRVTRLGDDHMAEGNVPFYVVWVRCMPNTGDRVIFAESPSAPGIPVVYRTPEERSSNPDRLNLDRRKLTVCPILEGEEQLRLLNYQHNGIQKIQHLAALKRLIFLDLYDNQIEEISGLSSLRSLRVLMLGKNRLQRIENLESLVKLDVLDLHGNQIACIENLNHLTELRVLNLAGNAISYVNGLKGMDALAELNLRRNKIRTVEEVDTLPKYDLSTFKLLLSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRX9</accession>
    <name>A0ABY7DRX9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NIPA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_023808</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIPA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ99435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="413" mass="45049" checksum="BFEE4715B110E1BF" modified="2025-10-08" version="1">MATTLLPTPVPGANGTPIESTTLNFTGNTTVWTKQTEEEAIQNFWIGLGLAVSSACFTGSSFILKKKGLLNASRKQVILGEIMNFMAYLFAPATLVTPLGALSVICSALMSSYFLNEKLNLLGKVGCLLCLLGSTLIVVHSPEEQEIQTMESLKDRILEPGIIILSLCLIAIALVSMFVLAPKWGQKNVLVYVSVCSTLGSFTVMGAKGFGVAIKETFYGRNEFDNFLTYVMAAIVIGCSLIELVYLNKSLDTFNTAIVTPTYYVLFTSCAVMFSLVMFKEFGRMTLEDIIGALIGFMVIISGIFLLNAFKNMNVSLRNLPKAQKRPTSLSSQNGDVMTQVAHDDHHLLEENENLSHDEEPVALGDRSHTGIYEDDPESPVYSDLNKMTEGLTTDSNSNISYSSNVNTSLVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSC2</accession>
    <name>A0ABY7DSC2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secretory carrier-associated membrane protein</fullName>
            <shortName evidence="5">Secretory carrier membrane protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_024979</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007273">
        <property type="entry name" value="SCAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687:SF2">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04144">
        <property type="entry name" value="SCAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR00607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="411" mass="45719" checksum="92FFD5984707EF38" modified="2025-10-08" version="1">MTIDPPAEIDFEQLEAKSPRKGWTHQCSKLEVVARDKLAGQPTIPPPQSSPAIMQPSSDAPPPYTQSSAQRIDTSELERRQQELEKKAEELARKEQEMKNMQFQDRQNNWPPLPGWFPVGPCFYQDFSVDIPLEFQRTVKIIYYIWMFYAFTLFLNFMGSMAYFIVDSNGGPTFGLSILWFILFTPCSFICWYRPVYKAFRSDSSFNFFVFFFIFFFQFCVCVLMCLGITDFSVGIIGGLRVVGQNVVVGLIMILVGIFFGALATLMLVLLCKVTVEIGWINGLRTIGKHLGAGIFMLIVAFFLSVISGVKMFIGWINSLKTIGGNLAAGLVMLVVSLFFTITAVVSIVMLIKVHRIYRSTGASFAKAQQEFATGVMKNEAVQQGVSNAASSAAQGAVRGAASQYGTGGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DV89</accession>
    <name>A0ABY7DV89_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AB22G-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_007923</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF63">
        <property type="entry name" value="EARLY GENE AT 23, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="561"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="22"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR01365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="591" mass="66945" checksum="4C76FF370D45A95C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWI4</accession>
    <name>A0ABY7DWI4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SERIC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_025428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR01056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR01056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="648" mass="72501" checksum="74C019EBC8BC4184" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXX8</accession>
    <name>A0ABY7DXX8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="142" mass="16333" checksum="750914BBD56FC594" modified="2025-10-08" version="1">MMSSLVPGSIFSASGFNRKSTPTPPNVTPAELDNRYKRTNFNGTEWPHDSPVARAYDNSTRLRGYYTGPKKPDRYVDPERHRAKSPRFHPEWHDRCLDSSSPKFEPTVRSHLEWVNSSERPPNALIECVESIQINQNSMKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZM1</accession>
    <name>A0ABY7DZM1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="837" mass="78924" checksum="9CAFF68257D392C5" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1I1</accession>
    <name>A0ABY7E1I1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">U1 small nuclear ribonucleoprotein C</fullName>
            <shortName evidence="9 10">U1 snRNP C</shortName>
            <shortName evidence="9 10">U1-C</shortName>
            <shortName evidence="9 10">U1C</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_009602</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the U1 small nuclear ribonucleoprotein C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03153">
        <property type="entry name" value="U1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR03044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="150" mass="16148" checksum="EA33B42B356DE134" modified="2025-10-08" version="1">MPKYYCDYCDTYLTHDSPSVRKTHCSGRKHKENVRLYYQKWLEEQVQKLVDDTTAAFKAGSSGPKPGPMPVGPIPGPPGMVPTVASMGGPMGNPMPLMGPPRPGPMMMPGMRQMVPMGGMGGMGMGPPMQFRPGGPPMMGGPPGPRMMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E215</accession>
    <name>A0ABY7E215_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_009022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045661944" evidence="2">
        <location>
            <begin position="23"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR02464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="246" mass="25203" checksum="5944D731943C729E" modified="2025-10-08" version="1">MLSACLLTTAIGIVATIQQAFANVGTTCTANGNECVSLTGAYCDLDADGGAKCACAAIYKASDDGNTTCIPKNCAVGNAVASNSVCRARDSKSKCDGDVCICKPTFVLTGADDSDGCALVIGSSCAGDFDCEHIQHAVCPTIAEGCACPATFTASKDRLTCVPNKIGANCTMEGEIGSTCTNNGDCTEDTTCATSDDNAICSDKKCGCDVTFEISNSKLCQKRDNAIGPAVSVILLFTCFLSTFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3V7</accession>
    <name>A0ABY7E3V7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="85" mass="9188" checksum="0BC37F8D09588C44" modified="2025-10-08" version="1">MDDDDENETEIPEDDDEEVALEKVGGVETEEVMGAAGIEVDAIHIEISKGETTSRIKIVEVAVYAAVAADAKKFETLVNITTNHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4M0</accession>
    <name>A0ABY7E4M0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HARB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR03917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="242" mass="27536" checksum="4E7D11030DDA23C5" modified="2025-10-08" version="1">MVGVQGRLPWIQLGWCAVATPEDPSWMMALVFLGGDGNRRRHNIPMVFRDRMNPLDVMNDHEIIKKYRLDRDAILEICAQTQQHLVRPTSRSQSLPVCLQVLVALRYYATGSFQSVLADGHGISIRSVSRSIHAVSKALTRQVPRQIKFPTTRAELKRTKQLFHDISGFPNVIGAVDGTKGFHAINGQGICSADNLFINIVVRWPESTHDSFIWNSCECVRMMCTKNWIYRMHGFWAIVRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5Q0</accession>
    <name>A0ABY7E5Q0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RIHA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_020729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052775">
        <property type="entry name" value="IUN_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190:SF1">
        <property type="entry name" value="SI:CH211-201H21.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190">
        <property type="entry name" value="SI:CH211-201H21.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="2">
        <location>
            <begin position="107"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR05360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="234" mass="25989" checksum="0A5FE7C131479F83" modified="2025-10-08" version="1">MATSGQRKLLIDTDAGVDDAQAILMALKSPDVDVIGITCVAGNVDAMQVGKNVLRVLQVVNRLDVSVDYYHGSDGLGDVPDPEAPDKSLIQSEHAVNALIRLSKKYKGKGNITVAAEFNFYFDPEAAYVVLNQLKAPITIVTWETCMEHSIPWECYFNLRDKGGDVCKFLSSIEKKSCEYAQKQKWTTFISADVFIISCFLWPDVIKTCCDVYATVELKGQYTTGQMVVDWQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6E8</accession>
    <name>A0ABY7E6E8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="76" mass="8671" checksum="BC93429AE0E67BD1" modified="2025-10-08" version="1">MSFNRNAENDWHEMFNSIAMYSAISVGVTDMNVQSAWHAVFLKSGRMCKVPEFTGWTVANGRCRETFDPPQQRSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7E3</accession>
    <name>A0ABY7E7E3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="72" mass="8486" checksum="3FF86A3FCA15CB8F" modified="2025-10-08" version="1" fragment="single">EMNKEHFLSFVQCLKSVNDDRNLEQSVSMIYVIVHVRVTVNSSDRRYHGYRRFPASARPYTTVHMPGRQQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7S3</accession>
    <name>A0ABY7E7S3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_020381</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd19776">
        <property type="entry name" value="Bbox2_TRIM25_C-IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="5">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR05012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="568" mass="64869" checksum="7ECF4DDF2C3D8CD2" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EA50</accession>
    <name>A0ABY7EA50_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ISCU-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_016878</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="3">
        <location>
            <begin position="25"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR06920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="152" mass="16358" checksum="22F8E14387F044E3" modified="2025-10-08" version="1">MALLRNLPKIIPQIQRGSASTVALYHKNVIDHYENPRNVGSLDKNDKMVGTGLVGAPACGDVMKLQVKVDDQGNIVEAKFKTFGCGSAIASSSLATEWIKGKNVDDAAKIKNTDIAKELCLPPVKLHCSMLAEDAIRAAVNDWKVKQGKTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EB07</accession>
    <name>A0ABY7EB07_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_017178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR07220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="380" mass="42813" checksum="B7372394FE6A9470" modified="2025-10-08" version="1" fragment="single">MASTTTVSPRAQAAANGTIVLPVWSIYVLACSLFIVVMAIVTLIVCRWKKKRQKRVVKPLPTGEASRRLRNELNNGTATQQTFEYFLAVPSTGVRILKQNNVEPHSRPLSESDRDSALLVSESSKFSHDRRVKDVNSINTHKAKENMFRSDEEEKGIERLVVALTQAQKENELKENTEPDNKRMQRKIKKKSIATKLGHMQKSADSTAHNHKHSPNLKHVSSTSSDKSESDIDSSFKSEQHDLYSDVSGRTADISGNDCSTSDDNSSTLSKSSREFIKANVRRFQRQNLREHLFNELAEAEQNVELLKVSRRNIPSGAELIQTIQQTSIHQCVNLDDEILPKRDGPLASSSFKCEYRKANSDMKVNEVAKNDNSKHKQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBU3</accession>
    <name>A0ABY7EBU3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_021542</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF32">
        <property type="entry name" value="PROTEIN TURTLE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="105"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="367"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR06173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="504" mass="55897" checksum="82C12517F0AB3BEC" modified="2025-10-08" version="1" fragment="single">MGTNGETVSQSANLKLICTSTRNDIKCVRWYHKTHDGTCEFDPTYTVPANMKCDCMNISMYTCTLISVQEDIRGDMWSCRFAYGTQNMLKFSYTNTLTIDLADGPKMRILQDISVVQGGKFEYPCLYEPGNPPAVSFEWTRSESVASWIKQEKQNLTISTVQRSDEANYTCNVSSILRATLGKETLKYDTATFHLNFYEFDITGVVSDGAENLKLRINNVSNASVEIEENTTNHIQCSLESDPASNITILKDGKTMIESHGVHQLTHEIKPECSDTGVYTCSGYNEYGAAENASIYLCTEESDGSCYRLSDKVRKIDIVTGTPTSSLTILDIQIEDYGMYQFSVHNDIGSPLIEWLHLKPPIAKPDPPSDFHVIQEEISETSAVLAWVPGFDNGSPQTFYITYGKKGDSSGWITKSVEHTYEAKINYTLRNLETETEYIASINASNEKGSTTTINDITFITLKHIPGVQTHFPTALIGGAVGGGIAVGLVIIGLIFLVKKMRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEJ4</accession>
    <name>A0ABY7EEJ4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_017310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="243"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR07352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="675" mass="72600" checksum="35F933FBBE79A737" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEL1</accession>
    <name>A0ABY7EEL1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd21090">
        <property type="entry name" value="C11orf65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33504">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE) 1 BETA SUBCOMPLEX, 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33504:SF2">
        <property type="entry name" value="PROTEIN MFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="569" mass="66361" checksum="3D4CA6E98C046253" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEV4</accession>
    <name>A0ABY7EEV4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">exodeoxyribonuclease III</fullName>
            <ecNumber evidence="4">3.1.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_018513</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="4"/>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF26">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="239"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR08555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="922" mass="103909" checksum="F16078A2A454108A" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EF02</accession>
    <name>A0ABY7EF02_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MSRE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_017588</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAM" evidence="4">
        <location>
            <begin position="34"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="5">
        <location>
            <begin position="224"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR07630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="502" mass="56554" checksum="1156C003B686F5E0" modified="2025-10-08" version="1">MTKAGTPKIGDSFTTLVKQRPTSRKDMVRALPTDICSFEAGTCGWRNVLEEDDIDWSFGDCSYFIHGNINKNGIGYQQQNTTDNCAYIESFGPHSAGHRAMLRQAVMIKTPVVISFQAFINTDAGNFRVFLNTSDKYHLFWKSNDMKRDTWEYQQINVFGKESPFWVTFDAERAFSQNFHHNKVAVDDIAVNHINCKYLPCNSFRACRSCYIRFSINFFVIQNIQLVDGPTPMSGRVEVLINGQWGTVCVDPDDIFFATVVCRMLGFATNNAQILSLPWGQRGTETQPIWLNRVICNGSERRLEECRSSRYDLNDCTRSDDVGVSCYNRTDTTTTPASLQEDEPGSHTNNNIFIIVCSSIAAGMFSISLCCCGYCLHRYQICSKDATGQQISQTQYEVETNANTTITANTLQSDGTHPKPDDQPPPYSETCFLPSNDGYTIQVHYHLLSEPPSYDYVMASPCDYNIHVAVGYRPDKRSCQKGSSLSIQIISTRALSQPTFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EG48</accession>
    <name>A0ABY7EG48_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd22823">
        <property type="entry name" value="Gal_Rha_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045897602" evidence="2">
        <location>
            <begin position="16"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="418" mass="46262" checksum="494EF352B24FE152" modified="2025-10-08" version="1">MIMMLIIKHAIVLFYQEVPPLRDGWRTATACFGSDIKCSQYELQCPPGSHIALGRLWYGRKTGIEVCLFGVSNCNTTAARVCCNYNSRDEFWEFTEANRSSVVERCEGKQSCKDWAPRSSSTPSSHYVYMTYACLTVSNSVGMCTQTTLTSNSLFLEFNLSQDYKLPSLINGTNDCSCRITAENCHAKLNMTTSTSSASSDMSSESRSTHFVSTNGADETTTIATKDTNGGNKEGLIIGITVAVVLIILILVAIAMLCLCVRIKRKEAVRRDSIRNTNIFYSFPQDLEDTESIQCSNAVSTPREATMFPADLFQPDLGTNIKAPKESTVGRLQFESYTNEHVTKDQGIYSENNGEFSRMPNDSFASETSEETIAFDNETVHIMPENGDVKTSMNGVKSVSFDQNALYAKVIKEGKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGW9</accession>
    <name>A0ABY7EGW9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PIAP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_019063</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="721"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR09105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="769" mass="87433" checksum="7ED73C05B0E653A9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIB7</accession>
    <name>A0ABY7EIB7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IBTK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="47" mass="5219" checksum="FFFFF733CBC62CED" modified="2025-10-08" version="1" fragment="single">MEYLYTNDAKIIAECADAEKLCNILVVADQMLSVRLKQMCEVAIAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIT8</accession>
    <name>A0ABY7EIT8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="232" mass="26206" checksum="C40C64F86CCB6685" modified="2025-10-08" version="1">MLFIEENNCKSLQVAANGTLSSGTYTVQNSLCQSFRIYCLFKEGYGYTFLSSNTNVTVNMESLYDDKTHILVRFTKANKQYESTLAQIDTFASVPLSIQYNSYIGYNEPHNVNMTPYIYVGFIPASNTSKGARQGWKTNGQEQFFNNCDANPNSYIMFMFNHEKRGYTDYVGGKNSLLYKWYDNGKEVLSLSDYVPDEFFTSYHEISHGGCGGYSRGSNVPTTANVGMKFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJH5</accession>
    <name>A0ABY7EJH5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF18">
        <property type="entry name" value="SHORT-CHAIN COLLAGEN C4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="189" mass="21092" checksum="C0F38A7C0BDC5F76" modified="2025-10-08" version="1" fragment="single">QSVLLTQDGGEPLVLEMDPILCTKVTWQGHPWMITQRTAKVPTTFASVIHQYGTTTVKEWTTASLYPESNTLSIRIIILRPYHSFFGSNIEQGEAPCAICKVIRGTLIMIPGRKDCYPGWTKEYSGYLVGGYPGYGDSSELVYLDRRPEVLLDDGKFQSEKELFFVEAHCNGGLTCPPYVNGRELSCST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKN5</accession>
    <name>A0ABY7EKN5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="79" mass="9244" checksum="A98B74BF839468D0" modified="2025-10-08" version="1">MVPKPDARPTQECATRSEKSRTTQTTIGRWLGNQKELKQWEEVIAANFNHKREVKDLRSPENKLNDTHDINQEEKICIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMF8</accession>
    <name>A0ABY7EMF8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="819" mass="94296" checksum="1EA21FCD9E73C70B" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENE1</accession>
    <name>A0ABY7ENE1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="275"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="324" mass="38177" checksum="D5311F7EC6B88683" modified="2025-10-08" version="1">MEKLFRQDHSDVYFNNERLNEDLNGKIDEMKKDMYRQEMRRLTEIKLLQQEIKEGQEPGISGSLRTKSSRPTNRKRAQSAWARTGSGEKKERAEDEKPEEVRSPSPASTVSTLRNTRTLKRYQNIGAQRFKENGRFPEEWYIKCIPASDASVHNARMQFNKKKAPSPFNFLAKIREHEMTEKKLKEYTANVKIAKNGAENNEDEIDGNQMILMCEEPVKPVQTGLSRRQLRKIANDTKIERGPSRNTEKRLALVAINEQENKKIFDKVRVFCKKIEDLKAREIRKLREREEARKREEEERAYHEVIDEALKEEENTQCKSDEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETF7</accession>
    <name>A0ABY7ETF7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 186</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31687" checksum="A8C375733F25FB1D" modified="2025-10-08" version="1">MFLFTVSTLPLRQASTLGHKNAAKKVYRLFVQRAHGKCPVTFHQRFASNAPNLKSHPSPDSSVAKLAAEEIPVSSDIGKKHIVPMYDVDKVSRDCHIIYHRRLYLIGIKQTFYVSLGAFAMLSFGTFVCMNSGEAEDVLIPLLDIEVPDILLGYVCLISFMIVNVAFNLYRQNKLSVIRVYQTPKPDRYIAIVIDGLKKQKTVEFGLDDLTPTNYGRKIKKGNAKIGDRIVALHLDDFINDSYYNKLFKLEKRPINMKRKTTTLPRTEEARITNDKCDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETT4</accession>
    <name>A0ABY7ETT4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HS12B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_025989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR11809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="399" mass="44084" checksum="B6AF1C8FA9B54F42" modified="2025-10-08" version="1" fragment="single">AGLDSDRIRLALEPEAASIWCQQINTSLKTDLSKAGSQYMVADLGGGTADISVHEKNVDGTLKEIHKASGGPWGGTCVDHNFISWLTKVFGETTMSRFREEEMEDYIGLLREFEVKKRMITPETNGRVTFRLPIAIRTIHDKAEHQSFDQKLERLKITDGIALQGDKLRVSADTVKSWFSDSINQTTHHMISLLSDAKMKGVSTILLVGGYGECKLVHDSVTKKIRNKNIIIPQEAGLVVLKGAVRFGHMPGVVTSRIVKFTYGFAAKVNFDKNIHPIQKKITGSYGEEKVADAFCKVVCVDTEVHIGIPIKVPMKNYLSARAGTVLRIYTSPMPKPVFVTDAKCKMLGEVALGNAKGNSKEENEVEINFLFGETELEVRVKMLNDGSEIKKVIDCLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EU66</accession>
    <name>A0ABY7EU66_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_027687</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="10">
        <location>
            <begin position="2"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR13507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="337" mass="36711" checksum="DF1A978F1B457E7D" modified="2025-10-08" version="1" fragment="single">DPRVLDTMLPYLVSYYGNPHSRTHAYGWETEAAVETARKQVADCIGADPREVVFTSGATESNNISVKGAARFYKSKKKHVITTQTEHKCVLDSCRALEGEGFEVTYLPVQTNGLIDLKELEAAIRPDTVLVSIMTVNNEIGVRQPMEEIGALCRSNKVFFHTDAAQAVGKIPMDVNKMNIDLMSISGHKIYGPKGVGALYVRRRPRVRVEAPQSGGGQERGMRSGTLPTPLCVGLGAACELAMQEMEYDHVRISRLADRLIDRITSQLPQVIRNGDPEHSYPGCVNLSFAFVEGESLLMALKDIALSSGSACTSASLEPSYVLRAIGADDDLAHSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EU91</accession>
    <name>A0ABY7EU91_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">alanine transaminase</fullName>
            <ecNumber evidence="8">2.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_027693</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-alanine + 2-oxoglutarate = pyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:19453"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="94"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR13513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="428" mass="47681" checksum="51823A469395EC30" modified="2025-10-08" version="1">MHSLKMYRATGGICKLQRVFGAAQCRTKVLSVENMNPHVKKMEYAVRGPIVIRAGEIEEELRQGVKKPFTEVIRANIGDCHAVDRLLNDPNYPSDAKERAQRILNSCSGQSIGSYSDSSGVRVIREDIARYITERDGHPADPVDIFLSTGASDSIKTIMKLLMTAKDGKDRAGIMIPIPQYPLYTATIAEYNAYPIGYYLDESNTWACNIPELKRAIKEARSECKPRAIVIINPGNPTGQVLSRQNIEEVIKFAKEENLFLMADEVYQHNVYAEGSAFHSFKKVINLDPAVKVMQLKSISAKLCSSVSGQAVMDVVVNPPRPGEPSYDLFIKEKDFVLGQLKKKAEMVTKTFNSIDGISCNAAGMKPDAFYCFQLLEEAGICVVPGSGFGQVEGTFHFRTTILPPLDKLTGMMEKFKVFHENFINKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWS9</accession>
    <name>A0ABY7EWS9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proline-rich transmembrane protein 3/4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_027054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059081">
        <property type="entry name" value="PRRT3-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052836">
        <property type="entry name" value="PRRT_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35578">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25987">
        <property type="entry name" value="PRRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Proline-rich transmembrane protein 3/4" evidence="9">
        <location>
            <begin position="58"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR12874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="376" mass="42175" checksum="E3FA93FB97FF6B13" modified="2025-10-08" version="1">MPVAEGTPEGEAEVGPEPEKEISPEPEVETGPEPETEIYPEPEVETEPEGEYDGEVGRAEAEPDWPLAFKQWGPAWQLHVYFFASIFMCIAILSLMSMTFYLRDRRRLRQGILTFTLQCLLFLFTLLRTLSLFINPYLTVYANEETAFTFLWSLALPSLTAAFSVLLLVFLDTTKMTLGPPIFQKLPVLLGITAAHFLIVMMSEVVCYVTPGSCKPMLMFCQCLFVLYGLLLGAGYLYTAIVVHRKCSSGALNSDQDKIRRIIKISAAASITAFSVAITHVYSACSEFGIYSNVTYVDAWSWWTLQTLLRLEELSSACIILVIAFRNPLDVDSKVYTWLMGVMKTSKVASSDNEKNKPPISSNLPHNVKYTDVEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXL9</accession>
    <name>A0ABY7EXL9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CDC42-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004113</name>
        <name evidence="4" type="ORF">MAR_004132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR14008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR14027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="154" mass="17178" checksum="4F99F6E418807F25" modified="2025-10-08" version="1">MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLIDLRDDASTIEKLAKNRQKPVSGDQGERLARELRAVKYVECSALTQKGLKNVFDEAILAALEPPEPQKKKRCRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F032</accession>
    <name>A0ABY7F032_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MDH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR14256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="130" mass="13396" checksum="4C86617AB9DB31BC" modified="2025-10-08" version="1">MADVAAIVHLPELRAFVIRCMASLGITETDGGALAELLNGTTATSGSPSVIKETVATYLVDGCNVLGSNHFGIAGWYGLRAMEQGMVGMSFTNTSLGMVPTRAKENVLGTNPICCAAPAKDGDGFVLDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0E7</accession>
    <name>A0ABY7F0E7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCR4-NOT transcription complex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cell differentiation protein RQCD1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_004924</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR14819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="224" mass="25220" checksum="3F300BED988530EA" modified="2025-10-08" version="1">MKELKSRTKNCIVTSRMMNPGAAPPTSGSGSLMAGSSMSQDEREKVYQWIGELTSPDTRENALQLNIKKREVVPDLAPMLWHRFGTVAALLQKIVHVYPAITPPHLTAHQSNRGCNALALLQCVVSHPETRSAFLTCMVTLYLHHNRKLLYYHRRHFWSVLLIMHVIGDLLIAVGNGFLNVYRHLVSEALRLCFTDQLKDSTFVNCLNDNNYTAPAKPRKSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3M1</accession>
    <name>A0ABY7F3M1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TENX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_031354</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046526370" evidence="4">
        <location>
            <begin position="21"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="683"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="226"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR16760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="786" mass="85485" checksum="61CF6CE0185B6EFD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F460</accession>
    <name>A0ABY7F460_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="547" mass="57456" checksum="C3C94E89B0D3EFA7" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5A6</accession>
    <name>A0ABY7F5A6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EDIL3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_031956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="187"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR17362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="476" mass="54624" checksum="A982C3AA9800DFF1" modified="2025-10-08" version="1">MTAYPKYRTILCLWNIFVWVSIYHVLGIHFDACLDENYPDGTIFVKVSLEQCKEHCAVRNWCKVLAYRRLFTLCTLYREEDIISKLDEDEEMKVKSCVYITREELNLQESLTCDNLCPSYPATCDIADQKCYKDDCPRFTDPNGVVRGNMNRNQSKVNVKCDWKMLDGRSTYTTTCEAGTWSENHRCFDVSTCSNYIGALVRDSALTSSSAHKDCPPENSRLGTQQRQNTINGSAGAWCAGEVDQSPYIQVKLNAPSFVRGIATQGRDNNGQHYRQYVTQYQVLFSDNCVDFQYVMDETNEPVTFDGNNETDTVVIRMFYQMVRARCVRIFPQAHFGYVSLRFDIIGCTDWKVVFIGTPGHGGLVDVCLTTGVNTTSDLSCFYEGNERNCPQHYRNPLVDQWSKLRVAMVKYALYKKGNQVAFVIFNATDSNVTNWFQAERILNTSWTGFNKTADFIDWFQIDLADKMMIYIAIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F602</accession>
    <name>A0ABY7F602_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="126" mass="14829" checksum="C38D142F7E23B71C" modified="2025-10-08" version="1">MLSYFHLAVAIVLRNCKDMANSFLDFLQRNDNGNFTMYQREECIDLLVTWYRACLEYNTYFDKRLKVMSTLDLAGIDNVLSLKSIPIIYCSTVPIHADAKCVLEFYPGYKQSPFMHCDRTLYQRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F614</accession>
    <name>A0ABY7F614_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052787">
        <property type="entry name" value="MAVS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21446">
        <property type="entry name" value="DUF3504 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21446:SF12">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="370" mass="41688" checksum="5E0947E47AEDE823" modified="2025-10-08" version="1" fragment="single">RKDRSPYPPSTLYNLTNSIQRTLREESRLLGVKNVLCKAYVHGRPDINMLDKGDSTFMEFRKQQLDSRMKELTNRGVGIHRVRADPVTTKDENQMWENSVIGFNCAKSLSRGVFCFTSVFGFRGGAEHRNLQVEQYLLSVEPGNRILTFQACVRLFKGDLINEKLKQRFQDSLKCPLIRGVLLNILLNTYLENVPPTGPFYWKQLPGTATVSIAFSSQVVGGNTLGTFIKSMFQEAGISTKCRNIRNHSGKVTLFIRLYKDSFDEQAIMSRSGHRSTAVRDYKRTSTALRRSLIDRLQPPMAPITTATAALATYLCEPTDVVSMPLSATTMSTLFATMKSGQKNAMRNIKTETSCQKTEQNAIEICMPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9M2</accession>
    <name>A0ABY7F9M2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COLL2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="335" mass="36824" checksum="E551E2146D5D011C" modified="2025-10-08" version="1">MVTKGVGVTLGVRVTVVVRVIIGVRVTIVVRVTIGVRVTIGVRGTIRFRVTIGVRLTKGVRETIGVRVTKGVRVTIVARVTIGVRVTILIKVAIEVRNQGDNSQNNYCIHGGHRSRCDQSSRCDHISQVDHSCQGGYTSQGEHSIQDDQSSQGDQSSQGDHSIRCDHSSRCAHISQGAHWSQGDHSSRGDYRRRGEHRSQGDHSSQGDHSSHGYYSSHGDHRSKCDQSSRCDHSSQGAHRSQCDHNSQGEHSSQGDHRSQGDHSSQGEHSSQGDYRSQCYHNGQGEHSSQDDHTSQGDHSSQCEHISQGDHRSQGDQSSQYDHSNQSDHRSHGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAR7</accession>
    <name>A0ABY7FAR7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PGCA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_032480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284:SF12">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="7">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR17886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="324" mass="37846" checksum="D8BA2E8E2795919A" modified="2025-10-08" version="1">MACDEYNSIEICPDGWVRFQGSCYFLHHDPKTFTEAEHYCTQHGSHLVHVNNIFENKFLKDRLTHQRQPNDDSHAQDCVHFYVPNEFTWNDYQCSSQFPFICEKRPADIENCQCGSSGIVGCESDKFSKMEKGTYAMFCLCFAIFCLLIAFASPYWVESFEKSDNKFVKCGLWEFCFNDYSFWKDYNGKRFLGCWYIFSDQYRPLWEWLSPPWFIGCQVMISVTLLFQVVSCVVATLAYWRCLPMYLKEIIYMGTALVALLCTVLIFITLILMGIKKEDRGWMPRPDQNYLSWSYGLACISGWFMLFAAGAFAKAASDDTKERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBM3</accession>
    <name>A0ABY7FBM3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_000214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR18376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="483" mass="54790" checksum="A2247AB2C1F22638" modified="2025-10-08" version="1" fragment="single">MESYMELTQSKDNQNWYKTLIGLHITKEGLVDFVIDVMKCFHRRTFDDINRKNGRPIGTLENDQLLMTEADIRTVVRITTEGLSDKIEELRNDLHEFNSEMHCTSSISPMIQEKRSKIVDFYVAPSIETISTNRRYSCKGDHISGKGSVSTFREIFNSAKGKSRYVYVSAKAGAGKTAFCQYVAAIWCALQRNDKEEIQTFKKNNKTGHFEDICVLKEYDFLFFVSLREIRDQLCDVDDMIFQQIVTNLSGECRLKESDLTVCIEINGIKGVRNDLLTEYVTSCLNSKYGKTKDVAEFRKVMESSFLETPHQDDSIPMGCSIANICSIPVMLMHILCLWYDDVSFGKSKCETYCNMISLLIEMANMDTSVEYNGDFELIGNVTSPEKPSVFKRMEDCLKLSSLKIQNVSLDGKLDLRSCPQLTSLKLEMISLEGTLDLSACPLLNALKLKNFTIEECLEINGLPALTSIVNRTICITSINENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCH2</accession>
    <name>A0ABY7FCH2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HNRL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_000337</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd12884">
        <property type="entry name" value="SPRY_hnRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035778">
        <property type="entry name" value="SPRY_hnRNP_U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12381:SF56">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12381">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="7">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="6">
        <location>
            <begin position="343"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR18499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="731" mass="81984" checksum="B044C5D7FA68E37B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FD56</accession>
    <name>A0ABY7FD56_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DCDA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_001936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43727">
        <property type="entry name" value="DIAMINOPIMELATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43727:SF2">
        <property type="entry name" value="GROUP IV DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="4">
        <location>
            <begin position="45"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR20098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="434" mass="48211" checksum="ADC8481BC43C1456" modified="2025-10-08" version="1" fragment="single">MENFFEYTNGELFCESVSVSSIKDFLQKQSFKTVSPVFVYSKNQIVSNVNAYKLAMKKLEINAVLNYAMKANMNPTVLKIMKDLGCSVTLVSGNELALALKVGFDLRTMILNGNGKQKWEIELAVKHGCLLNIDGMFNLEQTIEVCRRLGTKARVLLRVNPNIPLDDGVHQYNRTGVHGSKFGIERRELAAMAEVVCREPCAAEAMLADIRELRKHDFPNIRVINLGGGLGIDYTKRVISVIDSVFKDDDVSLILEPGRSLIGNAVILLTEVIGVKHGHHMNYIVVDGSMTEVVRPALYGAYHHIDLAQPSHVTNADTHTNDRSHVTTSDTQYITAQHRQMTKTDGQTENPFSFTSGKENPAELGKRTPTDGRSDEVNEGWGSGRQTYEVVGPVCESGDFLGHCLMWGRTAAPWPPTTTCGPDPRRSWWTAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEB5</accession>
    <name>A0ABY7FEB5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DZIP3-like HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027897">
        <property type="entry name" value="DUF4559"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35083">
        <property type="entry name" value="RGD1565685 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35083:SF1">
        <property type="entry name" value="RGD1565685 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15112">
        <property type="entry name" value="DUF4559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="54304" checksum="26C1FADFD13E512A" modified="2025-10-08" version="1">MSYEDNDNKNWLKGSLALRITKEGLRDLVDGDSRSIQHRIHLSVIQARNLSPGTTCCQCLTENLFQCPTSGLCSHPRNNCKFHDTPVKGYRSCPSHICDDLRDEICRLHKFGGPSWKNSNADRWCVNHWEIAKCFMPLGGYKDVCSFDQTDYNGVINILINCTAFQQKLSFKVDTVTNILTQARDIGRSIRHSSDLKVTDADLNCYITTMTTLLSDPKYLSRDRKAQEAVLKLNKADTLYISNEDVHEILDEARIVVETGKHQIEQAVTEGKHIIETGKAEIEQAVTEGKHIIETGKTEIEQAVTEGKHAIETGKAEIEQTVTEGKHAIETGKAEIEHAVTEGEHIIETGKEDIAQAVTEGEHALKTGKGQLESSVIEGVKILQFEADNAVVKVSKQIHTDVLVPAENRFEEKVQARLKALKQIIQDTTDIGEREIYSRTSEGIEALDEAVFEAMRKISVSTAEREEGNIHYILVYKITFSALMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFJ8</accession>
    <name>A0ABY7FFJ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MILK2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="332" mass="35543" checksum="BD9C3CC28B8FACBF" modified="2025-10-08" version="1">MHPRPELRQFEAIVIELTTRIEAIINALTTRVEAIVTAPTTRNEAIVNALTTRVEAIVTASTTRNEAIVNALTTRVEAIVTAHTTRVQEIVTAPTTPVEAIVNALTIRVEAIAKETAHTTRVEAVVTALTTRVKAIVIAPITRVEAIVTAHTTQAEAKVTTLTTRIEAIVIAHTTRVEAIVPALTTRVEAIANAFTTRVEAIVTAHTTQIEAIVSSPTTRVEAIINARTTRVEAVVTAPTTRVEEIVTALTTRVEANVTTSTTRVEAIITAPTARVKAIVNALTTRVEAITIAPTTRVEAMVTAPTTRVEAPTTRIEAIVTALTTRVEAIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIS1</accession>
    <name>A0ABY7FIS1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="174" mass="19155" checksum="D77D89A205BFC070" modified="2025-10-08" version="1">MTSNHDNSYTPTKPANGTMEDGVQLLSFTPSNGNPSPAKRRNGPASEEEKEKLYFQDYKLNTEESKDSVYRSEFMFYLGIVSQVSNAIISFINTFFQFGGQASTRRIAIALFMMVIIFIFTVILAMIDTSASCAGVYQNSTFGQAAILPMKYINAIVLGTARPTLALLLCTTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJW7</accession>
    <name>A0ABY7FJW7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="90" mass="10234" checksum="2D9B062887EC16F8" modified="2025-10-08" version="1">MPNCVSWNQKEQKENMVLRKVKRQLKLLLIAGVLFIVVVSLKLSLDQTNIFLPFDGSVDLSFRQLLQADKSNIDPKSGLYAVRPPKSHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FK79</accession>
    <name>A0ABY7FK79_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CTNA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_016582</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001033">
        <property type="entry name" value="Alpha_catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914">
        <property type="entry name" value="ALPHA CATENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914:SF9">
        <property type="entry name" value="CATENIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00805">
        <property type="entry name" value="ALPHACATENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="429"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR22608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="991" mass="110039" checksum="908913F33B08BE6F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKN5</accession>
    <name>A0ABY7FKN5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ER6L2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_036371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057931">
        <property type="entry name" value="RHH_ERCC6L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25806">
        <property type="entry name" value="RHH_ERCC6L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="279"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="641"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="894"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1159"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1245"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1346"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="902"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="946"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1245"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1300"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1350"/>
            <end position="1365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR22702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1488" mass="168776" checksum="390D9327744E2FC0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLJ6</accession>
    <name>A0ABY7FLJ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_016018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR22044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="486" mass="55126" checksum="D5C499BC0E98D98F" modified="2025-10-08" version="1">MRVISEISDSLQKFSCRALRKEFIEKYVNFVKCPKPILRHMYFSLTGYEDSANCTMEQEIYERISKIISADDTQLLLDLRATDGSDSYYDILQVNERRKSEEMYMPLAISIETLKNEIAKRVPDGTPIPSNETIRLQFSPRNPFHNTALKYTGKFNVKFRVQTRQARVSHPDSHYAAKYFMYLKEFCVKFRENSMFLCMDDKAIIPVGEPGIPISTGVRGHNKVLAPTEGPLLVATDHDFHLGGLVPSVVFVTDIPEDPKDSFFSGNMHVRTKDKVFSPSSPLRHGAELIKLLRHTNNYSEDEANLSVPILCLYTDGGPDHRVTYETVKLSLALLFMQLDLDMIIALRTAPSHSWTNPAERCMSILNLALQHVALDRDEMESKYKKMTKNLSTLSSVRNQAKLKTGLKEAFEKSMESVVDTVNERFSQMTLKGNKIMAHKGLSDEEVLAFLDITAIGHGADSPVATLNTKRLLRKARRVKPLLLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQ51</accession>
    <name>A0ABY7FQ51_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_038012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21373" checksum="504A3F8530781566" modified="2025-10-08" version="1">MKVQGYKEVPSMLTCTSPSSGINPVGKNNPGACFPKEPQIQDALQGKQNNWKDVDVSLDDAVLIENTTRTQSDSVRWHEERHKRITASYFGAIMTRQKTVNEPFMKKTFNRPNLQNQANVLWPFNPVFQYLGASPDGIICKDAWDMTISEAVRDLKGFFLIDDGDTIRLKKLISITFRCKASLRDLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRJ4</accession>
    <name>A0ABY7FRJ4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Notch ligand N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_037148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011651">
        <property type="entry name" value="Notch_ligand_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07657">
        <property type="entry name" value="MNNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045622740" description="Notch ligand N-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Notch ligand N-terminal" evidence="6">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR23479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="165" mass="17976" checksum="96E456CE455D33C1" modified="2025-10-08" version="1" fragment="single">MMELLVFYLFIALTAGEPFVSVELRNYANPTGSDVRGACCDGTSLVGSTCLPERCDHRIKVCVSDPAEYSPVEKCGIVDGPPDQNVHNFTSGSRLQLPLVTWPTNGEAKMTVFVYDVDNDVDGSETVTLVDDMMLMFYVGTSSHNVTLTRGNTLTLSGTRHPHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FS04</accession>
    <name>A0ABY7FS04_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR23671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="444" mass="49861" checksum="5C59AF23B9A0773E" modified="2025-10-08" version="1">MTLFKGTAGAVMECTGRSPVQSGQQWNIQEEARYNPDSNEMYNPDSNEMYREKPGTTRTAMKCTERSPVQPGQQWNIQEEARYNRDSNETLSEMTRSLNINDDIVLRHNLESTASTCIDPLTQWGQVARLNWGRMPYPMGKVSFTQWGQLPRPIMGQLPRLNGDSNPASMGKVTQTQWGQVARLNGDSYPDSMGTATQTQWGQLPRLYWLPRLNGGSHPDSMGTIYLTQLPRLYGDSFQDAMLPRLNWDSYLESFGTVTQTYWGHLPRLSLDSYPDSILAVTQTQWGQFPGPNGDSCQDSMGTVTQPQLDSYPDLMGTVYLDSMGTGQIPRPNVDCYLDPMWTETHANVYCYLDSMVAVTKAQWGLLPRPNVDSYPDVMVAVTKTQWGLLPRPNVDCYPDSMVAVTKTQWGLLPRPNVDCYPDSMVAVAKAQLGLLPQPNGDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FT61</accession>
    <name>A0ABY7FT61_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CS044-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_037677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040120">
        <property type="entry name" value="C19orf44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027884">
        <property type="entry name" value="DUF4614"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22409">
        <property type="entry name" value="CHROMOSOME 19 OPEN READING FRAME 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22409:SF2">
        <property type="entry name" value="CHROMOSOME 19 OPEN READING FRAME 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15391">
        <property type="entry name" value="DUF4614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4614" evidence="2">
        <location>
            <begin position="709"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR24008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="900" mass="98243" checksum="9AF2C9DE1E99E4DC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FT97</accession>
    <name>A0ABY7FT97_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CND3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_016410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="488"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="899"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="899"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="973"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1007"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1030"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1092"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1131"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1179"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1212"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1315"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1333"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1366"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1419"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1463"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1487"/>
            <end position="1502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR22436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1780" mass="196047" checksum="5B8B1DD18F207D65" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTZ5</accession>
    <name>A0ABY7FTZ5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deoxyribonuclease TATDN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_038000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Deoxyribonuclease which catalyzes (in vitro) the decatenation of kinetoplast DNA, which are circular DNA catenated to each other, producing linear DNA molecules. Plays an important role in chromosomal segregation and cell cycle progression during eye development probably via its DNA decatenation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR24331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="225" mass="25858" checksum="534192DE9E592BAC" modified="2025-10-08" version="1">MAAPMRRYPVFRGVYRGKTHHEDDFLDVLKRASDVGVEKIMVTAGCMEDVKEATELVKSHDHLYTTIGCHPTRCSEFEKSGDPDGYMNQLLDIAAQNKGKVVAVGEFGLDYDRLQFCPKQTQLKYFEKQFELVEQLQLPLFLHSRNAASDFSDIIRRHRDKFRGGVFPSKKKEKWEKGNFVKSRNEPATIIQVLEVLAGARNENIEDLARVIHDNTQKLFFPSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUA7</accession>
    <name>A0ABY7FUA7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPA5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_037975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR24306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="83" mass="9599" checksum="21063F074683174A" modified="2025-10-08" version="1" fragment="single">MYYPVGVSTISSSKPRFNDGHLRFMVLADWGGLSFHPFTSPVQKAVRDQMTSYARENKPEFLLVLGDNFYLYGVNNVDDRRFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUJ0</accession>
    <name>A0ABY7FUJ0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_038503</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="118"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="230"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="402"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR24834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="498" mass="58013" checksum="CFF79AD7AC6F2E8F" modified="2025-10-08" version="1">MDERHPDYINASYIYGYNKTRAFIASQGPTDDMLMDFWRMVWYLDCGKIMKCVQYWPDEGCKEYEDFLITNRGTEYFSDFIIRKLSIQKTHGEERKLIHFHFTAWPDKSVPKYSSSLVHFRHKVETTIVNENGPVIVHCSAGIGRTGTFIALNVLSEQAATEGYVDPVGCVSNLREQRVNMVQTAEQYIFLHMTLLETLMLSTSALPSSRFLGAYEELLAFDKTQRTRKIDVEFSRMEKMSPVADVCQYVRAKELRNRNKNRYSNILPDADHMPYLTPSGKRSEPDYINAVFLPGYKKKRAFIVTQTPLEATKTDFWRLVVEHDVHTIVMMNNKSEMKEDEIYWPENEEKYEIMTITKTGLECEKGLRKMTFDLKRFGQTRKLQQIQFEGWPDDSALPSSPKDVINLLDAVQFWQQQSGNNPVLVHCMNGADRSGLFCVASTVLERMKIEQDVAIAQVIKEMRNYREQIIPSVDQFQFVHEVVKEYILQNETYSNFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUV7</accession>
    <name>A0ABY7FUV7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_011631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR25927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="474" mass="53404" checksum="979278C3C9E775F4" modified="2025-10-08" version="1">MDTYKKSIHSAQLLEAQQKQAIQDYKFNLFKRIEQSERKLIDKIEEIKTKDETRLTTMKAKIPGVLSSINSIKSTLHSKNVNSSQLYVEAKRAKQEVAKLRLALDRMRIENTIQKYRFKGDILSESMLATNNVLGSIKEDDNDDDALTDTTDHDLITDSKDMVEKVMVGRAKEQFTEDLTDCDDAKDFCGQLLPFVKKLPGINASIPSDWSFCCLNSLQVLPNDRLLATDQENACIKLFNTKTNLFISHLKLAGKPSDSCIVPSHRVAVTLPMERQIHIVDTQEELILVDRFTVNGSCRGIAYYDDRFIVSYTELPRVEILDVNGETLEIVLNASLHSQIFQYPNHLRVETGHKQSFIYVSDQKANMIIKLNMSLQVINTFSGESLRAQGNICGAGENMLLVCATKNNGIVALETKSGNMKTIFGQNDEIAKPIATCVCREHNRIFISNDERGKSDIILVFEGKLKKSTECSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVG7</accession>
    <name>A0ABY7FVG7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">KIN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_036840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="388"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="871"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="967"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1006"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1112"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1183"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1239"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="578"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="884"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="967"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1046"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1062"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1112"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1134"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1252"/>
            <end position="1271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR23171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1288" mass="143660" checksum="B1C4FF570413EC96" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVI0</accession>
    <name>A0ABY7FVI0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="18">VLDLR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MAR_036855</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">MELC-2E11</strain>
            <tissue evidence="18">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045386833" evidence="16">
        <location>
            <begin position="23"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="795"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="372"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="13">
        <location>
            <begin position="509"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="13">
        <location>
            <begin position="552"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="13">
        <location>
            <begin position="603"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="740"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="747"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="759"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WAR23186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="866" mass="95894" checksum="6FBEE15A705F237B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVU3</accession>
    <name>A0ABY7FVU3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR25284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="180" mass="21174" checksum="EA50A14FAE75245D" modified="2025-10-08" version="1" fragment="single">MNIHQYLFREKSAFLIKSHTGIKNYQIYTDALEVLITNTVLTIKNAKRRFRRLHRKSVNTYLTTLDMELDNAAELDQKRFWKLIRRRRCNLNRLGAGINFNGSVVRDRLQLTQEWGHYFEKLYTPINKTGFDGEWHEYVSAEVKQKFRSLHSDPNATVCPRQIRKAILEYPSGKASGPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWF6</accession>
    <name>A0ABY7FWF6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR25171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="198" mass="21527" checksum="2A2D825C20587135" modified="2025-10-08" version="1">MSPLVKNLQWKGIFVCQKIALRDREIRMYFSQSGSLSKLHADANVDWQRRRLQFYDYIKTPSCFAVSRPLTMKKDGIQTRNRKMSTKSKKNKKLAAMSDLLKGGPLDKFSGFNPMNHAMHAPMPTYMTGGSSFGSSYLSHGGHHMQGAGATMGGFGNSFPTSSFASSFSNIPNGGYSSGLSSGLNLSTSTNMVGAAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWM6</accession>
    <name>A0ABY7FWM6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_011368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR25664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="234" mass="26792" checksum="80ECA42BA4AC2E08" modified="2025-10-08" version="1">MAKSYMTLKQNIERENWIETCFGLDFVRKALVPFVISKLKERHTLVLRSAGTNNACQGCHLDTLLLKHSNPSKKQCSLNRRNCLCTSKSSGRKSCPTNFCCSMYNAIIDDHFYGQPEWKNTEMQQWAGDYWAVGKCYININSYKECGSAEEVDSSGLLHIVLNNKYLRSIVDGSGSINDFITLMDHDHSISTQAEVNSLRHNIEILTNENQHIKQHLLDKAIETQNKRLQYLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FX48</accession>
    <name>A0ABY7FX48_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="180" mass="21156" checksum="60929CCBA90D09F4" modified="2025-10-08" version="1">MRFRNNLKENPELWDKYKKLEKKRKGIERRNRANAERHRKGKESQRRYKMRLKEKGTQVKNNVKTVLTRSERGKKRNYWREKQAKCRAGKSAQKKGRIKEHDRNYRIATETNKKKNLSSGSTNTGHSSMSKSALKKASSRIKLPKHPKKFGECFNYIVQWATPPKRAALSNKEIICSPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXF0</accession>
    <name>A0ABY7FXF0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DHR11-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_037500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR23831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="166" mass="18334" checksum="18876B7495D6A315" modified="2025-10-08" version="1" fragment="single">MERWEGRDALVTGASSGFGEDIAKRLTECGMKVIDCARNIEKVQALADALKDAKGSLTAIKCDVSKEEDVLAMFEQIKKEYGGVDVCVNNVNVIGLMTCSREAYKSMKERGVDDGHIILMGSMAAHRVFPDAPYMHCYSATKYSVKAITEGMRNELYDAKTHIRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1T2</accession>
    <name>A0ABY7G1T2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_012888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR27184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046211638" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="197"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR27184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="261" mass="28672" checksum="076FDF06EED08D61" modified="2025-10-08" version="1">MIEYITSLYALVAATLVIAGQDELVKCTPGEYHIIGKADCTGYYLCVFGNPVEMPPCPPGSVFSSSSNVCVSKGSIYDDCKKTTDGSGSHITESPDQVPLSPEERCNMFGGVFPHPTECQAFYNCSVRLPSCEGKRDGINVHPVRLWTPFYAVCYKERTVKQDRCQADVDGRAQLFHPEKNECVSLDMIPREHGGMMPECGTKVDGFYLDDFGRCDRYVHCQGGKYIGTIKCAVGEAFDDSRGGCVPEEKACGPCGKLEHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2X5</accession>
    <name>A0ABY7G2X5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="479" mass="54782" checksum="A36E0D46AB7E39D5" modified="2025-10-08" version="1" fragment="single">VNLKPLDEEEIVGIKTKSKDCKYPQLRPFDGSKKNVDPVEMIVRCPDAFIDANVTTKCEENYILNSNSGSYALNLLRPVSSKMNNMTFKNYFCAKCHDFDDNRFTQWETTLTCDSMASEIPNIQSFRDIYPQLAIHDHCNVAFRPPLDFYPQVCEYGISRCNQTGKWRVYDDMLEKACLSYTSTYKFQYKNVHCALCNGFEREDVEPFCGSNAQMDPVSSQFSFLALLDFTGLEDGEDQFESDCSSGMIYDIFQRKCREIFCPKSYFLDGNECRPVINGESRYTFGPFSVISMDITFHLKPLGSLGEDSLSTFELSSDTNVARILYNKLMIPPLGQHRQARVEICNLRSFLKMTKSMNETIEEIRQTNESALLSNIDFIGIHVQLKVFDFTDLTSLIDHTASVIRGTELMFQDLHLIYQAFDDLTFLDYHTTLGFDFKTFLRVIDLNASAITTTRLLGSFDGADGLGIMPLFNEEDTWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G338</accession>
    <name>A0ABY7G338_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RHBL4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_013436</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF1">
        <property type="entry name" value="RHOMBOID PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="10">
        <location>
            <begin position="118"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="197"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR27732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="272" mass="30910" checksum="B14DA012F561616D" modified="2025-10-08" version="1">MFRGGRRRGQNFGILLLGMQMMNFGFDKIPPVTLISIIGQVAIFLGFGDLDRWFGSVRDVCISTHLVVSQRQWSRLLLGTLVHASDMHLQHAGEEVPESLLCLHVGCVHISIQRPVSVIFALKVLTVHYSPRGLHYALGFIPVPSRYIYWLELGLIQIIYPNASFTGHLAGILVGVLYIKGPLKMIMDGFMSPEPSYTYTQGTTNRQPTGRGYTTGRGSERMYEDYTGGLSEEEQIRRATRQSQQENFRPNGEERLYPDLDDLRRRRADRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G346</accession>
    <name>A0ABY7G346_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">XPC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_011425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="549"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="590"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="722"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR25721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="794" mass="90381" checksum="C1D207FEEE4CE9F5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4Z4</accession>
    <name>A0ABY7G4Z4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="277" mass="31217" checksum="FC55EF8DB2215BFC" modified="2025-10-08" version="1">MIIGGNIATDRESDLAITVLSNIQYVSRSMFVFVFAIVTYLGISRTDMSAGGEEVHLMFPLGTTLDRPGHKHTIQDKHAQEHWLEEHQCNNLKGKLSSVTLAYSRKGLQICPTQSTTSIQEYMYNNPMSYPGILQERATDLPNTEPHKHTGINITMAARILGSVNDSMTGTQPMDQSKQSHQGLSISHILMEYRQSRIYQSETYPQNGSIDKGVWVIKHLKDRKNSMNTIAHRRSAQSTIPDTCNSTQDGEHEHYGTQEICTVYYTGHLQLYTGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G573</accession>
    <name>A0ABY7G573_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZNF45-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_002878</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR29310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="243" mass="27427" checksum="3DF87EBA717A16C3" modified="2025-10-08" version="1">MYMFASNTYTGDKTYWQHSQRVNKRVDSRAAQSRAPSRDIEATSYALLTYTELGKLSEGRKVVNWLVSQRNPSGGFASTQVPSNIPSIDIYAAGEGVVVVDFNRWTGQTPSGMLLMEVERPTACEKFARVRGCQNGSLGPCGEKPSMPCDDWRWSIHMELHTGEEPYKCEIYMDMHTPADKPRKVNGAKFHRKSDLKGHMKIKSGKKPYKCEICDAAFSKKSNLQPHIRGHTGEKPYKCEREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G667</accession>
    <name>A0ABY7G667_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOT12-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_014538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="351" mass="38556" checksum="BAC9227EAF1EBF78" modified="2025-10-08" version="1">MKLNNETTPRYGDSKLHADDAISGTAKVPKVPDGGWGWVVCAASFLVHMLIDGSTALIGSLCQGVLTLIGPVVSILVRKFGCRTVVISGALVASASQVVSISAPNMQFLFFSLGVMTGWSFAVNSTKFRIRTNSSSIDRIGVSGTGIETFIFSPETSFLVQKYAWQGAILLHAGLLLNCIVCGLVFLPHTLLEPEHEQKNNSFEFETGTANTGCSSREHLERVQFCSTGFADSTEEPTEEKICDNPLKKSTDVRIACPEMRSLSEQNITHDISTNDNIYTITQTSSELMQNLKGKYTFTCSNFISGDITSLREHFDCAIFKLMSFNLFMVSSFFLRSRILCSLHIPSRHCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G701</accession>
    <name>A0ABY7G701_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="113" mass="13048" checksum="B1237FE387D83DBD" modified="2025-10-08" version="1">MAVRIRTGTVFCLIHLSYYSTIRPGTKVGDPVVTNIRLLQYNTNGEIQFKLLFHDEFSNLPRRARRSDVVNQDPTPLHCGPLAIKRSKFQHLMELKSVVPADYHPFFDNLNHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G827</accession>
    <name>A0ABY7G827_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAS1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_003137</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045504849" evidence="2">
        <location>
            <begin position="22"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="171"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="643"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="605"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR29569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="804" mass="90743" checksum="5219F633E7C06709" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAD2</accession>
    <name>A0ABY7GAD2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MTF2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_033622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd15503">
        <property type="entry name" value="PHD2_MTF2_PHF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR31080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="832" mass="94671" checksum="3191275606562714" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAU3</accession>
    <name>A0ABY7GAU3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRAM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="247" mass="26376" checksum="C0DE148F8CE630FB" modified="2025-10-08" version="1">MANLTKMDNLTAMDKMTAMDNLTAMDNQTAMDNQTAMDNLTAMANLTKMDNQTAMDNLTAMANLTKMDNLTAMDKMTAMDNHTAMDNLTAMDNQTAMDNLTAMANQTAMDNQTAMANQTAMANQTAMVNLTAMANLTAMANQTAMANQTAMVNLTAMANLPAMANQTAMVNQTAMDNLTAIANQTAMDNLTAMDNLTVMANQTAMDNQTAMANQTAMDNQTAIDNQNAIDSLTTADNHTAIDILTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBX3</accession>
    <name>A0ABY7GBX3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-Fucosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_034435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">Golgi stack membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 11 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd11301">
        <property type="entry name" value="Fut1_Fut2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927">
        <property type="entry name" value="GALACTOSIDE 2-L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927:SF9">
        <property type="entry name" value="L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR31893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="385" mass="44504" checksum="004DBB43A11CEE66" modified="2025-10-08" version="1">MAMKVITRTLNKGEFLKHMKVQVKKFTEHVHISNDWRCTIFKTIVVEEEERKRPTVEREVPQKLIAEEPYVLAVGTFVVAMYGTKVYIGKILGNDEDVRKLLQLPKHEDRIWIDRQNIICSVLEPSPTGKSRRMYKLSESDLKNIERGAGNVMFKIAALIGVAKRHGFLPRTTFDNHRIFKWFELPPIYYKFPATNSILVKEERHEYQTVVETLDTSRNWTLGGFRQSWRYFANARNEVRQMFTCCERLRTCQKRRHAPGGRHKTRESPNGSGVSQKTSLEIGLTTEQSTLIISDDIKWCKISTSGPDVFYSPFQTDVLDFALMVCCDHVIVTMGTFGWWGAWLSGGITVYYSAWPTKGSSLDRDLNTSDYFPDNWIMAKENLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GD98</accession>
    <name>A0ABY7GD98_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="102" mass="11714" checksum="3A7A192C408A3B92" modified="2025-10-08" version="1">MRAAQRGQHNEGKTLNDLSTTRFHKFPVLIVEGVSCSPTYIRTKMAVPNGHFKNVDQEIELKLQNVDPEIKLKLQNIVFTQDLQLCKKILMKAPREDLILDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GF17</accession>
    <name>A0ABY7GF17_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="116" mass="13033" checksum="546CC9B6370FD270" modified="2025-10-08" version="1">MSCEVSVLSANQLHPLIIAFYLENKEVIDAFLLSSLDAAQTLVQQFMPIFTQFFSILLETGSNLLGNFNIVLGITKVPLQVIFGFAQANPVTFTVALLALPVIWMCRHRIRSYLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DC35</accession>
    <name>A0ABY7DC35_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006396</name>
        <name evidence="3" type="ORF">MAR_006397</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ93925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ93926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="156" mass="17557" checksum="A1C299FE460C5D38" modified="2025-10-08" version="1">MSGGNSYGTPTTPRNTNPTCTHMSWSHGTSPRRRGQLRGERLGEVERNNRKHNDRANSEKKTSSVRRRTTSCSTVHPVNFVEPKVLFALYGGVTRIIGEKLHRLGLCNTDSDDSDSSSTDEVSFKRRFTEDPQSKDIFKDYEVSSTFPNLSFDAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCU6</accession>
    <name>A0ABY7DCU6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPMD8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022041">
        <property type="entry name" value="Methyltransf_FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47705">
        <property type="entry name" value="AGAP000321-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47705:SF1">
        <property type="entry name" value="PNP_UDP_1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12248">
        <property type="entry name" value="Methyltransf_FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Farnesoic acid O-methyl transferase" evidence="1">
        <location>
            <begin position="142"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="696" mass="79025" checksum="A1A82BE2E3354D4B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DE55</accession>
    <name>A0ABY7DE55_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_028249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ95559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="76" mass="8589" checksum="B7840F4170CE8BC2" modified="2025-10-08" version="1">MTSSRDLLEQTSAETHILCVDKCSKDDNVDASLRCNAVRYNALDKSCELVLSRGCEAPAAALQAHWTIYRLYFMFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DET9</accession>
    <name>A0ABY7DET9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PTN4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_007607</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06706">
        <property type="entry name" value="PDZ_PTPN3-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14541">
        <property type="entry name" value="PTPc-N3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706:SF4">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="692"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="857"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="1030"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ95136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1142" mass="128961" checksum="EAFED7B594BC3697" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DF20</accession>
    <name>A0ABY7DF20_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045189938" evidence="1">
        <location>
            <begin position="20"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="139" mass="15516" checksum="7327ECF181DB86B8" modified="2025-10-08" version="1">MKGYIFLFLVATAFCQATAQGTDGLTAKAAEETDEETDIDIKDENGNLVTQAEIFSDVKNDTSECYKEKPLTFEIPSSVWAFCEGREMTVLEAIECADKQGQERNFIDEIRGVDNRYIYDRAQNNLVLSVDVTVLLASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGE7</accession>
    <name>A0ABY7DGE7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein tweety homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_029454</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Probable chloride channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the tweety family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006990">
        <property type="entry name" value="Tweety"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424:SF8">
        <property type="entry name" value="PROTEIN TWEETY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424">
        <property type="entry name" value="TWEETY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04906">
        <property type="entry name" value="Tweety"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0868">Chloride</keyword>
    <keyword evidence="9 13" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045386801" description="Protein tweety homolog" evidence="15">
        <location>
            <begin position="17"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAQ96764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="476" mass="51906" checksum="AFC267EF299C44E8" modified="2025-10-08" version="1">MLLVPTLGCVVLGALADAGYVVSTVKVGRRDACDIFAGRERLWSGSFDRFMDAADKKAAINEALAACSRKLPANNGSVAVGFFGNEEGNKGMQSTMDALQGTNDTLAGSLDTLSVLDEVSGNITSLWVEALKEVFKKRLTNATLEKEVSRMADEIKNQSSIMGGHDHPSLLAAPGPACLHTRQLEEVQILAHMALSDFCVDPDSFVIGQLEKKLSPDDCAIDDALTYIDKANKTLDEALLKTKKYNISQFLAGPVKELRGGLTSAKVNVVSLSDTVYCGQIHTHYVTALRGMCNRALVGMSLILLMLPALGLCLILLQCCAPRIWFLLAVRKEYKIVDIKDPFLPRPPPYHTYGTIGGERTPLQEQPVMEDRDVLSRPHRVDSDDSPPPAVSTSTLELSDHTHGDCMKRCVFILTADNKYASPVLHGAIMNTTERLHGSDEITNLSTAGVRIIFHNFTTEEYNEDSTTGCHCFGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGR5</accession>
    <name>A0ABY7DGR5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="95" mass="10919" checksum="74A2028696B6768D" modified="2025-10-08" version="1" fragment="single">MARGERFVTTISRCRTGMSPADSWDLRPCLKCLVGVTLVQEQVRYFTMTFTVGEQKIALTNATEHMTRRRLTVSTRRISESDVRPQQSRQPKASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHN3</accession>
    <name>A0ABY7DHN3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SYP2L-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_029181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the synaptopodin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051976">
        <property type="entry name" value="Synaptopodin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24217:SF0">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24217">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="12"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="770"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="871"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="787"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ96491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="891" mass="99053" checksum="351A1B2FAA96FAE6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHW0</accession>
    <name>A0ABY7DHW0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_029962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ97272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="114" mass="13722" checksum="60E0879212DEA444" modified="2025-10-08" version="1" fragment="single">YGRNLLRTRTTNKALGRHFIRTRTTDTVLGLHFIRTRTTNTVLEHHSIRTRTTHINHEYSITAPFHMCQNHKYNIRAPFHTHQNHTYNKRAPFHTHRNHKYSIWAQSPSHQNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJ76</accession>
    <name>A0ABY7DJ76_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_029658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46954">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46954:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ96968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1096" mass="123229" checksum="7173A188E8660573" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLS7</accession>
    <name>A0ABY7DLS7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ97474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="135" mass="15950" checksum="FA000E35910D4075" modified="2025-10-08" version="1">MLMRYFQSNFKSNACQGIVCHNILDEFRLDRSVGIDWQLLFKHPKNEVGETIKDNKAKIVNKAYCQQSIRYVNTDKMKTIKEKHQTLHNVEDLQVPKIVHFLWDQLKNQTKAIDVTREKFKPVHNTFDESNSSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DN59</accession>
    <name>A0ABY7DN59_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PGRC2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_023505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF106">
        <property type="entry name" value="IP06960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="68"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ99132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="195" mass="21984" checksum="0DC2835785710508" modified="2025-10-08" version="1">MADQSESSAGSEGNFAVNFFKELLSSPLNLALLGLCGFLLYKIVIGQRKPDAARPKEPELSKMKKQDMTLEQLREYDGKGPEGRILLAANGKIFDVTRGKRFYGPGGPYGLFAGRNASRALATFSMSEDVFRNEYDDLSDLSSMQMESVREWEMQFTEKYDYVGRLLKPGEQPREYSDTEDEQSEDKSESEKKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNG1</accession>
    <name>A0ABY7DNG1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd10229">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="928" mass="104702" checksum="E5895C3F44E3158A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNJ6</accession>
    <name>A0ABY7DNJ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="97" mass="12418" checksum="FDC63463C914E2D5" modified="2025-10-08" version="1">MCSYNHNNHNAHYNYTNNNFNYTNYNNHSTNNNYHYTNYNYHFTHYNNHNAHYNYTNYHYHYTNYNYHYTINNNHHYTHNNYLNTNYHYINKKDQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DP00</accession>
    <name>A0ABY7DP00_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LRR70-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_022689</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617:SF169">
        <property type="entry name" value="LRRCT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ98316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="195" mass="22456" checksum="6A6C71565D196829" modified="2025-10-08" version="1" fragment="single">MFQLDLEGSFIKNNTFIIMFFTACLYARFKRMQPRQVSKYTCLSFPALKTLKIALNQIKDIEEVFIPMNHSLENIDMSFNRLQSIPYALTKFHLMVYLVLNFNNIMSVQIDVLKNFTSLIWLKLNSNGILKISDDAFQNNINLGANNLTKIPSSVKPLSKLKYLDLSFNDIKCSCSNFHLLKGWTDSNDLSLSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DP92</accession>
    <name>A0ABY7DP92_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="142" mass="15734" checksum="BA8A43738978B5AB" modified="2025-10-08" version="1">MPGQRERSELLDEDGASETNSRKAHTVPIDSDSDDSDDRFLKSVFPISNKAENILAVPSIDSIVGNLLLKKYGQKAVKSQSLCSQPMKDLEKIAYQGQHAARMGTVINVYMQQALRNLLSKLTDKQCNIDSAIVCGTFCHKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPI8</accession>
    <name>A0ABY7DPI8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CAH10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_023987</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF208">
        <property type="entry name" value="CARBONIC ANHYDRASE XA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045504812" evidence="4">
        <location>
            <begin position="21"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="5">
        <location>
            <begin position="30"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ99614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="269" mass="30574" checksum="65E099D649E4025D" modified="2025-10-08" version="1">MDSNIIVLLTIFFFLESVLSYCPAADHWSGWWGYDGYASGPSSWGDHNEDWVICKTGKNQSPIDIKPQALLYDPQLQPFKLETASVSGTFRNNKRDLTLLVNNSNPAVNFTAGPLSYTYRLYQIKLHFGRENVSGSEHHIDGKAFAGEIQFMAYNSDLYANHSVAQVSPRGVAILAVFISHLPVDKLLPKSLDHYMTYAGSLTQPSCRETVTWIILNKPMYISSKQLTDLRRIPYQEWRDSNARPIMPLNRRTIRTNINFGKRLIPTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPK9</accession>
    <name>A0ABY7DPK9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DOS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_023015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046355">
        <property type="entry name" value="Gab1-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45960">
        <property type="entry name" value="GRB2-ASSOCIATED-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45960:SF2">
        <property type="entry name" value="PROTEIN DAUGHTER OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ98642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="612" mass="68042" checksum="5E6DA280EBC159DC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPW5</accession>
    <name>A0ABY7DPW5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ98918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="41601" checksum="F6B2B3125F11A64F" modified="2025-10-08" version="1">MSCQERFNGIIYEGPEGGVPIYLYYHDEHFDVITKMTGFLNRKRRVCNNPCVYCHQLHTDETEYWRFCDKCNRYFKNGICFQMHLKKSSEDVKNTCEIYFKCKDCDQTINLKRHKKAHVCHEKTTNVTCSQLREKRKLTKQPARMNDDRLECDQGFVEGKTNKCNNCRKSWCGSNENRPNLCVAHRVCDVCLHSPVTSESSCKTCGKNERIFQGLETTEGFCKWLFSEENVGATVICHIFKGYDSYPILQYLHNNSILPDVITTGSKYMSVKVSLCNIRMIDSLNCIPMPLADMPVFLAILSKQKVTFLICSIENQSAILPHLPDLQFYAPDSMKPEARRTFLQWHEINKTKPFDLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DR83</accession>
    <name>A0ABY7DR83_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_023218</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF42">
        <property type="entry name" value="PROTOCADHERIN FAT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="22"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ98845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="146" mass="16927" checksum="B23D0CB16F983387" modified="2025-10-08" version="1" fragment="single">MLYTSVSSWAIIGRFQGHEKGFPILLEHLGSSTIMTSQVLDRETATHYWLTVYAQDHGLVPLHTRLEVYIEVRDVNDHIPLPYQPVYYGSVRENDNNGFVTQVQAFDLDRNLNQSLHYEITRYDPLHFFQIDPKTGKRLCSSRTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSS6</accession>
    <name>A0ABY7DSS6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Snurportin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA U transporter 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_024284</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the snurportin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd09232">
        <property type="entry name" value="Snurportin-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017336">
        <property type="entry name" value="Snurportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024721">
        <property type="entry name" value="Snurportin-1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047857">
        <property type="entry name" value="Snurportin1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13403:SF6">
        <property type="entry name" value="SNURPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13403">
        <property type="entry name" value="SNURPORTIN1 RNUT1 PROTEIN RNA, U TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11538">
        <property type="entry name" value="Snurportin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21974">
        <property type="entry name" value="SPN1_m3Gcap_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="13">
        <location>
            <begin position="62"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="359"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAQ99911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="394" mass="46202" checksum="C48A07373D33BD49" modified="2025-10-08" version="1">MLTVDSRVMFSPQSACPLTNEDQIRTLPNEKFGREKLKSKDIFRFSPRNKDMDELAESLATSFSVSSDPNSTDAPHPRFSEYKKKTSNSDQEARRKNILEQQKERRFDYAYHARRLLEDDWQDSDDLEDDEGDAMELMLSEWLVEVPQNFEKEWMMGTTTAYGRNGYRVNSFPSHLPGGNRRQKDNYKDNAILDCIYHEVEKTFYVLDIMNWKNHPVYDSDTDFRFFWMMSKLQEVPELGEISKLNPYKFIPLQYHDCQKETLTKVFESATQQFDGCLFYHRQAHYTFGRSPLVVWLKPYMVSEMLGLEVPPAMMEQKPANYTTYQQHLTQVKETRERQEKEKTDRLVEKKARRMADRAHKFKMDVSGGGDGQQVQAQGENMDHTNMKTAGDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DT20</accession>
    <name>A0ABY7DT20_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">PC11X-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_024416</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046487129" evidence="12">
        <location>
            <begin position="27"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="787"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="25"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="135"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="246"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="361"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="479"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="567"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="688"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="826"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="943"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1002"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1088"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="829"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="840"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1003"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1030"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR00044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1138" mass="126263" checksum="3E288789424B48B7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DT30</accession>
    <name>A0ABY7DT30_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MITD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_024142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd02685">
        <property type="entry name" value="MIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.30">
        <property type="entry name" value="MITD, C-terminal phospholipase D-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052817">
        <property type="entry name" value="MIT_domain_contain_protein1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032341">
        <property type="entry name" value="MITD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038113">
        <property type="entry name" value="MITD1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21222">
        <property type="entry name" value="MIT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21222:SF1">
        <property type="entry name" value="MIT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16565">
        <property type="entry name" value="MIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="2">
        <location>
            <begin position="43"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ99769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="289" mass="33294" checksum="5731CFBCD8A9DC53" modified="2025-10-08" version="1">MNTKCQYKVVHPVKICLDRPLGSDYPGLIPDPVILEDVVKDKMSGVLASAGSVLTRAVELDKTCRYMEAVVCYQEGLQLMMDVLKIAPADRKEGYRAKIKEYMARAEELKKKVEEEKEAGKYHEQLRIENNSTGHSYERLFGRFLDEQLTLVTVEDPYIRSTHQLYNLLRFCEMVVKSQAKVKTIKLITGQDDHPDQISMQTKRLQELAASLLSYNVTLEWEFSNTLHDREIRFNNGWIIKIGRGLDMYKATQGKFVIGFCDFDLRKCHETTIDIFHQKHLNTAHSVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVK7</accession>
    <name>A0ABY7DVK7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA-binding protein 8A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_025098</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RBM8A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="73"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR00726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="167" mass="18802" checksum="D3F59294B7D6AE0D" modified="2025-10-08" version="1">MADVLDLEGEGEFEIDEVGDEGLQKLKEKAKKRKGRGFGSEGTTRSGIEDKDYEGMEVDTDGGPGPQRSVEGWILFVTGVHEEAQEDNLYDAFSEYGEIKNLHLNLDRRTGFLKGYSLIEYETFKEAQTAIDSLNGSDILGQKISVDWCFVQGARKTKGRREDKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVY4</accession>
    <name>A0ABY7DVY4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="143" mass="15567" checksum="F8F82D8D65A48FAC" modified="2025-10-08" version="1">MFGPAAGRLNRRLDAALSEYLKKTTPDADIMHKRVVIQFPLSVLQLQDCPDTTKGLCSHLGQSHAISARRQPFNYFQQFQMILLAFANSLLGMSVRGRGLRSGQAAATVVHAATADDTSSARVQTQVPADRHQASSPPVLQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZG0</accession>
    <name>A0ABY7DZG0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NWD2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052752">
        <property type="entry name" value="NACHT-WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871">
        <property type="entry name" value="BETA TRANSDUCIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871:SF43">
        <property type="entry name" value="SI:CH211-212K18.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="887" mass="100454" checksum="3878EAAED0F319E1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0Z5</accession>
    <name>A0ABY7E0Z5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CC157-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_009060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029681">
        <property type="entry name" value="CCDC157"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43696">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43696:SF9">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="648"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR02502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="779" mass="88089" checksum="358154C915E321E4" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2X3</accession>
    <name>A0ABY7E2X3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046998271" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="54" mass="6252" checksum="CF995AC16AB50C7E" modified="2025-10-08" version="1">MQSFISYLSKSFNLILVVMLNTYQKVDSDEKVRIGQTIDRIIFADNAVPFNHQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4L4</accession>
    <name>A0ABY7E4L4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_020326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR04957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="301" mass="33278" checksum="80A9AE5166FDD5CA" modified="2025-10-08" version="1">MSKPPSKFVDDQHFCVLTQFALASTAVVLSALSVNVPHDGSSDIPYFICGFILAALHALMIILRIVVLTSLSRKGEPTKKKILDTFLEVRCVDLLWKVFCILGFAWGITGVVLCALGGVSCDKEKNKEGEEFSGANATSSCYYDIYKEKGGQYKGLAIGLLVVHVFSSVWFFFSFFTYSHYAKELVDPKPQPQPKPAANANPAPKPKQPAGSDSTKKAELEQLSAKKADLEQLEKRLNDREQAIQQRELGLNERENALWTVHLNNIQGGPPPPPSYEQLAMVEESTTASRSIVEQEKRNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E504</accession>
    <name>A0ABY7E504_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR04030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="239" mass="27146" checksum="DC296CA8BFD726CF" modified="2025-10-08" version="1">MAHVAPGRCVLLHRLNTLTVYNMYNIPIQYNIPIQNNFKQSTTCTIYQYSTTSSSLQHVRYTNTVQYTKTEQLQAVYNITTSSSLQHVQYTNTVQLQAVYNMYNILIQYNFKQSTTCKIYQYSTTSSSLQHKSKDHSAHFNVVFTLESGIETKEPIIDSPSHTVQAGVRGVDSKSILQASDHCTLLPVSLAESLETCEYWRMVGDDHVCLQCQRLIKDRGSEVVSEEDGVDCVGRGWLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E529</accession>
    <name>A0ABY7E529_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_010204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013659">
        <property type="entry name" value="A_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08451">
        <property type="entry name" value="A_deaminase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047391098" evidence="1">
        <location>
            <begin position="21"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine/AMP deaminase N-terminal" evidence="2">
        <location>
            <begin position="45"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR03646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="278" mass="31563" checksum="7FE3E7A3C2633479" modified="2025-10-08" version="1">MEYVNFILCVAIVIMARSFGVSFKTVSGGPIFVSEMSMDSVYKGSKFSNDKDYMQKRQLFIDTEAQERVGGEIVMNLDEKALNNRILAMKKKEYDAAHYQGGSFAPQINFLQSKPLYEKSDIFKLIQKMPKGGALHLHDVSITDVNWLVGNVTYRDHCYMCNDVNANDSIVFHFFQNPPSNPGCPWKLVNDVRAKSNNVTAFDQMLLESMVMTPELADADINVIWKAFTGALTRADGLISYRSVFRDYFYEALTEFQADNVQYIELRAVFPGVINTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5W6</accession>
    <name>A0ABY7E5W6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MRM3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051259">
        <property type="entry name" value="rRNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191:SF2">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="569" mass="64341" checksum="266F8B4AEE9162AB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8Y9</accession>
    <name>A0ABY7E8Y9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SEM5A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_020233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF79">
        <property type="entry name" value="SEMAPHORIN 5C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045779704" evidence="6">
        <location>
            <begin position="27"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="855"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="7">
        <location>
            <begin position="39"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="894"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR04864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1228" mass="136815" checksum="7AE5AE99A469BB16" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAK5</accession>
    <name>A0ABY7EAK5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sortilin-related receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Low-density lipoprotein receptor relative with 11 ligand-binding repeats</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Sorting protein-related receptor containing LDLR class A repeats</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">MAR_020818</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">MELC-2E11</strain>
            <tissue evidence="29">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endosome</location>
            <location evidence="7">Multivesicular body membrane</location>
            <topology evidence="7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus</location>
            <location evidence="5">trans-Golgi network membrane</location>
            <topology evidence="5">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Recycling endosome membrane</location>
            <topology evidence="6">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the VPS10-related sortilin family. SORL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="22" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="19 25" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0967">Endosome</keyword>
    <keyword evidence="21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0675">Receptor</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="27" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="27">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046251020" description="Sortilin-related receptor" evidence="27">
        <location>
            <begin position="20"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="26">
        <location>
            <begin position="851"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="1519"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="1713"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="1804"/>
            <end position="1904"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="1908"/>
            <end position="2004"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1093"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1100"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1112"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1132"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1139"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1174"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1181"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1193"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1235"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1275"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1322"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1342"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1349"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1361"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1407"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1448"/>
            <end position="1463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00007041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00029896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00032450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="WAR05449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2044" mass="229386" checksum="64248F711BEE9A90" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EC50</accession>
    <name>A0ABY7EC50_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7 9">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_021662</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7 9"/>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="464"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR06293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="506" mass="55985" checksum="D87C6861BF91D640" modified="2025-10-08" version="1">MLITRSLRLCVLKTPSFILTPSKTVCSKVPFCSMMANEEMTTEMEGLSTKFNLITEGKATIIQPESVFYNPVQEFNRDITIAVISEFATDHIQHVKELRQKKAKAAGEIGEADGTDLDAPLEAGKHHPHGMKILEGLAASGLRSMRFGHEIPGVQKIICNDFDKQAAEIIAKNITRNGLSELVEASCADASMLMYQNRFGFDVVDLDPYGTAAPFLDSAVKSVREGGLLCITCTDAATLCGNTPEKCFTMYGSLPLRSKFCHEMAMRIILRCLESHAARHSRYIVPLISLSIDFYFRIFVKVYSGQKKAKFSATHTGMVYQCSGCGAFKTQNLAEATPAKGDNFKFSATKGPPVAEKCEHCGSRHQMGGPLYLGPLHDKDFIHRVIGRVVSEGEGFRTGKRLEGMLSTAQEELDTPLYYEADGLYQTDIMRAWVNQLELKPKRNVPGTAGFKILSEKPSVEVDFTEHPGAIPKSRSQNLIRWQEKEADKNNSEADKDKNSDSENVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EC94</accession>
    <name>A0ABY7EC94_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_021885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="4">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR06516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="194" mass="21618" checksum="4C51C31CEB9669A4" modified="2025-10-08" version="1">MSERYSFSLTTFSPSGKLVQIEYALAAVAAGAPSVGIKATNGVVLATEKKQKSILYDDSSIHKIEPITKNIGMVYSGMGPDYRVLLKDARKQAQQYFLQYQEQIPTSQLVQRGAYFAWKATAMGKNFVNGKTFLEKRYSDSLELEDAVHTAILTLKESFEGQMTEDNIEIGICDHNGFRRLSPAEIKDYLASVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECK9</accession>
    <name>A0ABY7ECK9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="216" mass="23763" checksum="50F18D874ED42A0D" modified="2025-10-08" version="1" fragment="single">ESIVNDFYVTEYIGTFNVTQTENSNVTFTCTVDSNPLASINIRKDSTPRRAPGLDIKMNLTARQHENTTLQYTVFAFPVPSPSQFVWKKCTSSKKCSTLSNISGKTEITTIGLSSNLTIFDIAIDDYGVYSISIDNGIGEALVEMIYLKQAEISHVKPQTSTIAGGVTAGILTVLGILVVILVLRRKYSVTCAFKFTRKEGMNTVTTLNIMNLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECP6</accession>
    <name>A0ABY7ECP6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="143" mass="16173" checksum="8C8531431FF7730A" modified="2025-10-08" version="1">MVTTDTNTITMDILFSQVTSNTDMFFSLVTTNTDMFFSQVTTNTDMFFSLVTTNTDMFFSHVTTNTDMFFSQVTTNTDMFFSQVTTNTDMFFSLVTTNTDMFFSQVTNTDMSLPTLTCSSPWSLPTLTCSSPRSLPTLGHYQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDN0</accession>
    <name>A0ABY7EDN0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="279" mass="32171" checksum="E08323641C04D990" modified="2025-10-08" version="1" fragment="single">MNIVLSEISIWHCRSIPLDCNEFISNLLTIGSSRRIRLYYIACNHGRPTSNRAFPPTRVIAAPPSYIPPEPIRHKTAPYEPSVTAYSTRKIHGFVKAILQIFLQGILQIFLQGILQIFLQEYFTNLPSVYLTNLPSGYFTNLPSGSFYKSSFRVFYKSSFRGFTNLSSGNLTNLLSGYFTNLPSGYFANLPSGYVTNLPSGILQIFLQENLQIYHQEYFTNLPSSIFYKSSFKVFYKSSYRSILQIFLQCILQIFLQGFYKSSIRKFYKSSIRVFYKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEP6</accession>
    <name>A0ABY7EEP6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">THA11-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_017355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF143">
        <property type="entry name" value="SI:DKEY-56D12.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="26"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR07397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="417" mass="47266" checksum="E93D355B157BE2C9" modified="2025-10-08" version="1" fragment="single">MSEQPNPTTASRTGSPKTHGRYTGSVGDFCCVPGCSNARGRCNRQGLNISFYRFPKEKKRADLWLNRIRRGEMKDSKVVPFVPKGHYRVCSIHFEGGKKVDEPAHVAYIPTIFPRNSSIKRSTQRSKEADMNTPSPTTEKKMPRRIETSTSSGRPSTSTRLNFNSKLENAVWNGDHNYVACGVKTKVTDAETEELFIVLVKLKTGNFNEDLAMTFDISPTHVSSIFTTHINLLANELKILFEMQASDEEQANNLKVVLDCTELMAQRAANLDVRKKTFSNYKHDSSKFLVGLSPNLTTLGWESIRQKITLNSEGLMDHLKPGDAVMADRGFNVAMEFKKKGVQLLTPDFKGRDRAQITAEEARRSEYISKARIHVKRIIQRIKTFCFLERTMRLNMQDIITQVFIVCAYLTNIQMPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGP4</accession>
    <name>A0ABY7EGP4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_021695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF142">
        <property type="entry name" value="SI:CH211-69L10.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="29"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR06326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="149" mass="17104" checksum="822C778A5E325163" modified="2025-10-08" version="1">MFYQLGSMPICASREKFDNFIPEWFKELDPTTPGSISDQNITRQCGLISFLDKCDSVMTDKGFIIGKLVARRGAKLNIPPFSTKRDLFGKEDVEEMQIIATCNCWLNITALDSVLLSDFVPWNIDPRNLCMEKPEMIFIYSLSRTEQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIP6</accession>
    <name>A0ABY7EIP6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DMDD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_018765</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02334">
        <property type="entry name" value="ZZ_dystrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015153">
        <property type="entry name" value="EF-hand_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015154">
        <property type="entry name" value="EF-hand_dom_typ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF14">
        <property type="entry name" value="DYSTROPHIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09068">
        <property type="entry name" value="EF-hand_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09069">
        <property type="entry name" value="EF-hand_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="12">
        <location>
            <begin position="565"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="769"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="806"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR08807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="837" mass="96311" checksum="283C6DFEA5FFF723" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKW4</accession>
    <name>A0ABY7EKW4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EFCB6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_019339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052603">
        <property type="entry name" value="EFCB6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875:SF5">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="283"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="890"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="982"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR09381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1050" mass="119302" checksum="DE8A9CBBC90F823F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EL20</accession>
    <name>A0ABY7EL20_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_035754</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="3">
        <location>
            <begin position="42"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR10678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="396" mass="44999" checksum="7AB47FFF0EB25C4D" modified="2025-10-08" version="1">MDPQTDFESALNDRFDKIVLEGSWPINVVRRHFNNTAMEELSNGNIKDWGKKLNVKFIGEDGVDSGGLTREFFSLLFETSPVFEDNGFSYNADLLEKKHYQLMGRATSMAILHGYPGPRNLNRTIVDFILENKEPEEIPECCIQNAEVKAAIEEVSIARSSKSNRNSIKAYWNIETIGDVFERHSHLLEASGYKQLLSVSNRDRAIHTMNFYYCFYKYIPPMQQFIEGLKLHDMLLLLTKHGENGRALLCCDTKSSSMSDVLAFFVPKFSKSEHEKADEEMIVYNFGKFLKKVENGAISTDWVKMNSSEESLKEVTINLGDVLQALIGCRSLPRNIKSGEMEFDHLSNQLSYVNTCAPSIIFTRTKELVNYEKLEHHLICIIVEAEGFGLAGMAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EL62</accession>
    <name>A0ABY7EL62_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="95" mass="11483" checksum="E2F6017BF7B9030B" modified="2025-10-08" version="1">MFIVDPHPDRVEYQVYYSSQCSDITMDLLNVHYKDLMKAEKYGDILKTRQRNTACWRKVNLTSETIPKHVIRAIMFWNIYMELYADELYRNATRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPR9</accession>
    <name>A0ABY7EPR9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_036190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="8">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR11114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="106" mass="11921" checksum="3A006383FE72F880" modified="2025-10-08" version="1">MSAYQLYRNTTLGQCLQESLDELIQMGQITPQLALKVLLQFDKAINNALATRVKSRVSFKGKLNTYRFCDNVWTFVLNTAEFKDVGEIAKVDKVKIVACDGKSADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ES27</accession>
    <name>A0ABY7ES27_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="290" mass="33343" checksum="E46013BE25171D4C" modified="2025-10-08" version="1">MEKRHCLGIRQCLGPLWWGNICPDIIKGNAIDYMHCVLLVLWFDPKFSAMPFSMSSVVSLVDTRIKPLYFIKCHLSNIKEHSSHWKASEYRAWLFYYFIPLLYGVIRTDFFHHYLLHINIITKQLEYAEDMIIEFCGMYASLYGDQHMSANIHQLLYLGDTVQQLGPLWVYSCFSFESVNGKLVNLFHGTQNPVISIANAISSMLKIPALSDKLNVGSPAYNFFTKLTGVNHHLKVTETIFNGGIKLSNLDVKFFNVVGQCVGLAVGKCYLFQRLFNGTLFHCNMYHTHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESG7</accession>
    <name>A0ABY7ESG7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="109" mass="12519" checksum="082821AE19F648D0" modified="2025-10-08" version="1" fragment="single">MTRLLNEDEDMTNVVPSVTKIRIPCDQTRYGGKIGKLKNMKGSPCYMVKRLDHSHILIDGDIKRKACSAARTVHSTEKWTSFEILIFFTNAIDREFILIRYSNTAEVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUV2</accession>
    <name>A0ABY7EUV2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GBP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_003835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1000.10">
        <property type="entry name" value="Guanylate-binding protein, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003191">
        <property type="entry name" value="Guanylate-bd/ATL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02841">
        <property type="entry name" value="GBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate-binding protein N-terminal" evidence="3">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate-binding protein/Atlastin C-terminal" evidence="4">
        <location>
            <begin position="132"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR13730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="432" mass="50535" checksum="FBE62A92E6DE7A93" modified="2025-10-08" version="1">MGKNIRYGGKCNEDNNLLHCVLPGFVLALRDFTLKMIIDGRKVTPDEYLDVSLQNKTRKDGSFNKPLECIRKFFPQDKRRCFAFPVPGDGDTLESIDSLKLHDLSKTFQGVAAKFVSYIFSQEPKQLQVSKPVNGYMFASLTKQYVNDLSKGAVPDVDDAFTAVAKLENERVKKECLEIFQSRMDDILLPIPATKFNKHLTEARWCALKYMRENAVEDVANAVEKYAESLNDLKTELQNQTFEVLGGYKNFKRDVDIVKQEYEQALRDYEHREIVFPWSVVADWLGEAENRILEKDDALSEEEKQRERMEYSNSIERMKVEMAEANQTALDKQKNELEEQQKELNAERERLEKEHEHHVKMLQEKGMESESDKEHQNKARDQKKAKQKEDRASEYENTIQRLRDKIKKLKKMNKERKEKNIFSRVWNAICNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVZ0</accession>
    <name>A0ABY7EVZ0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_027592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR13412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19731" checksum="1DA717E2D7F49727" modified="2025-10-08" version="1">MNSLEGWPLGFASCEFWGYLSTVALACSSWHITIIVIERYFTHLLPSDADSTFSGRNTRILVTGVCLLMMMIVSGPFYGFGEYTYLRGFLNVIVSTNLSLPLHASHPEHQRVKLENLHQLFSHLQHSFYSSADTNLLTIIAKHLHDTYDVIVSKASWLPHGISFYIRSKNSDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWQ8</accession>
    <name>A0ABY7EWQ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ADT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_027326</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="10">
        <location>
            <begin position="98"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="528"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="775"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="529"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="617"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="806"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR13146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="914" mass="100699" checksum="B69CCAB33B103BFF" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXE2</accession>
    <name>A0ABY7EXE2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="142" mass="16025" checksum="E9E0E5D6ED3A2744" modified="2025-10-08" version="1" fragment="single">MPLPLRRKCFDIGGYDNADNHVLSKGDYSEHMVVLADLNSTVTFKKSVHIDRLKLAYIRQPVPLNYFKATTKVPEAIFRTSATQTVVEKSEQMEVPKVDNDGGYTRPKRLDKVKCILAPRDGPDGLAYLIHFVGEPAHISIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EYK2</accession>
    <name>A0ABY7EYK2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RPE65-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_004507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR14402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="210" mass="23875" checksum="A3A2241C6B4CAFB4" modified="2025-10-08" version="1">MDLVAYSNGELLENVYLKNYTSEQCENIARAMKPPQARRYVLPLNVSAENIKEDNIVKLPKSNASAKVVAKYLVHCEHEAICDEGFEMPQINYAKYNSKPYHYAYGLGVNNKEKNLFSLVKADVQERTHLKWEKDGCYPSEPVFVGNPDRTTEDDGVIISAINTVEFDKGRHAFLLILDARTMSEIARAEFPDVERFPRDLHGLFRADGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0R7</accession>
    <name>A0ABY7F0R7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="124" mass="13888" checksum="30995F10F1DB3643" modified="2025-10-08" version="1">MVFTWHVAKKSSIKSFTGHNMAYTSGQCDVTLVGEFEGRRTSRSAPATAVSRKEPFSDLSHFDILRCQQIGRSLENSVDNSRTATGEMFKLGGQFKFHHLRKSASRKEDVEQMLRTSGDAETGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F163</accession>
    <name>A0ABY7F163_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_004937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF28">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046958936" evidence="3">
        <location>
            <begin position="25"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR14832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="121" mass="12946" checksum="13BC5635B45EAAC8" modified="2025-10-08" version="1">MTSSVVVLFLIGAVVLLAVGQTDAIECYVCGLSFACNDNPDLAHTDVTTLTGCQSCSKIKINRFVTRECLLTAHAESCSEIDLLSTHTCYCSTNLCNSASHVTVSMAIALVLAFVAMLFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1K9</accession>
    <name>A0ABY7F1K9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TENN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_030659</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF5">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045426252" evidence="6">
        <location>
            <begin position="27"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="7">
        <location>
            <begin position="71"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR16065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="287" mass="32858" checksum="8FA103095D51BA86" modified="2025-10-08" version="1">MTYFKMFMNIFYLLAFFSQQWGLTLALNFQCSDVNSMHSNNQEVSSRLRALEEQMLQVQSLLQGGTRPSYTTVQGYPEDCEEIYKNGTRVEGIYAISPDGRCPFFVHCDMTNGGWTVIQRRINGNVNFFRDWDDYVHGFGDVDGEFWLGLQKIHRLTQGGSQIYFGITNYDDTTDFAHYQTFTVHGAATKYRMNVDAYGYQGSINELFTFHDNMVFSTYDRDNDVHATANCCADHGGGGWWWKNCYKLGNVNGIYGKMTSGGLVTVTSTLHRKNGPEKRRPPRRRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3W9</accession>
    <name>A0ABY7F3W9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_031439</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="74"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR16845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="345" mass="38415" checksum="D151078DF54C05A6" modified="2025-10-08" version="1">MASNNSMQTPLVMLNDGYDVPLVGLDNGMFYFIQIPAVVCLVMSFICALSTIISSFWSHPAGEFYARWTRGERLVVYMSICDLLSSISLLVNHLQVLITKMHARPKGLCAFFGVITTEFMLAQILMVNVVAINIFAMMFFNTKISFGKFDSGILVWSFGVPFIGALIAALLEQFGPMVLVCHFDAVNGKVGGLVLITIPLTTIMVVNVLLYILTFIKIRIEVIAARECLGKMTSTAHRHIRAARNMSMFVVSLFVQWSIIALVGTWVMFGDKSSRLPEILYFFIIVLTNIGGVLNLIVYLAIFKKTKLTSKMATDMESRKTHSFSDNNKTPAYGSGQGNEEFEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3Y9</accession>
    <name>A0ABY7F3Y9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="63" mass="6631" checksum="1B190FB4299F8EC2" modified="2025-10-08" version="1" fragment="single">MSVSSNFKKFIRSPRSKNKHSKSRNSKDSDVTSPGGSGQVTSSSASNGMANAKTCANEGNHDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5B0</accession>
    <name>A0ABY7F5B0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tetratricopeptide repeat protein 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_030487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC38 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd05804">
        <property type="entry name" value="StaR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033891">
        <property type="entry name" value="TTC38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16263">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16263:SF4">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR15893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="305" mass="34692" checksum="BE3398785D4BB072" modified="2025-10-08" version="1">MHTHWRDCKAWKDYGTPVNTTSNEAAKMFDASLTQDFIFIYVGWYDDMSVGGIEKSLENTLKADPDFDCEPLLVVALHNPFSLVMGHVIKNGLDLLGTGTNVRLNADLATDIATMVKMGTSQQGLSNREKKHVNAVKLWSEGNMALACDEWENILMDNPYDILALKFAHDTYFYLGFSRPMRDSLGRVFPQWKEDKPLYGYLHGMYSFGLEETNLYEQAEKIASKGLELNPRDAWSTHSMAHVLEMMGRQDEGMKFMSGTEKDWQTCGMLSCHNYWHWALILIEKGDFSGALGIYDNHNLPYTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5D5</accession>
    <name>A0ABY7F5D5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SREC2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_031168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045779724" evidence="2">
        <location>
            <begin position="31"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR16574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="152" mass="16754" checksum="F4D0A4D5D3AB2E4C" modified="2025-10-08" version="1">MKDRMMKVTSGSTIIALTTTILILIVQGRCQECEEGRYGNLCNVTCGQHCLNNRCNQDDGSCTCEKDYKFKCGNCILMTCPANCSTCTSLDKCDTCVDTYYYGETCEHECSHCKKGTNCGKTDKTVGVNVLMVSLAIFVIALVTQDVKHVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5E4</accession>
    <name>A0ABY7F5E4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TEMPT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_032012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057626">
        <property type="entry name" value="S-S_Temptin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055313">
        <property type="entry name" value="Temptin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34737">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34737:SF2">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24784">
        <property type="entry name" value="Temptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046487155" evidence="3">
        <location>
            <begin position="27"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Temptin Cys/Cys disulfide" evidence="6">
        <location>
            <begin position="25"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase N-terminal" evidence="4">
        <location>
            <begin position="164"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase C-terminal" evidence="5">
        <location>
            <begin position="298"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR17418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="457" mass="50336" checksum="C0A7F2B495C217CD" modified="2025-10-08" version="1">MTVNMFTCSFRFTCLIVAYCACAVSGYDYFRNDIPNGHTVPHPCNSAKTWDGVGHQTQEGGTARNPFGLDWKDNGQVWNSSICEKDSDGDGRTNGQELGDPDCTWTIGTNIAAVASSHPGICEPIRSAMCANKNSFLDCGKQGFQCDAINQPDVFNISISFAPGTRVPRQETTYMCQAFDLPEVATSSTNHLIAAIPNIVNPTVAHHMIIRGCSSDVGSPGVCLPDEIGFAVGVGGYKQVLFEDQLRIPPLQPAFDVSGRCSGTCLDFIYDENYEEFKIAGAFNHAHLTGSAVVTQVFDKAVSVRRGQELNVTCTYNTMSRTQMTYYGEGTRDEMCFSFLLYYPKESLTDHQCSQKGQTDKCLDVGPEQELEFGARVWTACSLFECLDTCKAVAMEADKNPCFSGNRKRAVLENASTQDDVERAAQVFEFFVRLDSCRTEMAMDQCRDDQGMIPETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5Y6</accession>
    <name>A0ABY7F5Y6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR17565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="79" mass="8867" checksum="3DAF2D48437F9CE1" modified="2025-10-08" version="1">MASFQGLAYTMLSRATNRSGIKSDIVVNKKAVEEITRMLSESLLEIPLYLHGNGLYIGHTNIRSLRKHACDQIHDPTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7S3</accession>
    <name>A0ABY7F7S3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_031665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="83"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR17071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="335" mass="38776" checksum="80D3414BEFD1B468" modified="2025-10-08" version="1" fragment="single">AQDRTYYNEGQVKRESTKPIPTISRPPANKPNAAKHQVSTHEETAFESEIDLEIDDERNGALENSSRGDQTYYNELGSSTIKSKVHINQLVKYVDGKTYDAFSAEFEGYKKPKQYIATLGPMSQQLDDFSLFWKMIWQQRVEKIVMVTNLIEHGTPKCEQYWPNPGVSKMYGEIKVESRSEDEYAEFTRRALTMTMGTEERTLHHLHFTCWPDKAIPDDVTAMIEFRQRVQSTPSTLNGPTEQYQFLHTAVVYSLTFDCKQIKGENFDQFMKQHTSKELNSQFKRLQHTVEKRTKDEAIAVERNKQHLSKNRANADIPGNENRPRLYLNLKHGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8B4</accession>
    <name>A0ABY7F8B4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G137B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_000280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029723">
        <property type="entry name" value="GPR137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15146:SF3">
        <property type="entry name" value="THH1_TOM1_TOM3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR18442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="165" mass="18290" checksum="5DE9D9F36B5DD71D" modified="2025-10-08" version="1">MYDDQATSLPYAMLLIRVTINDTLFILVSLCLSVCIYKLAKMAAASVVLEAKADFVQLDKGYAYASFAVVLFVWEILPMFIVIGLNDLPSHTQNTRAYFFDNPRRYDSDDDISAASDYFHSHQSDSSQGRYSINASQSRASIDASVETLRGSPRTTLPKGPTLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FA81</accession>
    <name>A0ABY7FA81_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ZN479-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_000838</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="560"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="781"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="862"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1059"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="789"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="862"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="883"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="906"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1081"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1106"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR19000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1129" mass="127227" checksum="3B92922640CFAC8F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAW0</accession>
    <name>A0ABY7FAW0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SRBD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_001146</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.310">
        <property type="entry name" value="Tex RuvX-like domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050437">
        <property type="entry name" value="Ribos_protein_bS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF10">
        <property type="entry name" value="S1 RNA-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12836">
        <property type="entry name" value="HHH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="551"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR19308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="662" mass="73607" checksum="6BD438B15331CFE9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FB46</accession>
    <name>A0ABY7FB46_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="204" mass="22692" checksum="7093EC79C895641B" modified="2025-10-08" version="1">MTKSFENEDKACKSKFLSLLESDLKTIDGAEELSTNVHQKYIWYIIDIFILQQNGDGEEIYIDGNASTMLTLGVNGLRKYALYIDKQTRFNTIKCLLLKTNARSPSVDAFILDIDTPVPGYVSTIEGSSKKTTFFYDETDSSKSCHPTTIPDIVIIDQVEIGAIDGLGTGAIVGIAIGSVTGFIALVAVLCWCCRRNKWRYRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBH7</accession>
    <name>A0ABY7FBH7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_000357</name>
        <name evidence="9" type="ORF">MAR_000421</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF88">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR18519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR18583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="142" mass="16457" checksum="044D874D11EA7382" modified="2025-10-08" version="1">MNELVAKFADKLVIIAFPCNQFGHQENGSGEEIYASLKHVRPGGGFEPNFQLMEKCDVNGAKAHELFDFLRNRLQTPSDDSVSFMNNSKNIIWEPVTRTDIAWNFEKFLIAPDGVPFRRYSRYFQTKNIQHDIQQLIDKFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDN2</accession>
    <name>A0ABY7FDN2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DHYS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_002098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR20260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="337" mass="37560" checksum="F89357EB5B064243" modified="2025-10-08" version="1">MQEESVEIIPSLAVLKKSESMPDGTPTVRGYDFSEGVDYHKLLQSYATSGFQAQNFGRAVEEINRMIHCKLLPIDDKNVKELIGHPTGRSRTNCSIFLSYTSNMISSGVRETIRYLVQNNMVDCLVTTAGGIEEDFMKCFAPTYVGDFALKGHSLREKGINRVGNLLIPNDNYEKFDAWIIPILNTMLQEQKEKGTLWTPSRVIDRLGREINNPDSVYYWAHRNNIPVFCPAITDGGVIKHHTCNANLARNGADFAVYLNTAQEFDGSDSGANPDEAVSWGKIKSNAKPVKICAEASLVFPLLVAETFSQRQNEFTAPTPRTETTAQDDTGKNCEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FF88</accession>
    <name>A0ABY7FF88_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHTK1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_001254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="494"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR19416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="842" mass="94360" checksum="3F867D6B625169AB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFP9</accession>
    <name>A0ABY7FFP9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TEuncharacterized</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_001391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="212"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="438"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR19553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="652" mass="73583" checksum="F34E5119BDD1C8AF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFQ8</accession>
    <name>A0ABY7FFQ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="113" mass="13365" checksum="68D9C237A26BFB1A" modified="2025-10-08" version="1">MTSDKSSDRLKSDLRSDHSRVGLKSGINSDHRKYGLKSGIYFDNRKYGPKSVHHRVGDPLEKSRVRVDVSKFLKRKRKDKKYITKWNTLDRTNFIENYVTSIEVTWIYKKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGW5</accession>
    <name>A0ABY7FGW5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">HMX3A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_015274</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the HMX homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051300">
        <property type="entry name" value="HMX_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46110">
        <property type="entry name" value="HOMEOBOX PROTEIN HMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46110:SF3">
        <property type="entry name" value="HOMEOBOX PROTEIN HMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="73"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="75"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR21300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="174" mass="19488" checksum="C687768A968F44F3" modified="2025-10-08" version="1">MAWESEQGKPHEDTDDESDIAVDDVTMKGAIGVRKSTASPSAMETESVADVLSKSYSNDGNSSDENDDDKKNRRKKKTRTVFSRSQVFQLESTFDMKRYLSSSERAGLAASLQLTETQVKIWFQNRRNKWKRQLAAELEAANMAHTAAAHRMVRVPILYHDNASAPGSGSENRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHT3</accession>
    <name>A0ABY7FHT3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HIPL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_002329</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HHIP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018143">
        <property type="entry name" value="Folate_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328:SF75">
        <property type="entry name" value="ALDOSE SUGAR DEHYDROGENASE YLII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328">
        <property type="entry name" value="HEDGEHOG-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03024">
        <property type="entry name" value="Folate_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047155318" evidence="7">
        <location>
            <begin position="29"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Folate receptor-like" evidence="8">
        <location>
            <begin position="41"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose/Sorbosone dehydrogenase" evidence="9">
        <location>
            <begin position="219"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose/Sorbosone dehydrogenase" evidence="9">
        <location>
            <begin position="361"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR20491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="525" mass="59742" checksum="3BE5B4CB61C085CC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJC0</accession>
    <name>A0ABY7FJC0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_001184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046408241" evidence="2">
        <location>
            <begin position="19"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="415" mass="47606" checksum="27F6552732604A1A" modified="2025-10-08" version="1">MDLKILFVLSFLYASVQTQKKERRALNFLSFVSTSVEIANFVQGIVNDNDQDTASPADLEKAKNEILTIFSEKLDVVQEQLYGSIKETMSLSKIDEVSYKIQSVVLDLRAYLLANENEQIVKKEEFQTQAALIIADIRSLPSRLEKSLANADLSLLELMATNSKCNMTGINEFKDFFFNLTQTGIIIEFSYKTIKQNSTLQTESEWWDSQVRQMIDSFEREDSTCKSRFHTLLRSDMEKHDNLKELSNMVHQKYVWYIIDVFILKQNDDGEDINIEGKETNMMTMSVNGLRKYLIYIDKQTRLNAIKCLLLKSNIQAPLDEVFILDKGTPAHGYVSTIEGSLKKTTLLYDETDETRSCHPETVPVDAVKDGTNEDDGLKEGLNIFLIRLGIGLGSLLFLATFISVCYYWYRRRCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJF1</accession>
    <name>A0ABY7FJF1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peroxin-13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF4">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16270" checksum="6595CA4A80EC2346" modified="2025-10-08" version="1">MGGYGRGGYGHGGYGGYMGGYGGGGYGRGYGGHGGSYGGHGHAVNLASGLAETVTQWQLERNGKGPAVTTDNVSNIVRAVKESSLGPHMGCFANTINLATQRGRKVQQVHRVLGRLRRVVTYVHKSTSVTSCLKLMQTKLDIAQHKLLLDVPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FM44</accession>
    <name>A0ABY7FM44_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NEP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF240">
        <property type="entry name" value="GH14155P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="112" mass="12630" checksum="4DDA871B37B49812" modified="2025-10-08" version="1" fragment="single">IHGAQTLEENIADNGGLRAAHIAYELWMQEHGEEETIAGLDLDARQLFFVSYAQLYCSKWSMSGVTDFLMRDAHSPGPYRIEGALSNSLAFPDVFKCSYVAKYNPPIKCRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNN0</accession>
    <name>A0ABY7FNN0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CFAH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_016272</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051503">
        <property type="entry name" value="ComplSys_Reg/VirEntry_Med"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45785">
        <property type="entry name" value="COMPLEMENT FACTOR H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45785:SF2">
        <property type="entry name" value="COMPLEMENT FACTOR H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="158"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="217"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="321"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="414"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="516"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="574"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="587"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="99"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="160"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="219"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR22298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="640" mass="68207" checksum="A04C3655E4FDA227" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPP4</accession>
    <name>A0ABY7FPP4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Immunoglobulin I-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047470004" description="Immunoglobulin I-set domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin I-set" evidence="2">
        <location>
            <begin position="263"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="398" mass="44245" checksum="84FD36A3523F67FC" modified="2025-10-08" version="1" fragment="single">MELYVFIFGVCCLHLINGQHVMPAMTDKAPIELHHIFVTSRIPGRLEASICYTAMNPAQVVWTIDEGMVPTLRIPANMPFSLIRFHIACKTHSYRVHVALDVKHGMPDTFEAVNQFSLFIPPTSEIGISPKGEARLHAMVNSTGTTFRFGIMQAEIALYSKRPNDIAHSYFHPSAAYSFLPGDETSPIRLNKIAQTATEYHADVILNSTKLYNQGAIVSVMGACTVAGPTIIKRYDQKLVMFLNPTSTAEPVTSFTLGFLDEAYDILVEKNKHGLIRCTLIGNPTPEIMLHKKTPSGGSVRITAPNYSTHMEYKTTTVFHIINASEADVGEYYCHATDGVRNVETQTHKLGIVTPEMENQAKEERVEGDVDGLVAMEQLAKRHPRNVPLVHELEGNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPW9</accession>
    <name>A0ABY7FPW9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SNED1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_036868</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF9">
        <property type="entry name" value="NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="139"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="194"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="231"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR23199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="312" mass="33883" checksum="754461DD24D79043" modified="2025-10-08" version="1">MSIGAKNARIGYMSFGDNITHHFYLNTYDTTNNALSALRAIRNDNIPQGIEAAVTKFTTSNGDRSSTPNYLLLITDIYESGSDTKIKEAIAAGIHVTVLVRGPCSTQYQALADECFGDLSSNLEKIKSSVLGYVCHHTQDCGELITPDGTTNGTETLDGTVRYLTCNAGYQQNGTGLIRCESDGAWNITSTCIDIDECQSGPCRNSGSCIDFVNYYECSCTHGYTGYDCAIDCGELVTQGGSANITEDSTVKELTCTVGYTLHGTGLIYCEEEGGWNITSYCVPNVDEKTCSGLFRMYRPRLFICDVHGRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQB0</accession>
    <name>A0ABY7FQB0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_038064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="173" mass="19799" checksum="DCEA9C3DE0F6D96E" modified="2025-10-08" version="1">MSMDFRKTTYKPQRADNRFRTSYSLMSQWMNRKGSAQVYRKEPLPQTFQIAMQGNAAFPPRRNPSFSAGDRYGQMSKSMDQMPPYEGQGVIRWADGVKADEVPAGHLINPRVGEIKSRYMVPSRQQPSARLVKGSRVGSTENLAKKEFHQYPPTFWRSSTDIPDFVSWGKSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQD2</accession>
    <name>A0ABY7FQD2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KLH17-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_038021</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="8"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR24352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="374" mass="43225" checksum="6C6279E9BCDB84B4" modified="2025-10-08" version="1">MDQKAASSLVNLNVDGKLLTCPRDVLVRESDYFRAMFDSNMMESNTKSVTLHGQMKSAIDTCEGYFLTALDDSNCFELADLAKANILHRLYNEAKRHSLFYFQSVRKYPQFLELNAVPLKQYLSSCYLNCKTEIEIVDAINDWLNHDKGSHCLTARAWMKDKSSLGDLSLHMNRSDVLRGKFVNEVWKYDGFHGEWTSLHNFPKSCYDSGMTYTSDRIFVTTPSVYVYTLRTNTWASVCEDKIASEWITTQITPLEYDGDLYLCPKDGFKLCSDCFNVDENEIYRSADGWSVFDLQKYETKLGIQSMTFFNQTYYSVTHDGVLWKGNLFSDRLTLKRLNKEHELIGHYKPIAVPSYPYFKISEDCSNTEDCKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FR04</accession>
    <name>A0ABY7FR04_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">FBN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_037141</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052080">
        <property type="entry name" value="vWF_C/EGF_Fibrillin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333:SF4">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333">
        <property type="entry name" value="VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="AMOP" evidence="10">
        <location>
            <begin position="163"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="11">
        <location>
            <begin position="304"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="697"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="907"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="966"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1008"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1048"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1178"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1237"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1323"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="1052"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="1333"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR23472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1483" mass="163655" checksum="1A3DBF7AF25C1890" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTE3</accession>
    <name>A0ABY7FTE3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047194715" evidence="1">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="108" mass="11520" checksum="6D7CAB1428F50768" modified="2025-10-08" version="1">MVKALCVLLIAIVGLSAVQGFIRGYGYGGLYGGYGNGGLYGGYGYGRMYGGYGYPGMYGRGYGGFYGGYGNTGMYGGYGYPGMYGGHLGMQFYRYPSYGYGFGKKGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTI6</accession>
    <name>A0ABY7FTI6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">MLP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_037705</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF465">
        <property type="entry name" value="EGG PEPTIDE SPERACT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="119"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="223"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="329"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="491"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="14">
        <location>
            <begin position="589"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="14">
        <location>
            <begin position="644"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="14">
        <location>
            <begin position="700"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="14">
        <location>
            <begin position="758"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="14">
        <location>
            <begin position="863"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="14">
        <location>
            <begin position="925"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="13">
        <location>
            <begin position="1260"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="15">
        <location>
            <begin position="1409"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="1862"/>
            <end position="1905"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="1988"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="2113"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="953"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR24036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2331" mass="256602" checksum="A6589CBF3319E9FF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FW57</accession>
    <name>A0ABY7FW57_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_010670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR24966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="36"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="134"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR24966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="200" mass="21888" checksum="E995F8523E213164" modified="2025-10-08" version="1">MQYIIVIHFRERSHTVCKNNAIVAQPTYIASLGIPSPCTAQSLQAGRIFFSVANSNKQFIQCDAVGNARVITCPDQLIWDQNRQSCVYTLQGGVANPGYLAAVTVKLKKIIRLCQFVLKNENDCEFAGFLNGANPCTAQAISAQALFFSHPDPTKFIQCDLQGNAFVQRCPSGLVWNQYLETCASQLASITLTGQTNFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXK5</accession>
    <name>A0ABY7FXK5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="136" mass="14747" checksum="24560B215569F190" modified="2025-10-08" version="1">MVIACCLKRDGHTLKSLKEHCHASQEQSRNVNVQTISVVLKDYSNDPVSKGNSAVDDSSEPELAFWCRAGCVSTVCVSALIFLALPAGILLCVYASNNADNELLTVGIIISCLPILTLPLIVLVLFNRRCIRSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXT2</accession>
    <name>A0ABY7FXT2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DCR1C-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_012494</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="85"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="610"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="851"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="905"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="999"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1056"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="519"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="632"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="644"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="917"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1073"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1156"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1189"/>
            <end position="1204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR26790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1250" mass="140538" checksum="30F0460C966D8FE8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FY23</accession>
    <name>A0ABY7FY23_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">STE20-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_011430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26392">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26392:SF92">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1000"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="776"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR25726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1303" mass="149190" checksum="E09CAE4FACDEA1E6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYN9</accession>
    <name>A0ABY7FYN9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_011555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR25851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="155" mass="18209" checksum="837D12344C09C4CA" modified="2025-10-08" version="1" fragment="single">MYNQAKKKYQLNKTELTKDNLTQATQDMYVTNSTCGTEFSLDPSDDIRFHYDGGKVYDPNRSIYGRCEVKITNNHKGAELCVWAPYSRYTGVKNIDWTLKCSEMFQFGFTYRLNTMSCDEFLINEKCDIAKIAYATFREPFFHDEESRLNEINYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZ10</accession>
    <name>A0ABY7FZ10_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Superoxide dismutase copper/zinc binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_012098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047391120" description="Superoxide dismutase copper/zinc binding domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="3">
        <location>
            <begin position="82"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR26394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="259" mass="28632" checksum="BF2B13CBD98DD55B" modified="2025-10-08" version="1">MHVLWLHAVVIAACFVSTINGRPTDTKYINQFDLFGLWGAAPPPPPKVTRAVIKQEKDEETLHGECHLVPHVRNSRQISDVFGTIQLIQKVKSGEAGPLRVSVRIDGMPTVGMWGKFYKLEVHKYGDVTRGCRAVGPIHSTQATSGHLGDFISNMYGEVNMDINDAASTLYGNGSIFGRSIVMTGMFTQDPLGCCVVVRDRPSHEFARGPEIPTLKQEVISIPRPNVSSTVRDRPNHEFARGPEIPTLKQEPFPIPLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1H8</accession>
    <name>A0ABY7G1H8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18605" checksum="C011F7BFCDA0207D" modified="2025-10-08" version="1">MRSCSLNIVALNITGLFSNVSYLSDLLHEGYIDIIGICEHWLYPHKMHFLKSVSSDYSFHAVCDKDLNINRAGVGEGGLLMISIDDNHIAGIQLQLCSNQHIYHIYKVYLPRVNHTINVFIKYIDKLFDLYYSYCHTGIPFFMGDFNAKVNTQSMSSKDKSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2P4</accession>
    <name>A0ABY7G2P4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TNF family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_013233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR27529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="43905" checksum="339C86D14660E0E4" modified="2025-10-08" version="1">MEKVHDIESMTGNDFCINCRDGKRTRKSKTLKCILVVLLISVIGAAISVIVYSLHDDHRVKRCSGHENDQTDTIMNLRDKVASLERRFRKIRQLINNKSRQIEDDTFVRTMVEYDSNKALSKVLVDDIGTEKERAGLGFATIGNDARIGSGRVRRDATDNKKVKRKGKKVKKVRRPKKKKYKMKEYDPPLLKDIEKFTNRLSWVQVTGNALRERRDDKTVTNVNVDGRIKVTSSGFYLIYAQLKLFGKSRHGFHIYRVSKTGTKVLGTCKVTGFPFESSETCFTMQIVELEENSEVYVAFINVTAKGYNVYHVSKGQLSQIASCFLNTNTCGAIGNKTGINQTCSTMKVYPLLEGDAVYIQEISEINVGYYSSDHSYFGLIKVDDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G370</accession>
    <name>A0ABY7G370_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ISP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_013297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051004">
        <property type="entry name" value="DC-SIGN_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22802:SF396">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22802">
        <property type="entry name" value="C-TYPE LECTIN SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046015546" evidence="2">
        <location>
            <begin position="31"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="125"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR27593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="239" mass="27383" checksum="B98F3269EA3F9CB0" modified="2025-10-08" version="1">MLLVALKKDVNMKAALFCLSLLQLWTSTNGEISTHEYQRYTDSSEITGTSIAKTTARSLVRCTTLCAQHEEDDERCHAARYHGETRACELISRSSTGTERWLNDGSWTIVASQDAEVCGDGWHCNEGSSYFVSDEPSDWFTARDRCMDVGATLASIKDQTENTYLKDLLKTYGSNFYWLGGSRASPKNPWLWETGEAWGYEDWEYLKTYLCMGIWVISYNGWHDWDCMHAYRYVCEKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6T4</accession>
    <name>A0ABY7G6T4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_003706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR30138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="459" mass="52954" checksum="9CFEC26103964C2C" modified="2025-10-08" version="1">MTIIYQYKVASASFLGFFRLLKAWRGSVYKLIYKETIVFCVMYAIISLVYRLALDATQRRLFEQLVGYCNAYTNMIPVSFVLGFYVSLIVGRWWTQFTNVPWPDRTLYIMGSYLVGRDENRRMLRRTVARYMLASLVLILRSVSVSVMKRFLTQVEVAMFENVRCKYNKFWVPLVWANTVLTTARREGRIESEYGFKFVLEQIADFRDKCSICFVYDWITIPLVYTQVVTLAVYMFFGACLIGRQYVENEDDMPDLYIPFFTLLQFLFYMGWLKVAEQLINPFGEDDDDFDMNWLLDRHFTVAMNLVDYCHSVHPPLVKDVHFDDVAKEELPYTEAAMGSRRPNFMGSTYNLARPSTVSQRNVPNPEAYEAARMNNGSFAGLRKRSNATMRAGAVGSGSSWSLFGNRSSSPNRKFGSRGRLSYLANGNPALGPLNFLAPPNAEYPQMENRDSRSSHPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8M6</accession>
    <name>A0ABY7G8M6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="512" mass="60616" checksum="5B183CF0048B906D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8X9</accession>
    <name>A0ABY7G8X9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="370" mass="41702" checksum="E534548836B6615E" modified="2025-10-08" version="1">MAGVEDIDDETRADRLEKVKECNTELLISIAKLCKRTDRTYPEVVFLLGTPGSGKSAMVNTIVKALCGKFYSKAVTGKGHASTKTLTLQSFVQCGLKEDDLEPVEKDILNEGLSKLPTVIDASGKGDEDSEKIKEILRVYFGGFVPPGTSIQCIEQLQEDNGIGSLQELLECSDENKVTKVVFVTSCKQSFPEKLLESLHSVLQEYDNRSGKPKYPVDVFVVITKYDLVKDQHIYEARDKEEEYITEECFQKFEAEVAKHFSIEGAIENNSIRWVSYVDGHGSDNPHIDNIALRFVEKMMQPRRGHDYGKPSKKPEENVPLVPMSKILKFQAKKKITEVSREMDWKCGFIFALVVVLLAVFYRLLTKDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9P5</accession>
    <name>A0ABY7G9P5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="669" mass="75614" checksum="91DAB55632A05E0F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9X1</accession>
    <name>A0ABY7G9X1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045740432" evidence="1">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="123" mass="13631" checksum="1CCEAF9570E632FE" modified="2025-10-08" version="1">MTLVIVWGLSIATSVVFAQEGICKLQEYPRPADYTGDKYETEVFQTNNNITFCDQQACRGISNEELNACNDGSFPSFDEYLRLLKYTLKSKSDCKLTGDPDACQAVDANGNPAHDGDKCCRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GDJ7</accession>
    <name>A0ABY7GDJ7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="124" mass="13944" checksum="46D3E3597398390C" modified="2025-10-08" version="1">METISNPTGKGKRGHKWGACKSDLHTVTITCIGSNKQKPSTFDFSEVKYKPVGTEKECRAAIKSYNNCSLSEIGILNKDRMESHTALKPLREQIQPLKEIITPGISIAIIIIYMFGQYNWSRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAA0</accession>
    <name>A0ABY7DAA0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">WW domain binding protein VOPP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Vesicular, overexpressed in cancer, prosurvival protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MAR_007062</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">MELC-2E11</strain>
            <tissue evidence="19">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Endomembrane system</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Late endosome membrane</location>
            <topology evidence="13">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VOPP1/ECOP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026229">
        <property type="entry name" value="VOPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14971">
        <property type="entry name" value="VESICULAR, OVEREXPRESSED IN CANCER, PROSURVIVAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14971:SF2">
        <property type="entry name" value="VESICULAR, OVEREXPRESSED IN CANCER, PROSURVIVAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="171"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WAQ94591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="218" mass="24488" checksum="6537CA40A6F61929" modified="2025-10-08" version="1">MWGSPLPKLPSVNPRPIISIDANDQHYGLHLPEIPEFPDFTECKYCWYKSGFGKSSHFYCSAFQYCCGDKCCENIDEFYKLLCILVLILSAFVAFYWLRNHYGNNRSAQEQRSRSHRRSRSGRRYRQLTGDSVTSAPSVIIPDSVVTAPPPYMGDNTGCPHLGPPPYFLGSGSSINSQPRFPPPYSKIEKQPPPSYSSTVEIDVVDSNGAIHGKSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDQ3</accession>
    <name>A0ABY7DDQ3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="126" mass="13758" checksum="F06329324AD015EE" modified="2025-10-08" version="1">MSIGEPMLSCSVVGDEAQRETDSGQQTVEMHHQAKGHVFLATVVISGVLPRAQSSFKGMRLSQSFLRAFNNTAEEVNRSLQMIENEVPWLKYMEVPGFTTAGGIDSKLLSRDGLHLSFLGTETVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDQ8</accession>
    <name>A0ABY7DDQ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_028481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ95791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="177" mass="21061" checksum="9D0081E7AB2573C1" modified="2025-10-08" version="1" fragment="single">VTTGTSQVFRSAEKVKKKYKKSQSPCKDKIVRKRRALYDVQIKKHNLSYSYLYRRVSGETAIDSRNGPGTVFSRQEVTELAQYLSEIAKRGMGLRLCEFLDLMQDIIRKENRKTPFTNDRPSYEWYKKKEVLLEASRSRLTSERFDKWYSNFRDFLAEKDLLNKPERIWNVDEKRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DE96</accession>
    <name>A0ABY7DE96_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_007511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="3">
        <location>
            <begin position="318"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="853"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="880"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ95040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="984" mass="111041" checksum="DF5323438FD50DEC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DEI8</accession>
    <name>A0ABY7DEI8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CEIP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052252">
        <property type="entry name" value="CEMIP/CEMIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055401">
        <property type="entry name" value="CEMIP_beta-hel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15535:SF17">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15535">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24606">
        <property type="entry name" value="CEMIP_beta-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="10"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="538" mass="60208" checksum="57005F9BB5F7D473" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DF90</accession>
    <name>A0ABY7DF90_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NETR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_028075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRCR" evidence="3">
        <location>
            <begin position="7"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="3">
        <location>
            <begin position="64"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="3">
        <location>
            <begin position="173"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="210"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="223"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ95385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="284" mass="31804" checksum="FAE88E9EB8A439D5" modified="2025-10-08" version="1" fragment="single">MQQDTRVQLRNGINRYKGRVEFQYNGIKGTICSEHFDDKDALVVCRAANIPGNQYVELRPHTPIRLTNGTKYSGRVEIEYEGKWGTICDRDFDENDAKVICRMLGYNTRSVEVKQNAYYGIGDGHIIISNLACDGNEPDISECLTAGYKWSAVHGYCTAKNDAAVQCRATSLVRLVSEDGQTTYKADIQGKASSTGRVEVFYMGKWGTICDDLFDNQDSQVLCAMMGYSIGRVNKSSYNNFYGDGNTVIDDLECAGVETDISQCKSREWGTHNCIRQENVFIDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGZ5</accession>
    <name>A0ABY7DGZ5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HS3S2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_028941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF72">
        <property type="entry name" value="HEPARAN SULFATE 3-O SULFOTRANSFERASE-B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ96251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="263" mass="30668" checksum="6D51C173AF340ED7" modified="2025-10-08" version="1" fragment="single">KSQSSQPPIEAIRRIPKVIIIGVKKCGTRALLEYLKLHPLIKAPGPEPHFFDRNNHPTNDHEITIEKTPRYFVSQDVPEKIYNMSPNVKLVVVIRDPVIRAMSDFTQAVSKHEVKSNLTFRKRVLRRDGDINMHSSVVKTGIYVRYLTNWFQYFGRSNIHIVSGEDLIANPLGVLETVQDFIGVQREIDGNLIYFNKTRGFPCIRMLKRNNTAKCFGATKGRNHVQTDSTTLKRLYDFYRPYNQYLFRLINKTFEWNELQKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DH82</accession>
    <name>A0ABY7DH82_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BL1S2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_029737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019269">
        <property type="entry name" value="BLOC1_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46479">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46479:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10046">
        <property type="entry name" value="BLOC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="182" mass="20488" checksum="E4E439E79FCDD680" modified="2025-10-08" version="1">MYGYAALPASDGVTIRVGNSSTTFLDAGGTLPSPNTLKGIGDLLEYHRQKMAEEENRTPNRTGEQKRDVRDSAPPDIVELCRETFKKTSEYLKGELDGTIEDYKLLETMNKVTVSKYSEMKNTAGEIGGALQELNEKYENLLPFLEQIDHVEDSVNSLEQAAYRLDAYSKRLEAKFKALERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHS7</accession>
    <name>A0ABY7DHS7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TMM26-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_029932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168">
        <property type="entry name" value="TMEM26 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="556" mass="63696" checksum="9F3E658DC104128F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKG2</accession>
    <name>A0ABY7DKG2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZFAN4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_030063</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01802">
        <property type="entry name" value="Ubl_ZFAND4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053061">
        <property type="entry name" value="AN1-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46728">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46728:SF1">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="286"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ97373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="560" mass="61748" checksum="EF0BAA77DD762517" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNY5</accession>
    <name>A0ABY7DNY5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="13814" checksum="D12979204107E040" modified="2025-10-08" version="1">MCPTRTNAEDPRFNFTSTDNAVIIKLFSDDSVQKHGFLLKYVENLSETTTTTTTQTTTTAMRTTTTNIDTSSTTTPTTGATSTCELDIAVVAGSAAAGAALGVGVVGAIWAIQHQWLRNVKRVQPFAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DP74</accession>
    <name>A0ABY7DP74_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MAR_023286</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">MELC-2E11</strain>
            <tissue evidence="18">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005919">
        <property type="entry name" value="Pmev_kin_anim"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13101">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13101:SF1">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04275">
        <property type="entry name" value="P-mevalo_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WAQ98913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="175" mass="20015" checksum="04B22895F2164680" modified="2025-10-08" version="1">MKCERHHLLHPSQLGLDVCLILRLSGPLKEQYAKDHGLDYQELLNASFYKETHRAKMIKWGEDIREANPYFFCQKTVESAAPGVPVWIVSDARRLSDVIFFKEKYPNQLKLVRITASDDIRKKRGFIFTEGIDDAESECGLDKGLEWDITIDNSGDESLLDQNISTLVSLVQNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPP4</accession>
    <name>A0ABY7DPP4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_023451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF108">
        <property type="entry name" value="CLAUDIN FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ99078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="296" mass="32455" checksum="2F54BEACE0F447E4" modified="2025-10-08" version="1" fragment="single">MGLKRISESSVLFIIGATLVFVSFVLGIVGIATPVWTQSSTIKNGTSVEYHSGLWRVCSTIDRYHSMEETFCLSRIEASVEGWMQGVQTLEIVGLIFFVVGFVMTLALLLWSSNARLASANPWVLLVAEVNAGVPSVHNGTPGWFQAIQTLEIVSLIFFVVGFVMTSALLLWSSNARLARANPWILLIAGIFMEVGVIIFVVKLGMNNLGYSLYLTWIASNCVIVASIIIYCAEQRNRRPTEFTSGPTTSTPVFYPPPSNTNPVHISQPTYTPQPVAPVQPQPVQRSKPPYPGAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DR62</accession>
    <name>A0ABY7DR62_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MIEAP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_023759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026169">
        <property type="entry name" value="MIEAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771:SF0">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ99386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="278" mass="31309" checksum="CA0D15414E3BBF7B" modified="2025-10-08" version="1">MAESLRRLVNIGTFNVLQEKIERWNDNYYLNTCDQNVARGCEIIELNAKVQGQLFKLLSVCAQEGGLYGGTSAIKSRLLPFLGSSFFTSGATSDTTLSMLAEATAKNREIEEIKDMYEDSLAELESDIRARDLENQDLRDELAETKDQVSRSTRSASTDKLFLDNENRELRRKLIEAKDDLNRSLRNTSSDQIIGDMETREMRRKLAAAEEELRGLRAKAGILSDYDTQVRRLREDIGLLTGRRDALLRSSATMREELPSYRPATPSKAKSDDPGLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DS83</accession>
    <name>A0ABY7DS83_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ORCT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_024131</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ99758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="262" mass="29744" checksum="C4853BBB3CB09448" modified="2025-10-08" version="1">MSQHVDVDKIWISLGKWGSYQRRQLIVLLVAIWSCGFHMLSIVFIAYRPSFLCKAVDINESVVRGSNDTDYTRSYGKCSVTYMSNISGEASVEKSDCADGWYYYEDRLDLVCSRKELAELSQTLVMIGQGIGPFVFTSLADKYGRKPVHVLCHVALFIIVLCTAFVPNYPSFAAMRMLLGAVQEGTGLSLAILNLERFPKEICAYVGVFGLLFWTTGIAIVTPIAYIFRNMSWRYFQLCLACLSSWSLIEWWHTISYLLEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSX0</accession>
    <name>A0ABY7DSX0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052717">
        <property type="entry name" value="Vacuolar_transposase_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169:SF29">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="133"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="185" mass="21171" checksum="AA7E7EA48933B27D" modified="2025-10-08" version="1" fragment="single">MPERHTAENIASRLQECVREFGLTGKPCNNDTALVASMKTTFRDEMTERFQPGRDETAESLPMLASLLDPRYKKLSFLPRQLRRRTHTMLEGRLDDVPFKVSSRDDGDCATPAKRPRLEFMVTAPESSVEDDLQLYLAEKMDDATPALEWWRRNENRFPKVVQVARSVLAVPATSVPSERVNGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DT21</accession>
    <name>A0ABY7DT21_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46104:SF1">
        <property type="entry name" value="GENE 9195-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46104">
        <property type="entry name" value="GENE 9195-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="40"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="2012"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="2914"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2914" mass="303504" checksum="B6F6A11E210F3417" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DV90</accession>
    <name>A0ABY7DV90_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Shieldin complex subunit 2 first OB fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049507">
        <property type="entry name" value="SHLD2_OB1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21669">
        <property type="entry name" value="SHLD2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shieldin complex subunit 2 first OB fold" evidence="1">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="90" mass="10214" checksum="4085741C5174E726" modified="2025-10-08" version="1">MPHQRCRCYFSLQDSVATTVMVNDKEVNVRTITVEDRTGKVKVSLWRNIAAEPVVLGDVVAITNIVVNSKRYNNEESLSSTQFTKIEKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXB7</accession>
    <name>A0ABY7DXB7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FREM2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046133332" evidence="1">
        <location>
            <begin position="25"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="288" mass="31762" checksum="26AF3EA97BC4F0EE" modified="2025-10-08" version="1" fragment="single">MKDYSGDFVVTLLPCLLTFTQTSTQPISCSPSDNVTFSLPIRLQQVSDPVPSKFSLNTEFRVTRKSDVWLSEKLSYISEDDMTITPDVSPIQSLDRSVHLYIEKVFMCAGQRGYIPLYNPDIGHYGCVGKSEQLDTVIRILDIEDPSSVNATFQGVPLSAKMAHDDTQSSDVFNIPGADGFSFDSSPLFQTEDEKLWFLHIVFSQTATNGDVISRTSMFDSHTVRRSLDDIAGVGNGKKGTNMAPLILNFNGKSLKEDQYQPGKKTENSESQMPLIAALIGASVLLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DY34</accession>
    <name>A0ABY7DY34_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondria-eating protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Spermatogenesis-associated protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_024203</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MIEAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026169">
        <property type="entry name" value="MIEAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031981">
        <property type="entry name" value="MIEAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771:SF0">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16026">
        <property type="entry name" value="MIEAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondria-eating protein C-terminal" evidence="15">
        <location>
            <begin position="449"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="250"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="315"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAQ99830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="666" mass="77085" checksum="C47AD2A439B4585D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYI4</accession>
    <name>A0ABY7DYI4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046408213" evidence="1">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="74" mass="7717" checksum="F0D073FAB4D7E2BA" modified="2025-10-08" version="1" fragment="single">MASISKPVVSMYSLFLVICLTSVIKGQSGFVQPTGLSSANTASQFSTASNIIPNSNAFVQSANTFYPGDVHSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZB4</accession>
    <name>A0ABY7DZB4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LRP6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF41">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="LDL-receptor class B" evidence="1">
        <location>
            <begin position="56"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="1">
        <location>
            <begin position="101"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="1">
        <location>
            <begin position="138"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="1">
        <location>
            <begin position="300"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="1">
        <location>
            <begin position="343"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="1">
        <location>
            <begin position="386"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="1">
        <location>
            <begin position="430"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="1">
        <location>
            <begin position="599"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="1">
        <location>
            <begin position="661"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="1">
        <location>
            <begin position="704"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="774" mass="88775" checksum="318A4607B9EC7761" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZY8</accession>
    <name>A0ABY7DZY8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_009633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR03075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="141" mass="17046" checksum="4B74EBDB9D8719A8" modified="2025-10-08" version="1">MAFLIAPDRLRDLRIAELRWRLRRNERRQQFVLAVLLHEEEQRAQQQRRRWTVWVRSWLQRRVFLGQYDTLMNELRIEDRGGVISFLRMDVDIFFQILERVTPRITKCSKNRAPLSPGIKLAITLRFLATGISYQALEFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1I7</accession>
    <name>A0ABY7E1I7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RN167-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_009251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF15">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR02693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="79" mass="9214" checksum="794168C8270B4A96" modified="2025-10-08" version="1">MRLAETLGEVKDKGLTKGECCRLPVVSYRRTDSQEECNICMSEYEEGDPQKILPCFHSFHSVCIDQWICVVYFSMKWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1T3</accession>
    <name>A0ABY7E1T3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HIKES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_009474</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="100"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR02916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="160" mass="17896" checksum="689F703D6E501679" modified="2025-10-08" version="1">MFGIIVSGRLVQTNEEPVSENKVIFNIPDADNINHIVVFMTGQIPFPDGFGGADATSSNHPFGQMTAQTHLAQIGISVEPESQLAQQTPASIASTSAVEPFVEFSKKMCENVYNFMSSFALTQPQMTPNPTETFVPLSKLSQWYENFQRRLEQNPYFWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2W1</accession>
    <name>A0ABY7E2W1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR03549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="81" mass="9615" checksum="2133EF6956D7106A" modified="2025-10-08" version="1">MATTMESPTRPQVKMITTMESPTRHRVNMVSTMELKIITGFANSRRRTVMKFRRRWLSLLQWLLFTEVIDTGVKFRPTKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5L0</accession>
    <name>A0ABY7E5L0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RIT2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_010635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR04077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF6">
        <property type="entry name" value="RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR04077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="94" mass="10591" checksum="C82DA955F34AA57D" modified="2025-10-08" version="1" fragment="single">MQEMSSRFFDAFAVVYSVTDRSSYQAAVDILYHVCHQLVIQDKLAILIANKIDLTSLISVRLLPSAKGRSEAKQYNSKYCETSAALNHHVDELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6W1</accession>
    <name>A0ABY7E6W1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFSD6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_020044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="8">
        <location>
            <begin position="73"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR04675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="331" mass="36204" checksum="74EF1122BC35475A" modified="2025-10-08" version="1">MATSEVELSSISGMIADPLAAPPPTSLPATETSPIHNGNSVNSSSSVETKTPEQTCGNWLPLECLRCELKLSKFKSFFFFFGGAIGCVFPYFSIYYKQLGFGPNQIGVIAGVRPLIGFCSGPLWGSLADRFRVRRIMLCCSALGWLIFITSIGFVPPPTQSDSQCVYVAEFLGKPYNGSTPPTGQGDDLRDYFFGLHNNKPGVDPEESLFESRGWVYDRASLMKVYVIIMVLVVLGELVQSPCGALADSGCIETLGAAEMNKYGHQRAWGSLGLGVFSMLVGGVISETRREVSVCGEPVVYSDYRIAFYFFAGCMFCCFVTTLFFRFQDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E837</accession>
    <name>A0ABY7E837_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AMAL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_021554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045818943" evidence="4">
        <location>
            <begin position="19"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="30"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="140"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="228"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR06185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="366" mass="41092" checksum="F2EA666062CA6978" modified="2025-10-08" version="1">MIKIGSVFLLLYCYTAWGADPKVRLRQTFPETQLVYNYKTLVVEKDKDCYMACVVDNKPADKKVQWLIQNFMSNTTISISTDTDTQNAFKYQIDKPAANNWRLKIQNVQESDQALYICRVQLGGQQNANDSRMIQVIQKPQVVDIFTSSDTTQKEGDPLTLRCSASGIPTPMITWQMSGGGVLPTGGRELTSPVIVIPSVDRSYRGEYKCIAKNTAGVDVRRIYLVAPEVSVHQFRKEVYQAPGYSKELTCEAKGNPVPTQEQIIWYKEDQLLSDPNKYVMKSYFGSNYVLMKLRINDISDADYGMYTCHAENNEGGNENTVILSRSSSYVPEYEMFRASSGGMGVIALSVSTLLMFVATALLHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8H4</accession>
    <name>A0ABY7E8H4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897:SF2">
        <property type="entry name" value="OS03G0226600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897">
        <property type="entry name" value="OS10G0105400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="255"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="525" mass="59148" checksum="EA8EDCE0FDAE8256" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E973</accession>
    <name>A0ABY7E973_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HMCN2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_021098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF14">
        <property type="entry name" value="CELL ADHESION MOLECULE DSCAM2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="153"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="255"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="397"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR05729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="493" mass="54863" checksum="BE001B2590FE1DF4" modified="2025-10-08" version="1" fragment="single">MASYQIANTCDKYEDLCTIFNVKVKQSYIVTGIVEELAMIFLQAAKGILVGLSTLERSGHTAFDLGPIKNPTPSVCYENKLIFSFSCDKTAGDRGNISVACQVTAGVPNKTDFKWERHPFWVIIKNNVSSHGKAAGERRCTRTRQYICGLSVPPVVKPLANVVALERGNISVACQITAGVPNNTDFKWERIFDMIQVSMEQTLGIINIGRTQSGYYRCTASNLMEPTGYDATFGNNEAEVTNFTLSNSNHGQNFEVNENTKVIFYCQAKSNPLPNISLLKQSQYLKSATNTNDLEFTISESVCEDDGTYQCTAQNTHNTQADVRSLTLSATGVPAVLTLKLVAFPRPSVKDFLWEKKDLATNTWHIVADDTYIDIIISEDGLQTELFFRSVEEKDFGSYIVHVNNELGTYSETFRLLAQGFDGGLPQTFHVEYRDVETSVWRNDMVNTGKISHVIVGLSPNTIYEIRVYSTNDIGRSNVSNAIEVTTLKRPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAP9</accession>
    <name>A0ABY7EAP9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_017071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046447762" evidence="2">
        <location>
            <begin position="16"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR07113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="208" mass="24445" checksum="3BF07641A664F6F2" modified="2025-10-08" version="1">MKWIILCVIVAGAHAVCENENVEVCAFDPCQDLTCDVEEAQCQPGSCDPCEVTWMADSADVTAQCIAPLTKEQRKMKKKNHRRKFIQKKLGMRMEKRKQWKQMTPEEKQAAIEEKRENMIETWMNKGNEEKVERMREHWAGKIARMQERKEQVAAMTPEELKAFLEEKKARKMGQRKAFVIKKKEKLKARKHIKKQARQDKRRGEGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAX0</accession>
    <name>A0ABY7EAX0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HMCN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_021499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF158">
        <property type="entry name" value="V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 10-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="232"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="296"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="458"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="584"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR06130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="679" mass="73574" checksum="9B0F534CC1D5D3E4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EB22</accession>
    <name>A0ABY7EB22_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="183" mass="20698" checksum="DEBC9DAAC53096F8" modified="2025-10-08" version="1">MGRKNSFVAVKPSYNGQALRSQTTVPAQPLGKITHYTYRIEFQQRGSPHAHCVILVENAPKVSDPNEDNTEFIDTYITCNIRSEKDEPDLHKLVTTVQRHHHTATCKKKSTNCRFNYAKLPSPHTLIATPLESDDLAFKAATIDTVSSIFTNIYDTLEDNKISSLDELLQKTEISLEQYVYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EB33</accession>
    <name>A0ABY7EB33_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_017023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SYF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR07065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="232" mass="27346" checksum="6AC19E33118798BC" modified="2025-10-08" version="1">MASTSSDTCAPGSSGMDKTKSRLDRFKNLELKMNEARKMNHSEVVEEDRRKKLPANFEQKRKFVEWEEKEEAKRKEAQAKGEDYDRVKLLEITSEDADKWERKKKKKNPDPGFSDFESATHRQYQRNTKNMKPDMQEVARQKEKLGDAFYASKDTMGLTQHKDSKEAVDRMVDDLEKQIAKRAKYSRRRTHDEDADIDYINERNNKFNKKLERFYGTYTADIKQNLERGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECH0</accession>
    <name>A0ABY7ECH0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="131" mass="14915" checksum="FF2598C12583D4CE" modified="2025-10-08" version="1">MGFSFRENVIEKLCHKDLNMTPKDALLLFRFKATNNLLCETKNLNPPTSVLEFVPVFNTGTYITVVGLVKMEDVNLRVALVPFVSTYTSVKSDSSRGKTKQTPPRLFAILLLSLHRLLRKRHTLVERTGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDY3</accession>
    <name>A0ABY7EDY3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_021988</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="32"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="109"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR06619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="300" mass="32678" checksum="B9208215DDF4B683" modified="2025-10-08" version="1" fragment="single">PRGLSTLLWIFKNSYEGLYACEVDITLVTLRPKANPISVIENTPQLFQCLTSICRPKANVTWYLGSEQLTSATVSSPSQDVTASTLNYTSQQKHQNMNIYCQGSNGDGPSQIVCKLGGSTMSSAVSVKEGWEFRLDCSSDGNPSPSFSWALPGDGPTDTLFIRSINRTHTGRFRIIARSNLIPSEQQAVNLTKDIYVKVEVQYPPDPPSCRVGSTALSSNIVSAIRGNTITINCSCDSNPSSRYSWSVTGVSTPTSGQSFDLVVQKATTITLTMENSMQFTNGTTEQGRRDSPFDVRVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEN0</accession>
    <name>A0ABY7EEN0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KLH25-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_017547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR07589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="519" mass="58639" checksum="D7CF956B146AD2EA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EF14</accession>
    <name>A0ABY7EF14_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tesmin/TSO1-like CXC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22902" checksum="1E91AFFD7C06CEBC" modified="2025-10-08" version="1">MPMWFLMGTEVDRLQRTPTHDKRSKGQISARVCFNANTPCKTKKEVFLSNPINKQDLINIIGQNLTAYGFSVYHAEGDDGLLIVKTAITNSVVQVQSLPPTQSAAKYHSFRAYTQIQVWIGKEGVPLEWGWYRKDNKFVPVKCDYPTAPERLLKIIRCSCKGNCDTRRCTCRRHGLMCSMGCGECQGVSCSNSGTIADDEEVGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EH02</accession>
    <name>A0ABY7EH02_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="238" mass="27134" checksum="D59668A5B8157CF2" modified="2025-10-08" version="1">MKLSSTTWESQTPPITICLTERYPAISRFTDPGTCVILKRPLRQEKCQLPVQAEKGTLKQCLVVFAIITFCMSIAKIVVGAIYMDDCPYDKLISVWPIISGLIPLLYAPMLLRLRRETWPDTWEECREKDPNEGMGTADKVADFLAIIGLLVLIAWQIVGAVLVYPNRSKFNNATICSDTVTTNCIENCSTVLLNFGFGILTYEWSTFWMWCNVTGRILYRITKFYSEHKCSFVKNMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EH67</accession>
    <name>A0ABY7EH67_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_018413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd22823">
        <property type="entry name" value="Gal_Rha_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047076734" evidence="3">
        <location>
            <begin position="21"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR08455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="439" mass="48050" checksum="18C97F10F900FF3A" modified="2025-10-08" version="1">MYRQWIIIAIVLASAQDSSGLIGNACYGTNIACDFYSLQCPEGEIIHLNNLLAGGKSEPTCRSEQHCSGGLDCCSYSQGDLTSIFDLENTYHTYRNCSGRQSCAAIQAPWQRLDTQTFSSYVQIEYNCERVIPVTPMPSATTRRTTNAPRTTSGSAPLVKDSDDNDTKTKIYLAILVPIAAAIAFGVIFCMWLYWKRNNKRPLKLLHQKKQRTKSEIYRVFSNPKGDNVLEDIIKREHGLRTPSLHGSKPASVFGSDQPSFSHYVSGVPDPYEDAFVVGPSHAHANPIYEYVDDKKSPDGNGPYVIPLNVTEEKPDKLPEPQSNGIRPRTTYIKLKHARPSTKSNVPATSDLTDSTKDIADVYEPGETKGDLQNSANKIPGTPRPIVHTNPDGSVTVHIDNVSNPSVPNSARSTPGASSPVSSRTRSPERGGNGAVIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIU6</accession>
    <name>A0ABY7EIU6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SYAP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF6">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="173"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="364" mass="41185" checksum="D7549678E323629C" modified="2025-10-08" version="1">MFSSVSKWLGVVDNTVDEETLAVNAEGEEKPVEKPEIKDEEKTTATAEKVDNDPENDDLISPQTKQTLEDVSAKAISTAKEWGTFLYGIGKQASEKVTEKAKEITKSVEDKTFLGDFTKEQETFVTEKKEKDRKSEAAVPPWVGYNEEDDMKAQILALSQDKRNFLRNPPSGIQFQFDFDAIFPVAMATLQEDTNLQKMRFELVPKQIKEDMFWRNYFYRVSLIKQSTQLTSLAQQAGNGEGKDHSRSSSISSENKERSSPKPVQRSPEVEEQAGSPQENEFVSDSFADDGQISDEDLRKEMEMLGMEGDKKEEGEPKENPTVWEAELQRELQEYEMVGSGEDIDDADIENEILKQIEEESSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELR8</accession>
    <name>A0ABY7ELR8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LRRD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_035030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056869">
        <property type="entry name" value="DD_LRRD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24978">
        <property type="entry name" value="Death_Lrrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Death" evidence="4">
        <location>
            <begin position="685"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR09954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="763" mass="87111" checksum="55F996DA7BA05C6F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EN98</accession>
    <name>A0ABY7EN98_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_035282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR10206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="334" mass="37444" checksum="5645E5972A212568" modified="2025-10-08" version="1">MLDDTLSGFLYTLVTGVALVTFLVSSFLLYHWRAVQRRRRELEYRKYWEALRPDLAARRNAGYRTRCHPAFRPALPLDAQAKELQVVVKTRSGSFHIDTERPETPFTHPRPGPIMQSGSRVPSITGSEADQYNKSSNKTHCTRCHAYLQTEDPPNDVSFHARDTPNPSIDSEDTTEQETSIDSNEKQYVASSRSYDDLCNSYYEERGATPPGPRMSYGVTGAHRMRSFSVDTMLKDFCGDLQVAGRRRNSFFRRVNRGAGTCLKRPPSMLALAADTCRLTSVRILNKSIPGGLIRFWNSCAGGMSALSEGTCARTEGSLDRGAPPRGEDYKNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7END8</accession>
    <name>A0ABY7END8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_035796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045661962" evidence="2">
        <location>
            <begin position="23"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR10720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="178" mass="17410" checksum="EDF222A387257E52" modified="2025-10-08" version="1">MDFRGFTACAIIALCLIKQSDADPITAWAETGGNSATITGASGSMTVATVTDNIAAGGTLFTVTATPASATYAFDANGNPGGLAAIAAATGVVTIIAALDITTGKPTNFGVSAGAVTTAVAMSASTKAGYAITVTATDANGKTSVANIWIVVGICSGAMKITVTAALVLMSFVSAYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENT0</accession>
    <name>A0ABY7ENT0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NOP58-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_035961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nop" evidence="2">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR10885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="234" mass="26275" checksum="2F0513FC25694BB6" modified="2025-10-08" version="1" fragment="single">MSKSLKSLMKKVVASDAHDELAVADAKLGNVIKEKFNLSCVANSSVQELMRGIRNQMDSLITLPTKEMSAMALGLAHSLSRYKLKFSPDKVDTMIVQAISLLDDLDKELNNYVMRAREWYGWHFPELGKIVQDNLAFAKVVKQMGFRTNAVNTDFSKILPEEVEKDVKDAAEISMGTEISDEDILNVTYLCDQVIEITEYRAQLYDYIKNRMVAIAPNLTVLVGELVGARLISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESF3</accession>
    <name>A0ABY7ESF3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="214" mass="25080" checksum="616A1F5F4C866BE4" modified="2025-10-08" version="1">MKNVLIKCYIIGHTLSFGNEKQAVLQFHCMAHVLLGFKRNVAEDLKRFRTEQIVYPALGIFGPTADHLGIIDRQESVIWEDYCVDNGTASEVFLHSKHLLKVIKTVQSRKQKILPVEADYITGPYWLKRNTVRQCMYYTEISDIDVHQSHWSILVEAEYRQCMSYTEISDIDVHQSHWSILVEAEYRQCMYYTEKSDIDVHQCHWSILVEADYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ET39</accession>
    <name>A0ABY7ET39_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="31" mass="3465" checksum="BD0953C12C153669" modified="2025-10-08" version="1">MNRKFGAACGDWTPNTGNHSISRCILLCQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ET83</accession>
    <name>A0ABY7ET83_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="16400" checksum="74E528E44A8C61B2" modified="2025-10-08" version="1">MGKIKLMMKINVQKNETKNLKSEVKKVEGQTLSEVVESFELCDLMATCDTKRFKTFWQQWKKSTSKNNGIRWHPMIIRWCLYLQHTSNKSYKALRQSGFIKMPSSHTLFDNSHFTKSTNGITAETVKLLKERNGKKMDHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUF6</accession>
    <name>A0ABY7EUF6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CPMD8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_026353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF146">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="2">
        <location>
            <begin position="371"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="3">
        <location>
            <begin position="1170"/>
            <end position="1251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR12173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1293" mass="147435" checksum="40799D3AFD3182AB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUX0</accession>
    <name>A0ABY7EUX0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_026696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR12516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="398" mass="45739" checksum="A3CAAE573D3D6D9F" modified="2025-10-08" version="1" fragment="single">SAEEVCELFKTELQFLESCLRGNPKSYGVWNHRCFVMDTMAEPDWKKELQLCNLFLERFVVERSNVPPKAELEFTQSKICNNFSNFSSWHYRSKLLPLIYPDDSTAVGVEENVLIKEYEAVQNAFFTDPDDQSKKKPGVSCMFVSRDHQSLMINTTQPVLDGSPWLPGKDEVEVQVAADAEDWGSSDSVQLQAGQPESWTLTQDDQGLRFRHELSAATTDTLQRELQSIQELYDLEPENKWVLLTIVSLMKALDPLKYSEQIETFISQLKTIDSTRLHYYEDLRSRYILENYLEEFDFDQRVVSLASRSLTCLQCAREVILDDNKIEEVEELRYLKDLSQLSLKNNSIPSIDVLDPLVNCHHLIKLHVSGNPMSELSSHTDVKHLLPSLHNVDGHIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EV70</accession>
    <name>A0ABY7EV70_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="559" mass="65354" checksum="3ACA12D9E0002B04" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EW96</accession>
    <name>A0ABY7EW96_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TYR1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_027404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046211615" evidence="3">
        <location>
            <begin position="21"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR13224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="761" mass="85685" checksum="431DC5E01718237E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EX71</accession>
    <name>A0ABY7EX71_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050996">
        <property type="entry name" value="Docking_Protein_DOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258">
        <property type="entry name" value="DOCKING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258:SF62">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="51"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1050" mass="117380" checksum="8FB2FE90E55D83F7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EY27</accession>
    <name>A0ABY7EY27_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047234191" evidence="1">
        <location>
            <begin position="29"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="103" mass="12084" checksum="2B4C4EDC808CA6FF" modified="2025-10-08" version="1">MVLPRIWNLWGYCRMLVLLLVFCYIVSADDQFLCCMAGIKKVRHISICPAPCCHGYEEHSVYTAMMAQISFCRKLEEDTSQELTTAVREKWGARRYPDKLFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EYP7</accession>
    <name>A0ABY7EYP7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF1">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="362" mass="40663" checksum="F4D08311F6899CE7" modified="2025-10-08" version="1" fragment="single">NSYFYGHAGLRHLLSESGVYAAGTVNDILTGKDFDRALTAFKMIDEALNSRLLTNFEAWCIENDIDLDEDLEEMLKAFVSERLIAKPDGSDPPVKGFFSPMTRSKVKTMATSKIKTQVKRTNNINSEVMFQRLLAVNAYKKVSTERVFAFENTPVPTSLFSEDGTMLKCKKSDFMTMLEGLLPDKITHIHKADTLIFDGMALVQSLSPQSEHLTFRYMAEMFMKHVFKKASNIANVKTVHIVFDRYSNISLKTQTRNGRGDSSTKKALHIHGDLAIPKDWKGFLSVGKNKERLIAYYTDYIVQNSAPVLKGGESLFISGGAEDKCFLLTDGSCEEIKDLRSNHEEADTRIIIHSAYAKKKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZI5</accession>
    <name>A0ABY7EZI5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PBURS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034441">
        <property type="entry name" value="Bursicon_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41151">
        <property type="entry name" value="PARTNER OF BURSICON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41151:SF1">
        <property type="entry name" value="PARTNER OF BURSICON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045661963" evidence="2">
        <location>
            <begin position="23"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR14251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="346" mass="39388" checksum="F29D0AFAA9DADF2E" modified="2025-10-08" version="1">MALLLPVLFVIVFHHAILITSAHTFGQSRFGQIDTRSDTLRHKSGTDESSEEYLENILKTPVLHRVKFSVPVPDGSDPNLGLYQTSDDVSSKAISHKYMENMFLYNLLMSRALLRPMNYNFSPGKYGYPIDSILTGGKYSYAKRDDIETDGIKVTPPYPIEKNNRYNNRININDGKSQTFRSHRFVKRASENKLDKSRNSSDNVNASSEINNKPHNADELKYSSDILPPPQKRPSGDVEQCKMETVEMDMRFRQYIDTHNGPLLLTCTGRVTINKCEGLCRSLVRPDVTAYDGFERSCNCCKDVSRRRTPVTFSICDINSNEVFGYDITRDITEPTECACLECSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZZ8</accession>
    <name>A0ABY7EZZ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="82" mass="9420" checksum="704F7E0C63D9AC36" modified="2025-10-08" version="1">MKRAVNVSAGGIWHYESQQMGVVSRNHNRKFFCKYCIQYSTEERILKDHTDICLAINGGGGKRVSFQLKERIYLGLKIIISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0U2</accession>
    <name>A0ABY7F0U2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MELT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_005074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MELT/VEPH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039888">
        <property type="entry name" value="Melted-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21630:SF10">
        <property type="entry name" value="VENTRICULAR ZONE-EXPRESSED PH DOMAIN-CONTAINING PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21630">
        <property type="entry name" value="VEPH-A/MELTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="376"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR14969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="504" mass="57348" checksum="06F9468D8E30FDB3" modified="2025-10-08" version="1">MDGRNRNTGSGPKEVRSVSSQTEGTVTIITVGNSAYPSNVVGVRQQQQQQQQQQQVPHSNRSSQLSLTPSSRMSIANSRSLSDRPPEPFRDGVQHFCEKHMDTIRKFISSLSAMIPLPAKCSIVDGRHKRYVRLNFQCGIKGTNCLYGKQFFILNTKLPKTWIHLMFLAVQLSLKKEFYPCVYIHLGSNDVQAREDVFYRRVTEVCDSIHETSPETEIVLCSILPRKKNDRRVSSTLARVFNRWIQNANTMLMDISEAIPYIRFLGYGAQKSTKSSRNQPNSKSTISTSSLNPVEKTSPPNQDELDIADHADFSKLKLLLSNDVEQNPGPDQDALLQELHGDRYFDVFDFNAPRKYWACFMCNHPKKMSELMPDGSPVIAGQLKEKKGRWKFLKRWKTRYFTLSGSQITYSKSDSRKETLPVREIQSVKAVRKGIRDIPKAFEIFTTDQNDVFKAKGQQNIEPWVQCIHLAVPKAQNDGECTVVENVTITIPTRPRSAVRDTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0X8</accession>
    <name>A0ABY7F0X8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA repair protein REV1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_004836</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19318">
        <property type="entry name" value="Rev1_UBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012112">
        <property type="entry name" value="REV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047346">
        <property type="entry name" value="Rev1_UBM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036573">
        <property type="entry name" value="REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="9">
        <location>
            <begin position="353"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="203"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="657"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="970"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1027"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1140"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="685"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="751"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="791"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1038"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1080"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1185"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1212"/>
            <end position="1225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR14731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1385" mass="151744" checksum="873B9DEEA933303E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2Y4</accession>
    <name>A0ABY7F2Y4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045779723" evidence="1">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="82" mass="9159" checksum="EC87B8CEF0D50CEF" modified="2025-10-08" version="1">MEIENLLLLFILVNSYCLGINAQVSDGQSKGDRDNERGLRDIAPVANDIDNTTKMHGNEERLSSKIYYSSPANLVIHTFCCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F615</accession>
    <name>A0ABY7F615_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR17042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="78" mass="9034" checksum="E2FC77FAAA649B92" modified="2025-10-08" version="1" fragment="single">MPRRHQSAESPVPEMSSGLLAHCDTRVLRVRNQRCTKDVWWSFGTRLHQSAESQVPEMSGGLLVHCDTRVLRVRYQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9B5</accession>
    <name>A0ABY7F9B5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRADD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_032348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037939">
        <property type="entry name" value="CRADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15034">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN CRADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15034:SF5">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN CRADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00114">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="481"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR17754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="641" mass="74489" checksum="B611D39C21EDA6D7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCR1</accession>
    <name>A0ABY7FCR1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CASP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_001007</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052039">
        <property type="entry name" value="Caspase-related_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576:SF41">
        <property type="entry name" value="CASPASE 14, APOPTOSIS-RELATED CYSTEINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576">
        <property type="entry name" value="MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="4">
        <location>
            <begin position="163"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="3">
        <location>
            <begin position="316"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR19169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="400" mass="44101" checksum="26914BD1C7A4C9D2" modified="2025-10-08" version="1">MAEGIAILVVNEKENICSNNASKAPFKDRNIFEFDHDLLTSIFNTRLGFECVYLKDDHENTEEFNNNQEDGEDTQENLTAHADDKTVNVDEKTESTENIKTKEKGTNGEDSIVLALEASLNSGENNAYLNKDLSNDDLAHSTGIQDPKECGCLQCKVRVKAGNSESKYFLCAISSHGEEIDGQMSIQFSDGQFFPLNDIIEKFSDKACPELKGKIKIFLIQACRKDPHVKLEAYKDQGVKIQCANSGAAGAKQASGGHIDMEDSPETGQIAIAAGRIPRNTLLIFSCWSGRPSYRTVDKRSADCIVMAGEDEEIDGSWMIREMKKVIDKEKGTINFLSTLTKVAAAVAERETGDGCKSTMTIIHTLTQPIYFKLRNPGDSDDEPGDSDDELKLDKANINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FE12</accession>
    <name>A0ABY7FE12_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_002233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR20395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="245" mass="28784" checksum="AAC6CA94B7B97E48" modified="2025-10-08" version="1" fragment="single">DFSRDLERRYQSEQERIEQARTELEQLKSEHERAEEARQLREEEMYAAHEQHRADIEDQKHQLLRLVEENERAREKAKEELQLAREIQKHLDGERQKLREQQKLEQQQQQQGSQGSISIQTDPLCTTTTCVGSDDGLSSGHKEMGVGPNPGVDEEDGLILAKDVTVFREGRKVSTKEQLAELDQEEFSRRMSYRETEESLAFQQEDIEDSYGQTQQQIQARIRKIQEMEEEYKELDKAHLQDITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEF8</accession>
    <name>A0ABY7FEF8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEPH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="219" mass="25128" checksum="9DACDFBBC6B8CE89" modified="2025-10-08" version="1" fragment="single">AADIHLRRGPQRIGSRYKKAVFREYTDSTFTVRKLRSKYQTHYGLAGPPVVGEVGDIIEVVVTNLATRPYSFLADPRRSGAIVPIGAVRVYKFDVLQNSAPTHIDPDCLTYPYHSAVDVQKDIYSGLFGPMVICKPGTLTKSGTQKLFDREFFLNWMVIDENLSWYIDENIQTFTTMPWTVNKKDRSFVSSNQMRELQTKLTYYDIQMVDKDIKVKNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFE2</accession>
    <name>A0ABY7FFE2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_001545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF116">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045976064" description="C1q domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="6">
        <location>
            <begin position="68"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR19707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="203" mass="23214" checksum="2BD2A5D5C9FFAFD5" modified="2025-10-08" version="1">MHCISLIFVSCFLNVALVQSAEEDYVRPETFEERLGRLEELVDIQSQTIAELKQDNTNLRDTILNSTLADEQVAFYAYLSQGKCYNVHETFIFDIEELDTTNSYANHDGVFIAPVNGVYAFSFNVVPDFWHYTQAELVVNGQVKARVFGDSHEIHDIHPTSSTVVLALNINDHVYVRLGHQTECNVISSEDHQWTYFAGWLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGX4</accession>
    <name>A0ABY7FGX4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="335" mass="38711" checksum="90798535F4F9812C" modified="2025-10-08" version="1" fragment="single">MENPPDFYRIMSLRLSRALSDIGVNRWMVRRRRRTFLMLEASETIFNKLQGRDFTSFYFGSQSEGTTTPGLNSDIDTLTCINIINIMSSWSEWEAGRRNMLMVKEETCSPQHYLLQVIRPDSPEPLILPETSDFMPEDMISFYGLYLKTVRTYVHELPFPLRVQYFDYVFRQVLSVFASTAASCCIRNGSVVPRNILCLFESSLDTDVASSRLKLASFLVCHNELERAADVLNDVERRYDDSVQAVCACNRMDPLDTEHHKPLCTTSVVNNDDVLLTNKTALCVRYLRQEAFCAPPILHYEMVRGIGEDINHRNSNERGWMNWAVVDSLPYLYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHC7</accession>
    <name>A0ABY7FHC7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SL172-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_015557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="27"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR21583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="410" mass="45070" checksum="C7F4C434006EB6DC" modified="2025-10-08" version="1">MERSDQYDVSTDEKGFDPDKVPWWTSSRLALAVLGFFGFLNVYALRVNMSVAVVCMVNHTAISMKEMTTNSSGNLSTTIVASSSSSHCGLISTGSENKTDSDADMDGEFVWDKKVQGIILGSFFWGYLFTQIPGGWLATKIGGKRVYGYCMLGATIATFLTPIGAQTHYIFLIALRVIVGFTSGVCYPSMHALWGNWAPPLERSKLVSFTYAGAQVGNVITFPLAGVLCKYGFAGGWPSIFYVLGIISSIWFVLWMIFVSDSPSEHKRISKEEKAYILYTLRDSAKREDNKLSSMLVPAVLLIGLGYVDCSQPGIAITLLVLGVSLSGAQYSAFYVFGAIFYAIFASGTVQPWARKEIEEALDAEVELLQVNKTNGKVNHEENGDATKVTDPMDFCLQRYCIYCIVDTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKJ9</accession>
    <name>A0ABY7FKJ9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AQP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_015843</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR21869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="269" mass="28993" checksum="28B668958EA23697" modified="2025-10-08" version="1">MSPIDGYFLYLASRLDKLRRGENTETGNWLQELKTWSLWRAVLAEFLATLLFVFIGTMSAVDIVPITDSAGKFIRIGLTFGLMIAVCIQMFGHVSGGHMNPAVSLAMAVSMDISPARALLYTVAQCCGGMLGSLLLKSVTPGELNDNLGLTTINPDLNGVQAVVCELVFTFILVMSIFGCTDPNRALLGSPALGIGLTVSVLHFASIPFTGASMNPARSLASSVVSNNFDLHWVYWVGPVVGVESNDVIVVPKNHFDEKGKVIVESYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLI5</accession>
    <name>A0ABY7FLI5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGD6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="116" mass="13179" checksum="76A16A909A52D36A" modified="2025-10-08" version="1" fragment="single">NERLKTGNWDCLDTALLKWFSNAHERSVVISGEVLKIWAAESAHKITVFNTTSDWLDQIQERCGIHFRSVYGESNSANNKAIKDGDIKPKSMLQNYSADDIYNANETGLFLRMLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLT7</accession>
    <name>A0ABY7FLT7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17466" checksum="ACFC780D2A2BE0BE" modified="2025-10-08" version="1">MLATRLHRLAFFKKTEKSSKVSRSLLIQWHRRFSDGWESVADDKLPGRPAVVGANVEMVRQIVMEDRRKTYLKLLREPTLDIAGIRRNLVRAFLKKRPGTDKESMIIQQDNAPPLRAHETLMTIDFIGLERIIHSPYSPDIAQWTLLSFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLZ6</accession>
    <name>A0ABY7FLZ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="124" mass="14179" checksum="6233CBF80CC5C57F" modified="2025-10-08" version="1">MPANLNTKSLKQFCLRKIALCFDSFWMKSFNEQFKDVPRILYVIGPFDHMTNETVQDLINSLIDVNRLKAVHFQLLLQESVVRLDLSKAPKPAVSDSVLKVIALRCPMMKGSRAFKKTDYAMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMQ6</accession>
    <name>A0ABY7FMQ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LIPI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_036531</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF181">
        <property type="entry name" value="INACTIVE PANCREATIC LIPASE-RELATED PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR22862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="131" mass="14047" checksum="4547DCB28D44FE07" modified="2025-10-08" version="1">MTIYPVHCWSGFGLEQPVADVDYFPNGGEKQPGCPNEIGKHLFSLITGKIGALVDGVACSHMRVLDLFIESINSPCHFRSYPCASLADYKAGRCTSCGAGCANMGFDSNTGHPHHGTYYLSTHGATPYCAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMY6</accession>
    <name>A0ABY7FMY6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BETA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_037084</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR23415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="718" mass="79687" checksum="226DF569AF4BB3EE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FN93</accession>
    <name>A0ABY7FN93_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="279" mass="32527" checksum="930DE6BA62B824B6" modified="2025-10-08" version="1" fragment="single">MASEEYSDNRQMDGLQPDLCRKTPVTHDRLRKDLEYAQQEIERNVYDELDDSSISTRDSNQIDAIPGFADDRTKPCKHTFKDPDYAYIKGIMRGTGDHGLMICIPKEVISKFVKQEDGKHIHVRSLIGVCQLVNVQVEEDLPENRVWVEMTAKRKPTEHQYSSTLSMGTVQSAQYARGQIYRTENEPTRRSPVQHSDDNKDDYQTLKFEYVAPAGSIIVDDILKHQKVADFLLDKTNDFDLKLTQWEYDYEAPVLLERFLWYHKDIDHREAKQRLNGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPH0</accession>
    <name>A0ABY7FPH0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TX1B3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_037799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd10822">
        <property type="entry name" value="PDZ_TAX1BP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF51">
        <property type="entry name" value="DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR24130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="151" mass="16877" checksum="1EA51A0E1C15E9C1" modified="2025-10-08" version="1">MAGHNAGDPLECFSIPIVLHKDLDRDDAGNPMIGPDGKQRYRCGFRIGGGIDQDNSKSPQGYPDKGVYVTYIHDSGPAARCGLQVHDKLLQVNGHDFTVVTHKKAVEYIQRKPVLNMLVYRRGVPDLQRQDGQQTQFQSYSQQAQEYPIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPZ8</accession>
    <name>A0ABY7FPZ8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Tartrate-resistant acid phosphatase type 5</fullName>
            <ecNumber evidence="2 6">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_037957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2 6"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd07378">
        <property type="entry name" value="MPP_ACP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024927">
        <property type="entry name" value="Acid_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000898">
        <property type="entry name" value="Acid_Ptase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045583568" description="Tartrate-resistant acid phosphatase type 5" evidence="7">
        <location>
            <begin position="18"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR24288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="316" mass="35501" checksum="158F6441E2A7F9B0" modified="2025-10-08" version="1">MVDRLVIILFLLHGASCLDSLRFLAVGDWGGLPTFPYETPVELAVAKQMADVTNTYHTSFNLALGDNFYFDGVKDVDDKRFKETFEHVFHYESLMNPWYLVAGNHDHNGNVSAQIAYSNRNFPDYYYALSFKIPGGGVVDIVMIDTVLLCGNTDDDVVGDQPHGPSNARVSDDQWSWIDLQLQSSKADFLLVAGHFPVYSIAEHGPTDCLIDRLKPMLYKYGVTAYLSGHDHNLQHINSQENGKTVDYFVTGAGNFVDASEAHKSDIPSGTLKYHWAEIKELGGFSYLEVTPNNMTMTFVNGRRTPLYTYTLFPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQ87</accession>
    <name>A0ABY7FQ87_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MEGF6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_036552</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047273413" evidence="8">
        <location>
            <begin position="21"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="9">
        <location>
            <begin position="186"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR22883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="576" mass="61159" checksum="7C22945E0EAF804E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRQ8</accession>
    <name>A0ABY7FRQ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGRL2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_038579</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF347">
        <property type="entry name" value="FI21270P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="8">
        <location>
            <begin position="146"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="394"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR24910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="595" mass="66443" checksum="4B36498A38629048" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSB3</accession>
    <name>A0ABY7FSB3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CPT2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_010824</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF16">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="5">
        <location>
            <begin position="65"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR25120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="637" mass="72960" checksum="B962E565F60C060D" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSJ4</accession>
    <name>A0ABY7FSJ4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTBDJ-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_037923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd18494">
        <property type="entry name" value="BACK_BTBD19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18294">
        <property type="entry name" value="BTB_POZ_BTBD19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042846">
        <property type="entry name" value="BTBD19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46965">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46965:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="9"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR24254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="257" mass="29231" checksum="2C00E4C90FD397D4" modified="2025-10-08" version="1">MANEKLMKGDVMEFASNMKKLKPVYAHRCILSSRCAVFKATFAEQTQKNGTIDKDTPFVLSDMSADIFMAMLEFIYTNCVTLTPKIAIEVLATALEYGLDDLRRAAVTYGQEDLKEKVLIYIEQHTESVFKSKAFQELSEDALAEVLKIDGLGMDEAEIIKYVKEWAAVNSVVLGRPVADVAKNVIVWIRLPILTPDEIEKLEKDNKKDNIIPVELFSTAWRFHALNQPDPNNERARKRIGTQERSHHKNLNVHKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FV16</accession>
    <name>A0ABY7FV16_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_038245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR24576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="410" mass="46293" checksum="02BDA58C8262BC20" modified="2025-10-08" version="1">MLHFPKHICCQCHLNIQAGLDETRVTLALEPEAASIWCETLDVDTRAALAGTGTQYIVIDLGGGTADISIHEKKRDGTLKEIHQPSGGPWGGIYVDANYLKFLEHIFGEKAISALKTEEMADYFDVIREFETKKRTYSKQTKGKFTFKISATTRRLSEKFTRQNLENRICSLGYGDSVIVKGGDKLRVEPDIVRTWFDGPINNLVGHLKNLFTEPKLRAVQTVVLVGGFGESTYVQERLRDEIPDKRLIVPAEAGLTVLKGAVRFGHNPTSRVMKYTYGAMVNMIYNEKIHREDKIYVDEDGDLLVPECFDVFVRVNEDVPIDHQSTHRYIPLAYTVCTPIYRTTAEYPVYVTEPGCELLGKLVIELPREIPLSELGNDTTFMFGGTELVVKKRVRKTGKEQILKLNCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWF4</accession>
    <name>A0ABY7FWF4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PXDN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_012229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF4">
        <property type="entry name" value="CHORION PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="671"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR26525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="739" mass="82457" checksum="FDDDCF9127076DB0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWQ8</accession>
    <name>A0ABY7FWQ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BABA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_037275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd21502">
        <property type="entry name" value="vWA_BABAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026126">
        <property type="entry name" value="BABAM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15660">
        <property type="entry name" value="BRISC AND BRCA1-A COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15660:SF1">
        <property type="entry name" value="BRISC AND BRCA1-A COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR23606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="339" mass="38132" checksum="F9061FE211ABFF7A" modified="2025-10-08" version="1">MPNIVSFVEAVTLNCSLVHNVYNVFQVDTLPEYGYVSWQVFVTLKGQYDNACTSASNSARNVLGYRLKIKMEANRPQTPEISAKMVNSKHSSRHSSNVLDEYDIIHDDAVKTNASGGKSTTGLTEPPEVPPRQKDPLQTHSQISSRNRLSSSEKSSTDVDSHTNISRCPNINSKEKIIFCVDISQEIEAPRFRSRVGEKKDAKSLIRSGLNIFMQSKLRLDKKHEFALVLLHEKATLKFSPPPPVEDDIERTIPEFTSFNELNSSPYFFIDALYLHEPEVFDSICDLDQKGLSYIFGASRNLTKVYDTMGQMLAHPLQRPVQSETMYRIGSSLPVPENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXL1</accession>
    <name>A0ABY7FXL1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PZR3B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_011313</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF157">
        <property type="entry name" value="RECEPTOR-ASSOCIATED FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="241"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="159"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR25609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="291" mass="32650" checksum="1EB9C69103464906" modified="2025-10-08" version="1">MGFDTEKFVCYVSEDRKCSLCNLVLDNPVQGPCKHVFCSGCILPWVVEHGCCPFRCQALNTGNLTNVLALRDLVLNMKVVCEFRLNGCTEQPKLREFIPHIKECAYRKVRCGNEGCDRLVCAKDLEAHEIQDCGFRPVGVCESGCGAVLKKNDCEHDCIQYLKSEVLNQQTRVQNIEKELKLLNDQLKTREKELLLRIKGMKKRLQFQGIKLVNQEKNPETMPVDNSMECTTKPEPNNNGNVIISPNNSNNNNQHVGMATEGIIVSKVLAGGPAQKKGLQTHDQIVKYGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FY16</accession>
    <name>A0ABY7FY16_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="507" mass="58381" checksum="90B3C9960880B2E3" modified="2025-10-08" version="1">MVRNVIADAGIMGRYVTDGAALSAHNVTESVAFMGRYVPEDVTYNNICCIIQVAILQIHQMAEFIHIKVSVSHIYSLAEVVQTGGRFVHSPNGRGHTNNWQFRTFVRWSGQTPRWPFRTYTRWPRSNKKMAAQHIHQGNKQNMLFVNSDVYAQLRPRNVDRKERHPGARERNSNKRQRLQDKRKIPPENAPRSRATEPQFHPTYSHDSAVKDFGRHETCSEQNEQQKVTSYYQELSTIEAIRKSIDKTSRAKSAPSANIPNWMLTLDINLDVSSVDIIPPYDDGVTLKSRASETFSERASLTFVENNSEDNIDNLSDSKKDYLEAVPNENENIHQEKAKSVPIPNNKKREVYADTSVWPKQNKSARPLSNTFRIATPFSAGWTNTEDTGPRRYQGDKKVMSMQQGGIRSTPMQPKSKKYINQMLTFHHMKHHEKKIRLAKHRKRLVDQRISDSWSMSSNTPTPMTQRRFHNDKNVTSSDSQNVTTRRNVSNEDTSETKQTKYVVKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZW7</accession>
    <name>A0ABY7FZW7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="92" mass="10285" checksum="9B14ED19017993A3" modified="2025-10-08" version="1">MHVLITRFKRIHGFEEHPATAPPCPNPSAKPTPPLIPSLVQKKCYFSLTSNAHATFVDVILWFLGKRSTKMRPQSSSPLTFNPRSEIVSVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZZ9</accession>
    <name>A0ABY7FZZ9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="85" mass="9453" checksum="6274A7C2CE305EB8" modified="2025-10-08" version="1">MRQTDSIMQVDSWQHVGSFALSNKEMLERGVLTDVTIVAGSSGERLNYLYCGQCSINNETVMALMYAANKKNVYDDLTLFPPTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G120</accession>
    <name>A0ABY7G120_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="183" mass="20439" checksum="4C8F6892F45A7AD7" modified="2025-10-08" version="1">MDATFNLTMAGIKTQTSMFSLESATVDKGACKCQEYLQTTPSISLMMFPSGDILQVRFPESTFQPFHAEKVSMSPFFFMNPHKHFKTSGGPNITELTTGDIPIGDRGNSYTCMSSQNVPYERNQPYHMTMTITNLHVQAYDIQEGKLSPATTCSTDMSTVRPVPTVCITNHNKDCFRKIKKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1Q2</accession>
    <name>A0ABY7G1Q2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR27053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="69" mass="7653" checksum="3B6596BCE8A88E0A" modified="2025-10-08" version="1">MPQSKSKRRRKKGKSGTTEGNMSGAVMGETKPLTDSHEAEGTHSTSGTFDDEYALSSFRDKKNSRDRQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2D2</accession>
    <name>A0ABY7G2D2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF885 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361:SF2">
        <property type="entry name" value="DUF885 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="GLR0591 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="73091" checksum="8E21F744A9D0B8E5" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G381</accession>
    <name>A0ABY7G381_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DRD2A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_014631</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF125">
        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="46"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR28927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="495" mass="55514" checksum="3EE87F474B228DDD" modified="2025-10-08" version="1">MANVDTPISESGTMNLTLYDRLLPPGASYNWGVLLLGFVVVFGITGNVLVCLAISLEKRLQTVTNYFLLSLAVTDLLVCILVMPMSILNEFFGYWRFTAQACNVYITTDVLMCTSSILHLCSISVQRYLAIRSPLKTRNKSKSVVVAKIGVIWVAAVAISSPVTVLGALDQSNIFNNHQCLLNNDGFIIYGSILAFFIPLIIMVITYTLTVRLLRKQSKLCDPNSQDAKEGKPIIRRCKTSVRRHNSLSDCRLVNKDCYELFEKEKINNNSNPGHIYKQIPSIIPHSVSCESLYTANVTRKTFNVKEPSKSCFLDVPRLYTVNNSTETLTSSDIDISEEEESFSKFHVHDCSRKSSLTRTFIVKASSLLSLARYKHDKTTVRTEQKASKVLGLVFVIFVMLWLPFFIVNIIPALCDACPVNPTLVSTCAWLGWASSTINPIIYTTFNKTFKRAFIKLLTCKYHTTAESTCPLSKDVRKSNVIIRENSSDRELTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3D2</accession>
    <name>A0ABY7G3D2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SCUB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_014116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052235">
        <property type="entry name" value="Nephronectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050:SF27">
        <property type="entry name" value="FIBRILLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="82"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR28412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="635" mass="70766" checksum="7C079570D66869E6" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G647</accession>
    <name>A0ABY7G647_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECT2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_014543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026817">
        <property type="entry name" value="Ect2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049395">
        <property type="entry name" value="ECT2_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16777">
        <property type="entry name" value="PROTEIN ECT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16777:SF2">
        <property type="entry name" value="PROTEIN ECT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21242">
        <property type="entry name" value="ECT2_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="1">
        <location>
            <begin position="178"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="569" mass="64233" checksum="47DE2573DB83A3B6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G665</accession>
    <name>A0ABY7G665_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FUND1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_014558</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF0">
        <property type="entry name" value="RE45833P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR28854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="140" mass="15455" checksum="48211B3A38FD0294" modified="2025-10-08" version="1">MAGERVREVYDEIIDMAAFRRNKSTWEKALGDLTKKSAVQQVAIGGGAGWVSGYLFVKVGKIAAVSLGTSLLLLQIAQHQGYIQINWNRVNRHVEQARRKVEREAARKCPGIVDNVKTFVQQNVFLAGSFAGGFFIGLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6E2</accession>
    <name>A0ABY7G6E2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="890" mass="101779" checksum="332818B70290A42F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7U1</accession>
    <name>A0ABY7G7U1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CCN4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_033029</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050941">
        <property type="entry name" value="CCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000867">
        <property type="entry name" value="IGFBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017891">
        <property type="entry name" value="Insulin_GF-bd_Cys-rich_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11348:SF17">
        <property type="entry name" value="CCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11348">
        <property type="entry name" value="CONNECTIVE TISSUE GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00219">
        <property type="entry name" value="IGFBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00121">
        <property type="entry name" value="IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00222">
        <property type="entry name" value="IGFBP_N_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51323">
        <property type="entry name" value="IGFBP_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="IGFBP N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="5">
        <location>
            <begin position="170"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR30487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="272" mass="31023" checksum="2AE0E78BF8A9B4F9" modified="2025-10-08" version="1">MSYPLSRYSLLVCRYPCTCPVRELTCVDGVSIVKDGCGCCYMCAHQQGDSCSVKDVCDVKHDLICDMSVGDVPGTGVCKSNTSKPCWVEGVRYSDGKQFKPECSRQCTCQNGNYGCVHLRPRLMEVAGQCCRQWTCEGQERRTASSGSDANEHKATSIQSSEPSCTKKGCTPTERLGRQHIRYADCISVKDWNLKFCTTCKKRRCCYPRKERTRRLEFQCGSSRRETFDFMWIKSCRCDKQCYEHAPVTGGKAKRGKRRRRFRQGYSNYYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9Y6</accession>
    <name>A0ABY7G9Y6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CSMD3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_003606</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050350">
        <property type="entry name" value="Compl-Cell_Adhes-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325">
        <property type="entry name" value="COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325:SF575">
        <property type="entry name" value="LOCOMOTION-RELATED PROTEIN HIKARU GENKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="35"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR30038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="95" mass="10318" checksum="6DBC0A3D3AB3E005" modified="2025-10-08" version="1" fragment="single">MFTCDFGYNLKGPSSKTCDEFGIWQPRESVDCIVVECPSPDNLANGLIYTTNGNRFGSVITYTCNRGFAAVPFSSQTCTGNGFWKPIGVASCRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAV7</accession>
    <name>A0ABY7GAV7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_014050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="81" mass="9347" checksum="A36EFA37E4D5C57C" modified="2025-10-08" version="1">MDRRQSEGKEYKRREDSRSHGRSGESSWLRKSERGIAESFSCRAHYDVPRTPCDSAEGVPPRGSPPIDELPSPNLRRKRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D8Q5</accession>
    <name>A0ABY7D8Q5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ACHA3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_006518</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Bcl-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06845">
        <property type="entry name" value="Bcl-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Bcl-2 Bcl-2 homology region 1-3" evidence="9">
        <location>
            <begin position="470"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAQ94047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="619" mass="71139" checksum="B4D119186EE153DF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBZ8</accession>
    <name>A0ABY7DBZ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YMD3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ93904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="191" mass="21991" checksum="0DC0EAD15357F2E1" modified="2025-10-08" version="1">MCSLFTIKCVYSNTNTSLHALSGKEFKAKLVQNLTPKLDVHYFPTQNKTKASTSERAILTIKQKLYRYITHKDNYSNLPSDSYNNNYGRTIAMRPANAKGNKQEEVRLATYFAQNPKGKQSSPKLNPFTFKIGNYVRISYLKGAFTRAYDESYSGEIIRVHTRYHKGTLSIYRIRDLQEEDIKGTFYESGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCW3</accession>
    <name>A0ABY7DCW3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_028202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ95512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="355" mass="43357" checksum="874D38D49FE1A926" modified="2025-10-08" version="1">MKLQANTRDYMGYNVITFNRDYINYVITLNGDYINYVITLNGDYINYVITLNGDYINYVITLYGDYINCVITLNGDYINYVITLNGDYINYVITLNGDYINYVITLNGDYINYVITLNGDYINYVITLNGDYINYVITLNGDYINYVITFNGDYINYVITLNGDYINCVITFNRDYMSYVMTRNRDYMHYVITFNNDYMNYVITFNRNYMSYVITFNRDYMSYVITFNRDFMNYVITFNRDYMNYVITFNRDFMNYVINCNRDYMNYVITFNRDYMSFVIYCNRDFMNYVRTRNRDYMSCHNFQQRLCELFHYFQQRLHELDCMNYKITFNRDCMNYVITRNRDYMSYVITFNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDN4</accession>
    <name>A0ABY7DDN4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="97" mass="10852" checksum="DE9B6B16FAD22626" modified="2025-10-08" version="1">MAHKRRAGGMTGITVTFDEDMPVTIRKISSSETKQTTKPVGRFMSKVMLISSHSSYQWSLQPQQTLCSLVMIQICSYFSSTIPISIHINSSPNLSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFD8</accession>
    <name>A0ABY7DFD8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S23A2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_006211</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11119">
        <property type="entry name" value="XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ93740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="494" mass="53815" checksum="F2528C46AD3F4823" modified="2025-10-08" version="1">MSTENGTIGSQGEVNGDVMLTHFRKKDDDDANGEVETEETQVYIENYKDKLLIYGINDSPPIHVTIICALQVAVCASKNDAFKARLLSSTLFMSGITTFCMNIFGISLVLAGFVHALLGFTGLIGVMLRFVGPLTIVPTLTLIFIFIVGPVIKFVENNCSSRDPVSVPCQIQHARSRLDAFLGFPDNSILISIVLNWLLCGVLTYAGLLTDDKKNIGYNARTDARIQIVRDNPWLTFPYPATLISVLDSIGDYYACARVCRVPAPPKHAVNRGIMIEGLCSMLSGAVGCGHATSTYGGNIGAIGVTKVASRHVFIATGVIYILFGIFGKFSALFISIPYPVLGGAIVVMFGIFFGVTNMSSPRNIAIFGLSIFIGLAVPTWAKKHKSPVQTGHAMFDKIMSMLVGNPNLVGTIIACFLDNTVPGTAEERGIAAWQVSEEDERADVDRTEFNEGYEVYDPLIPRSIMYSKLMKYIPFLPYKRGNVEKELGNVKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DH29</accession>
    <name>A0ABY7DH29_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NHL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_006781</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14954">
        <property type="entry name" value="NHL_TRIM71_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16524">
        <property type="entry name" value="RING-HC_NHL-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="687"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="732"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="779"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="826"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="873"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="923"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="455"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="557"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ94310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="960" mass="106800" checksum="9BE4D55AE6C05B70" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHM7</accession>
    <name>A0ABY7DHM7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ORCT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_029874</name>
        <name evidence="8" type="ORF">MAR_029954</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="63"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ97184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ97264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="499" mass="55455" checksum="069726FA77ED68D2" modified="2025-10-08" version="1">MINEHSSEVNAQVLDDNVNQAKHVDAANELSGNRKDTKSDVVETPEQIVEVLGGCGRFQIRVSVLVHLIKTFMCFSQISMILISSTPPWACADSQTDAPSNATSCSDDEERNSTYCPSRNCLTYNGTRCNQFYFEGRSRTLVTEVFGTLIANPIAGQISDIVGRKPPFFLSIVICIFGNLLGFFSTRWIMFAAARFLIGVGCGFFFSTQFCLLCEFSLAEWRAWIIGFPSWPVQASLFALVAWLIQDWRYIQLFTCLFGLPFLLTFFFIPESFRWYLSHDKTEKAAHVISKIAKQNKKEVPKLDHLSKDTEADRKYTVLDLFKSYELTKRTLLLSTNWCANGLAYYGISFGIQSLSGNIYLNMFLFNIVGVPAKTASMVMTNYFGRRSTSAICYTIVLAGCLVVGVVQLTVAKHWLEIPNSATVVNTAAIISSMAIVTAYGPVQTHTIELFPTVIRNTAFGCLSVVLRVGAMLGPQFVYLTKGGALTDKMGAKQSRANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DI39</accession>
    <name>A0ABY7DI39_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="305" mass="33790" checksum="729DCD37E9BE0A35" modified="2025-10-08" version="1">MTWCGLQFRSVYGSCWPLSFQNCRTTGLRSVCRPEASTSGRAGAQCHGSVTVTDGLAVCIGSKVSKPWFTVSFLTNLPAEISTTHLTKTLSEGQKSSEVSAIPFVQKSSASACYGSQAQDLGHPDFQSEYCSSSTWFIPPTDFQSKEASTKNNCTTATCPSDYSGPVSWHTTHSAMERIHWRVEPNPHCNPPGENMDITKVVLEKMKTYGVLETAKYLNERNSMKSIKEGENFERFMNKPYELPTPMESTVTTDQGETKHTTNRSSELVIEEKDTINDSLEEKEKSLDYHKKQLKGQPIGKLTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIX1</accession>
    <name>A0ABY7DIX1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_028718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ96028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="59" mass="6597" checksum="DB96D10626C0B696" modified="2025-10-08" version="1">MNSVSDNANSRKCLFQARWLWNQWQRANAANADALINRARRDAGEVSYTKGDAVGEALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJC2</accession>
    <name>A0ABY7DJC2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MAR_030124</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="7"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="111"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="209"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAQ97434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="306" mass="33365" checksum="A2317A2E84BCB8B8" modified="2025-10-08" version="1">MSKGSDVSFLENFALSGAAAIISKTAAAPIERIKLLVQNQDEMLKTGRLDKPYKGVIDCTMRTFHNEGVLPFWRGNLANCIRYFPTQALNFAFKDQIKALFKSSKNEGYALKFGKNVMSGGVAGAMSLCFVYSLDYCRTRLANDAKAGKKGGERQFNGMADVYKKTIASDGIQGLYRGFVISCVGIVVYRGCYFGFYDTLKPIIIGEGGSFLASFALGYIVTISAGLVSYPIDTIRRRMMMTSGEAVKYKGSIDCTMTIIKNEGFMSLMKGAGANILRGVAGAGVLSGFDKFKEVYVGWRLGQQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DK84</accession>
    <name>A0ABY7DK84_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_029594</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046292423" evidence="3">
        <location>
            <begin position="16"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ96904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="321" mass="36208" checksum="9AAFA7B4D83D5B0D" modified="2025-10-08" version="1">MTSLFASVTFTAVLAALSVICQTTGLIFPGWLTVESKQFSLNMALWFVVFCQHRVVVNSTNTTTTCEKFSYGRFFAEMKPSTAANLMVGYESQVGTQIQVTSCWLLALLALLLLMLQWRTLRHRSRRGFTIYEDEPRGTCNSRAKFQYSGGFAAIFQMFSGVLLSLVIVDFSKKYHSIKEPRPSIPYTLLISGAAVVCSALCSVIQMYIVFHVRENPPRQRQDSREETVDAQQKIPMSDIMQGAGHASDPEARHSSMDNGEYMFGLEYSNEGPPLMYRTQGTRKPDKPAHPFPGYKLAKQNMKGHDKKWWSKVTFASVPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DL40</accession>
    <name>A0ABY7DL40_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TMF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_030288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022092">
        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="6">
        <location>
            <begin position="1258"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="571"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="721"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="752"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1045"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1264"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ97598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1369" mass="153147" checksum="231A019F6F34CAA1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLK7</accession>
    <name>A0ABY7DLK7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_030297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ97607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="518" mass="56734" checksum="08768E5CE1B9EEEC" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMK2</accession>
    <name>A0ABY7DMK2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_022132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ97759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="88" mass="9846" checksum="21AF12602BFBDA40" modified="2025-10-08" version="1" fragment="single">MDQTKGVMFSRLCEISSFCTALCWRTTYDAHVSPVPCICTPTDQTKGVMFSRLALWITDQGRQACPMDHGRQACPIVHGRQANIIVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DN91</accession>
    <name>A0ABY7DN91_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="18">ACH2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MAR_022721</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">MELC-2E11</strain>
            <tissue evidence="18">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Synaptic cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19031">
        <property type="entry name" value="LGIC_ECD_nAChR_proto_alpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 14" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044953168" evidence="14">
        <location>
            <begin position="24"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="16">
        <location>
            <begin position="31"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="17">
        <location>
            <begin position="264"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WAQ98348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="514" mass="59039" checksum="2C21A2FB343B1229" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRA0</accession>
    <name>A0ABY7DRA0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4537 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_024312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd04508">
        <property type="entry name" value="Tudor_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032770">
        <property type="entry name" value="DUF4537"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15057">
        <property type="entry name" value="DUF4537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4537" evidence="2">
        <location>
            <begin position="196"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ99939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="449" mass="51300" checksum="16717D3D286BA54B" modified="2025-10-08" version="1">MAKQRSGFPALVRVFNKEEKVFYEGKVEGPLQNGGNRRYFYNVRFNGNDEVDPVDRDDVEFRGGAMPWRKLKPGDRVLAPISRPCRTHSLPNHFQNTSWSNNMIGEQRSAFVEGVVDRLPIPADGIRRYKVVVGSGEEIKTLHLSRKQIKPLGGNKDAEKTDNRPAPIPSDIQPVKIPTKDKNSQAPESEPVSGVVLARWREDGWFYFGKVVSNKNDEYFIKDGLGFNEMIHKSDVLTETSQKFQVVQPDDKVIALHPNYIFSYAPASVKRVYRFKGADLKFYDNTVGTLPWSKIYKISDQKYADCVHHIKQKEKEMLQANVIVFDEKCGHFENGTVSDHIDNQMYTVNLTARNKAGHLEQQANHMFLKRTILSTDVDLKPKYVIGRVNDVFLSGEICKSTDTNGKKMPNETITVLFCNLEKTTVHLNDVYPINKNYFDFAVDIWKSCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRC8</accession>
    <name>A0ABY7DRC8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_024342</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ99969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="215" mass="24093" checksum="B8C660D04C37E0F1" modified="2025-10-08" version="1">MGKARSKWEETHLFTRLSVGLLLIITLLQVIGFSAPYWREDDPVVSDGPGVRVHQGLWLYCVCEDSCSCENIAGMPDGNVNASWLRWSQGLEAVSLVLMLLCCLLAPLSVLCTDSRDVRLALVAMEPFAGFLNLMAVTIFAINVPRSSQQWCFYMCAAVGALAFVFHFLYAFGTRNRLHGAVSEVRPTIHAQMVKVPMDEHMFRKLMKREGMFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSB2</accession>
    <name>A0ABY7DSB2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18576" checksum="258693605F38453A" modified="2025-10-08" version="1">MSDRASTETKFNELLQEMNNFFCGLHTLVQMADTAQKTVYQTEKLNARYLTLLKYLEDITLNLDNFISGDMLLYNDIPVKTDIVHDFLIEKADGIDCHVIVILHVVLPAFAILIQRQYGDHLPGGKHEELNEIETASVNKHNKFPERVFSYVDHILSSKPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DT19</accession>
    <name>A0ABY7DT19_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenomatous polyposis coli N-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_025234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032038">
        <property type="entry name" value="APC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036149">
        <property type="entry name" value="APC_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16689">
        <property type="entry name" value="APC_N_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58050">
        <property type="entry name" value="N-terminal coiled coil domain from apc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenomatous polyposis coli N-terminal dimerisation" evidence="2">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR00862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="181" mass="19858" checksum="BAA57605330C1B3C" modified="2025-10-08" version="1">MSSHEELRKQVESLRQVNTSLQQEILHNSAHLSRLHENTTQLARLTSGSTSQSSSQSNSNTSSPRVSRHQAASHHTGRGQSGSSDSSPRINRQPHPAHTSTPRCLDSTRNHIGHSQPSPALQQRLFQQNSVFASWQNQESAISHLSKLQDVPDNHQPRQAHVTSSSTQGDLSISADLSQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTI1</accession>
    <name>A0ABY7DTI1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_024365</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable methyltransferase required to silence rDNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAQ99992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="171" mass="19117" checksum="24CA342DCEF50FD4" modified="2025-10-08" version="1" fragment="single">MEASSDEKQKDATKGQGAQSSSNKSENIEGKFSKNISHNESDKRITEANMKESKSGEKTLLEKSRDRLSAARFRYLNEQLYTSTGKEALDLFKKDRDAFSVYHEGFQGQVEKWPTNPVDIIIKQIKSKPKKLVIADFGCGDAKIAQSVANKVHSFDLVALNDHVTVCDMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DV41</accession>
    <name>A0ABY7DV41_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CADN2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_007878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="4">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR01320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="466" mass="50478" checksum="2067838A408E2542" modified="2025-10-08" version="1">MLTGGHLQLVYNMGDGEVALILSEIRVDNGQYHLVTLERHGSTFILKLDGGEWRYYTETSGRDSGLRDFSIRQDRIVAGASVSYASGSPVYYGDDLSNTCIKDVRIDNSWFPLTFEEAILSPAAVLVFSANVQEQCSRDDCPPGQCTPPKYVCLSGKTSHARDVLAMVNGMEIFVNAIHTLTSRTVQRVEHRLQQGQVERTRCPFCVGRGVTNGPGCTSGVGTIVCKQDASLQLLFYTYAGEIETADIGTVVGAVIGSIVCIFASIAMVIFVYIRYRPSGMAVLLQLLRPGTGNPKSSTNENETPYDTIDENVESLVLSPVQTGNTNAESVDTAVEETVVTSTQSGNTHEESVDTGLAETDDASQPSSSVLSESAYTTIDGTDDGTVQSGAQEHYTSLNDRNGPDRTYSTLPHTGAQEHYTSLNNRNGPDRTYSTLPHTENGTENPISTMNSANYTDLELEANSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWB4</accession>
    <name>A0ABY7DWB4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IML1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_008298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="2">
        <location>
            <begin position="754"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR01740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1051" mass="122361" checksum="517D9E42061098A8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWF7</accession>
    <name>A0ABY7DWF7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SC5AB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_008616</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819:SF196">
        <property type="entry name" value="SODIUM_GLUCOSE COTRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR02058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="490" mass="54583" checksum="C9C5EAE7C9625DE3" modified="2025-10-08" version="1">MQSKRISHWGDILVLAAYFCAVLLVGVWSLCRKHRGTVRSYFLAGRSMSWIPVGASLFSSNIGSEHFIGLAGTGAASGLAIVMYEWLVSIFAGALFIQLSMGWNMYLSIAVLLVVTGLFTILASLRNANNTCGMPRDDAFHVLRDAVTSDTPWLGTIPHILFGCMWYFCFQRSLAARSLPHAKAGSLVSGYLKILPMFIMIMPGMISRILYPDEIGCVLPEECERHCGNPVGCSNIAYPKLVLELLPAGLRGLLVAVMLSAIMSSMTSIFNSASTLFAMDLWPRIRHGASQRELLIVGSGQLFMYIQAVQGYLGTPLGPIFIFAIFWHKMSEKVGFKYIFIGTFDLTQSFITQAAFWSLVIGHVCGVTRMVMDFSMEAPGCGEPETRPAILYKVHFTYFGVISFTITSICIVVISFFTEPSDKINIHCIVCNSFFTDKISGLTWWTRNYIQHEEEHKPSLSKEIYQIKGMFGHKKVLLPRILSSFKSMTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E050</accession>
    <name>A0ABY7E050_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reelin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_008786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045071959" description="Reelin domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="2">
        <location>
            <begin position="36"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR02228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="12207" checksum="577CD7CEBFC1BE21" modified="2025-10-08" version="1">MHTAAALAASMLILSCLNMGFSYPNGAPPSSCSSMKPGHVTLAALKGFNFTGFLCQARPDQADNATTGTLYGEYSKTTNNCDGKGSVTHSTRDLKESMVLKWKANSNYTSVTFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2K5</accession>
    <name>A0ABY7E2K5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RFESD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_009596</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054716">
        <property type="entry name" value="Sol_Rieske_ferrdox_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF25">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22543">
        <property type="entry name" value="Rieske_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="45"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR03038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="167" mass="18625" checksum="C9223DE6E35A64B3" modified="2025-10-08" version="1">MENLVYLPVEKIHLNDLYDWSIPVQRCKSTKVALSPVGSPASSPRKSGVKVDLENGKGTGSLVKTNEHDIALFRYKTTVFAVKEECPHAGGPLHLGEIEDLGDELLCVRCPWHGWRISLHDGHVTLPKGHNFQSTVVYPVKITQEGQISIGFRGLDSKYFKVDEVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2U2</accession>
    <name>A0ABY7E2U2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_010092</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046526356" evidence="6">
        <location>
            <begin position="23"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="7">
        <location>
            <begin position="32"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="238"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="297"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR03534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="356" mass="39702" checksum="A47F1D680B53FA64" modified="2025-10-08" version="1">MGSIFVWTIALLFVVWAPMTKGQCRANTGPVDLVIAVPGSNHVIPENEFSAFEKNLINLLMHFAIQPDEFNIGLILYGKTAIPIATPQPFKTRTQINTRVTLLTERMQYQHELGTKHDVAAALNLMINMFKVPPPGYTGNILRERARRIGIIFTFAAATRAKSDGILLYALGSNGTSRDFIELGTDYCRLFSMGEFSDGLPFAMPDLASGICSEVDPTVNITEKNCFPRRYPKAHGIGVSCQVEGNMMQADPNNCAYYYQCEYFDKNPRRMQCSASTLYDPLTKICNALSSVACYNDITCPDDKPALHAHPMDCNKFINCYNDRIPHVQSCPDDQVFDPQTQTCNKTSTACMHQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E329</accession>
    <name>A0ABY7E329_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_009765</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF216">
        <property type="entry name" value="PROCOLLAGEN-PROLINE 4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0847">Vitamin C</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045779700" description="procollagen-proline 4-dioxygenase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="12">
        <location>
            <begin position="407"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR03207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="529" mass="60984" checksum="01EEE92FAD1CFF21" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E461</accession>
    <name>A0ABY7E461_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TM245-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_020176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="563"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="628"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="653"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="695"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR04807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="780" mass="86720" checksum="236F801B486E14E2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4B9</accession>
    <name>A0ABY7E4B9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR04049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="11198" checksum="DCAE1A54B9D5E5DF" modified="2025-10-08" version="1">MHKVLQFDARAWFKEYIDFNTQKRTYAKNAFEKDFLKLTNNSVFGKTIENLRKRDSHADKHLFDNSDYPSDDKFHNKKVIGKVKDEATSFCNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4Q3</accession>
    <name>A0ABY7E4Q3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IF2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="577" mass="69225" checksum="B53887504DE6CC98" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E582</accession>
    <name>A0ABY7E582_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NP1L4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_008864</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR02306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="346" mass="39300" checksum="E761088D37A24448" modified="2025-10-08" version="1">MADPEGKPEELVGEPTSEENPTSEEPSSQGDDSAQPAILASQLMRDPQMLAALQDKLGSMFEATTIEAEFYREVHRLECEYATKYAPLFEKRSLVVTGTHEPNDEEADWPSDDEKDEDLAKDKKELASGDNKNTKGIPGFWLTIFKNVDMLSEMIQPNDEAILNHLQDIKVEFTEKEPMGFTLQFLFEPNEYFENKKLTKEYVMRSEPEEGDPFSFEGPEIIKCVGCKIDWKKGKNVTVKTVKKKQKHKASGTTRTIQKTVQSDSFFNFFNPPTEALLAADFEIGHFIRERIVPRAVLYFTGEAMENEDDYEDGEEEEGGEEGEYDEDADPDFSPGKEKPAECKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E641</accession>
    <name>A0ABY7E641_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 231</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19319" checksum="1C2AF13E8CBEBD96" modified="2025-10-08" version="1">MSGSPCLVHNTTDPGEVFYDTAQFAISDTVKLINDVLYFVVILMKQIKAENARQAYSIDCYKDIYSHVSSNESAIHLHTFPGKEYKHFIFTRPLCAYVPFHRNRRHSIKTTCFIAEPTDLGNNLSFMKTYTWIQNLFRYIIPLVVLTFLNPKIIHKLKREGIKGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7J8</accession>
    <name>A0ABY7E7J8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_020136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR04767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="179" mass="18939" checksum="9753810482859D0A" modified="2025-10-08" version="1">MLYVSKPDDGRAAALLRYKILAGLMGFLSVGLLSIGIIAVITGQYILSMFLFMGCFIGTILAGIGGMNTDTYGFDDEGTGYEDKVKLLAGTVSTTNTAYGGSGMGGMGTNANTQNLQEQNRLLQEQLRLQQELINTQQRAQGPQFGVYPPPPANYPSGGTYPASDPAYPPGPPPSYGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAX4</accession>
    <name>A0ABY7EAX4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_020938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284:SF12">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046840876" evidence="6">
        <location>
            <begin position="24"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR05569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="195" mass="21321" checksum="1CC1BB4041B3FDE5" modified="2025-10-08" version="1">MASFLAISAIICVLIATVATIVAFSTPNWIEFEGNGDMLCNCHHCDCGLWLHCTGGSLTDTGNLDNCKWFFGDEFFIERSLPDWFKAVQGLMSCALASTMLALMIGLFSLCCSCRSCNPNMAAGAFANLTFLLLAISVILFGVQAHRIHFAEVLLEQGSNAPVYGWSFWVATGACLMSLLSSLLYFCVGRKEDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBR6</accession>
    <name>A0ABY7EBR6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="74" mass="9359" checksum="868F28901E392303" modified="2025-10-08" version="1" fragment="single">MRSLPRRMRRLPKRMRSLPRRMRRLPRRMRRLPRRMRSWPRVKELMMQTFPISVPTMSLAPHQKLRHLQTKLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECG5</accession>
    <name>A0ABY7ECG5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_017518</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR07560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="256" mass="29161" checksum="AE494366553CEE4D" modified="2025-10-08" version="1">MKSDEQLHILKKMLEKVHFEQYFLIFWKVFIEDPLKPSQRFLTLAPLETTYHADKASGRGMLLAVNTCVCTPGDCSLSVVKKPSEKSLARYSNTAEVPQIRTTKYGLNSFRSTATKLWNSLPQHFRDETNLSQFRSPKTIFFWAPTMKWCLVIAGIGDIARPAEKLSQFQSSALAATGLIWSRYSLVITPKNYNLFAVNVFVGATGLYQLYRIYKFVMEEICWPTISEAKGPMKRLYLLIASCISAGWMACDIEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EE71</accession>
    <name>A0ABY7EE71_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NIDO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_016667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF52">
        <property type="entry name" value="MUCIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIDO" evidence="2">
        <location>
            <begin position="3"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR06709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="176" mass="20110" checksum="E860B5379A4B54D5" modified="2025-10-08" version="1" fragment="single">PSLNGFLALNYPPLYESYGAENSTLWKKYVENHVVIAPLWTNLDSRNITGAGVWVHVFSNNTGNRSDILKIQEHVQKYSNNSEFNASVAFAVTWKHVTIHSPYMPGYRLYKHQAIMATDGLYTYMMFIYDQEQFSIKPLSYTPVAAGYTFPGNFTGKILADRHNFTNLKNESNINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEE3</accession>
    <name>A0ABY7EEE3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRE4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_017125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR07167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="103" mass="12009" checksum="AFDC0BF5D0AA2BCF" modified="2025-10-08" version="1">MILIGFFQVIRMLYKSLVGGVLSFRDKHFTKVNGYSNLYWGWGAEDDDMHKRLSLLKTSTTRYLKDGLNTLEYKLVETRLEKLWTRIIANVGDPPKNQTENPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFW0</accession>
    <name>A0ABY7EFW0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="422" mass="48465" checksum="0BBAB705FCCB4EB8" modified="2025-10-08" version="1">MTGENRDSDYSERLVDFQIISRGKTSMAAKRKRENDSATDTDLPDFGIADTAIDIAEQADLLQSIPDFFEDTNKMELVKHPNWTHSWEPIVLKPFQYVSPHLRPSITSRDGTQREDIGWDVVEGTDEDGELSRLDTRIKDFLSGSMCDDNDESMQAPDEYMNTDDCRCKTTYMSLFDLDRIQEHILSVREMEKSEKDLYVMGSLQKFAHENTKGGKRKRIRYRYVYDLRNEEADKAGIRISGPRDDVCQTCELLRKKIVDAVLEQDKLDASSAFLEHVEVAQPVRTGIPELEDSNGAAEEILLLMCLVDSGFANIKKLFRRCDVDSLAQLAEKQTNCRLDWKSYLQLDFLPVRGIQKYHSFRFCKADSSAVYIKWKSGEPEGRVQLMKRAAVLPQGMPNTVTPAGLTAERRRYLRMHVRQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHP6</accession>
    <name>A0ABY7EHP6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="217" mass="23980" checksum="E7E9B8C12373E30F" modified="2025-10-08" version="1">MAEHACTKLKAQEVLLINGGKSTPCVIVTTNGCCNQPILDTNQEEADTVMILHAKYEADRGSTCIAIHSPDTDVLVLLLHHYRYIGAAHLCMSTGRVTLHTDVHQLIDKLTKDQLNILLSVYCITGCDTTSGYFGKGKRRVFKLLTESASNYQPLFNLGEELLLSDLQRTACTRFVISLYGGNDVQTLQQLRCIKAKSSVHPRNIPPTADSLNLHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHT6</accession>
    <name>A0ABY7EHT6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="111" mass="13046" checksum="78E088A742A31E75" modified="2025-10-08" version="1">MTKMTVRSMDEFGRSLTKGGLRLSSDMYPRKREDTLTVEGKEHKIITDSRGNEVYMYQPNPEDIRRQPSSRVSSSERDFSRPRTVSVYDYIDTESRCEIQRPILRPNVNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EI88</accession>
    <name>A0ABY7EI88_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="72555" checksum="2F5204F20AE78E02" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKE4</accession>
    <name>A0ABY7EKE4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_017604</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045426248" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="253"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR07646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="333" mass="36949" checksum="F0AB64A5531BF6CA" modified="2025-10-08" version="1">MRHSFIVFQLLCGFYRPVFMTVVEHVFERKPSFDGFLCSQSSNNCVNKRNMQSCARECGRSEMCKSFFYDFDSRDCFIFETIFSDTNGCLNRNGHYYQLKGLTTASSMTTTTSTTRTIPITTPSTTTTPNTTTRTSITASTTTTHTSTTTSTPTSRSSTTPTTIMTSPNTTTTTTTSTTYSPTTSTTSTALITTIPSASTSTALVTTTTSIVTPCEITANCQANANLACIDDTCQCTDWLRYDPSSDMCLTDCPSAYGNTYTRRADKIMWTNVIILDILPTTLENCFDQCSSDLTCMGVNWKASGQWCALKQEISNSYFIDSTDWDWYTRNCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EL48</accession>
    <name>A0ABY7EL48_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TULP4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_019429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TUB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF2">
        <property type="entry name" value="TUBBY-RELATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubby C-terminal" evidence="3">
        <location>
            <begin position="503"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR09471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="606" mass="67951" checksum="C31B0DD3AC144D0B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENN3</accession>
    <name>A0ABY7ENN3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="225" mass="25613" checksum="28200B0BB1714BD1" modified="2025-10-08" version="1">MEREINERVSKIKKCSDSEWRYCLNNLVRDQDLFDRLSYLPEPIPDDSREHFFPLSDEPKAAGTISFDEFVEGRSEYEMSDSDDFDDDSDDADPCSVSLNYPVKPCSVSLTYPVKPCSISLTFPVKPFSVSLTYPVKPCSVSLTYPFKPCSVSPTYPTKQCSGHTWNFRERHQVDHLSSIGGSSVKAMPKRVMKAVMKNSAVKRNFPSSDNSVTEYFLNDWLRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENX1</accession>
    <name>A0ABY7ENX1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_025870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR11690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="401" mass="46524" checksum="6E0794D4D1C8049C" modified="2025-10-08" version="1">MTDDINRSHRAKLKNLSEIYVNNFRKSTETPRIATNLVFDSDNVTSTCARVITCPIQSASSGTWIEVGSDNNMFIFSAFYVEKDKHVIIVGAKERGITRATYASYLFKCSPPGGKMPRFVSVVKSNCTVPPKILLVKPTRPAGSYGRQFTVCLMPLNLNYSRAYELVEWIELNRLLGADKFMIYNESSAPNVNKVLNYYAKRDIVDVIQWPIPLDNREIHYFGQVAMLQDCLYRNKEESEFIVNEDLDEFIIPRPLLLKTWHDFVKNKSEDIAGYIFRCTFFRKEWVDTEIDFSEKRIAEKYKLITLLRFGHETKLWNYKARSKYFARTSTVESLMIHEVPSVKTENVHQSIAMIHHYRNWSNFKPQEKVHDDIVLQKYGKQLLKNVAATWDNLPGVALDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPI2</accession>
    <name>A0ABY7EPI2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SACS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_036231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052972">
        <property type="entry name" value="Sacsin_chaperone_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15600">
        <property type="entry name" value="SACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15600:SF42">
        <property type="entry name" value="SACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="2">
        <location>
            <begin position="46"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR11155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="109" mass="12452" checksum="9391760DCC7A014D" modified="2025-10-08" version="1">MECLKTIRASTSDGRRKGKRKSTSQDMDKDVVKKKKPVYSGFKQPTLIEQLKYILAEYPDGGQILKELIQNAEDAGARTMGILLDERRLNRTDETSPAQYKKFFQIILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ER19</accession>
    <name>A0ABY7ER19_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="85" mass="9503" checksum="C30E5B5F4DCFEB07" modified="2025-10-08" version="1" fragment="single">MNEASDKSCDLCDIGIAYDAHYVDIEIGSFIGITRAHATDADSFAKALVYKQFQVDIYACEWKFDFELRETDIAIQSSIQSGVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERL2</accession>
    <name>A0ABY7ERL2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ARMC4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_025626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46241">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 4 ARMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46241:SF1">
        <property type="entry name" value="OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="494"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="711"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="836"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="918"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR11446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="999" mass="111278" checksum="8710FF89D3774D5D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESD5</accession>
    <name>A0ABY7ESD5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_025811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="6">
        <location>
            <begin position="89"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR11631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="253" mass="29281" checksum="185E2463C28F3462" modified="2025-10-08" version="1">MASRFGRFLRPLAVNLAKTKVLPQTRVVSHAFRLQSTSTGAAEEKSPTVRYADPVKTKALTDFGQYVADILPKYVQKVEVCHGDELDILIHPDGIIPTILFLRDHHHAQFLNISDITAIDVPSRTYRFETYTDELTPMDSITPVLPAANWYEREIWDMYGVYFSNHPDLRRLLTDYGFEGHPMRRDFPLTGYMELRYDDELGRCVMEPLELAQEMRKFEYSSPWEQFPKYRLADPSKEEADPEQVTGGTEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETM6</accession>
    <name>A0ABY7ETM6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RIT2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_026083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF6">
        <property type="entry name" value="RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR11903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="405" mass="46050" checksum="3EF956F33A3D4AB6" modified="2025-10-08" version="1">MNSDKVKQKFSVPKICHEVSYDVKTDHEEPTVVDRNHLFQQKMELRESENVAQNHSNLNPTTHHGRSSSFRNRPRPKLLNVDVDRPRRSSLPSIARNFLSVSFDDIHKEEEPSDQRRVRSFKTTSKGGIVNRGDSFKRSSNSIHSTGSAMHSEHGGTRSHNNSTHTINSKQSRYIGTLDSMGSSMETVIHKVAMVGDKGVGKRSLTNQFMTSEFIAFDAENDDEETDSLVTVLLNSEESTLEIDDRPFDLQEMSSRSVDAFAVVYSVTDRSSYQAAVDIMYHVRHQLLIKDKPAILIANKIDLVRKRKVTREEGRSVAKQYNSKYWETSAALNHHVDELLVGILSQIRLYKTPGLPIDPPNFDVKPCQNKHAKCFIPVPKRLLNFIFCKNPMPTARHECEDLFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETV6</accession>
    <name>A0ABY7ETV6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF13">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="151" mass="17877" checksum="9BEEA2873E720A17" modified="2025-10-08" version="1">MEYGVIECVRFYFTQILQHELDTVRQEWNDHPIRRQNGDEINGRPEILYQHPDLYGAIDANSSSSLPYIECVRFCFTQILQHELDTVRQEWNDHPIRRQNGDEINGRPEILYQHPDLYGTRDYEFPVEMADVVTFRSFCKTLAVKSPCKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUG9</accession>
    <name>A0ABY7EUG9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027116</name>
        <name evidence="2" type="ORF">MAR_027120</name>
        <name evidence="3" type="ORF">MAR_027131</name>
        <name evidence="4" type="ORF">MAR_027136</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR12951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR12956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="34" mass="3841" checksum="B04B9BD7C2271C13" modified="2025-10-08" version="1">MTAVTTTVHVRTDRRASTGVEIGVPRIIWRRAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EV00</accession>
    <name>A0ABY7EV00_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CP17A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_027300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF20">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR13120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="442" mass="49978" checksum="03176FAFA2EA191E" modified="2025-10-08" version="1">MSVEAYLPSSPITTGLVALVAGLFSFWLLRRMRYNYPPRPGIALPLLGHAYSPMKTVVVNKIDEALEVLVKKSTDFANRLIVPSVEMFTDGGRDIVFSNYSPTWKLHRKLSSKALRYYMQGPALEHRVHAALETALAEMDGHADSPFDPVEHINFIVGNILTGLCFGGSHVYKSPGFRKMEKYYKEVIVDFIGKKYHDEKKTFKRDELRHLVDHLILARTEAEESEGDALVALTDTHIIQTIADIFSAGVDTSRMTLRFALLHMAAYPDIQAKAQEEIDRVVGRDRLPGLSDRPDLAYTEAVLHESMRIATVAPTGAWHETLCDTSIGSYKIPKGTPVIINHWALHHDPDAWDEVEKFKPERYLDEHGKLGPKPKSWLPFGAGKRVCLGEFVAKPELHLIFASLLQRYRWSAEPERVVDISPEKSPMSNTPKAQKLRMERRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EV91</accession>
    <name>A0ABY7EV91_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TCuncharacterized</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="197" mass="22369" checksum="AF7A6F2084FB58BE" modified="2025-10-08" version="1" fragment="single">MYHIYLDLTSRYMHHIYLHLTSRYMHHVSYHLTPRYIHYISYHLTTRYIHHISLHLTPRPDFSVHASYIFTSDFSIHSSYILSSDSSVHSLYILSSDSSVHSSHISTSDSSVHSSHINIFTSDSSVHSLYILSSDSSVHSSHIFTSDSSVHSSHILTSDSSVHSSHIFTSDSSVHSSHIFTSDSSVHSSHIFTSDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EV95</accession>
    <name>A0ABY7EV95_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">PIEZ2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MAR_027032</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIEZO (TC 1.A.75) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031334">
        <property type="entry name" value="Piezo_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056770">
        <property type="entry name" value="Piezo_THU9_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056769">
        <property type="entry name" value="Piezo_TM1-24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031805">
        <property type="entry name" value="Piezo_TM25-28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056768">
        <property type="entry name" value="THU_Piezo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049:SF2">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12166">
        <property type="entry name" value="Piezo_cap"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24874">
        <property type="entry name" value="Piezo_THU9_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24871">
        <property type="entry name" value="Piezo_TM1-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15917">
        <property type="entry name" value="Piezo_TM25-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23188">
        <property type="entry name" value="THU_Piezo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="696"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="733"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="782"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="883"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="925"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="955"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="988"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1025"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1048"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1094"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1212"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1312"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM1-24" evidence="15">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM25-28" evidence="13">
        <location>
            <begin position="390"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo transmembrane helical unit" evidence="14">
        <location>
            <begin position="690"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo THU9 and anchor" evidence="16">
        <location>
            <begin position="881"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo non-specific cation channel cap" evidence="12">
        <location>
            <begin position="1161"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo non-specific cation channel cap" evidence="12">
        <location>
            <begin position="1314"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="535"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="818"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF15917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAR12852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1396" mass="160440" checksum="DF22939FE0635034" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWA5</accession>
    <name>A0ABY7EWA5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="800" mass="92646" checksum="389A972BCFDEF362" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXP7</accession>
    <name>A0ABY7EXP7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRAM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053359">
        <property type="entry name" value="CRAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35577">
        <property type="entry name" value="CYSTEINE-RICH, ACIDIC INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35577:SF2">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="616" mass="64463" checksum="B9904A3A4A5FF4CE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZW1</accession>
    <name>A0ABY7EZW1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EST2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="29"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="171" mass="18528" checksum="B11B39002900DBBE" modified="2025-10-08" version="1">MIGVELISVEISQFVFTDAGYSAFEQSDLGGITGARMNVIANGTTKTVHVCLGVSYAKPRVCDLRFKNITETNSGVRVSIFSVVSIPVFTIESEDCLYLNIYKPKNRSGLAVMIHGGGLTSGSADKFNIKILASAFGNAVVVTFNYRVGIFGFLSNMDEHAMGNNGLWDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0K6</accession>
    <name>A0ABY7F0K6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="595" mass="67641" checksum="41CBC7D2425F9F72" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1T2</accession>
    <name>A0ABY7F1T2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1251"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1251" mass="142344" checksum="94118B8F161FBF39" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1W3</accession>
    <name>A0ABY7F1W3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_004946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR14841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="217" mass="23712" checksum="91F03D61823F9985" modified="2025-10-08" version="1">MSRPQSLKPKSAVAAIDFGTTNTGYGYYMRANKGPVSSRDIVMEQQLLTHDMKIVDASGKSMVAMTVFELSIKHVKKKVLERMELNMGDKIIESDVMWVLTVPAIWRDSAKQFMREAAVNAGISNAQLTLALEPESAAICCKEMALRKTEGIEGIMLKAFDPGQKYIVLDCGGGTVDTTGHEVQENGQLKELHAATGGPWGGKLVNDAFEEFISELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F383</accession>
    <name>A0ABY7F383_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FBX5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_031227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd20348">
        <property type="entry name" value="BRcat_RBR_EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22086">
        <property type="entry name" value="F-box_EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047147">
        <property type="entry name" value="FBX5_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044064">
        <property type="entry name" value="ZF_ZBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15493">
        <property type="entry name" value="F-BOX ONLY PROTEIN 5 AND 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15493:SF9">
        <property type="entry name" value="GH14043P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51872">
        <property type="entry name" value="ZF_ZBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="461"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="ZBR-type" evidence="7">
        <location>
            <begin position="528"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR16633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="598" mass="65664" checksum="CE53797953A01ED2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3F2</accession>
    <name>A0ABY7F3F2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="90" mass="10452" checksum="0A355BB2E943B2B7" modified="2025-10-08" version="1">MANLIDMTTLLGKLCCSMTDCHTKLIYSTGSQYGTDPLVEENQQLREENEKLRKELQMFEFGVNNSKDDDKDTIFYTGLPTFAFFMWYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F463</accession>
    <name>A0ABY7F463_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LAR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_031572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF534">
        <property type="entry name" value="LD27988P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="76"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR16978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="242" mass="27479" checksum="73EC1BDE41C12292" modified="2025-10-08" version="1">MKQMGDEDINGQFQEMQNVLGKTSDNEMHAVEEKRGIKGNIRPSPDIPETKCRIRSVTHFEFNAWDYTSDVPKSSKDYLDLIKSVDSTLRETSNRGPVLVHCLDGSGKSALFCVVSILLEKMDIYQEVSVVNTIRKVRSRRKSAIPSKEQFEFCHECVLSYVKSFEYSQYANFTTKSMVFLDKKWYSNVDVKPRFEMQVNGSVPAGNTGNEKQSTIVTKLYVHTSAESPGCIEAKLKNQCYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4Y2</accession>
    <name>A0ABY7F4Y2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="613" mass="68867" checksum="E700025D31FC2A68" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4Z7</accession>
    <name>A0ABY7F4Z7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="109" mass="12628" checksum="6FC61EBB9FF9C776" modified="2025-10-08" version="1">MNRDTGNRTTDICNNEQRYGKSMVLLNVYTCMDNNDNTLKSKKNFFYLTMILISKGIVISKFTRSHIDRAIMNTLDAVLLILFLYTQIVMIFPGRPTIIITITRTNEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5P6</accession>
    <name>A0ABY7F5P6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR17510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="33" mass="3897" checksum="0174CDB1A3CA594A" modified="2025-10-08" version="1">MHGTSRKRGGLRRMHRLFDLLGDLRAMYPDNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5V7</accession>
    <name>A0ABY7F5V7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IF2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053121">
        <property type="entry name" value="Spore_Coat_Assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35365:SF29">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35365">
        <property type="entry name" value="LP04239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="469" mass="53219" checksum="3F299196287F4963" modified="2025-10-08" version="1" fragment="single">VQGNITHTQRVQSNITHTQRVQSNITHSQRVQGNRTHSQRVQGSITHSQRVQGNITHSQRVQGNITHSQRVRGNITHSQKVQGSITHSQRVQGNITHSQRVQGNITHSQRVQGNITHSQRVQGNITHSQRGARKYNTQSKGARKYNTSLKGAGVRGNITHTQRVRGNIIHSQRVQGNITHSQKVWGNITHTQRVRGNITHQQRVQGNITHSQKVQGNITHTQRVRGNITHCQRVQGNITHSQKVQGNITHSQRVQGNITHSQRVQGNITHSQRVQGNITHSQRVRGNITHSQRVQGNITHSQRVRGNITHSQRVRGCKEIYIAHSQRVQGNITHSQRVRGNITHSQRMRGNLTQCQRVQGIITHRQRVRGNITHSQRVRDNIAHSQRVQGNITHSQRVQGNITHSQRVQGNITHSQRVQGNITHSQRVQGNITHRQRVRGNITHSLRVQGNITNNQRVRGNITQCQRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5W0</accession>
    <name>A0ABY7F5W0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">STAM2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd03568">
        <property type="entry name" value="VHS_STAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="2">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR17585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="363" mass="40754" checksum="496EB2E9112E8B53" modified="2025-10-08" version="1">MPLFTSSTPFDPDVEKATSEMNTVEDWGLIMDICDKVKNNNGSKDCLRSIVKRLNHRVPFVAMQALTMLHACVNNCGREFHLEICSRDFIAECRTLINQKAHPRVAQKLKFLIKTWAEMKEFKEDAALNLIPTFYDSLKKEKLDFADPDASPKTTVKLTIALSLQEEKTGHKTSSGLYPTTFGASGSSSSPRVREVRKVRALYDFEAVEDNELTFNEEVEVKTIEAPEQLDIDEEKIDDMLQQIQNADPTGETRPDAVEMLQKHADLCGINTKVLEALQMYHNLMKETPLPFQYKTMSGYSAGAMGMPPGQSSQFCNARTKPRIQPALFTTPADASPTKCSSFTTKYSYATEYECSSLTITII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7A2</accession>
    <name>A0ABY7F7A2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Leucine-rich repeat-containing protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_032667</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRAME family. LRRC14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR18073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050694">
        <property type="entry name" value="LRRC14/PRAME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14224:SF37">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14224">
        <property type="entry name" value="SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR18073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="618" mass="69037" checksum="41702977E0B193E1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9T3</accession>
    <name>A0ABY7F9T3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="148" mass="16707" checksum="30164A05759F0F81" modified="2025-10-08" version="1">MIETNKDDLITQFKNETSLRKKGTEVEQIFQAFQANRKYILAQSPMPNTVQDFLTLAYQENCSCIVSFEQSDGTKDMGEYNPADNQVLKKGQLSVACGRDKVANEYSIQKGLTIEFTGSTQAQFDFCHDCVLEFVRSFKTYSNIGGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9Y9</accession>
    <name>A0ABY7F9Y9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EHBP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_000733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022735">
        <property type="entry name" value="bMERB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF46">
        <property type="entry name" value="EPS15 HOMOLOGY DOMAIN CONTAINING PROTEIN-BINDING PROTEIN 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12130">
        <property type="entry name" value="bMERB_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01203">
        <property type="entry name" value="DUF3585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="488"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="605"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="880"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="673"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="725"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="778"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="897"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="957"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR18895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1126" mass="126359" checksum="5562C285B8A767F2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAK7</accession>
    <name>A0ABY7FAK7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BM1LA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_001045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR19207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="225" mass="26573" checksum="1E882AB4E10C4F72" modified="2025-10-08" version="1">MPTIENENMETEEDEMEQDSPDPDNSSDEESDGSASSDIVSSIFRLYKERLAQIDTKLEEMRAGRSQEYLDRLAQLQEQMQVRTQVAGILRELRMKACEIKHESEELAASQHMRSEKTLLFDSIRSELEEKIRRLEEDRHNIDISSDLWDESQTQKKNSRRKTMDPFNPDRRRKPVTVTGPYIVYMLKDGDIIDDWTAIKKALKQQQQQHLQKRRPEYKQTIQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FB58</accession>
    <name>A0ABY7FB58_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_001240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="342"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="574" mass="64829" checksum="3929849B5CA3D691" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBK4</accession>
    <name>A0ABY7FBK4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SA145-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_001363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1079" mass="119319" checksum="9EC26B7096559566" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FC32</accession>
    <name>A0ABY7FC32_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAT3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_000379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR18541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="90" mass="9510" checksum="8F7FBA1D8DEEA891" modified="2025-10-08" version="1" fragment="single">MDIFITQERNGVCVTEVVVHTLKEGQEQTLCTKAGINGTTLNFTVLALTPAEFGSCQKLHCENGGTCVTKLGAASCYCLPGYTGMTCETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCG6</accession>
    <name>A0ABY7FCG6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin--tyrosine ligase</fullName>
            <ecNumber evidence="11">6.3.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_001675</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine + ATP = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17605"/>
            <dbReference type="Rhea" id="RHEA-COMP:16434"/>
            <dbReference type="Rhea" id="RHEA-COMP:16435"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:149554"/>
            <dbReference type="ChEBI" id="CHEBI:149555"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.25" evidence="11"/>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052492">
        <property type="entry name" value="Tubulin-tyrosine_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46570">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46570:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR19837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="222" mass="26021" checksum="459E016E4D2CFBD1" modified="2025-10-08" version="1" fragment="single">MEQYGFIRRDTGSSVYKAASRYLLEARKHDWKKLPANTSSFHLMFGERNKLPFGRLGHDPGRKNLVNYYRGSDILCRKTALVKVFKEYCSLVKYSYPKWLPQSFRILPKNIKQTSIRNSSTTLMKEKPDDRDELLATNVSLTQEEGSSDGIKISDDVHTLLEYVDQQEKAFVIQRYIRNPLLLQGKRKFDISHLTNHCLQKDMSENFGRFEDGNEMFFEEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGT4</accession>
    <name>A0ABY7FGT4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_000284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="288"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="355"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="445"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="478"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="511"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="577"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="613"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="682"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1242"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1072"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="735"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="779"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="854"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="900"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="932"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR18446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1388" mass="156974" checksum="E211FDF261779CB2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGW6</accession>
    <name>A0ABY7FGW6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS4B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_015392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121:SF9">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR21418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="415" mass="46396" checksum="23B1B994407AECC2" modified="2025-10-08" version="1">MDVSDLAKDSKPLSDPLCTDIMIKASEEPLEDHGKFARIKQWFQFENSNQRKNLVTNLVVYINIILLGWTYDQLTTAFPDIQLILNTNVQQTSLIFTMNAVGYMLGSLAMGYCYDEVNHLRRVDGFLCGGRGGGDDATVLSRWGTESRHLTQGTYLSYGLGGVLAPLDTRLFLAPRVPPTAINTIGQDKLGNFSLEWNTTSTPNDYRSHSNISKIPHFLSSSFGESDVRYGVMFITFCAAESKVQSFLFPFVMLQMGWSKFDGAYLLFLLWGFFTAGRSTGVVIARFLSPRKLACLCLCTLIVSYIILAVGGLLEINAIIWTIVPFIGLGLSLVFPTFVVWTHENAIEVKGKMSGFFQFVAAVGFFTDPFYIGYLMEYESPMYMLYIGIPQATCSLIIFISTTLWISSRKVKTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKW5</accession>
    <name>A0ABY7FKW5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CTuncharacterized</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_001694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046054848" evidence="2">
        <location>
            <begin position="21"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="47"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR19856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="246" mass="26117" checksum="7F53136938985C14" modified="2025-10-08" version="1">MKGALAITISALLLVQPFLAAQLPTKTNHKLVTMSMVRPLVEHGRVGIDKCKTCIDFAGQALNELLNIILQGGVVGGCADLCNALASKTSPAIGTVCNILCDIVGIEEFIKIVQNADLDPIYYCELIPACPINDNGDAHFTSFQVSPKSGPQGVFDIDFTYESKNGTGTGEIAIEIDTLAPAGSYNGDIQLKAQPDPNCDPTQGPCEQWLPGTYTVKIAICNGECGSKHPHSAIYDETSATFTITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRP6</accession>
    <name>A0ABY7FRP6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCNA-interacting partner</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">PARP-1 binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">PARP1-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_038567</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PARI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038932">
        <property type="entry name" value="PARPBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32121">
        <property type="entry name" value="PCNA-INTERACTING PARTNER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32121:SF0">
        <property type="entry name" value="PCNA-INTERACTING PARTNER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="509"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR24898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="615" mass="68906" checksum="217006DB2459D4C6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSI0</accession>
    <name>A0ABY7FSI0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DLGP5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_037908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005026">
        <property type="entry name" value="SAPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353:SF1">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03359">
        <property type="entry name" value="GKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="616"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="898"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="620"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="909"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1169"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR24239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1183" mass="130914" checksum="E21DC32B9E9523EA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FW19</accession>
    <name>A0ABY7FW19_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLXB2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013548">
        <property type="entry name" value="Plexin_cytoplasmic_RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF44">
        <property type="entry name" value="PLEXIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08337">
        <property type="entry name" value="Plexin_cytopl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plexin cytoplasmic RasGAP" evidence="1">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="143" mass="16847" checksum="4CCF004CDC499522" modified="2025-10-08" version="1">MLIKTPSILFDINVPSYVSESLDVISQVFIESFSRTEQTVSMESPTQKLIFRNELSKFRSNVQEFYRNVQVNVQKPDELGQYLTHINRSQQETTFNKNAALYRLYDQIKPYTDEILDDMSICQETSRLQLNKKLNDIFSMMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXX3</accession>
    <name>A0ABY7FXX3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMID-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_011437</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.60">
        <property type="entry name" value="Glu-tRNAGln amidotransferase C subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF170">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="28"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR25733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="625" mass="67875" checksum="111D1BB47C919620" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZ26</accession>
    <name>A0ABY7FZ26_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BPAC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="353" mass="38085" checksum="43070722C92960CE" modified="2025-10-08" version="1">MLSGSTRLLVVKPIDNGTEHAVNDTKLAENNTKPAVNNTKPANNDTKPANNDTKPADTDIKPATANNDTKPADIDTQPADNGTKPAVNDTKPANNDTKPVDNDTKHADNDTKPAENDTKSDDNDTKHADNVTKPAVNDTKPAENDTKSDDNDTKHADNDTKPADNDTKSDDNDTKSDDNDTKHADNDTKPADNDTKHADNDTKPADNDTKPADNDIKPPADNDTKSDDNDTKPADNNTKHADNDTKHAENHTKPADNDTKSDDNDTKHADNGTKPAVNDTKPAENDTKSDDNDTKHADNDTKSDDNDTKHADNDTKPADNNTKHADNDTKHADNDTKPADNDIKPVANLHQAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0D3</accession>
    <name>A0ABY7G0D3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF24">
        <property type="entry name" value="THYMIDINE KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="187" mass="21449" checksum="2EE429ABD611F7B3" modified="2025-10-08" version="1">MSCLTGFMNTAHATGDLGKVNTITTNRFGLQEMDVCIEGNIGSGKTTFLQHFQDLRPILEAHLYSDPKRWSFTFQSLVTLTLLKKHDHPQTKPLRVMERSLYSATYCFIENLKNSGLLADVEYNVLTGWFDFLLKQGRVSVDLIVYLQTSPQTCFERIQTRNRPEERNITLSRDEKRPLVDSLDVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2K3</accession>
    <name>A0ABY7G2K3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Geranylgeranyl transferase type-1 subunit beta</fullName>
            <ecNumber evidence="4">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Geranylgeranyl transferase type I subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_014382</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.59" evidence="4"/>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd02895">
        <property type="entry name" value="GGTase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041960">
        <property type="entry name" value="GGTase_I_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="13">
        <location>
            <begin position="9"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR28678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="356" mass="39869" checksum="D398FBDEAF6C1AFE" modified="2025-10-08" version="1">MAAPMKDDFLRDKHVKFFVRCLQVLPGRYSSLDTSRMTIAFFALSGLDMLDALRVVEKEKSSMIEWIYSLQVLPNKEGSNSTLCGFRGSATLGNPFDAKKASEKSIPYDGSHVAMTYTALATLLILGDDLIRVDRQAVLTALRTLQLPDGSFHPVSEPSENDMRFVYCAACVCYILDDWQGMDTDKASQYIVKSLSYEGGIGQGPDLEAHGGSTFCAVASLKLMDRLHNDLTDGQMNNLQRWCLFRQLSGFQGRPNKPVDTCYSFWVGATLQLLDCYKFVNCDCNRAYLMDTQQHITGGFSKWPSHNPDALHAYFGICGLSLMQEPGVLQMHAALNISQRAADRLVDIHRRWRDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2L3</accession>
    <name>A0ABY7G2L3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MITF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_011260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MiT/TFE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd11397">
        <property type="entry name" value="bHLHzip_MITF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031867">
        <property type="entry name" value="MiT/TFE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776:SF2">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15951">
        <property type="entry name" value="MITF_TFEB_C_3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="274"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="320"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR25556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="359" mass="41062" checksum="C9F70A774CB54A6F" modified="2025-10-08" version="1">MVYSDLMLDRKVLKFLVCVKEDGKYRRAPKTTEIKNASTPMRANLKLHLMRAQAQEDEKRERQYSQSHKVSHIPSNGIDVPPQASPSQAPDISVPPQVLEVKTKLENPTKYFMMQKQKTQIQSYLSESHNSAPSAVHSMPNYRVVSSADMSMQLQPHCGSAPVDPDSPLSVGMSSTATSMSEVESLLNDLQDLDQVDLNQDDDLKFITPSLVQMSSSTIPSSNDYMFTPISETTTTAQSAPSMLPGQRIMTPPYLTEDDARMWAKERQKKDNHNMIERRRRFNINDRIKELGTLLPKSIDPSWMFCSDLRQNKGSILKASVDYIRKLRRDQDRLRQLEEKQRQTEMQNRKMMLRVQAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4M7</accession>
    <name>A0ABY7G4M7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_002971</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="170"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR29403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="260" mass="29885" checksum="B104AE2CF7FA5747" modified="2025-10-08" version="1" fragment="single">MFENVFKAQYMNTVSPRLECNPYACIMSTILRKQEIPFVFPTVVPILSMDTTKESGEQFADDGNNNASHDVLAMAGNIREAYSNDKKDLHFLKHDVKGQLRELEQQMTNLIENLTTNVKQSEQIDLRLNETEAKLNESISSTFRQNEEKLQRSNIEITNDNYYYPCAKDIRLANAHQYRNGEIVGRLEASVTMMNGAHCATICIYTLNVNVVCRTFGFRECDYIVTSYCWRMGSKKKWMDNVKCLGTESSILECPHDGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6Y4</accession>
    <name>A0ABY7G6Y4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_014505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047273422" evidence="2">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR28801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="76" mass="8074" checksum="88F6ED0FADE47692" modified="2025-10-08" version="1" fragment="single">TGDMRLLLAALFCGVVVGAYSKSVADNDLRKLLKLLTERKNVDARQGSGADTPSTVPPSNPFPMPNMPVEPSTDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G859</accession>
    <name>A0ABY7G859_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="67" mass="7576" checksum="EEB067455C9BDE57" modified="2025-10-08" version="1">MVPKQKRYFEDDNEERDKHHTFIEPTKDPTEARISVHGNIPCHTSANSSLCSCLGLCSEPFKGLKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G867</accession>
    <name>A0ABY7G867_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OAS2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_013165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-5A synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd05400">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.20">
        <property type="entry name" value="2'-5'-oligoadenylate synthetase 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018952">
        <property type="entry name" value="2-5-oligoAdlate_synth_1_dom2/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006116">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11258">
        <property type="entry name" value="2-5 OLIGOADENYLATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11258:SF11">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10421">
        <property type="entry name" value="OAS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18144">
        <property type="entry name" value="SMODS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50152">
        <property type="entry name" value="25A_SYNTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR27461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="379" mass="42670" checksum="1514203BD10D268A" modified="2025-10-08" version="1" fragment="single">CPFSCGKGPFGNKARRRHVHKFHGPLPNICDVCKEPFLSERALQMHEEDKHSGTSHRAHEPFKVERHPIPIADLYLVEDLDVTIANVIQPDKKFLSKTRRAVDKLVKLIQHNLPTELTAARVFKGGSLGKGTAVKGKSDIDLIVMMSNISEVSDLTSKMPKILQEMETSLQTFAGVSVVGNSKHSVQITFNGLSVDILPTLNVKNKRSLKRLYRNMTDPHSLHTKEFYSATLCQLQTALVGAVPTKVKSLILLIKYWNKEKVKPVVLSRTPTSYVYEIIILDRWVKADKPKLFDMRRAAHDVLTALVHHKDLQVLTAGLAKYSKDTAQIRHDTYIMDPCNPTNDLYNSRNWNWDGVASEAKCWLKSSVFDGVSGTTGHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9D6</accession>
    <name>A0ABY7G9D6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CLCA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013642">
        <property type="entry name" value="CLCA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041940">
        <property type="entry name" value="choice_anch_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF177">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08434">
        <property type="entry name" value="CLCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="194"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="740" mass="80892" checksum="45C1DCC90A7DA66C" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9V5</accession>
    <name>A0ABY7G9V5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="171" mass="19688" checksum="1CBF948AF4464AC8" modified="2025-10-08" version="1">MGDFSDKSSEAKRFRIPVLCLLEYIKEAQEISSRQPPKRFRKPITEIGLKFEERSLSTTRTVMDKQEDARAASEHERIRRLMLEGVIDAPNDHRAIVYGDHNKRHGKKKRKKGKRQEVETQVGLQSSSRPSSTKSSLRGRTPDSRSQGKRVNIEEKENEVYSTSNEGKKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBE8</accession>
    <name>A0ABY7GBE8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_033456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="52"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="109"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="163"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="219"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="272"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="325"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR30914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1024" mass="117576" checksum="A0C3FB25B94BE0E9" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBS1</accession>
    <name>A0ABY7GBS1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15550" checksum="DCE8F2AB30AB3E6C" modified="2025-10-08" version="1" fragment="single">MVNLVIRKYCCYPGKTPLASSCDRCQRAKGDPTASPTLSNPLPIRFHIDLIGPTTKKFEWAFSFLVCVCNPTRWVEVFPIRAQSASEFAGVLHGEIFWRYGASNVIVTMQFVRFTAGYNPQASGCVERQNATVIKTIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GCB9</accession>
    <name>A0ABY7GCB9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_033756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="201" mass="24365" checksum="02978F65C3C7C792" modified="2025-10-08" version="1">MVTVNMGPRQYQYRLMVIVNTGPRQSQYRLMVTVNMGPRQYQYRLMVTVNMGPRQYQYRLMVTVNTGPRQYQYRLMVTVNMGPRPYQYRLMVTVNTGPRQYQYRLMVTVNMSPRQYQYRLMVTVNTGPRQYQYRLMVTVNTGPRQYQYRLMMTVNTGPRPYQYRLMVTVNTGPRQYQYRLMVTVNMGPRQYQYRLMIKSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GE87</accession>
    <name>A0ABY7GE87_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LolA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_033988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058831">
        <property type="entry name" value="LolA-like_dom_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36902">
        <property type="entry name" value="ENRICHED IN SURFACE-LABELED PROTEOME PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36902:SF1">
        <property type="entry name" value="ENRICHED IN SURFACE-LABELED PROTEOME PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25898">
        <property type="entry name" value="LolA_2nd_metazoa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="LolA-like" evidence="2">
        <location>
            <begin position="46"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="LolA-like" evidence="2">
        <location>
            <begin position="258"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR31446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="564" mass="62863" checksum="8D5165B33E06DFC2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GEB0</accession>
    <name>A0ABY7GEB0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">YEEE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_003099</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp_TsuA/YedE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574:SF1">
        <property type="entry name" value="SULPHUR TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR29531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="416" mass="44008" checksum="E06CCC1D84D02FA9" modified="2025-10-08" version="1">MSARLRNSFIKSTGEYAEENSVTKNESEKRTIKSEKYGSRLGMEEKAGPNSFSDIAEIGDGETTGKVNNSRTSENDEYSASASKYDADSGNGAEEKTKFTKEVPGVFGIIIRLILCLLCGIVFGFCLGRGRAVLEYIACFTHKGIVTSAIGAFVLGCGMTLSGACPGMILAQIGSWVPNSIFTAIGCLVGALTYGMAAPVNQTLKLPFIAVALPMAVMLLVAIILLEVYWDYSKDLEYIGRKLPPYSNIVTAVAWMPSVTGAIIGLIQLPLVFTVHDTMGGSSAYVTIVSQWVVTKRLQEMFPYLAAKRCGLGNWWQVIYVSGAVLGAALASVASDTMATSHGVNLPTSIIGGILMLWGARFASGCTSGHGLSGMGLLAWLSFVAVPCMFAGGIVTAFSMKATGDIDDYVTTTGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAU6</accession>
    <name>A0ABY7DAU6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NEK10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_006652</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF92">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="432"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="733"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="948"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="735"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="764"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="949"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="978"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="999"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1021"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1034"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ94181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1137" mass="126110" checksum="8FB31C8097731E45" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DC06</accession>
    <name>A0ABY7DC06_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="514" mass="58251" checksum="E60A5F6D85DF4893" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DD86</accession>
    <name>A0ABY7DD86_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCR4-NOT transcription complex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cell differentiation protein RQCD1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_007037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ94566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="163" mass="18384" checksum="9B65F035E265F560" modified="2025-10-08" version="1">MKRRQFAMTYKDRVSHDEPWSCSPTSGSGSLMTGSFMSQAEREKVYQWIGELTSPDTRENALQELSKKRDVVPDLAPMLWHSFGTVAALLQGIVHVYPAITPPHLTAHQSNRVCNALALLQCVASHPETHSAFLTEALRQCLTDQLKDRPFVNCLKNDNFTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDU0</accession>
    <name>A0ABY7DDU0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="132" mass="14411" checksum="9C376B5DEA5A77C1" modified="2025-10-08" version="1">MPYRFGIPMLKTGVSVGRYPNRKPHPSGAPPPRNLAHKPHPLGASAVGTRQRGVCSGSDSAYVTEDEGGRKPHRKESQKHHLNGCNESHLNGCNESHLNGCNESHLNGCNESHLNGCNESHLNGCNESHLYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DE25</accession>
    <name>A0ABY7DE25_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_007056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="735"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ94585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="840" mass="94710" checksum="37BDCD28DC5BFD90" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DED1</accession>
    <name>A0ABY7DED1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SRCR1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_028056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRCR" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="3">
        <location>
            <begin position="70"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ95366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="207" mass="23036" checksum="EFF6821CA42CF7FF" modified="2025-10-08" version="1">MHEHRTATIYERLKYGQGSGSLIVEDLNCTGTEDDLDECESFPWFENSSQPPCNNHLYDVGINCRPKTPIRLVNGTKATNYSGRVEIEYEGEWGPICDMSFDANDAKVICRMLGYNTESASYHGNAYYGTGNSRAIVSNLYCLGHEQDISECNAGYTWSQIHPHCSAVNNLAVQCNTPVRVNNAWTLYLGVVEVYIRGSWRGGSGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGP8</accession>
    <name>A0ABY7DGP8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SARAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_028289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd21886">
        <property type="entry name" value="SARAH_RASSF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033614">
        <property type="entry name" value="RASSF1-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738:SF15">
        <property type="entry name" value="LD40758P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738">
        <property type="entry name" value="RASSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SARAH" evidence="3">
        <location>
            <begin position="472"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ95599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="526" mass="57398" checksum="91CC0A95AFDB30C6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIB6</accession>
    <name>A0ABY7DIB6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PKD2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_028919</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF194">
        <property type="entry name" value="LOCATION OF VULVA DEFECTIVE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="673"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="749"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="790"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1030"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1061"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1094"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1146"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1187"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1249"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="11">
        <location>
            <begin position="477"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1347"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1356"/>
            <end position="1366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAQ96229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1366" mass="155781" checksum="4FE00093F5E082E8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIG2</accession>
    <name>A0ABY7DIG2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RS14B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_030172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ97482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="402" mass="42636" checksum="7B83E3F8E7389A33" modified="2025-10-08" version="1">MFPSTSKTMICSEQEIGCPLLISVFIISEFAGLARHKEPPLMDRAPHGRLVDHIACRSCSEHEIGCPLFISVFIITESACPARHEEPPLMDRAPHGRLWMEYAGPQVALDGHRIVPGKHLGSLNGNVVQQERAHYSICNTLGKLLQFSPKLSLIPGAGGTKGVTVPTGATVAPRSLMLAPHPTYQVVYLSTTGNNFGINQTIIACNHIHTTPTSQTEGIKYEAGEEARGSMLSDAGAAVTAGSGAQLSGKLQNVILSCSGSGMGCGMAPRKGKVQKTEEQITLGPQVKEGENVFGVAHIFASFNDTFVHVTDLSGKETIARVTGGMKVKADRDEASPYAAMLAAQDVAEKCKNLGITALHIKLRATGGNRTKTPGPGAQSALRALARSGMKIGRIDIDLEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIT5</accession>
    <name>A0ABY7DIT5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PLAL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_029305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF34">
        <property type="entry name" value="PR_SET DOMAIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="854"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="882"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="548"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="649"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="782"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="901"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="785"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="913"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ96615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="935" mass="103229" checksum="09D21A776BD9D1F0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJW0</accession>
    <name>A0ABY7DJW0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SYT15-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF234">
        <property type="entry name" value="SYNAPTOTAGMIN-15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="105" mass="11773" checksum="5C6A4D70CACFE051" modified="2025-10-08" version="1">MEKNQRVTIGVEGRSFTCNGNAQIDSYVKVHLMVQNKLVMGKKTEIIKKNSNPVFNESFTFKLPVVSLDTANITITAMKHQTGYKDKMIGKVTIGSFMFARGKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DK02</accession>
    <name>A0ABY7DK02_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="22">NAC3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">MAR_029710</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">MELC-2E11</strain>
            <tissue evidence="22">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:69955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051171">
        <property type="entry name" value="CaCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004836">
        <property type="entry name" value="Na_Ca_Ex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF76">
        <property type="entry name" value="CALX-BETA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01259">
        <property type="entry name" value="NACAEXCHNGR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="730"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="761"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="801"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="21">
        <location>
            <begin position="340"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="21">
        <location>
            <begin position="464"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="WAQ97020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="830" mass="91513" checksum="8F83A47625DF487C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DK94</accession>
    <name>A0ABY7DK94_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAZ1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="586" mass="70865" checksum="4BF28A4798A5D223" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKH2</accession>
    <name>A0ABY7DKH2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SRA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_022555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009917">
        <property type="entry name" value="SRA1/Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040243">
        <property type="entry name" value="Steroid_recept_RNA_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18834">
        <property type="entry name" value="STEROID RECEPTOR RNA ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18834:SF2">
        <property type="entry name" value="STEROID RECEPTOR RNA ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRA1/Sec31" evidence="2">
        <location>
            <begin position="163"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ98182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="395" mass="42769" checksum="58BA866EA40B6BF2" modified="2025-10-08" version="1">MSDSRVRPGNPDRVWNDPPMFNYTGSPSGGQPRRALNKRVAFPMSSNSTAPGHAVLKPSAGPPILNPVLPADIQGPPMAPQQAPVPIGLRDTPLGNQAPPSTQIQLLPPSTDVSMPQTVPVLVPLLVPSTQPLLVDSEKVVEPVPSSLDNERLEDLIARLSVTAESDLLKMTVKKLNEVLEGYSSILTKKVYEDITRKLEILQEKWPSLSETVKVRVVQLALALSSGETDKASHLQLALVVDHIAEVNQWVMGVKRLIQQQQLANKEKEIISENRMAALGEEDSSNQSDPHDTEKDEANNQSDVNQSGNSDNQSGTIDIQSDIADNQSQAGSDPVDISDSSKLDCVGNQTELKSCQNFDHTNNESITEQSNVENSEEGTNTSNQTEEASNVDNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKX4</accession>
    <name>A0ABY7DKX4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ACH1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_022705</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Synaptic cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="35"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAQ98332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="211" mass="24675" checksum="4BB8E0FB6CBFB470" modified="2025-10-08" version="1">MATERIPYLILLTRCLVILIMCNLFGYSDGNDDAKRLYHDLLIQNKYNKLIRPIGNNTNKPLMVRMGIRLSQIIDVDELNQVMTTNVWLRQEWYDFKLTWHPVEYGGVDRLYVPSELIWLPDIVLYNKITCLQWYPEVNEKNKTNSSCRPKTYCCLLLSYSTSAIEVDLTYECSTNPESRVIITSRIDIRDLNDSGECNILEVTENNHNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPY5</accession>
    <name>A0ABY7DPY5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CO6A4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="165"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="410" mass="44347" checksum="C0333C390A7846C4" modified="2025-10-08" version="1" fragment="single">MRTFVIDIVDFLDIGSDLTKVAVITFSNYPVRRLSLDAFTDKQALINAINQIPYYPETDKAFDYLLAHGLEGDRKGAPDLAIVVTDGYSSAPDLTKIAADKVKQQGIGVFAIGVGSEVQMSELNYISSDPDSNFVYFVSNFTQLSSIENAVAKSTCEACVAKVADVVFVVDTSGSVGGENFLKVKNFIKETINVFDIGSQYTRIGVITFSTAPTLQFNLTSYSTKADILAAVDRIPYTQGSTDTAAAMEMLRQEGFTNERTNDPNIAIAQLAKESDNVTLIAIGIGNETDSDELEGLASTDNMNKSLVYQVGDFEALKTLEKVVATVACGLVIVTPPSRIVTMPPVTTNSSDCFDVEACSRYGQDDCKDYHPYMAKNCRLFCGFCQGGGTLPTDSPHPVTQIAPTRQTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQ53</accession>
    <name>A0ABY7DQ53_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_023062</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF126">
        <property type="entry name" value="PROTOCADHERIN FAT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="48"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ98689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="190" mass="21070" checksum="0A7ABB763A7BA357" modified="2025-10-08" version="1" fragment="single">TISTSGTLDRETIARYTLNVTANDGLQTSHCMVRINVNDVNDNAPKFDQSFYSFDIPEDTAIGTTVGSVRADDLDVGLNGDVLYSLTAGWGNDTFELDPVKGTFKLLRVLDFEETWDFVLMLWNSLYTLQVLAYDAGTEPQTSSILVFFNVKDTNDHIPEFEQGEYNAAVYENVTIGTSVLQVEALDIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DS41</accession>
    <name>A0ABY7DS41_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CALL3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_024059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ99686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="146" mass="16106" checksum="A5D0EC316B9E5B50" modified="2025-10-08" version="1" fragment="single">MSQTLSDTLKKAIQDAFGKVAGGKTDRLRKKGVRAVLQLIGQNPTPAEMDGYFKDSGVHEVDRDSIGNFIESHVPLKSQNTINDDIAEAFAKFDTNDAFVITKADFREILTQLGNERLTDAEAEAILDCLDKSSEHVNVSETIQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTN1</accession>
    <name>A0ABY7DTN1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="129" mass="14528" checksum="2A67E3C63D26F67C" modified="2025-10-08" version="1" fragment="single">MVPVLVLIPHLISPNIKTLRGKPSAYAHIGNLLQQDHTSPNVFWNCIKPKKEDNFSVSSLKKERLAFTDGKQKAEILNDQFNSVFTKEHMSPKPHMAPGQGKIHTILLKLASAELYQDLAKLFQLSLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUG7</accession>
    <name>A0ABY7DUG7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUD15-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd04678">
        <property type="entry name" value="NUDIX_MTH2_Nudt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099">
        <property type="entry name" value="8-OXO-DGTP DIPHOSPHATES NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099:SF5">
        <property type="entry name" value="NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="222" mass="24941" checksum="52A05B330599AB25" modified="2025-10-08" version="1" fragment="single">MSAPFDKQKRPKVGIGVLVTSTDHTGCVLVGKRKGNVAGEGMFALPVGHLEFGDYISQSAQDNFVISFVSREPRETWEECAERELLEETGLVLTGIRFVTAVNAVEKDTDYHYITLFMAGQVDLAQRREPVGNGLLGTASLTVLSSSVLLGSSERWVKTWEECTIRETKEETGLQLKNVQFYHVCNGLDLDHDYHYLELYMIGEVDETFQREPVNMEPDKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWA0</accession>
    <name>A0ABY7DWA0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_007887</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015151">
        <property type="entry name" value="B-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013037">
        <property type="entry name" value="Clathrin_b-adaptin_app_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09066">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01020">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="7">
        <location>
            <begin position="642"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-adaptin appendage C-terminal subdomain" evidence="8">
        <location>
            <begin position="725"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR01329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="836" mass="92532" checksum="0309BF2BC453F358" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWH0</accession>
    <name>A0ABY7DWH0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="91" mass="10853" checksum="1027E6EC6DB84634" modified="2025-10-08" version="1">MHFLYRVCWRKGVCRERPCQGRRRARAGLAEVTLVCRIMFAQFAIRAQYFCRHLGVRCARARAHCQLYFQNKRRCQARARMRVPGQTVRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWU1</accession>
    <name>A0ABY7DWU1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTBD6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_008067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF9">
        <property type="entry name" value="LUTE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045386809" evidence="1">
        <location>
            <begin position="36"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="BACK" evidence="2">
        <location>
            <begin position="137"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR01509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="474" mass="53222" checksum="F1E64F312286E830" modified="2025-10-08" version="1">MSVFAEGNSNISPGIWPHSGHVVFVLLADLLNAVADEVLDVVLLSAVKQWQHSISSQIDLVTIHVPAEKPCINELREAMIICKKSKIYDKYLYTGELKIEGISVDKVLSLAERYGARELIKQLVAIQLETMDAEMFCPFVRKNENHMTELIKHKCLEYVFNQPFKVFQSGTFSILPRSFLKEILEHEMLVIDEEVLCTAVLLWVSKECETAHMEVNGKNQRKVLGDMIYLIRFPLLSQDYFTENISEKGLLTEHEEVQLLKYFLKAKNAIQSLKFETKKRTAPKVPFKFSPHLENGPTVGGLHTTGSRPILATSETEKQGYVSRFTERGIGWGYRSNRKDAIAFTVSGDIILKYIDIYGTCKDNGTLDVTVALMDTKKQVSETDMKVPCQLTNASGLYEVGIENDTGSYGVHLKAGTEYHLILTINGGNTFYGKNGKAKVFADGIEFNFMTSQYSTNNTNTNIGQIAALKFTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZ23</accession>
    <name>A0ABY7DZ23_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_008473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR01915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="502" mass="56165" checksum="54C8A2C231D9458A" modified="2025-10-08" version="1" fragment="single">TFGTWKTSLDRGRPTGEERRERDGEWRIYYLDHSQLNSTLKKLTHEAVLKSLKHTIDEKCTQAIQLTERSCDSDSVITNVTLKDAPYEMQDTTIVTTMNQFGDVIDGSLVRGKIKNTNISNGTRYLKILNCIPILPPSIEIGKFKIRLFADNNRTRCKICQKTDHPYFKCPDRFQRPRQSYSEAVRLKSIKACFNCKENDHLRKDCPYDVICHYCKEEGHTQAECPMEKSGNYAAEIMEGQRSLNVSGGPYSSDDDSTVVPGSVRETLNIPVSASDPLPSLKEPCPPEVTSQPIRAGKSKVHIILGDSNCARIHVKDPDIRNVSFSGISITSVDSLISKVKIGDNEAVASVVIHLGTNDMRNRSSDDIIADTNRALITVAETWPDVPVAFSSILPHKGTNPLVKSMNSAAKQINKNILRLCQSKNNFHYLDNDHSFNKFNKSFYDPRDPTGVHVSDEGAEELYANFLAFVFDGESDELVEVPSTPGSPPHRRRQTGCKNKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZE4</accession>
    <name>A0ABY7DZE4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">T132B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_008604</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM132 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031437">
        <property type="entry name" value="Ig_TMEM132_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055423">
        <property type="entry name" value="Ig_TMEM132_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055424">
        <property type="entry name" value="Ig_TMEM132_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026307">
        <property type="entry name" value="TMEM132"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031436">
        <property type="entry name" value="TMEM132_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13388">
        <property type="entry name" value="DETONATOR, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13388:SF11">
        <property type="entry name" value="DETONATOR, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16070">
        <property type="entry name" value="Ig_TMEM132_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23486">
        <property type="entry name" value="Ig_TMEM132_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23487">
        <property type="entry name" value="Ig_TMEM132_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15706">
        <property type="entry name" value="TMEM132_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein family 132 fourth" evidence="9">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 fifth" evidence="10">
        <location>
            <begin position="95"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 sixth" evidence="11">
        <location>
            <begin position="230"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 C-terminal" evidence="8">
        <location>
            <begin position="455"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="535"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR02046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="647" mass="72841" checksum="502B3716C8B8403F" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E318</accession>
    <name>A0ABY7E318_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="57102" checksum="2673FCF056C34D52" modified="2025-10-08" version="1">MYPGNTEKFQKAFARATKNPYGYLFVGLKPFTSENDRLRYDLTWIDTQTGNKTRLISQMPERQNRPDITSHSHAGRCETIKEMRVPELDHSSVGFQGVHIDEEQENTMADKAKACDDCGLLFDSGHDVQRHVKSGWCSENREPPAKRAKTEEDENEMDDDLGDNKGYRHTWDLAQSCSQNKFNKLYDQFIDDGENEYDATDMAEKRMQPYKEKNFFDIYQTLLETYWLPLMTNATHLEIVQLINEFCSKEVSLPSAVKRVLKKKKIAFEDLVDLDDSEESEEDESEEEDMDSQEEFQANKVQSLMRKYDVRYFPTQNETKASTSVETILTIKRRLYRYFTHNDSYSYLPVLQDIAYSYNRTYYRTIGMPTSDVTDTNQEVQLATYVSQNPKYAKQDTKLKPFKFTVGNYVRISHLRNIHKRYHRGTLPIYRLRDLQDEEIKRTFDESELQKITFDSDQTFKIDKIEKTKGKGKHKQYFVKWKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3Y1</accession>
    <name>A0ABY7E3Y1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR03677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="316" mass="35778" checksum="1A16A34C75DDF6CB" modified="2025-10-08" version="1">MITNERYLNLHRADDDCNRDQEAGIPNDQLRIALEPEAASVWCQVCTDDKITKLSDAGTKYMVVDLGGGTADITVHEKLVDGRLRELHRASGGEWGGNRVEQSYIDCLTAMVGHEVMDEFRREHTGDYMTLLMDLETKKRTVTASLEGKVTLTVPLTFSECCHKHDINIQDRINKSPFKDKMKWTRDRFRIDKTGEHDPGRKTKYCGNDVCQQYFWKMVEIGDDLPLGKEVSEEIPGLSAEQTGAHIKVFCSASTDTKYVDEDTCTQLGELIVPLPDSSDPKDKNIKVSFIFGDTELKVWVQIIKTGEELERNVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E460</accession>
    <name>A0ABY7E460_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TAF15-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_010310</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM TET family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd12534">
        <property type="entry name" value="RRM_SARFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034870">
        <property type="entry name" value="TET_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23238">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="261"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="12">
        <location>
            <begin position="381"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="18"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR03752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1282" mass="131283" checksum="E3ADD82F7755C4C4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E502</accession>
    <name>A0ABY7E502_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED19</name>
        <name evidence="8" type="ORF">MAR_010174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019403">
        <property type="entry name" value="Mediator_Med19_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22536">
        <property type="entry name" value="LUNG CANCER METASTASIS-RELATED LCMR1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22536:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10278">
        <property type="entry name" value="Med19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR03616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="216" mass="24261" checksum="F56095A2D2688F4D" modified="2025-10-08" version="1">MNDQMRRPEQISPKSSPRGSISPAYQRPDSSGTLKTTISLGKVPSVIHSGPFYLMKEMPISTAEKTELTGCTNLIDYHGLEHTYNKFCNKKGKEELSSFLPHLPGYIDAPGIQDNSSLHSLIEKPPITGKEMNLLSNTALASFRLHPGPLPEQYKFMSQMPTKKKHKHKRKRESTANGSIPESAEESSKEKEKKDSKKRNKKKKKKGREKDEDPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5K4</accession>
    <name>A0ABY7E5K4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_020684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="194"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR05315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="288" mass="31374" checksum="0BE05B8AE7D6AD3E" modified="2025-10-08" version="1">MSVTLTPKANPISVIENTPQLFKCLTSICRPKANVTWYLGSEQLTSATVSSPSQDVTTSTLNFTSQRKHQNMTIHRQESNGGQLRTSDKPTINVIYGPSQIVCKLDPPDPPSCRVGSSARSSNIVSAIQGHTITISCSCDSNPPSIYSWSVTGVSTPTSGQSFILLVQKSTTITLTMENSMQFTNGKNEKGRIPPVVKPLKNITVLEKSQVNVACEVTASVPNKTIFRWENISDMTSVATEQTLGIANISRAQGGYYRCNATNFMEPTGYDSTVGNSYNTVYIDMRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E840</accession>
    <name>A0ABY7E840_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_009869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR03311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13727" checksum="550ABF9DC7501C30" modified="2025-10-08" version="1">MSSKAPLIIVINLGGNDLSSMELGEFKAHIFSDFKYIRSVFPTALLAWFDILPRLHWREVDDASAKPMDLKRKRANRLGRQAWSDSWLDQLIAERLVSTLLTVSTCPKLVVGCTLSHCRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E861</accession>
    <name>A0ABY7E861_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CHIN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_021556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd20806">
        <property type="entry name" value="C1_CHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10352">
        <property type="entry name" value="SH2_a2chimerin_b2chimerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035840">
        <property type="entry name" value="Chimaerin_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051854">
        <property type="entry name" value="Rho-type_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075">
        <property type="entry name" value="CHIMERIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075:SF2">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 5A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="68"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="6">
        <location>
            <begin position="227"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR06187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="435" mass="49751" checksum="9B7552C2F4DC7D1B" modified="2025-10-08" version="1">MTTKENPVPRPRYYNMVYHRTSMNADSSDNQLPTWKTYLYQLQNEAPKPKLLKCTKDQPNRPTYYGDEYHGLILREEAEDILAQGGDGSYLVRRSDRAPQAFTLAIRFDNQTKNYKLYYDGLHYVGEKRFETVEQLVEDGLIHFYIESRAADYIASLSDTSNYAQSPYLAYSVKKKRLQKSRKNAAHHRVDASQLVTGQQELVSSTTDLDEEDGTDMDVDVSIFEKPHVFKTQNFIGLHWCDFCANFMWGLIAQGSKCQDCGFEAHKKCSERVPNDCMPDIKFVKSIFGADLTTVIKALKTPLPLVVERCMEAEGLYRVAGLHDDVEEIRMSFDRDCEKADITSGKYEDINTITNQESKKDKVTFLREGLAMLPPAHYQTLKYLNMMTTDNLAIVFAPTLMRSPDSDPMLNLMSVGAEQKAVEMLLSCNKELFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EA07</accession>
    <name>A0ABY7EA07_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CLYBL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_016831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040186">
        <property type="entry name" value="Citramalyl-CoA_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11105:SF0">
        <property type="entry name" value="CITRAMALYL-COA LYASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11105">
        <property type="entry name" value="CITRATE LYASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046447763" evidence="2">
        <location>
            <begin position="28"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="3">
        <location>
            <begin position="235"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR06873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="942" mass="103896" checksum="AC4568BA7277CFA1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAP3</accession>
    <name>A0ABY7EAP3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGRL3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_016873</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008077">
        <property type="entry name" value="GPCR_2_brain_angio_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF347">
        <property type="entry name" value="FI21270P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16489">
        <property type="entry name" value="GAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01694">
        <property type="entry name" value="BAIPRECURSOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="10">
        <location>
            <begin position="146"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="11">
        <location>
            <begin position="312"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR06915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="625" mass="69030" checksum="B3BA78F6AA5CD74D" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EC05</accession>
    <name>A0ABY7EC05_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPDLY-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_022023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051149">
        <property type="entry name" value="Spindly/BICDR_Dynein_Adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32123">
        <property type="entry name" value="BICD FAMILY-LIKE CARGO ADAPTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32123:SF9">
        <property type="entry name" value="PROTEIN SPINDLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="563"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="125"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="182"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="261"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="469"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="564"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR06654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="660" mass="76201" checksum="FB48E72E7546E09F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDA2</accession>
    <name>A0ABY7EDA2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SC6A7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_017960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR08002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="156" mass="17052" checksum="05135271500268A7" modified="2025-10-08" version="1">MNAAEKKLEFQQSNGMDSNAVEIGAGCENADVNHDVALDATVSNVRATHNGDYLSGSNDSTGPEVVRETWSGRFEFLLSVVGYAVGLGNIWRFPYFVKRNGGVSCGGPLYYIEVCFAQFSGKSPVNVWDICPLFREICQACPTKSCLIQAHRLDMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDR9</accession>
    <name>A0ABY7EDR9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GLBL2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_021913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="4">
        <location>
            <begin position="56"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="5">
        <location>
            <begin position="283"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="6">
        <location>
            <begin position="433"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR06544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="511" mass="58624" checksum="86D277AEE7084F3E" modified="2025-10-08" version="1">MESLFGCSRCSMSDSREWLGCDVDGFPSNVNATYVSWNLHEESPGNFNFEGILNISWLLRDPNMKVRSNYLGYQKAVERFFNKLIPLITDLQYSNGGPIIAVQIENEFGSYSSEVEHLLFVKQLLVKNGIKELVFVSDGIVQDKTGFQVAPFYDESLPTANFMKYKLGEPLFQQIRSISPDFPLMVMEFWAGWFDHWGKAHANPSTKSHDYVAPISEYGEITPKYEIIRALIRKYEILPKAKPDLPQLPAPVSTANYGKVVIDEFLQLEDMMVPVKPIKLEHPVTMEKLDLGEGRGQNFGFVVYRVIIKHGKNLKFTKPARDRVQVLLNGIQVGVFTWMSSFWQTTFPVDKVFDENILDIIVEHQGRVNYVHQGFNRFNEEHKGLAGDVLLDDKPVTGNWSVYPLPFTKEQISKFEESKKWKPYANWKGVSSLYRGSLFINGTPRDTFVNMKGWKKGIVSINGFNLGQMDCDLMHLDYCLDQEDFFSGEKNKMTSKKTFVPPLQIIKTQYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFS7</accession>
    <name>A0ABY7EFS7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="146" mass="16019" checksum="826A2810CD5E2F51" modified="2025-10-08" version="1" fragment="single">MDIESEDVDEDGMIHENDFDSDNSLPQAALVEEYPTSNPYSTVPMYLEPLNTDEIERIPSPEIPNSSEISHQPVRHPTDVNQQTAETYDRPTYEGATNDRYEQSQPASADALGVSLCYKSVGIQESRAGGDIDNPTQAGINETNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGQ6</accession>
    <name>A0ABY7EGQ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PTPRH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_018075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045976048" evidence="2">
        <location>
            <begin position="30"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="122"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="251"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR08117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="497" mass="55592" checksum="F0F452D5C0EC45F1" modified="2025-10-08" version="1">MWCLLRTMETVHYFALLVNLVSLTRSCHGLGQTCTVNPSNCTCTGEVCLGSNTCVCDSEHYTANGGCTEIAQLQVTSITFSQVDTTSMIVSWTPPSGKSGFIYDYKVQWRSNDNTIVGEPQAPPVVKPVVDIGKTSFNVSWSLIGPRPGQVTYTVILTADMGADSKKYNVTGYLNNSWIADGLEEYWNYTVSVKAITNVGCAKTSDITQKYRTLHSAPGAVTDFEAVKAEQRSDNFHKMTIRWKAPSLLERNSDIKEYVLKHNVGNIATNSGVGGELKTMSFTSETGDGFYSQEFDGCWPEKDYKLCFNPTIDKVNQFWTMIFEEAVYTIVMFAESKAHKKESRYWPSDFNEPTNYGHVDLEVTYLNTHNAYTHMKINICNRLTTRTVNHFQCAPVSTFSPDGFVYFVKCVRSNVKTGRILLQSSKGLASTVPFVVLDTCLQQLSDGALAEKVDVYKMLELFIFTHDCVQRLGTGDYEPLQNTAQIESVYQTLQVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGW8</accession>
    <name>A0ABY7EGW8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="179" mass="17899" checksum="D5D8FD22DD2E4699" modified="2025-10-08" version="1">MPSGSGSYGHGSAGYGKQGFGGYGQGSMSYGIGKQGFGGYGQGSMSYGIGKQGFGSYGQGSTSYGIGKQGFGGYGQGSMSYGIGKQGFGGYGQGSTSYGITKRGFGGYGQGSMSYGIGKQGFGGYGQGSMSYGLGKQGFGSYGQGSKSYGHGGQSYGGYGQDKSLQRSSGRDVVIDIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIC1</accession>
    <name>A0ABY7EIC1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="94" mass="10494" checksum="7910E83226808627" modified="2025-10-08" version="1">MTHKTEPKVSRFCSVLGCAFNLTSTTTALLGLFLPFWVYVNDVLETNTYDLTENTNVIYNYDWEKMTLVSVASGAGLNALSFLLVVLHSKLNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIG5</accession>
    <name>A0ABY7EIG5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VP13D-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_018690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF141">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="2639"/>
            <end position="2679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="667"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="943"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2008"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2086"/>
            <end position="2143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2501"/>
            <end position="2529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="943"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2008"/>
            <end position="2018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2029"/>
            <end position="2051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2111"/>
            <end position="2126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2501"/>
            <end position="2512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2513"/>
            <end position="2527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR08732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2697" mass="302025" checksum="1F70F5330A2D20A0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EK38</accession>
    <name>A0ABY7EK38_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MAR_019084</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="15">
        <location>
            <begin position="1616"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="14">
        <location>
            <begin position="2152"/>
            <end position="2416"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="16">
        <location>
            <begin position="2447"/>
            <end position="2479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="877"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1956"/>
            <end position="1987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAR09126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2479" mass="279748" checksum="7224C05EBABBED35" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMW6</accession>
    <name>A0ABY7EMW6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="153" mass="17855" checksum="7B18874EB2C8C5AF" modified="2025-10-08" version="1">MFTNIITDTMQERLENVSIECLCKVGVCQPPLIVAPITVNPTKPNIPRVVRKGAYFTYLDDKSGFNNIKLSEHSYQYDCVLLMGWILFFFQNFGIWIQAKQLRLPHLKFANAVLHSPENRSGAINVFQQITSYSGKLYHMRYLDKTWLLFEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMZ9</accession>
    <name>A0ABY7EMZ9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MACF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_035262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043197">
        <property type="entry name" value="Plakin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169:SF23">
        <property type="entry name" value="SHORT STOP, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="421"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="GAR" evidence="6">
        <location>
            <begin position="468"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="551"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="589"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="608"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="635"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="652"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="680"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="693"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="721"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR10186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="755" mass="85505" checksum="9CB6E4070B6DEB0E" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPF7</accession>
    <name>A0ABY7EPF7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BOP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_026058</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="8">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR11878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="92" mass="10604" checksum="C553B82B1B43E7EC" modified="2025-10-08" version="1" fragment="single">MAHTTDNNVDKKPTMLDNDDDLADTKPTMFLDNDESKPSASKDIRNTVGNIPMEWYNNYKHIGYDVEGRRLIKPQQGDNLDDFLNKVDNPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPZ1</accession>
    <name>A0ABY7EPZ1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_026105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="8">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="9">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="420"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR11925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="451" mass="50675" checksum="92DF2C3B62D4D2FE" modified="2025-10-08" version="1">MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYVPRAILVDLEPGTMDSVRSGPFGQVFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMMTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFLTGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAMFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSGTFVGNSTCIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFDEEDEDEQHGTKDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVK8</accession>
    <name>A0ABY7EVK8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TRI45-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_027510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF229">
        <property type="entry name" value="TRANSCRIPTION INTERMEDIARY FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="45"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="138"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="288"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR13330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="678" mass="77078" checksum="37C492575666D1E1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZ44</accession>
    <name>A0ABY7EZ44_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CASP9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_005292</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1470">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF8">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="CARD" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p20" evidence="9">
        <location>
            <begin position="63"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="8">
        <location>
            <begin position="238"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR15187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="358" mass="40240" checksum="211A37EAAE323616" modified="2025-10-08" version="1" fragment="single">AQKTPNDKVRKIIDTVPKRGPRAFGIFLEVLHATDNTDLAARLSGSGMGDGHSRGVYNMKKQIRGRCFIISNKMFYATELDEKGVARSKLGTRYGTEKDVEDLKKLFQQLHFQVDVKKDLKKDEMSTALFQESSNMSLRDMECYVCVICSHGTREGIYGTDGGVITLEEVTSYFDDQVDRTSGQTGDLGQDLSTLSRQFKKSVSIKDGCQPDAGPEPPRPQVFVEPTDRTDAVMGNTEERSVPSKQDMLVACATHPDFVSFRNEQFGSWFIQAVIYVFQKFAATESILDLLTLVNRLVAIGRTSTDRGLLAPRDATQCARFESSLTKKLLFFPGVLIHQMYTIHQKLFEAQDNNWIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZE0</accession>
    <name>A0ABY7EZE0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="1">PARP</shortName>
            <ecNumber evidence="1">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.-" evidence="1"/>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd01439">
        <property type="entry name" value="TCCD_inducible_PARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF2">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR14206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="153" mass="17359" checksum="65C94EF3B99C5A75" modified="2025-10-08" version="1" fragment="single">MGVDVEERQLFHGTRNDTVEAIYRQWFDFRLSGTATGTAYGKGSYFATTAVLSDRYTVVQNGTMPMFIAKVLVGDYTKGDKSYNRPPQKDPLDMSSSLYDSCVNSVTDPQIFVVFELDQVYPEYLIKYKTLVDYPHEVPTETINYNGSIDAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZN3</accession>
    <name>A0ABY7EZN3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046289759" description="Secreted protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11450" checksum="EE0A59D36BD6BD07" modified="2025-10-08" version="1" fragment="single">MVLPRIWNLWGYCRMLVLLLVFCYIVSADDQFLCCMAGIKKVRHISICPAPCCHGYEEHSVYTAMMAQISFCRKVEEDTSQELTPAINRAFLVKFLVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0C2</accession>
    <name>A0ABY7F0C2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="450" mass="50033" checksum="5951F2F6A2003BBC" modified="2025-10-08" version="1">MTGSDVRIQMKDDYFTSVQNLHTVGDNICGQALFHISKASWKSFQGNAYWWFLNVCTTGRFQMMRYYVGNHVSAGANFLTWQIKWFVRDSGPSVYKHTSGGTTLNGHLNDVITDVRHGADVRGVLESLGYTAKMDNVQISDTGNLVVGQAVWHVSQSLAPPNIEFQGNDYWWFSNFASDGGHYMSRWRIGEHTSVGATNENRQITWYTDTCWQLAYQHDSAGNELQGSLDILRSAAERGHRVKIMIGDTSVEPEQVSVRGGHVNAMIISKVLKANSNIKEFDSTGVWDWSMVTTTGTQTTLKLRVGEATRATTATAVKWFIDTRPWRKVLAHNKAGTVTSGSKVALTDAVKLGARVRYIMRFDGSDSITVQEADNIAINGADVGATHVRSVSLEATPGSTAEFRFQNNPYWWFSIAATTGSVDMSRWTVGEHTDRGHSSQTAAIEWFVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1G6</accession>
    <name>A0ABY7F1G6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_004811</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="6">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0186">Copper</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0801">TPQ</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046722626" description="Amine oxidase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="10">
        <location>
            <begin position="55"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="9">
        <location>
            <begin position="270"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR14706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="479" mass="53805" checksum="A7B0536C9AC37145" modified="2025-10-08" version="1" fragment="single">CFVVLLLVAVFALAIALGVVASRLRDQPDSCPTSSNIALDPPDNLPPFYDLTHSEIQAVKRFLYGQKELNLVKPSVITLNSSYIFSFELLPPIKQEALDYLDNGNSQPVREARVVIFRGDSKVPVSEEYTVGPTANPTYMKDKGTFPFRYRPLTGPETVAAITLLHAEIGGKANAILLESYGGKLGDCSNNCLGFEMITPMSSSASGEPMNRKMWYWLAPTVEFWSLNSLDFVVRVDLTSSDPDQYYIDRIFHAGRMFRSVDELVQAYNANTFAKTRTKMVRKQIKNEASAAVNYNLSTPKYLTFYNDKVKTRAGSPRAYRLLMKGMSKQMVTPGTGQEPSVSWARHQLAVTRYKDSERRSSSIYACYDGENPDQVAWVTMGVHHIPHMEDQPVTPTVGLDLRFFLLPYNYFDEDPAIGSGDAIRVEPRDQNDLNAGLRVERYGRKENAQCMPQKSAFDEELENKPESLFDKPTGDFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F310</accession>
    <name>A0ABY7F310_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CCKAR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_005203</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF47">
        <property type="entry name" value="ECDYSTEROIDS_DOPAMINE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="23"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="305"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR15098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="431" mass="48507" checksum="7BCFEE5012EF409C" modified="2025-10-08" version="1">MEDPAVVTVMAMLSMFSICGTIGNSLVIYIFSHKKEKSTAGIFIMCLAGTDLFTCVFVMPFTEVVVYLNYMVSYDVACKVYMFLITCNVPFAAFIMVAIAIDRYFCICHPFLHVLNIFRAKVIVLCLLIVASTFGIITSLSYGVYSYELVVPENEALASTNETKTVLYGQNATLNTADHGMCSNCSNELWELDVGDLHVFGKNKTDMQAGFELNYTGLCAPNHILTGPKFLNIYQRAYAGTYLLSFIVVFVLYGLIYRSIHKYRAKRSRRKRSSLYPSGVSHVTSLLPPCIESMKVETQLTAVTHVNPHSGRRSDPNLKHGDDNVDVQTPTEMQPRRPKPHNVTRAISIKEKTLLANIRTAVMLFVVTVVFLVAFLPAWLMGLQAIEFNAVIFYMYFVYHTANPFIYAFMNKSFRDDLGKVLKCQSIPLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F443</accession>
    <name>A0ABY7F443_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Beta-N-acetylhexosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-beta-glucosaminidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_005664</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd02847">
        <property type="entry name" value="E_set_Chitobiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004866">
        <property type="entry name" value="CHB/HEX_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004867">
        <property type="entry name" value="CHB_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF57">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03173">
        <property type="entry name" value="CHB_HEX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03174">
        <property type="entry name" value="CHB_HEX_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SMART" id="SM01081">
        <property type="entry name" value="CHB_HEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="Carbohydrate-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046094091" description="beta-N-acetylhexosaminidase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="domain" description="Chitobiase/beta-hexosaminidases N-terminal" evidence="9">
        <location>
            <begin position="31"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR15559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1628" mass="186165" checksum="684003A5456E9CDB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4Q6</accession>
    <name>A0ABY7F4Q6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR17173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="148" mass="16974" checksum="6C8920131577338D" modified="2025-10-08" version="1">MFGLPPESEIDVCQIEYAEWSKQAMSSSFETAKLHLTDATKRQKTYYDQKAKLSAFEIGSFVWRSELFYQVQRSPTKPVISVNVDHLEQYLGNNAPESWNNGNDGSITIELPEVEDLPFLENTVLEYPESYDNYPTTPLPFVPNDEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F557</accession>
    <name>A0ABY7F557_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_030776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR16182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="205" mass="22634" checksum="177210553143D209" modified="2025-10-08" version="1">MGCHTDVSPVTVTITDVPPTTTAATTTTVLPANFNNISSFLDDTGNLAWLIPAVILGALMLGLLGYMCFRCCANPALCASLCRGRCFGGGKGFRRARAAPRTVVRRAAPPTRTVVRRVEPVKMVRRVESVQMVRRPVTPVKVVKQPLPETPKKESSSMFDCFKRKPKPPEVKTADGNRSWHLWNHTDFKQQDSYLLSTNSMSNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5N3</accession>
    <name>A0ABY7F5N3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPNA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052079">
        <property type="entry name" value="E3_ligase/Copine_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45751">
        <property type="entry name" value="COPINE FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45751:SF11">
        <property type="entry name" value="COPINE FAMILY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copine C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="181" mass="19835" checksum="A3A76DB2D674FB51" modified="2025-10-08" version="1" fragment="single">VICVLGETLEPLDDDGIIPAYGFGDKGTPDRKLFPLKPENDCDGFMEVMDVYNHVTPGLKLGGPTNLAPLIDEAVHIYHILVIATTGQLACQAETVASIVTASNFPLSIVVVGVGDGPWDAMNDFDDLLPERIFDNFQFVNFHKVKQCARNPQASVALAALMEIPDQYMYIKDLKLVEKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5Z2</accession>
    <name>A0ABY7F5Z2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTP27-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="81" mass="9696" checksum="98E42B9AAB387295" modified="2025-10-08" version="1">MYVDAKAHEAFRTEFESPKCEQYWPKPGTTMKYGDIKVESCSEDEYAEFTRRVFTVTMHLQHTLETRPKMKQKQWNEINST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F756</accession>
    <name>A0ABY7F756_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR17204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="125" mass="14609" checksum="7CF95514A1AE963B" modified="2025-10-08" version="1" fragment="single">MSFAHALFMQMEIVSHRVCTGLWSEKGIRVRIIAELVRNEAKYLDNTYLSEGTENECKNSDFPKQYAQYSEEYILGTKLNYKTIHSLYRKEVLSITEKNTFMGIWQFHALATILNTPIYSVYPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8D9</accession>
    <name>A0ABY7F8D9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPNA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052079">
        <property type="entry name" value="E3_ligase/Copine_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45751">
        <property type="entry name" value="COPINE FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45751:SF11">
        <property type="entry name" value="COPINE FAMILY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copine C-terminal" evidence="1">
        <location>
            <begin position="57"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="252" mass="28234" checksum="2DBE2677740D6958" modified="2025-10-08" version="1" fragment="single">MAGRTAGKKVGRRNALLDAMNSMREECAEDAEEVKFQRIADKFHSLKDGKKTYSGLSLHDVQPSRSNPYQEVETLEPFDDDGIIPAYGFGDRTVKDKGVFPLKKNGDCDGFMEVLKVYTEVTPTIKLKGPTSFAPIIRKAVDIVKEKRKYHILVIVADGQVTNEKETIEAIVQASEFPLSIVVIGVGDGPWDMMKDFDDNLPARKFDNFQFVGFTKAKQGVRNPDVAVALAALMEIPDQYMYIKKLHLMENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9S3</accession>
    <name>A0ABY7F9S3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="422" mass="47701" checksum="8D3AE00B1054F547" modified="2025-10-08" version="1">MADVGLNVVGKDTDKTERSSQKGKAPAKRNRDEGHTKKSTPVSENMQTKLSASEDNMLSALNSIQSTMKQHSEVLNSFAKRLDVIENYDDEYEQEDYYYEAAETEVSHEPKRRAEPSDLNNYRFKDMAKRFKAAEKCDKEVNSVLAANINDLFLNGIEEERYSELVKDENNARPANCEGLTVVRMNQLIWDAVSPAARTADKKLQNIESSIVKGATLLTKVVDTMAKLENSASDSDLGSLIENCNDALALLGHANKQVNLTRKYFLRPELKQEYSHICSQSRPFTKLLFGDDVSTSAKEIKDCSKISYNIGPIRRGVMRGRFRGNYSARFRGRGRCPSEPSTPGILDDIQTIKQVRPCFKAGRIANFIKEWRKLTSDPFILDIVQNCHIDLDTCIDIKSNCVQYKFDPLEEGIIDKEIEKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FA82</accession>
    <name>A0ABY7FA82_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">YHDH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_032298</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42948">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42948:SF1">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR17704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="527" mass="59372" checksum="E3D405DD097E87F7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FB29</accession>
    <name>A0ABY7FB29_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VPS39-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_001223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="4">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR19385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="598" mass="68869" checksum="87CB79643284600A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FB40</accession>
    <name>A0ABY7FB40_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_000019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR18181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="306" mass="34950" checksum="D02BCDA90D7D4B65" modified="2025-10-08" version="1" fragment="single">MESYMELTQSKDNQNWYKTLIGLHITKEGLVDFVIDVIKCFHRRTFDDINRINGRPSGTARKIANNTRHSSSLQIDDITLQENLDTMKDLLWDSKRLATDPKATSAVTKLTQLENDQLLMTEADIRTVVRITTEGLSDKIEELRNDLHEFNSEMHCTSSISPMIQGKRSKIVDFYVAPSIETISTNRRYSCKGDHISGKGSVSTFREIFNSAEGKSRYVYVSAKAGAGKTAFCQYVAAIWCALQRNDKEEIQTFKKNNKTGHFEDICVLKEYDFLFFVSLREIRDQLCDVDDMIFQQIVTNLSGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBH1</accession>
    <name>A0ABY7FBH1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MRNIP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_031240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032739">
        <property type="entry name" value="MRNIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049472">
        <property type="entry name" value="MRNIP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15863">
        <property type="entry name" value="MRN COMPLEX-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15863:SF2">
        <property type="entry name" value="MRN COMPLEX-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15749">
        <property type="entry name" value="MRNIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MRN complex-interacting protein N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR16646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="139" mass="15481" checksum="312F533A4C23A0B2" modified="2025-10-08" version="1">MPQEFQVVQCYSCSTFQVHQVKKALKWACKMCGEKQSIKKVFGRGTGAECRQHVQKLNTRRGDLDTIKQTVTLASDVDLLDDNTAETATEMQYVPTEIGKWSQFVDAQQDGDNNSSSDDDDEGLTTSSLANARGRKRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBK0</accession>
    <name>A0ABY7FBK0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR18053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="114" mass="12881" checksum="D00383D9D939C228" modified="2025-10-08" version="1" fragment="single">MANGLNCTLSSDQEVSGKQLRALVRCILKEPREETEDVYNFTKIMAGRIRRQRHVDGTQRRFGHATPSGHCHLRYACSDRDHRKLDRTTASEQTEGTYRLHTPVGKAASNAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBP8</accession>
    <name>A0ABY7FBP8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_001368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd08161">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="838" mass="95984" checksum="86560AF3D7E5D441" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDK9</accession>
    <name>A0ABY7FDK9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HPHL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_002101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF504">
        <property type="entry name" value="PLASTOCYANIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045740415" evidence="4">
        <location>
            <begin position="20"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="90"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="836"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR20263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1019" mass="114409" checksum="4956EE8957096424" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDM1</accession>
    <name>A0ABY7FDM1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MARC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_000960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Molybdenum cofactor sulfurase middle" evidence="2">
        <location>
            <begin position="40"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="309" mass="34306" checksum="A0E9D819B46D868B" modified="2025-10-08" version="1">MTIMSMPLNNETLVALLVGSVVKFLGLGIISSRKRKELVGHVSRLYVFPLKSARELPGETHEVELTEYGIVYRGAGDRHWLVTRNGDMMTMKQSARLTLINTSLEADFLCLDAQGMDTLRLSLQPEVDPKRVSNVTVKETPLPALDLGDKAAAWVSAVLRMDGLRLHHAAPGLQRRLSCKVQKAWPTQIADTDEVAFQDFGHCMIMTESSLDELNDRLPEQMSAIPFRPNNMSGNETDEEVTFRTVTTRDEAADEVGATNKIEGALRELSVNAKSDPRRRVCIHMQQRHEGNILTGTRASESRTAVGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDN4</accession>
    <name>A0ABY7FDN4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase Q</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Plasma glutamate carboxypeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">MAR_002028</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">MELC-2E11</strain>
            <tissue evidence="24">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="20">Homodimer. The monomeric form is inactive while the homodimer is active.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039866">
        <property type="entry name" value="CPQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12053:SF3">
        <property type="entry name" value="CARBOXYPEPTIDASE Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12053">
        <property type="entry name" value="PROTEASE FAMILY M28 PLASMA GLUTAMATE CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 22" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="17" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047037511" description="Carboxypeptidase Q" evidence="22">
        <location>
            <begin position="16"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="23">
        <location>
            <begin position="227"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00025833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="WAR20190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="375" mass="41132" checksum="7B3587C0B5CFAF23" modified="2025-10-08" version="1">MISVVLLVQSSLVAGIDINRVRKQVASYKDVANRIIDLSLNGAAQNQSYNRLATFTDKFGYRLAGSQNLEDAIDYMLEALKMDQLENVHGENAVPRVHKLPMLGLGYSVGTGPQGIKAEVIVVKSFDELEKRATEVPGKIVVYNQDYHGYGISVRYRASGAAKAAKHGAVASLIRSVTPLSVDSPHTGMQVRWVRGEQIEVFLNMSAQNLPNKISRNTVAEIKGSLYPEQGAMDDGGGAFISWQALSLVRQLGLRPKRTLRLVLWTAEEFGGVGSQSYFNEHKLLKQINASNLDTGGEGTDISPWMKAGVPGASLANMNQQYFYWHHTNGDTMTVQDPVAMNLCSAVWAVTAYVVADLDEVLPRDNHIHVRVALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDW8</accession>
    <name>A0ABY7FDW8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZN182-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_032050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR17456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="225" mass="26292" checksum="DBD734EAB5775014" modified="2025-10-08" version="1">MKSPLAESLMQQASESLVLSSPKKEKLGGLYVMCTLCDKPMQSPSHLVRHMRIHTGEKPFKCEYCDYSSSRKDHLRRHYLNTSKCMKLMREVPPEKPFECEICGYKSSRKDYIRIHQNTKKCKKMRETFMNFLSLDWLLEGSPEDLSQNQPVNAKKSLTEKVGERYYVCEVCNKLQPSPSHLQRHMRTHTGEKPYSCDMCASRFTRKDNLEYHKLKNCGKRASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FED7</accession>
    <name>A0ABY7FED7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_002283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR20445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="63" mass="6910" checksum="0B17124DE13AD972" modified="2025-10-08" version="1">MKNDNFDNFLVVEFSSESDMMRAIDKMDNTDINGKKIKLVEEGRGGRGGGSGGGSRRRIKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FER6</accession>
    <name>A0ABY7FER6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MATN2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_001061</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052080">
        <property type="entry name" value="vWF_C/EGF_Fibrillin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333:SF4">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333">
        <property type="entry name" value="VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Galectin" evidence="12">
        <location>
            <begin position="41"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="11">
        <location>
            <begin position="185"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="358"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="626"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="708"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="749"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="753"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="774"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR19223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1004" mass="110558" checksum="D68165EE1664799F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFB1</accession>
    <name>A0ABY7FFB1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_014819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042342">
        <property type="entry name" value="TTC22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16253">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16253:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR20845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="573" mass="64380" checksum="A78547663DE7F2B4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FG71</accession>
    <name>A0ABY7FG71_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ARMD3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_015144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039868">
        <property type="entry name" value="ARMD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013636">
        <property type="entry name" value="ARMH3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608:SF3">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08427">
        <property type="entry name" value="ARMH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01158">
        <property type="entry name" value="DUF1741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Armadillo-like helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR21170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="562" mass="63783" checksum="1901B517F61CF324" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGE9</accession>
    <name>A0ABY7FGE9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="495" mass="53426" checksum="D231C02B941CEA06" modified="2025-10-08" version="1" fragment="single">MSESTPGSQKKGVAREADHSSQGNSQQMQFGILYPSTSLAGDRPSNKAPGTIEENKNIRTDSDGHKTMERSMLYETHTQSKFTNLSSYNDKSIQPKLKYTGKGPPKVLHGNNNQQSAASVRQSGRSKHAILQGDASSYGSAFDTSAGSDKLKSNGEYEISKQGRVWCIRDLKTNKLTTLKTIKADEVFFESKELVSVDGVFHQLIVHNGKKPKLEIAERSSSSSEDERKPNACDFSYGSDDYSESRTTPNSLPESEEPSSQAEETQSSDVNQSDERVSKQQNNTRSKYDDVSARPKRSLYEGNDRGQASPSYNPGSTGGSHDGSTEQPRKPRVTGTGQETEAEETQGSAVNRSNEKAGKQQNSSRSNPDDASARQKGSSDDGGQPSPRYNSGSTGDSHDRSTEKPGKPPVNGTGQETEAEETQGSGVNQSDERASEKQNNSHSNPDYASKRKKQGPGDGGDGGQPSPRYYSWLTGGSHDGSTEHPGKPPITGTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FH90</accession>
    <name>A0ABY7FH90_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_001916</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd22932">
        <property type="entry name" value="HFD_TAF6L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF22">
        <property type="entry name" value="TAF6-LIKE RNA POLYMERASE II P300_CBP-ASSOCIATED FACTOR-ASSOCIATED FACTOR 65 KDA SUBUNIT 6L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="9">
        <location>
            <begin position="15"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="422"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR20078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="476" mass="53385" checksum="094E8D9C6CFB00FC" modified="2025-10-08" version="1">MAEEKRIVTDERRYAIMSRESIKLMADAAGHEETSDSVAGILGEDVSYRLREITQKSAQFMRHARRKRMNTDDFNKACGFSDIQPVLGHGSQEAVHSFQAVKVEQGEPIHFALDPTLNLATEASSTFIPKHSGETTIKAHWLVVEGVQKSTQNPQGTPGNKVEPGGPLMKYFDKITQAVLGNDEEMMKTALSDLRTNGNISPLLPHFVSFISNGVKTLGDDVCKLTRLLSMVQSLVYNSSLFLEAQPFLAVMSQSVQYCLLDPLVSSGQSCPTDDHWVLRDYAARVLAHIVGIWGNSVNHLERYTEKTLREALHDLSRPFACHYGAVMGLMYLGTEFREENITDATNNGEAKKVFKTISDYDTKFSKRPSFNGFLSAFHKSPVSFYFEMFEYFGDALTLRLPEIAELKSHVFKPKERDLVTSISDPTADKSGEELLKIKERDRNEENPGRKRKHNSPSPDVDFSQFLGGDSWTVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPQ2</accession>
    <name>A0ABY7FPQ2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="128" mass="13948" checksum="06EEB200DB2CAC46" modified="2025-10-08" version="1">MVSKISVPLLQMVGENSVLLLPMVGEISVLLLPLVGENSVTLLQMVGGNQCTVIANGLFDVPYPFVGPGAQNLYKGTVVCARTLRVNCYLDGGFKFPGVIIDGRLQQSQHEVLEPARDFRHQLRTQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPV3</accession>
    <name>A0ABY7FPV3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TRI56-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_036402</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="133"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="198"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="318"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR22733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="743" mass="83871" checksum="3652835F2459FA87" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQN5</accession>
    <name>A0ABY7FQN5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_036890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045622739" evidence="2">
        <location>
            <begin position="23"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR23221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="120" mass="13778" checksum="375ED2A6BAE4A1CD" modified="2025-10-08" version="1">MGLLTVLLIGVAIRVLRTRTQSSKLDKRLANLHRKERPMAEKKVHKPEGTAEEPLPDYSETDSTYHDFNEERTTGVFNSPPRGRVTLFNMKACQSDKYFRQTFARETMRQKVKGPTASHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQQ3</accession>
    <name>A0ABY7FQQ3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_038222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="139" mass="15806" checksum="5A6693680ABCCBC9" modified="2025-10-08" version="1">MKEEASKVKTLSKSFSGRISIDEMSIQEDFCMSKENGGYRKIGFIDNDEYCQKINAGKWYGQSILPYILSSARNSIVPSRVNSDELENVFYQQRGICNGKNTNPIFYQYLKNMNSVLLGKQTVSKKCKRSQNLMSTACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FR84</accession>
    <name>A0ABY7FR84_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CPMD8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_038209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Alpha-macroglobulin-like TED" evidence="3">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR24540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="118" mass="13179" checksum="0F71EDE284EF5A3A" modified="2025-10-08" version="1" fragment="single">MLYWQETAPVPSKYHYGPSTTAVSIEMTAYALLSMSVSGDRVDGARVNKWLIGQRSPYGGFISTQDTMIGLEALAAFGALMKSPPADMTIWISYMDDRHHKRKFRITSENAMVLQTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FU42</accession>
    <name>A0ABY7FU42_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_038048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="3">
        <location>
            <begin position="60"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="2">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR24379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="367" mass="41754" checksum="F64881AD67EC1227" modified="2025-10-08" version="1">MAITRSISDILCSDLVSYRMEWLPILDRIIGENKVIVSLKVDRENLFQQVIDFYKKCNPKQHVQVIVRFVNEQALDGAGVRRELYYTFFEECLGERRHMFVGEGRHKFPSNEMNFVNKGYFEALGRAIVASVLNGDCGFPYLSPIVYKYLVGEDYTDLLTLDAVPDPSIKALVKDLRAAKSADDLLAVIDSKEGALKNIESLIQQLIKWDIVDKRKSSMDNLKLGLEHMGFLQKTKRNPSLLPLLVFSEKHRITAYYLTTKLSPKIQDLKCDGDHKKESAKSFMLDWLHNLTDEDAESFYQFVTGSADPTVADEEIVLEFNTFEKGQKFPKASTCSFIFRIPLGNANSSEFQKSIKVALDNAKCGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUY9</accession>
    <name>A0ABY7FUY9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="67" mass="7525" checksum="C9EC107DF5F7B9CB" modified="2025-10-08" version="1">MESGKRTQTANRTVQVLILTDLETFRVRKLESQTYKLEGHAATKHAAGYTRHRNGAVTGRTPDQEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWY7</accession>
    <name>A0ABY7FWY7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_037350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF8">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="10">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="362"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="273"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR23681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="599" mass="67958" checksum="F9E4F81852510FB9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FX94</accession>
    <name>A0ABY7FX94_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CC020-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029281">
        <property type="entry name" value="FAM194_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23093:SF16">
        <property type="entry name" value="FAM194 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23093">
        <property type="entry name" value="SIMILAR TO CHROMOSOME 3 OPEN READING FRAME 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14977">
        <property type="entry name" value="FAM194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM194 C-terminal" evidence="2">
        <location>
            <begin position="249"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="814" mass="90784" checksum="13D137BCA21EA619" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FY79</accession>
    <name>A0ABY7FY79_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="237" mass="26579" checksum="A8056E6B7E36052B" modified="2025-10-08" version="1">MSSDTSHFFLLVVCADSYHQQCMDFRNQFQHFWTRNQTETSRSHKRTFGSLGSSAMWTTWSKWSVSSGKCHEVGVRTKERKCQRLNKVPSTACIGNSAESESCNSDCEKLRNWSLDPDGSCPLSGEQYLDIVVKVGLLSQTLRWYNPEAEDGHLMAVTQSGKNGDNVPYHVILGIGYVTDNATVPGLQQRGRTAEVLGALRTRNSVLCIIARVSLFCIIIIFNFHLVISNYFGGMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYB1</accession>
    <name>A0ABY7FYB1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AN13C-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_037770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055285">
        <property type="entry name" value="ANKRD13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447:SF25">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11904">
        <property type="entry name" value="ANKRD13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ankyrin repeat" evidence="8">
        <location>
            <begin position="244"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR24101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="442" mass="50375" checksum="E96737AB5FC99D56" modified="2025-10-08" version="1" fragment="single">MSNIQADVSPGDDFPLHHAVFSGDTKLVSQLIRVHDLAQKDVHECIMLLLSRGAPVKVKNNTGWTPLAEALSYGDRKISLRRYRRLLSRAQVGLPQLGAFSFQNSAIRLMQNTQKRIMYKASPHNALTVMDNKLKVYQRIRYEENIGEYAAEFFNINGLVLESKKRREHLSQEDIQKNKAMVENLTKGSWDNKEFSRRSSLPPPESPTVLWEEYISAPIGNVPCIGRPHLSKESQKNFKATIAMKLRDFMENKLPPGFPVKLELPVFPTVTAKVTFCFFEWRDDLSDELFSIPSTALYQCDESLPAKQREVDGDHKTGPSGTRCIENEQISSVDPEHGTYTRSSASKNDNQDILGHEEDADLLKLKHKSIYSKPDSHDCLRLSEYFSECQSESKSKAMGYSEVCKAGTIQERLSSLYNYGSGEENEKELLVDEQQRERYRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZ05</accession>
    <name>A0ABY7FZ05_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22351" checksum="C9D00769D378A261" modified="2025-10-08" version="1">MEIKYDLIRRYNSSANGKRKVDETWGEVADAVNAVGNGPRTVVQTKKAKTDYTAEQASLLKTGGGPALPEMSTGSYAIIDLLKDSASFSGTTGADLCETVYIIYFNICHSVFFPQLKEKTLKLLLSAKTWENQSHKQQKPMPEPVPVKVSATRVTPQNEKAKTLKELQMAYYMEATENQKAQKECFQKLSTLADVLTLKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZ22</accession>
    <name>A0ABY7FZ22_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABCA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_038025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="73" mass="8928" checksum="7F09504EF66CE60C" modified="2025-10-08" version="1">MVQKHIQWEKSLFSSLTKDMLKFDALFDELTTREHIQLYSRLHLRKTRWVGHIVEWALKKLNLTYYQYKKSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0N5</accession>
    <name>A0ABY7G0N5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMPC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_013719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF15">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046880446" evidence="1">
        <location>
            <begin position="20"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="32"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR28015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="121" mass="13477" checksum="DBFD27920D2B8F5F" modified="2025-10-08" version="1" fragment="single">MLYVLRYFVAAIVFTSARGAVFDVETEQDVVNVIQATLECRHVSGMTVGIFKENETWTRGFGMADLKSGRPVDGDTLFNIGSVTKSFTMALLAILLKENKLHWTAKISDILGSEYGFIDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0X5</accession>
    <name>A0ABY7G0X5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_012588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR26884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="184" mass="20477" checksum="B8F661E261BC457E" modified="2025-10-08" version="1" fragment="single">TEINQYLDKRENELLPDIDQKKRTSKTLLDELKSKCTNMKSSIEKLKSELQAQDDNSNQLLIVGKRAIKELAGLQAALEDGPRNLEDNSFRKNNRTVGRGRINVGVRTATPTTTNEAGTTATGDDATTPKTDESCITKRRINCCCRAARTTTTEGATTTATRDYAATTKTHARVITKRFVYNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1D2</accession>
    <name>A0ABY7G1D2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NRP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_012515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF5">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR26811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="202" mass="22061" checksum="ECFBA9CF05B04443" modified="2025-10-08" version="1">MTASSYLDPNTPSSGRLITGIGWKPSVRGEPFCGSEWLQVDFGSDTYVTGFKLQSSNDDAQDVVSSFTVKYSLNGYAWYDITEMDGVTPKKERFSARYIRVVSTDVRCTVGLRLEVLGVKSTTSAYDCSSVTSNTSPLPEQSYVVNTDTGTILVCGASEVEYLTSISFPYADYRGETDNEMYAVYGTDGDGFKLTGTLEGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1V5</accession>
    <name>A0ABY7G1V5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HARB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_012919</name>
        <name evidence="5" type="ORF">MAR_013198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="21"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR27215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR27494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="86" mass="9932" checksum="0503916860305456" modified="2025-10-08" version="1" fragment="single">IFTHVNWRFAFSGFPNVIGLVDGNHIRINAPYQYKEDYVNRNGYHSINVQMVCDAGFRIQNVVVNWPGSVYDAPIFRQSSLCHDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3P2</accession>
    <name>A0ABY7G3P2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_013646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF6">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER M-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046801248" evidence="2">
        <location>
            <begin position="31"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="116"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR27942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="214" mass="23893" checksum="9622EED78A8E6E3E" modified="2025-10-08" version="1">MQSSWPNVVMKIILIMVCLSLLELLASVRGDISVQDYSKYPGNSAITGTSLGQTSARSAVRCSTLCSRHEEEKGERCHAARYHGETRACELMSRSGEGAEEWLVDGQWNIYVIQMGATLAVITDHGENGFLKGLLESVYGSHYYWLGANDVLQEGVFKWETGEDWGFTAWAVTPWVQPLGYAGYNCLGIWVIGYDGWVDYLCEYGAWYVCEKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5A4</accession>
    <name>A0ABY7G5A4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_002670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001">
        <property type="entry name" value="OS01G0253100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001:SF118">
        <property type="entry name" value="OS01G0253100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR29102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="250" mass="28936" checksum="29DFFE9A6AD83AF7" modified="2025-10-08" version="1" fragment="single">MDEQLAFNGKAGKLDERVFSKLKLLCRPVKARQNTAKQGNETTFVSQDDVPFYNTRLVLRTVEKPWTGDLSKEEIENNLEQIILHYAIVPQVAYYINKQTVSLVSPYFGGGTLDEVIQKERDKKATIETEIPSDRKPEIALERPQTLEWKDKLRILYQICRAIEYLHQPPKCERKPVSHGNICMQNVLLDEQKNARLLFLAPKSVEGRVREIQFQEDQNKDVQTFKEMAQEALQQSRKKAASDILAHIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7V7</accession>
    <name>A0ABY7G7V7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polymerase nucleotidyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25649" checksum="8289D32692340A71" modified="2025-10-08" version="1">MEGNIKHSTLKNMAAPEPSRESSLKTSQPDNEYTTENLPPAQPETRPKQGQPLQETLSSDPGNDSRVVHQSGLPEDIYAVSVHVCEVMDKIGYSDAMVRYRQESYRNNDFSELNMIVTGSKGEGLSTPYESDIDFLFLMKTILCRIPGYASLQLPDINTVCIMDGEHCHPGHFWLELDHLGTVEETNIKATLFVHTNGKAYLSSQKLKEIQNQTKHTTSVSGPAVTYTCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8T8</accession>
    <name>A0ABY7G8T8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IFI44-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_003340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFI44 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241:SF32">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="7"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR29772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="479" mass="52385" checksum="C69FC66A7CA5D171" modified="2025-10-08" version="1">MIMQLAFRMTGKLTKYQMDQLEAFIGSGPKVFRLLYSITRDGCAATVFHRKCDNQGPTVTVLYNPHGSVFGGYAGVSWQSSVGFHTEDNTAFIFQLMYSGKRAVNIFRPKDASKAIYCNSNDSSNFGYPDFKAFSNTVPLNNDGTFSLNGSISLGHFYHNNNVSNKDINNGSMVVTEMEITLENQRTRTEYGEKTPALTDEYISKLKEELASITPPKGSGITDFQLLLVGPVGAGKSSFINTAMSPFADRIMHKAAVGTSSQSVTRKYITYPVRKSGGSCLNLRLCDTPGIGDHSGLDALNINFLLDGHVPSSFEFSCSRHISAKTPGFVHRPSLAEEAHCVAIVLDSSTINDLPAVTMTLLNDLKNLALEKGIPLAIIMTKIDKLHEEIAENLADVFKRPEVKTAVDQVSEAFGIPPNHVFPVKNYHSEMETEIAVHGLALLALRKMLFIASDALEERTSANEERQGSTADVTESDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9V6</accession>
    <name>A0ABY7G9V6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EMAL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_033745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF58">
        <property type="entry name" value="HELP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR31203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="198" mass="21903" checksum="05F005931B88D561" modified="2025-10-08" version="1" fragment="single">LNTDLVCDIGFNPKYPDSLVTVGKEHTCWWKVYPDSATIQNSASPEYDQFLRAKFTICLDFNEGGDLVTVMYYKSYILSGGRDGIIHCWVCNKNMDSAAFVKLPETEGGVRMLCVGQKELMIGTTMNSLLVVPNIDNEPPLRGSFIEHTPLTQSHYDDVRGITRVTNSSTDIITAGLDGLICGYSTSGKISKSKVQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D7V0</accession>
    <name>A0ABY7D7V0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTBD6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_006222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="44"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ93751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="444" mass="50328" checksum="7B8A79D8696797D5" modified="2025-10-08" version="1">MEVCEEERKQMMEITMHNKSEDPWQYSDDFAETNLQLLETQILSDIAFSFEEGKEVVRAHKNMLSSRSPVFYTMFCGPLQESSAVIEIPDVDTIIFKQFLRFLYTKSCDVNADSVMYLIYLSKKYDVPSLQNTCREFLKKGFNVENVCTILGQALHFQEVDLQRDCLNFISKKTAKVLKSVSFLSLPPSTVELILQEESLKCYEIDVYFALKAWAVKACKQKGNDHANTDMIREEIGCLLRLVRFPTLSAKDFATHVTDDGILTQAEKLDIYRDIILGESVSGYPTKRRQRPTFRVKRFKSVNAEPWLHGNKIDGISFTVSRPCRLIGAILYRPIHEGMVGGKISVYEDGVLKGDIQETVYFAPEKKTSNVLIPEVQLDPVKTYGICQTFTGKGTYSGKEPHLSHVVNDVKIQFGDMFCGKGMSSISTGQICGIIIDVELNVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D846</accession>
    <name>A0ABY7D846_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ93847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="54" mass="6232" checksum="314EDF2175DD1F1D" modified="2025-10-08" version="1">MKAWKQDEYFKLAFHQGKNPPDLGDRKVLLCMSTSTQIPWNNIITSVSKTHLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBV4</accession>
    <name>A0ABY7DBV4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ95152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="192" mass="21655" checksum="268D03C30FD53350" modified="2025-10-08" version="1">MEDRKHTDVEWKKETTLTLSGRQKPTVTLNGIQKPTVTLNGRQKPKVKFNGRQKPKVTLNGRQKPTVTLNGRQKPTVTLTGRQKPTVTFNGRQKPTLTLIGRQKPTLTLNGRQKPKVKFNGRQKPKVTLNERQKPTVTLNGRQKPTVTLTGRQKPTVTQKPTVTFNGRQKPTLTLIGRQKPTLTFNGSQKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DC01</accession>
    <name>A0ABY7DC01_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ95191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="334" mass="39262" checksum="521036EB6FE26781" modified="2025-10-08" version="1">MLSGRVEYKLPAIKVTTKLTSGNIVANRFAISKQNNQKKPLQWIEIFRRLMCDITESSDENLQGPNNADHESEREHHETLLRRNEELKQKINNIRAERAEQEPLVAQDELNCRVLKLKEQEGHLALKIVQSPAKVMAEQEGLKQRVQEARDLLQRKQLRLTEIERQRKDIKQTVSNLEKGLALLELIQKSVDKESEVAADVSVLIEQVQEVTEQIHETECQKERVQELLRGRQERLSKLAIMHQNKVHILQQQIMADTEEKDNFEKKVANDSEKKSHLLQYRKRMEEDVHRYQKNIEQKVEALKNKYGQLLEKTDEYNTCIADEWNKVRQLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCS4</accession>
    <name>A0ABY7DCS4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PCNT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_006986</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028745">
        <property type="entry name" value="AKAP9/Pericentrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005539">
        <property type="entry name" value="ELK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019528">
        <property type="entry name" value="PACT_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44981">
        <property type="entry name" value="PERICENTRIN-LIKE PROTEIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44981:SF2">
        <property type="entry name" value="PERICENTRIN-LIKE PROTEIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10495">
        <property type="entry name" value="PACT_coil_coil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01188">
        <property type="entry name" value="ELK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELK" evidence="8">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="8">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="8">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="8">
        <location>
            <begin position="855"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="8">
        <location>
            <begin position="1024"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="8">
        <location>
            <begin position="3283"/>
            <end position="3304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="590"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="684"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="890"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1131"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1224"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1373"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1778"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1864"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1918"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2210"/>
            <end position="2245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2403"/>
            <end position="2431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2473"/>
            <end position="2501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3093"/>
            <end position="3307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3864"/>
            <end position="3900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3950"/>
            <end position="3981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="4240"/>
            <end position="4328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="73"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="246"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="406"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="728"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1030"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1302"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1499"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1747"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="2250"/>
            <end position="2298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="2519"/>
            <end position="2671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="2721"/>
            <end position="2766"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="2796"/>
            <end position="2858"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="2882"/>
            <end position="2923"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="2956"/>
            <end position="3044"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="3334"/>
            <end position="3369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="3529"/>
            <end position="3600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="3720"/>
            <end position="3809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="624"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="899"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="949"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="990"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1241"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1809"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1874"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2415"/>
            <end position="2431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2488"/>
            <end position="2500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="3104"/>
            <end position="3119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="3138"/>
            <end position="3148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="3176"/>
            <end position="3187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="3261"/>
            <end position="3305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="4312"/>
            <end position="4328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ94515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="4328" mass="494588" checksum="5DD86BD1502A9AF9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCY1</accession>
    <name>A0ABY7DCY1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_006414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045936835" description="Kazal-like domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="3">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ93943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="254" mass="27643" checksum="A023798255F7B60D" modified="2025-10-08" version="1" fragment="single">MKNIIFVILCLWAYHSCAEECVDFNHEACQLMLHQNATLCHDRHYALRYCQKSCGICHLECYNCDTSIITESQCTETSLCRIGEYCMTAKLASTTDGHSHYYKLGCATKKTCDGSGLFVLGRRKTTTMVFKIPTHPATATSETTFSTTHTEPLSATSSQTTPTTITSSPTTTTTPTTSKATTISTTTIKVTTPPTTTTSTATTTTYIQTAATTTSSPATLSPELMQFCQIRDSFSCPTEQSNPQCGSDGVLYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DER4</accession>
    <name>A0ABY7DER4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ERN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_028444</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd13982">
        <property type="entry name" value="STKc_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="287"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="7">
        <location>
            <begin position="496"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ95754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="657" mass="75252" checksum="42393BD5EE830CB3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DH88</accession>
    <name>A0ABY7DH88_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_029739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ97049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="109" mass="12269" checksum="42D9F799B0D9DA6B" modified="2025-10-08" version="1" fragment="single">MNLFYIVREVLTDKNIVRSLLLKHTSSIYIQIKKGFGNDQKINLLKAVQCGVVIKGDRHEKLKIGKSLKSNLIQSEIQAALPARRTPTETVTSSESLPVKTRYAFVKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHC3</accession>
    <name>A0ABY7DHC3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_028544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="421"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ95854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="642" mass="74439" checksum="2CF07339687A1C62" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DII3</accession>
    <name>A0ABY7DII3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">B3GNL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22916">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22916:SF3">
        <property type="entry name" value="UDP-GLCNAC:BETAGAL BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="320" mass="36424" checksum="A12865B32D474F7F" modified="2025-10-08" version="1">MSVDVSVILPVHNGEEWLEDCLQSIEAQTFTGTLQLSIYLDSCQDGSESIIVKWKDRLGKKSIEVMIGSHKDDVGYAKNKAVSQSCGKYLCFLDCIIGSRFHREPEGSTARFTDWANTINQQQLFTQAYTSHGPTVIMPTWFCSRAVFDIGGGFCEGGKGVPEDLLFFYKHLELGGGLYRVERDLLMYRYHPGAATFSISEDTIWKHRVTFLQQQVLSKWKEFTIWNAGKQGRKLYRSLSPENQAKVIAFCDVDENKIKKGFYTYEDSKMKPKPKIPVMHFKDARPPFVICVKMGLTEGVFEENLASLNITEGVDFFHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKC8</accession>
    <name>A0ABY7DKC8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HSP97-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_022510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="474"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="735"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="519"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="750"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="772"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ98137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="825" mass="92795" checksum="591DE479EAEA4BED" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DL41</accession>
    <name>A0ABY7DL41_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_022804</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ98431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="209" mass="22821" checksum="A08AE483246AA3C5" modified="2025-10-08" version="1">MIIEHDLYCEWLVDSGVAGQRLLLYSDDVDVNCPGDSFTIYNGSYVCENQLIHTECPERTSADSTPSSNLTSSGDSFTIILSSDTSFERHGFIIKYYEHFVNYTTTTFSTTSLTSSVAMTTKGNTALLSEQQTTTSQNLQISIPIMVSCAIAGAATVLGVIALCWMVKHIKAKKRAKKGLITVRAIAPLPPRRTTALHQRPSSSVLAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMU7</accession>
    <name>A0ABY7DMU7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_030365</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF314">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAQ97675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="483" mass="55456" checksum="726C35C3E65D417C" modified="2025-10-08" version="1">MCRCACGTGFRNYAPRVLMSRITLIQPLTSTGNMTSVLISIRQNLLSDMMRNSSMKKITRVAILLMAMWTTSLTFFVLRDTTGYLTSMRDGGKRRNITTAAVLVKDDDGSIKEQVNVINRNRFEAKTETNISSTVSKHNNVKVNVMHMEIRKSNGSIYRRPERTNQQSNVFNGNQDPVKIILMRNEAAERRYYTMRKTKVNPIEHEYLITSGQLCDSGSPYVLMVVPSVPKHFQPRQVIRTTMGRFAKPTNKLKLANVSFKLVFVVGRDGNTQTDRLIKNESRAYGDVVQADFIDSYYNLTRKMLVTLKWVSIFCAEIEYMLKADEDVFVNIPLLMKYLKSFPQKIKGSIHGHVNNRPSVKRLGKWAVKRSEFPLPQYPRYASGNSYVISGNLIPRMFMVSEYLPYMPIEDAFLTGILAKMVETNLINHAGFTYFYDQQPIPCEFASSRRISVTKVTSLLMSRLWKTCNWFEFYCGNNSTNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DN87</accession>
    <name>A0ABY7DN87_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="120" mass="14062" checksum="C2421C65AE7AFEAF" modified="2025-10-08" version="1">MVLSDMPFEKSRLIHSRYSTMRRPDSAPAPMEEDKRDKISKEYAAFLKEQERKVGPEGFLDSTRYSHTFHVKKEREKLKTQGETSKPTVVRLSTQIDGDKKEHDKRIKIIETSIQQLKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNK5</accession>
    <name>A0ABY7DNK5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ceramidase</fullName>
            <ecNumber evidence="2">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_023659</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="2"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583">
        <property type="entry name" value="ACID AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583:SF1">
        <property type="entry name" value="ACID CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047509392" description="ceramidase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Choloylglycine hydrolase/NAAA C-terminal" evidence="6">
        <location>
            <begin position="72"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ99286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="251" mass="27933" checksum="41CEA710F70467E5" modified="2025-10-08" version="1">MDIPVVFTLSSLYILAILCCCSQGQSPPYEAECVEGKYPPPSSRRVKEYVVNLDLPGEVTLYNIFYEIFTVCTSIVAQDSNGTLYHARNLDFGLFMGWDPKNRTWEITELLRPAIVNLDFQRGGKTVFKSVNYAGYVGILTAISPGKFTLTMNERFTLDGGYIGIINLILTGKGTWMGFLTRATMEKAESFKEARAMLTSTQMIAPAYFILAGNTSGQLTTYTALMQVNQGHLETWLQYCPDPCFPCLPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DP15</accession>
    <name>A0ABY7DP15_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NIPA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_023807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIPA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ99434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="336" mass="37755" checksum="6AA440CA188699D1" modified="2025-10-08" version="1" fragment="single">NKLIYRIKYECTEATVLLVIELVQEVKNIWERLNLLGKLGCLLCILGSTVMVIHSPKNSEIKTMEELLHKVQQPAILTLVGVFIIAAIIGIVFLAPRWGQTNVVVYVFICSTLGALTVTGAKGMGVALKQTFEGEQQFTNWLTYVMLAVVAVNILFQINFLNKALDTFNTAVVTPTYYVLFNSAVAIVTLTLFQEFNQLTVYDIIGEIIGFFVIVVGIFVLNAFKDMDISLRNLPKAKKAGQEIDINDGTKMPVLKKDNDLVLEIRENESEDENDSLLLECHDSPVYVDDDHLEIGEVAFKMPKRFFSNGHLKANGHVNKLDIEDDKHFNNEVTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQ83</accession>
    <name>A0ABY7DQ83_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LSAMP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_023208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046094077" evidence="6">
        <location>
            <begin position="21"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="23"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ98835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="331" mass="37369" checksum="43502D73E8A12D24" modified="2025-10-08" version="1">MRSRTGLPLVIFVVLFAVFGLEPSFDVPVINVTVQESDVAILPCSVDYLGDHKVVWTDQWSTLLTLDDRRIIDDPRISIERPYTRDWNLHIRKVTYNDRGQYTCQINTNPVKTKTVMLNVLVTLVCNVTGVPTPEVTWYKLPNEGLHSSKERLDLEPGLFTNIDSCAYTLQQTDYILPDSSDARNIIGYGFLELDVPPEVNLPTKRIGQYAGRETILDCEITAYPHGPDDFGEYICFALNTIGQDRETMLLYEQIPKKTSKTPDDTEIRRQGNDDWTDGNGFLTSVTRGPNIPGGGSRHPNRPYQPVSMKFRSNVIKMTCVKLHGAKTLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQE5</accession>
    <name>A0ABY7DQE5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PK1L2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_029865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF194">
        <property type="entry name" value="LOCATION OF VULVA DEFECTIVE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="568"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="701"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="736"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1156"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1204"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1245"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1270"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="8">
        <location>
            <begin position="381"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ97175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1322" mass="149782" checksum="CA06D5F240209143" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DR20</accession>
    <name>A0ABY7DR20_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GPCP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_023409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM20" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="3">
        <location>
            <begin position="229"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ99036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="543" mass="62342" checksum="43DC1F0F6B332B13" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSA6</accession>
    <name>A0ABY7DSA6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ACHA7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_024964</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="572"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="607"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="38"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="115"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="383"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="578"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR00592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="890" mass="101167" checksum="325C55458A68693F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DT12</accession>
    <name>A0ABY7DT12_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_024401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR00029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="350" mass="38227" checksum="5487605F2E805E02" modified="2025-10-08" version="1">MATRQGTQGAQGSQQQPATPLSQPFIMGTPINQMNSQFYNQQTPYYMASGGNSPVLSQNMSQNITPDYVHTLFQRLDSMDNKLNQLDQIKSSVQTITDRLSCMESKIEDIETSHSFISDQYDGLLATSVHNTSDIGLLKNELKNVKCENNQLKGLAENANESVIDLKLRSMRDNYLFWGIPEGPGDMAFGGSTPSVHSGGPTYASSCGPPSTTSGGPPPAPYGANGPPLSFSAVTQPGHQDRNDPFNQYPPEVNERRRHLVPIMKQARREGNRANLVRDKLYINNRLYKAHFPSQQFELKATGLPASFGRPTLAPPSTVTPAYTRDSESTRASVPSSAAVTQSPMPSLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DT97</accession>
    <name>A0ABY7DT97_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_025307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045818933" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR00935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23012" checksum="F22154861E99BB5D" modified="2025-10-08" version="1">MRREVYILLFLGFVAVCARSPPEDKRDHDDCECNEDMYHHGDRSDVDARDDSDSHEDETDGHMDWETMTEEEKRELMRRKHEHHEENRKCCEHHWGKKKIVIALAFSSVALVIIAVVVGYCCYRKRCKKNCKTTPDSKYKESVSQILSVPPVETVSGENKYPLPEGDIATSGSPPPPYTTLPGHGVVLVSPPPYQTYPTTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTX0</accession>
    <name>A0ABY7DTX0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RL31-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_023926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ99553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="135" mass="15589" checksum="C059603060A9C59B" modified="2025-10-08" version="1">MVPVILRTMAPRKGGKDGKQKPKSTINEVITKECTINLHKRVFGIGFKKRAPRAINEIRRFAEKMMGTNDVRIEARLNKHIWSKGIRSVPYRVRVRLARKRNEDEDSVHRLYTLVTYVPCTSFKGSHTLNVDNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUT6</accession>
    <name>A0ABY7DUT6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dCMP deaminase</fullName>
            <ecNumber evidence="6">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_024448</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="6"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="8">
        <location>
            <begin position="70"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR00076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="216" mass="25086" checksum="EFEA394C081FF9D3" modified="2025-10-08" version="1">MKHEWQDFETTIIYWKSMQWIGCGYKTASRILGTDFYAAHGMPGKEMYATDILRRAHLNDNISDETEIEDDMNTMIHHPMDEKHLQVGACIVNEDKRIVSTGYNGMPNRCPDDKLPWGKGDKDDLKNKKLYVCHAELNAVLNKNSTDVKNCTIYMSLFPCNECAKVIIQSGIKEIKYYSDKYKDRSDVKASKSMLDMAEVRYRDKCRIRDTFTKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUX2</accession>
    <name>A0ABY7DUX2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PAR15-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_007803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF102">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP14-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Macro" evidence="6">
        <location>
            <begin position="655"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="6">
        <location>
            <begin position="839"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR01245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1262" mass="141783" checksum="F3D5188B4E74699A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DX50</accession>
    <name>A0ABY7DX50_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_008875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR02317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="62" mass="7267" checksum="D802CA2037AFF16E" modified="2025-10-08" version="1">MFVKDHPIDQSSANRLKRKSFMGMDNMDRMFASLNSKPRFMSMDNSFGNLQNLLLKAGRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DY26</accession>
    <name>A0ABY7DY26_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CP4V2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR01054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF175">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="495" mass="56225" checksum="5845030075974C73" modified="2025-10-08" version="1">MPVPDLPHKLHLDNLVESHAIIVLASCRMWSLHVNLQWIIQSVGWRDLVIIVVTALLPGLPYRPLVGNMLDALSGEAMSTAIRWIKQCKSLTIRYYYFGGKERILTADPKLMGKALFFLSGDVHHSMRKLLNPAFSINVLQNMLPVFEDKAHSMVSLWLEECRQAGNQPVQINVQDFMTRITLDTVCITGLDYNIHAIGSGDTAGVKIFTRYLRQVGGRTISSSFIPFYYHLPFAANRQRWEDEKYIISLIKERIQAKRQQYWDGCENTAAVKDFLSLLVLARDEDGQSLPDNLVFQNVTGIMFAGFDTTSVTLTWALLLLASYPDIQTRAREEVLEVCADPTQPLTHETLDKLGYLNCVLKETQRLYPVVSNTTRRALEEDNIDGMEIPAGTNIVLHLGALHRSEENWPDAEKFEPERFMSTTVEPYHHLPFITGPYMCIGSKYALLEMKTVLASILREFRLQLVPGYTFRRIQALSVKPHPPLMLAVTKLSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZ82</accession>
    <name>A0ABY7DZ82_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_008471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="75" mass="8664" checksum="111DF03CE0B86323" modified="2025-10-08" version="1">MFNRKAKPYWTEEVKAAHAQARRARHIWLADPAVQCQTHSQTKNKPNALSGEYSGIVANPKKINYMTNLIEQQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZH2</accession>
    <name>A0ABY7DZH2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GCNT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_008224</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297:SF191">
        <property type="entry name" value="PROTEIN XYLOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR01666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="449" mass="53124" checksum="E120D26EA67F6232" modified="2025-10-08" version="1">MIRVRRLRVWFLLVFLVFFVTVPYFWMMTSSKVIHKDVFYNEPMRIKEGDIAGTIPKEDRSSNELNVIQYFECEKLFANDPVEMSKASAFLQLRNFTFPRRRDENYIDLTMNCDIFKESRGYFVYPPTQEEKSFPIAFNILFHQNVEQLERLLRAIYRPQNQYCIHVDGKTSEDVLNIVTQIAYCFPNVFIASELEIVIYASATRLSADINCMKDHVNNRFQWNYLLNLASSEYPIMTNLQIVQILKQFNGSNDIHEVFSTMDEGRFKRKYYTFIDLYGKSGYMIHTDKQKEPPPHNLKITKGNAYNIFSRAFVEWFLSNQMARDLLGWSMDTLTPDEHFWATLNNIYSNPHLKTPGGYTAIKASNKGVKRRCTREVKSEFHVRRRDRALPVLDLPNIKDRYEIIANKFDIEYDPIAYRCMEEFTLNNVLNEKLISNPKRYRKLALLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0L4</accession>
    <name>A0ABY7E0L4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZO28-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_009039</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR02481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="387" mass="44249" checksum="3C0F319D4DE1826E" modified="2025-10-08" version="1">MCYEEPTQTSNLNKIKVEIKAREEMEALMSHIMKSTAYRMHQKTRHLPLDLSNYKRLDHTCDPFVNQEDLRSETLDIALSSPIVRRCAPSAGTVLESDSSVTESSGYVSGLSDDSVQTNREFKTPSPQLHVAHAHPFSIEALLADVTSISGETPSAPAIITSTLSPYSASMQHLQQVTRQPKNEPSFRFSKDADTFWCHACNALCVDGRDAQNHQRIHQLQDAPIGLRKSLFSKHDYVTRHIRLNDERFQCGLCDKVVAHCFFTKHQRLHNGYFCEICRNEFSTNSRLRDHMNVHSGNTPFTCSICDRKFSKRSSLTQHYRYHRDHRSFKCGYCAKYFNSKYACAVHERLHTGESPFRCTVPGCGNAYPQKIQLKLHMCSHKMSPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E178</accession>
    <name>A0ABY7E178_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COLA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="16"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="203" mass="22970" checksum="BAE73DB1B1EAE110" modified="2025-10-08" version="1">MYVYDVEYYCGNKPADVVFLLDTSNSIWGPDFTRQLAFVNNVISMFKIASNVTRVGITTFSSQVHREFYLNSYFSKDSMRSRVSSIRQTHGYHTNTGLAIWHMRHRMFSPRRGSRPDVAKIGIVLTDGQSSSIGKTLMEAKRTKRKKITMFAIGIGSNINERELQGIASSPSSEYVFKVDGYSALDAIKNSLAVRTCRGDNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1A5</accession>
    <name>A0ABY7E1A5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAA25-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_010351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR03793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="753" mass="86531" checksum="84AE607C54323757" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3W0</accession>
    <name>A0ABY7E3W0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_009754</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="13">
        <location>
            <begin position="527"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR03196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="649" mass="74387" checksum="64FE852B16E4F495" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E449</accession>
    <name>A0ABY7E449_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S17A5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_010547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR03989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="357" mass="39662" checksum="64BE59E00387CAEB" modified="2025-10-08" version="1">MAEGALETEKGLLNETKKKPKKAACLSKRWTIAYMGMWFGVLGYGLNTNMSVAIVCMASTTHNTSSSDVTSPLSEGNATDLSFLKNGTYDIGHAEKHNETQLKDNIDDHDSITYIDDDNQITEKGNERNTVNVDILQCAEIGSESYKQNAEFSWDKRTQSFILSGFFYGYIFVQIVGGWAAGRFGGKLMIGAFMGLGSLVTLLIPSLARTSPYALVAARVVIGMSAGLALPGWFKLTAVWARENERTRFISIIPTVPWLDMVTYTPIYGPLVAHICDTWTFYLILTCLPQYIKEVLKFDIQSQSSEEWRIVLLTAAGVSVFGTIVYDLLASSELAPWSDRMEFEIEISLDKDQKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4T9</accession>
    <name>A0ABY7E4T9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_008729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR02171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="84" mass="9741" checksum="6B7DE143F8E81456" modified="2025-10-08" version="1">MQSFGHGLERRLQQIQYALSGNFGVYTQWENFNPDSSGVIKYESLIDRTEAQGVINRNEALQVYTKSMMGELSLTLDYLQYLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4V9</accession>
    <name>A0ABY7E4V9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RU17-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_008744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR02186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="95" mass="10481" checksum="31242108B61C9245" modified="2025-10-08" version="1">MLIQGCSTPNSGNSNIPNGSLGPDNGSSKLKVMLIQGCSTPNSGSSNLEQWQLYLRIYPLLQIKLASDKISESGKPRGYAFIEYEHERDMHYCSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5W1</accession>
    <name>A0ABY7E5W1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transgelin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_020752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="10"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR05383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="383" mass="42423" checksum="8D53A75C8D2ECBA5" modified="2025-10-08" version="1">MSKVHGKYDLQAEAEVRTWIQQLLGEQIGEYELEKRLKDGTILCRLIKRLFEGTPADSLPAACRTVNMRFRPSDKGAVQMENIEIFVRAAAAYGVPQSGLFACNDLYEGKNMPMVIATILQVGSEAQRWKFDGPTCGKKPVEKKRGKFTRQQLREGHSILTPQSGTNKYASQKGMSFGSVRHCADIRADDMNQEGQGEMSLQAGTNKFASQKGMRIGTQRHISDIKSDEMCNEGQGELGLQAGTNKFASQKGMSFGSVRHCADIRADEFDKESSGDVGLQMGSNKFASQKGMSFGSVRHVSDIRADDCDQASSGFVNFQSGWNKGASQSGMRGFGAARHVTDIHVTELCDEFEPEPGEEGYEEWLLEQQMKQQQLDEQRESAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7W7</accession>
    <name>A0ABY7E7W7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="63" mass="7397" checksum="E1D4EDF7627724D0" modified="2025-10-08" version="1">MKILYQSDLSGVSAQNKLRISAYSAGIQWLKRHRWNYQKLIQTAGPTRDLHHKALFQQRVPFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8M7</accession>
    <name>A0ABY7E8M7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sodefrin-like factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_020704</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00117">
        <property type="entry name" value="TFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF2">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047076729" description="Sodefrin-like factor" evidence="4">
        <location>
            <begin position="19"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR05335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15744" checksum="BC787F1DC24F804E" modified="2025-10-08" version="1" fragment="single">MLVSVIFTLLCILSLAMSQDKPRIKCYECINLKDNSCGRTFTGNDNYLIECSENATACQKLEYEDSFQGRHTGGLVVSRSCWESSSAEQYVPDTEKCEDIDRTDESESRKNPIPVQNMRGVARVSKATTHVTSANFVLDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9Y0</accession>
    <name>A0ABY7E9Y0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ETFB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_020800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR05431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="207" mass="22561" checksum="7E03305C5623A785" modified="2025-10-08" version="1" fragment="single">MLLEKVRVKPDKMGVVTDGVKHSMNPFDEIAVEEAVRMKEKKVASEILAVSCGPQQCQETLRTALAMGADKAIHVLVDPKDYTNMQPIHVSKLLAKIATDEKVDLIILGKQAIDDDCNQTGQMVSALLDWSQGTFASKIEKKDGTLDVTREIDGGLETINITLPAKPGDLGVEIKSTQQILSVEDPPTREAGQKVESVEELVGKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAI9</accession>
    <name>A0ABY7EAI9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CD80-like immunoglobulin C2-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_020803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CD80-like immunoglobulin C2-set" evidence="6">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR05434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="165" mass="17827" checksum="763104186EFF32F8" modified="2025-10-08" version="1">MVFPVGSYVSVIENTARQFRCETSAGNPQATVEWYKDNGTLDRADDTEITTGIEKDTRASGTLIVNIGKLTLSVLRSDQEVGVYCKANNGGDWLYSSTVVLDIQYEPTDPKVSYKGSEVTSPVRVISGRSMTLTCSSTGNPSPLTLGCTLVETHIVAPRSLWPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAZ8</accession>
    <name>A0ABY7EAZ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="62" mass="7268" checksum="859761BD9451E617" modified="2025-10-08" version="1">MYRMSHDAQSDSQEKHGNIHPWGIEKRIDTDWQEELESVDVNTSSKNKFDISEMELGVEPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBP9</accession>
    <name>A0ABY7EBP9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="251" mass="28842" checksum="59D4DE94291E0FCE" modified="2025-10-08" version="1" fragment="single">MTRCEMFVGDASGSCGSLTIMKPTFVDRNVTLKFIPRHRWIANIVWMYTHEWDVTKEHTVKGIEKHFQQNVEDGLNYHTMMFFAEDSRNNSKFHVQCSDGKGNSSTNTVKLHLHEIRLDCGNLVLLSPEIKYGTNVEIAYYPSDSTLDFENNLNNCTWLKGLGQPLYLRNDTFEERKVSDYLYTLNLHNFMEKNAGHYALKCGRSVAHTTNWLHINVTDKQLIGPIMDNCVYGNADTIIYCNTSRTTGKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFB7</accession>
    <name>A0ABY7EFB7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="170" mass="18424" checksum="B07A3D28DF001786" modified="2025-10-08" version="1" fragment="single">DGISNDIDDVLERLTSIGHSLLTVVFAGECFNQESTGFVGLKNRTTSLSRKHSHFVSFSRENGQTIDLDRLACETLAVISSQITEYMRRKDIITKKPSFTSLPRSNSSASLINTSQTEGRGLSRRSASRTSLISRNSMSNATDPKCPTCGSVLDNGSSSVITQSSTDVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFC4</accession>
    <name>A0ABY7EFC4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="276" mass="30681" checksum="1193A4F3BA3D2173" modified="2025-10-08" version="1">MATGGGPVGKITLAEEIVLEFLKDKPQLIGIPGGIESGVIEPVEDAASVADLVVQQAPMTESKHISTHQETVSVHAIEHPSVSHEHPDEPRVMQTNTKKRRRKCMDRIELTEELHDLEVCRARKEIELLDLKIAQQPKKKYNENMATGGGPVGKITLAEEIVLEFLKDKPQLIGIPGGIESGVIEPVEDAASVADLVVQQAPSRRKCMDRIELTEELHDLEVCRARKEIELLDLKIAQQRELFQLKKSVLENAMRNANMDFNITFPGLGNESYNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EG34</accession>
    <name>A0ABY7EG34_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_017342</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="5"/>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="15">
        <location>
            <begin position="15"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR07384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="381" mass="41889" checksum="563C2E1A6EE282D9" modified="2025-10-08" version="1">MAGQKQQKDIGLKILTLNCWGVPVPVVCKHRNERMPAIGDAVANSDLDVAVFQEIWHKGDFDILKQRISKTLPYSHYFYSGSIGSGLCVFSKWPIGQTLYHRFDPNGYAHKVQHGDWFGGKGVGLAVITVGGVTLNVYITHIHAEYNRENDEYLAHRIAQAFSLSQFVKLTSLGADLSLVCGDLNLEPVDLGYRLILTNAGLGDCWLDKMTSDTSDKAGLTCDCPGNSYCPSKSAGKRIDYILYKAGNGVEATVSKCDVTMGRVPGKAFMPTPDPKTEVTPLLEESLGLLDEGLTVTRSGTRFFTIFAVLCLLLAYIITVVHIPYPLDFFVGVFRVALILATGYGVVQTLVMIRSEVHGLEAAREDVKNLLQHLNLQIDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGK6</accession>
    <name>A0ABY7EGK6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BIR7A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_018030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01282">
        <property type="entry name" value="BIR_REPEAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="706"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR08072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="753" mass="86605" checksum="432DBD03E3F5643B" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGV0</accession>
    <name>A0ABY7EGV0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">PTPRQ-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MAR_019048</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0768">Sushi</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1888"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="56"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="113"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="170"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="266"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="323"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1097"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1327"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1433"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="13">
        <location>
            <begin position="1938"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="14">
        <location>
            <begin position="2138"/>
            <end position="2214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2226"/>
            <end position="2262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="2226"/>
            <end position="2237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2238"/>
            <end position="2248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2252"/>
            <end position="2262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="2262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAR09090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2262" mass="251899" checksum="0D447C1E6D0BFF8F" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGX8</accession>
    <name>A0ABY7EGX8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MSRE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_017612</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="5">
        <location>
            <begin position="99"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR07654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="345" mass="37836" checksum="8880BA3C0A43AFE4" modified="2025-10-08" version="1" fragment="single">DICSFEAGTCGWRNVLEEDDIDWSFGDCSHFIHTNMNENGIGTSVSQQQNTTDNCAYIESFGPHSAGHRAMLRQAVMIKTPVVISFQAFINTDAVIQNIQLVDGPTPMSGRVEVLINSRWGPVCVDPADIFFAAVVCRMLGFVTNNAQTLNLTVYQRGFEAQPIWLIGVTCNGSESRLEECGRSDVLNACTHSEDVGVSCNNETVTTATTATTASLRGDILGSHTNNKTLIIVCSSIAAAIFSISLCCCGFCWYRYKICSKVTTGQQISETQYNVETNANTLITTNPLQSDGTHPKSDDPPPPYSEICFLPSNDGYTMQVHYQLLSEPPSYDYVMVSPRNYNVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHY7</accession>
    <name>A0ABY7EHY7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab3 GTPase-activating protein catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_034683</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Rab3-GAP catalytic subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045700">
        <property type="entry name" value="Rab3GAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045698">
        <property type="entry name" value="Rab3GAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026147">
        <property type="entry name" value="Rab3GAP1_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422:SF9">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19533">
        <property type="entry name" value="Rab3-GAP_cat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13890">
        <property type="entry name" value="Rab3-GTPase_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3GAP catalytic subunit conserved" evidence="11">
        <location>
            <begin position="425"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Rab3GAP catalytic subunit C-terminal" evidence="12">
        <location>
            <begin position="506"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="274"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR09607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="651" mass="72496" checksum="8B8434630F0C3F98" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKP0</accession>
    <name>A0ABY7EKP0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BON1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_017709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copine C-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR07751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="212" mass="23260" checksum="505790D0E4A2329D" modified="2025-10-08" version="1">MEIGLACSLAPQASNGTPEQTTSLHDVSENKSSISRYKKAVKQLRMSGPTRLKPVISFAESLAVREPTQDSQVYHVLLVITDGILNDIDDILERLTSISQLPLTFVFAGVGLADFKLLITEYMRRKDIIPNKPSATSLPRSHSSASLINTSQTEGGGLNTHDDDDDDDDDDDDDDDDDDDDVRVYNLCGISTEIKPMVTGEILVHLNQHFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EM40</accession>
    <name>A0ABY7EM40_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="419" mass="47565" checksum="1177C8D9C5373663" modified="2025-10-08" version="1" fragment="single">NLTIFQNPITPRWSGWFDDLSGLLEYRIEAFLLEPNIHDELIERNPLSPVFTYTENNTNNVRSPTFTPPRSGMFSVLLTAADRANNTKIARRLVLFDDSSEITITKPGLLTKIPNAEDVKHTVVGDGGLYIVSAVKETGFMWQTSAKDSKSRIEINWENHFINKVHDDGKLLNKVLPYPTQFQDLEDNGIVRSKKYVAIDDNEGDRTLKAIPNKHGLVKFELNRVFTDDRQIPASNWKPIPLEESYVITEQLDDGSHVRVWLRATDAMNNMAVDYTEVHIDNTPPRVSDEYLEKNVENGTYTYTSRVTFQASDDGSGVHKLQLTLYVGKSLTPKKVHNVTSNRIDTAGICDKDASCNCVLDVCYRLQQMIDLDNCWFLVPKEDLNKSGTLQVTTYNKALLSRTFNLTITHLHLLNGLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENM9</accession>
    <name>A0ABY7ENM9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VLPF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_035502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="914"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="980"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1174"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1295"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1593"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="674"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="745"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="761"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="880"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="925"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="985"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1177"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1306"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR10426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1652" mass="183341" checksum="7EE66CD16A58FAF5" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ER36</accession>
    <name>A0ABY7ER36_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd04491">
        <property type="entry name" value="SoSSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="351" mass="39087" checksum="8E71327745B82AD3" modified="2025-10-08" version="1" fragment="single">TSEMDLSTLMKSVVGHSPYPKKVTVKVLCTDPATTYVNDKKERRELMNTVVADSTKAVKCVVYDSKKFHRFATGSTIILRNIIRKPEGIAVTSATVIFPAAKTLDLPPSIEKEGIAILHPPPADVKSVADALASPTKTRVSVRGKIVQEEATRYVTVKNEDNVKVKNIYLEDTTKKCKIALWRDLADQPVRPGDYVELSDCITNTFRNEVSLSTTSKTAITKTECPEETVTWEIESVCIEESTATMLLKDDRVVTAPVKSLLEAFPECMEEDLEQYLVSMCNPTMVVKCTFKGMRIVLICFNEVPDPNAGNTKPIHTCTAPVQNETYDKSRKVILCRLSSDPVRNVYEDMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESM4</accession>
    <name>A0ABY7ESM4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="451" mass="51594" checksum="15E2ABE06D1647E5" modified="2025-10-08" version="1">MPVRIKNNDKCANVDFPERTQAKLTLNIRYTLAFFRNSSRLQTLQRSVLLTRSRKFKQLNCWLPISVTNHLHIAINVTVAGNEYNTVATITCKEGCKSDDIMFNTSYLCSKNGTLNHKPSARVLRVSFAPLDKGQTTLKHWSVTNSSISFQFNDKYNGIGRLEVSYRQLNADLYCYVYNDIRIVCDHVKSNSDPYVVEKLMGFHREYKDRRDEVIRNCILNMHKTVSEPEAQPLRGHCNGFSSERETSFLRNSTHKSSHNRIASGSSWASSILSQTNSGLPSKASSGKKLQRSVTQAMLEDMDESNCSILFLTLPFDQYTRDVTELLRNVLSIEGGIPSQCCFDPDVLSDYQINRFTFIEEITGNTNKILVFVFLTTLSYGTKEEKLIHDLLNHCLLKQRIIPQCKVVFLHLTDDNSRLETRYHGQHIHLKNDNASKKFLSVILRECAINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESN4</accession>
    <name>A0ABY7ESN4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NEDD8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="67" mass="7770" checksum="035311A635ED50DF" modified="2025-10-08" version="1">MLIKVKTLTGKEIEIDIEPTDKLRLESCLILALQYLLRFLLRLLDRIKSIKDDVALKNAVIETDFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUI1</accession>
    <name>A0ABY7EUI1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TBCK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_026383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF168">
        <property type="entry name" value="TBC DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="77"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR12203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="301" mass="34630" checksum="9C7E8EBFE0DD2680" modified="2025-10-08" version="1" fragment="single">QRLSDVDEKSYYPLLEDEKTLNDTLPTSLSSVDLASTASLPIVIKEKDVEYQFHRVILYERLIQGYPYKRAQILKEARVDIPPLFRNLVWATLLEVEGDIQAEYDSIDKETPTGTDRQIAVDIPRCHQYHELLASPTAHAKFKRVLKAWIVSHPQYVYWQGLDSLCAPFLALNFNNEEYLPVFSHLIAFHDPELSNHMEGIGFIPDLYAIPWFLTMFAHVFPLQKVFHLWDTLLLGNSSFPLCVGVAILQQFHDRLLSYGFNENRHTSVCKGLHTNILQDTKECNLPPTCKAGCKEDRREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EW85</accession>
    <name>A0ABY7EW85_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S35C2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_027146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd21092">
        <property type="entry name" value="TPT_S35C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="49"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR12966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="414" mass="46795" checksum="CFE22018FD5DF673" modified="2025-10-08" version="1">MMTQSHKTLRDLETAAHLKLVKLRTSVGPEAEKVKKSLISVAFVTLAVKTVFLVLFYYVFSIGLTFYNQRFIKHWNYPLSLTMAHLLFKFSLSAVVRVVMELVTKKPRVVLPWGPYCKRVAPAGITSALDIGLSNWSFEFITVSLYTMSKSSAVIFILMFAVIMRLEKWRWSLLFVVLFIATGLFMFTYHSTQFNLEGFSMVMTASVLSGLRWTLAQVVMQKNELGLHHPLDTMYHIQPWMIVGLIPLSIAFEGVPLATTDQFFRFNDYEILLRNCSLVLLGAFLAFMLEFSEFLLLSQTSSLTLSISGIFKELCTLLLAHMINGDTMNAVNGVGLFVCLLGIILHVVLKALHRQETSSPSQNGAERIRMLNLDNTANISEDDEDEIFNYEVWLKPTLILQSSNSGFSSPPLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EX60</accession>
    <name>A0ABY7EX60_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="411" mass="45012" checksum="9F63B91527775224" modified="2025-10-08" version="1">MAASSSPKSRSKTLLTIGDIKKSLIENDGQPVLYKSISNNNVKLETVPTTNGSNNAQNHNGAIENIKKGKKSRKRSRSSMKVKKGRLGNLLSGVQSGTDRHSITSVSSRGSHIATPNRVSSEPPSKIGTKVTSTAVLTFDRHGTGNGFGHSNHSHTGLPSTSRQVTSMYPPSSFISNSAKSNTSVSVCNNTHSRLHVRDEHLNDNDEANTVDGLLSLQAQGKPIVLYKLDVAPRIRSASSIKSDSTIKTLGGKETKEIMDKNTELTLTAFTCAVQQAKSQSNKPTIKYHNSLSPTAKVLSDNDYKSKEAGLASIYAPVFQTADKVSAQVEELKKVKKIFLPVQSEKAEQSFPAHPQPHPLQSQRAVKGRLAAMEKEAQKKREKQKQENVKMEKQMVKDREKQLKIKQRREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EYR0</accession>
    <name>A0ABY7EYR0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28154" checksum="C901D01DA07E2B7B" modified="2025-10-08" version="1" fragment="single">MYSCIIANGLTSEFFPVLQGIRQGGIISTWIYNLFINGLLDSLERSGQGLNVINVITSNTTLADGIALAAISPNGPNKIERTDKIRHVGIQINDKMTDNDKISGACKKAESSFYSLLSINIGTFHINPLTSASLVSKICIPKLLFGAELWNNLTKSNCMQLERFIRMAAKTIQRFPIRTRTDICLAMLGWKRIESEINLKKLMFLERLCNMPTTVLTKQIFNKRLALFSCITDKCIQKGFVPDIIRILSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0U1</accession>
    <name>A0ABY7F0U1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014988">
        <property type="entry name" value="Uncharacterised_YqcI/YcgG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08892">
        <property type="entry name" value="YqcI_YcgG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="330" mass="38099" checksum="F77474CD2677EA50" modified="2025-10-08" version="1">MNQLEILEDYAIAIIMKILHDDDDDNTDVNHDDDDDDDADLDDDDDDDDDSSLIILPKYLTGENWKRNDTEKPKKMKAILQELYPTPPEEETSNQVVQGVMSLVSYAPENTESLKNFQVVKENSNCLFAKKAKLWGSPDWNEKLKLEGNISRLVPMFLKFTILCSQERLDGFLLELPGFPFGKDIQAFGDALYKVLAILSDFDPAGFHCMDKSYVGKRGWVFEFNKITFFITTFAPFYPENHARYSHGAENCYIFFQPELSFAFKDLPPDTSETNWTEPKTVRDRIRIAFKEAGRRYTVPEDPSSPMALDMLRPINEGEGVYEWWKSEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1I5</accession>
    <name>A0ABY7F1I5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_005031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053071">
        <property type="entry name" value="GPCR1-related_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023">
        <property type="entry name" value="SEX PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023:SF1">
        <property type="entry name" value="SEX PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="95"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR14926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="407" mass="47507" checksum="51F24C733B70E81D" modified="2025-10-08" version="1">MYGLKERTMASYDAYGDYHGNYTDHSYTNGANNTDQETHTHSQYDDYHYSYDDYNLYSFDDYDMLYDDHIYEIFDFEIVIYGYLWPILVIFTACCNLLVIGGFLRKRMRNPTNLILVFIAISDSLTGIVTLPATFYVFSGKHIFLSKDWCNVTMVTRLYISRAFHTISIWQTVLLAVHRFLQIRHPNLASRLCTTKKTLAAVGIMYLVSFLLHMFHAFDIKTNGGFCQWELRKPCGWACVYIWASLILNHVLPCVILVVLAYKMWKSLRKLNVNVSNKTVREKKERARKITLVVVLILVIFLVPELPYGIYFLITMILKLVKGKILPLKTNRAVHTAYEVLLVLSFHLNFWVYCAMYRSFRTSLKTICRKLQCQPEPPFHSEENMTSSINKDYELVGMTSDTQQENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F258</accession>
    <name>A0ABY7F258_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">STK3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_030861</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.170.10">
        <property type="entry name" value="p53-like tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024205">
        <property type="entry name" value="Mst1_2_SARAH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036674">
        <property type="entry name" value="p53_tetramer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11629">
        <property type="entry name" value="Mst1_SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="11">
        <location>
            <begin position="355"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR16267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="409" mass="46022" checksum="A39A1008E0E1FCA8" modified="2025-10-08" version="1">MSNQSELTKLSDESLARQPDEVFDIICKIGRGSSSDTSLKKLSEDHLAKPPEEVPVDTDLQEIIKEISIMQQCDSPFIVKYYGSYFKNTDLWRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPYWMAPEVIQEIGYDCVADIWSLGITALEMAEGKPPYGDIHPMRAIFMIPTKPPPSFRNPDRWTPEFIDFVSKCLIKNPEQRSTAVELLENAKPVTVLQKMILEAREIQEENTLNTVNGDDSGEDDAVEAGTMVRNDDGTMKGSQAGTLQSESGTVICNSENSTMMESDLGTMVINESDEEDDGTMKRHSTGTGGQEKYRPSFLDHFEKKEAEANVAQQRALRNLAYDDLERRLADLDPEMEREIDELRARFHAKRQPILEAIDAKKKRQQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2F3</accession>
    <name>A0ABY7F2F3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="74" mass="8670" checksum="B05C2DBF1F7E3710" modified="2025-10-08" version="1">MFQSNLSAYDKDILESAAKDHFEQYTPLIAWIIIQSVQKDMSTTGVAVQYQVDKAFRNLCFHRFEFYVHTGVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2P3</accession>
    <name>A0ABY7F2P3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CCKAR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_005154</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="23"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR15049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="434" mass="49168" checksum="E5E766D9541F0656" modified="2025-10-08" version="1">MEDPAVVTVMMMLSLFSICGTIGNSLVLYIYSHKKEKSTAGIFIMSLAGTDLFTCLFVMPFTEAVVYMNYMVRYDVPCKIYMFFITCNVPLAAFIMVAIAIDRYFCICHPFLHVLNIFRAKVIVLCLLLVASTFGVITSLSYGVYSYEQIVPTNKTLASLSETMMYNESENYGQNVTFIAGGHRVSANCSKELLGKLHVYNNNNNKTEAHAGYDLLYTGLCAPNYYLTGPHFLNIYQRVYAGTYLLSFVVVFVLYGLIYRSIYKHRAKRSKRKRSSLYPSGVSHVTSLVPPCIEFSNIETKFTAATHVNPHSGRRSDPNHENGENDDVDAETNIELQPMRPKPRKGPRAISIKEKTLLANIRTAVMLFVVTVVFLVTFLPAWLMGLQAMEFNAVIFYMYFVYHTANPFIYAFMNKSFRDDLGKVLKCQSIPLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2V6</accession>
    <name>A0ABY7F2V6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MRRP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_005507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF5">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="5">
        <location>
            <begin position="230"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR15402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="415" mass="47921" checksum="21876433DC1FB0AE" modified="2025-10-08" version="1">MFQARLVFRRILSTKQPCFSKSLKTFLRRRQFCSSADVTSITGNTLNNAVDNHSNTADRINSSADRLNSIAIDQNSAADSEISSGNRVNERVNGNISDSDNEGVPLNHYKGNIRQHRLDKAKEFMDNLSPELIEKKKQIEAIIEGLIVSNALVPDNIDLIDWQQLLGRNATYHSIAKYCKYLFLAETSKKNDQQKKMARRLELQERNKIPMPEDQFKYNLPLFQREIVKKNWSRLRCLTSSIPMILDFNYPDCSIREKTQSMSQLSEIMRVNYTHPQPCHLHMTSAMDNDFLKEFHELNGDVLCGTVHEKPFWEVFPKDNLVYLTPDGPALKHFTGNEIFIIGGLVDIYDAAPVSYIKAKKLGIRCASLPLMEHLLRKYFPKTQEGWRGKQLAQERSRDSSFVKKIKRYEQHITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3B1</accession>
    <name>A0ABY7F3B1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TTPAL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_005657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF208">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN DDB_G0278031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL/TRIO N-terminal" evidence="2">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR15552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="275" mass="31867" checksum="1BB4ED4B7B5549C0" modified="2025-10-08" version="1">MASEAGDENYVSPLDEASQQKCRNELNERSPADTLIAVQTLRQWVKEQDWLKTPTGYAFLLRFLRFRKFSQLEARKALEKFWTVRTGRPEWFTGGDPADPVLNKIDLQSKTEGQAWTPAGMDMEYLKQIGMSKVYQVVTLVYDWLVWDEHVQIEGVVTVVDYDGLTMQLVTTFSNREFKKEYMEYFQFHLHGKSLVKIFEEVGYECMPDEYLPDDYEGPRLGTCADIIDEMIEDLNKPEFIKYIRDLSSGKYGVDKSRVPAQTEVVGSFRKISAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F459</accession>
    <name>A0ABY7F459_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TEN3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_030578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR15984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="362" mass="38477" checksum="BA054CBB218D0804" modified="2025-10-08" version="1">MLQEFKYWLLAVVVVVAMSYVSVEGVRSNGNIAFVLKNKHTATPPMSKVKLKFVHSKLENVVRNFDKKCNVCVVLAPGTECPEGNVSFCNANETCTDNVCVCKPAYTNVSSDCVPRGNSDPCSVTPDCQSGNLGDKGACNNTTKMCHCKDGYSWKGDNCKANGYNDTCNTTPDCQLGSLGENGTCSMDTKMCHCKDGFSWEVDMCRANGYNDTCTTDTDCKSGNLGDKGACSTFKCGCKAGFSWTATECKANGYNDNCTADTDCQSGNLGDMGACSTGKCGCMKGHSWTAAMCKTNEYNDTCTADTDCQSGNLGDMGACSTGKCGCKKGHSWTAAMCKTNGVSGLTVSITLMLGVLLSKRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F632</accession>
    <name>A0ABY7F632_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTN2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="257" mass="29598" checksum="EC639213E02EDEB0" modified="2025-10-08" version="1" fragment="single">MKNFASQYFLCIGVGRVTYSLDRKLLQHTIETRSKDEIEAVERNKHHLSKNRANADIPGKLPKWAKSSFRMKKRYLVAQTPLPETVIDFLTLAVQERCSCIVSFEADMDKQKNIGIYYPAANQEVLKKETFQVSCSREENKTFYAERTLTIQHKGTSTDRTIPHLQFTDWDEMENIPRSTTKFLSFLNVIDNVMKQQDDGPILVHCVNNLCSVMDASWNIFVRSTSTPTLTMTPGNFKVLSCRLSSVKREIFKDIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FB66</accession>
    <name>A0ABY7FB66_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_000680</name>
        <name evidence="8" type="ORF">MAR_002481</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46726">
        <property type="entry name" value="TWO PORE CHANNEL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46726:SF1">
        <property type="entry name" value="TWO-PORE CALCIUM CHANNEL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR18842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR20643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="135" mass="16147" checksum="6056B566FE340088" modified="2025-10-08" version="1" fragment="single">MIAKNVRPSVPQVTMPVEALCLIYFIIRTVHHYHWRRTSRFFRDLKNICIIAIIALIVVDMIVYLIWLRAVPNGHHVRFSRILRPLVLVNFSDGRQIRRAWRNMRRTIKEIIHVIVLFYFFIFVFAVIALQIFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBF1</accession>
    <name>A0ABY7FBF1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CBPM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_001336</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF84">
        <property type="entry name" value="CARBOXYPEPTIDASE M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046408236" evidence="9">
        <location>
            <begin position="17"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="10">
        <location>
            <begin position="21"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR19498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="389" mass="42640" checksum="AC32FFF952EEEEB3" modified="2025-10-08" version="1">MLVCLLLLASLLGSDATLSFDHHDNAALEAYLVSVNQTYPDITNLYQIGTTGNGKPLWVLAIGNSTESTDLRPHVKYIGNMHGNEVVSREILLHLIELFVTSYGQNATLTRFLNTTTVHIMPTMNPDGYSNGIVGKCLGYDGRGNKNNVDLNRNFPDLIFDKSVKPVQIETQAVMDWLPEHSFVLSANLHGGAMVANYPWDLYLESSDTPPGSGISPCPDDDTFRFLSLTYARGMQDYNYIKEGIFEITLEVACCKFPQADTLPGFWTANKDALVNYLLEAHKGVKGYILDENNNAIDGAELTISGREGVPFMSKHGGQYFRLLMPGSYTLNVHYNNTTTSKAFKVIDGSVTRLDVQINHGSTGSGNSLQASVAAFLFAVFASISTLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDI1</accession>
    <name>A0ABY7FDI1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20956:SF12">
        <property type="entry name" value="FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20956">
        <property type="entry name" value="HEH2P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="370" mass="42661" checksum="3474A41FEA3F6CA4" modified="2025-10-08" version="1" fragment="single">FAKHIVDWLNYILLNHISDKQDVNPLKYSLFFNLRKGRLTHDCNHVAYMTEHLYIASDYTVYQYTRTGQRFATAESFLDETSNKVSALDATYIVGPSLNDSREQLFDVTRDGPVATTVIHERSIREPMLSCSVVDEAEVEYEVVEEGSNRKRQKLVSSGGFSYCVKRERPIPAGSRDAASGEKTCLAMRRLISGVRGAKEHCHPADPLIRKRVLLTRDVSESVFKDGEFNIPCPSNLMRRVNRSRQKVRPKDPTSLDFEVDTDYLLESFFIGDVRVGDERHLMFSTPSQLKFLGQARRWYLDGTFRVVNRPLTQLWSVHAFLQQGESVKQVPLLYVLMSKRRKQHYVAVSKYHFKICIYVNIIIIINNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDI9</accession>
    <name>A0ABY7FDI9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LR74A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_000669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="491"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="523"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR18831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="592" mass="66320" checksum="0D4E7527A6CAA3AA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEV7</accession>
    <name>A0ABY7FEV7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="415" mass="46740" checksum="09B3E2DDBD0B2F66" modified="2025-10-08" version="1">MLLYQECPFCNQPMVDSKPTVALRDKGCDTINRTGRDRDLNIHDSPGQIVHTECRHDFIDPRNQCDNNSFDNNYVTQLSHLINTCIFCGKHAKLNSKKRGADVYPVRTIEFQNTLKQKCIERNDSWSNENIVVLDLPAADAVYHQKCKVNFRTTRQIPRCYSYTYETPPKKSPGRPDYVHEGNILTLSELVMVMEESCGERAYTKRHLKSKLLEHFGENISISTLEVKEDKKNIIQEAAKVIKTEINAIESNKLIFPNASSISSTTENNKYIPESLIMLLSSMFSSSDDVKLASNGQALSSSMSLQEHSCSFTAIPRGSATSSVRIKILGRSSKQDGIFCIIFFPRKFVAENVDHNACILDGHGTFYGMGIIACKSHGSKVKMPIPKKEIHLEEIVEPGKISIKYVSHSNSVEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHZ7</accession>
    <name>A0ABY7FHZ7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FBXL2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="402" mass="44525" checksum="4A42B304263C983B" modified="2025-10-08" version="1">MVKTLSDISLNFIQNNLHKLDDVCKLPTVYKELLLEQIAWHDLLTESYVPHMTKLFSKSLTKINFYKCEQISDNLLKSIAASECKLESLSIIKCFGITGVDTLAGRNRQIKELYLWGVAEHTHRSRSHEERMHAYEVLDTKLNQMCDECLVAVASYCPNMRILNLHGSSKISGQALTKILVECLQRLRRLKCVKLCGVPALNDETLAQILEHIGAGLTLFDISGSVSASLTDKALEAVTQHCSSLEALHLSLIPNMTGTGLLPLLRDPVRATRLKGLAIGMKKLSYEVLSEVVAQCSNLERLHLSGVTCVDDEILTTLAQNCPGLSRLLTDASIFCLANCCPQLEEIYMNGCANISPVAVRYLKDCTIPRLFVGHATPNAAPDQLMARNLDTGQFCRVDKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIE0</accession>
    <name>A0ABY7FIE0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_014675</name>
        <name evidence="2" type="ORF">MAR_030070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOCS box" evidence="1">
        <location>
            <begin position="379"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR20701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="417" mass="47802" checksum="1E791ECA65F124E8" modified="2025-10-08" version="1">MGAEESKPGSPCFGLMGPSSVVSNMNRQAQMARAWSLLHQCSLEQWKLGHGEAAGFGLTVMCCNNVVFKDCSPAFCTSQQNIINIPKSHRIFRFRRRHKFTKMAEHFEYKVVPAQMSCIQNFQVKSVLCVQQNTVVLHLIRNMTTQFGIVDLSSDKFLGVFGVQNVGFINEDLRGKISPDCSVCLIKLPSLQTGVVNGYEFQLYDLKTKNLLGEYSLPYLDTAFAFDPRFNWTHFAATSFQVGSDNSLSIVRVKSWEVLVTNPRLDDQRPSQNNELKDIFYSREGHLIFAVTITEGCHCRERKSRRTNPCDISIFVFNADTADTIHCIRYHRFTCGLHLCPVNYMPLFSHCGSRMAIILNDMEDTLDHVQIYKLPSSMSLQYRCRVRILQQYGPDRLRQLPLPKRLVQFLKFFPEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJ08</accession>
    <name>A0ABY7FJ08_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_016164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR22190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="248" mass="27238" checksum="AD0D739C0CA5499A" modified="2025-10-08" version="1">MFVSGVALGAIAHPRPVRSVAADNPCNMVLAEDPMEPSDYISRLTDIQTRSEGIELDAQGIMTQLKESGKVNSFTATFLDEYNFMDTEGMTVSQDKISAAINNQVETLQSHFQFLLQYILHIQDIKGNYTVGTNTEAAKAELLSALDHLENKIQRTACSVVLALRAKGKYILTAMVVSGVALVAIAHPRPVRSVAADNPCNLVLTDDPVKPSDYSIRLADIQTRSEGIELDAQGIKTQRYRKSDRITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJA5</accession>
    <name>A0ABY7FJA5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_016244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR22270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="131" mass="14218" checksum="7A10CFEA620EBCFC" modified="2025-10-08" version="1">MGRTSYRCKVSASCVHSRQVRGRARARYPRTDGWIDIRFAASQLAAPEIDFLLSSGITDNFDGRDEGHICGVFHIVASVPSGKGCSVHHSVKPLVKGTCAILQGLLAEPTKHPVGEYVRDGLMQAKQAKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKN0</accession>
    <name>A0ABY7FKN0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="28" mass="3037" checksum="C76BB255856BC62C" modified="2025-10-08" version="1">MLVSIIAGFQGTTTYRSRLVASFTITTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMJ7</accession>
    <name>A0ABY7FMJ7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CML16-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_036949</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051581">
        <property type="entry name" value="Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524">
        <property type="entry name" value="CALCYPHOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524:SF6">
        <property type="entry name" value="CALCYPHOSINE LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="162"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="339"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="375"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="416"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR23280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="761" mass="86729" checksum="38767579BDAF7E7A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQ95</accession>
    <name>A0ABY7FQ95_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ACT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_037003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR23334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="369" mass="41104" checksum="995FF54A0C7421A4" modified="2025-10-08" version="1">MADDGDVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMYVAIQAVLSLYASGRTTGIVMDSGDGVSHTVPIYEGYALPHAIIRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMQTAASSSSLEKSYELPDGQVITIGNERFRCPEAMFQPSFIGMESAGIHETTYNSIMKCDVDIRKDLYANTVLSGGSTMFPGIADRMQKEISSLAPPTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQZ5</accession>
    <name>A0ABY7FQZ5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_038312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="238"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR24643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="750" mass="82740" checksum="D66B42788D5F9E62" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRI8</accession>
    <name>A0ABY7FRI8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_038314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000647">
        <property type="entry name" value="CTF/NFI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492">
        <property type="entry name" value="NUCLEAR FACTOR I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492:SF8">
        <property type="entry name" value="NUCLEAR FACTOR I, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="572"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="607" mass="64294" checksum="99936C494A751F8B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRR1</accession>
    <name>A0ABY7FRR1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_038582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="275" mass="31483" checksum="F72E82C7CA1FC76D" modified="2025-10-08" version="1">MHERWMRVHGSRHITSSSEEAVEKRQASISTRQCHCTTIRRTITVTVPLYNSTENNYCHGATVQPYGEPLLSPCHCRTIRRTITVKVPLYNHTENNYCHGATVQQYGEQLLSPCHCTTIQRTITVTVPLFNNTENNYCNCATVQQYGEQLLPRCHCTTIRRTITVTVPLYNNTENNYCHGATVQQYGEQLLSRCHCTPIQRTITCHCTTIRRIITVAVPLYSNTENNYCHSATVHQYGEKFLSQYHCITIRRTVSVTVPLYTNIDNNYCNSATVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTA9</accession>
    <name>A0ABY7FTA9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear protein MDM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_011169</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MDM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029136">
        <property type="entry name" value="MDM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32078">
        <property type="entry name" value="NUCLEAR PROTEIN MDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32078:SF1">
        <property type="entry name" value="NUCLEAR PROTEIN MDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15501">
        <property type="entry name" value="MDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="216"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="422"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR25465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="668" mass="74950" checksum="3CC4DDC626426101" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWX0</accession>
    <name>A0ABY7FWX0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_011088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR25384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="84" mass="9634" checksum="DBF4251723734574" modified="2025-10-08" version="1">MRFEACCLLEGIIMWTNNETSAWLADKTKADSEEIIEQARKDTATMHQAKSVDNTTEALVSKLQFRKANSEKIKKDFPETVKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYE8</accession>
    <name>A0ABY7FYE8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CILP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056255">
        <property type="entry name" value="CILP-1/2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23708">
        <property type="entry name" value="CILP_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cartilage intermediate layer protein 1/2" evidence="1">
        <location>
            <begin position="177"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="321" mass="35826" checksum="F50D681D3142BDA5" modified="2025-10-08" version="1" fragment="single">MEYGRECPPKKKFSGGLGNIYDDLFHSKHENEYVDLNIIDRRSSTDISCQNENKHYDNSLYIEKGTFFAGVQQRIHTKSTLRLFDQDRQQVYQPEAGHCGVTGHSAQLPVHQGSTSDTVNDSQLLDIALYPNATLLNIDNVHETHSGQYQCRANSPAGAIMSTAANIQIRESPDDFCADSLQQKAVALPSDCVQEATNTATFEVGECIAKSCRQNGSIDVQTCGEDSAGNPLTLGGEIEIKFPENTSPDILDKDFKLWSLNTDTGVWEVIIPSSQSSRRKKRQFASTDPVNEAKRCRLAWYPYRDIDDPYVKDGYKVCKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZW3</accession>
    <name>A0ABY7FZW3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ITPR1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_013414</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13715:SF99">
        <property type="entry name" value="INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13715">
        <property type="entry name" value="RYANODINE RECEPTOR AND IP3 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="8">
        <location>
            <begin position="29"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR27710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="248" mass="29429" checksum="84D354EE143D09F3" modified="2025-10-08" version="1">MDVVDRERPPLYHYLRVFNVHYPSWTGRSLLLVAVLGLAIFYIYSLVLFAFYGDRWLAENGRHCRTVYECFVSIVHHALVDSAYAQFEGNMSDDFKQAIGITFFDVSFFIIITTIGLNIIFGIIVDTFSQLRDSKGFIKHVKEEHYQWAYLFFFIHLDETRPNDYSALELFVYKLLTINNFEFFPLNRALSLENEEDTNEQRMEHLQQQIDYLVTKMKEQEADHLRAKEKQRQQEWEQTHKKNGNKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G070</accession>
    <name>A0ABY7G070_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="73" mass="8295" checksum="9AD3ED1B12127EB3" modified="2025-10-08" version="1">MYHKIQTALNCVPATFSDKLVVLNVNFSLLQNCQHVSKFTTIDLYTPVFEKKRISSLYIKAFGIIVYLASVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1F6</accession>
    <name>A0ABY7G1F6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="159" mass="18356" checksum="2DA7B4CB76426E83" modified="2025-10-08" version="1">MRSYITRVEVEKIGYRSGKRCQSDQTRSLHDCFSINSIFNSINTRSLPELFSTAWLHDRYTNFFDMSKKFGPSDADQGRPPRPLPINHADLPRQVPDRLIGLDRVDLIGSGSPAYVNANFCSMRKITFFTDSIRPIVEAMRKVKVTRLVFMSSWYTKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3C6</accession>
    <name>A0ABY7G3C6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LHPL4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_011500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489">
        <property type="entry name" value="LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489:SF1">
        <property type="entry name" value="LP10272P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR25796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="265" mass="29947" checksum="367FF5CC9D331011" modified="2025-10-08" version="1">MEQQYNPDTARIYHFRYMREYRAVCVLWAVLTIIWATFNVVVFVQPQWIGDSPESPGYGHHGVYKYCYPDNLALRYQCDGSFTDFNSILNDQYKATTFFVGVSALLMLISVAALLLFFCFKKTAVFILVGILELVTAIFMFLACVIYPAGWDNKQLMEICGESSGPYNMGKCNIRWAYILAILGIFDAAILAVLAFFLASKRAKIEMYSSSAELNGFGAETMSKRSMPIQPAVLAVPSVHHDPRESYSEYSQVQKRPGSQSNFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G527</accession>
    <name>A0ABY7G527_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="349" mass="39988" checksum="2C5CEFDE46F0145C" modified="2025-10-08" version="1">MCVGCMRNWQYNPVKCHSCKQPKINSPVGDRWGAILIAGTDKKPDVRKRFEDDIAKLKDKLITEVTVMGVREKNVITVTKSSTQYDEQLKKAFNQIDTSDINTLVLCYSGHHGDARFELDSENGKYLEDADLISNMNKLKHVEKIVLFLDCCFPKILDLSCEIVLQLNAVKVSEQASCESKGSQYINEIVDAVTNPCELECCNNTQIIREYDLHTHLSRYRDRHDHTQPSCQIVTGREIDRILAFRPVRSGWLNVLEKSLKSSKLQVLKTRLIKYILHAYSTIPLNPILQHKHSKLVDFYEPTKMTTTIEETEHKDSILDLSHYQLETLILDAINIKEVVTCSMETCTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G557</accession>
    <name>A0ABY7G557_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR29568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="240" mass="27378" checksum="97519002F2803114" modified="2025-10-08" version="1">MEEEASQYVGSVLTTNIAEKVDWTPAKHPDNPCCRKRSLSGANEDESEEQSKKIKTKTIQCDAITVESFDTNALLLQLSRDVKLVAETINHRIDMLEEKISDSEKRITEQVSNNITKVFDKRMSSEMSRMRKDMDNKIGDLLIRNLPFNEPEDIDRKLSDLLRNGLKIQDVNLVKVERKKALSDSTPGVVVAKCNSLEDKNHYTCNSYGEMLLEFLFDVNFAMLNGRDCLKDDITCVRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5P3</accession>
    <name>A0ABY7G5P3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BGH3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_014342</name>
        <name evidence="4" type="ORF">MAR_014343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045034281" evidence="1">
        <location>
            <begin position="17"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="15"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="144"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR28638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR28639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="283" mass="29988" checksum="D0606C9F8B099DF5" modified="2025-10-08" version="1">MIARLILVGLAACVYGETIPELATRLGATELVKLVTDAGLAGTLSGAGPFTVFGPTNAAFSKLPKNILERLMRDKKLLADVLKYHVVSGNVYSSQLSNELTAPSLLTMNGKALDIRFNIYNNGQNASNGVIHVVDRVMFPIPFEDIPTEVTKQSARFSTLLTAVKAANLVSTLAGGPFTLFAPTNAAFAKIPADVLNKLLANVTALTDVLTYHVVSGTYWSASLSNGMMPKTVEGKAVNIKIDGGKVMVNDATVEEADLAVTNGVIHVIDTVLLPPAFDPSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5P9</accession>
    <name>A0ABY7G5P9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGRB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_003323</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR29755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="363" mass="41058" checksum="D9315073CD99E9E3" modified="2025-10-08" version="1" fragment="single">MKSSYKSFDLFRTYLYQLNVYRMVWIRPSVVVLMIVIQTCSAGRLERMERRLEMKLKAFQAYVEVRLDATDGDFGTLADRVSKLEAIVSTSENDISEKRSNGSRNEHTKAYTKPEVNHIQNTLTMYKRSFEKQKQEMNDVKMVFKDALSVFLNNASLTVSTLFNAVNEHVNNSADDISATLKNVSDTVVKSGSHLRSDIFTYLGNLSSEVKTELALHVEGATDDNNKTLIALNSQVRDHIANETESLEVFKTKILQDVNEARALVQNETTELEKKVEELIGRAKEVVGIIDEQRSTIEDGIMVTNRALHSSWSDWSAWSDCSQSCDSGRKSRHRSCDVTPPTIDGICIGNATETEQCFIHEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5S2</accession>
    <name>A0ABY7G5S2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="232" mass="23845" checksum="FC6166A1E96B3CA5" modified="2025-10-08" version="1">MSNVIPPSALFLKDPVDWVAQTGCECSAAGIGYVHDVQKGPAVYTAGTGGALPGLTPEETAILAGILTGLATFLFLLLPILCCLCPLCAGCCGRKKAAAMHEGGWEGIDVSRDEIDAGASRGDGGMEIVERSGMVSHAAAGGGGGGGLGGEGGYSNAGYSSMDRGRGGGDEVITEYTTTRRVDMTIGAMSPEEAEGYYAQNYGGGGGQDGSMTRDNFMRIYHQYRNDLSNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G621</accession>
    <name>A0ABY7G621_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RFX7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF21">
        <property type="entry name" value="RFX-TYPE WINGED-HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="2">
        <location>
            <begin position="76"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR29595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="239" mass="27088" checksum="CDCABE37F5EC08D4" modified="2025-10-08" version="1">MASQHRVFAALLSQPANPIHPAISTTTVQQPNSVLEKKARDANVGKRYMKIHDGLESSIRTPPSCLPMSNRKEQGEAFTWIRTHFEEHTDVCMPKAQVYDEYKLFCEQHGLRALCNADFGKVMRQVFPDINTRRLGQRGQYFYGGLRKRQDFEEPSLPELEISNKHIELDSSVVEGEVFKSSCELVLEWAEKVLDMRFDSVPSVAEHLVGNMYVNTRSVAAFTLIGALQDSGKNNLKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6M9</accession>
    <name>A0ABY7G6M9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF9">
        <property type="entry name" value="ZINC FINGER PROTEIN 862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="108" mass="12486" checksum="C8835F5C08FD9322" modified="2025-10-08" version="1">MALQTSLTLKRREEGNAEWILPVWCMAHRLELAVKDCFKSTYMDNVIELLESIYYFYKGSAKRFKEAKDIADLLGENFLKPEKANGTRWVDHKLKAVSILSFLKIGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GD12</accession>
    <name>A0ABY7GD12_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="289" mass="33489" checksum="D64309299B9CBC6E" modified="2025-10-08" version="1">MTRELHKTVLGSIVRQMSAYTGPIQLYRTHNGIASSPYLEWRLDTFSLYPTFSCECLSYKLRRLQIQDADNNLKIDINKHAYNNAVWILATCIRSYMATYLTKQRVGNGHIATHGGKNNELVVSMFEITGKTCMVTPRVLKCRWTLVIKLTYTRFKAAFIEELSRPLMPRDIKVILWYHQGQWQLLEDLHYTIQKHQTYTSGLHTMDNIASLFTIIHPPALSGIPMLASSNKHSIHFREFQFCIALLWDQKKDSPILDFYYYTAHMYDILAPSSTIISPKISELFLTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GFB6</accession>
    <name>A0ABY7GFB6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAPD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="1">
        <location>
            <begin position="145"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="334" mass="37924" checksum="E093F53FF93F43DF" modified="2025-10-08" version="1" fragment="single">MALGPDLAQLSRHLRQERLYVTSEREQLQSLYEQVKTAAEQLYHQSWIGRQQKTFLDLLVSASQQVTPTECCAKTSQLEATNFIDSYKQLSYHDSKYGEFLKYILDNPVFIGTVIAIAEKSNVPNVADVIKTLVRSVFGNCILQEDETAMLHVLKSLLELQLSSSVDPRRLLRRGSCAFSVAFKQLFDMVFSAKLFLTAALHDPVMRLLMEDEWFYDIDPGKALVRFPPAERLRRFGEPGTDQYKEKLVKYRTTIVDKLVLMANRFITSIKNNMHCFPQSLGWIVSQVYQVLAKSGKAEMGEVRSVCADLVFALFICPAICDPEPHGITTDVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBE0</accession>
    <name>A0ABY7DBE0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GBP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_007467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1000.10">
        <property type="entry name" value="Guanylate-binding protein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003191">
        <property type="entry name" value="Guanylate-bd/ATL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02841">
        <property type="entry name" value="GBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GB1/RHD3-type G" evidence="7">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="506"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ94996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="535" mass="62508" checksum="F9CB345A7CE5CF2E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBK2</accession>
    <name>A0ABY7DBK2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">H17B6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_006754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ94283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="563" mass="63004" checksum="0FE337A3D27CE031" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DC64</accession>
    <name>A0ABY7DC64_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SCRN3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C69 family. Secernin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994:SF17">
        <property type="entry name" value="LD30995P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="SECERNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="419" mass="46331" checksum="B9208EF1D2EF6F77" modified="2025-10-08" version="1">MSDILVVLPPLTADGSVIFAKNSDRPPTEVQEVVYVPPASHDKGTKLHCTFIEVDQIPETRGVILSKPAWCWGAEMGANDHGVCIGNTAVWTRLCRPGDHEEKLIGMDLVRLGLERSSTAREAIDVISILLMTHGQGGICSEDHNFGQWTYHNSFVIADKQEAWLLETADKMWAAKKVTNGVLAVSNCLTIGTEADIMSPDILAQAQNGGYWKADDGELNFAKAFSADYPGISLSEKQTPGNRLNFVQNSLHSVKDKVDISHIFKLLRNEESSVNFIGELLTVGSQVSVLAPPTSSQPCCHWFTGTPNANVSIFKPFIFCDSPNIGTWTVSSTFSDTPRASFQTTIDRRHALYRAHEKGRELMETGSPVGAQMHATLRRLEAQCVREVMEFVKTYRESDMSEARDLFSDIAESEIKFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DC89</accession>
    <name>A0ABY7DC89_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ95287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="432" mass="48374" checksum="AEA4EEEEB2837E07" modified="2025-10-08" version="1" fragment="single">FILAPTCALIRPDGQSLEAFGYDAEDRYTELASEDKHRPWYFFKRFKMMLFDKMELHRGTEIEDVLGKKLTAKTAGILRCGLLIALEPESASIYCRHLPAEMCRGTSVSVTTFEPGTKYMVLDAGGKDVLKQFKEKHMENYVDLIRDFEIKKRDISTTGKSNFRLPSALLDLVKEITGKTIKETIVQSVYKESVSFIGDKLRVESKIAMKFFDVSIDSIIAHVSSLIQKPTVSGCSVIVMVGGFSESTLLQDRIRSKFSTMDVISPNEAGTVVLKGAVIFGHNPGAIAQRVLKITYGQEMTHVTKDECIHDHPEADRERDDNGQMRCLNLVDIHARAGQAVTEGQEQPEQVYTPVYDDQTELECSILTSDIGNPIYATDCQEIGKWSFPITDTSLGRKREFGVTFMFGGTEVVVKVVDKVSKAERKIHLDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDP9</accession>
    <name>A0ABY7DDP9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ95156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="99" mass="11773" checksum="4884926A7214A7D0" modified="2025-10-08" version="1">MEDRNHTYVEWKTETHTDVEWKTETHTDVELKTETQKTQSDVEWKTVTHSDVEWKTETQSDVEWKTETHITFNGRQKPTLTLIGRQKPTLTFNGSQKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DF86</accession>
    <name>A0ABY7DF86_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_028624</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the stanniocalcin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004978">
        <property type="entry name" value="Stanniocalcin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11245:SF6">
        <property type="entry name" value="DUF19 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11245">
        <property type="entry name" value="STANNIOCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03298">
        <property type="entry name" value="Stanniocalcin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0372">Hormone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ95934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="424" mass="47609" checksum="827D51E9AFFA6355" modified="2025-10-08" version="1" fragment="single">YLCDEICSFDGCDLCQYRHHCDSTCIGLCKTSDPCDPNPCFNNQTCEQKPQGSAHCVPGVDPKCMEKAQRGTCDFYQCFDEKTQCGAGGYALKFGTKYCNRFSYFYSNFTSGGQAMIDCVRHCLTRFLLNYYEMPNSDCSAIESAAFDSHVNCYVGCNFCDEWNDNKKALYNVYDMEHRAILLALFASILSSCYCQFDQARIDLPKGGRYVCPYCIYCGYQYICDGTCSYDGCDLCQYRHHCDSTCNGLCKTPADPCDPNPCPNNQTCEQKPQGSAHCVPGVDPKCMEKAQRGTCDFYQCFDEKTQCGAGGYALKFGATYCNRFGDYYSNFTSGGQKMIDCVRHCLTRFLLKYYEMPNGDCSAIESAAFDSHVNCYVSCNFCDVWNDNKKALYNVYELRDIALSPTIWSQMAEVGVTCLLPSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGE1</accession>
    <name>A0ABY7DGE1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHIT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_028199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="18"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="732"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="833"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ95509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1104" mass="124369" checksum="5E11EC9BA77E1635" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGN0</accession>
    <name>A0ABY7DGN0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_027923</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052603">
        <property type="entry name" value="EFCB6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875:SF0">
        <property type="entry name" value="GH12158P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="616"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ95233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="917" mass="105136" checksum="C693463B1B5ADB9F" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGQ3</accession>
    <name>A0ABY7DGQ3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G3BP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_029561</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="6">
        <location>
            <begin position="11"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="340"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="404"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ96871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="493" mass="54037" checksum="A28432146215F354" modified="2025-10-08" version="1">MVMETPSPQCVGREFVRQYYTLLHEAPLHLHRFYSHNSSFVHGGVEKPGEEQPPVIGQPEIHKKIMCLDFRDCHAKIRQVDSQATVGNAVVVQVTGELSNNGQPMRRFMQTFVLAPQSPKKYYVHNDIFRYQDEVFHDNDTDTEILEDAQDSEGEIVEPVDVGQTADLIADNQQFYEPHAQPLSNGTGLLEEEPVEMPPSPKSEPEEPLESKEPVQMEAFEPVKEEPKVEQPEEPQQIQEEPRQNKPFSWAAMASKNTMGAPAPVSQMPVQTQAPPKPAPGFGTRQDMKQDTSPTAPKEQRAPRGGRDRPDRGRDRDRMSMGREDGEVGDRRGTRYPDSHQLFVGNLPHNVSEKELKAFFEEYGSVVELRINTKSGSGKVPNFGFVVFESNDPVDSILKKSASGLAIKLHDHRLNVEEKKPRGGDRTMGRGPPPRSGSAGGMGGGGFNSRGGSAGRGMGPRGGSSGMREGGRGGGSGNMGPRGGGGGMSGPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHJ4</accession>
    <name>A0ABY7DHJ4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylguanine DNA methyltransferase ribonuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.70">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methylguanine DNA methyltransferase ribonuclease-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="117" mass="13266" checksum="486B15A8517F128A" modified="2025-10-08" version="1">MSIKCQYGPTNTYIVATPLGDYEVVCCPKGLHDLGMVGSVNDANFTPKPGIKVCLKSQQYEDNGYTYKPATDCVNWLEAYFSTKDKRDCNKHICPRNYNNTTIYNRFNNNCNVFANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DI16</accession>
    <name>A0ABY7DI16_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPN4A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_029035</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd14969">
        <property type="entry name" value="7tmA_Opsins_type2_animals"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="130"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAQ96345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="470" mass="52584" checksum="4EEBEDB16AF214A1" modified="2025-10-08" version="1" fragment="single">GAWDIPGIVASRHNQVIVELIAVCDVGAGAAGEELEEQQEANRGHDIGAHLRRPLENIEFGYHPYRKHIINDFLEYLLHAPAMLLNETGHPLDPYEGLTPLEIKRLEFPKWGHQIVGAFLMCVTIFGFIENSLVMFIFFRNKTLLSPTNIFILGVAFGDLGMACLGNPLAFTSALNGGWFAGEFFCYWEGFIVYFLGLSQMYLIMAVSVDRYIVIAKPLLSSKITKKVAVISMAVCFVVSLLWALMPFLGFSSYGLEAPGVFCGLHWEDQSFNNTSFIIAIFILCFFVPLGVMIYSYYHVFMTVRTVNKNMVWDMNSRMARKNLKLEKRMLKTCVIMCGVFFAVWTPYAVVSMIQAFGDPDSIPLFVMELPSAAAKSQMVWNPIIYVATNKKFRIAFYEALPCGSIRDRLIHREEENDSNMSNVGDKTAAASSYAQTKIINRTTNPTAAKAAKTNQVAPTPEPGPSKMEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIJ9</accession>
    <name>A0ABY7DIJ9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.80.10">
        <property type="entry name" value="Lipase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047430412" evidence="1">
        <location>
            <begin position="21"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="179" mass="19259" checksum="FB05835E760C9ADB" modified="2025-10-08" version="1">MAWYEMLFLLLGFVFISVQAVPAPGRGALKGYCITSEHCKKGECCISFNGKSVALSPDLRKFVDGKCEPLGSVGGSTCGERKCSKSNDCQKDECCVSKLQRKGKRSLDSAKQPGICKPMGTYNSDCLVSNGSGRPKGQVDLHCPCGNDLTCHGIGIRDFPLGELGKKALTEIFLSLRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIS6</accession>
    <name>A0ABY7DIS6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RAC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_029556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ96866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="139" mass="15725" checksum="A99ABDD0EA329EA9" modified="2025-10-08" version="1">MKSIKCVAVGDDLDEYKAVISVDDSDYEVNLFDTSGMEAYDRLRPFSYPMTWVPEVRHHCKDTPIILVGTKVDAREFSDRSEIVKNQQGRRLKKLVGARYYVECSAQTKMGIVEVFQDAVRAAIAPPVKQHGNGRCKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIW5</accession>
    <name>A0ABY7DIW5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GRB2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_030252</name>
        <name evidence="8" type="ORF">MAR_030324</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd09941">
        <property type="entry name" value="SH2_Grb2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11804">
        <property type="entry name" value="SH3_GRB2_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043539">
        <property type="entry name" value="Grb2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46037">
        <property type="entry name" value="PROTEIN ENHANCER OF SEVENLESS 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="60"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="108"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="194"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ97562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ97634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="264" mass="30283" checksum="9B8E4277553325E2" modified="2025-10-08" version="1">MEATAKHEFNATADDELSFAKGDVLKILSREDDQNWYKAEFNGREGYIPNNYIDLKPHDWFYGRMKRNEAEELLLQKNHNGQFIHPDGAFLVRNSESAPGDFSMSVKWFKGNIKRQDAESFLLEKSGGKFAHPDGAFLVRGCESQPGEFSLSVKFQDGVQHFKILRDGAGKYFLWVVKFNSINELIEYHRRASVSRGQSITLRDMKNLAAQEPGEVYLKKGDEVLVEDEVDKHWWKGTNARTKEAGLFPANYIKLIYPTVLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJE8</accession>
    <name>A0ABY7DJE8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AAAP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ97323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="320" mass="35447" checksum="AC17ABCFF6B04A6A" modified="2025-10-08" version="1">MEGVSANLWAVVYAEWRAVVSPERKVVVSAEWRAVVSAELWAVVSAERKAVVSAELWAVVSAERKEVVSAEWRAVVSSKRKAEVSAEWRAVLSAEWRAVVSPERKAVVSAEWRAVVSAEWRAYPHEWRAVVSAEWRAVGVSAEWRAVVSAEWRAVVSAEWRTVVSAELRAVVSAEWRAVGVSAEWRAVVSAEWRVVVSAELAVVSAEWRAVVSAEWRAVVSAEWRAVVSAEWRAVVSAELAVVSAEWRAVVSAEWRAVVSAEWRAVVSAEWRAVVSAELWAVGVSAEWRAVVSAEWRAVVSAEWRAVVSAEWRAVEVSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJM5</accession>
    <name>A0ABY7DJM5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MATN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_030088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046644047" evidence="1">
        <location>
            <begin position="25"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="126"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="294"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="494" mass="54860" checksum="F4EC268B301E78B6" modified="2025-10-08" version="1">MRKMYLRFFVLACISSHSLLDVCAQGCFARCEWSEWESWTTCSQTCGSTEKKNTSRGLCCPSDLTDLESCVEYCNLDIADHYDEADCGRECYNDGTLSSAGCVCTNRFYGMCCDKRLDICEAIPTDVVFILDSSLSQTQTEFQKQLDFVGKFVDNVDVGPTAFVLSIITYSSTAVVEIEFDDSNSKQSIKEQLLGIQFRPGATYTNKGLELARSLLSVRMERRPGMYTKKIAFVLTDGVGPEVSHRELNAIASPADDYSLSYVYTVESFDALHTVLERLIDVSCEKCQPKSLTDIFLLVDDLPDSRMTVTEWQIAVNGLATIVDGLQAFNDENGQRVGIAQFPDTNDPIKQLSLSNTLRKDDILHFLQVMAHSEDTCRGTKDDCVLKSNITSIIQNVIDNQFTSSFGGRDDARKVLLVVSSGRFSNITEVAEQMRNIRLHTDVDIFDIGPGGDVDMRGLKSLVSEPSRVFVVKEDSDMASLDGLQAKFSYIACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DK87</accession>
    <name>A0ABY7DK87_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IF2P-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_022137</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor Tu-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ97764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="168" mass="18849" checksum="ECADC11F12CC7D31" modified="2025-10-08" version="1">MGVSVEAGILKPGTPICVPSKEFVFLGQVSSIEINNKPVDSARRGQEVCIKIENVPGDTPKLFGRHFDDTDMLMSRISRDSIDAVKNYFRDDMTKQDWGLMVELKKLFQILMRAGFGLEDSCHGQTLLTRLTLVPDQIETYPDSIIIELKQMVTNIDGLYTLVNSLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKE2</accession>
    <name>A0ABY7DKE2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_022525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ98152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="954" mass="105296" checksum="53E1A5EF9149E89E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKM9</accession>
    <name>A0ABY7DKM9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_022639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd10229">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ98266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="545" mass="61842" checksum="AF3D54DAF8EC5205" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMA1</accession>
    <name>A0ABY7DMA1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028001">
        <property type="entry name" value="SAXO5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34828">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34828:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15373">
        <property type="entry name" value="SAXO5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="431" mass="49482" checksum="E3AE4CDC392A7760" modified="2025-10-08" version="1">MSAAEVVAPIIKQKTGQDFLESTSFRIGQDDQLTNQRMDSIFKSDYPPYGTYGRPAGARPPPLSEVMHRDQKFFSERESETTKSFEYRHLPKPEIQGASGKLRVTNFKMDRDISKFNNFETVHNSYFTPKMGDAYKRVEGAGTRQSNIPQGDREKEPQPLTDYRDIYNVPTGDPRNVVERETTMNASFQDMSNQNQRQPYNTEHVSKVLNQTNFKQQDGHYKWNDYRSTATSSYMPSVIPVERFKPGKHRNHSDFPEGDLDNQRVNERVNLTTNRFYHGNPPRGLHNTIISGANLRTRSNVWFGEPLLGSSFYNTTNSRSFSAKTVPYTYNRQSFYKESDIPVNYYGKGERNHTTAFSDYKDPRKVKTAPNSQAIENLKMSHILPPISNLRNFNTTHNDTFYPKSSERYSYDAGRLQKSSVPLGTMAGVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DND9</accession>
    <name>A0ABY7DND9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IKBA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_022766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ98393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="348" mass="39226" checksum="37D63FD725056DE1" modified="2025-10-08" version="1">MDFEYMDSYGISRRYVQNLAQMAKDAIITLLKDTGTCLSKSHYFNQICRQLQQYGTEHTTVKRQKVNIVQNHQYKGHIQTNKQEELIPRLVVATAADSLAEKALIANVIVTTDRDGDNLLFVAIIMRKTKLAMNLINLTTDYSQVRSVNKLRQTALHLAAITNNPIVSRRLVVAGAEIEMQDYNGNTALHIACIQGWAGVVRSLIQHVSYEETKQNSFKIPYVPIPQNFEIRNYDGSPCLMIAICKGYLDIADMLIDIDADINTFDMKTGMTCVHAVTELGLIHLVRYLLSKPNLKINAETYSGYTAMEIAFYRGYADVAALLKVSGANRPRPICIIENLDLEEDRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DP83</accession>
    <name>A0ABY7DP83_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="334" mass="39299" checksum="3BB085F102082E44" modified="2025-10-08" version="1">MDEIHRELLMKRQKYLRDNIIMEERLLRRLKDCGVFSNSMIQTIQEYPWVVDNFREKEQDLMEHARANSDVNPDIRQTVKEYVRELARTTRMNNAQRKNVEDFLCRQITIDTNLNNGSMPGKKLYSIHKLLMQAMHVTSLNENEQMDVNNILPDNVTIDKIETEVMHMVNRVQDLETVIDTCYEKLGETNKEKELPDLVWTQQKQLLEKEIQIEELKAKVTTQHKTMRLAREKEKRAREESVKNSKDKEDVERSLDILKAKIHKMQEERQRIGMRMAFDSGNAIVASTSTAATSAEASTMQDPSHSEQKPPKVRMEEKTKHVHVDDKTSRLWEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRH1</accession>
    <name>A0ABY7DRH1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MAR_023308</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">MELC-2E11</strain>
            <tissue evidence="18">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SH3RF family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd16750">
        <property type="entry name" value="RING-HC_SH3RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11786">
        <property type="entry name" value="SH3_SH3RF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11785">
        <property type="entry name" value="SH3_SH3RF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035816">
        <property type="entry name" value="SH3RF1/SH3RF3_SH3_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028502">
        <property type="entry name" value="SH3RF3_RING-HC_Zfn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF51">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="81"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="190"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="715"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="294"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="391"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="443"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="488"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WAQ98935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="775" mass="83317" checksum="72285927EBF9EB47" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRR5</accession>
    <name>A0ABY7DRR5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F219A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_024765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM219 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029339">
        <property type="entry name" value="FAM219"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31281">
        <property type="entry name" value="PROTEIN FAM219A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31281:SF3">
        <property type="entry name" value="PROTEIN FAM219A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15260">
        <property type="entry name" value="FAM219A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR00393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="182" mass="20312" checksum="528EBE904D01D11C" modified="2025-10-08" version="1">MDTMDDSGIDSDNKTGPNDNFSTENNVDGNQSSKIPNGSDNGINAPKSINTSSELQKKIEKQREKNRRKGVVDDQPKKSFLLPRSRLNIPSKLLSSSLTQKEQEQPLVSLLSDDSEEDEFAVGAPLSREAQREITAQLIKDGYNLDLEPDDEDLDLIPPRPLHERWSCCPAATWVPHRCALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DST2</accession>
    <name>A0ABY7DST2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027932">
        <property type="entry name" value="DUF4606"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35256">
        <property type="entry name" value="CHROMOSOME 8 OPEN READING FRAME 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35256:SF1">
        <property type="entry name" value="EXPRESSED SEQUENCE AI429214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15379">
        <property type="entry name" value="DUF4606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="455" mass="52363" checksum="EA50FEB8FCF45A95" modified="2025-10-08" version="1">MTSTRKSSVTWKIPSIHRSQISPRTHRKDVETPSDLYEYSNTFEESSHEGQPDYSNTFVEDSYSDTFISGSSQSLSKSHSESRKGNYSHGSSLTGQIKHYSNAFSSGIKPKKDYSVSFEDSDTSIQEVTHLETAKNVTDVLETVHEVESRTEDFEHSTDSDQEISDTHPPETYTDTFESDERTMADTPYDTTETSDVQKTSYSETYFQSLVESTYSEEDSLLDHSFIAPDRNCKSLTDEEDETDVEDSYKEDFSYSYTFEPTETVTSHAQTRQSQLSIEEEQETEFVKRKFMRKMVEKMKQKSDTFKKMETLPAEHERGKVAKEEPVEAQVVTKDTMLADYGIPESVMERLRIKNIISAMEKAANEPIHEPRKCPQCSYRKTDLDTEDAERKFVTAQTMRLKNKIMDNRVEEHIIKMNTVSLVAELARDLPRHSEKPEKILDKLLEPLLGKNVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSY2</accession>
    <name>A0ABY7DSY2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CHIC2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_025185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039735">
        <property type="entry name" value="CHIC1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13005">
        <property type="entry name" value="CYSTEINE-RICH HYDROPHOBIC DOMAIN PROTEIN BRAIN X-LINKED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13005:SF4">
        <property type="entry name" value="CYSTEINE-RICH HYDROPHOBIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="4">
        <location>
            <begin position="44"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR00813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="144" mass="16364" checksum="BB71B42BB070C21E" modified="2025-10-08" version="1">MADFDTIYEENDEESNNSAEYVLPVPDPIIIRGAGNITLFGLSNRFNAEFPTHLNGKVAPEEFRETVLRINSTLKKALPVNVKWLLCGCICCCCTLGCSLWPVVCLNKRTRHSMEKVLDWENSHLYHKVLVVEFIPKVSILRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DU21</accession>
    <name>A0ABY7DU21_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PXYP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_025317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046998266" evidence="2">
        <location>
            <begin position="23"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR00945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="443" mass="50124" checksum="695E4198F3298D5F" modified="2025-10-08" version="1">MGLKNLLRILIILFEGWLEIYGTNVNQFNMEASYCNMGENITGKEGAALPGYSLLQAHVFMSPGLTDMRGHFGKQGQRLPPLLCDLDPSSHNVLSWIQEQLKISIRAHVQHGRSHPEFQKYIPNFNLNCSTQDLSMVGFEQLAGIGQHLRRAYLDRIAHKALKAWHSSVYLESVISRPAFHSVLGLVQGLLPMQQTHKLKIRTATYNFCNTHEMNLSTCVCEELFQTAPFISQALNTGRYAFKHSSPDKGAIESFYNISLQTEVSTLQLVKLILQYKCANVSVNCDSSICSIFKENNIGVVLNLAKQHTERFLENPIYPNVAKLSTYPYLQRMVSRASRIQNQSMFVTMGNQHFLHYLVTSLGVHSHSILPLASRLVIEIYKKNDGKLLGSPLFFKVLMNGKDVTPDIPECLPHHRQTSLCSLHILVSMVTHTREHYLARCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUN6</accession>
    <name>A0ABY7DUN6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TAF1C-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_024712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038801">
        <property type="entry name" value="TAF1C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049087">
        <property type="entry name" value="TAF1C_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15319">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15319:SF1">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20641">
        <property type="entry name" value="TAF1C_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TAF1C beta-propeller" evidence="2">
        <location>
            <begin position="122"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR00340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="900" mass="100617" checksum="57D5837ECE646CEF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DV70</accession>
    <name>A0ABY7DV70_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FA81B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_024583</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM81 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029619">
        <property type="entry name" value="FAM81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22420">
        <property type="entry name" value="PROTEIN FAM81A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22420:SF4">
        <property type="entry name" value="PROTEIN FAM81A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="339"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR00211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="458" mass="53098" checksum="4D0685C367FA0AA4" modified="2025-10-08" version="1">MSYKTSSSQVFPHIPQQPQNNQQVRTRMKQDFTAIQVGDPHADQDRDSPTVHVRQTPPHRRSQPVDRDNGTQSKLDALVSRQDQLLQHQEQVSHRQNEIADHLRNQNQKMNEALIKQVLANKEDMIARFNQQQADDWDSSSRDLLQQHIKYMVAIIRRLNTDIEGLEAELRGRDIAVIGTNAAVNKLEVHHVTMLHDLRGRIVRCDTSIAKHTKDIIMVMEELRRLEGLIFGTREKLTADIHRLEAEVMSMTSELERQNGEQRSEMNHMKSDTAHRITMLEDRQKARMAEIHEAIDGNRDNIDHYLEKMDAKFKAMIDKATAGWGDMMSRVDARTDQNMMSILSRLKRLEEQMTRDKQNMKTVQQNIEGQVIATIQDSLEYQNAELAKAKNEFRNGFTELQDSLANMKRVVEGRRKLMGHQVNKELGMVKKALFMEMPPQEQPGTTFVVKNIDRSMEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVN5</accession>
    <name>A0ABY7DVN5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="75" mass="8754" checksum="95CF46A68A4962D2" modified="2025-10-08" version="1">MSQKHYPTHLRTKPKSQKPNPTHLTAMPMSQKRYPTHLIAKPISQKLDHTHLTAMLMSQKHYPTHLRAMPMSQKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXQ2</accession>
    <name>A0ABY7DXQ2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FBX31-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_008222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045048">
        <property type="entry name" value="FBXO31/39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706">
        <property type="entry name" value="F-BOX FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706:SF130">
        <property type="entry name" value="F-BOX ONLY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12014">
        <property type="entry name" value="Cyclin_D1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR01664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="261" mass="29944" checksum="518003927BF85994" modified="2025-10-08" version="1">MLKAGRVHLEKFIRRYEKGRIVAYEYFGKKDIRDNLERIRLFSISFVDGNVNVTWYRRHLDVDVTCTIEKVPVKMSMGTVFMYNSVILHTQIGVRLKRSKQVFERLRMPAITGTFGSQFPIGPGLFKGMYSALLLLTYDMEKQKALASKISGDSNVPAGEVSIEVNLQKPMVLTAEQQQSHASIRALNPDDPPPILGEDCDTFRQPYHALGTVSPTGYTDPQQIPVHFMVFNEEMFGVMWIGLHHFSLYVKVKEQFETYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXU4</accession>
    <name>A0ABY7DXU4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_009111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046565705" description="Kazal-like domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="2">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR02553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="209" mass="22664" checksum="FCE7D25BE4E3AE5C" modified="2025-10-08" version="1">MYLDKHLHTVNTRMRLVKLVLFSVVIGLTTAGKEEEVNAALDHVNGTYQHHLCDEIKKLHCDHLAHHIEVHVDGAVCEFAKSRCYYILNHNNYYAHSHIQIVSLNVHNLGPCPARTTAPPTPTIVAASTQAASMVGQNLSSSPPTTTVSATALMMAVFCLNKATIPCNSGHIQLTCGSDGRLYPNPCELLKEQCNTPNLATSPLSVCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYN9</accession>
    <name>A0ABY7DYN9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CBPC2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_009396</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd06907">
        <property type="entry name" value="M14_AGBL2-3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040626">
        <property type="entry name" value="Pepdidase_M14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF45">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE NNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18027">
        <property type="entry name" value="Pepdidase_M14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M14" evidence="5">
        <location>
            <begin position="435"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="654"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="729"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="819"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="963"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1056"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1120"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="664"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="753"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="819"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="847"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="869"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="977"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="990"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1000"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1067"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1144"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1156"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR02838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1215" mass="138945" checksum="833DEE622E722193" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0M6</accession>
    <name>A0ABY7E0M6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PGP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF93">
        <property type="entry name" value="FI11325P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="264" mass="29473" checksum="3C2A3050E1FCD5BC" modified="2025-10-08" version="1">MSRITHHVNKKLAREIVQKYENFLFDCDGVLYHGNEAIPGCAKALQKLKQLGKRVFYVTNNSSKTRAQMVEKCQSMGYPAEPDSIICTAHTAALYLKRMNFEGKVYMVGNPSMEAECDALGIKHEGSGINCVLVGFDPHLSYVKMIKASTYARNPNNLFLATNEDYFLPHKGDVVIPGTGSIVAAIKIPTRREPHVLGKPGTAMFDLLHEIHGLDADKCVMGLTIFSVLKPTSSQMIPTNGRLFPISIWRVSETWRNTYKTCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0U0</accession>
    <name>A0ABY7E0U0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SRSF7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_009362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd12373">
        <property type="entry name" value="RRM_SRSF3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="10"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR02804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="199" mass="22107" checksum="8C5A0F2FBB4DF8AC" modified="2025-10-08" version="1">MSRGGRDLDCKIYVGDLARDTNEKDIERAFSYYGRLRSVWVARNPAGFAFVEYEDPRDADDAVRGLDGTSINGVRVRVENSTGKVRPKPWLRGGGGGGGGRSGGRPGGGRRPFHPDDRCYECGESGHYAYDCPRYKSRGRRHSRPSNDISYDQLEMTTVSTSSLSDKHPCDSIFTSCRSPLTPNRTQNDNKRVLIIRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E155</accession>
    <name>A0ABY7E155_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_010098</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendritic spine</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037769">
        <property type="entry name" value="Abr/Bcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23182">
        <property type="entry name" value="BREAKPOINT CLUSTER REGION PROTEIN BCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23182:SF1">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 1A, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="7">
        <location>
            <begin position="778"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="1121"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="1196"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="450"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="544"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="641"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="565"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR03540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1402" mass="158757" checksum="42C869DFCAF622BE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1J0</accession>
    <name>A0ABY7E1J0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BIRA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_010248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="7"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR03690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="412" mass="45832" checksum="60395A1647FF907A" modified="2025-10-08" version="1" fragment="single">MSLFNVEAVRSRLTSGQIGRDVIYKQVTTTTMDDAEKGARKGKGHGVAYVADTMTNARGSKGRSWHAESGGNIYVSFIIHRDAQQGVNIPERHLENDIEIAASLAALHVLQERGVSNVKVKWLNDLWVRGHKLLGALAEFKGNLEVEGVRKHLYILGLGLNLNSNMRHQSGLQGLATSVWCETGHRMLREDVFIEVCRQLEVNLAKPREELLTLYQQNSVLCEGTEVKVYFTDQSKPTQVCTYLGVDKNWAVRLKNGLPEDCALLVIGQLQAPIDYSLFERVRGHVEEGISCWLIGSACSLCTQPGSDDFLDDKQHSVIIRSSVEKIDFDCTKNIDLPLRDDEDQSKGDTFVAMATFNIGRGIVCLCVPHIEVAYPDVGQHFPSLEGAHTLIEDTVYQRDSLIIHALEHLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1N0</accession>
    <name>A0ABY7E1N0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_025448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR01076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR01076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="610" mass="70198" checksum="04F775F482C2D5BD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E354</accession>
    <name>A0ABY7E354_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PRD14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_010197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF19">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="108"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="264"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR03639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="414" mass="47366" checksum="499A51DA38F2BBE6" modified="2025-10-08" version="1" fragment="single">MMPMNQLQMMYPPARPQFAGEMFPFKALSDLSNRLFPGAALREPRMPRAFYFRQEDLDNVLYGYSRLPGGTRAGIDRILSHGPNSPSPYMVSPYKYSRTEPPPHELPPELCICPTTFAGLVHYGVFCRKQTIEKGTRYGPFKGKVVNTSEIKSFDDNTFMWEIFKEGKLSHFIDGRGATGNWMSYVNCARHVSEQNVTVVQDGTQIYYELCRDVPVGTELLVWYGDAYLQFMGIPVTLSSADGQAADPAALEEDAKELSGGEGFKCERCGKVFAYRYYRDKHLKSFEKRDRLRIHILHVHEKHRPHKCSVCAKSFSQSSSLNKHMRVHSGERPYKCVYCNKSFTASSILRTHIRQHSGERPFKCKYCGKAFASHAAHDSHVRRTHPQEKATTCKECGQQFGHLFDLKLHMRVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3M7</accession>
    <name>A0ABY7E3M7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase</fullName>
            <ecNumber evidence="3">3.2.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_010377</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16301"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="EC" id="3.2.2.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16302"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARM1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.6" evidence="3"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039184">
        <property type="entry name" value="SARM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998:SF1">
        <property type="entry name" value="NAD(+) HYDROLASE SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998">
        <property type="entry name" value="SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="519"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="589"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="12">
        <location>
            <begin position="675"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR03819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="877" mass="98857" checksum="60C54D0087EA44FA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4M2</accession>
    <name>A0ABY7E4M2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">26S proteasome non-ATPase regulatory subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">26S proteasome regulatory subunit p27</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_019508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="6">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="115"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR04139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="202" mass="22137" checksum="9D1561DA58D8B40E" modified="2025-10-08" version="1">METQVIAIAKRLVRNMGWSSMDPGSPGVLQFPDTQKSIGMDGPLIDTEGFPRADIDIYSNDYKDIMDEIEEELYRIHAEARQSAGDKNSSQSAESLVSQASRDAEARSRLQPIGTVTNIDAGSPADTAGLKVGDVVIRFGSLTSENFQGLQNIANIVQHSMDKPIQLTVFRDSEDTQISLTPKRWKPDKGLLGCNIKPVTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4W8</accession>
    <name>A0ABY7E4W8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NCAM1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_020444</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="662"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="87"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="261"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="346"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="554"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR05075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="786" mass="86041" checksum="E1EF36AF96219D17" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E514</accession>
    <name>A0ABY7E514_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">DYH10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MAR_010451</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF63">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2014"/>
            <end position="2150"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2293"/>
            <end position="2411"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2621"/>
            <end position="2803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="64"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="847"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="988"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1389"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3212"/>
            <end position="3239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3426"/>
            <end position="3481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="851"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAR03893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="4626" mass="531941" checksum="1B689FE398E8D8AF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7X6</accession>
    <name>A0ABY7E7X6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GATA zinc finger domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_019888</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039050">
        <property type="entry name" value="GATAD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13340">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13340:SF2">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR04519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="283" mass="31701" checksum="DCDFE3B52F239DEE" modified="2025-10-08" version="1">MPLGVKPVCAGCKSSTSTMWSKNEKGDITCNECLTKPTPGVGKETNGNGVIQVKKVSSAVESAQDRVLRKSSRNKPSKYRVANSKPIATKGKSRRIIFKKSQPVKAPTAVSTVVTGNSIFHDGVYYQIGDIVSLVDEDENLYYAQIRGFLQDQYYEKSAVITWLLPTKISDRSKFDPATYILGPEEDLPRKMEYLEFVCHAPSEYFQSKTMPYPTINSKPDLCYIWSTLGPEVTEAPTDIDDIYGPSDYVKSDSPMQVFPQSNKRAKIEKVKIKEEKKFIVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBS9</accession>
    <name>A0ABY7EBS9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="168" mass="19508" checksum="261C0CCA6EDC7067" modified="2025-10-08" version="1">MQSKLQRRRHLNGIMIVSQNSHEDPHHVLACILHCVIFALPSMYKVRHKLVHGRKFKKDLKHEMYVLYLISAVLLIVEASGIFGPCPIYDFLTTNENDKVLSIVKICIAECSVCMATAYHIFKILCDDSPTWYRDDKCKTCFSECIQHVGWVLVKFGIRWVMRDIRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECC5</accession>
    <name>A0ABY7ECC5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_016782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="156" mass="17046" checksum="C61BF4CC0A821E18" modified="2025-10-08" version="1">MNTIVITQQPAGRQMLIGTVHGHRDWDSGICGCFSYCKSLIMTYCCLACAICNISIRAGECMFYALVCARGSNCTQGPNQDAWRYRGAHLLRLYGNKCNARLFQGSICGDSMAIHVMSVCFKIPSAGSICGDCMAMSCVPLCAICQMQRELEAMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECU5</accession>
    <name>A0ABY7ECU5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="127" mass="14321" checksum="816EAC5DF7522D0D" modified="2025-10-08" version="1">MAQSWEDSWHCKIDIIIGEVQAFLPADNSDDDGESFTLDNEAKTGGSFNEGEFWQILAETITYSFLKNNENKDVTLISSIAISKNSFKCFFYDSEEDVLLQSGGADGIACRGQWWQHCKIFQSLQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECV5</accession>
    <name>A0ABY7ECV5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ACKMT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_021910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANT/ATPSC lysine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026170">
        <property type="entry name" value="FAM173A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610:SF9">
        <property type="entry name" value="FI06469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR06541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="245" mass="27863" checksum="6741CC580A0337CA" modified="2025-10-08" version="1">MANKTNIIKELSAEECNICKIINEAPKQPKRPWDKKRIAVVGIFSSIAVGSVALTVPFIAPAFRRVCIPYVPATTTQVENVMAALKGRSGSLLDIGSGDGRVVIEASKHGFQGYGVELNRWLVLWSQYSSWRQGVNRSTRFFKQDLWKTDMSKYDNIVVFGVDTLMDGLEKKFEQEIKPESRVLVSRFPLPNWSPVSQTGSGLDAVWVYMRPDNPGYDQRKISKDTVKKNYEQERYEFDIFSKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDE0</accession>
    <name>A0ABY7EDE0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRI33-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF229">
        <property type="entry name" value="TRANSCRIPTION INTERMEDIARY FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="134"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="284" mass="32092" checksum="D3D8D94FCD801E1A" modified="2025-10-08" version="1">MASKHSTSLKHSVLNASDEIHDFSCSVCKDDNLNIEAKHFCGDCSKYYCDKCLPFHAKIHKRHVVLGKKDVDKWVGQGDTLVMCNLHPPKVLELQCEDHNELCCHLCVSLNHRMCRSISLISDLARGIHKKADFKQLQANVTKVTNTLNQVTEARKKNQNSLKASGKSMLTKIKTLRSSLNQLLDELEKKTVEQMDSVLADLDGSLQKDIDHCDLLHDQLKALLDYVQIQGKDSESSSYIGHRKCQEKMDEANKVLHDMSPKPEETVTFKPNTHVVMGDEIKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDV8</accession>
    <name>A0ABY7EDV8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">NRX4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_021958</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the neurexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF49">
        <property type="entry name" value="AXOTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045622719" evidence="11">
        <location>
            <begin position="24"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1216"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="12">
        <location>
            <begin position="35"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="13">
        <location>
            <begin position="188"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="13">
        <location>
            <begin position="369"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="527"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="13">
        <location>
            <begin position="778"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="950"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="13">
        <location>
            <begin position="990"/>
            <end position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR06589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1281" mass="144280" checksum="D64A78A0DFEC40E6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EET3</accession>
    <name>A0ABY7EET3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="249" mass="27732" checksum="E1B5AB137EA4E4C6" modified="2025-10-08" version="1">MKAVTGVGPDQKLPVDVVFGGSTLLRHQNKEMSQLHYVTGLILDHGGATDEVIVPVTYSRLSVLDVISTHRLPEAPPQSLYTTPRVEAVTVMSSCRISTAVNSLQLPHVTARSMGLASMTSAQLYCQAENPGPATRDMSMPYDIIGDNYDFTVNPNEMTKEKKQRKCLHWFLYCAVTKRVFSENLPDNGSTMDIKRAPCSVFVPGNSDIESLVSDFVFIIIDVVTNYLKFLKPYKSLVHFVLPMKTWML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGN1</accession>
    <name>A0ABY7EGN1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="261" mass="27752" checksum="2F6AEE4D714F30AD" modified="2025-10-08" version="1">MDNLTAMVNITAMDKQTAMVNITVMDNLNAIVNITAMEKPDCSGKHICHGQLTAMGNITAMDNLTAIVNITAMEKMTEVVNKTAMDNLTAIVNKTTIVNLTAMVSITALDDLTAAINLTAMDNLTAEVNITAMYNLTAVVNITAMDNLATMVNKQHGHPSCNVNITAIDNLNAMVPMMAGYGQPGMQPMMQPGMAPMGGMQMMGMAPMSGGVPMTTMPQMMGMGQPMYMGMRPGMAPMGMPMAQPRPPITQTQPNDPFGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EK44</accession>
    <name>A0ABY7EK44_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">FZD5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_034600</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd15035">
        <property type="entry name" value="7tmF_FZD5_FZD8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF126">
        <property type="entry name" value="FRIZZLED-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="488"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="12">
        <location>
            <begin position="102"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="13">
        <location>
            <begin position="322"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="207"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="115"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR09524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="657" mass="73653" checksum="5C28712323D5C425" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKU2</accession>
    <name>A0ABY7EKU2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_034673</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="300"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR09597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="370" mass="43138" checksum="8BF53827B49A983D" modified="2025-10-08" version="1">MTAFLNRNYFCDQCKKGYQHKERHSCNNPYNLCRRCIQTAEEWNIVIHDCFMQHMKKTEDGISTCDTFFRCKQCSQLINLSKHKRPRVRRNLMQNMVISVSCNLSKMLMKSSKSTIEKTLETKYIFLVLNAPKINALNVKMVINQEPRLSVRIAGNLVHNVCGECIAINITPSSKCFKCGTNERFFAGPNTTYLFCKWLFSEENESHGYNSYPILRYLHTNAVLPEIQSELVLLMDIELKQKQSLMAYKWLSYLDLTKWMYTTELHKEKRLFLEFHGVFGMVAQGVIQGHRPNRSFQTVRKGHQRYENQYYDVTSLYPFINKTANIPMGHPKIITENLKEIGQYEGLVKCKVLPPKGPNMPVLPMKCTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPR6</accession>
    <name>A0ABY7EPR6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FUCL7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_036321</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fucolectin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051941">
        <property type="entry name" value="BG_Antigen-Binding_Lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713:SF6">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713">
        <property type="entry name" value="FTP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR11245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="189" mass="20548" checksum="E99EE9EF0870AD80" modified="2025-10-08" version="1" fragment="single">ARNVALGKPAYQTDTFSQDTTADKAVDGNTSGNLLYDKSCTHTLSSDATWSVDLGAIYQVSTVTIYNRNAVRLRNVEVFIGLDKDGPYSLAGFHEGVVGASYTFTMPPNSQARYVNITRNPPYQRLTLCEVEVESPSSKFATSSMAKIQNSTPLATISNVRSPIGCAYACHMDLKCLKIGGQFQEQTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQI3</accession>
    <name>A0ABY7EQI3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="337" mass="38035" checksum="20287D85FA8EF083" modified="2025-10-08" version="1" fragment="single">MASAKPSNSWFSRVFRKNAKAQETTEKENHLIIAAIDFGTTFSGYAFSATQSLEEPIYCSLFEAEGYQTEKAPTSVLLNADKEICSFGYEAEKEYEEKMESNEGDGYYFFVRFKMNLYKTEKLSRETKLKDIRGKEMKAIEVFAKAGIEDKDLKLALEPESASLYCNLQSSCKIVKADNTATLESFPVGHRYIVADLGGGTADMAVHEILENNCLKEIARSDGDACGGAMVNLAFFEFLTKLLGGQVVNHILQTQTNVFIEIDRCFEIKKRAFKGDMKPVQMQFPIAEIKEAFEACETTFEDAKRKIKNDYDNKVEILRNGRLVFSAEIMEGFFKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ER51</accession>
    <name>A0ABY7ER51_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="100" mass="10936" checksum="F761832F644E441A" modified="2025-10-08" version="1">MHESCDESEDESSSMPTPDVADQASCSQPVTVAVIFDEAKGSPVSGHLACLTNNIIDKKMQDKKRSDLADKNPVAENVTKLNPPQVNPEIWRIIEAKTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ES84</accession>
    <name>A0ABY7ES84_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAMH1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="78" mass="9261" checksum="96AAFCCC65861D45" modified="2025-10-08" version="1">MEHLHYSKPVKMSEAINDMKAFSQMTDHVFNLIRNSTDPKLEKSRDILTNVLKRKLYKCVGQTQAKEKQMKKEYNIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EU08</accession>
    <name>A0ABY7EU08_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_026624</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF88">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR12444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="214" mass="23807" checksum="69627930ACFED45E" modified="2025-10-08" version="1">MIATDRAVKALLAFFSIFNGRAVGAGDRDGIPPRQVCSPSTGNQTVYDFRFRNVYNNETFDLAQFRGKLTLYHGLNALQSQYGAEGFQIVGFPSNQFHHLEPAWNGEDLMSGIRHNHPGGGFVPGFPLTWKIDSLCPATTRKIVTPALYSPVLMTDIRWNYEKFLVGPDGRPLFRYSPDFETDDPQLNADIRQQLDAIKRNNGGHGGDIVGIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EV61</accession>
    <name>A0ABY7EV61_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABHD4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027290</name>
        <name evidence="4" type="ORF">MAR_027307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR13127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="250" mass="28427" checksum="DDC36C7BF3D5257B" modified="2025-10-08" version="1" fragment="single">MIVANKDKPNTPLVMVHGMGGGVGLWVQSIDDLAVKRPVYAFDLLGFGRSSRPKFSSSAKLVEMEFVESIEEWRQEMKIEKNGFIRTQLSAYALKYPENIEHLFLVDPWVFPERPTGESDRSRRIPTWVRAIAKVLSPFNPLAVVRVAGPLGPGLIRRFRPDLQAKFAHLFDDHTILDYIYHCNAQTPSGESAFRTLSLLLGFAKRPVIERISEVDKDVPITFIYGSKTWMDKECGYQTKFLRADSHVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXM6</accession>
    <name>A0ABY7EXM6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47773:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47773">
        <property type="entry name" value="SI:DKEY-9I5.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="209" mass="23830" checksum="7272348CACC58002" modified="2025-10-08" version="1" fragment="single">ELVGVQYLYDQTGQELLSIAKTREQLEEDEDQQEEDSHEDEGFVEMPLVTPPAETALLPPPEETAPRPPPETAPMPILHIPSEAEHRQMTMDTVEGFEPPEDTNTPSSNVHVTPSLEDSNTTDQSSDVLGPDNKPGYDKVLNFAKFLVELRDERDLCDNKVQQLIYLWEQLSRFEKKRTNFPRRYTKKQWSGKFGGRRKHVAPGVESIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EY61</accession>
    <name>A0ABY7EY61_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ING1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_004983</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="529"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR14878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="587" mass="66431" checksum="3C0347A636FCF8AE" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZ88</accession>
    <name>A0ABY7EZ88_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="68" mass="7490" checksum="54C57662FDCF6414" modified="2025-10-08" version="1" fragment="single">MSSLTLEHHHSLMSSLTLELHHSLMTEPRVTAPTNMRAALGESVSLVCDAQGFPAPAITWYRKDGEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1Q5</accession>
    <name>A0ABY7F1Q5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTPRS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_030707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="132"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR16113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="200" mass="22854" checksum="25B4AB85B03CC96D" modified="2025-10-08" version="1">MRQNRPNMVQTAEQYEFLHLALVHTLILDCEQIPGKQFQDYMIETSKGDLIRQFEVTEGDEYRLRLYLGIRHEDSDYVNAVFVHAFQAKRKYIVSQSPMPNTSEGGKSTSRHFEFTDWNQTGNAPRSPAYYVTFLGDVKMSSSNGPVLVHCRDGGSRSGLFCVMAFLLEKMEEEHEVNVVNAVRKVKAMRPNAVPTQLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2U6</accession>
    <name>A0ABY7F2U6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="59" mass="6927" checksum="1359B5E86DB6B4A7" modified="2025-10-08" version="1">MTLTLQKDMRTTLEILIRCKFRSANIGRSFLGSGCILTNANDMAKWMKFWEKRQQPECD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3Q2</accession>
    <name>A0ABY7F3Q2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_031412</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR16818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36091" checksum="F050C50BFB97448C" modified="2025-10-08" version="1" fragment="single">MASNNSTQTPVVLINDGYDIPLQGLDNGMFYFIQVPAIVCLTMSLICALATIIMSFLSHPAAEFYTRWTRGERLVVYISVFDSLFSISLLANHLQVLITKMHARPKELCTFFGLITTEFMLGQILMVNVVAINIFALMFFNTKISFGKFDRGILLWSFGVPFIGALIAALLEQFGPMGIICHFDAVNGQVGGLVLITIPLTTIMLANVLLYILTFIKIRIEVIATREILGKMTSTAYRHIRAARNMSMFVASLFVQWSFIAVVGIWNMFVDNSAEVPVILNLFIMVLTKSGGVFNLIVYLAVFKKEKPMSKIATRMETQKTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5K8</accession>
    <name>A0ABY7F5K8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_030577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046487157" description="EB domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="33"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR15983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="86" mass="9301" checksum="2103E931514F419E" modified="2025-10-08" version="1" fragment="single">MEPKYWLLAVVVMVAMSYASVEGAFGANCTEDMLRNGECAAKGYSDACQTNQDCQLGNVGANATCKNSMCDCMDGYSWKTDMCKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7F8</accession>
    <name>A0ABY7F7F8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_031903</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR17309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="189" mass="21238" checksum="83DDCA7147D4BE46" modified="2025-10-08" version="1">MFYGFKVPITFKNKPGCKMIHFLNHWLVITSGALLLFVAIDRYQKICRPFRWHLSIKSVNIAFLVIVNAAMVYSVGTISIVDVAHVNVTEEESGKRIEAFYCTHSKDPGLKTAINLFHALDLLAFITIIGGCIVLYVLISRALWVSRKHLKHANKGRCSNDSNLLLPVYGILNPVANEKHQFLALSAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FC00</accession>
    <name>A0ABY7FC00_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_001498</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="7">
        <location>
            <begin position="131"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR19660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="395" mass="45822" checksum="72FE69978463E351" modified="2025-10-08" version="1" fragment="single">MTKHNQREEITHRCGYFHGCLPFFLLPTFFFFIIIVIIFFFFTFFLFIIFFLIFCFLFLLFDFNLSFFFINFFFTLLLFFFILFFISIFLVSFKVHSTDFPGSYDGYDDAWNKEKFEKNFRIEVGRLAADELEFDMIGIDAAIANAFRRILLSEVPTMAIEKVHIFNNTSIIQDEVLAHRLGLIPIKADPRLFQYKQNLTSFLLLIADADPTEEDTIQFELKVKCTRNPKTDDPDNMYKDHKVTTRHLKWVPIGNQANIFKEGDIRPVHVTEDEPILIAKLRPGQELDLKLFCVKGIATASYRLLPEITLLKPVTGELAVKLQKCFSSGVIEIDTVDVNVESTGILPPEVLVSQAIQVLMTKCRDLSRELDETDKMEMIQVQKGTSEDEAQSFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FC37</accession>
    <name>A0ABY7FC37_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF1">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00811">
        <property type="entry name" value="Ependymin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="506" mass="57549" checksum="18764DE3BD559F8C" modified="2025-10-08" version="1" fragment="single">TDRYKEFAEYEGYAYDETNKRTRSIEEIEAGREREIYDILRLYNSNQEYRVNLRTKQCNMTTIDHPFRMKGVPPGSKFLFESVLGAAGIPGEFITAQTFSGAFEDGAQYVVTVTTPDCVPIIFNIESNKTDEHYEDRMSTGLNSRNKRIADLIFFHFLATFFRLLLAGSLAVESLLTEAAWLYLFLLHEALADGHSEGPCHPATHHWLILQYTSLLILYTKQNIAIFNSTYGKVDRCFVDLNTIPARGFTFLLLLQPPTLFLNSKICTIEHYLFWVEFVFLLFEFPGDFKGGLELNVGLVIINPHTSKVLYLHCRDRGDMTALTRTGTCGATGAGNPVGTCASSTRSSPGIGSASSFTIPRPRDLKYRTPPRRDCRYQTLHPSPPTYVPVITERNWYWERKYRIWQTVMVLSDHVQGLALKKASELAVPVCPHTSDYDQPTPTLITQHPPCCRASSWFSASRARCWSYVGSSNLWLGIARLLAMRSSRRRSRSFSRSDCLANHSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDW7</accession>
    <name>A0ABY7FDW7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="110" mass="12492" checksum="DE9FA42F73AFE913" modified="2025-10-08" version="1">MTMTWVQLKDFQCPSKQCPSKDPFTWVCKADKEDMYINERGIMECFPGTHSGNVCEWGWNCGSDFHKGQYFKADIEGFTFALSQAVQLTGKMGSEWVASLITELGKQYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FES1</accession>
    <name>A0ABY7FES1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="270" mass="31667" checksum="9FE1FB62873CE9E3" modified="2025-10-08" version="1" fragment="single">MSSGILSARSRSIRENETPLSLPLAEDSEKRAVAAVYRKHADYIKQNVQLTRTHIRKLLTTGGVITQREFDSLCHQINRIFSTMSTNMNYRQFRCQTPELATLDKIESHTKSLLKIIDDCCKQFDLQTSKKSLKSSIIDLKLDRDNIFRKSKDQRSFLETKLRNERDKNEKLETMVKELQEFKDMFEGYTKAREMSQALREMKTEKKRVTDELEKIKEENKQLSRTLETTQAVLDIYKENATRAENELDRYKKLVTRLENDNGELSLKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFS0</accession>
    <name>A0ABY7FFS0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_014901</name>
        <name evidence="3" type="ORF">MAR_015007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="144" mass="16001" checksum="852ED4F1C13A192B" modified="2025-10-08" version="1">MDLISVVLNSLVAIPFLISTSEKETPPPLLISVLCLNFVCNADSDSDISVPVYPNVLVDSPEERDRERNGKRRDVDDSAQDTRLARPDLPSKWSTHLPMMGNGYLYQYCCVRISPGIVVSVLIKSKKAKHSTNLGTNAERYGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHP3</accession>
    <name>A0ABY7FHP3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFGM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_015574</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058727">
        <property type="entry name" value="Helical_Vwde"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF335">
        <property type="entry name" value="EGF-LIKE REPEAT AND DISCOIDIN I-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26129">
        <property type="entry name" value="Vwde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046565733" evidence="5">
        <location>
            <begin position="22"/>
            <end position="1972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1910"/>
            <end position="1932"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="167"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="586"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="900"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1246"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1250"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR21600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1972" mass="213039" checksum="B4F16F9EB5531DD6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FK49</accession>
    <name>A0ABY7FK49_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="428" mass="47622" checksum="E12FD0178F8EE8D3" modified="2025-10-08" version="1">MAALFVARRQNARRPRVFKERVVAIADVPDWECVGRYRLTKDAILRLEAALHADLEPSTNRTMSVSSMTKVLVGLRMLSKGNFLSESADIHGISKATAGRFSRHVQCSKANFRFQQPLRVRVLSKPHVFILVLHLVKVVEQLLLAAVQGIQQVFILVLHFMEIVEQLLLAAIKGFQQVFILVLHMMEVVEQLLLAAVQHVFILGLHFLEDAEQILLAAVQRYTLVRPGFVELGKGYERQQQMFGLQKDPSQLLYRLSPATNKGSVLDFGQARLLKAPRLSTYTSTFRTMTNHITVDVSGILSNTDPDFLSDVDSTEDFQVMAVQSVYCYQCCDKPACRNEKIADGKYPPCNKMPDTEKHYGSAMVILKKKTAFHSLTVIVQGFQLRAAAAEVGSTASTTGVVSLRATAAKVRSTEGPFAAVVPKHTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FL85</accession>
    <name>A0ABY7FL85_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="585" mass="66076" checksum="E3152B6E1D3D6C9F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMC7</accession>
    <name>A0ABY7FMC7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">OAR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_016288</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="70"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="252"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="333"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR22314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="468" mass="52938" checksum="2D763F3FB59E32CA" modified="2025-10-08" version="1">MSFASYVLHSGASWIINNISENGSFGAMVIQNTSNNDTVQNEIKEMRYITVLNYLLYVIGVLITLATIIGNVFVIVAVISEKRLRKVGNVFIINLAISDCLVGLIVSPLAITYDITEQWALGEVVCDIWVSLDIVCCSASILNLCAIAYDRSNAIVKPMKYARKRTFKRAWCVVIFVWVYSVLIAVPRFLGWRKKGETGLPDGKCVISQDIGYTFYSILMAFVLPMVVMLYFYYKIYSATCVRSSQWHQRPGNNHFKDTQVKGRDRSYSSSTEGSRSFSSESRRHSNLRGHRLSSARHSSLHQEVIHEIASAAQLELQDESEQPTGAAKLKMMRQTGTVETDDTHDELSDDGQGTKQRVKRKLKSSTLRRHNSRKSKKIAISQEKRAAKTLGIVMGCFSVCWLPFFLITFLRVVCYDCAIPSILIKSVMWLGYFNSACNPFIYTFFNKDFRMAFRKLSCKASGNVVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPS9</accession>
    <name>A0ABY7FPS9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_036372</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF116">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="188"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR22703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="288" mass="32771" checksum="21A9D68227043FE0" modified="2025-10-08" version="1">MFAPPLLRLSNMADELLKRLCTVIEVLILVVLIAMLCIVWTKPDCRHTDSDSEECLFAYDGAEKQEQIQTETIIKVDSTEPSCPKYNLEKRLIERVIKNEVEIKHLHDDISTVREEIGEMTRRINQLDLASGFRFEQLSQSLIENMTRSLAELETARDMVTEMTRLKGASIWPPKIQFTANSPFDKYLDNGQTIVLKNVVINDGQGYDPNTGIFTCPFSGEKYSHVGIVKDNTLLIAGVAFGTEWYPCSSMQAFVSLKKGEKVWSKANWESFLFHSETRWTSLSGMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRY4</accession>
    <name>A0ABY7FRY4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12141" checksum="4533091B451C536D" modified="2025-10-08" version="1" fragment="single">MCTMLNMTFTHSLTSWYGPGKAPMLVDNLDCFTTNLSQCTHRSPYRGGCIEGYVLSLFCSECGEANLSHGKITSYHNRTLTVECDEGYDPSTISLQCVNAAWSRNATCIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FS49</accession>
    <name>A0ABY7FS49_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AASS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_010757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="2">
        <location>
            <begin position="86"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="306" mass="34856" checksum="AF0B4D05801176FF" modified="2025-10-08" version="1">MYRRRSTAIKPRKDLTTYTLDTGSELREVILHFNINRQGNVYTYNQRRIMWRQKSHTLWQHLNQPSVSFGHQCVRRISGSEEPVLAIRRETVNVWERRAPLAPTQVQKLVKHGVKVIVQPSNRRAYSMQEYSDRGAIIQEDISEASVIIGVKQVPEDLLIPDKTFCFFSHNVRLIDYEKMMDPAGQRVVAFGKYAGVVGMINILHGMGLRLLALGHHTPFMHIGPSHNYRNSEAARQAVRDAGYEIALGRMPKSIGPLTFIFTGSGNVSKGAQEVFQELPHEYIEPDHLPKVVKKGYVCAIHNCDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTF3</accession>
    <name>A0ABY7FTF3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="363" mass="42050" checksum="F81E16A8D35844CE" modified="2025-10-08" version="1">MTRLVLCRVASHASVQYPCFQKKPNQSTQRLKTAYTQRDTQLHKTEYTERDTQLHKTEYSTRQSTLNETHNSTRQSTLNETHNSARQSTLNETHNSTRQSTLNEIHNSARQSTLNETQNSARQRTLNETHNSARQRTLNETHNSARQRTLNEIHNSARQRTLNETHNSARQSTLNETHNSATQRTLNEIHNSARQCTLNETHNSARQSTLNEIHNSARQSTLNETHNSARHRTLNETHTTARQSTLNETHNFARQSTLNETHNSARQSTLNETHNSARQSTLNETHNSTRQRTLNKTHKSARQRTLNETQIRKTEYTERDNAVIQRTHNETHNAAIHKHSTRHATPQDNEHATRHTTQRDSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTU2</accession>
    <name>A0ABY7FTU2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FBX7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047118">
        <property type="entry name" value="Fbxo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15537">
        <property type="entry name" value="F-BOX ONLY PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15537:SF2">
        <property type="entry name" value="F-BOX ONLY PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="214"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="390" mass="42443" checksum="0D56257ADBE07E6F" modified="2025-10-08" version="1">MKFRVRFQGITRIYEVDDGVKDFVTVGDAAATISALFSDNLFSEFELSLNKKDPLERTSTLIGDCGLVGGDLIHVLTDDQNSPSSDSKTKDTGQGSSSSCDDGSRSSQSESPSMFPHSTSGSSSSKDELTSGYKDIAMTTSDVDMDTEESAVDLAVVQQCLSEPVLCREAGDGQVPALLIEVFQSLQPQGSAEMLAVVLHVLMLETGFTLVQELKILSHLDVRSILQTSCVNQELRGLSKDPFIWRRCYFRDFGNRNDNSLSQDWKNLYKQALKARKERRKMMNKMTMIVPPFCGPQNPFSGPSNWMPPVPGGIIGGDYDLYPNFPSSLPGIPGRLGPLPPVLPRPRYDLMGPGVDPGPHPGLLPSRPSPRGRGRGGGMFGGLGPRCYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTV2</accession>
    <name>A0ABY7FTV2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PSMG3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_038248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018788">
        <property type="entry name" value="Proteasome_assmbl_chp_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10178">
        <property type="entry name" value="PAC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="133" mass="14400" checksum="9F7113797659699E" modified="2025-10-08" version="1">MAAPMSNENQHIVSSPDSFPVRTKQCAVEINNHKTELLCSQFGDRTFLVVTQYNKVGTLVSVTNARVTDATGATASMPNIDVLMGNDQPMTHVVARNLITQIPLSKPILLSIALKDNSPKTVKAIAKILPTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUY6</accession>
    <name>A0ABY7FUY6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_038330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="96" mass="10683" checksum="7C4025A75828061C" modified="2025-10-08" version="1" fragment="single">GHLFIETPGSHDQLFIETPGSHDQLFIETPGSHDQLFIDTPGSHDQLFIVTPDSPGSHDQLFIETPGSHDHLSKIAQVVMITSQRYPSSSWSPLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FV86</accession>
    <name>A0ABY7FV86_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WHRN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_010888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051844">
        <property type="entry name" value="USH2_Complex_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116">
        <property type="entry name" value="PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116:SF29">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="238"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="342"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR25184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="637" mass="72535" checksum="0C43D8B51B9EC513" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXY2</accession>
    <name>A0ABY7FXY2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P3A2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_011863</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRF1/Ewg family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039142">
        <property type="entry name" value="NRF1/Ewg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019525">
        <property type="entry name" value="Nrf1_NLS/DNA-bd_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20338">
        <property type="entry name" value="NUCLEAR RESPIRATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10491">
        <property type="entry name" value="Nrf1_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Nuclear respiratory factor 1 NLS/DNA-binding dimerisation" evidence="8">
        <location>
            <begin position="54"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="483"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR26159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="511" mass="55428" checksum="C8D4A3C25A9C1CB5" modified="2025-10-08" version="1">MNQNSMVSGHAQMPTNEILSDLSEPSSPDSTIYDSEILGSAVNDDVTNQLAASGPIGVAAAAAVLSTRKRKLHPHHFETNPARRKRQQTRLLRKLRHTIEEYSTRVGQQAVVLCCTPNVNHSMMMYKIRNNKPQILSDLESALLEHTPPSQAENSALHELPSLVIDGIPTPVDKMTQAQLRNFIPEMLKYSTGRSKPGWGRIECRPIWWPSDLPWANVRSDVRTDEEKKRVPWTEALRQIVKNCYMHHGRHDLLQVFKEEPQSGVTVQHQQQYAGTMMQTINNPDGSVSIIQIDTPSQMVTLPDGTQATLVHAIHDNNGVPQLTSEQEIQISQSFTDTSNMVAVSAATQEVASQQAALGALQASLNSSGHIILTGADASQLSGIMTVLPVSMYQTVQAVQPISTNIPMNSIPVNNIPVNNLPVNFQLAQSSSQPIEVSMASVSSDVTMAINQHLQGGGEGQVLGVAEGDGGVSVEEVGMGIGVKDETGAQGEGEEGSPQENGDSSEMHMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FY40</accession>
    <name>A0ABY7FY40_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MUC4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_037725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF52">
        <property type="entry name" value="MUCIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="AMOP" evidence="6">
        <location>
            <begin position="183"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="7">
        <location>
            <begin position="332"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR24056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="414" mass="48225" checksum="BDB81F0C2C69E80D" modified="2025-10-08" version="1" fragment="single">KPSPPSDRLDLSKFGERVLIAPYFANFNRKNGLVSFRTYDIFNNNQELEDNRDVISMVDHIVQKFGGLQSFSTKFLLIATWENLQKGQGQNVDQESVTFQMNLASNGSYTFALFTYGNERIMWNMEKKQDPKIWIGFYAEKNRFYTHPFSFSNNALRMDTVEIGQSEKLKGVLLQPLTQYGKTKPNYDVNCISWYNRNSHEKFRMNQISSLLPHCPCDIDLGRFDPWFWNLQKYRWHGQQGYGCVDMLQRPDSIYTQYGKSCCYDLNTRLLVFERPYAGSFRMFNPHILTNEKQHYENDILPKEWCCNLSDFCNLYYELRPTGSCYRKSPYSFGSFWGDPHFQTLDGMNFTFNGLGEFTLLQIETANMSYYLQARTTRAVKQDGNVSDATIFSAFASMDDTGANIHVELNQAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G064</accession>
    <name>A0ABY7G064_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_038415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="208" mass="24061" checksum="87B68C0B45EE7FE1" modified="2025-10-08" version="1">MAKMFFREIMQDSKQKPSNPDLKKFKTSTGSPILYTRFRKHRGIYYPLAKHYQGSKTKPKQNHKHACVIYSKTYGREMYGNIDIWPEDEHAKEKLLQKLQALSMEEEEEENDVGIDIPRALDEMNENKVLEHKYGTEHGTRTKSPNGTRHVTIVVTDASEEEGEEDEEEERTYPTSGEHSPIPDPDRPDTPAGEEGSWPLKRSQRCIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0A7</accession>
    <name>A0ABY7G0A7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046919624" evidence="1">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="134" mass="14855" checksum="10C4E5B86B1A20FC" modified="2025-10-08" version="1">MAFMKSVWFICLLIHVCWTESPPTTVEVTLNVFSGRPDPDVVLQPNDDNYDVIVLNAGQQSTDLPPVMGYKGFTIMEYHGLTLSRTSTVGRCTRPDFELLLLNSITGKVPKGDDQPISDSLLNYARSDIENCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0D4</accession>
    <name>A0ABY7G0D4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="101" mass="11522" checksum="499A477C27715827" modified="2025-10-08" version="1">MRIRKKMAEQVYEYNSGLSAEIITHILGKNNCDLVHLDENVPRAKVVDHVSSSFQTDLRKVRWKKNGASATNGDITHLEEEGEIFIRQSAHTDLLIWSGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G156</accession>
    <name>A0ABY7G156_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MEST-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="39"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="215" mass="24208" checksum="228F28E41C126F04" modified="2025-10-08" version="1">MSPFFCQLSSVDESGGGGMLRKYTVAAILGRMKSQFSKIIMLDMLGYGFSDKPLDHDYLITEQADIHEALLTSLSISRAHVMSHDYGDTVALELLHRFNNKESKFQLESMCMLNGVRRKNGNVVNSRLIKYLNQRAENKDRWVGALVQTKLPVHMIYGPSDPVNSGYAFVDHYKKVVPSPSITVLDAAIGHYPSWEDPNAVYESYKSFLQAIKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1P7</accession>
    <name>A0ABY7G1P7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CLCA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_013546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013642">
        <property type="entry name" value="CLCA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF177">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08434">
        <property type="entry name" value="CLCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="484"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1333"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="110"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="771"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR27842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1425" mass="156753" checksum="2A9D7F55F3939592" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6G8</accession>
    <name>A0ABY7G6G8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="95" mass="10261" checksum="8735A36523FF4436" modified="2025-10-08" version="1">MQRLEAKKGTITNNLPEEEGDAGSSANVSQGHRRGFGSAENPEDENIPGIVVSRTNLKYSIEKNLLTDVALAMHSGISVQDILDDIASKKVDPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7Q6</accession>
    <name>A0ABY7G7Q6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRI33-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_002796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR29228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="199" mass="22780" checksum="983E677F5C2DE2CF" modified="2025-10-08" version="1" fragment="single">MATGGSSIYKGSDLIHDYSCSKCEESDLNTEATHFCPQCEHYLCDKCVNLHNGYHTKHTVYGRGDIQKWVGFSFDRCDVHGDKLKVHCDDHQELCCSVCVALNHRLCSSISHLPDLAMFFLNTAEFMQLPEAVDNVRCRLDKLTNAMIKDQVSLKDSYKNTIAEIKAFRKEINTILDKLEKKTVEQLDRLMKDLKKTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8T0</accession>
    <name>A0ABY7G8T0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="55771" checksum="9730223C1171A52E" modified="2025-10-08" version="1" fragment="single">MLNELCFAFGRKSSVVSSTCNNICKQLKGEIKSALPKENCVVDIYPAYCIDSDREIVFVVTLKEEVDTSLLKRNVKYRIEIRILGKPCSELTYCRKKLQEIVSIDDQTKVQRCLSAISHILLTRHKYLSVITASSVKSQHFVKKEKKSDITQQLCIVLCVHAKGFIPIDEDQFPDNYKGIPTDVMEGSFTSFCKTANEKHANLRMGCEIQRKVNEVTGTLGGFIEHPEYGTCGIISAHVALHSDELFECKYRGGHLKLHHWPERYVNDRAIYQPAAYDESQPIGQLMEAIYIEGDYSTSGVDIAIFQITDRFPADGKFPAQSRNGIKEPTTLEYKSGKTTGSVITSNQTLWKYGKTSGQTRGQMVFRIPFVSVKEINFNDKSNDFQVIQMKLYEVTSNDERSFACPGDSGALVFLEKDDLDCVGVIEGGFKGGGPVFVSPINSILKHCNVTQLKSFYPSQGEMAASISELQTQVTNIEQTMATNFSEILRKLEEIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G993</accession>
    <name>A0ABY7G993_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_013510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="326"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR27806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="549" mass="61245" checksum="91FECD0505F6B3AF" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GDZ1</accession>
    <name>A0ABY7GDZ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046840913" evidence="1">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="116" mass="12226" checksum="11662BE928BE6844" modified="2025-10-08" version="1">MKLVIVCLVCLAIIVEGQLPHSNICRHGTAGTCLGYTNQQCPPNSECRRVSGTYGVCCRLSNTNPGGGCRCDNGQRGRCGGFQGLRCPRGTTCSCKGPIAHDGFGKCCINRPGNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GEH8</accession>
    <name>A0ABY7GEH8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="48"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="12341" checksum="C36F2DF91CA584A3" modified="2025-10-08" version="1">MDCRPSNYSWIEIDAIQLRGYPPDCGPFTLGKQFELAATDVSLPQEVTPLSHVTTGSQMVCGAECLKLPGCGSFLLLPDSSQCSLYSGNHLCALVGGSKIAAYSLFTAVNYLLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GFH5</accession>
    <name>A0ABY7GFH5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YMD3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_034393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="561"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR31851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="599" mass="66222" checksum="50DC947094A5A7E8" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GFM6</accession>
    <name>A0ABY7GFM6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLPP6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_034268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd03391">
        <property type="entry name" value="PAP2_containing_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="3">
        <location>
            <begin position="98"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR31726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="232" mass="25957" checksum="BFD768BEA9C3356F" modified="2025-10-08" version="1">MSTSRIRTKGKDSGKANGHIGGKSKKRKSANDSSSFLATILQLDEKYTSICAICANKDSPLSLLRPVMKLLEISCHGIPWLTGTVLLILSVHLAHHVEMSVNLLFGLILDLIVIGILKVAFRRSRPKHNEMDMFATVSIDNYSFPSGHASRAGMLACFFLIEYLSCPTKELLILAWSFTVTISRVVLGRHHLIDVVCGYGVGILEYLMLVHLWIPQKTCMSWLELYFSHFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D8E0</accession>
    <name>A0ABY7D8E0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CP20A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052666">
        <property type="entry name" value="CYP450_20A1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24280">
        <property type="entry name" value="CYTOCHROME P450 20A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24280:SF4">
        <property type="entry name" value="CYTOCHROME P450 20A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ93639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="286" mass="33367" checksum="8B235A03747BC512" modified="2025-10-08" version="1">MQLHEDYGPVASFWWGPTYTVSICEEDLFKQHTNPLIGMKCIQYANGQEGRARRRHYDTVFTHEATKKYFLDFQEIADELVKKWDGLVKEDHIPVTEYMTMFTLKAVLLSLYGKYMKDDKKVVEFKHIYDQKKMFALTNEIVKHRRAHPPEHGEELFLDVLLDGDNDEVISCDALAYDIQEKVYKEIKEKLGNDDVDFSTMNDLVFDPDRFAPEKKHLHHLSFVPFGFAGKRKCPGYRFAYAEVTVAMVTILRKFKVKLVEGQVITPVHGLVTHPSDEVWITISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D9N3</accession>
    <name>A0ABY7D9N3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_006828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ94357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="299" mass="33292" checksum="84A10745F8711C06" modified="2025-10-08" version="1">MVVLERNIMSLTKQECEAFWSKADKNGDGKLTIQELDQGLRSILPPGKGPSSKDVVSCVTDNSKVHELELAVGRSMVFYNMFYIHNLRTYRCMDSGSFSKGCDVKKVADAIMEEADTSGDGAIDLKEFLKVSHGNSLEIKEPSGNGDGFPYDKRGTFLPDCCVFYRIVSFNTDPNTVVQTLLNISTLHYPSLQNWSTSDSLHYWSRLVNIYPPHDPSLQNRAGQHLISALSVITSKHLHPALPFLAQLVTVYSLPSWPTELVEDTAADLMCSRNDSDGYLIQEFSTSDGNSVRREPDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAN3</accession>
    <name>A0ABY7DAN3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38564">
        <property type="entry name" value="SI:CH73-250A16.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38564:SF2">
        <property type="entry name" value="WU:FC46H12 PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047391085" evidence="1">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="127" mass="13844" checksum="4611ACB7247C80CA" modified="2025-10-08" version="1">MEGLAIVFTALVAVFVFVEGGPLHASCKIQWELPAISDVSDAEIKGTHETPVKHYKDDISFKLTKAGTGCNGFSTSETWYAVLDYGTNYCNLENLITGAGLNATANYKETTSDDVCTQYSSHDCEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DB56</accession>
    <name>A0ABY7DB56_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">PTH1R-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_006416</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="12">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="13">
        <location>
            <begin position="86"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAQ93945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="347" mass="40346" checksum="8320799C60AD1009" modified="2025-10-08" version="1" fragment="single">VYCNQTFDDIACWPDTPAGTVQYIACPTYIQGFYTDGNATRICLPDGKWFVNPVTNSTWSNYSQCLKPTNPQEEIPQLFMVHIVYIRVMSTTGYAISFCSLLLAVFIMLQMLDFKPIKLFFARRLHCPRNTVHLHMFVSFILRAILTFLKDLLLVQGLGFAFDLEQTGDKLVFKQEGLHWECKLLITLFHYVLSANYMWILVEGLYLHTLVYVSVFSERSTVRWYYLLGWGTPFLSIVPWLLEYKSNSGVLLDIKGTNLAKYYGKIVNFFFFINILRALFYKLHKPKLRKPCPSAARHNRYRRLAKATLILIPLFGVHYIVFMGVSENVNPTTEVVILYIEMFFNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDK6</accession>
    <name>A0ABY7DDK6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ZN658-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_028078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF64">
        <property type="entry name" value="LINKING IMMUNITY AND METABOLISM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="726"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="755"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="856"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="885"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="997"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="1026"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="1113"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="1141"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="1169"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="527"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ95388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1313" mass="146733" checksum="2C8378E757FC5105" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DF00</accession>
    <name>A0ABY7DF00_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CSMD3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_028912</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF4">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="105"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="170"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ96222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="232" mass="25476" checksum="543A3BFD6754C43B" modified="2025-10-08" version="1">MATYKHLTSNYNQSFISYSKYFSELEKPHEADRNHSNTDMDLSLSVRSDGTRREPSSFSENCHECSKPHFYPLHHPPPLSLPQHPSLAYQPLFLCIFSFNQSIVIFCMGNITITDSNNNNHSSSPVSGPYVEGDTVTYTCSTGYAKTAGDLVHTCTSGAWTGTLPTCSILTCVPASVPNSSKSPDQATYDYATSVTYSCTTGYEHTGGDLTRTCQADTTWSGTTPACSRMHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DF59</accession>
    <name>A0ABY7DF59_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_028972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="150"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ96282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="367" mass="41328" checksum="CC661A04EC5DE2D4" modified="2025-10-08" version="1">MLGKGMTKSYPGEMYNTSLYKQLPVKVLLKQNILGKMALVCICASCDNAFHRVYEDVSVTDYSKWKNIDLGYICTTCRTVDGKRFDFFDGFLRLQLAAQNGSFENLRKAVDRELMFRQKLQMPSTLVDRYPRVDNSAAMVLDNYVDDIRGTPHKTSGDGDCLFNAVSILLKNDESLSVYLRYHTCIGLVLEMNFFKNHPLARLIRDHSGSYTSACLDSAKLGSASSAWAVLSLADAIERPIRVIYPHVNGRDDHPHISLNRVFETETGRDHPPLYILWHGYGSIPVPGQYTIVNHFSEVSGVSPKEDQFIPVPEPERVGKQKASTPVHISDTSLSSLDMSAVKEDCAPKSTTWRMPKRKPISRKDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DI06</accession>
    <name>A0ABY7DI06_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="130" mass="14532" checksum="FA98B3DDF2D70975" modified="2025-10-08" version="1">MSVLYGDIASIVYYELFVPKPSTCYIVDNNPFEDIWRTCNTCVAGRSAWVTMMMEAETSVTTHTSGHLSPASSTRSACTWTIISGRTRTTSTPSASRTRTRRSRPTKTSGIFLHTTPYGNSNMPIKQYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIT6</accession>
    <name>A0ABY7DIT6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MZB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052682">
        <property type="entry name" value="MZB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15881">
        <property type="entry name" value="MARGINAL ZONE B- AND B1-CELL-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15881:SF2">
        <property type="entry name" value="MARGINAL ZONE B- AND B1-CELL-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ97552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="366" mass="40551" checksum="CEDCCF61100D0984" modified="2025-10-08" version="1">MPAMVVATVHKYRVQDVYGRRLLFLLQIWLQVQTLREFIPAVQNQGTRCQDLIDNKKFSSPNTPPTVTSIDSETDDIRWLLTDLLNDSVVILGHSSTSDSYVESSDVLLSDADVCCSNDATPKSQKAQRKDFAAIARSTCVPLPYTYNVPMRHHVWDGLARFFTLDSIPDSSFDVFVLISASVTMRTGPTFGLFTACVLVFGGGWGVVGQSVVTQNDDASEGTISFQTPTLNDEEAHSVHMPSHLKCDACTAVVYQLSKGFDDFHGRRNYGVKEVKKVKRLSGPGLETAESPGIMAGGGKWPERMKRMCNLYVEEFDEERIYAEYKAGKGRLQKLLCANTIHSTLTDVCLDLPSSSKKVTSNKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DK66</accession>
    <name>A0ABY7DK66_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondria-eating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_022485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ98112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="34220" checksum="9C7DBBE7584D18F9" modified="2025-10-08" version="1">MHYTSNASPQSAAYLPIRLYLADCWECLNIIFTWFRLIKCVKFLRDCLKFKNKPEYQYRRLSSIKIDRDETGETVHRLREEIEHKDNKIHELQEQNRKTALDKRHAEVSFTFCKTELEANWQLVSKWYLDDKLYTLLCGLCKLESLQFVLSSCQMKEYVATCVKLSLLMNANDPPVAIECPGWVPCISQKESIYQPKHEEESDLLTHEGNAQIPTNVDGDGSNQTYTSDLKERRTFNKELFKEYTVRGKYVEFFVWPVMYLHENGPVLAKGIAQGAEDKVISDDDHRWVWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DM19</accession>
    <name>A0ABY7DM19_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CL004-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019311">
        <property type="entry name" value="Fy-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525:SF0">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10154">
        <property type="entry name" value="Fy-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ97405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="327" mass="37672" checksum="3692E7E98FCD4324" modified="2025-10-08" version="1" fragment="single">MPLSVEKEFTYVFTSKDVESVLRVPVKIPYPQDARDLTGRLVFEHNLPCYIEDDLCTKIEKFISVETSRLSDENANEALERVRCGEVDVESLAQQWETVFVQEVKQFAPAEEVSSEQHFSEVYHTLIHSPALETLLNLEHTYALTIEDLIHQRDKDLQHLEQEQQEEMKTALSRVGTSFTDEQVNQLAQQNFELTQMMESKWASELSRQQEIQRREYRDWVMKVHEDSKGIGTPTQRVRAMTSNLVEAGMEERTAQTRVEESFTIILGAQMKTTHNLRLLCTSAMDLCRHKPHTVGGVTMAQPQRLQTAMSLYSNNLNGIILLVDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMN1</accession>
    <name>A0ABY7DMN1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_022791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ98418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="60" mass="7020" checksum="FB2204C782982BF4" modified="2025-10-08" version="1">MEKMSKNNEYNWIGSTKSENLAVFNIYDLNVFLRSFIENYFGFTQHGVVKGVQTLLELIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRG2</accession>
    <name>A0ABY7DRG2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ARAP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052227">
        <property type="entry name" value="Arf-Rho-GAP_ANK-PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45899">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45899:SF2">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="305" mass="35224" checksum="25F93DAFBBF5920E" modified="2025-10-08" version="1">MTEYTSLDVADTIADLKYGWKKRWFTFDGTCLKYFESDKGNGAKFQFELVCVDRTYMIGSDTEETSIAWEQTLENAIQNYKESQPSAEFVVGGDMQRPDLAGFIRFDNNSLPYYVALKNEVLKYYRNEEDYNFCSAIHEIEMGMTSVKEIDRVTISLNVANNQSFTLRFDTVQDAANWVTAMTSALGKALGNTKTKCVSLKLTENASIATQLLLDEIGNERANTFWYKNPPDDRQITRETPFMIRRRHIHEKYAQKKFVDRSNRDLQEKIDCDFILAITSGDILNVMKLFFWGANPWSWLGNIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRV1</accession>
    <name>A0ABY7DRV1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">POLR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="689" mass="79345" checksum="24AD033675BB8916" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSF2</accession>
    <name>A0ABY7DSF2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="101" mass="11705" checksum="D64487AD9C90087B" modified="2025-10-08" version="1">MEPELKKLETEHLQLTKDIEKFKDSDKNSAANIQRLKEANAEVKKLQKENETLQRKLEKLSNRVEGMQIKRQEAGNETSGFGARQDREKQLQEQLVLLDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTP0</accession>
    <name>A0ABY7DTP0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">NEIL3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MAR_023836</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF10">
        <property type="entry name" value="ENDONUCLEASE 8-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG-type" evidence="15">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="14">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="16">
        <location>
            <begin position="334"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="16">
        <location>
            <begin position="378"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAQ99463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="422" mass="47492" checksum="6141DEC331562741" modified="2025-10-08" version="1">MVEGPGCKLKGIKIKDKIKGQCVKRVGGNAVDKVNNDSGGRTETATLELHMSEDVLTFKKSSVDIRPSVPCRQKYETMNDVDICSPVFNFRRAFSLVREQTDRQVCDVLLDQSILPGVGNIIKNEALFDSGIKPSSKCRRDGKQLSPYYKIYGKRLCKQCEGRVIICRLGDDSGRVTYFCENCQTNDLVNKNRKLPSKNSLLGWVQTGSHISQPEMADWSCEHCTLINKDTATSCSACLNPRVDKTVEAKPAQFGAKGHVSGQGNQTMNRKRKTEDSGVEQTRAKTQKINTSVVKLENKTGFKTKIPQNGSAKTNKTQNGTTKEQSDKSRIPMCEHHKRKCSMKEVRKEGQNLGRWFFLCVVRSCNFFQWADVNFPTCTDHGKPCTIRTVLKIGPNNGKRFFTCKLPKKKQCKFFEWAIGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTP1</accession>
    <name>A0ABY7DTP1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="63" mass="6861" checksum="7F5E85C49429B2F3" modified="2025-10-08" version="1">MADQLNLAVLRIANGTNACCEVKRDKGGEAFAKIDDAVYENNIPDVIILNWDQTGVNMLPIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTV5</accession>
    <name>A0ABY7DTV5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="23">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">MAR_024686</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="30">MELC-2E11</strain>
            <tissue evidence="30">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20 23">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="23">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="23"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF525">
        <property type="entry name" value="INSULIN-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="16 21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 23" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17 23" id="KW-0675">Receptor</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 26" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 23 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="26">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046565701" description="Tyrosine-protein kinase receptor" evidence="26">
        <location>
            <begin position="27"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="1590"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="28">
        <location>
            <begin position="34"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="28">
        <location>
            <begin position="183"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="28">
        <location>
            <begin position="305"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="28">
        <location>
            <begin position="416"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="28">
        <location>
            <begin position="537"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="29">
        <location>
            <begin position="1219"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="29">
        <location>
            <begin position="1482"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="27">
        <location>
            <begin position="1655"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1278"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1352"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1926"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="2038"/>
            <end position="2067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="1284"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="1357"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1688"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="564"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="WAR00314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2085" mass="234150" checksum="7E9D1C5D89DF2821" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DU05</accession>
    <name>A0ABY7DU05_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="296" mass="33242" checksum="65B760CBEDB9BD1A" modified="2025-10-08" version="1">MDGTCISTAPCPPPFVNVYVFYVHAVSRNLSIQIIHDIAEQCGVPPLNCSDIQMDQEPIPSELNEWMCKPQEPPRTPTDRMLYFVYVLVAIGCFIYWRNIRKGMGLIMLFCILRKVYSWFCKQRKKDADKTSISVEKECIAIVISSIDISIQRRNDVMHIGGNGVLDEGQVSIVQENLIVKETEVTETGSNKIGTTKSASYQAHTVVPETRPSEKSSQSQTLVERNLFFSAKETSGVLIKHQACVERILIDKETTTSVERVTVETTASVERVPVYRETTASDVCSKLKLSDKKTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVG6</accession>
    <name>A0ABY7DVG6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ARSB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_025012</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF273">
        <property type="entry name" value="RE14504P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046133331" evidence="7">
        <location>
            <begin position="29"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="33"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR00640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="680" mass="75869" checksum="A14CBAE38D1106B9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWC1</accession>
    <name>A0ABY7DWC1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="221" mass="24587" checksum="E72B132BF15D7DD3" modified="2025-10-08" version="1">MASGSQGYRNRPVVDNWASYAPDRVRVSYRNGEGFVLFSAIFNATGSSDTDWLDMSHFLGSHAYSQVTWSTDYISYGVQLAFTDSSWGVERYSAAAVSLPNGTYVYVVPSGGTLDLLPMTLLDDAVSCTYSYEPLDANPFLVNMTVYNLNRKYCAAVCRERNYPHGALHVSFIARQAIYGFNVSVTSPLISDVSVDLVLYFRNEACNRTELLNKTHQEVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWH4</accession>
    <name>A0ABY7DWH4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ST1B1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_008633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="53"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR02075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="296" mass="34470" checksum="CC507F2C447B0FE9" modified="2025-10-08" version="1">MLLETKCQDHTTRCALSAQQYSAFNFEYFRTELSHIANTSMTFFTVKPSTCPGCTWTYEIMTMLLQGRAEGPSYSKMHVMLEASAPENLEGLTSPRFLNSHLSYSRIPADIRQKRVKVVFVARNPKDAAVSLYNMMSGMKHYSYSGSFANWLPLYMRGGLAYQAYPKYLLGWEEVYKSKQHEMIVLYYEDLKKDMAKEIRSLAQFLDLPENEKLVEEIAEKCQFHEMKTRFDAKMLGTSSYKSGTNYGFMRKGEVGNWKHWFTVAQNEMFDKYIHEQLHGSMYNFTYQISDVAFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DX59</accession>
    <name>A0ABY7DX59_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">KCNA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_008157</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF252">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="260"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="10"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR01599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="392" mass="44109" checksum="9CFD73BB0B15FC06" modified="2025-10-08" version="1">MAVSSGSRLIYAWVSIIFVCMSIFSFCAETHPYFQLPPSEVHSLRSLYKLFTLEHSKVFHEISKSDVTSLPDSNNTNSTGVNNIFSDTETETDETTIQHPALLIMDLMCVLFFTIEFLTRLVFCPKKRRFCSSLQNIIDFIAIVPDYVEFILLCFSPQVRAGGLGFVDFIFILRMLRLCRIFRLIRHVPGLWILLYTLKASFNELLLMFVFLLIGMVMFASLLHFTEGGEQFSNIPVGFWWAVVTMTTVGYGDMVPVTGFGYVIGSICAISGLLMIAFTVPIIVSNFVLYYTHVQYGLSDKDDVAGRICDVSDEVETCSFHTSCTETSEDLRKKQEAQLEKTVSNSKLVEGFDSSGDRKPVPLTSSVPVLKNVETNEKTEDIPMQHGRIAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DX87</accession>
    <name>A0ABY7DX87_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_023918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ99545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="65" mass="7818" checksum="FB077F4CD943B514" modified="2025-10-08" version="1">MLRDRIKEEEVRIQDLTTEKEDFIHELDDLRTRIYSKHGTTETLKTLKDKRKKSSMVPKDQITTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXA7</accession>
    <name>A0ABY7DXA7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="113" mass="13362" checksum="1CD3EFAEFA4DF006" modified="2025-10-08" version="1">MELIEKEVVRKLSLIGLCVKSTKRLPRRKISMRVKRPTDRMMSNRIIRRERERERERGANASSTVMQNVEKYDSPAKTVDSRKSAVSHTEQSQYEVSVFVQYEENKPEMCIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYR7</accession>
    <name>A0ABY7DYR7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF547 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361">
        <property type="entry name" value="ELECTRON CARRIER/ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361:SF3">
        <property type="entry name" value="ELECTRON CARRIER_ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF547" evidence="1">
        <location>
            <begin position="21"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="250" mass="28953" checksum="D272C364A310D7BF" modified="2025-10-08" version="1">MFKDYFENLAPQLQYVDLGMVSENEKKAFFINVYNALTIHGLVERTELPQSVLKVEQFWNTTAYNIGGLVYSLDDIEHGILRSNRSHPSSVHPTFKKGDPRLKYIVKELDPRIHFALVCGAKSCPAINVYTAMNLDRALDAATQAFCAQEVSMFTEVDEIWLSRIFQWYSQDFGNTDIDVIKWTIPYLEKGIQDRAHVLLFKLDKVAPVAIKYNEYDWTLNLPKPKYDPTEIHPNDLMEIENDNEQIQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0H9</accession>
    <name>A0ABY7E0H9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_009257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR02699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="339" mass="38036" checksum="F25361D2294CA888" modified="2025-10-08" version="1" fragment="single">DLPGTPREIRAGNVSSEDLFACDPFSRAAKSRMLNGNKSTTVRRYHQGRVRRLLEHLQYPGLVAEVRAEGVFIQLDEQGVPTRQENVDAEPPGPVKTPMDISGLSLDHVIPLAVLRFFILDDRARRLTVGTCLDLMFYFEMCQFDVDIDTAWRKWREIVLDIGGEKEGTFGIQILHSTSVVGLAKQRHSPCIGDSLFVDTKPHKMQYIHHPHAFSQVRSVGVQTNFPTTPLCNPAFRQQRQGFAFGKRQGKLSVVLSRSRFEDHPTRRCDIQKSKSSVNNDHSRFPENWQGREGVYQPAVPISGLPVTGGGPPRSNLAAPVPTACLMGQFHLQRTTFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3E5</accession>
    <name>A0ABY7E3E5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_019749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045897595" description="Ig-like domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="308"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR04380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="551" mass="61125" checksum="1DBC12EAE40D369B" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3F7</accession>
    <name>A0ABY7E3F7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDT8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_010302</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd04670">
        <property type="entry name" value="NUDIX_ASFGF2_Nudt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003293">
        <property type="entry name" value="Nudix_hydrolase6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040618">
        <property type="entry name" value="Pre-Nudix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13994:SF13">
        <property type="entry name" value="FI03680P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13994">
        <property type="entry name" value="NUDIX HYDROLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18290">
        <property type="entry name" value="Nudix_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01356">
        <property type="entry name" value="GFGPROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="62"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR03744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="208" mass="24014" checksum="CC530D02A5BA1E87" modified="2025-10-08" version="1" fragment="single">ALLRWQEEGVRGFWAKIRLEHSHLTAVFAKYGLDFHHAQPGYVIMSKWLPTTEPDMIPEYANQYLGVAGFVVNEHNQLLVIQEKYHPGTQSPKWKLPGGHAYKGEEIADAARREVREETGIEVEFVGVISFRHQLHYRYNCSDFYFICLMRPARTGQEINKCDIEIKDYPDITDANRFFTQCYLDGVVKGNMVIGATTVSSYNRKTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5W8</accession>
    <name>A0ABY7E5W8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="142" mass="16359" checksum="6E13A510D4DFD595" modified="2025-10-08" version="1">MMSSLVPGSIFSASGFNRKSTPTPPNVTPAELDNRYKRTNFNGTEWPYDSPVARAYDNSTRLRGYYTGPKKPDRYVDPERHRAKSPRFHPEWHDRCLDSSSPKFEPTVRSHLEWVNSSERPPNALIECVESIQINQNSMKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7Z5</accession>
    <name>A0ABY7E7Z5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ACT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="138" mass="15523" checksum="3B80CA1AB8A72624" modified="2025-10-08" version="1" fragment="single">MQLPDGKLVTVGNERFRCAEVLFNPSLINVEQPSISELEYNAIWKTDIHCRADRCCNLILDGIYNVSSALLQDFQSDFKKSEHLLYHRQFKSKKGVRSGSIRLSALPGFPMGHSNFHFGALLIIAAPDDCSEDVCLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E805</accession>
    <name>A0ABY7E805_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027968">
        <property type="entry name" value="JHY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15261">
        <property type="entry name" value="JHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="952" mass="109673" checksum="0EF2B6A69B470370" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E940</accession>
    <name>A0ABY7E940_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ETS1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_021914</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF289">
        <property type="entry name" value="ETS-LIKE PROTEIN POINTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="5">
        <location>
            <begin position="35"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="4">
        <location>
            <begin position="319"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR06545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="428" mass="49277" checksum="1C8ED4120CFD7461" modified="2025-10-08" version="1">MLCVCVFPDVSAATTAQVPPLTPGTTQKMSQALLESFKSFEKDQHRLNIPRDPMQWNEGQVSQWLNWAIHEFTLEGVNVANFAMCGSELCKMEKEKFLKLAPPYMGDILWEHLDILQKEVVQDRSSLVNAPPTYSEPVCMPEFSGHEDQQVFNQGQGQQFQMSESIQALNDLSPTYEDTYHSLEEIQHGGFYGDHSPTEFYTMPEQKYRPPPMKTNNMCRGQQFLPQEAHSQPHMESFFDPHHQFSQMVPNVKMELPWSQAEYPGCRDMAGTWSPTERPGMLRHGYHPLQNIGELGSPVEGKPMIQAAALAGYSGSGPIQLWQFLLEQLTDKTCQHFISWSGDGWEFKLSDPDEVARRWGIRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELWDACDIKPQKDKDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EA61</accession>
    <name>A0ABY7EA61_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UPP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF11">
        <property type="entry name" value="FI09636P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="248" mass="27694" checksum="F951842E655B66F6" modified="2025-10-08" version="1">MDIIEDNKTAVFEEGKEDALPTSNGRVKLHNARLKSIQDDHLYHIALSTGSDDLRRLFGDVKVVCFGGQATRMEKFAWFIAREFDVSDTVHNFAAGTDRYAVYKAGPVLSVSHGIGIPSLSIVFQEIVKLIYYAGCENVTFFRIGTCGGIGLEPGTGRMDGAFCEHEEEEKFLWLREIADRGVTNMEMESLGFTALCDRANIPGAVCCVTLVDRCEGDGITNNLQLLQEWQTYPQILVARYIRNRLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAU7</accession>
    <name>A0ABY7EAU7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EMIL2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_020893</name>
        <name evidence="6" type="ORF">MAR_021431</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF2">
        <property type="entry name" value="EMILIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045034254" evidence="3">
        <location>
            <begin position="21"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="4">
        <location>
            <begin position="15"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR05524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR06062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="145" mass="15952" checksum="201FFB5D3DC7525F" modified="2025-10-08" version="1">MFKIFSCVILLGFLCQIGTGLFTARKPTNLAPKNGTNVVFGTVVVNDGDRYNSTSGVFTAARGGDYLFTGALCPQRAKGFYFGITQNGVEQTRASFTETDGHVCHTFTAILRLKRHDKVALRSENDANLLNEDAARWNMFYGVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECD0</accession>
    <name>A0ABY7ECD0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MLP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_017488</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052235">
        <property type="entry name" value="Nephronectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050:SF28">
        <property type="entry name" value="UROMODULIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="AMOP" evidence="9">
        <location>
            <begin position="361"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="10">
        <location>
            <begin position="502"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="961"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1067"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1149"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1192"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1318"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1403"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="965"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR07530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1610" mass="179873" checksum="8306F69A8A7FD811" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGL6</accession>
    <name>A0ABY7EGL6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SATL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_017522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047273397" evidence="2">
        <location>
            <begin position="28"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR07564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="606" mass="66728" checksum="FFBCDE41A7F51C7F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGW3</accession>
    <name>A0ABY7EGW3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ACHA6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="2">
        <location>
            <begin position="69"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="250" mass="28331" checksum="3272AF93424F78BE" modified="2025-10-08" version="1">MSLAYKNNEVNLLKIGQTGIDFTLYQNNSLWEITSTSVYVETLATGTELQMHFILYLKRKSAYMVLNVLMPILFLSLLNALVFWLVPESGERIGYCITTLLAIAVYMTIVMDYLPQSSDPVPFISYKLVIDLISSSLIIVVVIFNMRLHNKAGDQNVPGWLRSLYRALACYNCKQKKVNPEIIQVKVAAWQKKETVENGSEEKKKIAKNDGDLIDEDGNKITWQDISAMRNQFSPELIEFGGSQNLPIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EI08</accession>
    <name>A0ABY7EI08_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">P52K-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="106" mass="12005" checksum="22EA9BD2CB4FFDAA" modified="2025-10-08" version="1">MPSPLSLESELHIWQQKWKNVESPPETLQESLKMCPMHLYLNIHTVLTVSGVFPVTSCECERSLSTLGSMKTKLRATMGQDRLSSMCLLSIHRDVKMDIEGHHGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJ26</accession>
    <name>A0ABY7EJ26_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="207" mass="22436" checksum="82E128ECB5983F22" modified="2025-10-08" version="1">MCEGKGVGQYTFSNRDAGRVVLTTGFEAGSVIDVVNMSSLSTIQSKGAILACEDIVGNRALTIIQPDGESLTCPPGDELSTHASTTHTTRPPRMDNDVEEIPISDDITALPVSILTYATTTYSTPPLTTYHEEISISARYPILSIILPIMTALLFVLLAFVCVCMCRGRCQRRNGGSIELREVVISEPLRSISEDSSIVEYSRAKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELN1</accession>
    <name>A0ABY7ELN1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="162" mass="16287" checksum="9A07438E09F8975F" modified="2025-10-08" version="1">MGNLSNRDGERGFSMANLALAGTAGFSIANLTGAGSVGFSMANLTRAGSAGSSMANLAETGTAGFSMANLTGRGAGFQHGISDGGGERGFKHGKFSVGGECEFQQGKYSGVGERRFQHGKSSGVGERGFQHSKSRGVGIAGFSIANLAGSGSRICLAMLVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENK3</accession>
    <name>A0ABY7ENK3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="71" mass="8154" checksum="50D0EB78F17D5888" modified="2025-10-08" version="1" fragment="single">GWLSRLSRSGRVGTLRGRRPSVDVLRSAEHHRDRARDLTPLQIVCIEHTSIDSTHLSTVVHRPDIWLMFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EP15</accession>
    <name>A0ABY7EP15_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="60" mass="6749" checksum="46E2327659A5AA46" modified="2025-10-08" version="1">MTSRWNRGEDTNSRIWVGEAFLMAGANRGVGENRGLCESENDCLTREESGMVIIALYYMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESS0</accession>
    <name>A0ABY7ESS0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aurora kinase</fullName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_027205</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="38"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR13025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="291" mass="33764" checksum="8714346855BBA336" modified="2025-10-08" version="1">MTICGVTMEPRVLQPVNDQNTSENAGTPKKKELTLANFDIGKPLGKGKFGNVYLAREKTSKFIVALKVLFKSQLQNSGVEHQLRREIEIQSHLQHENILRMYQWFHDKKRIFLVLEFAAKGELYKILQREKRFDEKTTAKYVYQLANALKYCHSKKVIHRDIKPENLLISLIGDLKIADFVQLSSPAVQWGQRTTLCGTLDYLPPEMIEGSFHDENVDLWSLGVLCYELLVGNPPFETESNSETYRRITRVDIRYPSYLLRHDPRKRISPDAVMTHHWIVANHTPKDPPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETH9</accession>
    <name>A0ABY7ETH9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RTTN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030791">
        <property type="entry name" value="Rotatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31691">
        <property type="entry name" value="ROTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31691:SF1">
        <property type="entry name" value="ROTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="213" mass="23426" checksum="03B4F5B28432F82F" modified="2025-10-08" version="1" fragment="single">MRLSDVDIGLDHAPECIYQRHNHTGLTAGAETTVDTIATRHTQEYSLAPSTNAPYEHAARLPDYREPPLGFFEAGQGDMGQQPTTPGPGGHPTAADLGLEGCSCFRMTLFPWLSLTPTDRHFLSSTSSSLQSREASMLVSTCEFLSDVVFQDFPAEIFLQRPNIVKNLLSLLSGPIKEGGVARLQAVRTLADYVTCLRSRIRCHQDPNFYTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETI4</accession>
    <name>A0ABY7ETI4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PGBD4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="36"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="467" mass="54508" checksum="04CEA6675EFA18DD" modified="2025-10-08" version="1">MILFQQPPNLQWKLTLIQVELVVLALLIYQELSKIIMPRDRFNLIWHYLHLTDNQQPQETPDKLRKIRPMMTYLNDKFMNAYTPYGNVTVDESMVKFKGRLGFRQYLPSKPIKWGIKLWALAESTTGYLHRFQIYTGREEGVQGKGLSHRVVHELTNHLRFSNVRVFMDNFYSSPDLFTSLLNVGIYACGTVRSNRKGLPPQLLPKIVKLPKHEFKVAQKDDVMACCWQDTKPVMVLSSFHDPDAVGTVNRRSGNSQQQRVRVPKAIEDYQRHMKGVDLFDQMVGYYMPNHRSRKWWRRLFHHMQMSAAHNAYIIARDSNPEVIQREWPQFQDFVEDLAEDLIGNYKASRAAPLTNIENLPPVPREQHEIKSKLFIRHKKRKFVPKWLQQNVKKDGMISALPPAFTAKEERQLVERLTDMASNGYGYTRPELFNLATDWGITLHRNKQCDPQFAPSGILASSEETLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVR0</accession>
    <name>A0ABY7EVR0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_026981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF3">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR12801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="215" mass="24403" checksum="5FDFC73419491409" modified="2025-10-08" version="1">MSKGSSGDGHGQSTTAGDVRARNTNPDILQNIRGTVVYFRNALYDLLAMFRCLGPPTLFMTLSADDLHWPELGMLLVAKLQTHSHSNYCMKSSKPPCRFGFPKRLCQHTVLLSHIVAVKNKGKFYDTYRPSDSLLINAYNPEILRHWRANMDIQLINDANGAAYYVCHYLCKSEPEELKCALANLINTVFKQNPDMTAFQYLWNVSLCVLKNRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWL0</accession>
    <name>A0ABY7EWL0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="171" mass="18669" checksum="807099CE8EA4025D" modified="2025-10-08" version="1">MRRKKGQFISKSNANRASIINNVNVEKKTCISVPETVPPWLEGRRVVEIGVILERLSSCSSCGNSFCINGIGETIYGLGSILHISCNTCRMVNLVPTGKRHSTSDGSAARRCFDESQISAIFAELNLPGISKTALKAREREIGPSIERVAEISCTTAIQQEMKLLQAVNNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWL9</accession>
    <name>A0ABY7EWL9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="14" mass="1678" checksum="CA59211CA51783B6" modified="2025-10-08" version="1">MYLTAFQDSLMNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZ79</accession>
    <name>A0ABY7EZ79_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="536" mass="60366" checksum="E29CE03811C1EF9F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0I9</accession>
    <name>A0ABY7F0I9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="318" mass="35309" checksum="DF5D8C10CC6745A4" modified="2025-10-08" version="1">MIDHLFRLVNNFPPRVVFVHLRALFRDMGRSGEWNPVLQTGNPASALILKKHLKAIGLEQTACNVAKKQAVPLMFDKLGALCRYLTYQIAVERDAHAKFLLLRDRAYFSLICHSGDRAGDLGQLTLDRVFELPDNQGIFISEISGKTVSLHNPKNIVVFRSKDDSICPVTHLQKYMSHAATISVDITRGYLFRLKDKFSKDISEKQVTATAMSDRLKCHLKAINLYNGESAHSSRRGCAIVLRMLGLADTSINQHIGWGSGGMLDHYARVGTLCSPNSVAATLSDAAALQPDGVSRLEVISKQFSRLEHLSKFSCDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0R2</accession>
    <name>A0ABY7F0R2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="158" mass="17672" checksum="9F4F9E8DF51576EB" modified="2025-10-08" version="1" fragment="single">LKNTIIAGSQSYETDIHTFRFPVINVLIGAGVICGLCILFVIGRWIYLKRLKVNTTDTVEIVENHSDTSSDNGVLHIATEGVQYAVVHRQAATQRIETQNPQDEECLKYAELDVKFLQAANARVPSWKKNTPTEYAEIEFFSTQGPAVEQPGYHYASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0W6</accession>
    <name>A0ABY7F0W6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027897">
        <property type="entry name" value="DUF4559"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35083">
        <property type="entry name" value="RGD1565685 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35083:SF1">
        <property type="entry name" value="RGD1565685 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15112">
        <property type="entry name" value="DUF4559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="245" mass="28236" checksum="E3C151CBBE461021" modified="2025-10-08" version="1" fragment="single">MAFYKTIVEIEEDSQYWLKYLLAPTYGLRNLAEHGSFETQRNILSSILADKGQSRVAICTMCMTANLFRCPTRGLCSHKQNCKFHNTETKQYRPCPNRICEDFRDKICELHRYGRPSWKNTRAELWCTNHFEVAKCFMAEGYEDVTSFKNLDLNGTLDLVVNCTEYESYFPLLLTYPKEILTEKPSLKRKRDEYLSNDNPPVQIALLGNEAQSMSTHCDVIDETGACPYKDLSFSTTGQAKTKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1J2</accession>
    <name>A0ABY7F1J2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046604928" evidence="1">
        <location>
            <begin position="29"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="654" mass="69154" checksum="7F37F2BF3F65CA7C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2U5</accession>
    <name>A0ABY7F2U5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24694" checksum="7AA8F6C8F0A28BA1" modified="2025-10-08" version="1">MWVDPIQPLNRGQGTLQASHQRDDLSHAMFIFQLLQKGMIFTALVVGVICCGHLVFVRRKYCRNTTTLLAVVLPGFFHLIACVKVLIIAEKNTVIRGKEGTPSVGLCLDYLMTANFKWSVSSCLAYAGILSCIITGSFFVINRVPQYSSLQVAQHSPVTLGTPGNQHIEVFLSVCQKNVYEERWAILAEYLLIYIPVIVTVLAALCMNKTKQTDYIRKVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3Y2</accession>
    <name>A0ABY7F3Y2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DZIP3-like HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="98311" checksum="BE8F043F2BB88DA7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F454</accession>
    <name>A0ABY7F454_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CALM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_031551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR16957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="178" mass="20485" checksum="E0C8B9EEB6E592EC" modified="2025-10-08" version="1">MASNKKTNQGHGETTMDKASVCSSHDVEKSFDSEIRELFRLFDTNNDRSISVQELDKAMRFLGMSPTQQQITDAMRGLDTNADGRIEFQEFYKFMQAEMTKMDEADFTNNEETVRSAFRTFDKDGNGYIDEKELRIAMKKLGEALTDKEMDDMMKQADVDGDGKINYEEFVKIWCEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4A4</accession>
    <name>A0ABY7F4A4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_031622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR17028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="142" mass="16558" checksum="F6978A6384B5C21D" modified="2025-10-08" version="1">MSQQLEDFSLFWKMIWQQKVEKIVMVTNLIEHGTPKCEQYWPNPGAGKRYGNIKVESRSEDEYAEFTRRALSVTMGTEERTLHHLHFTCWPDKAIPDDVTAVIEFRQRVLSTPNTLNGPTVVHCRKKCHSVVYTFFLLVANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5F3</accession>
    <name>A0ABY7F5F3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="527" mass="60492" checksum="1C157A45AC3F6CD0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F627</accession>
    <name>A0ABY7F627_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GIGA6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF15">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="261"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="767" mass="86760" checksum="D0BF59DFD49A66E5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F6U1</accession>
    <name>A0ABY7F6U1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="187" mass="20755" checksum="5014F768D528FCF7" modified="2025-10-08" version="1">MTAALLNQDFAIAKRILLLHHQQQDIVMSVYPENMVKRVRTSVHRRVIHVNTSIIAFPAIAGISGYPVKYHVLMGVRGTIANRKQDHACYANMGISENIATTLAPNLVDHAANSVNVPNANLDILKLMNCVKSAIHNALQMNVIRLLEDVLKVVHMDTGMIPVTESVIQNVYLAIKEMDHAYNAKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7L2</accession>
    <name>A0ABY7F7L2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR18105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR18105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="138" mass="16093" checksum="D35C78BC4BCD9832" modified="2025-10-08" version="1">MTGLGLALTVEYTNQESSFRRRNVLKEPMLQLLEVKDVVQPGKAYQVSEDSVTTLNHQGFTSEIDIDYFWNKIYIPFLTNIVVNLEDRFPDLPLLQKFEVFNTRKFFGEEPTCRGEDDIKEDKTSQDNINIRGKLHDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7P4</accession>
    <name>A0ABY7F7P4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ERIC3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_031778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048257">
        <property type="entry name" value="DUF4590"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027962">
        <property type="entry name" value="ERICH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23034">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23034:SF2">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15257">
        <property type="entry name" value="DUF4590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4590" evidence="2">
        <location>
            <begin position="214"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR17184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="401" mass="45603" checksum="B0140E8CF6A72BA2" modified="2025-10-08" version="1">MRRHLRKSGLVTRRGEIVGENQYRLNMARKEHKKHVKDLLAQAIVHKTLDLERYRQVEIKKKLEEISKIEVVRRVRSDTNGRKFDLDIRNDKLDRRTQQDASIMPLLSPKPRKTSKLDSEALQQYALRLSKSERGRDGATSPYLISAYPTPPKRERTRSARSHSGERREKDSGTVEGALMLHRQEPAMMHQGEVQTLCEITMKYHGPNLTLPRDQRDPTQEVHIEQQHCGGNTLPVFRERLQAGSTFSFVSRRHRGYPFSLTLYIDGRMDCRVSTCCEYKHGVGVKLGGKMGHFSLTGITGATPCYKCKLSCQAPPRSIKLKKGAQKKNQQPQAHEEVTVEGTPRTPIKEKKKQPKEEIAGKSDDDNYDDDFEEEEDSKASRSSSSSSKSSTSSSESGDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7W3</accession>
    <name>A0ABY7F7W3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_000130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR18292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="353" mass="39819" checksum="4AF1D3582269440A" modified="2025-10-08" version="1">MKLCDKLTTYRGNAIAHVERVTTESCRAKRCANTPVETLQTLSRSPSAAESITLSVEKLKLSDDRDKSRSSSATAPTAKRSILFEEHAYMKTKTTEVHCSLDTLEKETELKILMKTLSDIQDSHMQELDSQLSCFSGMKSFLFKKDGLSEDTFFLDAVLEMCKGCPLLAQCIFTALGKKISEEAMIATAATIYGMILHCRNKQVSGLQRLLTTVCIRYNADNKLLTHLNKVHLTLSEESKRKLIQDFGDKSENSIISAIAEGHDGKLNGDNLDIRVNTNDMRMDVTSRNKDYHFFATDFTLDRVNLDHLSKVTPNVEAVQARCFLPNDEEQHYYKKSLKILLGRELQKLDGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8Y7</accession>
    <name>A0ABY7F8Y7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_032081</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="46"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR17487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="346" mass="38606" checksum="32F855FD39601D5F" modified="2025-10-08" version="1">MASNNTTEQSAFMFRDGYDIPVYGLANGKFYYVHIPAIVCIAVSLSCALAAITLSFRRKSYRTFFSKWSKSERLVVYLSTFDALFSVSHLPDHLQIVITKDHVRPRELCTIYGFMLVVFFAAQMLIVNVVAIDAFVMMYFNKKIYFGKYDSGLLVLTFGVPFVGAVVAAVYGQFGPMGSACFYDAVKGNVANLSFTTIPLPIVMTVNITLYILTWFKIRNQVNNLKNTLGPLTRTTNAPCKAARNMSMFVLTAFVQWWSVAVFGVWALVVNNPAQIPEILHDIGVIFTNLGGIMNLIIYLKLKRTDLQRQTNELRAASSNTTIKTLSTGSNQSKDSLSDCLTNMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9C3</accession>
    <name>A0ABY7F9C3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTPRA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="218"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="371"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR17622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="469" mass="53729" checksum="8B607B5D5282FABE" modified="2025-10-08" version="1">MVLQNTADQMALYYCMFAGGTGIGGKDVVSSSFHVLARQGNTRRCNCDDRVQTACSEYAEYTEWTNCCALQGQYQFLHTAVVYSLTFDCKQIKGENFNEYMNRHSTQVLNTQFKFSPCGFLVSYVCWQWKCIPEHLFLLSPVKDRGSLYQIVAFHVGLFKTLLISKCISPLALVLFEVLRNIKECNRRQFFINASSTKTMLKYASLKCLKYHLQQTLETRSKDETEAVERNKQHLSKNRANADIPGKLQTYITEVFVMKKRYLVAQTPLPETVIDFLTLAVQERCSCIVSFEADMEKQKNIGIYYPAANQEVLKKGTLQVSCSREENKTFYAERTLTIQHKGTSTYRTIPHLQFTDWDEMENKPRSTTNFLSFLNVIDDVMKQQDDGPILVHCFDGAGKSGLFCVVSLLLHKMAVEHEVSVLNAVRKVKTTRRLAIPNQEQFVFCHGCVSEYLRSFDVYANFNDETGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9V9</accession>
    <name>A0ABY7F9V9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_000230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46726">
        <property type="entry name" value="TWO PORE CHANNEL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46726:SF1">
        <property type="entry name" value="TWO-PORE CALCIUM CHANNEL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="578"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="179"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="525"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="609"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="811"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR18392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="898" mass="103649" checksum="F971510C97CA0984" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEH2</accession>
    <name>A0ABY7FEH2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_002416</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR20578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="458" mass="49888" checksum="4E8746AB7C13C5AB" modified="2025-10-08" version="1" fragment="single">MPWNFGNLGGMQDFLKKKACRYLLQHYLGQFLKQKLSLDQLSLDLYNGQGKITDLNLDVQAINEDLGSLAVPVELVDGFVECIAVSIPWSSLINDNTCLEVTGLELTLQPKQREDNGMMAGDMLSSMHSSMTTSLQLARECLESDSGTSQQPQQPIEGVQKFALMIDSVLSKIRVKLLNTVIRLEHQPGGTMFQSAMTSLASGASVYKSTIQSPNQSNLHKSTQSGLGTTPLSEPVHLATITGRQEIKLEIMCQFGGIHVLGASSRPMDVVDQARVERELQYQLQSGRVTSNNLASLQEYSLHGEDDDQFQSMMGRCQGPGSDMDSSFTSNYSTSSARTTSTAFSGQEPTSPINHYHVRVGFISLTLLHTTPGPPTDQPALDGMKEVATTFFQRVAGVTAAGILLGRPLTVECTQKSALRQVSTSVHVSLGVAEVVETLYGPRDQKPAHQHSEIEVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFK0</accession>
    <name>A0ABY7FFK0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_001605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="63138" checksum="99784A1BC937C55F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGJ5</accession>
    <name>A0ABY7FGJ5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_015272</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF67">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Macro" evidence="6">
        <location>
            <begin position="570"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR21298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1055" mass="120021" checksum="4BCAC103EC8E2AC6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGM2</accession>
    <name>A0ABY7FGM2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Y1252-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_015236</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF67">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Macro" evidence="7">
        <location>
            <begin position="315"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR21262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="442" mass="49368" checksum="8B4460B64FF3A950" modified="2025-10-08" version="1">MQVISVSDIYNLQILQNRNTNEKLLDFLRTHIDVIPHTHVVFRSDEKEVFFGCKDEQSLRIFVSNLQNLVFKREFNIADGECREMIKALQTFGQMYILCSDQETVHMLCTQRVIKQLDEHMQCIFQVRLLPLQVEYFASFGKIKVQELGLENGLQIYLNKGNKTLTFRGKRCDIKAMDDRLKTYFQLKKIKIALPRNILPTFEETAVAAASEQQCCYSINWRSSAEKGPGNRLIASLKSKDGNGVTLIQGRLFDLDVDAVVILANTSMSPRTAIAEEDIEPHMLEVHIRNGTLIPDQKADISVNTTGKSLQLEKGGALSRSIVLAAGVQLQDELSKEYPGGLNEGQIAVTSSGKLSRNGDIKAMVKTCLAEADKLQGKSIALPPFGTGRHGYPIRKTALAMFEAIDEFSEESAFISAQSKESSSPDRKKINNAQFINSTGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FH48</accession>
    <name>A0ABY7FH48_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="93" mass="10282" checksum="07C9254AFDBFE92A" modified="2025-10-08" version="1">MKPSDGRCETSTGPDDQYGIAYDYRDQMAQATCTALLDTTSAHVYAVRRTCSNLTVPCAEVCSSLRYFPSCQPYAVFTLIAKKSAIVVLFIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FH85</accession>
    <name>A0ABY7FH85_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TNR16-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_002062</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052491">
        <property type="entry name" value="TNFRSF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46330:SF6">
        <property type="entry name" value="HEMATOPOIETIC DEATH RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46330">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00020">
        <property type="entry name" value="TNFR_c6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="7">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="9">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="9">
        <location>
            <begin position="86"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="7">
        <location>
            <begin position="86"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="9">
        <location>
            <begin position="127"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="7">
        <location>
            <begin position="127"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR20224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="212" mass="24005" checksum="D4E2EFB949E5D24F" modified="2025-10-08" version="1">MKICTVLDHCIVFVWIYLINIQSVVGVLPYSISQKTSGYRSKGCPAGKYYDEETYERGKCRKCVVCPKGYTEFSSCSTTTNRSCKPCKIGTTFSDNRGGICRNCTDCERGQFVRRQCLPYRDARCKNCPNGTYSLDGKGFGCKYCSVCKEHEEEVSPCTSLQNRECSLKEDYTLGNTNHWNTGPEYNKDFSFSTRLVLLSLLIAMFPKLFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FI37</accession>
    <name>A0ABY7FI37_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FBXL2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="391" mass="43389" checksum="AC1418D009C57820" modified="2025-10-08" version="1">MVKTLSDISLNFIQNNLHKLDDVCKLPTVYKELLLEQIAWHDLLTESYVPHMTKLFSKSLTKINFYKCEQISDNLLKSIAASECKLESLSIIKCFGITGVDTLAGRNRQIKELYLWGVAEHTHRSRSHEERMHAYEVLDTKLNQMCDECLVAVASYCPNMRILNLHGSSKISGQALTKILVECLQRLRRLKCVKLCGILEHIGAGLTLFDISGSVSACLTDKALEAVTQHCSSLEALHLSLIPNMTGTGLLPLLRDPVRATRLKGLAIGMKKLSYEVLSEVVAQCSNLERLHLSGVTCVDDEILTTLAQNCPGLSRLLTDASIFCLANCCPQLEEIYMNGCANISPVAVRYLKDCTIPRLFVGHATPNAAPDQLMARNLDTGQFCRVDKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FI43</accession>
    <name>A0ABY7FI43_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoglycerate mutase</fullName>
            <ecNumber evidence="5">5.4.2.11</ecNumber>
            <ecNumber evidence="5">5.4.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_014803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17765"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58248"/>
            <dbReference type="EC" id="5.4.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="5"/>
    <dbReference type="EC" id="5.4.2.4" evidence="5"/>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010713">
        <property type="entry name" value="PRK14115.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR20829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="356" mass="40718" checksum="8A910FB6FEDB0A1E" modified="2025-10-08" version="1">MMLPVGKIQDVLENCPGWRPNVIQQPLTGNTVSKQEHNHHHDKHTQLVQLKISDIQKNMVFLAVFYPYSQAGIGFIQFFEDFVGEVFLHDNALVQDQLYKLYLVRGQSLGQNTLKALCRIVLVRHGESEYNKENRFCGWYDADLSPTGLEEAKNAGKMLKEKNYTFDIAYTSVLKRALKTLFMIQDEMDLHWIPVVRHWRLNERHYGGLQGLNKSETAAKHGEAQVKIWRRSYDTPPPALEPSDPRSATQEVKYAQYDEAVVPLCECLKDTVERVLPYWHDSGQQVLISAHGNSLRALIKYLDKVSDDAITELNVPTGIPLVYELDANMKPVKHYYLADEAQVKAAMEKLAVVTNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FI56</accession>
    <name>A0ABY7FI56_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NGB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_015791</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="6">
        <location>
            <begin position="44"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR21817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="547" mass="65382" checksum="F9188422ABF41F00" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJA9</accession>
    <name>A0ABY7FJA9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_016269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR22295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="43799" checksum="5F9D0E36902C3E71" modified="2025-10-08" version="1">MCSTSIILVFLITEYLIISSIIGISVAIGQDESISDGHSGDSPPALDLALSGTSVAFEKDGAEDIDYSGEQSGETATIELDGEDGMTSQGDSTSTSEAAVPGCPNGTFGVNCDQTCSCNQTNTDICDKVDGNCQCNPSWKGTSCEEDVDESKDYSMIWYIGGGIGGAIVLNVGIVCIVFFVRRRNRANDSSRYKDDSLGFGKHQFKKSLSVTEGQAKEYQENNANNSPKNHNDPFGLEIHKLESFLPVSEVKPKEDQENSAINNPKNLNDPCGLEIHKREFFLPFKPKNDQENNPNDGSKTMNDICGGEKHELDSVLPLAEVQPKEDQKTCANDDSMNLNDICDMQLHLFESFLPLPEAEVQATEGKTTSDYDAPKLESFLPIAEDQTTAREDDQKSSGDPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKV6</accession>
    <name>A0ABY7FKV6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="582" mass="64219" checksum="3D53AD9F6A177AD7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPJ0</accession>
    <name>A0ABY7FPJ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TRPM3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_036616</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF12">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="10">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR22947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="225" mass="25999" checksum="1E5141E3D03F8C11" modified="2025-10-08" version="1" fragment="single">YDCADDKALWIDGGQPRCPTELGKIVVPILLGIYMIIANVLLLNLLIAMFSYTFSSVQDKSDIHWCYQRCLLVEEFGNKPFLVPPLNVLYHVTLLLKYLFKMIQCKNHYEWDKHKHDSRQTSRWESMIVNAYQQQTLQQKDDSTQSRVNQTNTTLEEVLLSVKELKQHSQAAAQEIKDMKAKMSRLVTSNANANERTEMCGHELTSCYPGTSIAQIWVPDGKRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FR12</accession>
    <name>A0ABY7FR12_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_038319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12671" checksum="F37078D4ACDBE966" modified="2025-10-08" version="1">MPAQPPRQQPRSRPTSSRPAEKFIPEHEIEIPGNGSLHDFTADDMSTFLRYLGVDERIVAHVHKKGLDGYKFSKLKDSDLEVLGMKNPVICHFRDRSIKEKGGKKKLPFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FR78</accession>
    <name>A0ABY7FR78_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="69" mass="7588" checksum="F33829DBB035D5BD" modified="2025-10-08" version="1">MVGSCTVSPLEFVEPDLSSLPAPRPMSPEATPNDKRDSLSEKNRADSAIFTGTKSFLVFKEEKKEGKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FR83</accession>
    <name>A0ABY7FR83_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAIRB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_036895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="2">
        <location>
            <begin position="131"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR23226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="253" mass="28390" checksum="1D8504C342457ECB" modified="2025-10-08" version="1">MIKTQIDTLNTCLLVTANVLFHFYQCSNLTSLEKVSTAPRLNDRPRTGGRPNREPREPREDNRPPRRREENANQNTERSERVSSGFQRPERTEGGGFAQRDDGPRDGFGRGMRGGRGRGTRGGRGRGGFGGKREFERHSGSDRTSGVKPTEKREGSGSHNWGTVKDDIDWRADDQVLYALNHLENIFVLNARKNGYLFLAASHQSSVACWSIVSVLHASFIYELYDKCDNVGVPMTDNDLSGMPKPTSIKRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRV1</accession>
    <name>A0ABY7FRV1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_037698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR24029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="554" mass="62112" checksum="AB022A5541092687" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FST7</accession>
    <name>A0ABY7FST7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cysteine-rich DPF motif domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_010982</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDPF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042426">
        <property type="entry name" value="CDPF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018785">
        <property type="entry name" value="CDPF1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31849:SF1">
        <property type="entry name" value="CYSTEINE-RICH DPF MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31849">
        <property type="entry name" value="CYSTEINE-RICH PDF MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10170">
        <property type="entry name" value="C6_DPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01995">
        <property type="entry name" value="UPF0595"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine-rich DPF motif" evidence="3">
        <location>
            <begin position="33"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR25278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="132" mass="14893" checksum="6CBD2E614678F0E5" modified="2025-10-08" version="1">MVLSCKAGRKLEINHHITQIMSIGEGTDQVKEFLCSICSLKVNYDFFGTKPPFAKSILLMEDSYVMKDPFTSEIGIISLGSHCSLCTKSVCASQDCSIFYTKRFCMSCVNANLEEFPFEIQQEIKNRKLKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUI2</accession>
    <name>A0ABY7FUI2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MTR1A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_011554</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF75">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="56"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR25850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="334" mass="37977" checksum="FD8DC655A4E763FB" modified="2025-10-08" version="1">MNKTNDSIATNNYSVVDNIPSGVVLYGRHEFLQTMPELAVPCIIVLGFASIVGTLGNLLILFVIATKKKLRNVESIFIVNLAISDLYVTVVADPMSLIGKLEGEQFFDRYTGLCQAVGSICTISCVTSLTTIMMMSINRYFYICSHDLYTRLFSRWNTLCVCLSLYLLGGILVFLNLADVGDHGFDQKSLECIWDRMASYPYTVVYSVVMVWIPALITITAYIRIYMFVRSRRRKLQASVNSDRATSSNHNVKSLHLAKTLGIIYAVFISCWSPYALVLILDTRDTFPHELHVFCTVFAHLHPSLNWLIYYLTNKKFEEAYNETFAWLKNVVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0B9</accession>
    <name>A0ABY7G0B9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_038475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="87" mass="10007" checksum="6CBB90F1ACF33DE1" modified="2025-10-08" version="1">MANNHFEPYEKEWGNGTRDRKDRHSLGKRSSVSSCKGRYGRSNSRARKKQTSEESCIANLKMILQCYNVFILNVWSAPISSITIRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1G3</accession>
    <name>A0ABY7G1G3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="42412" checksum="B2EFD5DB159FD86D" modified="2025-10-08" version="1">MVNTGNLKTKMMRGKISLIVKVCLIVFGFSLILGYTQWNPSIDTDNKKRQEYKIIQNQGMSKMIPVNASSSSMTTLSPIAQYDLRILLIVYNRAKSMLRLLNSINEASFDGDKVKVEVWIDRSKEGVVDPLTVETAEGFVFKHGDYEVIKHSQHVGIYGQWLGTWKPRVNSSEIAVILEDDLTVSPHFYKYLKLVHNKYDSIPEINGFALQGISIKHAIGHSHKMVEAPEDCLVYLYPVLGTWGFSPSRDNWIHFLEWFSQVNQDKTFQPYIPGNVMTEWFKTFQSQGKAGGVWSIWHIYHSWKFKEYTLYPNFKGHKGLTTNWKEPGLHYTKSASKPSNELLMEWKPDYENLPDQQKHLDLKGVVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G203</accession>
    <name>A0ABY7G203_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="165" mass="19330" checksum="42344B9870C96525" modified="2025-10-08" version="1">MNCAKDGIGVKNLKIHVLRSLVMNIVQSMLRIGFDLRVDTSVPLEPTYREAAKRRLQQVHENLFEGIEQRRRMIYNLCMARAYDDEADGRFFRYLVEARYAGEDGAFFLTDIQNINAYHDFLKKKKRHDKMKIVLLEIVDIVCVFVCVCVCVRVYKFLALTFPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2Q0</accession>
    <name>A0ABY7G2Q0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="748" mass="84685" checksum="1A956BAD67997DEA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2W0</accession>
    <name>A0ABY7G2W0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF8">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="120" mass="14254" checksum="E55A2C148B1D2D07" modified="2025-10-08" version="1">MDDDDEDVYQKNLFDRYSARPDSLEDICLPQQTATKITLKDGQGFMIKRNKPAIIRTHQWSVKKQPEPYYHAKLLLYHPWRNETNDLLTKRNTNSPGKVFYKTPYCLNTLQTNLLMCWKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6R5</accession>
    <name>A0ABY7G6R5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CDC20-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_014430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="236"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="384"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR28726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="446" mass="48849" checksum="BAD74B7FF1D7455A" modified="2025-10-08" version="1">MSHFKFDNLVTELTRLDAPLQSGPAMRFNRKSASGLAVSLGSPRSARTPNVPDSARFIPSRSNTDFDLAGYTMKPRQEAEDEENQSPTRVEYQRQLGAAMNIPEDQRILSFKDNKPKPAEGHTNNLQVIYSKNKAWGPGQGPKRVIPKVPERILDAPELLDDYYLNLLDWSSNNHVAVALGAAVFIWDASSGSIVQLTEMDTPSEYVSAVKWITQGSILAVGNIVGRAYPEEDPDGSRSGAIHHSDVRVANHNIGTLANHTQDVCGLAWSPDGRHLASGGNDNVLNVWPNTLGGDVTPLLTLTHHQAAVKALSWCPWQQNILASGGGTADRHIRLWNVNTGCPLTSVCAVLWNQEHNELVSGHGFSQNQLSIWRYPDLAKVADLEGHKARVLNLSMSPDSTMVASAAADETLRIWNCFAVDQKRKKAPPKLAGQTETIILKASRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G712</accession>
    <name>A0ABY7G712_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17872" checksum="FBEA7731F9D17B02" modified="2025-10-08" version="1">MNRYVPIIQKITKMLGASLKVLVLVAVLISVTGGLSSRGSSGGGHVYDDSPQARGLFKDADTDNNEYLTYGEFFNIFRRFDNNSDGEVTSVEFLNEWLNERIGTPEQAMYLFTIIDLNKNLVLHISEEVPSLFVWFDFNSDMMITDGEFVVQWVKIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G718</accession>
    <name>A0ABY7G718_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosidase II subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_014535</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="13">
        <location>
            <begin position="153"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="12">
        <location>
            <begin position="444"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="14">
        <location>
            <begin position="720"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR28831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="939" mass="107011" checksum="794A9CB46F4D1D40" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GA78</accession>
    <name>A0ABY7GA78_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFC" evidence="2">
        <location>
            <begin position="26"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR30006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="364" mass="37778" checksum="8C924FDDDBA1E8BB" modified="2025-10-08" version="1">MKKTTYALCHYKGLYYRQGESWYDGCGLQCRCEDALNHYYQCTDRCPKYTNVPSTCTFVADPKDPQCCRVPQCQNAGGNDPRDACCQVLKCEAAQTFGTCQDKVNCQSYGNYVCGQQYEVWARENCGKFCGYCGGGTNPYLATAPPSGACVDAIPNCAQYDVSVCTDAQYRPWAVANCPKHCNMCGGTGTGTGTGTGTGTGTSTGTGTGTGTGTGTGTITATGSDGVITGSGTAAPGTGTGTGTGTGTGSGYVGYSGGCVYKGRYYGAGDHWYDGCDYNCTCENGQTGFYRCGDRCPTYNLAAGCVLRTVAEQCCGVPDCTGATGTGTGTMTDVWCGTFPRPATGTLQPPESAARLPTALQMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAP7</accession>
    <name>A0ABY7GAP7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_003724</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">Golgi stack membrane</location>
            <topology evidence="12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="80"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="224"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR30156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="424" mass="49411" checksum="6738382209010278" modified="2025-10-08" version="1">MGFVLFDMLSNCYRDVTHFKLLNKCNKKVFATIIVLSTLILCLGMHNMVYDNISHPGEVTKTDFSEHIRHWNVSYWKPKQTKRILMWTPFFSTNTSKAAEGFNKGFKLCNKKCIATDVKDEISVSDAVIFHASDIWKHRGIVTNILDQGIEFPAVHKPEQVWVFYSMEPVTKMYGTIKPNTFNWTMYLRRESTILTSYSAYRKKLPEEMAKPSTLTEEIPNYFKTKTKFAATVVSNCYPPFQRYRVIEELQKHVDLNYYGRCSGKSPLPAEFIKNDVREELLKDFKFYIALENSICRDYISEKFWNALDRRQIPVIAAPKYNLELLPEHSYLNLFDFENVKDLAEKMEEIGNNETLYNSFFDWTSTWSRRTGSSECALCEELHKNKTAQVYDIDAWLNDDLCQKPTVLGIANNFVSSVLHDFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBY5</accession>
    <name>A0ABY7GBY5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_033163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF444">
        <property type="entry name" value="PROTEIN SCABROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="653"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR30621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="862" mass="99590" checksum="7786AEBB48A05E68" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GD90</accession>
    <name>A0ABY7GD90_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MEC2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_033765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd03403">
        <property type="entry name" value="SPFH_stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="54"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR31223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="293" mass="32147" checksum="D652EE366E93DEAB" modified="2025-10-08" version="1">MAEENGETFKDNNSPLGYVTGGVDSDDDLVCCGYILWALSMLVIICTLPFSLCLCIKVVQEYERAVIFRLGRLLSGGAKGPGLFFIVPCIDSYTKVDLRTVSFDVPPQEVLTKDSVTVAVDAVVYYRVYNANTSITNVEDANRSTRLLAATTLRNVLGTKNLSEILADREAISHQMQTSLDEATDPWGVKVERVEVKDVRLPVQLQRAMAAEAEAAREARAKVIAAEGEQKASRALKEAADVISESPAAIQLRYLQTLNTISAEKNSTIIFPLPIELFSSFTRRTPQSYSPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GEW6</accession>
    <name>A0ABY7GEW6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="89" mass="9432" checksum="0714646C835727FE" modified="2025-10-08" version="1">MHTQECCEHGLQFTNATVGAQQTFTNPGMQYSKYQPYPAGPYYLAAPSHQAVGLATDMVGVSVQSTLAGTSGQPISPPPYTEATPNVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GF15</accession>
    <name>A0ABY7GF15_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045622750" evidence="1">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="116" mass="12266" checksum="7A30CA0003BBE8B9" modified="2025-10-08" version="1">MKLLFVCLMCLAIIVEGQLGGRNICRHGTAGSCLGYTNQQCPRNSVCRRVSGTYGVCCRLPNSNPGGVCCRHGQRGSCGGLFGLRCPRGTTCQCFPNPPYPDAAGTCCISRPGNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GG53</accession>
    <name>A0ABY7GG53_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="181" mass="21135" checksum="85207F6D9F7794D6" modified="2025-10-08" version="1">MELDYVRGLKGGKILSKYKLGSEVSKLTVENTIYRNRRQREVERYRAHVLEFLMRDDNSRCNPGKQDKLKINGETRQTRILTDYLKNLHLKFLSENPEVKLSLASFCRLRPAHIKLTKFISRSCCLCTKHQTFALCTQALRKCGIDVPLNPEKCIEDAANIEKNERKHQPMLHMGNGREFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D788</accession>
    <name>A0ABY7D788_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_006010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046133323" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="115"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ93539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="185" mass="20836" checksum="57948CB299E3B2D1" modified="2025-10-08" version="1">MVQITNLLLLQLILLLRTVKCDLLFKQDTNYRNTFCRDKYLDKNKKASKTMCAAECRMEPECVAFFYDVRSNCYVTTQTLIDAVGCVYLEGTFYRSETGSVTTTVATSSTTTESCTYTRMDGTRSRGRDIHTVESTSSSDPCINLCTSDPLCAGVNFNPGRQRCKTRTEAALTSHNGLIWYEKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAK3</accession>
    <name>A0ABY7DAK3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="170" mass="21194" checksum="7A6F7753B7C9FBBE" modified="2025-10-08" version="1" fragment="single">QGSSRHKEDLRHKEDIRHKEDLRQKLDIRHKEDIRHKEDIRHKLDIRHNEYIRHKLGIEHMLDIEHQKYIEHKLDIEHMLDIEHKIDIRHKEDIEHKHKEDIQHKFGSEHMLDIEHMLDLRHKLDIEHKLDIRHKLDIEHMLGIEHREDIEHKIDIRHKEDIEHKLGIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DB65</accession>
    <name>A0ABY7DB65_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_006493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF14">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="280"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="813"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ94022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="899" mass="103045" checksum="12F1928A12FDBAF4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DB93</accession>
    <name>A0ABY7DB93_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SVP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="151" mass="16846" checksum="85DD6AA490A19F03" modified="2025-10-08" version="1">MTEHTDWTEQTDWTRHTEGTRQTEMTEHTDWTEYTDWTSTLIGQSTLIGLYTLKGLDRLNGQGTLNELDTLNGLDTLNELDTLNGQDTLNGLDTLNELDTLNGQGTLNGLDTLNELDTLNGQDTLNGLDTLNELNTLNGQGTLNELDTRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCR2</accession>
    <name>A0ABY7DCR2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">TSSK1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_028147</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF102">
        <property type="entry name" value="TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAQ95457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="282" mass="32527" checksum="E08B961D0D21274C" modified="2025-10-08" version="1">MEKTTQRKFIRMADILTSKGYRIGQEIGEGTYSKVRTVEKTSDGNTYAVKIVDRAKVRKDYLKKFMPRELEIIPLLKHENVINTFEIIQTRDFVFQVMEYAEKGDVLQLIHRQGFLPEEKCKNIFRDISKGIKYMHDLNIAHRDLKCENILIFHDNRAAVSDFGFSRAFDSTSNVITCQTFCGSSAYASPELLRGIPYDPKLNDAWSLGIILFTMLNGSMPFPDGNVTRMVQKQLSRDYQFSERLQDKVSAGPRQTVFRTLDPNINSRPTCADILEMDWLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DD96</accession>
    <name>A0ABY7DD96_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="469" mass="52429" checksum="9EA423A0432AFBB5" modified="2025-10-08" version="1">MHGILLGITKKLLSFWLDNKHSSEMYYIGKRVNEVDNKLMQITPPHSISRLPRKLSTTMKHWKASELRAWLLFYSLPCLKDILPDIYLKHYSLLVEAVFILLTEGISHEDLHRADQILHMFLKTAPALYHDNIMGLNMHNLLHLTTCVRNWGPLWAWSCFSFESFNGQIKKTVHGTGNVCLQIFWALMAQKYVEQSFSEINDTKTLEFVQTLSNKTQHDETKQCIVRKKYTFSKGMSFPEQIRNQLESLAGTSDISKYMKVKKCVVNGKTIYSKSCMKVKSRNSYTVLVSDTSNSARYIEIQYFIIETSTGKVYAIGKELAITSHVLQANAPHLKVVEVTREEKVEKATNIQSILVSFTVNDHHIISDIPNSVEAGSVSMVTAGSVSMITAGSVLIITAGSVSMVTAGSVSMITAGSVLIITAGSVSMVTAGSVLIVKAGSASMVTAGFVAEAEEKYWSVNLWDFWFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFW3</accession>
    <name>A0ABY7DFW3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TMM26-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_028201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168">
        <property type="entry name" value="TMEM26 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ95511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="564" mass="63369" checksum="A0BDBAA290CFD385" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGE6</accession>
    <name>A0ABY7DGE6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CDHR1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_029437</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF263">
        <property type="entry name" value="CADHERIN-RELATED FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046526348" evidence="9">
        <location>
            <begin position="20"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="28"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="175"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAQ96747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="474" mass="52690" checksum="F240899C103A2F4D" modified="2025-10-08" version="1">MELPLLWVLLLLFFRECESEPHPPVIVDNTDAAVVVSEDTKIGTVLWTLKAMDEDGDDVIIGYPEYEAESKTLIDVLVDLVISDVNDEVPVFQNLPYRLQIPEPITQSDKDAVVFTNTFSMDPKTASIFLKAPLDYEKMQFYQFKIIAVDGYGLNSSEVLTIRILDIQDTPPEVQGTPYVVTVQENSPLGKHFFTCRAIDGDRGIPNEVAFSFSTETPCQSLFAINETSGEITVSGDVDRDFGDVMEHGGVCNMEIFVREIEQPAHAQFGLTESRAALSVFVTDENDNAPSISADSFRAYIDNTAELNYPIQFENDTEIFIEDKDQGSSGILELVLRGEDGDMTYDFEPIPSVIASRGAPLIALKSPDLIKRRGNITLKLYAIERDTAERNSATAVIHIRVTPGSKKQPHRSPECVHWQRTSCTEHGSAYWAPASGAKWRTDRRGLDIHGDAAGEGYQDCLQCVKALLPREVMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHX2</accession>
    <name>A0ABY7DHX2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MARCO-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1106">
        <property type="entry name" value="VIKING, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="416" mass="43841" checksum="C18D1A15ED7DBEEE" modified="2025-10-08" version="1">MVEVKRNKEKGTPGHQGPPGRIGSRGQKGNKGTSGNPGLRGPPGPYGHPGWPGPPGFVGFPGEIGEKGFPGYDGIPGIIGDVSWAGVNGKHGFRGPPGYLGHVGFIGMPGPPGIKGNVGMTGDWGMPGIQGIAGVPGDVGFYGEAGPMGEPGFRGPEGEMGLKGPNGERGEQGDIGQWGSVGSPGSMYDPYAAMFGAASAAFDYDPFKDVNCSETDDGQSTCSFESGPPAEAIGKSSKMAFPVYMHPPPGAQVVTVAAGPMIGKAPFIYGPPSLGTKVQGQSRVDISDEDLVRDMGYDSEDGDILTEKDYIKLLKKEEGGLIDDQFNNGTITSTPVMFKDQFNNETTKSAPDMFEDQFNNETTTSAPEMFEDQFNNETTTHAPEMFEDQLNNGTTTIAPDMYEDSSEEYSDKHSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJQ7</accession>
    <name>A0ABY7DJQ7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="119"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="481" mass="56037" checksum="440AEC625D5A2E24" modified="2025-10-08" version="1">MKKNENFVYKNLYAERKAPGTLYQPMASSKPNFAVGDSVRITKKKKTFEKGYTPRWTEEVFTVSEIQYTNPVTYKIKDYNKEEIQVTFYEQELQKTDQEIFRIERVIQKKSKKALVKWLDPDPGAKVTLDKLSWFMPHVLPADAEKFQLYKTIQSKVTLPVGYRMRQCENITVPQSTRFTWRLGVKSSPEKPRWIIVGFQTEKDNDQTKNPAIFDNVNVSNLNVTLNSTSYPAVDYNISFIKQQFSRVYGDAAAFRSKFFHMHELVSNPNITPSDYKDLYPLFVFDVSKQSEKLKTSVTDIQVKAQFNANVPADTQAFALVISDKMLSFQSDGEKMSVIYLGSLPNQKNLGNDLKKMCFRYKMTTKLSVLRQILKDNKIEGYFRCNKPQLIELLEKRGLLPEEVMESELKTIRNNPKHVTLTDVTLDKEYKYPSIYKAALFIKKSPRTITFWNNRVWNKKYLVKVEEGEDKDFVPLRAKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKE5</accession>
    <name>A0ABY7DKE5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HP1B3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_029830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="2">
        <location>
            <begin position="277"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="590" mass="65449" checksum="E93A6E13065EC638" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLD0</accession>
    <name>A0ABY7DLD0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F1142-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_022371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM114 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007998">
        <property type="entry name" value="DUF719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12842">
        <property type="entry name" value="FI01459P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12842:SF6">
        <property type="entry name" value="FI01459P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05334">
        <property type="entry name" value="DUF719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="290"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="308"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ97998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="677" mass="73666" checksum="34E90AB40AFD14B8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMA0</accession>
    <name>A0ABY7DMA0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CAN8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_028815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00214">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033883">
        <property type="entry name" value="C2_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF433">
        <property type="entry name" value="CALPAIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="7">
        <location>
            <begin position="24"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="539"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ96125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="641" mass="73609" checksum="D2D08DFB40EF87CE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMB2</accession>
    <name>A0ABY7DMB2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZFN2B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_022119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057357">
        <property type="entry name" value="Znf-C2H2_ZFAND2A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF20">
        <property type="entry name" value="ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25403">
        <property type="entry name" value="zf-C2H2_ZFAND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="85"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="215"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ97746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="265" mass="30240" checksum="BDB6ED20DC36E209" modified="2025-10-08" version="1">MELPHLGTHCHQKDCKQLDFLPMNNDHIHYATHSCPESYKKDNQVPVCPLCNKPIPLKKGEVPDVVVGRHIDSDCQSDPAKERRKVYTNKCSMKGCKVKEMIPVKCDKCQQNYCLRHRFEDDHQMAALFRSKPTSSGSSKTKANNQAPQNRAQNNLTRGLGSELNRQREERIRQQQQQQRQDVQRSQTQAEKQLRAAQAGLSEEELMARAIQQSLSETQQPANTNQGEGISQEEEDRLLAQALAASEEEARRQRNNTQEEVIIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQA9</accession>
    <name>A0ABY7DQA9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FMAR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_023270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="39"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAQ98897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="374" mass="43109" checksum="DE698758B13A6796" modified="2025-10-08" version="1">MESDNVTMGDLLKKEEHFVLYERIKIWYTPFLCFFGICGNIISIAVLRKGTISSTHILLISLAVIDTLVLTFSPLKQWIMHLMQIDVRQTTEVVCKLDMFLTYLLVQLSPWVLVMITVERAYSVIKPHLVRVVFTRRRTLISLAVCIVCLSVVDSHLLYGYKLIFIKEAGDIHCQPRSEAYKNVMFNIFMKIDFAFAFAIPCCCLLTGNLIIIAKLRFSRHMQATTCNERGMSTAKRRRNRLSHSLSQWTRTTVVINVFFVMLMLPSVAFGIGQVYWFPIEEITPAKRANIHLISEITFMLMYTNNAINFVLYILLGSKFRSDLMNMCFSKRDHLRSTNGNLRTNASCDNDVRYTCVTHCCIVYACAGYLQFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DR39</accession>
    <name>A0ABY7DR39_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47202:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47202">
        <property type="entry name" value="HISTIDINE-RICH GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="44416" checksum="A5D898B1D49F049D" modified="2025-10-08" version="1" fragment="single">YVFHSIVFHSIVFHSIVFHCIVFHSIVFHSIVFHSIVFHSIVFHSIVFHSIVFHSIVFHSIVFHSIVFHSIVFHSIVFHSIVFHSIVLYSIVFHSIVFHSIVFHSIVFHSIVFHSIVVHSIVFHSIVFHILCSIALCSIVFHSIVFHSIVFHSIVFHSIVFHSIVFHSSVFIVFHSIVFHSMCSIALCSIVFHSIVFHSIVFHCIVFHSIVLHNIMFHSIVFHSIVFHSIVFHSIVFHSIVFHSIVFHSIVFHSIVFHNIVFHNIVIVFHSIVFHSIVFHSIVFHSSMFIVFHSIVFHSIVFHSIVFHSIVFHSIVFHSIVFHSIVFHSIVFHSIVFHSIVFYSFVFHSIVFHSIVFHSIVFHCIVFHNIVFHSIVFHSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTG9</accession>
    <name>A0ABY7DTG9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">dCMP deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_024350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAQ99977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="209" mass="23265" checksum="DBB7814235717755" modified="2025-10-08" version="1">MDDGSASKSQASSGRFTNKREGYLEWPDYFMAIAFLSAQRSKDPRTQVGACIVNEEKKIVGIGYNGMPNGCSDDLMPWAREADSILDTKQLYVCHAELNAVLNKNSADVKNCTIYVALFPCNECAKVVIQSSIKEVVYYSDKYKDRPAFMAAKRMFDQAGVTYRQYQPSKKKIVIDFSLIEAMSDCVIADMDSLKINAPTVDSQPDSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTJ6</accession>
    <name>A0ABY7DTJ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SYNC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_025435</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR01063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="244"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR01063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="511" mass="58474" checksum="9706EC1BA563714C" modified="2025-10-08" version="1">MAQVSEELAEMSFGEVYTSEKLGSDETGDGTAEKPFKSVLEALRQTDGKEPLPNIFVDGKEEGKKYEPLAKAQMKKQKKIWQSEANKAADKAKRDDEDAERREKNLEEARKVVLTQDPALPTPKQIKIRAGVKTRSVRVKVYGWVHRLRRQGKNLMFLVLRDGTGFLQCVLSDILCQSYDALTLSTEAAVCLFGEINVVPEGKTLVGSSPPGGADNLLNEEAHVDVQLDNRHMMIRGENTTKVLKMRSVVMHCFREHYFDRGYYEVTPPTLVQTQVEGGSTLFKLPYFGEEAYLTQSSQLYLETAIPAMGDVFCIASSYRAETSRTRRHLSEYTHIEGECSFISFDNLLERLEDLVCDVVDRVLKSPYANIVYELNPDIPEAPERKMTDQIGEPILLCKFPTEIKSFYMLRCEEDRRLTESVDLLMPSVGEIIGGSMRIWQYEELMEGFKREGIDPTNYYWYTDQRKYGTCPHGGYGLGLERFLCWILNRYHIREVCLYPRFVDRCRPRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTN7</accession>
    <name>A0ABY7DTN7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="73" mass="8277" checksum="56DBE13865CE47AA" modified="2025-10-08" version="1">MAALADGNRESEIFNHPGSKTKSYVWKVFGFQKIALNLPPTKDNLNMNIAICRLCKKTYKNTVKQLLSSNIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUJ3</accession>
    <name>A0ABY7DUJ3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">THSD4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_024926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF316">
        <property type="entry name" value="LONELY HEART, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047548743" evidence="6">
        <location>
            <begin position="25"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="7">
        <location>
            <begin position="649"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR00554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="692" mass="76194" checksum="4961F45A1D5D9D43" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E044</accession>
    <name>A0ABY7E044_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DYHC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="317" mass="37725" checksum="59DF7AE3051DA89B" modified="2025-10-08" version="1" fragment="single">MHGLVFHCVRHFLHVCGYGLVYHCVRHFLHVCGYRLVYHCVRHFLHVCGYRLVFHCVRHFLHVCGYGLVFHCVRHFLHGCGYGLVFHCVRHILHDCGYRLVFHCVRHILHDCGYRLVFHCVPHFLHVCGYGLLFHCVAHFLHYFTVFAISCISLDIWVNISLCSPFLACLWIWVSISLCSRFLACLWIWVSISLCSPFLAYLWIFGLIYHCVRHFLHVCGYGLVYHCVRHFLHFCGYGLVYHCVRHFLHFCGYGLVYHCVRHFLHFCGYGLVFHCVRDFLHFCGYRLVFHCVRHFLHVCGYGSIFHFVRDFLHFCGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2M9</accession>
    <name>A0ABY7E2M9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="101" mass="11068" checksum="E3024DD14DE70E2D" modified="2025-10-08" version="1">MNPVYMCFVIIYLDIVFMAIGSDSARKQKNDVCNIAAAAFVVADFVAGYDKVISSLADIFCQAEKESITANKKGEEKRIAKPFNVLLGRGKTVTFKPLSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3F2</accession>
    <name>A0ABY7E3F2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">COQ5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_008219</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with PYURF; the interaction is direct, stabilizes COQ5 protein and associates PYURF with COQ enzyme complex.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48424">
        <property type="entry name" value="DYNEIN LIGHT CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48424:SF3">
        <property type="entry name" value="DYNEIN LIGHT CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR01661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="308" mass="34383" checksum="D5D86723CB56245F" modified="2025-10-08" version="1">MAAPITKCQSRGFICLRRISRVFSTHLNQKNNKHSEASDRKTTHFGFETVTEEEKEEKVYEVFKNVAEKYDLMNDAMSVGVHRLWKDHFIRRMAPLPGTKLLDVAGGTGDIAFRFLNYVKSRDDNSPQDVFTDLSSSSESSDENGLPSHNLRSHDCHVTVCDINQSMLEVGQGRAAEAGITSGGRFMCLEFSEVPNSLIRSVYDEYSFQVIPVLGQVLASDWSSYQYLVENFGNKLEKQDSDLSQVEIDEMLGLVGDVAAEVSANNCVPGWVVLFVKFLLDEGGNVLLNVVLLKGLGRAVYSILLHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E564</accession>
    <name>A0ABY7E564_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PRAX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_020534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35245">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35245:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="297"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR05165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1631" mass="184232" checksum="8EAE7A559F5EF3F5" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E659</accession>
    <name>A0ABY7E659_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MOT14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_019800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF306">
        <property type="entry name" value="RE01051P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="34"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR04431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="575" mass="62857" checksum="C4EFB27D8213B171" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6N3</accession>
    <name>A0ABY7E6N3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="191" mass="21929" checksum="3DDAD5A6BF3B949B" modified="2025-10-08" version="1">MTCSQQLLKLILDMCRNAGLYAIMAVECQDCSSKEQRSLCVRSMSPHKALGIHSGNTLLVYDKQVHQRNSNCRVVHDPFGRMCFRYRAISRSVLCETRWTARSDALSTFKNAFPVVVYTLEELQDDHDFGATSNTVTVAPVNRRNYNSLLETNMTCCREMFLGEIRRWKARCPARELDQVPSRLLETLDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E714</accession>
    <name>A0ABY7E714_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TUTLB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_019588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="20"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR04219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="226" mass="25337" checksum="D188D67B4F85E3FB" modified="2025-10-08" version="1" fragment="single">MALTRIPKTVLTSPGKRPHTPSNLQLNQKATVDTIYIEWTPGFDGGLPQTFHVEFMEVGFSVWRDKGVIAGYTNHTIAGLNPNTLYEIKVYSTNDHGRSTASEAITVTTLKMPETLETGLVIPAAVGGGILTVATVIVVLVILRRKSPGHCIFLRKRDVQDEQSVSGTDHPGYNEEQTYKRVFMTTAESKMEQIDPTTRMCIPRWMGQVQNPMYTTRMIRKRIPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E794</accession>
    <name>A0ABY7E794_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_019997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045189949" evidence="2">
        <location>
            <begin position="23"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR04628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="137" mass="15258" checksum="3695C06F7A55606D" modified="2025-10-08" version="1">MRLFSVGCVCVFALGLLGLVQSFGEMGGGYGYGGYTFGKQPQVFLFILIINLLFPNNSKGKKDMDGDHYSKEENHDSYDMYADPYPTGDPYGDTASHDSYAMYADPYPTGDSYDPYGDTTYDGPHWVVVPHGVDYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E912</accession>
    <name>A0ABY7E912_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="310" mass="34943" checksum="4875C02BE9BE767E" modified="2025-10-08" version="1" fragment="single">MLYDQLNPAQFQINQAQTKTRLPINGENGVQVESTVRSKRPIEDVGSPSITRSGKRFREKECTGSESWSISDKQREMIKDTLHEAHALYRRSRISQDESPFEEADVPILSDKLAESLYIIDDRIYGCGFRNSTLEVFVNVSQGVMSDKEVEKMGLKVGTAAKEFDVFETEIKVGRYEQVNYSSCQVGTRIKNDVGQFATLGGFARKEGELHVLLARHFADPAHVRSIHYVDGRLGNILLARVLSGSHRGIYDISVAKVSPNISANTMFRDSEGQPMSSSLMDMSTVNRRDLCERHVHFWADEQQPRVGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E916</accession>
    <name>A0ABY7E916_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL17m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L17, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_020775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR05406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="142" mass="16723" checksum="4F43272C0F8DBA9B" modified="2025-10-08" version="1">MLRIQVKRRPRKLKGVLIGSGSGPTERIKYLQYKVNRLIRDERIEGREDRIHEIRGYAEQLLNLAIQNGDSHKPTMIMATNWLKEKELVYKLFQVLAPRYENYTTAFTTVHRLPANYPSTGLYQAVTHILRLFHIKETNLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9V7</accession>
    <name>A0ABY7E9V7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (uracil(54)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_010484</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>uridine(54) in tRNA + S-adenosyl-L-methionine = 5-methyluridine(54) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:42713"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="2191"/>
            <end position="2254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="75"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="228"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="415"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="685"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1365"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1777"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1914"/>
            <end position="1944"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="778"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1027"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1234"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1404"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1485"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1956"/>
            <end position="1984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="685"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1787"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1919"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="2220"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="2270"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR03926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2337" mass="263122" checksum="8CBF4FF3CEDAE671" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAC0</accession>
    <name>A0ABY7EAC0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DPO3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_020950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the exonuclease superfamily. TREX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd06127">
        <property type="entry name" value="DEDDh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057617">
        <property type="entry name" value="PML_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040393">
        <property type="entry name" value="TREX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058:SF22">
        <property type="entry name" value="EXODEOXYRIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058">
        <property type="entry name" value="THREE PRIME REPAIR EXONUCLEASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25244">
        <property type="entry name" value="PML_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="144"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR05581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="424" mass="46818" checksum="D103DF01710206AD" modified="2025-10-08" version="1" fragment="single">LETSNDKNHIVKNFGNELYKLKSKHKSLSNNNIAHIQKCFSYGISQNKGSTHGIKTSLDALPSHMFNEHSSCSPTLCKSLRDENYRQAHILQGTELRKDFQNVIHGGHANDTVGVSDIEIEHIEDIPPCPAECSETPHAYGQDDVIVFDLETTGLESILLSGTNSSIVQIAALHVSSGQHLNLFVKPKCGYIPTTASNITGLEFHDGVLYQHCKEVTSVAASEALLAFKRWLEAFGSHILLVAHNVMFDARLLVAKYQEEGITVPETIGFADSLRLFRTVYPGRQNYRLASLVHDIAGVDFGVHDASEDVYALSSILQLQTNLDKLSNYATTVSSVKFKLQELNNEKLYKGSYTTFVESKIISKAQATRLSRSGISIDHLKKVYSRSGLDGMQAVLKDRGAGKFYTKLASALDAVFSENKINLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EB46</accession>
    <name>A0ABY7EB46_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrator complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_021396</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Integrator subunit 10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026164">
        <property type="entry name" value="Int_cplx_su10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16055">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16055:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21045">
        <property type="entry name" value="INT10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR06027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="687" mass="77781" checksum="F4685AFCF6134837" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EB69</accession>
    <name>A0ABY7EB69_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C1QT3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_019775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF33">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047312797" evidence="4">
        <location>
            <begin position="21"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="104"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR04406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="280" mass="30796" checksum="96B85A2FAB44ECC5" modified="2025-10-08" version="1">MKALLLILLFLIYAISMTYGKGDGEQRRDKTRHSGRRQVSEVGDDITSGHCELEITCKGDTTSRTPVRLPIRGPRGPAGRPGEKGPSGEPGIPGKQGVPGKSATANNQVAFFVGLGENLGPIDANTDLIMDKVVTNVGDAYEPMTGKFTAPFSGTYHFTVVVAAQGRQKAAVMLMEDGKMTLTVWAESVPYWATSSNTALLTLHRDQQVWLVRLQRAPYLHGYMYSSFSGYMLFSENPDVRNRTENELPVLNEMVETTEINTKKNTKQKSNILPEVEVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBI4</accession>
    <name>A0ABY7EBI4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_021908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR06539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="28566" checksum="524827739B066832" modified="2025-10-08" version="1">MGVLTIAGRIVLVVLNIILIIVSLLLIVFGFILKFGNEIVRPYIKETLESIENAAKNVYSDSDFNTEAFDIGAMLSDLTVVMIVVGVALLAFSFYAIVLIVLLLAQLKDNLNKGLDKTFDKYEGLKSKTTTSVGWNWAMQYYDCCGGRSYKDFENKGTWKVNDATGQSFVLLTPVACCKALPGDGAGIDDCAGDTDNAAFDTIAEISANSNAEKGCTEAIFKKVITDNNVGFLTVIGIFFACQIALIIFAMLIFKDRGITGGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EC99</accession>
    <name>A0ABY7EC99_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MRP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_021707</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="21"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="185"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR06338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="424" mass="47364" checksum="73C25A21E9C7CD0A" modified="2025-10-08" version="1">MFGHPIACALRVVLMYVPFRVFQRFYIPTSRQLKRIESTTRSPIYSHFGESIAGASSIRGYRVEQRFMYESKEKVDKNMVFYFAGIASNRWLGFRLEVLGNLIVLAAAIFAVVKDGNTGGLVGLSISYALQVTGALNFLVRNTSDVETNVVSVERVREYTEEPTEAEWVLHFKRPSSDWPDQGNVRFNNYSTRYRDGLDLVLRGISCDIRGGERVGIVGRTGAGKSSLTVALFRLIEAAGGNIVIDGQRISDLGLHDLRSKLTILPQDPVLFSGTLRMNLDPFDQYTDNQVWVALEHSHLKAFVTGLPDGLEHECGEGGQNLSVGQRQLVCLARTLLRKTKVLILDEATAAVDMETDDLIQNTIREEFRGCTILTIAHRLNTIMDYDKILVLDQGLIKEFDSPENLLADTTTVFYGMARAANLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDP9</accession>
    <name>A0ABY7EDP9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CE126-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_017247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028257">
        <property type="entry name" value="CEP126"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31191">
        <property type="entry name" value="CENTROSOMAL PROTEIN CEP126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31191:SF4">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 126 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15352">
        <property type="entry name" value="K1377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="646"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="732"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="879"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="933"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="975"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="566"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR07289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1184" mass="131261" checksum="30AC44EE09C511D0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHA2</accession>
    <name>A0ABY7EHA2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RSU1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_021905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="3">
        <location>
            <begin position="12"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR06536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="177" mass="19923" checksum="4A3E6FC4EF1AEBEA" modified="2025-10-08" version="1">MNRLSVLPRGFGAFPVIEVLDLTYNNLNENSLPSNFFNLDSLRALYLGDNDFETIPPEIGRLKNLIILVLRENDLVSLPKEIGDLIRLRELLIQGNRLTVLPPELGNLDLVGSRQVFRGENNPWVTPIADQYQVGVSHVFDYIRSETYKFLYGRHLAAGAPPPPKVADKSKKISRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJQ8</accession>
    <name>A0ABY7EJQ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BAAT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2240">
        <property type="entry name" value="Acyl-CoA thioester hydrolase/BAAT N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006862">
        <property type="entry name" value="Thio_Ohase/aa_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042490">
        <property type="entry name" value="Thio_Ohase/BAAT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824:SF4">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04775">
        <property type="entry name" value="Bile_Hydr_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="245" mass="26993" checksum="994BD48C23C8DB96" modified="2025-10-08" version="1" fragment="single">MLKSVRRLAVLSSHVQNVNRNMCLSGATATSARAPIIFVHPKFCLVDEKITIRLTGLASNQIVTFVADVRENGSVFESRCVYRADDSGVVDNCTSESLDGTFKGVEQMGLFWSLKSVGARAAMRLVKKDVTRPMEFTIRVFDGNQAEAPEVLSDPLTKTVVRRTFMAPHVKRLPLRDGRFRGTVFLPEGTGPFPALIDMFGGLVSQVETRAALLASHGYATLSLAYLYSEGLPQMLMDVDIDYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EL68</accession>
    <name>A0ABY7EL68_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RADI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_019082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13194">
        <property type="entry name" value="FERM_C_ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011259">
        <property type="entry name" value="ERM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041789">
        <property type="entry name" value="ERM_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046810">
        <property type="entry name" value="ERM_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008954">
        <property type="entry name" value="Moesin_tail_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00769">
        <property type="entry name" value="ERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20492">
        <property type="entry name" value="ERM_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48678">
        <property type="entry name" value="Moesin tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="6">
        <location>
            <begin position="222"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="765"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="796"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="769"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR09124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="910" mass="105992" checksum="A0A688C8F98FD235" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELG0</accession>
    <name>A0ABY7ELG0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="654" mass="76357" checksum="69AE049C2C6CECC2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELK8</accession>
    <name>A0ABY7ELK8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="143" mass="15597" checksum="DA10BF22FC414A72" modified="2025-10-08" version="1">MHAAQRARATATNLQQKQINVIERPANSPDLNPIEIIECVGTRSGPTSTIIQLKYKLGSKGTEPLGRPCGRSSNDCIRSDGIKCENVICCDGWPSCNEKFCVCETAKGYKYDDALEGCNHTGVYQHELSKDCNNSAEEMANLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EM14</accession>
    <name>A0ABY7EM14_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045661961" evidence="1">
        <location>
            <begin position="18"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="170" mass="18488" checksum="5A3549C1C76EADBD" modified="2025-10-08" version="1">MWRLFAAVCALVAGTAAFLEQISSDCTCPGEIAAIKDELMKIRGNMSMSSSQAALISQLQANLTTLQQTVRTYIFFLTITSSDIHKASFRLVKNGHRILNVNSIPTTAHNHTIPETNTHVVTVNMHVGDKVWAVNQGGFDAHEGLTGNLLTSFSGHLLQPHFRSTSPTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMB3</accession>
    <name>A0ABY7EMB3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Fumarylacetoacetase</fullName>
            <ecNumber evidence="4 12">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_036194</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="4 12"/>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="14">
        <location>
            <begin position="26"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="13">
        <location>
            <begin position="127"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR11118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="371" mass="40857" checksum="F967AA994D354003" modified="2025-10-08" version="1">MNNSESSNFDKMSFIPVSPESHFPIQNLPYGVFSTADNPQQRIGVAIGDQILDLGVVKSLFEGPSALNAFMGLGRAAWSEARQTIQNLLSADTPTLRDNASLRERAIVPQSSATMHVPARIGDYTDFYSSKNHAFNVAQPPVFTACKLFDFELEMAFLTGPATKLGEPIPMDKVEDHIFGMVLMNDWSARDIQKWEYVPLGPFLGKNFGTTVSPWVVTMDALKPFVTKNMPQDPKPLPYLTHEDDYNFDISLEVAIMCDGLSSPATICRSNFSNMYWTMKQQLAHHTVTGCNINPGDLMGSGTISGEMEDSFGSMLELCWKGTKTIELENGVTRKFLKDGDEVIMTGFCNGNGYKVGFGTCVGKVLPALPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EML4</accession>
    <name>A0ABY7EML4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="672" mass="75461" checksum="61B0E2F025CF9FDC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMX3</accession>
    <name>A0ABY7EMX3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="209" mass="23123" checksum="890A63BB6F7945C0" modified="2025-10-08" version="1" fragment="single">MGASHKRRRSGHRCWDPVTRGGGRDTDAGTQSQEVEVGTQMLGPSHKRWRSGHRCWDPVTRGGGRDTDAGTQSQEVEVGTQMLGPSHKRWRSGHRCWDPVTRGEGHGTDAGTQSHEEESQEEEVRAQMLGPSHMRRRSEHRCCDPVTRGGGQGTDAGTQSQEEEVRGQMLGPSHKRRRSGHRCWDPVTRGGGQSTDAGTQSQEEEVRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EN87</accession>
    <name>A0ABY7EN87_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="93" mass="10843" checksum="EA8FC90B8E7DB7F6" modified="2025-10-08" version="1">MDEQGIFSTADAIHVRCVRFCFMQLIQQELDLVRTEWNTHYIRRQTREGTPCGKPDILYLCPELYGNFDYKFPVDGQTASAWVLIATFHLALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERD2</accession>
    <name>A0ABY7ERD2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MATH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="43317" checksum="5E1202C86B6940C6" modified="2025-10-08" version="1">MAKLQRFLKLNDRFDSQVFTFVLPAKVATYDNPDAYTKDVVYGYHKWTVSFIRTNVHLGCFLKLQTAGNGMKCQIDFSFTLLNREHFTRNETFIEKSCIFTPESNQHGRKTFICLNDLLDREFAQVTGNYLIELEIRKINCNFECSIRLPKKQHHNRLQTYDTKLESSYFTYGLFDWSLSLSQNEATMQQDEFLTTYAIIGESDGFQSEELDQLVDIKGNGDLYVVNGSLQQLAKRRSSLKVKVRMVSVVSISEVTLNVSTKGKTRAHLYDKDKQAWLMEADTSGNTISFRLYYTDITHVPRKNSRYVCWNLLVLTRYIPDHKVKTNYGPFSRYYIQQDLDEGHHITTSIPIDDPRPLITPLMTRTSYRSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETG3</accession>
    <name>A0ABY7ETG3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Regulator of microtubule dynamics protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein FAM82B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_026186</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049039">
        <property type="entry name" value="RMD1-3_a_helical_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF16">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21033">
        <property type="entry name" value="RMD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR12006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="144" mass="16556" checksum="CEB89F39B2384546" modified="2025-10-08" version="1">MDVNPGDSGMLFYWTTLGSLRGRSRESRMPSKSRNILWCFTMADLKWYERTVASALFATPPSSTYDEALQYFLKAEEAEPNFYSMNLLMLGKTYLKLQDGKMAYQYLSRCRDYPMNTPDDRRANAEAKQLLAMLTSGAGRKTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUL2</accession>
    <name>A0ABY7EUL2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="398" mass="46815" checksum="2E0835A6BAD58F5C" modified="2025-10-08" version="1" fragment="single">EDQHVKESNWFRESDKYGSHYVARFPHYQQAGAALSTLIVDIKLGCSMDTPNQSGRQHRVSAVRRDLIEANEQLDSVNRRVDLMQQGLSPVPDKIDYVEHEMDAKAQKLAEIEERNKIHSAKLKLLQNEIKYEKMRGDMLMDHYKLRGDNTGVYDQSPRDDYFLDSYRDGQNTDRGNYLTQTGPPPPSPRKSQTNTPYLPENTDQQRNGNRSGQVSPRKTQYDERPLEADPRHRQNPDVHQTDQRKPNFDYEDMMRERQKHVYGYHDSTAINPHLWENKPKHRKYPWYDHETYTQPGGFLFIRFDDSGYDIMNNALKIFVYEMSQPNKQQNWNLSRRQTHPDAKMTENAVATFWFNRKEGAEGFFENGHRNQLREPCFPTPNGYEAFYVPLLSPPPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUN1</accession>
    <name>A0ABY7EUN1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19484" checksum="EEBE32E3FADE3F1B" modified="2025-10-08" version="1" fragment="single">MADGAALANIDPDRMEKHPGARLVRITEEFYEGALDIARKNFMLEEPVNKAVGMQWTDELRELWLSSLRLHLSIAAVTEVDGDIMAFRTTRITKKTDFVDPETFQNQGLKRLFLIFNHCDQKADFFNRFGVTEAFHFYGLGCADKYQQQGLASKLFKAAIDMVRYLDIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVW3</accession>
    <name>A0ABY7EVW3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="185" mass="20425" checksum="55C8F4B6ED724E59" modified="2025-10-08" version="1" fragment="single">FHADVLLAVSLPSGKIGNTKATEALVPVIGTAYGMLMKQRYHELSAVQKMVSIVLANEQTHQKVVFFNVSVLTFQFLMEILLFSGLYDRLQPIGVSLSHQGMLGAMSAISGSFNEELINAIKDGKKFRILGDNVNFHMGVDQARKSIRKVGHMQHWFGSAAILQNIFNMNNPSMTFGKSPHLASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZP3</accession>
    <name>A0ABY7EZP3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">DNLI3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_004544</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd07967">
        <property type="entry name" value="OBF_DNA_ligase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00347">
        <property type="entry name" value="ZF_PARP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="13">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="14">
        <location>
            <begin position="378"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="15">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="101"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="575"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR14439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="676" mass="74727" checksum="8A27FCD8248D1244" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F025</accession>
    <name>A0ABY7F025_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inhibitor of growth protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_004789</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15585">
        <property type="entry name" value="PHD_ING3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042020">
        <property type="entry name" value="ING3_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="8">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="557"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR14684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="617" mass="69623" checksum="E9DBA93599B76771" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0M7</accession>
    <name>A0ABY7F0M7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IS21 family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11320" checksum="353C487F6797016B" modified="2025-10-08" version="1" fragment="single">INDYLKKQTPRRTVECYIQQRKESSTQQRQAAAQRIETQNPEDDECLTYAELDVKFLQAANARVPSRKMNTPTEYADIEFFSTQGLAVEQPGYHYASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F153</accession>
    <name>A0ABY7F153_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="35" mass="4240" checksum="67FA6DA24F4A8EAB" modified="2025-10-08" version="1">MRIYHQEEAKMNPTQHWQLRARPSTKFPSRSQDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F190</accession>
    <name>A0ABY7F190_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="194" mass="21387" checksum="1018C2902A721DD4" modified="2025-10-08" version="1">MSSIKQDMSQNSHSISNITDAIRTHIRRESLTSFGRRSFASGADLQLKNAHFESVSAAVVHLFQGKPLGENDLAALQESVREVLKTDAGPLVFDFYKTQDLTIRQITLLEFRNTVLLKVPFKVTTCESDSDDDISDRSDVTPGSKGHKHLSPLLSGVSHRPLGKRTSGLLPNPLLASVKEQDRGTIRRYSIATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2Z6</accession>
    <name>A0ABY7F2Z6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045583557" description="EGF-like domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22451" checksum="52BC5E3826EEF103" modified="2025-10-08" version="1" fragment="single">MFQESTYWLLAVAVVMSMSYVSVEGTPGSNCTGNAKSCADNETCSDPTCVTRGSCTWGNLGDKGVCDNTTGKCACTTGYSWEAEKCKANGYNHTCSNENDCQSGNLGDKGVCDNTTKMCDCNDSYSWKGDNCTANGYNDACNTTPDCQLGSLGENGTCNIATKMCHCKDGFFWEVDMCKANELCQHLFVILCFNLRQLRNNETRAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4I7</accession>
    <name>A0ABY7F4I7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="1">2.7.1.150</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_031269</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.150" evidence="1"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd03334">
        <property type="entry name" value="Fab1_TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15725">
        <property type="entry name" value="FYVE_PIKfyve_Fab1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043548">
        <property type="entry name" value="PIKfyve"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46715">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46715:SF1">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE zinc finger" evidence="7">
        <location>
            <begin position="166"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="6">
        <location>
            <begin position="332"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="8">
        <location>
            <begin position="2149"/>
            <end position="2305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="822"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="905"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1589"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1670"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2110"/>
            <end position="2140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="833"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="846"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="905"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="921"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="981"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="991"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1024"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1038"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1068"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1680"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1694"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2130"/>
            <end position="2140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR16675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2382" mass="269589" checksum="F990B2727BF7D3DE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F577</accession>
    <name>A0ABY7F577_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MRC2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_030457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="129"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR15863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="248" mass="28824" checksum="4CC910DA9002610D" modified="2025-10-08" version="1" fragment="single">MICERFGAFLAEIDDPVENDFLQRQVDSRKVNFWVGGADTENEAEWMWMSSQRPIQYTHWAPGEPNSYHNSDENCMDLRPRQAGWNDERCSLVQQYVCENNEPMLASLKQFKFITGYSFTGCRSGWMNHGTSCYHFSHDQESWIAAVTICERMGGRLVEVNDVNEFNFLQSYVNMFKHNYWVGGTDLENEGEWVWLESDKPMTGGYSNWEPGEPNSSGDEDCTDMRPGHHGWNDEKCWVNLNYVCEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5A9</accession>
    <name>A0ABY7F5A9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphofructokinase</fullName>
            <ecNumber evidence="4">2.7.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_031934</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="4"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="15">
        <location>
            <begin position="66"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="15">
        <location>
            <begin position="219"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR17340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="565" mass="61991" checksum="F6AB9C9A245E9C48" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8G5</accession>
    <name>A0ABY7F8G5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_000316</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14046">
        <property type="entry name" value="STKc_EIF2AK4_GCN2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016255">
        <property type="entry name" value="Gcn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000660">
        <property type="entry name" value="Ser/Thr_PK_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="13">
        <location>
            <begin position="12"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="566"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="183"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="639"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="639"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR18478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1437" mass="163363" checksum="05B66036927CDC05" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAI7</accession>
    <name>A0ABY7FAI7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FBX11-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_000958</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd19676">
        <property type="entry name" value="UBR-box_UBR6_FBXO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006633">
        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047504">
        <property type="entry name" value="FBXO11_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051550">
        <property type="entry name" value="SCF-Subunits/Alg-Epimerases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990">
        <property type="entry name" value="F-BOX ONLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990:SF20">
        <property type="entry name" value="F-BOX ONLY PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="9">
        <location>
            <begin position="653"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="7">
        <location>
            <begin position="653"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR19120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="747" mass="83827" checksum="FE696C5AA7FE624C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBR0</accession>
    <name>A0ABY7FBR0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ASPP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_000067</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047163">
        <property type="entry name" value="ASPP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24131:SF10">
        <property type="entry name" value="ANKYRIN-REPEAT, SH3-DOMAIN, AND PROLINE-RICH-REGION CONTAINING PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24131">
        <property type="entry name" value="APOPTOSIS-STIMULATING OF P53 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0728">SH3 domain</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="858"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="891"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="957"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="258"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="320"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="619"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="42"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="619"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR18229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1033" mass="114217" checksum="52E57234E79BBB0F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCC6</accession>
    <name>A0ABY7FCC6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ERH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the E(R) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2260.10">
        <property type="entry name" value="Enhancer of rudimentary"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035912">
        <property type="entry name" value="EHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000781">
        <property type="entry name" value="ERH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12373">
        <property type="entry name" value="ENHANCER OF RUDIMENTARY ERH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12373:SF0">
        <property type="entry name" value="ENHANCER OF RUDIMENTARY HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01133">
        <property type="entry name" value="ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143875">
        <property type="entry name" value="ERH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01290">
        <property type="entry name" value="ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="73" mass="8783" checksum="13A2B463B46D2593" modified="2025-10-08" version="1">MYGICKIYEEHLKRHNPDCPSITYDISQLFDFIDQLMDLSCLVFQKNLGMYIPHNKDWLKEKIYIMLRKQAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCJ1</accession>
    <name>A0ABY7FCJ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPRY3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_001160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="582" mass="65321" checksum="7E8EF5F1309974F1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCU8</accession>
    <name>A0ABY7FCU8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Epidermal growth factor receptor-like transmembrane-juxtamembrane segment domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_031705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049328">
        <property type="entry name" value="TM_ErbB1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21314">
        <property type="entry name" value="TM_ErbB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Epidermal growth factor receptor-like transmembrane-juxtamembrane segment" evidence="5">
        <location>
            <begin position="159"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR17111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="242" mass="26889" checksum="3AFBA9F6E8316891" modified="2025-10-08" version="1">MVLFKATCASCSGRCQCCVTDRCEDYKGEDQVCVDGCKDDCTPCEQSCLANTCEQPNGICTYGCRERYWGHNCNNSCHPTCKTCLRENGICSQCVNNSLTSVGNYCARTCSDTCVNKECDVMTGRCLRGCVRNFYADMCDIECPATTTCKPESSSYGGIIGGTVGGAIAMFCVIAAIHIVLFLRRRRQKKRNSSERNRELTLHSPDPYAIEPEMQYQELSVKRLSENQDETYTDLQEATTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FD20</accession>
    <name>A0ABY7FD20_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CALM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_001881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR20043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="168" mass="19241" checksum="7BF9E31FCA1986C9" modified="2025-10-08" version="1">MSDTLTEDQIHEFREAFSLFDKDGDGMITTQELGIVMKSLGQKPTDNDLKDMINEVDIDGNGTIDFAEFLTMMANKMKDGDQEEELREAFRVFDKDGNGQISAAELRHVMANLGEKLTDEEVDEMIKEADMDGDGQVNYEEAMMLMNTICKRDHMEVRMFMYSVREII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FE00</accession>
    <name>A0ABY7FE00_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SOS1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_000791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd22914">
        <property type="entry name" value="HFD_SOS1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22915">
        <property type="entry name" value="HFD_SOS1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="335"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="573"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="7">
        <location>
            <begin position="755"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="893"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1141"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1174"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1243"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1381"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1263"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1291"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1308"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1330"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1390"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1412"/>
            <end position="1421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR18953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1421" mass="162289" checksum="5A9E8F758773884D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FE89</accession>
    <name>A0ABY7FE89_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SHOC2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_002316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF46">
        <property type="entry name" value="LEUCINE RICH REPEAT-CONTAINING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="3">
        <location>
            <begin position="45"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR20478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="233" mass="26159" checksum="23F9E84256F126F7" modified="2025-10-08" version="1" fragment="single">QQRISLFFQRYYSQEWFSGERVHVPCVSCGGLHSCPSRLGFVGSQLTCLNLNGNHLQSIPAEIGCLRGLQVLSLEKNQLTELPETLGSLTELHCLDISHNTFKHIPSFISKLVRLEELHLSHNVIQLIPPEISRLKLLLILDIRLSFLPCRLGLVSSISRLEVIDNQLSYLPYTLSNLQGSILLKDMLQNAGCCSICQSPVFEVHEAEIVPVTFNPYSFTVPLLKQVCSQHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEW7</accession>
    <name>A0ABY7FEW7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ASIC2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_001380</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF300">
        <property type="entry name" value="PICKPOCKET PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="789"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR19542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="899" mass="103848" checksum="0745BA9DD650D9D2" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFH4</accession>
    <name>A0ABY7FFH4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S46A3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_002180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR20342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="198" mass="21821" checksum="22E430ECF3DA884E" modified="2025-10-08" version="1">MFIPESFTSDKRDTDESVCEKLAKSFRLFFGTSNTGRRWLYNVLMVIFLLSLFSMFGRSSVEPLYQLDDPFCWTPEKLGYYSSAKNLLQNACGMGLIKVMQMAMSDEAIAMMACVTFGVLIGFPGPLVIPVCRALMSKLTLPGQQGAIFSAIASMETIVSTGGSVAGNEIYSATLGYYRGFVFFVFSGCNFICFILMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIS0</accession>
    <name>A0ABY7FIS0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TENX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="23"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="198" mass="22930" checksum="5CB3C8B98F2A2550" modified="2025-10-08" version="1">MGTNSHAWSGWRESLSMTEMKIRRIPSTGKVCAGRVHRQDAVYGQSYTFFFSRDISRSRRIGAGSRRVSASDFYKTWDEYKHGFGDLDGNFWLGNDKIVSLCNDEQFELRIDMELGDDTRYAQYSSFSVEDESQNYRLHVMDSVVLQGIVWRFTITMSFQQTTETTMLVRETVQRYLREHGGSLIVNNDKALEDRIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJ91</accession>
    <name>A0ABY7FJ91_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LAMA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="557" mass="64518" checksum="09CD1631030F9411" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKU2</accession>
    <name>A0ABY7FKU2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPR3B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_016176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF48">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="214"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR22202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="367" mass="41149" checksum="A39234933174E8B3" modified="2025-10-08" version="1">MELVGYVQLLMLAVQTSEYQRACKMPVDFTSYLLSASPPATKLDLLSYAFSQEASRNWQQQQQQQQQQVDKAENEKNDSSVEKIDNELSKLNLTNEHVRNGFKNLKPIIIRKDDLDSDGEWSDTSSGPNSGPNSGRVTPTSPCSPKSNKKVSFADHRGYALATVRIMTEPSDHPPKLAEDVFKTITNGAVAAVSGLPPFKLNFTQPASDYMAFRDKVGKSFVSLENVILRDYNVLGTIKVKNICFDKRVFFHMTKDNWKSSQDLEAKYVQPFGGNLVHNLDTFSFEFDIDPQTDGHRTIEFAVCFETPGQQYWDSNGGANYGIVPTDFNAVSSPDPLPTSTQPSLARRDSWTDYGCWHHVNTAAPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKZ5</accession>
    <name>A0ABY7FKZ5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ZFYV1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_001724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15734">
        <property type="entry name" value="FYVE_ZFYV1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042427">
        <property type="entry name" value="ZFYV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46624">
        <property type="entry name" value="AGAP002036-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46624:SF4">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="598"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="5">
        <location>
            <begin position="602"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="704"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR19886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="766" mass="87324" checksum="F7F1C5F3D3627237" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLM8</accession>
    <name>A0ABY7FLM8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR23118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="133" mass="14946" checksum="FBFCD793E5F29B6C" modified="2025-10-08" version="1" fragment="single">QTQQTERENWSQEKEVWSRRNRLRPHSTVLLPPGSRCHGGAAFIISNHSPYSSHLHANKSEAHMTGRSALTFACLAEFLCLGSVVSMLPRAHLQVQDARETELGCYILQQDVVESRRCTGDVQERISRCSPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNC3</accession>
    <name>A0ABY7FNC3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic peptide chain release factor subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_014685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR20711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="368" mass="40665" checksum="A5666AC29A56BD91" modified="2025-10-08" version="1">MATSGMHGTANGADQNVVRATRLLEEEVGTAACIKSQVNRLSVEAAIASVRQRLKLYSKVPANGLVIYCGSVLTDGRKSKKVTIDFEPCRPLNKFMYLCDSKFHTEPLKSLLEDDVTYGFIVVDGKETLYGTLSGSNKTVLHSFKENLPKKHGRGGQSAMRFARIRMEKRHHYLRKVAEGATAAFLADGQVNVHGLVLAGLAHFKTELSRSDMFDPRLQERVLKVVDVGYGGESGFNQAIELAAPVLSNISQDTGRFCFGVDDTLRALEMGAVSILIVWENLDITRYLLKNHQTDGTEILCLSDDQMKDRDLFQDQETGVELELQESMPLLEWFANNYKNFGSTLEIVTDKSQEGAQFVKGFGGIGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRU0</accession>
    <name>A0ABY7FRU0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VCX3B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_037971</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Interacts with hair keratins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PMG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007659">
        <property type="entry name" value="Keratin_matx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007951">
        <property type="entry name" value="KRTAP_PMG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23260">
        <property type="entry name" value="KERATIN ASSOCIATED PROTEIN 3-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23260:SF7">
        <property type="entry name" value="KERATIN-ASSOCIATED PROTEIN 26-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05287">
        <property type="entry name" value="PMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0416">Keratin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR24302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="500" mass="57905" checksum="9C1E8403F247179B" modified="2025-10-08" version="1">MSPTGEVNQKCVQWGKQHRNVSHWGSESKVCPMGYHRNVTRWGRYHRNFTRLDKYHRNVTRWGRCHRNVTHWDRYNRNISTWTDITEMSPAGADITEMSPAGTDITEMSPAGADITGLSTTGADITELSPAGADITEMSSAETDITKCHLLGQMSGNVTRWDICHRNFTRWGRCHRYVTRWGRYHRNVTRWGRYHKNVPCWDRYHRNVPRWEQISQKRYPLGEISQKYRPLGQISQKCHPLGQMSQKCHPLGQISQDCQPLGLISQNCHLLGQISQKCHPLRQISQKCHPLGQISHKCHPLGQISQKCHPLGQMSGNVTRWGRCHRHFTRWGRCHRNVNRWDRYHRNVTRWGRCPEMSPAWAYVTENSAAGADVTEMSPAGEDITEMSPTGEDITKMSPAGTYIAEMSPAGSRYHRNVSRLEQISQKYRPLGQISQKCQPLGQISQKCHPLGQISQKCHPLVQITQKCHPLGHITQKCYGWDRYHRNVTRWDRYHRNVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRU3</accession>
    <name>A0ABY7FRU3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="134" mass="15637" checksum="6E7C66F50C1E0155" modified="2025-10-08" version="1" fragment="single">MTESGWSNSLVCMEYSEQHFMKHVTTKEHPMMIMFDGQKSHINLNLSKWGETKKRLQQGSVCGKNPDECFPEDWYISTNEESDMCCQPPPPPRPFNAIDHSRDQEQSKQSSKDVQPESFLDSRKVVKTIKRREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSM8</accession>
    <name>A0ABY7FSM8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="351" mass="38895" checksum="74ABCCAE4CD4F2C4" modified="2025-10-08" version="1">MLADMFGLFVAMVALIAGTVFRPDNATVFDLFGVRSTLSKRRYLHGQCMIVTLVSCCVIKKSLIFKLEKMTALTSVCSCGAYALAATIFYKKNFKRSGLPIVFLCLVVGLLLDTALICAEVSAFGITVAAVILIQNDEWIGKAFKMDVFLAFLVAICDVRYGMFDWVTGLLFTNGMAVIVEKNSSRANPLEFNLDMRTGTFSQLDLLSAEESSSALTEAFLTIKSALSCSVPWEMARVILVAMPQFLRKPTWLKAKLQGLRSKLGPMYVLFVASYFFSRWGSYDNMLADMFGLFVAVLALIAGTVFRPDNATVFDLFGVRSTLSKRRFLHGQCMIVTLVSCCVMFVIELNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUQ8</accession>
    <name>A0ABY7FUQ8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">MAR_038247</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">MELC-2E11</strain>
            <tissue evidence="27">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00108">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018056">
        <property type="entry name" value="Kringle_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF317">
        <property type="entry name" value="MUSCLE, SKELETAL RECEPTOR TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00018">
        <property type="entry name" value="KRINGLE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00021">
        <property type="entry name" value="KRINGLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 20" id="KW-0420">Kringle</keyword>
    <keyword evidence="14 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 23" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045189975" description="receptor protein-tyrosine kinase" evidence="23">
        <location>
            <begin position="23"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="25">
        <location>
            <begin position="27"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="26">
        <location>
            <begin position="146"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="319"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="WAR24578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="613" mass="70017" checksum="3852A185608ABAAC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWH0</accession>
    <name>A0ABY7FWH0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="237" mass="27060" checksum="5C26CF49A219AF0F" modified="2025-10-08" version="1">MALLCVYNRDMTPMYPSCVYNRAMSPMAPPCVYNRAMSPIGPPCVYNRAMSPMASPCVYNRAMSPLASPCVYNRAMSPIASPCVHNRAMTPMDHMHVQPRYFSYGPLVRVQPRYAPYDPSLLRVQPRYVPFGPSVRVQPRYVPYGPSVRVQPRYVQNCPSVRVLSRYVPFGPYMRKLPCYVHYAPQCVYNRAMFPMAPPCMYNRAMFPMAPPCVYNRAMSPMNPPCVYNHAMSPMDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWK1</accession>
    <name>A0ABY7FWK1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35538:SF3">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35538">
        <property type="entry name" value="LIG_CHAN-GLU_BD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1195"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1684" mass="192045" checksum="34115ABE59E7CCAF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWW7</accession>
    <name>A0ABY7FWW7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045858563" evidence="2">
        <location>
            <begin position="20"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="867"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="912"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="928"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="977" mass="110444" checksum="D9D86179FB2181F7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FX07</accession>
    <name>A0ABY7FX07_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DCR1C-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="93" mass="10715" checksum="A9C0842101848634" modified="2025-10-08" version="1" fragment="single">MLVTGKSLLSETMSCFGGLMKEYDRVSLDRFDGRNLQSTVYFLSHLHEDHTKGLGGPILFKRLKSNKDIFLYCSEVTQVLLLASQKYRHLKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXZ8</accession>
    <name>A0ABY7FXZ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="328" mass="42822" checksum="0B12D4FC2932153D" modified="2025-10-08" version="1">MHYYTTITYLMYHYTTITYLMYYCTSITYLMYHYTTNTYLMYYYTTITYLMYYCTSITYLMYYYTTITYLMYYYTTITYLMYHYTTITYLMYYYTTITYLMYYYTINTYLMYYYTTITYLMYYYTINTYLMYYYTIITYLMYYYTTITYLMYYYTINTYLMYHYTTITYLMYHYTTITYLMYYYTINTYLMYYYTTITYLMYYYTTNTYLMYYYTINTYLMYYYTINTYLMYYYTTITYLMYYYTTITYLMYYYTTITYLMHYYTTITYLMYYYTTITYLMYYYTTNTYLMHYYTINTYLMHYYTINTYLMYYYTPITYLMYYYTTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZY3</accession>
    <name>A0ABY7FZY3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="141" mass="15689" checksum="92DA8BBA8355C629" modified="2025-10-08" version="1">MAFNELDLLESSLLSIRESNELIHIIISSVIVTKNNFINAKTELTNIKLQNVCKTHGWVYLNKGDIFLYDTVHLNENGENHSEARNLPISFTGCQSMNDGDSVNCKMCGVKLDSQTSASSSNIMDNDTLKAIKSRMAYLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0L1</accession>
    <name>A0ABY7G0L1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">E75-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_012315</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="98"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR26611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="177" mass="18915" checksum="7783BDF12D2AD3F4" modified="2025-10-08" version="1">MSDNQYLPRDVPSATKSRRRRERNVDPGAPSTPLPACRVCGDRSSGLHYGVNTCEACKGFFKRTLRKTTMDLPCGCKAVVKAIKIGRYSLERKTNNILESKREKQGLDQGILSDLHPPNGAVGNPPNGAAGKECNSKSCAQEMDNALATDGVDDIDAFIESLLGTDGQTGENSSTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1K9</accession>
    <name>A0ABY7G1K9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MCM7</name>
        <name evidence="10" type="ORF">MAR_012983</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="9">
        <location>
            <begin position="261"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR27279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="650" mass="73421" checksum="6EEE139AA6F964D5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1T0</accession>
    <name>A0ABY7G1T0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NLRC3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_012665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR26961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="750" mass="82901" checksum="6E8463FF6E004F27" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3M6</accession>
    <name>A0ABY7G3M6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="245" mass="28687" checksum="5C67606E269140CB" modified="2025-10-08" version="1">MYPNRPGDVDLKRKPAETAFKMVVDNPEQLMDKLGLCDAKAAHYFGLLANGDCVSNEIAGKVSFSSRNLVLLNMDHYRPRVKTLHPSAGLGIPDEYTHYFINSYYTRAIDQKRARSGVALTSVTDEQKSGAWKQIALVQVRAKRMYNSNKRYRKFCRSTNDYRKYCLLENQTLKELKKTITRVHTMRRDWLDKPYEYQIEYINNTKKNLKLWNDRLRLVSKQLRKIIKKTKTKTLQSNTRLVLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3R0</accession>
    <name>A0ABY7G3R0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUSTY-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_014504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26392">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26392:SF92">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="449"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="826" mass="95150" checksum="C3BD113F43307CFB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4H3</accession>
    <name>A0ABY7G4H3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MIEN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="233" mass="26356" checksum="98780A524C1FA31D" modified="2025-10-08" version="1">MEDILSELPETEVVGDVGRNQSFEVSINGQLVFSKLKTYGFPKAQDIIRGIQSAAQWEKCQEIVDSKSGKFRRAAQGEKCQEIVDAKSEIIKEIQRASQGEKCQEITDSESPWCINIHQHGDLCFPHHLCVTVARIIQALTLKVKITIISHLLLIRQDKIGVICQYPVTAINFGINVFGTWVRKIYLEPRHKAIALSVCPEFRHSQNLLRCRTAFNLQHKSSDLNESLTIQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7X0</accession>
    <name>A0ABY7G7X0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="123" mass="14255" checksum="112A92ED45D86029" modified="2025-10-08" version="1">MDMTSQIAFIRNGTPTPMTLCKNKVELRLGHLEFQNVRFILDTTVKVIRLYTVKPNDVGDHNSAKAKTMNGYDLTLQSVFQQDKRIVDQRIVDQRIVDQRFVDQHRDIEGKPANEYVAYGEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8W7</accession>
    <name>A0ABY7G8W7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="225" mass="26082" checksum="38E193F61376FE59" modified="2025-10-08" version="1">MGEECIFVAVGAVLGVLTLIIVYVIYYWCKNKKRRALVQFFDTTSFKHISKTFRSRYQNATFEIKYSKEEIVSDIPLVVFCLSTSRVEDECRSALEGILYTPSTTLLVVLHRLKDSDTSAVISFFKFDGHRNWIGFVNELLEQQHDNHGNQKNGLRLWEDGRGRRSWEVQKRHSIDQEKIRHEVLRKLNRECTICQTQMTSLGNQKAMLSRNLVIERCCLAGASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9U6</accession>
    <name>A0ABY7G9U6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ShKT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="1">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="1">
        <location>
            <begin position="162"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="317" mass="32968" checksum="7152D0953D02C7F6" modified="2025-10-08" version="1">MEHRNGFAELQTIATNSQHVFNVSSFDALNTLQAELKKTACRSAPSTPTCLPRAHSSPTPRTHSVAGYHSVRTPAEICARIASVPTGCSFGQDPRDACCQVLKCDAAQTFGTCQDKVNCQSYGNYVCGQQYEGWARENCGKFCGYCGGGTNPYLATAPPSGACVDAIPNCAQYDVSVCTDAQYRPWAVANCPKHCNMCGATGSGGVITGSGTAAPGTGTGTGTGTGTGSGYVGYSGGCVYKGRYYGAGDHWYDGCTCENGQTGFYRCGDRCPTYNLAAGCVLRTVAEQCCGVPDCTGATGTGTGTMTEPDVEGRVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAJ1</accession>
    <name>A0ABY7GAJ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PIF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="564" mass="64225" checksum="98488E4E88909867" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAZ1</accession>
    <name>A0ABY7GAZ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FABP5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="139" mass="15991" checksum="452B8CFE81D319A8" modified="2025-10-08" version="1">MSGAEAFMGSWREEEKEGYEEMVTALGLPEENKEFFKNARTKITCRRDGDVWEIDVGMHGVPHTRTFRFKPGEQYELASLDGSPMKSVVTVDGDKLQEKHIDDNLHGMDMNITRYIDGEKMIVETQVGELRMRSIYARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GHJ8</accession>
    <name>A0ABY7GHJ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FOLC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_033168</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR30626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="389" mass="44154" checksum="58F245071AC6C90E" modified="2025-10-08" version="1">MALLYQEAVKTLNTLQSNAQTIQKMRLERDKNAPLNIPKMLNFASRVGIQEADIDRLNVIHVSGTKGKGSTCAYCESILRHHGYKTGFFSSPHLIEVRERLEVGGMPIEQEKFATYFWDVYNKLDTSKEANDGIMPNYFGFLTLMSLYVFLKESVDVAIMEVGIGGEYDCTNLVRDDVYRVLIYNCTGDRETSTLMRPLVSCGFDAALFCPNIAYETAMSADQTNNTVTKESQMRRCSENKDSFNQMWQQRYLTLQNNQTSNVRSVQDLSSHTLPSISECINWVCKRKWQQKSSRGNPYVSSLYANEDYQNDVDIENSFNWVAVQHGTHFDMNTTNGHQPLSTSNRVNQSNVVDGQESKRSEKKHVQVLITGSLHLVGGALRVLNDRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D8A4</accession>
    <name>A0ABY7D8A4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EGFL8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_005984</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF56">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ93513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="170" mass="18668" checksum="184008F73AE1340B" modified="2025-10-08" version="1">MSERHSDIMEIPTVLFIETKNEKMLNKSIGYISQCAIALLMLRSVWDTCYQLIKQCCPNYEGSSCDTPLCSGENSCQNGGTCISANNCTCLEGFEPPICEDKNECNTENGGCSHNCTNRHGAFECSCNDGYVINNDNKTCSSPKDNSKKYSMATNVGGLPQLDTKKSEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBS5</accession>
    <name>A0ABY7DBS5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="152" mass="16906" checksum="830F5688C88369E4" modified="2025-10-08" version="1">MYSGQVKSQGVCTGMTPCFCQYENGQFLDISSLGRTDGEPRFVNPSIPHNIYNTLGLQNGYTFLKNISDNSITLQYTANKRKSHIKLVCTTGDLNSTYFNAIGPAYQDSPDYFFELRSPLCCPQGTPKVTTRRPTTSKPGSTNPNKESWQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DD81</accession>
    <name>A0ABY7DD81_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_007354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="22"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ94883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="366" mass="41798" checksum="8A05F22967B699D2" modified="2025-10-08" version="1">MFSDNIIQIEFRRISDSRPDKPQIVTELLVDYFSHETFEIMCTLNDVTHLNTLIWLILWQSDGTLQINLQNEDPSKTESYRKPTFYSNVNRWAAAGCFDNLTRNSRNSTLGVSRPVSSFTCTDARMYKCTVYYITSGMVDKLRYTQKRLKVRVTPSIITKQIFDASGDVETIISELTNTTTIIHVGQKLRLQCTANIGSFNSSVKIVWMKSSLDNSIQLVPFTSGNQIVGEPKAFGSCEFEKTDSLLYDVSVEDALRTSGNRFHFQCYVHIMSINWKTPEQHRPNFSFVVQLTGILVFIGDFCALVILGSVGIFLKRKFSNQRFSKADEKSEQTSPRPDETNTTFPLSRVIETSTEIDCPIYENYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DE62</accession>
    <name>A0ABY7DE62_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="107" mass="11228" checksum="F9F893E7933268C0" modified="2025-10-08" version="1">MEGNIAGTEEIHSAMASSQTLMLVVVLVSLTLTSAGRRACKMDGETKTCVEVVGRRGALKGVSLCQKKGGTCMALQKGGKSKRIKCQCMELKSGCGEVSQSGSVRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DH23</accession>
    <name>A0ABY7DH23_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MAP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="1">
        <location>
            <begin position="8"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="71" mass="8411" checksum="CCD8E855076EBFF4" modified="2025-10-08" version="1">MEFLIHGMDITVYYKGYHGDLNETFYVGKVDERYKKLVRVAWECLDLAIKEDCSIQHPMFLIMPKIKPSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DH92</accession>
    <name>A0ABY7DH92_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Diacylglycerol kinase</fullName>
            <shortName evidence="9">DAG kinase</shortName>
            <ecNumber evidence="9">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_028767</name>
        <name evidence="14" type="ORF">MAR_028874</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="9"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd20801">
        <property type="entry name" value="C1_DGKepsilon_typeIII_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF118">
        <property type="entry name" value="DIACYLGLYCEROL KINASE EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="11">
        <location>
            <begin position="99"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="12">
        <location>
            <begin position="188"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAQ96077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAQ96184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="522" mass="59522" checksum="58974F066D9750BF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHS2</accession>
    <name>A0ABY7DHS2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HS3S2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_028945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF72">
        <property type="entry name" value="HEPARAN SULFATE 3-O SULFOTRANSFERASE-B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ96255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="253" mass="29584" checksum="F3CE9A18E7C945F4" modified="2025-10-08" version="1">MRRIPKVIIIGVKKCGTRALLEYLKLHPLIKAPGPEPHFFDRNYHPTNDHEITIEKTPRYFVSQDVPEKIYNLSPNVKLVVVIRDPVVRAISDFTQAVSKNEVKSNQTFRRRVLRRDGDINTHSSIVKTGIYVRYLTTWFQYFGRSNIHIVSGEDLIANPLGVLETVQDFIGVQREIDGNLIYFNKTRGFPCIRMLKRNNTAKCFGATKGRNHVQTDSATLKRLYDFYRPYNQYLFKFMNKTFEWNVLQKIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIM0</accession>
    <name>A0ABY7DIM0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_029758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046683290" evidence="2">
        <location>
            <begin position="22"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="236" mass="25778" checksum="8D7632BD3E7FC93D" modified="2025-10-08" version="1">MSRLPMILVALCLLSTWPCGGQISRRRLRNRGNTPRRNDPSSGLPTHLQQAYYSAVNEDDGSNQPPASTTVRSTTTTSPTTTTTITVAPTRADRPGNFPDDDDAASTNRQNNLRWGTLAPTPPSPENVDCIVEVQETRWEGGKCTLLSGRSQRYVCQSGPYIAFSPVCNQRVYALRRLREEEARLSQETAQDVADGQEIGGQELPASITGSDFQGQITELAPDITPASSDSLSQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIW9</accession>
    <name>A0ABY7DIW9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_029959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026:SF10">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13383">
        <property type="entry name" value="Methyltransf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="129"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="281" mass="32857" checksum="4CA35C9B7B480C57" modified="2025-10-08" version="1">MASARRSSVLKWCTVGIFAPILFVTYKVTMIPMVVTEAEPEIQCLPTDFRDTQFIVGVHRNASVLIPEDLLLKNLSREDLSALYHRYLENVQYMCRRKVRLGNYEDGGWDICDDEHFRPPKPCIIYSFGMHMDDHQRSDKNYFHSLGISDKDEAIKANTDEWQLFTYNTIRQKLQHANKTISILKIDVELYEWRVLADIVKTANMTGTNNLAVEFHLALDGTEVEWEQYYRALTVLRNLYHLGYRIFWTHQNPNCAFVSACKMEQRSNCHEISFVKVTDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJ92</accession>
    <name>A0ABY7DJ92_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DOK7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_029673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037746">
        <property type="entry name" value="Dok-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21636">
        <property type="entry name" value="PROTEIN DOK-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21636:SF2">
        <property type="entry name" value="PROTEIN DOK-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="2">
        <location>
            <begin position="57"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="975"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1314"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1519"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="914"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="975"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1118"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1318"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1346"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1361"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1527"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1542"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1580"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ96983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1596" mass="177298" checksum="D2445DA13768F57C" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLK8</accession>
    <name>A0ABY7DLK8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CHSP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_030089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052069">
        <property type="entry name" value="Ca-reg_mRNA-binding_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12962">
        <property type="entry name" value="CALCIUM-REGULATED HEAT STABLE PROTEIN CRHSP-24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12962:SF1">
        <property type="entry name" value="COLD SHOCK DOMAIN-CONTAINING PROTEIN CG9705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="57"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ97399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="152" mass="16923" checksum="4D975F77887C19F7" modified="2025-10-08" version="1" fragment="single">MSTDIPDMQAANNQKIASHGRESPQSPAHNKFLLPSPIPTRRNRTYSQSERALKSMSYKGKVKSFCREKGHGFIVREDNKEIMFVHISDIEGEYVPKENDDVSFKLVPMPLNPAKQQAVHVKITHLAPGVSHETWSSCASHPVSGSPRFAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DN09</accession>
    <name>A0ABY7DN09_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondria-eating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_022297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031981">
        <property type="entry name" value="MIEAP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16026">
        <property type="entry name" value="MIEAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondria-eating protein C-terminal" evidence="2">
        <location>
            <begin position="305"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="387" mass="43595" checksum="E64F8D268166403D" modified="2025-10-08" version="1">MRVEKPPNDPNDWLSESGRKTERPSPLYGANDWMSTGSNRDSGPLLQDETDHAINRDVLRLETAGSRRTEVAQANRVALPLRPSPTPADTPDLPVSTRILESVLDRMGRLDHPSVLEVSAAARELQALKAKVAQLEGKLQNKADWRPGQQGKRGETEAEEASLREQVKRKDRLITDYQIRRDCGQLYRPVRAGMAIRARGSQVNVDRGAPHCDAYIFCTEQVKHQRTTFTDLSALMKEAMIRPTYIHRETNSKYKYNLAGEGTPELARTASQAAQLLDDYQTLMCSQTIPGIQELFLDIKLPEIVPSEGLSNSVRDFAKRVVQLTWLMVVHVPPILFAWLEPNAAVRKEQYEFYQKRIGKRVQTTVWPAVFKSEGGELLKKGVVMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSD1</accession>
    <name>A0ABY7DSD1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SON-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024363</name>
        <name evidence="2" type="ORF">MAR_024381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF8">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="374" mass="41412" checksum="0E581DAF263DE859" modified="2025-10-08" version="1" fragment="single">AHSNTDIQLDAHSNTDIKLDANSNTDIELDTHSNTDNQQDTYSNTDIQLDAHSNTDIQLDAHSNTDIHLVAHINTYNQLDAHCNTDIQLDTHTNTDIQLDTHSNKDNQLDAHNIQLDAHSNTGNQLDAHSNTDIQLDAHSNTDILLDAHSNTDIQLDTHSNTDNQLDAHSNTDILLDAHSNTDIQLDTHSNTDNQLDTHSNTDNQLDAQCNTDIQLDTHINTDNQLDTYSNTDIQLDAHSNTDTQLDAHSNTDTQLDVHSNTDTQLDAHSNTDTQVDAHSNTNTQLDAHSNTDIQLDTHSNADTQLDAHSNTDIQLDAHSNTDIQLDAHSNTDTQLDAHSNTDTQLDAHSNTDTQLDAYKQNKINNMHTSNTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTM9</accession>
    <name>A0ABY7DTM9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EB" evidence="1">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="94" mass="9180" checksum="1369B203609761BB" modified="2025-10-08" version="1" fragment="single">MSPKSRGSNDGWPGGICDGAGGGACSGDKNAVCMNGMCMCPGGYLMANGMCLKVGSLGGTCMSNACPGDKMATCQSGMCMCNSDSTGIAGMCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DU28</accession>
    <name>A0ABY7DU28_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GRHPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_024545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF277">
        <property type="entry name" value="GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="3">
        <location>
            <begin position="59"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="155"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR00173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="368" mass="39755" checksum="5C28F3DC93FAC83A" modified="2025-10-08" version="1">MVTAVSDFDRDVTEFRFVEKLGYVENKVPLVASSKRTMSERPKAYLTQKIPVDGTGLTQLQAVCDVNMYDEVEGGQISVSRERLLKDVVGANALILPYPVKVDAELLDAAGSQLKVIATVSVGLDHIDLKECARRRIPVGYTPDVLTDAVAEGTIGLTLATARRHKEGVQAVSGGSWGSTWDSCLYLCGQELRGATVGIVGLGRIGLGVARRLRAFSIGRLMYCGRSPKDYAGEVEAEYVSFDQLLENSDFVIACCSVNPSNHNLFDAAAFKKMKKSAILINTSRGILVDQDALYDALSSGEILRAGLDVTSPEPFPPDHRLLTLPNCLVLPHLGSASMRARHAMVDLAVRNTLAGLRGEPLETPVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVV9</accession>
    <name>A0ABY7DVV9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="87" mass="8512" checksum="8359F8DE4DECA9FD" modified="2025-10-08" version="1">MVQCVNVTASGKVQCVNVPAGGKVQCVNVPVGGKVQCVNVPAGGKVQCVNVPAGGKVQCVNVPAGGKVQYVNVPAGGKVQCVNVPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZ79</accession>
    <name>A0ABY7DZ79_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DPOL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_008134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd09275">
        <property type="entry name" value="RNase_HI_RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF8">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1048"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="555"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR01576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1204" mass="134148" checksum="C8DD344A7C0D2910" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZC7</accession>
    <name>A0ABY7DZC7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SIAE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_008589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039329">
        <property type="entry name" value="SIAE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22901">
        <property type="entry name" value="SIALATE O-ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22901:SF0">
        <property type="entry name" value="SIALATE O-ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR02031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="168" mass="18130" checksum="471BE8168C4F7A7A" modified="2025-10-08" version="1">MEILVLAPFRNGSSSLGFSEIRWAQTANYGYVPNPSLSAVFMAVAMDLPDFESPHGAIHPRFKEDVAARLALAARAVAYGDSSLDYQVCCGSTEAHKCTAAEWKAVSITAHDQTTVTMDTHVCSGQTHVVAGVRYAWHESPCAFMQCAVYGKDNGLPAPTFVKQAPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0I8</accession>
    <name>A0ABY7E0I8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="433" mass="49375" checksum="052955FE19B8C016" modified="2025-10-08" version="1">MTVDNATLHTKMDNNMKSESDTMYEKFLRSTSNRLQDDLRTEMSSYSRDKDRLVRNLAHLHPPPPTPSTASIASTQLPISPEHSSRKSKFYRAPNMVRSLYTESESSDFSGSSRSFDISPEHRRKDRKDHAEKVKKEREMLKLPIIHSASMKRSEWESGNTRDSHINVFPYNDPLPGISAAKAFLADSMKIPSIHDPQRTDTVYNRLSKKDQKKVTFADENHGSLISINHIEPSETEKTIRNSKNSERKVPVPKLNLAKKQYSHTARPVRPQKTSLLPPLHISANDVRSNPQMVTEGVNEWKSLYSSIMNPEEKTKALNDIMNAVRLKKYENEQAMKYGNGPRPLEAEELVKDYLDLNASGKITYRDEAGNAYSGCMPTPRSSPRLQNGFPNTFQLQNYLRQMSRTKRVLEKIDGQEYNNPRSAQPTPVSVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E253</accession>
    <name>A0ABY7E253_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NF2IP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_009594</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd01763">
        <property type="entry name" value="Ubl_SUMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052324">
        <property type="entry name" value="NFATC2-Int_DNA_Repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47187">
        <property type="entry name" value="NFATC2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47187:SF1">
        <property type="entry name" value="NFATC2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad60/SUMO-like" evidence="4">
        <location>
            <begin position="245"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR03036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="301" mass="34151" checksum="D29C5FC6C7492DD8" modified="2025-10-08" version="1">MSEKHQLDSEDDDDEYVYSNCVTNFYKRMRETSLKEQMRLADDDDDEDVEEDLFNMSSSPERNTNSSLLVKSPTPPPSPPKQLPKKARNTKKRKQLQRAMECLSSDIRTAQSELVAANTSADYDVLVLEDEDSEQVTMRVAIQGDIERFTYKMDDPFENMMNMIKGTKACDRVMLVFNDCTISRHDTPRVVGYSVGDIITCHLLNGEESFMEDSHTDTSSDCVEIVVQSNFSRQKEVILAKIKCPMSAVLSEYASRIKTPAEDLVLNFDGDVVDVTLTPEDLEVEAGDIFDVKRNNVVIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2G4</accession>
    <name>A0ABY7E2G4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="350" mass="40195" checksum="4EAFE7EDAAF961FB" modified="2025-10-08" version="1">MLSIYTVHVLVSVYNVQGLVSIYDVHSLFLPYKSFMKHHSSRPYKEALLHIYGPLVEDLFSLNLYLGKETKYEPKTIDGNKYIITPNRTTFLNRFVADVNQWSKQSETLRDKNTPFVQSYFVYADVAEVGSQRAPVVLRCGQITRDYTDCCSLTNALRVAYLEEDGWQIVFRATAGNGQSVYDAWTNGTSTISVKPVDITRANSSHYMRKNLRSNWERYNIKYVKMAVYKDNREAAYVIFNGEGSTADDWFSPNNVVDSSWVDLMSSETHNFFSILGADDGRVLRRFFINTLYRGCPGDIGHFAVIEEGVCSFDKHARFPQFIYSNQNGADFWQNRFAVVDYFCIFISTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2Q6</accession>
    <name>A0ABY7E2Q6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_009349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR02791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="270" mass="31277" checksum="8D07155C8107E73E" modified="2025-10-08" version="1">MYLNMKIQMNLDINRATLEFFRNVQNSIQSLQAMMESYRNVQNLQKCSEFHPKGLQATMESYRNIQNSIQRACRQQWNLTEMFRIPSKGLAGINGIFQKCSEFHPEDLQATMESYRNIQNSIQRTCRQQWDLTEIFRIPSRGLAGNNGILKKYLEFHPKDLQATMGSYRNVQNSIQNSFRTKLPGVYVKISTNIISSEMLAFYNLIWGEDEGLNRTDSMKTNMREQRTLTGGTTSVVCRCGKVCKNHRGLKIHQTKSGCKAREIHQQRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2R5</accession>
    <name>A0ABY7E2R5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="449"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="548" mass="64073" checksum="75609FC920E56E0F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3E8</accession>
    <name>A0ABY7E3E8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="87" mass="9350" checksum="274C233CD0213F56" modified="2025-10-08" version="1" fragment="single">MPSGRGRRTTRDSKVVALHVNNWICNITTTPLSSTVSSSTIACPSGIPGLIVATVTGWLLAATLFVISLYFFKCLRQSSTIAKPTEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5F2</accession>
    <name>A0ABY7E5F2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CSAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_020611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF8">
        <property type="entry name" value="CYSTEINE SULFINIC ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR05242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="292" mass="32877" checksum="624C9F347EC6EB7B" modified="2025-10-08" version="1">MLYIKPCLRGVAGVHLPFPICSIASHTHTYEVSLAFTSQYLYILVLPVTRTSHTYEVSLAFISQYLYILVLPVTRTSHTYEVSPAFTSQYLYILVLPVTRTSHTYEVSPAFVLLEQYLMQKICGIVGYPDGDGIFCPGGSMVNIMAMNLARYRKCPEFKTHGMYAMKHLKYYTSEEGALPTFVMATSGTTVLGAYDNLADIADVCQELDVWLHCDACWGGGALLSPSLKYLMDGIHRTDSMAWNFHKMSAAPLQCSVLVLKQKGLLEDCNRFRAEYLFQPDKNYNTEYDIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6L9</accession>
    <name>A0ABY7E6L9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="97" mass="11060" checksum="EAB0F4A9D2A51CE6" modified="2025-10-08" version="1">MVREVMDIHQPHNMAAYNESMGGVDLHDQVPFRPGFQDGATANANSIILFKQASSRPRFTHLDFRQELINQLIAGFNRHKRSSFENRPRVGIALENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E702</accession>
    <name>A0ABY7E702_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Malate dehydrogenase, cytoplasmic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_019573</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="5">
        <location>
            <begin position="160"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="288"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="443"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="452"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="484"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR04204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="520" mass="57199" checksum="BB454164F0837175" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7R8</accession>
    <name>A0ABY7E7R8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_021279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR05910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="255" mass="28139" checksum="F862BBD664D3506F" modified="2025-10-08" version="1" fragment="single">VPQCPTGLTYSATTSSSANIEWISHFNGGRKQTFIVLYKMTERSEYLVLTADEIDQKIHYEIILTGLNDGSTYEVILFSRNEKGNCKQNTSLQFDTELLVEPPPGTTGSIVGGTTGGIVAAIILVIVVVFVLKRKYNFDCLCSFRLSRKGEISSSNFIVEINTDLHHDANTDNGIDTQGADTRGYNATQTYEDISMVTDKSPYDALDNGDNGLDNVHVYTPLDAPCLKTHVSYENVKDDPVYNNTVLKNPIQPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7W1</accession>
    <name>A0ABY7E7W1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CEAM6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_020663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="6"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="126"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR05294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="205" mass="22270" checksum="33ACBFF2576B689B" modified="2025-10-08" version="1" fragment="single">SAHTKPVITPSGVVPVVQGSNLTLTCFYESNVTTFNYQWCSKNRAPAYSCLRAIGQDECVNVYADGSLYGIQCLGNNVLNLTIYNVQNADDGVYWKCNHEVGKSSTISEPIQFDVQDGINNVILSPSTTLYRVIEGNQLEAIICSARCNPACSYTWSTSGKTVSATGTLDLGQAERREAGTYMCKVQNTISRFSKNGPVVSLDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8T5</accession>
    <name>A0ABY7E8T5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NPHN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_020764</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="188"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="285"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="373"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="562"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="767"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="767"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="884"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="904"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR05395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="923" mass="100346" checksum="D1B1F7A360139749" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAP0</accession>
    <name>A0ABY7EAP0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_021231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF158">
        <property type="entry name" value="V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 10-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="163"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR05862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="416" mass="45507" checksum="905CD2C34C5D3749" modified="2025-10-08" version="1">MIIDSAQTVTCHSFGKPNPSNNNFTWTKGSTIVSSNSVLSWTGGIRIQDGGSYKCIVSTTMTPSNTSKTPVTTEVSSYVTMNITVVINRQFELACTATAHPTANYSWTVDSRTYQTQILQDTINTKTNTSGTCTAHNVLKPSVGIAQTPSSSASIAVYINYPPESVTVRHTIENGDIFNIMERATLLLFCESQSNPSSAFSWTGSNISQTGSVLLRNNISRSEKGNLSCTARNTMTHMDQPLEGLSSANFTLNILCIKLRTLNAVEEDADDLPDEVENPMYESSQPAAMKQDSPDVLYALSKKKDGDIYAVVDKTNKRPTKSQGTKKQKNDAHDNAGFDIYENNQSPQHPAKKNVNHDGLVYADIVFANPPKGQKRLVIHGIDDMTVYADVDLTKKVDPFPDSDEEDGGKKEPNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EC51</accession>
    <name>A0ABY7EC51_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_020090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR04721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="305" mass="33958" checksum="42D6D0974C6E09BC" modified="2025-10-08" version="1">MDKSSQTTSTPIAPVGNKRDLSLTPSDEYLAAESKKARPDDPIELSSITERHPDTACVTNVQLSKDDVTAISLQLKSLFTVEIQSSINNAVDALIPKVIEGINLRLSDEIESLKTENAHLKARISVLEISEDRLEHLEQYSRRNSLRISGVHELEGESTDDIVTKLVSDLGSTESLDEIDRSHRAVHGAMTRPSLVISLQKLYSVRSQAKHCPNLKKVFVNGDLCKARSDVFYLARSLVRKGNINSAWTSDGVILIRDNDMHLHRVTKARELDNFQSVTVPRTSPTSQRLSRLAEIDSAKKLNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECC6</accession>
    <name>A0ABY7ECC6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_017630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2130">
        <property type="entry name" value="DEAH helicase family, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042035">
        <property type="entry name" value="DEAH_win-hel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="58"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="182"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR07672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="417" mass="47104" checksum="686D50AFDAD73626" modified="2025-10-08" version="1">MNENGHRDGPSHKKFKFSQNGDDHYQKIRDERRQLPIYPARGRLISEVQRHSSVIVGYCVRFDDTTSEQTKIKYMTDGMLLREAISDPLMKRYSVVILDEAHERTIHTDVLFGVVKQAQRKRAKLAMKPLKIIVMSATMDVDHFSKYFNNAPVLYLEGRQYPIKVLYCKQEQSDYLFGALVTLFQIHREAPAQEDVLLFLTGQEEIDSAVKSIRDVSRTLTGDVPSMIICPLYAALPAQQQLKVFQPTPKGCRKVVVATNIAETSITISGVRFVIDSGMVKAKIYNARGGLDLMKVVHVSQAQAQQRCGRAGRESPGTCYRLYTEQQCNLASVVLQLLAMGIHDILHFDFMDKPDTDLTVEGRQMSAFPLDPRLSKREQALLARQKFLSSEGDHISLLNVYRAYKGVNGNKGLNGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEK8</accession>
    <name>A0ABY7EEK8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TM39A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_017144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM39 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019397">
        <property type="entry name" value="Uncharacterised_TMEM39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12995">
        <property type="entry name" value="FI21814P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12995:SF4">
        <property type="entry name" value="FI21814P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10271">
        <property type="entry name" value="Tmp39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR07186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="436" mass="50904" checksum="3702859BD0E7CA28" modified="2025-10-08" version="1">MPAGRRILSRLQTGPTFQPGPHKSLCAGHSDDRDANLIPLATMAVLPKHAHIPEIQGDTNISFEAMLYVFGFIVMCLQYINLYKTVWWLPNSHANYALNFYLIDPYLVAFLCVLMSRRLLWCFVQEIYGPRSGRGLLYMLVQACKVTLVSLAVISLFFTVFHVLRNHSLLYCLFLCCPIVTYIFLFGPTVKPLYLKSLNWPSSVAEKYSPKHKPGVDREQVLYHNCVMSPEVIRDEVENLKVDFNNRVKQILFNSMLTSYYMTFVPLCFAQNWKENHSVYNQNTLYYDTWWVGQHVFLTWLSAFLMLCAHFLPPRYLDLMHRCSQHLGRWQKGALVKHVRGLFKAEGVNVTAEPGNSMHGRFYFLFHRPLRVLNWMLILTWLLVGYQFFVLLQCSEWNHIICIALVLFCNYYTLFKLLRDRIILSKTYKDDDSGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEL4</accession>
    <name>A0ABY7EEL4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TTN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_016817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00108">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018056">
        <property type="entry name" value="Kringle_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050759">
        <property type="entry name" value="Serine_protease_kringle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24261:SF7">
        <property type="entry name" value="KRINGLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24261">
        <property type="entry name" value="PLASMINOGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00021">
        <property type="entry name" value="KRINGLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 3" id="KW-0420">Kringle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kringle" evidence="5">
        <location>
            <begin position="840"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="5">
        <location>
            <begin position="938"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="324"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="857"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR06859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1132" mass="124076" checksum="AC30ECF7E3BD5509" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGP3</accession>
    <name>A0ABY7EGP3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018:SF3">
        <property type="entry name" value="MYCBP-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="637" mass="72363" checksum="26CDF1A0B59256D5" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIA7</accession>
    <name>A0ABY7EIA7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PARVA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_018818</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028433">
        <property type="entry name" value="Parvin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12114:SF4">
        <property type="entry name" value="GH23568P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12114">
        <property type="entry name" value="PARVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR08860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="224" mass="25337" checksum="697B06D06BE2C87C" modified="2025-10-08" version="1">MATSPNTSTLSKKKDESFLEKIGTLGRKKKTKEALELQEEGKNAIESPTKKLAKIKVEVPEVSQSEQGQKQKLRVILEVINNILNLPQLGTWNQQKWSVDSVHSKNLVAILHLLVALVRHFRAPIRLPENVQVFLVVVQKREGMLQPRKVAEDITGTNEDVGGKFERDAFDTLFDHAPDKLNLVKKTLVTFVNKQLMKVNLEVQDIHSQKKCSFNVVKLAEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIK5</accession>
    <name>A0ABY7EIK5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HMCT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="126" mass="14506" checksum="ED63C81BFE4FBDCC" modified="2025-10-08" version="1">MKTCDNRLVYDTLIQDCGQETCVEGCDIKPCQPGQVYESNKEPFKCIPEAFCNTTCLTLNGKEYKEGERILDSTICRMDCENPVIRYLRLKFVSRNTQTSLKFNRQNSFSLDFVTTTCISTIMSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJ77</accession>
    <name>A0ABY7EJ77_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="301" mass="32889" checksum="1898183A097AE97E" modified="2025-10-08" version="1" fragment="single">FFKKEVFYLRDKVDSPINSVLRKQPGSKSNTEKNREKLHLYEIRTMSTADVKVVVLRSPNKKKPGYFTLSIDIVPKKNADSVIKKRQKENYEVDECIVPPTSPDIELPLDKDKKCKVKLIIEGGLKPAAVMHDYSEKGARKVLLLVPNNVSDNASIVFKVGGRFKERINIVDVPCQTETVSPGLAALNISGGATSRDSTELKTSYRGGDTSYDAGNLAKPVLPNSGVTSVPDVSDDVVEGAMPVSSTTPTSGGPFPDGSQPLMAKPLLTKTGHSPSLLLLLVLASRKDLRMRQMNRPTKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJE9</accession>
    <name>A0ABY7EJE9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="524" mass="60882" checksum="665DEE8763E035BC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKE3</accession>
    <name>A0ABY7EKE3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="504" mass="57830" checksum="BD4B0DF02A9B1F26" modified="2025-10-08" version="1">MLENGIACRWNWKRYPSYHDIPGCCLFTSAFEQKVHRMASGRHKQPFAREHSLRKLDNAGQLNIKKLADAGFYFHFDSVTNAQYIKCYACNCVLKDIRPEEVENIWSIHAQSVHYPDCTHVLNRKGLDYMQENQDGQWGEMKGYNSETVRTRCWKEKPQPRVVSKIDEITYRTLQRHSMEKGSLPTGVNYAVERYPEMAYENKRLEMMNDSMYEQHAKAGFFRENIGDLGKDVVRFDCDVSAATLCGLLRTGKTLGKNTFFSNMPVHICCLEKGQTSFERRTDGIAGDSAFCPIQQHRYISMSENGDLCQLQMQQYCLEQRGHLAIGCGVCNFTCHGLSLQESIRRHIREVPTTKCLAAITSVGGLEVSRICAKDGLVYPAGKKDFVSSLLEVWPSDAKLFREIVLGSPATLNMSQGICRRMSFSHMDPRYLHRIDTDGLSEAGFYYSIERDSVRCYYCDISIGKWRDHVYNRDPFVEHCLTHPYCPHIILTKGLFYVDETTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKX6</accession>
    <name>A0ABY7EKX6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046487144" description="EF-hand domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15393" checksum="189113FF26B86DA9" modified="2025-10-08" version="1">MMVVYNMGFIPMLILTLLVVTVAGRALKSNVSGEEHMQNDGVIMRAEDGLRQYRGPAVHHFARHGLCNHSFGKVRFFRALEKHFHHISDDMKISFVLDICERRDEMLTKWVQEIFDKDGDGYISHFERDIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELE6</accession>
    <name>A0ABY7ELE6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LRAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LRAT" evidence="1">
        <location>
            <begin position="29"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="262" mass="30462" checksum="41954CF74DDCCE02" modified="2025-10-08" version="1">MLRCQQYSVGQIAEIPGCIVWSASDVSNHIVFYGYTYDHHGIVAEINRKPNSIKVIEATNTFLGSMFGIIRFQKARIIETVKRPNFKSSIIQLVVYKHRKYTNNEIVQRAREFAIDYKYNVFNNNCEHFATECVTGHAFSAQIGKYEIALKLFWQGGLSAIFDERKRNMSMNRIKHICDTCYKKNTLLLGVPPTPITNKNDVKKGDIIRYRYYFVNHEAVILEASYKEKRQIIKCHIAHYAFRLFSCNPMTIQEEVISIKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EM87</accession>
    <name>A0ABY7EM87_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_034922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF291">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="77"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR09846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="357" mass="40480" checksum="682FCF29CA382EB9" modified="2025-10-08" version="1" fragment="single">MASNLSSSVYQTSDLIHDFACSPCKDDGLNNEAQFCCGECRKHYCNICVAHHNKLFRKHSVLGKQDLSKWLGYAGHSPIEICDKHGDKKLDMLCEDHDELVCYVCVSLTHRMCQSIKHIPDIAGKVKSTTEFKQFPFNVRLTSSKLQSLSDKTLQNKQSLKDAGKKILAEIKSLRKKLNDTFDELETKTNTILQDQLHDVDEFLQEDIDKCTQLHDKLRTFLEAIQSQQDDTSYIAYRKCKDKMREAESLIQELSVKPDTILTFHSDPKIEQLLSGLNTLGETIAFPCKNTWKYFPLSHVFKVKNISKSIVKMQSDVEGCGLGGICELPGGEILITDFKNNKVKLLDSQYQVTATCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMJ3</accession>
    <name>A0ABY7EMJ3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LAR4B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_035273</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd12430">
        <property type="entry name" value="RRM_LARP4_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058699">
        <property type="entry name" value="RRM_LARP4/4B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF131">
        <property type="entry name" value="LA-RELATED PROTEIN LARP4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26088">
        <property type="entry name" value="RRM_LARP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="5">
        <location>
            <begin position="526"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="385"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="710"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="874"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="932"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="997"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="718"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="942"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="997"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1008"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR10197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1067" mass="116676" checksum="1D3977CE4C1095B7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMV7</accession>
    <name>A0ABY7EMV7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_035217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF126">
        <property type="entry name" value="PROTOCADHERIN FAT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR10141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="26177" checksum="05C0B6848BCBDADC" modified="2025-10-08" version="1">MTPLEVEGCLSILKRVATITQWQGIQADGSTAISNFPAGADSIAASAILLSESVTGTLFTLTATAGTGTVSYAFASDGNPSSIAATTITAAGVVSLATGSSFDFETTTSYVFKIVATSDSGATDTGTATLTLSITDATEWSQSEYDACLSATSLAAGASIGTYNSTDVKSGQTVAYTNTGGTDTAKFTIGAASGELTVASSQTLETSTKYIYTVQLTATVSGVTPGTTTVNVKLGCSSGTSQITVLLCVLLMSVLTSLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPB1</accession>
    <name>A0ABY7EPB1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="65" mass="7493" checksum="0A53D1406B9D7BF9" modified="2025-10-08" version="1">MFRLSDNVTERRFLSDLTNDLYICLGTYGVFLSALAVDCFANMVIEHDLNLLLRSKEIAYDSQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPU6</accession>
    <name>A0ABY7EPU6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HIP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_026183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF116">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046722618" evidence="4">
        <location>
            <begin position="21"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="53"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR12003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="188" mass="20977" checksum="AA1F99D1B90F61AE" modified="2025-10-08" version="1">MVSFKNIILFAGLFVYVVNAEIKKRFVNEIDIPTLVQRLDDLTERVAENERKLRYHPVAFKAHLSQKMVSPAPNQRIIFDDVQLNIGNAYHGNLGGFIAPVNGTYLFSVSICSDGNHFIVLDLMRNSNMIGRVLAGDTVYNDCSSETTIAELKSGDEIYVQHHLNVGDLLQVQQHTLDSFTGALLAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPW7</accession>
    <name>A0ABY7EPW7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">carbonic anhydrase</fullName>
            <ecNumber evidence="4">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_026217</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF141">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR12037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="188" mass="20907" checksum="798DB4F08DFE8F1B" modified="2025-10-08" version="1">MNCSPHTWATKFPDAAGHAQSPVNICCNDVIYDSALNMTSLKTTYDVEDSFEVVNTGESFKVNIKKNSELTGGPLKDTYRLEQFHLHWGSNDDHGSEHTIDGQTYAAESGAEHPGFKNLVDTMRNVKSRGQTCTVLKTFNPASLLPGNINSYWTYHGSLTTPPCYESVQWIVLRQPTQYSPKQLQSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQB5</accession>
    <name>A0ABY7EQB5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="174" mass="19223" checksum="C046995264E0FAA2" modified="2025-10-08" version="1" fragment="single">MKKSISDSSSAWINTLTLASGGDWSLHVTANLQPRRDTGNINYSPKADISPIVRLRRGCNHTITIPVSDVDGDIVKCRRASQWHNKLDECASICSAIHDSWLDNNNCVLTYMATTNGWYAVALQVEDYANATDAFPLSSIPVQFLINVYDSQNNSCLKPIHFVSPTFPDMSCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERF6</accession>
    <name>A0ABY7ERF6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6570 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_026757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF8">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="2">
        <location>
            <begin position="45"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR12577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="675" mass="77903" checksum="CE4DF7C2E3933154" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ES17</accession>
    <name>A0ABY7ES17_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ASTE1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_026104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039436">
        <property type="entry name" value="Asteroid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12813">
        <property type="entry name" value="XPG_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asteroid" evidence="3">
        <location>
            <begin position="108"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="705"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="714"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR11924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="770" mass="88212" checksum="E06C7DF88C2EA3B9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXY4</accession>
    <name>A0ABY7EXY4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_004915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR14810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="243" mass="28084" checksum="75C5E808C8EB4D3C" modified="2025-10-08" version="1">MAPSMAEPDNIIWCGLSYVLVKYIFRDDPSYQNALRAGFLGCAFSLGLIISFLMPTISHFGWYLTALSFFHWSEYYTTAVTNPKSLSLESYLLDHSKEYKLAAMASWLEFSLKHHNYISRVGLFLVIIGEVVRKLSMITASTNFNHYVQYQKQKDHQLVTSGIYSLCRHPSYVGWFTWSIGTQIILCNPLCLVGYTAVSWKFFKQRIYEEEIYLLNFFGEDYVEYKKKVGTGLPFIKGFDGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZ03</accession>
    <name>A0ABY7EZ03_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPSX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_003986</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd14969">
        <property type="entry name" value="7tmA_Opsins_type2_animals"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="49"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR13881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="352" mass="40134" checksum="5D046C0FB5B07166" modified="2025-10-08" version="1">MSYVNETVIPDNPYKGLTFLEVKRIQYPVWGHQIVGGFLLLVLIGGFMENLLIMFIFWKNKELLSPTNIFILAVAIGDFGMACLGVPLPIIGALNGKWFMGEFLCKWQAFVVYFVGLSQMYLLMAVSVDRYVVITKPHLALRITKKVAIACMASCFGLAFFLALMPLIGWSSYGLEASGVFCGLRWEDHSARNTSYIAMIFFFCYFGPIGVMIFSYYHLFMAVKMRNRNTVLDVNSRVARRNIKIEIRLLKSCVVMCLVYWAVWTPYAIVSLSQVCGYSDSIPLVLTEIPRATAKSQIVWNPIIYVATNKQFRDAFYATLPCKRLREKVQKPPEERGKTHDRPDEDHETTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZN9</accession>
    <name>A0ABY7EZN9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="45" mass="5327" checksum="A8B2D648D524D77C" modified="2025-10-08" version="1">MLLDTEGSGDFEQHCTGKTEDKKRKRIENFVRSINVNKIFRKEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0V2</accession>
    <name>A0ABY7F0V2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IHOG-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="81"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="302" mass="34220" checksum="0413611572FB0A28" modified="2025-10-08" version="1">MTVEDEGTYMCKANNGLNALQLDGLKVLMLKVSGNRLYIAHAEARHKGLYQCFAENRVGLTHAELLVNVDITIRDTVKLVPPSIPEVKQLSDQSVMLNWTVPENKGPEIAFFRVQYKWLLSMSKDSKLKDNDNRWKTPDVEINSHVRQFEVSGLKSRGTYKFCIAAVYSNNDNAYSDYHIPEDALASSPIEGFYIYYKPYHSSEPFQNVTLLEPSVRAHLLQDVMLGTEYLIKMQSFNAAGNRSFSNQAVMKTEGESSENPDIIILPPPMTKYPPTARTMMMENPTRMRAVRHVSQAARCCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F113</accession>
    <name>A0ABY7F113_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeo box C6a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="28" mass="3226" checksum="028566DC6ACCD62C" modified="2025-10-08" version="1">MRGQGYYGAAIMCGRFRGVQARIREQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F286</accession>
    <name>A0ABY7F286_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="608" mass="67323" checksum="530BD2802A59EB0F" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3K3</accession>
    <name>A0ABY7F3K3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PKHM3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_005398</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17679">
        <property type="entry name" value="RUN_PLEKHM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051366">
        <property type="entry name" value="DEF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047326">
        <property type="entry name" value="RUN_PLEKHM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326:SF12">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY AND RUN DOMAIN CONTAINING M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RUN" evidence="11">
        <location>
            <begin position="45"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="10">
        <location>
            <begin position="684"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="210"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="748"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR15293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="768" mass="86055" checksum="A1810EFC2B6137F4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F484</accession>
    <name>A0ABY7F484_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="236" mass="26890" checksum="57C99FBB52C2FB3E" modified="2025-10-08" version="1">MKQPHRDILQKKQSKRDKKYKTLNADAWGQSTQRAGKKEHITQGSLAPEHVCTDVKSISEVFEKSACEHIGYVRMLSWFVSITNGTCTLVDELLHCVAESIWREREQIESCVLHMRSALRYTHVSSMFPAYPFKWKFCEVVWCENFHKFTDAQVACFVRCLLGPAAICIGGVLAFLCLGTAVGRIFNNSFIAWCIEALLGMIVAVIWIGYKPKLFTLFSVVNILKFVIDCDCCEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F897</accession>
    <name>A0ABY7F897_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">IDHP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_031841</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="10">
        <location>
            <begin position="47"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR17247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="296" mass="33181" checksum="F911F21B5CE901CB" modified="2025-10-08" version="1">MASSVAKIVKAVSRKNCQLQNFVAPASLGVQQKRQYGDHKRIKVANPVVELDGDEMTRIIWEKIKEKLIFPYLDVDCKYYDLGLPYRDATDDQVTIDSAEAIKKYNVGIKCATITPDEARVEEFKLKKMWLSPNGTIRNILGGTVFREPIICEKIPKLVPGWTEAIYKATDMVFDGPGKFEVAWTPVGGSETKTQVFEFKNGGGCGMAMYNTDELPLSLPRAKYVKEFEKLGIWYEHRLIDDMVAQALKSSGGFVWACKNYDGDVQSDVVAQGKLADGNLVCVMKIHMIMTLGKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9M7</accession>
    <name>A0ABY7F9M7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_032453</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046565730" description="Ig-like domain-containing protein" evidence="8">
        <location>
            <begin position="28"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="28"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="185"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="450"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR17859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="565" mass="63529" checksum="9540C23A595E7CE3" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9Q7</accession>
    <name>A0ABY7F9Q7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CUBN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_032336</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0420">Kringle</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046251033" evidence="5">
        <location>
            <begin position="22"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="24"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="7">
        <location>
            <begin position="231"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="368"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR17742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="493" mass="55150" checksum="490224CBB2BED94C" modified="2025-10-08" version="1">MHRFFVFVTVWMQILTPEVETASCGAAIQSHYGEITSPNYPSNYPNNTNCVWNITGPPGSRLMLQFVDFQVLQSTNCVTDFVQMYFDGNSTIKLCGGFNRWKKWLTNENRFDIFFKSGFGNITEKRGFRLLWKGVGTTFLTSRTTSWSQAQGMCSKEGGTMLTDDTYIGLSKEDLASQMDLANVTKAWIGRYYTPPEGQFVSTADYCKNPCPGNEEERCGGNTAMTVYMNDLCFNNSSLWNGTISTSRSGETCRSCNSSSHRCANESVDNTDSFCRDPRNKGNTWCYTRNGPEDCDIPKCLAGLIATAPMTWTGGRDKCRDSTSSDGEITYSMADTRHVLLDSGQDFWVGYRRTVRTVSDLSGSFTDCFRVARIENGISLTVDNFPNTTRTYDPDHNCVWKIMATPPEKMEIYIEFDLEDSVGCISDKIKIYDNDSLKGQANKILCGHGNITFSSSGPSVVIQFISDESVNGTGFNVSWKVAEETQFVRYTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FA50</accession>
    <name>A0ABY7FA50_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_030790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000138">
        <property type="entry name" value="HMG_CoA_lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01062">
        <property type="entry name" value="HMG_COA_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="43"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR16196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="327" mass="35032" checksum="CE4AF8D33EB6B41A" modified="2025-10-08" version="1">MSRSWLFCCSMNSHFRKKKCINLIDTLSKSYSQVSIAGIPSFVKVVEVGPRDGLQNEKELVTTAAKIELVNKLSLAGIRNIEVTSFVSPKWVPQMADHTEVMKGITRYDNVVYSALTPNLKGFEAALEAGASEVAIFGAASESFSKKNINCTIAESIDRFGAVVTAASRARLPVRGYVSCVLGCPYEGDIAPQKVAQVAKLMYDLGCYEISLGAMKALLAEVSKVIPVEKLAVHCHDTYGQALANILAALQMGVSVVDSSVAGLGGCPYAKGASGNVSTEDVVYMLHGLNIKTGIHIERLIEAGQFISKVLKRPTHSKVAQATKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAT8</accession>
    <name>A0ABY7FAT8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="720" mass="82147" checksum="27DD90D3A3402BEC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBV7</accession>
    <name>A0ABY7FBV7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fucosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_001413</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">Golgi stack membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="107"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="174"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR19575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="485" mass="53755" checksum="661D836A10FCA306" modified="2025-10-08" version="1">MKNVTSIKVFGKCGVSRLNGNISFEQKYKFYLAFENCLCDDYITEKVYHWYSKDIILVVRGGANYSEHLPEGTYVNAADFRTPEDLADFLNKLGSDEARTQAVPTDSERCQGCTQKNAIGVMGFLDDCSKYVYCAIDTKGVVHGAVRPCAFGMNWNLDILSCVLPSNSTCVTTKDICNEKSDGIRRPGVGNCRGYLECKNGESVALCCPIDYYFNGMTDNCESNNGDHECNDKCFKEITKTVEDKTTAPSSCYNKRPMTGVLNVYEESVKGKGWIQRRCPNGLLYQQKDCDCTLRVVVQRKCEPDLFLSFENGVNGQSPVVNYIKSKNVKVIDGKAIFKAEKGSQLVIQRYKNFCMTSLTINLKYFSDHKRLPQSQAIISNSDCGIAPSIVLTEDSAYVYFTVATELGERTLAVHQPSHTNDKNLELTYHNGILSGTVNKLKKTLKINGSGINKIPCALHVGSAQGYSGLNFTGVIDELSLSLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCK2</accession>
    <name>A0ABY7FCK2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR17021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="57" mass="6524" checksum="A06D62933FE81234" modified="2025-10-08" version="1">MAVEHEVSVLNAVRKIKTMRRLAIPNEEQFVFCHGCVSEYLSSFDVYAKFSEKTGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCQ9</accession>
    <name>A0ABY7FCQ9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CALN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_001761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR19923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="92" mass="10437" checksum="5B651D39D96407EF" modified="2025-10-08" version="1" fragment="single">METQLTEEQISGSGTIEFPEFLTMMMRNTRQNDTQEDLRAAFTVFDKDASGKISGAELRHVMTNLGEKLTDEEVDEMIREADIDGDGEINYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FD73</accession>
    <name>A0ABY7FD73_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WxxW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_000564</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025155">
        <property type="entry name" value="WxxW_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13330">
        <property type="entry name" value="Mucin2_WxxW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="WxxW" evidence="5">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="WxxW" evidence="5">
        <location>
            <begin position="130"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR18726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="244" mass="28360" checksum="D7C4807E801E9AD3" modified="2025-10-08" version="1" fragment="single">SKNLYQPKSFNENLTSRNRRQISQCETWSSWVDNNHPVIKAESEEERFTEKDLEAFCPANLGTITGFQCKDDRGEPRSNILNETSKDGRYSFSCYDYTIGVKSHNLYQPKAFNENRSIRNRRQMSKCETWSDWVDINHPFNIGDSDEEHFTEYDLESFCPANLGSITGFQCKDDRGEPRSNILNETSKDGRYSFSCYDYTIGVNFGFNAIVSIPKLFKRLDIRDIRSTADNNDHGRGRLKVHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEX7</accession>
    <name>A0ABY7FEX7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="154" mass="17711" checksum="466F34B52E819A4F" modified="2025-10-08" version="1">MVKLEAVYDTLPEIHVQCWFMFCWHGLVEIDEEEHQMEAHLTQVFLHMRLQLLPVVDFCRVSLTECIIAEKDTKYTTRNSKYPSSTRANMNKGASTPISVFFTGNFPNTSGQPTGVFYFSGKVRNPPMFSGAISMKHILPVTFQYLMKTSYTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FK74</accession>
    <name>A0ABY7FK74_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="104" mass="11060" checksum="F705D7C5D31D84DD" modified="2025-10-08" version="1">MKSIKRANSDYDDGYKGDYDDGYGGGYKGDYVGGYKGDYDDGYGGGYPGGYGHKYEGGNDDYDDGNYNEYNRGYGGGYRCGNGGYGGGHGGIGGEYGGYHAKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FL30</accession>
    <name>A0ABY7FL30_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RHG29-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_036424</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054713">
        <property type="entry name" value="GMIP/FCHO2-like_FCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057028">
        <property type="entry name" value="RHG29_45_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22699">
        <property type="entry name" value="GMIP-like_FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24235">
        <property type="entry name" value="RHG29_45_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="F-BAR" evidence="7">
        <location>
            <begin position="188"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="596"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="489"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR22755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="732" mass="82346" checksum="FAEBCD00216EDA59" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMA1</accession>
    <name>A0ABY7FMA1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NOTC3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_016443</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052108">
        <property type="entry name" value="MEGF/SIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035">
        <property type="entry name" value="MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035:SF109">
        <property type="entry name" value="PROTEIN DRAPER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="56"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR22469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="564" mass="61625" checksum="CE310D04F6671CC0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNY1</accession>
    <name>A0ABY7FNY1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ASI1B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_036693</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="102"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR23024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="195" mass="22558" checksum="727FBBACC0B4FF1C" modified="2025-10-08" version="1" fragment="single">RVLLQGVCNRDKAVCAKLREHVNDLWIINNNFLKVNIYYEDLNFNNVTEEPQIEIQQFLSDVGGAFGLWIGLSILSFLEVVQLLVELCNYFVAKTCKERRGRRENDRRGNLSNNIGFHSDDKGHGDKPVGYEHDDHRRNDNGRFRPTFDDDRGHHAHLSAYDARFLNQGRNGPFNNEYDRYSGRNHSDPESGHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPW7</accession>
    <name>A0ABY7FPW7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ornithine decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_036417</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="7"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="10">
        <location>
            <begin position="45"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR22748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="213" mass="23747" checksum="47902941FDB73874" modified="2025-10-08" version="1">MKTYMETTPIELHPFSQSIHSIVEQHVQAANKTGGDDPFIVGDLGDVIYKYRNWLRNLPRVKPFYAVKCNDDSTVLKLLADLGANFDCASKAEIQKVLSLGVPAGRIIYANPCKQASMLRYAAKHGVSMMTFDNEAELHKVKSIYPDAKLVLRILPPSNFKVQCELGIKFGCHPSKALNLLQLARDLDLNVMGIRYMFGKTLVAGLIGRTESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FR05</accession>
    <name>A0ABY7FR05_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ethanolamine kinase</fullName>
            <ecNumber evidence="5">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_036852</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="5"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR23183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="111" mass="12583" checksum="5B0416CB66B393E0" modified="2025-10-08" version="1">MAKVKHFNLRRIHCHLLRVHTFAKVFSNGISNQLYGYYLYDQLGETVLIRINGVGTELFTDRVLEKEIIKTLHARGLCAPLYATFNNGIAYGYVSGETLDADSVRQAHIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRJ2</accession>
    <name>A0ABY7FRJ2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NPAL2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_037593</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIPA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR23924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="272" mass="29941" checksum="F99AA36B606889ED" modified="2025-10-08" version="1">MANESTTAAITAQTESTADELHYQKYTHMKNEELEVKIHYTRNPLWWAGVSMMIIGEVGNFSAYANMFLAAIFLKEKIGPENLFASFSVISAKAVSSMIQLTFAGDSQLKYLNAAMKKFESTIVVPTNFVFFTISAIIAGIVFYREFWGMTALEIFMFLFGCCLSFVGVYFIVAGRKIPAAIVEATHATPGEPPVSIASKIFPAWLLATMNVGKVQPSGYVSHISDEQDESRRPFVAADGADSDSSQDTLYTTYKPEANGINGNMNYGTDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTR0</accession>
    <name>A0ABY7FTR0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FCHO2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_037765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046015542" evidence="2">
        <location>
            <begin position="24"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Muniscin C-terminal" evidence="3">
        <location>
            <begin position="273"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR24096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="362" mass="39158" checksum="5F75F2FD5D9B24D3" modified="2025-10-08" version="1">MLGKGCRLPCFGLFSLTLNLVNPENGDSKSWYDSSDSDSDQDSDMKIKVNIKPLSPSGVQATAANVDDIRTSKKGRNTPVDKKMMKRSQSESDTLDDLLNQSSSSEMGINSASQPVQNGVVPPVPQRPPSRGAPLVPARPSGRNSPFSLNRVDSGSTVQWNTTSMPVGSSRGPSPLTIGMADTVPLAVAFTETVNAYFKGTDATKNSSQAIDENPVYTFDMAALSDHLRHQGEVNKTASYFNIDILKYQIKVQPGVESTPYQCACTGNVMRKNNETKRATWRLNDISEVSENCSQGSIRAKFNLEDGKSTPSTTALQFIAESATMSGVEFELVGTGYRISLSKKRCGAGKYLADPDQVVKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FV97</accession>
    <name>A0ABY7FV97_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">KAT2A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_011781</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009464">
        <property type="entry name" value="PCAF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06466">
        <property type="entry name" value="PCAF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="10">
        <location>
            <begin position="434"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR26077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="725" mass="83194" checksum="EDB013EEA299EBAC" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVB1</accession>
    <name>A0ABY7FVB1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR25002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="220" mass="24214" checksum="2AB48A86AE4BDA21" modified="2025-10-08" version="1">MVEVNVISYHLIYSRCTQLRDDGSRGELTDRIIIYSVLYKTCSEFHGIVSKEGIVSSEGNSLDVVSRCKWRELGWELKVQGAGAGVEAVVQGAGAGVGAEGARGGSWGWSCRFKGRELGVQGVVAVGPSTGNWGWELWMQRVNWSCRCKRLELRYGAMDARDGSYRCKGWELGVGAVCARGGSCSRCKHWELGLEAVGSEGNFDEQKRRTCILEPRKLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FW64</accession>
    <name>A0ABY7FW64_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BICD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_011566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BicD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018477">
        <property type="entry name" value="BICD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31233">
        <property type="entry name" value="BICAUDAL D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31233:SF6">
        <property type="entry name" value="PROTEIN BICAUDAL D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09730">
        <property type="entry name" value="BicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="279"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="546"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="768"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="11"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="326"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="408"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="636"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="281"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="812"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR25862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="827" mass="94540" checksum="4D7BF5EE077BB545" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXN6</accession>
    <name>A0ABY7FXN6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NICN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_011343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040235">
        <property type="entry name" value="Nicolin-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31239">
        <property type="entry name" value="NICOLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31239:SF2">
        <property type="entry name" value="NICOLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR25639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="233" mass="26517" checksum="8B00E963BE4BE69E" modified="2025-10-08" version="1">MAERPLHCTIKNPVLITLTDLKSEFHSGCRIIDVSLSNIINPEVGEIHFKNSYTAYLTVKAKSKIQDSKDGGEVKWRTCVRKMRLMPSPHVEAGSQDFFVITRKQMSFDLVNVSALRLILQQPSPVWKEFKIEDLKIFRSSESSRPNPLPAWLTDTPDKTTRKKVEQSEEDWYPPPVVKKDADIMGVANLESLSSSLQQLWALSEEVSAQQTNRALGRYEVDGCYEINLLSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXR3</accession>
    <name>A0ABY7FXR3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16155">
        <property type="entry name" value="DED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16155:SF19">
        <property type="entry name" value="DED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="658" mass="75704" checksum="E8293510039DEA4B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYK2</accession>
    <name>A0ABY7FYK2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TLR1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042342">
        <property type="entry name" value="TTC22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16253">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16253:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="21"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="369" mass="44507" checksum="C255E0FC3144B2E9" modified="2025-10-08" version="1">MAEVENTRRKHSVIPQLPLDKRYHVFVCYVKENVNDVRTIVGNLEKAGLKCCYHERDFIPGQRTWDNMHAKIKESMHMLVVLSEDFSRSHFAKQELYEADVAESTEDLNIIPLKIESCDVPAILKNKTYIDCENNDITEIHYKIIEAVIDNGQKTRLKEEDSGEAFSISTYQKPGFRLLPRYKLEFVAEMRDKILMKSKDLFIRKCEQRDDFQKRRCEGESLDDYADRMFDRFLRSKKINLLDIPHSHMKVRVKRLTLFRGRHGSSARLKLYPEDEETVEDNSLWPENVTWRRWVSKQEWEREREESRQRRRDHLRHQPYRPYHRYDASYNKRQHRVEDTSSRDNDRNSPWYSDRDDYHDVDEWDPSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0E2</accession>
    <name>A0ABY7G0E2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="88" mass="10041" checksum="9B17E9FCB3A19100" modified="2025-10-08" version="1">MQCRKPYGPKLKKCAVGDTFLGLFIIQQNKSLIPGDREFLNNLPFDKMVRDVCPTGMKFGLPDLKWYFSFGKTVNCAGQDVFSKYIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2L8</accession>
    <name>A0ABY7G2L8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_013343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="105"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR27639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="172" mass="19160" checksum="EDB20C18D2514F4C" modified="2025-10-08" version="1" fragment="single">NCDLTIDATHKKSGVYALAITIEDKPTSTITIGSTTIKSFSLLDPPTNVRQSALRNDDMFRPDVYAMDLTWTPLHADKGSKTICVEATDNFLMSTQHCVTLVVWDNNPCDSSPCKHNGTCDRQGYKDNYKCACVPGFTGHDCKIALTNDDFRLAGNTYCRQYHLFGLDMCFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3V1</accession>
    <name>A0ABY7G3V1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_002678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001">
        <property type="entry name" value="OS01G0253100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001:SF931">
        <property type="entry name" value="OS11G0664100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine-threonine/tyrosine-protein kinase catalytic" evidence="3">
        <location>
            <begin position="79"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR29110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="358" mass="41440" checksum="BA6E15FDAE5B352D" modified="2025-10-08" version="1">MDEYLAFNGKAGKLDERVFSKLKLLCRPVKVAEDNAQQCNENTLVSKGDVPLYDTHLVIRTVEKPWAGDLYEEEIENKLEQRILHYAIVPQVAYYRNEQTVSFVAPYFGRGTLDKVIQKERETTADIKTEIPSERKPERATEIPQTLEWKDKFRILYQICRAIEYLHQPPTCERKHVSHGNICMQNVLLDAQTNARLLFLSPKSVEGGVGDEQFQDDKNKDAVTMTDIKTELKLYIRSEGINWWTPSQDDGEKKDKCEICCVNKPEKTFDKLTHDRYCVYKIQLCVGCLWNWRYNPVKCHTCDQDKIRSPVGDGWGAILIAGIDDKDTNTKLFEKDIDKIKDRVITEATMMGVRCLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G402</accession>
    <name>A0ABY7G402_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="112" mass="12199" checksum="B10E7B53B09117F9" modified="2025-10-08" version="1">MYLSGDPRPPFDCALQKASTQEFKFCIDIVTSNTGDDASEKEIKCERKKCVDTYIEGNKESPQCGLNASIQYRWSVIMAGGAIEVSDSVCGASGLFISAVLLFAALLVTRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5R4</accession>
    <name>A0ABY7G5R4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003350</name>
        <name evidence="4" type="ORF">MAR_003393</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045034280" evidence="2">
        <location>
            <begin position="20"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR29782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR29825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="197" mass="21906" checksum="493649B87A163765" modified="2025-10-08" version="1">MSIILNLVILAMVVQVSQAASLTFEWESLQVTKDTQACVIAKAVHNAMEVKLVASRHVLVKGKITNNTDVSFCVNHVMKHPDIKSIKQKTFNEAFGCFKIPNKVDEMQAFDSLDSEDIDVVTEYPDSDDNDVVTEYPDSDDIDTVTDSLGSDDEDAESATLELDAFSPFETEDNHPSARLLKAMLTFLKDLKEKKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G825</accession>
    <name>A0ABY7G825_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_033115</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea cycle; (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="10">
        <location>
            <begin position="229"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR30573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="298" mass="33522" checksum="66CCDF99E10615F5" modified="2025-10-08" version="1">MAEKKVVLAYSGGLDTSCILVWLLEKGYDVIAFLADVGQNEDFEAARQKAAKLGALKMIIPDVRSEFVREFIWPSIQANGLYEDRYPLGTALARPCIGRAMIKVARDEGARYVAHGATGKGNDQIRFELSAYALHSSIEVIAPWRMPEFYQRFPGRNELFEYAKEKGIPLPVTPKSPWSMDANLMHISYESGILEDPNTHAPSELYQMTSDPQVAPDTPTILDIEFENGIYETPGGAILLAAHVDLEEVRKIKRGLDEKFAEQVYRGFWFSPECEFTRKCIAQSQEYVTGNVTKRCID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G957</accession>
    <name>A0ABY7G957_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_033482</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF14">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="74"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="165"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR30940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="779" mass="89489" checksum="9F504D3900D4187A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9I4</accession>
    <name>A0ABY7G9I4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFC" evidence="2">
        <location>
            <begin position="357"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR30009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="431" mass="46349" checksum="6F60F645BFD8661F" modified="2025-10-08" version="1">MGKFPEVEMFAKMPHDFCLRTVSTRHVRTSLLYLKAADYPAQRGPICYNCQNPTPSGRFHDIEFCEQNKMELRPRDQTNTGDCCSTIQCTGNTGTFTSSQTITGTIGGNPAPQPGGTATGNPGSMITGALSVILVYYDRRCPTFGTLPTGCSLRSNPNDPCCQQPVCPVGTVTSNGQPVVIVPTYGNAFTGRTGAAFTGRTGAAFTGRTGAAFTGYGQPVMPQAGTQTSGMNTTPSPGSGGTGTVITGSGRGCVYKSNKWRLATWDDGCQYRCECLDPTAGQYRCTERCPAYVNLPPQCSLQTDPHDHCCKTVHCDYNMVVTTPAPIFAVTTPPTGDALCHYKGLYYRQGESWYDGCGLQCRCEDALNHYYQCTDRCPKYTNVPSTCTFVADPKDPQCCRVPQCQNAGGNEQRDLLAPSPDMATQPASHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAF3</accession>
    <name>A0ABY7GAF3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SC5AC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_033944</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="554"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR31402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="675" mass="73026" checksum="F61128B73B181917" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAI4</accession>
    <name>A0ABY7GAI4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DYN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_032896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin GTPase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR30354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="391" mass="44198" checksum="23F20FD96925EDEF" modified="2025-10-08" version="1">MSGNVGMEQLIPIVNKLQDAFASLGVPISLDLPQIAVVGSQSAGKKHAEFLHQKGKKYVDFEQVRKEIEAETDRVTGGNKGISNIPINLRVYSPNVLNLTLIDLPGMTKVPVGDQPIDIEQQIRGMLMEFIVKDSCLILAVSPANTDLANSDALKIAKEVDPGGYIGVVNRSQKDIAGQKDIRAALAAERKYFLSHPSYRHMADRMGTPYLQRVLNQQLTNHIRDTLPNLRNRLQTQLIDLEKDVEEFKNFRPDDPARKTKSMMQMVQQFGTDFEKNIEGSGAQINMKELWNLMKKSFVEKSATPLKTFAVSERACSLQIWLLKPFAQQKSDPSTTKRKVGNQVIRKGWLTLHNISFMKGGSKEFWFVTHTLLVTHTLPLKCYKTWYILYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAP5</accession>
    <name>A0ABY7GAP5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_003629</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF41">
        <property type="entry name" value="CHITIN SYNTHASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR30061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="612" mass="68590" checksum="5BA86608689AF80B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GC28</accession>
    <name>A0ABY7GC28_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MTR1A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_034505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="51"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="169"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR31963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="314" mass="35916" checksum="12E5F2C0F7FA688A" modified="2025-10-08" version="1">MENITYANVSVQMNTASDGSLGRHAFLTSQPYVAVSCIIIQAVASLAGTFGNVLILFVIATKSELRNKMESTFIANLALSDMYVTLIAGPMSLLDRRQSLHDILRDITNDDFNYEYKQVLLHMRKCFLQQNLYQEKLYRHVLYFVGTALVLLNTLGIGDHGFDQKSLECIWDRMATYPYTIVFSIVLVWIPSIISGINYLRIYLFVRAHRQKLIKNSIYSIGNMTQLKSVQLAKTLFIIYAVFVTCWAPYALLIVVDTKDTFPHEVHIYITTFAHLHPSLNWVIYFCTNKQFAKAYREIFTSCCRALPLSPTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GC92</accession>
    <name>A0ABY7GC92_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein C10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_034237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0456 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026317">
        <property type="entry name" value="P_C10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13463">
        <property type="entry name" value="PROTEIN C10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13463:SF3">
        <property type="entry name" value="PROTEIN C10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14974">
        <property type="entry name" value="P_C10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR31695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="98" mass="10940" checksum="C2EC07C16B26E978" modified="2025-10-08" version="1">MAASLQHFSLHECKVALQDILRAFREPDNVSRLDEARENAGNDMLRAMQTVFPVASQIQMEAVKVYEKQDPDVAQMNSQLRSILIPPVRAQGMVSNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GCX4</accession>
    <name>A0ABY7GCX4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046998305" description="Secreted protein" evidence="1">
        <location>
            <begin position="36"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10600" checksum="5213663942654F29" modified="2025-10-08" version="1">MNKCAKRTMLIEMGGKLNLVCVLWLNATVLKICEAESCTFLSLGKSCHFVLYQDLLLSKMIVFTDKFNILTKIIGQKWKVTREIVFYYASLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GEE2</accession>
    <name>A0ABY7GEE2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="77" mass="9100" checksum="7F25C375CC801002" modified="2025-10-08" version="1" fragment="single">VASNYPVDSFKIQLYTRTTTDKLQKARRRTWSWYKTCTGTSWSFLIDFTMCQHIPSQFRLDESENSTSQPVLFNLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GEJ0</accession>
    <name>A0ABY7GEJ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="123" mass="13138" checksum="E31D56B7B385E3B6" modified="2025-10-08" version="1">MFSGKTHTPEHLRAASSAYSSSGRSTSPNGRFDQTAQPTSLVPQGGFAYQAHENTPEVANGRRTSPKPHRRIHQPSSTATNSATAGSSSSNSPVNSKNGPKYPKITKLVKERRSLDRACAVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D7W7</accession>
    <name>A0ABY7D7W7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ACHA9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_006237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045936833" evidence="2">
        <location>
            <begin position="23"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="3">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ93766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="125" mass="13644" checksum="C45D8D5D99691278" modified="2025-10-08" version="1" fragment="single">MFLPCLLITLVALLRFYIPSDSGEKVTMGITTLLSMTVFMMLVAENMPPTSNVLPLIGIYYGITIFIASNATGMAVVTLNIHHKGNSGHEVPSAIKTICFGVFSNLFCMSLEIPQHARTQFESTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D9G5</accession>
    <name>A0ABY7D9G5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NOTCH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_006760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051830">
        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033:SF151">
        <property type="entry name" value="NOTCH 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="43"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ94289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="763" mass="86130" checksum="7E54CECE2026A061" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DD79</accession>
    <name>A0ABY7DD79_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027900</name>
        <name evidence="3" type="ORF">MAR_027949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ95259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="80" mass="9225" checksum="A075E260D59ED428" modified="2025-10-08" version="1" fragment="single">GDKNIDDKSVSFLDTKAIIYYCALWTLKLNVTKTKPVVFSRGKLRNKPSFYHRVVLRLLITLIHVFNTMVFPILLNASEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDU8</accession>
    <name>A0ABY7DDU8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS4B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_006714</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121:SF9">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ94243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="585" mass="65623" checksum="8A6555963A03696C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFQ3</accession>
    <name>A0ABY7DFQ3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Beta-N-acetylhexosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-beta-glucosaminidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_028428</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004866">
        <property type="entry name" value="CHB/HEX_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004867">
        <property type="entry name" value="CHB_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF57">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03173">
        <property type="entry name" value="CHB_HEX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03174">
        <property type="entry name" value="CHB_HEX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SMART" id="SM01081">
        <property type="entry name" value="CHB_HEX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="Carbohydrate-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047509388" description="beta-N-acetylhexosaminidase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="domain" description="Chitobiase/beta-hexosaminidases N-terminal" evidence="9">
        <location>
            <begin position="37"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Chitobiase/beta-hexosaminidases N-terminal" evidence="9">
        <location>
            <begin position="823"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAQ95738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1646" mass="188241" checksum="E003232B888FB3F5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGJ4</accession>
    <name>A0ABY7DGJ4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_028145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1251"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1508"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="187"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="468"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1147"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1459"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1270"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1508"/>
            <end position="1519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ95455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1550" mass="181960" checksum="EFD48A8F05F6943F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGL4</accession>
    <name>A0ABY7DGL4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CAD23-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_028441</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF23">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046094072" evidence="11">
        <location>
            <begin position="23"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1661"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="29"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="144"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="226"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="325"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="440"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="540"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="655"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="762"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="885"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="964"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="1073"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="1212"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="1335"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1737"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1746"/>
            <end position="1761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAQ95751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1835" mass="204057" checksum="3437AA57AAD2C72D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHN0</accession>
    <name>A0ABY7DHN0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CC166-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_028816</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032777">
        <property type="entry name" value="DUF4515"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING 166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845:SF0">
        <property type="entry name" value="DUF4515 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14988">
        <property type="entry name" value="DUF4515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4515" evidence="4">
        <location>
            <begin position="86"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="115"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ96126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="314" mass="36468" checksum="2FAD1AE5FD7A50AD" modified="2025-10-08" version="1">MPPKKGKKGKKGKKGKKGKKGGKGAEDGGGEGGEGGAGEPSEKESLLRNELEKVTLELDTAKKNVEELRKENEWLQQEAQNVRVESHEYMSYMEKKTTKRQTTIITLSDHNKHEIRNIQLQQEIMEEEFNDKENELKKMLLEKQNLLTKTTQELGELGSYKKLQTEQLNSIKNLEKEVMKLRSKHSETIQQLKSQFLRDKREYQQDSENKISTLQRKANKEAIMCLTDHTNNIKLENRQLRKELLELIHKTRALQDHKLELEDQRRQLIREQQYSEDLKKLRTTRQHKVFKSFGMLGEGDNPEDDQSVTGSAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIH0</accession>
    <name>A0ABY7DIH0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WBP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="204" mass="22222" checksum="908B4777057C358C" modified="2025-10-08" version="1">MSINTAHANGGVLIFTGERILLYCDNVEMGFEPNTVIFCNKNKKDMLQSFSLPFLQMRGVELEQPVFGANYIKGKMLDEAGASRNRPAQPPPYSPPQGPFYQAPPPAYSAPHTEYYAWVPYQTFPTAPPPEYVYTTGAPPPYPGVDPAYPPPQPVANGTSSADAKAMEAAASGYYNPANPHNVYTPAPYPSAPPSYDDVTKKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKM7</accession>
    <name>A0ABY7DKM7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43564:SF2">
        <property type="entry name" value="BLR6059 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43564">
        <property type="entry name" value="KYNURENINE FORMAMIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18740" checksum="3B8DAC630B8974DB" modified="2025-10-08" version="1">MEIFEHQGTHIDAPLHFPNGRQDLTQIPPEHLYGPGVVIDVWDKAAANPDYAVTVQDILERKEFGRIPVGALVMMNSGWQFKYPDARRVFGLDNIQDPSERDRSGHSVHRPRQFARLCHNLLQPNNMSLLEYVANLDAIPRTGTTIVLGIRLRFGTARAAPHGNSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKU6</accession>
    <name>A0ABY7DKU6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GET4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_030198</name>
        <name evidence="4" type="ORF">MAR_030277</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ97587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="327" mass="36964" checksum="57536B8B7C097F70" modified="2025-10-08" version="1">MAAGTQRVLAKCQKCIDSGDFYEAHQMLRTLYFRYSAAKKYAEAIDLLYNGSLTLLKHKQYGSGSDLALLMVEVLNTANTPVSDDITDKVVDLLRIMENENQERHTYLNNALRWTIKVEPDHRAGHPDMHKKCGLLFWQEKNYVQARYHYLHSFDGKNLATMLVEYHTALGYPSEVDLFIAQTVLQFLCLKNKDTAHVVFTTYTKQHPEVEQGPPYIKPLLNFIWFLLLALESGKLAVFVVLCEKYQTSISRDPSYREYLDRIGQLFFGVPPPKSQSQSGFFGNLIQSLLGGDDDEAGPSFSPAQTPAVTPGTPASENRNMAPVELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DM06</accession>
    <name>A0ABY7DM06_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NOTC2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_023065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF35">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="190"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="229"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="268"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="307"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="346"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ98692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="467" mass="51186" checksum="754360D42ED887D6" modified="2025-10-08" version="1" fragment="single">ILTCVPHLLLVITMGRVKTWTVTTDATALMDGADKTAAKILTCVPHLLLVITMGRVKTWTVTTDATVLMDGADKTAAKLLLCVYCHIVAVHFKQILTSVSHYHHILTYVPHLLLVITMGRVKTWTVTTDATALMDGTDKTATKILTSVPHWLLVITEELVKTWTVTTDATALMDGAVKTAAKLLLRITTDIDECTTMAPCYNGGTCENLDGNYRCNCPDGWSGQNCRQDIDECVTLSSCKFNGTCENLNGSYSCICPQGWSGQNCSQDIDECITLDPCFNGGTCVNLDGSYICNCPQGWRGENCSQDIDECATMAPCYNDGTCENLDGYYRCNCPNGWNGQNCSQDIDECTTLAPCYNDGTCENLDGYYRCNCPNGWNGQNCSQGTIFSFNPNRAVHNIKRLNIVCMIDQTIAEHVTQILTSVPHWLLVITVGHVKTWTGSTDVIAFKDGADKTAVKVQPLFLHNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPV2</accession>
    <name>A0ABY7DPV2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_022974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ98601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="62" mass="7299" checksum="565572A675822F2E" modified="2025-10-08" version="1">MFRKCYYLTQPAQKDVLARIAPRLVVIVWVRRYVIMYQETVLLADVSGDSTVPDVKQTFHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPX0</accession>
    <name>A0ABY7DPX0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SVEP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_022516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF4">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="110"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="218"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="334"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="444"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="505"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="612"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="723"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="848"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="956"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1015"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1119"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1172"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1281"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1339"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1392"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1470"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="640"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="876"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="984"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1040"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1141"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1197"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1420"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1476"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ98143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1503" mass="152801" checksum="ADF6CE93139A8273" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSL3</accession>
    <name>A0ABY7DSL3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="701" mass="80084" checksum="13FE8251EA37DF95" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWA1</accession>
    <name>A0ABY7DWA1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MCTP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_025310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd04042">
        <property type="entry name" value="C2A_MCTP_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08376">
        <property type="entry name" value="C2B_MCTP_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08377">
        <property type="entry name" value="C2C_MCTP_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911:SF4">
        <property type="entry name" value="MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="828"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="212"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="367"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="516"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR00938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="930" mass="106419" checksum="7C1E09D0DE4F72F9" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWX9</accession>
    <name>A0ABY7DWX9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DOC2B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_007706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd15746">
        <property type="entry name" value="FYVE_RP3A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041282">
        <property type="entry name" value="FYVE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030541">
        <property type="entry name" value="FYVE_RBF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043566">
        <property type="entry name" value="Rabphilin/DOC2/Noc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45729">
        <property type="entry name" value="RABPHILIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45729:SF6">
        <property type="entry name" value="RABPHILIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02318">
        <property type="entry name" value="FYVE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="272"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="405"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR01148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="536" mass="60123" checksum="F76AB7F2DC92F962" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWY3</accession>
    <name>A0ABY7DWY3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SPIN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_008800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd17328">
        <property type="entry name" value="MFS_spinster_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF79">
        <property type="entry name" value="PROTEIN SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR02242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="346" mass="37511" checksum="FAE167B169BB016D" modified="2025-10-08" version="1">MSNYDSNLTPPFDDSVQLSEMQVDVSDDLPIDAAGGDMELPEVEIVENTNHISTKRGYVIVAILFFINLLNYMDRFTIAVFLGFHPDAGYGWSGGGQLLDHRSHSHRRPVYWWAEDKDANGLLLCHSSWQVTPLLGIVCVGLILILVREPVRGGADGAHHLVNTSFFTDLKEIAKNKSFMLSSFGFTCVAFTVGALALWAPIFMQDAMSVLGHPTKASTVSFIFGGITVAAGFIGVAIGAESSRRYKLINPRADPLICAMGLLVLIFFGEVALCLNWAIIADILLYVVIPTRRSTAEAVQILMSHLLGDAGSPYLIGVMADGLSKGYKGNPSSPAIQFVALQQSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYG9</accession>
    <name>A0ABY7DYG9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GA2L1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_008622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756:SF18">
        <property type="entry name" value="GAS2-LIKE PROTEIN PICKLED EGGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="5">
        <location>
            <begin position="19"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR02064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="307" mass="32612" checksum="E978656D5E4D11B1" modified="2025-10-08" version="1">MGCLHLELGALDYTVNEFDDESNLEIQVRELVGRCTCPRQFPIVKVGEGKYKIGDNQTLVFVRILRKHVMIRVGGGWDTLEHYLDRHDPCRCGFQGHRGGAKTPGTPRRASTPATPKSASTSKSAPNTPKTPRKLSMTAPVSLNNTHSGSTARPASPRMRSASPGPKVLSLTTKNSVPQPGLSVTSPVISNKQPSFTNSGGGTKVSQNGVSTSGGYSKGSFVKQSQANLTRQTSTSSIGSQPGTTPRGSSPGPRRSESPAPVIAARLRSPSPGPTPKKKPGVVRPQSVPATQRCQSPVKQITMSELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0H2</accession>
    <name>A0ABY7E0H2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB6A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="25"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="259" mass="29327" checksum="3706D093E18178A7" modified="2025-10-08" version="1">MSDPWQHEESFAVTNAHMLSDDILCDVNILAGEERQEVRCHRFMLASRSPVFYTMFCGSLPEEGVVKIPDVEADVLRTVVSHFVPFVRFMYTGEIQLMPESVMAVMYAANKYDIQPLINRCKTFLEKTIAIDNVCVILDQALKFAEDDLVQQCLSFVSKTTDQVFQSNGFLCMSSEALKLILEKEKETQNLPPEDVYASCRRWAKQACSSSGTEVTDQVLRQKLGDLICLVDFAGMSYESFTDNVVKETILSDKEKVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1P3</accession>
    <name>A0ABY7E1P3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_009687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR03129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="185" mass="21927" checksum="778DF2F5286EAEB4" modified="2025-10-08" version="1">MSQASTLFFNGSQTKTPYWTNNPPNVPKYPSSQEMFRFEQPDRFTVKTGRDSYQHWTDKWYDSGIPTLRREELPKIADRQEPCSQPWQYNLGTSAVDKWNKKGKDWPIHPMYSTQGLPPTETQRARGMNRLTIPRNDNLYPFSNYMTSTYRRPVYSVMGPMQRQPTYGVTHQHNRHGNMPFEDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E254</accession>
    <name>A0ABY7E254_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_019452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047548748" description="F5/8 type C domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR04083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="28864" checksum="8DA5EFA52BD7707C" modified="2025-10-08" version="1">MKGAIYILWLFQLYGKLHYADTAVVNLALGATTSQFDTLEYSGFTWDSDKAVDGCTLQDNPETQQCCAASLGTAENFWRVDLNTTYRVSRVMVYGRNDGQGIQQTGGFKLHVTDGSGQEEQVYDNNGMVYGNGVFDVRFVEPCADGMYGGDCEFTCGQCQGGAPCDKVTGVCSGGCQPGWETSTCNIASTTLPVIQTSTSGPSTNISPGSESSTMNSSPESGSSTINSPPGQGSTDSQNPSSGSSLTPSQTTGQGQSSTTSGTYTGNLIKFGLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E286</accession>
    <name>A0ABY7E286_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TRI37-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_009097</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd19779">
        <property type="entry name" value="Bbox2_TRIM37_C-VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16619">
        <property type="entry name" value="mRING-HC-C4C4_TRIM37_C-VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053003">
        <property type="entry name" value="TRIM_RBCC_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36754">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36754:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="106"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="637"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="640"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="681"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR02539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="734" mass="82620" checksum="38CD2C54179560F3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3F8</accession>
    <name>A0ABY7E3F8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S14L2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_010033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058960">
        <property type="entry name" value="Ctg-1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF83">
        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25883">
        <property type="entry name" value="F28H7_8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="75"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="256"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR03475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="400" mass="45159" checksum="2F90319227023682" modified="2025-10-08" version="1">MSGYVGDLSPKQENALQEFRKAVSDSIKPKHDDHYLLRWLRARDFDVKKAEKMHSEALEWRAALGADTILETYQEIPVIEKYRTGGVLGRDKSGCPIYIDPYGLIDIKGLLRSAKKIDLMRKFVHVMETVDKMCEEESKKCGRKVNALTVIYDLSGVGWNHISKPAADMYLTIVETAESKYPEVLKKVFVINSPKMFPVIWSVVRPFLHENTAKKVAVLAGNYQEALLKEIDADQLPMCYGGTLTDPDGDPRCRTHEYYNQAVPHSAMTCTTIGRGSTLQLEYEVHKPNSALRYEFLTEGYDVGFGVFRKSSRERLKAGDMETVLPTQRSNSHLVPEDGAVECDIPGIYVVRFDNTYSWARSKKLHYLIEVLEVSTRNSSSSSLSNQAEAAPTQEDICQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4S2</accession>
    <name>A0ABY7E4S2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Novel STAND NTPase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049050">
        <property type="entry name" value="nSTAND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20720">
        <property type="entry name" value="nSTAND3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Novel STAND NTPase 3" evidence="1">
        <location>
            <begin position="53"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="113" mass="12741" checksum="C4AEA2197FE86F6B" modified="2025-10-08" version="1" fragment="single">AMVVLGKSCGLNNVNSEIEDLVTKTLNLVTPEMKNLRENTIWFFGESCNDAFYVETARFQDAIRLLKEKHFIVLTGHPGEGKTAMAARLALADGTKPENCLKLERSRDWRKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E538</accession>
    <name>A0ABY7E538_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR04060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="235" mass="25899" checksum="C5990C072BE4F097" modified="2025-10-08" version="1">MGTLQASQQTNDSYVMFMFQLFQKGMIFSALVAGVICCGHLVFVRRKYCRNTTTLFAVVLSGFLHLIASVCMLTIAEKNTEIRVEDGPPSVGSCFDYSMTAVCANTVVLLAIIHNVFVQNFKWLVSSCLAYAGILGCVITGSFFVIKRMPQNSSFPVAQTTLVTLGASRSQHMNVFLSVCQKNVNEERWAIFAEYMLIYVPVIVTVLTALCMNRTKQTVQSSTGYLCKRGASTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5J0</accession>
    <name>A0ABY7E5J0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PHO23-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_019590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF3">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR04221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="270" mass="31190" checksum="8C314339158F2638" modified="2025-10-08" version="1">MRKKKQEVRQSKAVNSINKTSPPQNSIKEICYPSEKYVQTNATKWGCDHEKDALQKFMEEIGPLHENSRLQNSGFVISQDVSFIVASPDRIFICDYCGPACVERKDGELIKFKHNLVFQNMNSVTLLCGQQTTCMLKQTCSTLNYWTRFVPVQNILCMRQFFKNLFYTRLQTANSLPIGILHSVENTTSSQNIQPLKKCSNKQDSTVEVYCYCCQVEHGKMIGCDNEACEIEWFHCRRVSIENAPKGKLYCPDCRKLPCFKQKRLKQNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E746</accession>
    <name>A0ABY7E746_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_021239</name>
        <name evidence="9" type="ORF">MAR_027571</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF157">
        <property type="entry name" value="DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="36"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="237"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR05870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR13391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="458" mass="51139" checksum="7D79BB8D9B41605E" modified="2025-10-08" version="1">MNVGAIFKMAIPMAIRKVVGEMEFITALKHNQMEILMEILNGNDCFAILPTGYGKSLPYQMFLPVKRALNPENHDTVLVCCPLISLMEDQVRRVQQFGVTAALRGTDQDANEAIDDGTISVIFASPEALAEEWVRQIKDVSLIVVDECHTISMGGLDVDEEKAFRKYFRFIGTLRSIFPDATVLALSATCTLKMKTQIMSNLNLSGKARVIETSPNRANIKYVVKRTPIAIEETFFWLIDKLCELKKDFPRILIYCNSIKDVCQLFNYVVTETNLMDQNVVEMYHSETPQEKKEHIVQNLGLDSQMKVVIATTALGLGVDVKNCHGVILFGPPKDVVDLLQESGRCGRNDEPSVCVIFCNRYQLNHISKEVKEVIGSVECRRRCLLKNFTSEEVVSDPAHMCCDLCVSHCNCGSCTPHPIEVLVGTFSAKAEDALVSSDSDTISYEYESDVSFDGGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7A9</accession>
    <name>A0ABY7E7A9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DC2I1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042505">
        <property type="entry name" value="DYNC2I1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16022:SF0">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 INTERMEDIATE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16022">
        <property type="entry name" value="WD REPEAT DOMAIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="822" mass="96816" checksum="44289EBEBE8B53AD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7F7</accession>
    <name>A0ABY7E7F7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="111" mass="12477" checksum="319AB788736312B7" modified="2025-10-08" version="1">MICFMDSKIIVWTYLYFATSSKIGVSPDYDKIQRENRRQCTRKSSAYDVIELPEFPKTRPEKVQPVVTPRVEAVSTDEEKHSNDESASASSCGHILTVGWLMSFGVALGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8X5</accession>
    <name>A0ABY7E8X5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="85" mass="9661" checksum="81D47FE94D1D84E6" modified="2025-10-08" version="1">MDRNGTDIQAVIGLTDCLLASKAFPKRGFYIFDKTCLVVILETISTVILIKKYRFKMDFICNTKAVYTDMLICKICTFSNGNVYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EA59</accession>
    <name>A0ABY7EA59_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NGB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_016841</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="8">
        <location>
            <begin position="22"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR06883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="187" mass="22195" checksum="F4B3113DE5BFE2AC" modified="2025-10-08" version="1">MGCENSKSDSNDEDEIQEHEDEFNENRVDSIKSTWPILTRDRMQTGSNLFRHIFLVEPRIKALFKRDRSMTDEEVLHSIEFKHHVERFMHSMDQVVENIDKDRDNVEHMLLILGAKHATYDGFKEDYFSVYANCMIDTWESVIGEEFIKEVRESWELLVAYVISRETRQILHLIIKQDSSKEYDSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAS7</accession>
    <name>A0ABY7EAS7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NPHN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_021588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="151"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR06219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="317" mass="34630" checksum="F617A3F14698BE76" modified="2025-10-08" version="1">MRINNVSNASVEIEENTTNHIQCSLESDPASTIAILKDGKKMIESHGVHQLTHEIKPECSDTGVYTCSGYNEYGVAENASINLCTEESEGSCNRLSDKIPKIDIVTGNLSSSLTILDVKIEDYGMYHFSVHNDIGSPLIEMLQLKPPIAKPDPPSDFHVIQEEISETSAVLAWVPGFDNGSPQTFYITYGKKGGSSGWITKSVEHTYEAKINYTLRNLETETEYIASINASNEKGSTTTINDITFITLKHIPGVQTNFMTALIGGAVGGGIAVVLVIIGLVFLVKKMRISGNELTVVTKNNNDNVFFKNNNYSNNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBJ2</accession>
    <name>A0ABY7EBJ2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_017356</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR07398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="484" mass="55088" checksum="39F43D1D782280B1" modified="2025-10-08" version="1">MIIKCSVIGCSNRKDREKDLQYYRIPAVIKNQGDECERLSTNRRRQWLAQLGQSFENKNIDNVRICSAHFVKGKRADLYDQLNPDWIPTINLRGCATPKPPVHNDSTTPSTSRYNRQKDRIQRRLDMSQFATAELTDTGPMDEDSETPCSSTKTDINGQYIEGMKHEIEALQSQNQHLKSQLSDKFSEKDFEGNDEKVNHLTGLSSHETLMLVFEYLLPYLPSSFVMTQFKMLIMTLMRLRLNLSVMFLAYEFGVSQATVSRVFTNVMDCMFARLHPMVHWPQREVLQKTMPMQFRKNFGKKVVSIIDCFEVFIKKPSNLQASAETYSSYKHHHTVKFLIGITPQGTVSYISKGWGGRTSDKYITEHCGYLNKLSPGDLILADRGFDISTSVGSLAASVNIPAFTKGRDQLSAADIESTRKLANVRIHVERVIGTVRQKYSFLNGTVPIRFLMFKDENDFTVLDKIAHVCCALVNLNASVVGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EC40</accession>
    <name>A0ABY7EC40_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="71" mass="8177" checksum="AF2E22D485941604" modified="2025-10-08" version="1">MMMNAMTKPTCVTIIVQTRKGRIAAHVEQDTFWTLIIALVQRKAINAVLERTNVIVMLEEPDVHIPTQMWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECV8</accession>
    <name>A0ABY7ECV8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="156" mass="17351" checksum="513F24ACF44C003C" modified="2025-10-08" version="1">MYFLGDNSRRSFKVLLKPILIGSGAFVALCIFVGSANVNECAFVLYRVPDKTEVTPSAIETSPSLDTNVFVEIPETSIPMNASHDLIREETIMARKQTTAIESQHAESSLIYANLDIDHLQKAFVGPIRGPRPTIRKEATEYQDIDFYHTKPAGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDH9</accession>
    <name>A0ABY7EDH9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-1,4-galactosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_017172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyses the transfer of galactose onto proteins or lipids.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="3">
        <location>
            <begin position="117"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR07214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="383" mass="44621" checksum="3D7ED72076EFB1D3" modified="2025-10-08" version="1">MNVLQMAFVSDCPCKGRKYLNQCFDDDDDDDDDDDDDDDDDEMMMMMIMKMMMKVMMIMMMTMLLLLLLLLLLLLLLLLLLREMIRKFVHLVKNKVTSMARMKLKVFVTNTHVCFSVGNLSISFEAAHRSVLLTAFQDVSPGGAWRPNSCVARQRIAIIIPFRDRQEHLDILVYYLVPLLKRQKVAFRIFVVEQFGNKTFNRGRLMNIGFMEARKNEEFDCFIFHDVDLIPEDDRNMYTCLEKPRHILPYKALVGGVLSMKAEHFFKINGFSNLYWGWGAEDDDMFYRFKLLKTAKTRYLKEGLNTLEYRLVETRLEKLYTCITVDIGVPPKNQTEYPIANVGDPPKNQIEYPKVDVGDPPKNKIKYPKADVGDPPKNQTEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EF46</accession>
    <name>A0ABY7EF46_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17265" checksum="7E3B1BD70D475800" modified="2025-10-08" version="1">MTERSEYLVLTADEIDQKIVYEIILTGLNDGSTYEVILFSRNEKGNCKQNTSLRFDTEVLVESPPGTIGSIVGGTTGGIMAAIILVIVVVIVLRRKYNFDCLCSFRVSRKDLHHDANTDNGIDTQGANNRGYNATQTYEDISMVTDKSLYDAMGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EF78</accession>
    <name>A0ABY7EF78_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="114" mass="13075" checksum="6E2ACF702B0D3890" modified="2025-10-08" version="1">MIDKNLNSLRRCDTLSSSSHPSDLDLAADATHWARVHIPGTLTLQQMKHIELEYTSHRDSPRLKLNVINSDNRKTHWIIFGEFLLVAMTIVVDTDEAYSAVYGMRQQLLKRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EG87</accession>
    <name>A0ABY7EG87_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SVEP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_017631</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050350">
        <property type="entry name" value="Compl-Cell_Adhes-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325">
        <property type="entry name" value="COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325:SF575">
        <property type="entry name" value="LOCOMOTION-RELATED PROTEIN HIKARU GENKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="17"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="75"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="133"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR07673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="236" mass="25351" checksum="B590F793CBA6F9C1" modified="2025-10-08" version="1" fragment="single">MPQQDNNETTVLLARGKNCGNVTNPINGSVTYVETTYDETANYSCDTGYNLSGNMSRTCQAHGDWSGEAPSCIIVDCGNVTNPINGSVTYVETTYDETANYSCDTGYNLSGNMSRTCQASGNWSEEAPSCIIVDCGNVTNPINGSVTYLKTTYDETANYSCDTGYNLSGNMSRTCQASGNWSEEAPSCIIVDCGNVTNPINGSVTHVETTYNETTHYSCDTGYNLHGNISRTCQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGL9</accession>
    <name>A0ABY7EGL9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="87" mass="9661" checksum="0E0D411707F52876" modified="2025-10-08" version="1">MAVDGCILYIAMMKATIKEILCYLLLPLVANTVSGEVNLTASGSFIDNTYVVKTGSSIPLFQYAKMARAKKDRREDAENQDEQRKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGP0</accession>
    <name>A0ABY7EGP0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BIR7B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="338" mass="38194" checksum="6E0C942205702CF8" modified="2025-10-08" version="1">MFNKLQWYVNDDLCSYKVDLSKKQLTELPFEYDTPDNICHYGDYILGENKSSDTTTVKNKILDLVVPLKGIEIYAFPCLKSYFNQLALPTNSYKNIIYNDGELLPNPPQWRPGIKHGGVENAHEQNNISTLESARTNDISRSKRRRPRYPGKCTMESRLDTFTTWSHSAPTPQTLAADGFFFTGDADFVRCHQCGIELKDFSPFGDPLSEHIKHAGSCDFLTDLYGITGLEQKRIEQTDDPSSRAMRPAWTHLMVGRKMCLRSRTSLQTLVCTSQVLKIMCGVLHVTEDCGSGMRETTLGWSTADGFRPVTSQGHLRGTNISNAFRLPSTKGRTCQNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHZ6</accession>
    <name>A0ABY7EHZ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="791" mass="86988" checksum="9C9B5805908158DF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EI83</accession>
    <name>A0ABY7EI83_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_018469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR08511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="198" mass="21484" checksum="FB2EA4CCC0E7C7E0" modified="2025-10-08" version="1">MGFKYLIVLVVLFVLLNPTECWLVKKLIKKIGKGIKKVVKKIKKVGCKVLFGVACPAVVGAAGTALGAGSGGIAGLVAGAAVIAGASACYVRQTKCKRSVENGMALLPFSDDFRDYDMNDDKRIEYEEFVYTVMRSVGLSEPMELREPFNIADFNGDGELNSKEFEGAPFLFAHANFHQFMKKEVPETSPSFEVSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKG0</accession>
    <name>A0ABY7EKG0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 181</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_019214</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Interacts with HOOK1. Interacts with HOOK2. Interacts with HOOK3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
            <location evidence="2">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CCDC181 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026687">
        <property type="entry name" value="CCDC181"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14320">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14320:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="287"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR09256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="477" mass="55591" checksum="00B09541FE869BDB" modified="2025-10-08" version="1">METSTDPNELDDFEKELNSYIESEEKSKSEKQTSTPGGQSTMDRGVVRDTSDNEDSEIDDYNLTEDQKRALEELDNLKTEMGYPDEDPPEYDVKERLKVLNEDLKNDPTPLEKQKDSKVGFKADLVDLVAPPPDYGEESGTEENASAAGKSKPQQKQSDDKVDDKSETIVDTKKSNPGKKDSVLIEIDGQFQLVDSDDVRAKDFLAMNPDGNKENKENDKRNDKSDKSKPLQPIPPGKPRPATASASSRRNIRTVPQKERPSSAHASIEHRSALQDFNYNSPYALSPREKQLMEERKKAMEKQKQQDERKKRDDDEQKERENREAFEAWLKKKRESDRRKNIHDEDDRRQNEKEDRSADSEDGSVETEDWKKEKEEAFQNWLKEKTSQFKKEKLLKRRQEQEMHDGYFIRSRDDCEKAYKQWLKHKAMEARKARAAERQKAKLQRLAARRARKSISLSKSIRESNSFRYVDYYGYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKR4</accession>
    <name>A0ABY7EKR4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SNIP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd22718">
        <property type="entry name" value="FHA_SNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="256"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="360" mass="42583" checksum="40AA95365132142A" modified="2025-10-08" version="1">MVKSHSYSSSEEDSEHTHKKKHSKKRHKESKRKRQHDSSPGEQDERKLKIKAEPVSDDDFGVESRSRVKHERHRATKREHADSDDERYSRQQMKEEESTGTSRHRDGHRGGRRERDRGQHYDRHSHHGHVRVKQEPPDSDEEMRNQREERRGHDQRRRENRQRREEMPESQRFGRGATQAEVGRDTQEGATGQDNNDAPNFELSGKLTEDTNTYKGVVIKYNEPPEARKPKKRWRLYPFKNDEPLKPFHMHRQSAFLFGRDRIVADIPVDHPSCSKQHAVFQYRMVPYEKPDGRKAYRIAPYIIDLDSANGTFVNNKQIEGRRYFELFEKDVIKFGFSSREYVLLHDKSNTDEVASDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELJ3</accession>
    <name>A0ABY7ELJ3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="227" mass="25785" checksum="163D52CCBAB74B62" modified="2025-10-08" version="1">MVSNDKLLIYVDADLKSRFMKSESYTVDMVAPQYIRLDVDFQNLYQKNQSYKIEIVQRRTVRYALNRFHYTRSGNSILNEFCWETPKSGMVKLQLTGSKSTTILLITLINGQHPRQDQSTSSASTYHLRINSSSASRGLYSSGMDNQPQWPRLPPWYFSRGSSPPSPSNGDRQQLKDPSQVLSCADGYSSMASPCKSERLIFQSHCCGVTKSLKYNNIFKIIVLIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELZ9</accession>
    <name>A0ABY7ELZ9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="13141" checksum="8C50BB488FD0E5B3" modified="2025-10-08" version="1" fragment="single">MIKNKLHHAKILADRQAREIADQKRHMTKLKQEIADTNKALEEALEKNRQIKLKVVGLNSKILFLEGQIKEMNQIPTTPPPPPTPPTPPEPEIVYVKVVDSSIELQLHEVQEELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EM57</accession>
    <name>A0ABY7EM57_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="182" mass="20636" checksum="DE76E3D3E382BBEA" modified="2025-10-08" version="1" fragment="single">GEQGETKCSLQDTVLLVKLSTWELVSQDAVYHLKCYRSLFHKAWDENANDIIYYSNAVILVKAANIVREDIFDKKSECFVGSFENACQDKSGQIATDNVMETHATYTLSQLVKFNTIQRCRSSSNAPFQKDYMLKLEIGALWIMKQHGASISYNRVLELSTVLGNNAIKVYESQNVVCPQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EN13</accession>
    <name>A0ABY7EN13_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="24167" checksum="CAA87D7BDE12B13C" modified="2025-10-08" version="1">MLGIKLHRPNLNVNDNTRICSLHFENRQCVRSESVPKYYNLGKTKVNLDSRLRRPLFKQPEREVFFARKIDNYGLPETFEDRLENCATIEVEDTKLCYREETIQINASEHGYSKKREFATTEESSTQTDTSQTSGGYKPEDIIACNDGNTRFYKGFPTYAVFMLFFQTFIKHGADRLTYWEGQKRTLQDKSQKELPSKPGRKRKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EN82</accession>
    <name>A0ABY7EN82_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N4BP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_035352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1740.10">
        <property type="entry name" value="2',3'-cyclic nucleotide 3'-phosphodiesterase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008431">
        <property type="entry name" value="CNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10156">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10156:SF0">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045976053" evidence="2">
        <location>
            <begin position="18"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR10276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="461" mass="51574" checksum="57D16F3A148296F5" modified="2025-10-08" version="1">MIILLLESLWILKEVMTYFGIRRFIDLPDVSSDEDDGLVFVKHGTIETSVILINSDEAGEDVVVISDDVVNTGGQKQKEKDVFIDLSDKDDTDSIKKETTEVFYATRISNTESANINSSIITDGAASNVVTPKDVIIINDDDDNETVGLPSTEPQPSTSNEKELDAAGRVLWSAAFSNFTLHHWDQNKLSDAHQYCQTLATQTCDQKCPVVIIDNTNIQRWTMAHYVKLAQTSHYYHIIIVEPETPWRYDPDILAARNSHGVTKDIIAKKLQSLRDNKCLPYYYGRRAICARVDLYWENDEITAVGQDGGNKANFETASSSKKQNTGGLVKHNNSEVPGEVNQNDKDIDDMLNLFVKPEEEDLRSKYEGQKRGVGYNDRQRLLKHGCSAHVTISYAKTGQARHSGDDVLRIVEMDFNGQNIGTAETSIGKVVGYGGEMCAVTLKRPVTLDSLFQGFYSMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENN8</accession>
    <name>A0ABY7ENN8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADA17-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_025640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="3">
        <location>
            <begin position="228"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR11460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="306" mass="33787" checksum="27AB3E987E0C683C" modified="2025-10-08" version="1">MEATEVNDVEIINTGGGIKIMLNTGAYELLKVSAEHFYASENDTFQFQKIPVTDKKGNIVETKFKVSSGIQPPGLSTNVELVKISGAKIRDVAQRLNEIDTRHYNDVIIHVGGNDVSDGKQPDASYREILNVTQKLQEQRCKVHLCTVFPRRDADVSEFNSRVRQVSRETGADLIDCYQAFVYGNGDTVILYFTRDGIHLTEQGSRTLVATTNNFDVCLVSPVVARGEQLCGNGRMDAGEECDGGFLGMVNQDTCCASDCTLRPGAFCSFLHCIESFKTNMVACVTGFSLILYVPICIIIWCVVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPW4</accession>
    <name>A0ABY7EPW4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="295" mass="33032" checksum="61ABBFD0F8BD6BC6" modified="2025-10-08" version="1" fragment="single">DLCAGCLVDRGVGFTPLPGDCTKYVQCWRDGMDVRALVRSCPFGQYWDADAITCRPSFLVRCTADPCVYADSGFTYGIPEYGCRGYWKCIDGFSVGHCCPTGSAYVEGLGCLETASCVEDCPPKHGTALQPTCDRKPHWDKRYYIEIVYGRGEVVRPCPAGTVFYENKCECDFGLSGLQPANPELLCQPLASFPFNLDLEDKSLLGANVGVNGVRRTDLGTAYFNGNSNMNLWRFANADWGNQLVIKFKFRMAYSDQRVDYGRLPVDYGVEGDLSQIVTDHHMTDMDWRLWDQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQB4</accession>
    <name>A0ABY7EQB4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_036087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF26">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR11011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="465" mass="52574" checksum="D2A459E7C8D9E3D7" modified="2025-10-08" version="1">MGCVQSQHSTEDDGEYIETLTLRRQISKRNTGGPTQNLKISISVIADPMSSDDETAPSVMCNVHSVHKHSFNTVSHMEGRKYTKFPHMVGYKMCRACNKAREDVLNTVAPDGDEKEICRKCSVKKRKNSEKKKNLKNLNKKSLNMASVSQSLATKTLEVSNKIDITHFASLLALTALDLTAPASEAILKNRKNTWIQLAGHPGGFAPAGPNTIWKKRYTKDNNEAEAYEASPLKFDWESHWDEDGIPVGSHWENSSKITFLEAEVMNSTQRKDLYDKMVALDPDAPTAEEKRLQSITKLRYMQFREQESSTADYGFRIEAVRISGEPPTTNLKRVKTKEQIHDVLSRFVHNSQHIQGLLLERLRDIRDKLQESSFFMSHELIGSSVLVMYDQNGKCGIWVIDFSKTNPVPDAEPITHRLPWSLGNHEDGFLFGIDNLIQFFSDIEVKEEITANVCQSQAREEGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQX9</accession>
    <name>A0ABY7EQX9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein NATD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_036297</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NATD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PROTEIN NATD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435:SF9">
        <property type="entry name" value="PROTEIN NATD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="44"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR11221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="138" mass="16180" checksum="3226EE4187284EC1" modified="2025-10-08" version="1">MSMTRSILLISSWGKSFSKSHTACHHFKTHIAKMSTTVTNKDVIHDSSIREFYIPLKEEGFEGKAYLQYSFIKPDYVDLEHTVVPEHFQGRGIAKVLAKTVFDHFVDEQKYIRPTCTYLQKFYNDNPIPRYAEKVKWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERD4</accession>
    <name>A0ABY7ERD4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MYLK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_036045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14340">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14340:SF13">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="50"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR10969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="233" mass="25429" checksum="8D39C3450F8D87FE" modified="2025-10-08" version="1" fragment="single">MVTTSELFSTLTIEGIEPSDAGKFDITVENRLGTDTACAYLGVEDVPHPPVGQPWVSDVTLTTATLSWYGPAYDGGCSVTNYRVEMCDAEEGEWTLVTSNCVSTTCNIEKLRALTPYFFRVFAENKHGLSAPCQTPDVTVTSDKRPSVLMRLPSTESDDVFTHETNDPVTPMSEYGLVSPLSPVASLSDLELSDLLISSVALVSDEASFEHREVTIYPTNSFDTLYNTMEEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ET33</accession>
    <name>A0ABY7ET33_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CP17A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_027308</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF20">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR13128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="467" mass="53194" checksum="D9EE9F32A1583A39" modified="2025-10-08" version="1">MAMEAYLPSSPISTGLVALVAGLFSFWLFRRMRYNYPPRPGPMKMVVVNKIDEALEVLVKKSTDFANRLITPSVEMFTDGGRDIVFSNYSPTWKLHRKLSSKALRHYMQGPALEQRVHAALETALAEMDGHADSPFDPIEHINFIVGNILTGLCFGGSYVFEDKEVNFILEQEDLLLSDGLASGTLEDFLPPIRHVYKSQGFRRLEEFYKDIIEDFIGKKYYEEKKTFKRDELRHLVDHLILARMEAEESEGDGLVALTDTRIIQTLSDIFFAGVDTSRMTLRFALLHMAAYPDIQAKAYEEIDRVVGRGRLPGLSDRPDLAYTEAVLHESMRIATVLPSGVWHETLCDTSIGSYKIPKGTPVMINHWALHHDPDAWDEVEKFKPERYLDEHGKLGPKPKSWLPFGAGKRVCLGEFVAKPELHLIFASLLQRYRWSPEAGRVVDISPERSLLSNIPKSQKLLMERRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUI9</accession>
    <name>A0ABY7EUI9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="278" mass="31261" checksum="D0BDFE87DAE65712" modified="2025-10-08" version="1" fragment="single">MSRNRGYRGDESDKGLQENRRDPRVSQKHAQEVFYTEGSQESIPMQQMSPGGPPHMQDPGLSQGYITPSIESIIAKRVLTVAVLIFNETLNWLQYCDWIGTINLPPVFGHIGKKSKTDVVECSADAPFLPSIYGLFCGIATVYALLQIINTIGETVLEYHARKSGTKYEDTGSSQSQLPQNSAQPGPLPQDRSQNQPETNDEDPERQGEEEQKSIKQRCFSIFYGFQLLHGWVETVAAMVVEDLPQLIVMAVSSYYCTVNLENAFREKECIEQVTQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVJ8</accession>
    <name>A0ABY7EVJ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CTR2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF105">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="155" mass="16847" checksum="311AD8E2D16F0984" modified="2025-10-08" version="1">MIPGSNFYAIATSSSIIEGSSEGQYSTMGLLHKLTRRKFISADTVESTQLARCLNTVDLTALGSCNAEREHAGPSHELGLCLMCPEIMSVNAGPTVCAMLSLEHEFLESLCYAEFGARVPRTGSAYVYSYVTIGELMAFVIGWNLILEYVIAHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVU8</accession>
    <name>A0ABY7EVU8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G2E3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_027600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="3">
        <location>
            <begin position="42"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR13420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="377" mass="42810" checksum="91E6590C98892831" modified="2025-10-08" version="1">MDPQTDFESALNDRFDKMVLEGSWPINVVRRHFNNTAMEELSNGNIKDWGKKLNVKFIGEDGVDSGGLTREFFSLLFETSPVFEDNGFSYNADLLEKKHYQLMGKATSMAILHGHPGPRNLNRTIVDIILENKEPEEIPECCIQNAEVKAAIEEISTATKETIGDVFERHSHLLEASGYKQLLSVSNRDRAIHTMKFYYCFYKYIPPMLQFIEGLKLHDMLLLLTKHGENGRALLCCDTKSTSMSDVLAFFVPKFSKSEHEKADEEMIVYNFGKFLKKVENGAISTDWVKMNSSEESLKEVTINLGDVLQALIGCRSLPRNIKSGEMEFDHLSNQLSYVNTCAPSIIFTRTKELVNYEKLEHHLICIIVEAEGFGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXG0</accession>
    <name>A0ABY7EXG0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S22A7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_027294</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR13114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="380" mass="42594" checksum="4F5E04D51798D97C" modified="2025-10-08" version="1">MTQGPEVVGIEELIEETGGCGRFQVLLCAITHSCKCIICFSMLFMVYGAAAPDWWCSEGIELGNVTSGAAGNDSRRKGCEIHLNGVSKPCEQFKFSDEMNTIVSRFSLVCDHEWISSTITSIQMAGILVGNIACGQVADLIGRKKPFFASILALVLLNIGAAFSVSWVMFAVFRFLIGVSVGFEVIVQYNLTAEFTQTRWRTWVVAMPSWAIATSLFALVCWALNDWVWIHIATAATGLPLLFTYWFVPESFRWYIGHDRIEDAKQIVKKMARYNRKPVPKSLDYIGKENAESGDQKYFFSDLFKERKLRLYTCLFMLETMFEGSLYWISGTALVVAMALLVPIPETGRRDLVDKIVLPIAPPTVEDDDSEEKQETTSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXJ0</accession>
    <name>A0ABY7EXJ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50960">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="164" mass="19350" checksum="5218EDFFFBB58E51" modified="2025-10-08" version="1">MDENGVMYTYSMNENGVMYAYSLDENDVMYTYSMDENGVMYTYSMDLNGVLYTYSMDENGVMYPYSMDENGTMYTYRLKENNGVVYTYSIDIDKNVVMYTNDKDKNVVMYTDDKDKNVVMYTNDKDKNVVMYTNDKDENVVMYTNDKDKNVVMYTNDKDKNVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EYR3</accession>
    <name>A0ABY7EYR3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018:SF1">
        <property type="entry name" value="TESMIN_TSO1-LIKE CXC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="287" mass="32386" checksum="98C2BEC42B9A793B" modified="2025-10-08" version="1">MTQIVPAQAHNENYWPLSPMFDSDTTISYSSSTMQYKRQNSKINVYVTMEEQHTQVVPSVVPTVVSGLFDNSESDENTDYLTSDNYTIVKKTVSYLNPGQIPVMAADQPLFALAKQIQWTWPNDFDEEMFVVMFGGLHIELAALKTIGDLLQDSGWSSVLTQANIATPGTADSFLKATNISRTRHAHQVTSAALYVLMKQQYDEYVEATKDEIGPEMSLEMWVDVRQNESPISTMQYKRQNSKINVYVTMEDNKHAQIVPSVVPTVVSCLFDNYDGFIDYSTKPRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZ13</accession>
    <name>A0ABY7EZ13_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4CLL4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_004444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd04433">
        <property type="entry name" value="AFD_class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42814">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42814:SF3">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="91"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="478"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR14339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="575" mass="64731" checksum="D9184461AB391A0F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZN2</accession>
    <name>A0ABY7EZN2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NINAB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_004427</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR14322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="240" mass="27075" checksum="9D9122605BB338F9" modified="2025-10-08" version="1">MYKLYQTVNTEYISPVKGTIKGSIPSWVRGSLFRNGPGMYEVGEHKYNHLFDPLAMLQRFHIVTYQCRYLQSDAYKANIAANRIVVAGLGTSAVPDPCKNVFQRFMSYFVDSAPLSDNNLISFFPCGDNLYANGESACVHRIDPNTLDVIKRVELIDYMPMNTMAAHPHIGPDGTLYSIGVSFQKSGVKTCITKTPPIQENFYVYVEQPVLIDLIKVLSSTLRQQPLDKVIRWSPDIKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZQ0</accession>
    <name>A0ABY7EZQ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SACS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46919:SF2">
        <property type="entry name" value="SACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46919">
        <property type="entry name" value="ZINC FINGER, C3HC4 TYPE (RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81593">
        <property type="entry name" value="Nucleotidyltransferase substrate binding subunit/domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="245"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="374" mass="43695" checksum="45906E6422A8AA03" modified="2025-10-08" version="1">MDETFERSDPALCDDEIDDYSPTYIFVRVIQRIERTAQEHELVQEYEINIGEEKTVTVKAYLLYKFVRQKKVQLSKERSIVLYERESSEASFVQERSLKDICVEIRQILIDAWPRNDIERRHIVKRLMLKWHPDKNPDKVKLATKVFQYIQHCLGLLESGKPIPEYAGDDEDFVKRSQSSGGSSYWHDRFWQRYRGSYDDDDWYPRGRRNRRKKGSGAHGGQYNYDPFSGFFSEDRKPYHFYSEAKRWLAQADADLLEAERSLRDSEMANNWICYKAHQAAEKSLMAAWYAKDANKIGSVKDSHELTSIAYGLDSTLKALARQITVISGDHRRMRYPHTLSGTIPAHAYTRQNADIMTSLAKDVNAHVRGNFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2A0</accession>
    <name>A0ABY7F2A0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PUS3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="63" mass="7160" checksum="76EBB85A18D7D027" modified="2025-10-08" version="1">MYLGHDYTGYAGTEEAEHTIERELFEALIKCKLIESKESACYSRCGRTDKGVSAFGQVTRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3R5</accession>
    <name>A0ABY7F3R5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="118" mass="13929" checksum="A83A5A752C34E158" modified="2025-10-08" version="1">MSFEYIPHATSFQGHNFEGDTEEYSFESGQILENRHFYPDVKCCKYGSSSQLVELSVPLTVWVIYPTEKRLMRKNHLLYCENSTKLNHVQTKNLLQHLEIQGHWCFVGDTPKNWFVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F467</accession>
    <name>A0ABY7F467_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3504 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042838">
        <property type="entry name" value="KIAA1958"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46963">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA E130308A19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46963:SF1">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA E130308A19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="34007" checksum="86130739EB025A53" modified="2025-10-08" version="1">MYVLFSAIRKHDGTEYEPDELFSHFNQILISKRKHLKAMDKGNLKSKAESLTKEEFQRLRDSFLAKREVNKLEKDPAENLTEKCTQAYTRRRPTDILDDNSRFYLQTVNTPKTDLWYSHQPLGKNKLGQIMKQLTEKGSLEGRKAGRPPTEIANLGGWKSLQTINAYSTPTLAKQAQASDIISDLIMPSSSTADVPHSGNKVQSIEHDQTSVLADVTPVMNTSNHTCNTLDASRSMSSKISKQNSNLFAVLCGANIYGGTFNISIVSEKMKLFYDKYLKFHINDFIHSRRLDAIKIVDAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F546</accession>
    <name>A0ABY7F546_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="121" mass="13827" checksum="E61781C24845D544" modified="2025-10-08" version="1" fragment="single">ICSESKLNASVCNIFYAHKISCFADPCCSTLVKNVKEGILRSVGKKHITIEPIRNKRQCSYIWFKEDCIEVLLRQSKTDQYKKGDVVVIAKSNNDVCPVKILRMYMDLAELSENSNDFCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7D2</accession>
    <name>A0ABY7F7D2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_031278</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF108">
        <property type="entry name" value="CLAUDIN FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR16684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="126" mass="13954" checksum="1C03832A7F4A11D1" modified="2025-10-08" version="1">MSKSLPVLALFLTLMGGVFIVIGLATPNWITRNSGQFHQGLWKYCANNNPCLKLERGPVCFTMSGIFLYAAKKNQGFFGGRHDPNEYDFGWSFILTAVGGVLMFGNAVILVIQLRKNTELGTYESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7V1</accession>
    <name>A0ABY7F7V1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TENX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_031443</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="4">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR16849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="459" mass="50748" checksum="15808A22B0065804" modified="2025-10-08" version="1">MCDQCVAGYFGNDCTHICPAGCSDTCSKTNGSCTCKFGWIGDKCDTCAYKYFGKNCNETCNSNCEDCTGKYECQLCLPGRYGYYCQFSCGKGCRNDRCSITSGYCECKSNYFVATSSSGYCHDCVLGRYGLTCEKICPQSCLACEQELKCSSCHVGYFGLSCDKSCPYECEENNCKQEDGSCVSCKLGYYGEHCKNTCQESCRSCDKYGLCSECKPTFFPNNTGQCETCNSKCVANNCDSSSGRCIQGCYDGYWNRTCNTECDAACFSCKQTNGSCSKCKNNTRYGPDCRQECSNTCKSSVCDVNGSCINGCIVNTFGKQCEQRCGEYCLRKDNQTICSEKTGMCLYGCRTGYTGKDCPQDEKPITLSAALGWGLGGGILGLLVIAMLVMWLFREGQTRNTIIYFMMAIEIDYDTVDTNICEIELNDLQYETLQERDFQGMNLTTDFSNVSERENGNMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8G0</accession>
    <name>A0ABY7F8G0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inhibitor of growth protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_032506</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15585">
        <property type="entry name" value="PHD_ING3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042020">
        <property type="entry name" value="ING3_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="8">
        <location>
            <begin position="119"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="552"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR17912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="612" mass="68764" checksum="7061161710F475F7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8R3</accession>
    <name>A0ABY7F8R3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR17559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="174" mass="20449" checksum="DFA9C7E1FEF4B9F6" modified="2025-10-08" version="1">MVVKSFVIARVSFVNISGILLFCKICQILKQTECFIDNRLLSSLGYWLYRKTISGLYMRKWQYDVMRIFILKIVADHASPDRKIKFDDFMDKVERGNIGGYTKYEADVFIEAWYGACFKYPNHFCQHETKEMKWQHLFYFCTRRENGVLPIAARISHGNGVLPMAARISHDEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAB8</accession>
    <name>A0ABY7FAB8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="33"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR17633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="845" mass="95964" checksum="B4C4642CC2B52EBE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FC04</accession>
    <name>A0ABY7FC04_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TENX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="233" mass="24994" checksum="E3D85D7C3098A372" modified="2025-10-08" version="1">MEFTTCSANCLDSRCEKSYGFCTDGCLDGFTGATCSDKCDVICKTCSQTNYSHCTSCFGGLSGPSCKCIPNCQCELNSQCLQGCNERYWGQNYNHSCHPSCTSCLQENGTCTQCVNNSLISFGDYCAIQCSETCVNKLCDDTTGRCLQGCVRNFYADKCDLVCPSTCASEPNKTRCDNYGRCLHGCTEGYKGITCASATSTPKSDASVGRLIGGTVGEAITIVSVIKKRTINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCR7</accession>
    <name>A0ABY7FCR7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF5">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="55793" checksum="B39FE8A87C65FE71" modified="2025-10-08" version="1">MDWNMSGARKYEMLSPECISANREPVMYPPATCPVTECSKNDYSDNCRQSFRYLETKNNNSTLSLSLMVKLSLIKWRGVYVKAGMEMSLCKGLLLHILLEERQCHVPCQEEQEVGCFHQLTSGRDPERAILALQGQVELARGLEKEDWLANTARKLQTLQFHDDNCLRDNVGPCQNPNLEHVMADEGRLAQSNPDSTEVGSVSSGDEALLLASPVKDLGKNVDEVPVDKASLSALGSVSLGATGGLRLELREEARTVKSLGTWVSACCSVVPMSTGSVQCERGFSTQNRIVTQLRTSLNKKNLDTLMRIRKDGPPLNQFDFNRALLKWKRCIEHLRKLLKCPEVAGLGEVGLYRTEPTGRLRPLLQIRVTMGAGNSQFRPTPVFNSDGTYRVYQPPATLNRKLAEFPYNFHYTNSPFVRRVVFCATFITMPVMFAVYFSLQTKQNKIMGKKRAAAAFESPHERPRVYNPPQVEPYQLGSGFDRLVPWKMADFRVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEF1</accession>
    <name>A0ABY7FEF1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_000984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="301" mass="34951" checksum="2D489FE036E976BB" modified="2025-10-08" version="1">MASWVEENELLFNKRLNAYKDFKTKDALWESKAATMEKDADILKSWYRSIRTRFTHLVHRKSWDGAADLTGRDRWILTNFTWLRAKKKATASRKAVADSIDDGNDDQSEDPTDTETMTNTHQRLEPFPRRSATSFTKKEEERLLSNIAAREEQFIAFQNKELTMLALSNSTERTRYADLAKEVMVNIYPSLWINFQRDCSSLLYTYLENNEKLPDPATQQQQYSAQQPKYSTQLKQQYQLYPMAAPGTSPTSVMWQQPPQQWHTTAQENMSRWRSQHFALVQGQITGLQPIKPVVHGSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FG30</accession>
    <name>A0ABY7FG30_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="187" mass="20645" checksum="C1A810AC017AA8D1" modified="2025-10-08" version="1">MPNSFGAELSGNLLGNFNRTVLWKSITSGIPLGQRNQVIGKSGHSLKDRNYVEFQVTQAEINIILLNETSKFTFGFVRESASAPTSSSSDSIMNTTFAGPSPKSSTGYRGKEPVKKHCAVQQKRYQLPFKGIKHQLVQECIVCSLEAFYILRWHRNVALQSQFLGTGEGSLMQPAVCIYGYSTSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FH27</accession>
    <name>A0ABY7FH27_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DPOA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_002175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.530">
        <property type="entry name" value="DNA polymerase alpha-primase, subunit B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043034">
        <property type="entry name" value="DNA_pol_alpha_B_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013627">
        <property type="entry name" value="Pol_alpha_B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08418">
        <property type="entry name" value="Pol_alpha_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="5">
        <location>
            <begin position="169"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR20337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="430" mass="47098" checksum="4CFFC22F8C36A98B" modified="2025-10-08" version="1">MTSLVAEEDLSEEFSMFGIELDDEDVVLKLQELCTMHRLDAGNMRLSKRHQKTPKSVKKGNAPKIHSIDTLPMDVEAAEELYSAYGGNTPTSKRTISNKRQHTPENAPIKRFTGPNRSPAVPYSPSSFSPASTTPAKKYNSRTNRGDVVASLSDTDGTAWHGSGKEVTIETYAPEQNKVHNIEEFSHVALPTQEEVTIVGRICCDSNGKLNAKSVVLEGSIDMSSGKMIPVDLSQLKEFALFPGQMVAMTGHNSTGQKFVASKLLESVPLPLPEIKTSQENASRLSLLVAAGPFSTSDSLSYEPLSDLVEQIRIVRPDVCILNGNCTLPFEEIFQSKIEEIAQATENEEMCIDYEKFPASGFMPTTPHIFILPSEFKQFIKDIKGCCCINPGRLTKGLTGSTFAKVVVETNKLASNQPLVKNVTAQIVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHS2</accession>
    <name>A0ABY7FHS2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="56"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="202" mass="23330" checksum="FAEF1EC2CF3DD90D" modified="2025-10-08" version="1" fragment="single">MVLCSTKRVGNIEVVDIEYNEDDSLAIHWGLFLQKSPLRIFGKSVQVVLHESMKQPKILVTRLPENVDYEDVEMFFENRRRFGDTKPLDIEFNEGDHSAILTYDTEFSASFVVNRSPMKMQGSELLLRKLPIDEIMGSDVVIADNGIGKEQTQLLIEDIPEDVDKEFVEMFFESRRFNSCEVIDVDFDEKDRNAVVQFAKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJZ7</accession>
    <name>A0ABY7FJZ7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="225" mass="25460" checksum="5BEC79994D2B0480" modified="2025-10-08" version="1" fragment="single">MLKTTRTHLRAKMVHTDLAIAVLLLGIVYRTQAVFNEIAKTKVEITTTLRPCSNKRTKTGVLDVYEEWVKGKGWILRRCPHGFLYEPKDCDCTSRVVLQKNCEPDLFLSFENGVNDQSPIVNYIQSKNVKVIDGKAIFKAEMGSQLIIPRYKNFCISSLTINVKYFSEHKRLTQTQAIISNSDCGIAPSIVLSEDSAYIYFTVATDMGERILAVHQPSHTNDKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQA6</accession>
    <name>A0ABY7FQA6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ACES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_037461</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="36"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR23792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="593" mass="67730" checksum="D945548175673DFE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQN9</accession>
    <name>A0ABY7FQN9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FUT8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_038014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045573">
        <property type="entry name" value="Fut8_N_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027350">
        <property type="entry name" value="GT23_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19745">
        <property type="entry name" value="FUT8_N_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51659">
        <property type="entry name" value="GT23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="GT23" evidence="8">
        <location>
            <begin position="154"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="319"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for donor substrate binding" evidence="5">
        <location>
            <begin position="177"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR24345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="388" mass="45257" checksum="E06A81BF174FD652" modified="2025-10-08" version="1">MFEMNVKDTFRYFLLVWIIFIGIWFLYMNRGTDRIAVFKHHTAFKIDGLNTPSANANTYTDSVRLKEVILNFTDFAESCLRHIVNATNSDTVDKTLDEINHFRRNTDSDFAKHESLEDVSLRAVETSIVDPLEIPAPFVNQIGIFHSYPPAFWIGLLSNMLFEEDIFEKQLLNVHIRRTDKIQQHEARFHTLSEYIFHVANWYDAYEAVHGFTQRTVFLASDSPDVFEEAVKEYPNYTFIFNNQTLPTADSEDHKSMEELPLHGIVFDIQLLSRCEFIVCTMSSNVCRLAYELMQLHHGDASEKVVSLDIDYYFFKHLPRMYTAIIAHSFPFKGEITFEEGDVILVKSGDWRTKQTPGFLFGKNRRTGDEGLVPRFKIVEIFKRRIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUI1</accession>
    <name>A0ABY7FUI1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GA45A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_038386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GADD45 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024824">
        <property type="entry name" value="GADD45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10411:SF8">
        <property type="entry name" value="FI09246P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10411">
        <property type="entry name" value="GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="2">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR24717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="158" mass="17875" checksum="D50755ADAA05E576" modified="2025-10-08" version="1">MTLPDHEEISMPEKKIEKSAGQCLCKVLVRARDDGRLVCGVFDSASRLTTRPEEVMVCVLPETAPADITTSMQHKLIEAYCLENDIQVIKIKNSEKMGILLNKDAQLKSEMDNPVTTPTLDTSCVLVEWPPKPHINKHEHRLLDFIWSKQVTQLDLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVK6</accession>
    <name>A0ABY7FVK6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P85AA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_038440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd20830">
        <property type="entry name" value="C1_PIK3R-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12923">
        <property type="entry name" value="iSH2_PI3K_IA_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09942">
        <property type="entry name" value="SH2_nSH2_p85_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032498">
        <property type="entry name" value="PI3K_P85_iSH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035022">
        <property type="entry name" value="PI3kinase_P85_nSH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051854">
        <property type="entry name" value="Rho-type_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075">
        <property type="entry name" value="CHIMERIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16454">
        <property type="entry name" value="PI3K_P85_iSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00678">
        <property type="entry name" value="PI3KINASEP85"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="7">
        <location>
            <begin position="86"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="157"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="383"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="661"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="487"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR24771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="775" mass="88434" checksum="4A8EF3844E2E955A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FW46</accession>
    <name>A0ABY7FW46_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883:SF12">
        <property type="entry name" value="SEA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883">
        <property type="entry name" value="YIPPEE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="584" mass="61138" checksum="B4A5F3072A68AAA8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G121</accession>
    <name>A0ABY7G121_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HDHD5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF4">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="411" mass="45903" checksum="CE4F44417CF41B5D" modified="2025-10-08" version="1" fragment="single">MRDIANMRDIAICQDDGYNTDGSDCSDLTKDLKQAILEDEPDFGVLFDVDGVLARGSTPLKAAVEAIELLKDNEGRLRVPVAFVTNACNRSHDKAAQIQKWLNIQVALDQVIHAPTPARLLTEFHNKHVLVIGQEHRVEIANDLGFTQVCTMEDVARAYPLLDMVDHDNRERVASGHHPDDSTFPAVEVVLLIGEPMRWETQLQLLIDLLLTEGKPVSSHTPKSVFQVKQLPIIACNMDLVFMHQACMPRFGHGAFLVCLEALFKKITGTDLQYHALIGKPCEITYRYAEHVIGDVAKRLGIQRPIRKLYFVGDNPNVDIVGANLYNRYLQRTISNQENGNTQDETSHNLPTCRSIPRSISMCAQTVRSIESVLVGTGVFDPNKKTGNDDADDVYHGHRDIMHEPELAKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1F3</accession>
    <name>A0ABY7G1F3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="207" mass="23343" checksum="918F576B8BB7EB10" modified="2025-10-08" version="1">MYAMCDSERLHVDKKINKVKLGLSGEGGIGQSNTYRIGIKVPKEERGTVFDFEAKLDNKARAAFDCSYSDVNELSSRGKSTHVSNQFKYPIWVKCDSERIKVNKGVRGISGNFKVGSNVSANAKFKEEVGIKADKDARVGGSINYTDKLSRRFIEIGFTRFTPDKHTRFDVDCKGTDTVYIWIYYNGCAMEFRRNKITVSSLVQMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2K5</accession>
    <name>A0ABY7G2K5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing family member C2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_014359</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040193">
        <property type="entry name" value="EFHC1/EFHC2/EFHB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086">
        <property type="entry name" value="EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086:SF11">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING FAMILY MEMBER C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06565">
        <property type="entry name" value="DM10_dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM10" evidence="8">
        <location>
            <begin position="101"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="8">
        <location>
            <begin position="252"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="8">
        <location>
            <begin position="433"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR28655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="693" mass="79719" checksum="548027C17C860192" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2Y4</accession>
    <name>A0ABY7G2Y4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="198" mass="22450" checksum="2F4A853C237491B6" modified="2025-10-08" version="1" fragment="single">TGEPPIFLGPSFLHGKSDFTTFDAFFSHTASHLSDSELKRLVVGSDDEQALRKSIQSGQAAGFLPYLNGRIAPLIKNHVHIPKRVRNIDSNWTNNNAESMNNLLKIGTNHKIEDMTDLIDIIYRIVQSMYIDVEKSIVSMGNYKLTQPYEHHKMSVDVWCQKTEQGRKGILAKFYSDKGILYCSVLFCSIYYSALADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G451</accession>
    <name>A0ABY7G451_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="76" mass="8407" checksum="BB0CB8B205E02281" modified="2025-10-08" version="1">MAGCHFNHWGRKTTDKRLRGQGRAIGRGEYSKRRSIDQIVQCEVTDRLLDGLASSASTTLSLSTCFSNASSRETMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5N1</accession>
    <name>A0ABY7G5N1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF1">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="442" mass="49843" checksum="31D84869CDE85B19" modified="2025-10-08" version="1" fragment="single">IATHVVRLLDEFREESRKVSPTFQVWNNYLSRVSTPLKLLLASTRSPSWTVYQHAKLQLMPLLFASNHTIYATFMSIQILTMNRLPTEVEEGFLACLFTKTVTRKYRGDCSSCRIVDVRGELKVSKDWKMFLSNGQNKERLIQFYSGYMAEHACTKLKPQEVLLINGGKSTPCVIVTTNGCCNQPILDTNQEEADTVMILHAKYEADRGSTCIAIHSPDTDALVLLLHHYRYIGAAHLCMSTGRVTLHTDGRRFIPVHQLINKLTKDQLNILLSVYCITGCDTTSGFFGKGKRRNNCFPTFKEQHALGLLSVCTGETTCKLFIHQLRCIKAKSSVHPRNIPPTADSLNLHLQRCVIQLWIWRHATTAQHDLPPFTYFGYEIDGDGLTPKMMSQPAAAPELLNDLVCECEICSETCVCFANRQPCTVACSCTRNTNTDEMMCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6U5</accession>
    <name>A0ABY7G6U5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR30130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="384" mass="43097" checksum="BFA4C7F68B22C0BE" modified="2025-10-08" version="1" fragment="single">MAIVTLPNGLDVRPRHTLNNETHQDELCGGGETNSNLEEIGTDLDETKVHNETIDAEKDTEIIENASVSQDEEVLLTDKQSGDIAMRAEKVGKEIATSSMGIDLRKEDRGVSSTDSESGDVAMREEKSGHDIAASNQRTHLSGKTEGNTNKDEEVIEISSDIDIATSYQKTDLSGRKKDLTCSVCNLGFAKKEDFKLHLAHPSHALRLTTPLRKSSSFREPPKGPAEYKLCPRFEKHQRCSVCCTDAHGKDELDEWNAIRREHIDNINVVGVNLETPEMEKVAANFPPFDLPVTVESVQYATINQTSDLSISLPKKPLTHKWVFEIQSSIFLRRVTLANDSAIDVFLIHRVFDKTEDTIVYPTSLDWENKNKSRKRDSFQYEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7Y8</accession>
    <name>A0ABY7G7Y8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CC180-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_033080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027914">
        <property type="entry name" value="DUF4456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444:SF14">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14644">
        <property type="entry name" value="DUF4456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4456" evidence="3">
        <location>
            <begin position="457"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="686"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR30538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="729" mass="82196" checksum="30F6BD9F814AC958" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBM5</accession>
    <name>A0ABY7GBM5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034329</name>
        <name evidence="2" type="ORF">MAR_034330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="94" mass="9029" checksum="AB80C492E5E82897" modified="2025-10-08" version="1">MLFGPPGAFVTNGDAGALLIGGAAGTSVTGGATDALITGGVARASVTGGTAWTLVIDGGALLATLLSPLSGVGRDVEPGRGFHCAQNMAYLEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GCW7</accession>
    <name>A0ABY7GCW7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_033721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="425" mass="49863" checksum="58FF9541CAA1F418" modified="2025-10-08" version="1" fragment="single">MLFCLSGQIDSQNRLRQIDLQNRHMLFCLPRQIDSQNRLRQIDLQNRKHVILSTKTNRLTKQTETNRLTKQTHVILSTRTNRLTKQTETNRLTKPTHTYKTDTCYSVYQDKLDSQNRLRQIDLTKQTHVILSTETTRLTKQTETNRLTKQTHVILSTKTNRLTKQTETNRLTKWTHVILSTRTNRLTKQTETNRLTKPTHVILSTRTNRLTKQTETNRLTKQTHVILSTETNRLTKQTETNRLTKPIHVILSTETTRLTKQTETNRLTKPIHVILSTETNRLTKQTETNRLTKPTHVILSTRTNRLTKQTETNRLTKQTHVILSTETNRLTKQTETNRLTKPIHVILSTETTRLTKQTETNRLTKPIHVILSTETNRLTKQTETNRLTKPTHVILSTRTNRLTKQTETNRLTKQTETNRLTKPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GD49</accession>
    <name>A0ABY7GD49_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C3/C5 convertase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_033720</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell surface</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393:SF7">
        <property type="entry name" value="COMPLEMENT C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045347236" description="C3/C5 convertase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="14">
        <location>
            <begin position="183"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="12">
        <location>
            <begin position="299"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="13">
        <location>
            <begin position="471"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR31178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="770" mass="86972" checksum="C80CF56C92950885" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GG99</accession>
    <name>A0ABY7GG99_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="151" mass="16821" checksum="0130032AD267CCD2" modified="2025-10-08" version="1">MLSAHGTSILMAGHNIMLQKQSSNGLKAENSVLPWKQSLMEAKHGNFTFHRLLTLVKEGVEHGLIMFLASGSRYRIAFAHHVCLKNRDYANHTCPLLQEGVGHGILIMTSPRARYLLIFTNHSPEFFMAAATFSALANVSMAPEKKTMQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GIM6</accession>
    <name>A0ABY7GIM6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine synthetase</fullName>
            <ecNumber evidence="2">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_033588</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="9">
        <location>
            <begin position="127"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="GS beta-grasp" evidence="8">
        <location>
            <begin position="138"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR31046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="363" mass="41562" checksum="EF6BFE51526D66AB" modified="2025-10-08" version="1">MVLRHGEILVEERGKIVVRMVLRHFEILVEERGKIVVRMVLRHFEILVEERGKIVVRMVLRHFEILVEKRGKIVVRMVLRHFEILVEERGKIVVGKLTSNHKLLPTMSTAAALRGFSASTDKNVMKPYMCLDQPEDRVMCEYIWIDGTGEGIRSKCRTLDYDPKKPEDCPIWNYDGSSTYQAEGSNSDMYLHPCAIFKDPFRKGNNKLVLCEWEFQVGPCEGIDMGDHLWIGRYLLHRVAEDFGVNATLDPKPMEGDWNGAGAHFTPKHIESAIEKLSKKHVRHIRAYDPKEGKDNERRLTGLHETSSIHDFSAGVANRGASIRIPRQVAEDGQGYLEDRRPSSNCDPYTVTEVLVETTIIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBL8</accession>
    <name>A0ABY7DBL8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">CALRL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_006769</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15041">
        <property type="entry name" value="7tmB1_hormone_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF42">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR SEB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="13">
        <location>
            <begin position="99"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="208"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAQ94298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="545" mass="62125" checksum="6A94CAD8D3509FE2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDF2</accession>
    <name>A0ABY7DDF2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SANT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="546" mass="62374" checksum="A1D80A6C281A6A8B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHT6</accession>
    <name>A0ABY7DHT6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="116" mass="13234" checksum="C3093BEC3707CF0A" modified="2025-10-08" version="1">MSIRSLVHLLDMQCVDLGRCCALVKVYAQNYVSDVIPLNHSADTTKARKRKASILDYFETVNDVALGDSGFKASPKNTVDMKTPSRQPEEEQCNITMQRDLPIDIQPRDLHWDRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJ48</accession>
    <name>A0ABY7DJ48_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WDFY3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_029412</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15719">
        <property type="entry name" value="FYVE_WDFY3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BEACH" evidence="10">
        <location>
            <begin position="2599"/>
            <end position="2892"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="3028"/>
            <end position="3062"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="3070"/>
            <end position="3111"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="3418"/>
            <end position="3478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="845"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2163"/>
            <end position="2184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2438"/>
            <end position="2486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3124"/>
            <end position="3163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3212"/>
            <end position="3250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3273"/>
            <end position="3308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="854"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2168"/>
            <end position="2181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2469"/>
            <end position="2482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="3283"/>
            <end position="3299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAQ96722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="3489" mass="390857" checksum="9287C4EEAD9DCAA6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJ90</accession>
    <name>A0ABY7DJ90_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BBSome complex member BBS5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_007546</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriolar satellite</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BBS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006606">
        <property type="entry name" value="BBL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030804">
        <property type="entry name" value="BBS5/fem-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014003">
        <property type="entry name" value="BBS5_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21351:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21351">
        <property type="entry name" value="BARDET-BIEDL SYNDROME PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07289">
        <property type="entry name" value="BBL5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010072">
        <property type="entry name" value="DUF1448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00683">
        <property type="entry name" value="DM16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBSome complex member BBS5 PH" evidence="11">
        <location>
            <begin position="28"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="BBSome complex member BBS5 PH" evidence="11">
        <location>
            <begin position="112"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAQ95075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="272" mass="31037" checksum="031981259ED2569D" modified="2025-10-08" version="1" fragment="single">MSTSEGLWEDRDVRFDISGNQMKMRAGEKLIDKMDAVEDTKGNNGERGRLIVTNLRLIWHSIGMPRPLDLTVSSIFLQKQLSQAYETSKLYRDLKLRGPLIQNKNLRLLPQEQVYDKVTGVWNLSSDQGNLGTFFITNVRLVWHANINESFNVSIPYLQMKTIKIRDSKFGLALVVESSSTSGGYVLGFRIDPVEKLQQTHKEIQSLYKVYSACPVFGVEFEEDDRPQGLDELTIERVQDDNKDRDPVYSEELGLAVEKLKDGFTLSGLWDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJH9</accession>
    <name>A0ABY7DJH9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="828" mass="94723" checksum="EAF3AB418BBE69C1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQI6</accession>
    <name>A0ABY7DQI6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPTE2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_023531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF60">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046211597" evidence="2">
        <location>
            <begin position="19"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase tensin-type" evidence="4">
        <location>
            <begin position="61"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="94"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ99158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="230" mass="26427" checksum="6DCE707CCDAD4F68" modified="2025-10-08" version="1">MVIVIVTFVLDIVFSGSGYPRLGVVGRGLRILRIVRGIYLIYQQRKHLAVASRRIISQNKRRYVKDGFDLDLCYITERMIAMSFPSSGVQSMYRNNIREVSRFFETKHKGHYKLYNLCNPENVVAIHCKGGKGRTGTMICTWLVECGNFEEAQDSLDYFGDRRTDLDHGSTFQGVETPSQSRYVGYFGVVKNKLNGSLPKAKYLKTNIPAVYDNCAFYFWFHTAFVDDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQY8</accession>
    <name>A0ABY7DQY8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LACH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_023379</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="51"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="152"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="249"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ99006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="435" mass="49523" checksum="FD061A1133D93501" modified="2025-10-08" version="1">MLKFSSRPCGNDLRISLNRLYQGYRRNCDAHFRATVSIVGGESMDRAPIQPIFDTSTENVTAIAGETAELRCTVENKGSYNLIWLNPRKTLISKDDSRFIDDSRISVERPNIRYWNIMVREVRYNDSGEYMCQINTKPVLIKRIILNIKVAPEIIEDWKPTKFEVQEGKMVELVCNATGVPMPVVTWYREANLIRDYSEQPEGERTLQGETLRLHNITRFCDGTYECNAENGVPPIATKIFKITVQFPPEVRLTVRRLGQAIGRETLLECKVAASPHATIQWTHNGTTLPLHLFKYVTNLYNDGVHEKTLTLNIIDIQQEDFGQYTCHASNGLGQDSETMLLYEYNIVTGPRRPQVTTTPWRPSGRPPPRIRPPSTNQGIITPSYYEKKQGGRNQQPSYGGSVYYNYNTANGTVKLTTVSILNIAVLLYHVMRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRY6</accession>
    <name>A0ABY7DRY6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CASPB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_024246</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454">
        <property type="entry name" value="CASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454:SF210">
        <property type="entry name" value="CASPASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="3">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ99873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="356" mass="39962" checksum="19F24F42A48E9E0B" modified="2025-10-08" version="1">MAQRGQAVIIVNKNFPNHKSPRKGATKDIKKMFKLFTLLDFRVKPYWNLKGEEMRKVITKACEHKSNKDSECFVLVISSHGREDVNAKTGSGDVVHEHVVLGTDDGVVLVEHILKEMENPTLKGTQKLCFFQACRVSTHRLSIMKDGVDSGVNVKAVSTVGGGSGGSDGGKGNSEGMDVEDIVDSLLQDLEKPKEEDTAENECTVIEVIDPLSLPDTDDESEEDEEVDTQPLQDSGHPPLPPPRNVVPNYCPRDCLVMYPVQPRSWMLYFLYKNKEMLLNENENLSLLQYLTKVAADLAARDYNWGSVKELQMAATIVHRLTADVRFQPFEHGMMSRFIQKTKTKAGFFRKHQIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DT51</accession>
    <name>A0ABY7DT51_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LAM0-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_025285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF11">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="9">
        <location>
            <begin position="48"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="8">
        <location>
            <begin position="409"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="102"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR00913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="551" mass="63434" checksum="D6BD279581514318" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DW03</accession>
    <name>A0ABY7DW03_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_024631</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="10">
        <location>
            <begin position="10"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="83"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR00259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="122" mass="13841" checksum="496A75D28DFC50FB" modified="2025-10-08" version="1">MDQMAMTEEQNARNMKDFLELYNRLTERCFNQCVVNFNSRSLSEYENSCVEQCAGRYVKYNQRLMTTFVDIQSTKQEAIIKEMERATAEGRQPNLPGANPLSATGMTQSAPESAQPAIQTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWR9</accession>
    <name>A0ABY7DWR9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HISAT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056483">
        <property type="entry name" value="Hisat_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47403">
        <property type="entry name" value="LOC100145250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47403:SF6">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24066">
        <property type="entry name" value="Hisat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="321" mass="36634" checksum="7BE7BA7706C1D3C2" modified="2025-10-08" version="1">MTSTEDNVLYREATADDKTAVIDIRRNVYDGIDYLEAYYDAFMAAETITCYVAIFQKQVVGFCAAMLLDGGKTFSPRAARVSPMVEGTGVYFALKNYAARQSGAKREALTASDINPNIRKESFKNAYKFVLTRKFIRYKIDADVLKSLQIPKLTGPVRQIDRQAFTEYMTTPVTSGYLFPAGRVIIDWVPFRLLPENFPVLESFEGNKCRIFSSMTPITPTNGLVTINTMYKTSQLKYHCNIDIYGTKVDSLKDHMLQNLTQIKEADCDTTSLIVYTPMDFDTEYLDKLFIEFGLPRNDWIFESLPSENVLELYLYEKSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWX6</accession>
    <name>A0ABY7DWX6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CADN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_007880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056370">
        <property type="entry name" value="Shg-like_Ig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF432">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24811">
        <property type="entry name" value="Ig_Shg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="90"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="199"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="306"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR01322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="648" mass="72155" checksum="C9B0FA89596B2799" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXW3</accession>
    <name>A0ABY7DXW3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent protein deacylase</fullName>
            <ecNumber evidence="3">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Regulatory protein SIR2 homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_008079</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N(6)-glutaryl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-glutaryl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11875"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87828"/>
            <dbReference type="ChEBI" id="CHEBI:87829"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N(6)-malonyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-malonyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11878"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87831"/>
            <dbReference type="ChEBI" id="CHEBI:87833"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N(6)-succinyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-succinyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11877"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87830"/>
            <dbReference type="ChEBI" id="CHEBI:87832"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-94 and Arg-97) that bind to malonylated and succinylated substrates and define the specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01121">
        <property type="entry name" value="Sirtuin_ClassIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="25"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="113"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="222"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="248"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR01521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="341" mass="37591" checksum="7275E4D2758562E6" modified="2025-10-08" version="1">MSLLLTRKFAQYSLNLTVKMATETPKQPSSDMAAFRKVFDKARHIVVLTGAGVSAESGVPTFRGAGGLWRKWRAQDLATPWAFQDNPSLVWEFYHYRRERLAKQGRRVVVVTQNIDELHKRAGSENIMELHGNLFTTRCTKCGHIEKNHDSPICEALRGKGEPDPTAEDARISPELLPRCKQEGCGAMTRPHVVWFGENLNEALLDSAQKELDLCDLCLVVGTSSVVYPAAMFAPQVANRGVPVAEFNIEPTSVTNSFGFHFTGPCGSTLPEALAPTEIIRLVIVFIFINTVLQSVDNLSVALILKAPKSTNAFLLNISVEQNFALGLLKPFTAGILNNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DY21</accession>
    <name>A0ABY7DY21_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LNX2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_008070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd06679">
        <property type="entry name" value="PDZ3_LNX1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF84">
        <property type="entry name" value="LIGAND OF NUMB PROTEIN X 2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRAF-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="64"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="204"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="320"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR01512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="396" mass="42097" checksum="703924EEA8937D7F" modified="2025-10-08" version="1">MLDKLLVVCPNTDHCEEVLPRVDLEAHLAHRCRGTVTRCIRAGLGCTFRGPRSKNAVIKGEVTTIEIERDQIDLGISIVGGCDTPLVCVVVQEVFPDGAVSRDGRLQPGDQILEVPNGFAVLEGGLRVDDRVLEINGVDVAFSSQEHAAAIIQASPDRVQFVVSRTSRPRTPDLGWCRPATLGGLDAEMAAAVWPICRKSREILITIHKVLHESLGISIAGGAASPRGDTPIYVTNINPNGCLAKSEQVQRGDVLLAVNGANLLGLSHPEAVARIKANTRSNVVTLRIVEAPEACNGSGNFVPSWLFWQQLPNACKTVRTVTLLRGSAGGSLGFSVVGGADCPQGPLPVYVKCGDQIQSVNDVSLEHVAHSKAVHILKQATGAVSLRVVSWPGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DY32</accession>
    <name>A0ABY7DY32_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MNN9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF6">
        <property type="entry name" value="MANNAN POLYMERASE COMPLEXES SUBUNIT MNN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="291" mass="33601" checksum="06C1E34CEC3F2C6B" modified="2025-10-08" version="1">MQYNYRNKLALGSRKSPLNHVPPLPEKTRTDVVPYFRPEILDHFRSLPNKTYEDRIAIFTLIRNVDRVLRNYLDNLVKLDYPRRLISVYFGEDGSSDDTFATAAKLSKELTDIFEFNTASVFHFDTSHNVSLKETQLISRHTFQKQLRRRSQMAKSRNLLMKMALNISNPDYIVWIDADLECFPSDLIEQLLYARSDVTAPPCLGVYNGVKKCTTETAGEKHPRLLNLNLCYRNKSLLLRATQNQIEYTSLISKRWAGWFHWTGSAVASLWCGLSITGMDLCFLKTCFNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYJ1</accession>
    <name>A0ABY7DYJ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YMD3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_009368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="360"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR02810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="637" mass="74514" checksum="4F72EF7D468981B8" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYJ6</accession>
    <name>A0ABY7DYJ6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Guanylate cyclase</fullName>
            <ecNumber evidence="2 10">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_008304</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2 10"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="313"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="13">
        <location>
            <begin position="700"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="952"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="987"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR01746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1021" mass="117118" checksum="1EF908A8BC4D4178" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZZ8</accession>
    <name>A0ABY7DZZ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_008799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR02241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="106" mass="12299" checksum="FC888AB5A7B62877" modified="2025-10-08" version="1" fragment="single">MQGSCFRTQRIIFLSFCCHGSRNVSSFQDKSPQVTMTDEDFKRTFLHQRFFRKLGTKYLGVTLTKNLTWDQHIGVITGKANLTLGFPRKNIKECTPKITKAFYKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2D7</accession>
    <name>A0ABY7E2D7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_009229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR02671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="70" mass="7554" checksum="0F562DCD8DAC074E" modified="2025-10-08" version="1" fragment="single">MKCNGIRECADGIDETICRSVCANGEVQCAGGQCATLCNKMAECIGPDGTVMDEGFVKAMIRLAVIRYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4P5</accession>
    <name>A0ABY7E4P5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PKHA7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_009937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd13248">
        <property type="entry name" value="PH_PEPP1_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040392">
        <property type="entry name" value="PKHA4-7_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057971">
        <property type="entry name" value="PKHA4-7_TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12752:SF9">
        <property type="entry name" value="KRAMER, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12752">
        <property type="entry name" value="PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25541">
        <property type="entry name" value="TBCA_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="822"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1243"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1296"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1352"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1454"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1498"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1584"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1643"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1675"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1742"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1826"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1118"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="649"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="822"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="852"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1247"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1307"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1356"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1366"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1457"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1518"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1584"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1754"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1771"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1831"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1845"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1877"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1919"/>
            <end position="1931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1950"/>
            <end position="1961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR03379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1982" mass="223652" checksum="B1F781713E208791" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5A4</accession>
    <name>A0ABY7E5A4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26108" checksum="2AAC2F4F932FBDF5" modified="2025-10-08" version="1" fragment="single">MKFTKERNFTIFVEGYRYYVSEQETEWGNGNCTLALPSLDYNDLGIFAETEKDTNWTLHEDGLWIGLFQAKLSFAYVGCNKLNDSGAVLSHNICECSWKSECDSFAIRKIDDEKIECKCLDTAVVASKSQCTSTCKRADAYKCGKEGNNYFSIYTVQNATKCFRHCGYASKTCLNRIRRKTSRWAICFQSNRQNKDCSDRPFTVRDIGTKVASSAVAGEKCFAKGLFPATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E649</accession>
    <name>A0ABY7E649_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PFD2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_020018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR04649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="138" mass="15550" checksum="0683E875E352E57D" modified="2025-10-08" version="1">MASKKPPQEQVIAGFQDLRVQQRNIANKVAEVEMDMKEHELVIETLKEVDESRKCFRLVGGVLVERTVKDVLPALVNNKEQMEKMVDSMKGSLVTKGEEINKYRETHNLKIKGEDSKEPEKKEKDASKAGGVLVAKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6L4</accession>
    <name>A0ABY7E6L4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_019802</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd10229">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR04433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2014" mass="236334" checksum="CC1D4C8FDE28F21F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6L7</accession>
    <name>A0ABY7E6L7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR04069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="88" mass="10145" checksum="D41FF1851E6FCDC7" modified="2025-10-08" version="1">MFMTLGSSSIRSSLVLGPAKMERFAIMGNLYWYQVQGQLLVTGADFCDFVTYYWQETSVIRIFPDRCTMEDNSILSKMCLVFCKVFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9N3</accession>
    <name>A0ABY7E9N3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NETR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_016711</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046172752" evidence="3">
        <location>
            <begin position="23"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="34"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR06753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="428" mass="46845" checksum="605487A3B8E93FCB" modified="2025-10-08" version="1">MDLCIIRLFIFVLFVELLIVGCKDMSASAETGAVRLTGGSSPKAGRLEVFYNHQWGSVCDDGVTNNLSRVVCSQLGYHTSHPSVIRYLGYEYDTADMPIWLDSVECRGGERYISECDHDPWGLHDCTHDEDVGINCSTKKRGETTQAGRDQQSQEQFTPYQLREMTNVAYASSSSDDAVRGNVQLGDTRTAVSSNPPDHAQEHYATDLTEIPDLPSYEDAMSNKDRLGQKRLSSTKSVCWADQTTHSGAWWYSTSMNVASSASVATNSCRQSGISIGMYRIGTVSVAGRIDMNRISIGMYRIGTVSVAGRIDMNRISIGVFRIGTVSVAGRIDMNRISIGMYRIGTVSVAGCIDMNRISIGMYRIGTVSVAGRIDMNRISIGMYRIGTVSVAGRIDMNRISIGMYRIGTVSVAGRIDMNRITVLGCIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAH6</accession>
    <name>A0ABY7EAH6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CUBN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_021171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF37">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045465667" evidence="4">
        <location>
            <begin position="24"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="32"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR05802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="154" mass="16907" checksum="E8F361A5B111EE90" modified="2025-10-08" version="1">MEFRVSFIQLLQIVLEIRTVTSPDNVRGGDNCGGVVDLTQVGAMTITATDSDNDGIYDDNLDCWWAFTVDEGTIVFESNFFNIEFQSSCGFDWVQLLDGSGEFLGGQAKYCGTTIGSSFQTTSRSLYLWFHTDFCCVTGGPPTGFNFTVKAVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EB64</accession>
    <name>A0ABY7EB64_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="168" mass="19495" checksum="DB7298E9EDEAE03D" modified="2025-10-08" version="1">MSDTKNLNLKIPYKESTQIPEVKPDKRTANKKAADVWYRASGREQILPDATETCFTYTLLQPSNMPMLSPLKDGINVKSNSPVEPVMSKIPDTIISNNQNLKWKKVDDKEKQRWRLFWKALVCHACRNNFKKKFNIQRCEDLGKNILKDMCWSGWTSRENSPVHPLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECE5</accession>
    <name>A0ABY7ECE5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="267" mass="30162" checksum="76E933C756AC3680" modified="2025-10-08" version="1">MKKTSMQKNPNLNARFVRNIAQAKQFFSRMRLSIVSKRSLLNVKPAAEHIGTIAALKVIEFAVLPDLSSAEEHTNRHIIDCVLYFILADTKPYRRKDLAFVYLILMMTSLCVSILLTCLWYTVFDCGIYTCNDASTSESDSLTVKISVEPQSQQDPEHSVEPSGPLILEPRRKNAQLSGSFDCESEPEYTQATNNPVEGNLRVRIKHTGDSNNPREIVWNSTNIQWVEGPKGPTTTATASTGTTTHYHYSYYHYYTTTIYFSFTIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECI9</accession>
    <name>A0ABY7ECI9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4773 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_017690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031941">
        <property type="entry name" value="DUF4773"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299">
        <property type="entry name" value="AGAP008005-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299:SF2">
        <property type="entry name" value="DUF4773 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15998">
        <property type="entry name" value="DUF4773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045189953" description="DUF4773 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4773" evidence="2">
        <location>
            <begin position="92"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR07732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="225" mass="24498" checksum="5A1107D020B40D67" modified="2025-10-08" version="1">MNRAALTFLCLCVLAPWVRSMSVTKDGFTDMETFTDGGEGGLAKLLELLSLSASVDLNEADDTSDEESVDIADEIIKALAEDIDLDEIVKGCSKGQCNFCNQNKFLKVCVQAGLVKLGFQLSVTVNGHTVYKKEVSIKNPPPFCVNKIPLLKDVTDFCIQIYDVDLAQKSACVKVSFKVKIGHFGQKISLKVGCFKIPHAMLEGMDTAGVDQGSALMFTPYQNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEF5</accession>
    <name>A0ABY7EEF5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="94"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="271"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="314"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="403"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="444"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="627" mass="65906" checksum="5FD3B95EB2535C5B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEQ9</accession>
    <name>A0ABY7EEQ9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DZANK-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DZANK-type" evidence="1">
        <location>
            <begin position="177"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="240" mass="26898" checksum="BA21618B857D05FB" modified="2025-10-08" version="1">MDSENCGIQSCYRRKAAFRLGTGKKADFILGIGERRYTGWAGYRSQAAFRLVSGDMRHPGWVPDKGGIQAWYRSKALFRLSTGERRYLGCVPVSGSIQAGYRSKAVFRLSTKNRNIIEQEGCNRNIMKKCSNRWCGFAAESTFCPECGFEMIDTPTNPVPRYIVIICDGFDIKGSPCGAELKIHQKFCRYCGKEVDTTMFGVQRPNFEKCMGCGNELTTGAKHCHECGLYTQPKARQVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFL0</accession>
    <name>A0ABY7EFL0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">TNR21-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_017539</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052459">
        <property type="entry name" value="TNFRSF_decoy_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23097:SF181">
        <property type="entry name" value="CASPASE-8-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23097">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046289751" evidence="12">
        <location>
            <begin position="20"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="9">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="14">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR07581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="302" mass="33005" checksum="96EEDE3D321EE270" modified="2025-10-08" version="1">MVAWLAFVVCFLYLSKVIGLETSCCDSYHLQRQNGDLWTCDNCPPGHFFVDDCTFNGGSANCSVCPTGYFMASRNVFRSCAKCTENCPLNTIISVNCKFTSDLQCRCKDDDKYLDKDACATKTKCGKGYGANGTKDGNTICVECPEGTVSPNISSDEKCMPDTDDCAPMPCMNNGSCTDLEDDFKCTCPEGFAGRNCEYDTAGIIASIVLGVLYVPTVVIASVALKWSLRRKWKPRNPKNKNVSLQSLHSRQPENGPAQDTNGDTLAESSLRVADVRNGTFKSVKLLNSTDKEQMLHCVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EG82</accession>
    <name>A0ABY7EG82_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="239" mass="27757" checksum="70E219573171C5B1" modified="2025-10-08" version="1">MGDMHKHIFELKKHWEENKELEAVIVDMSNDGAPNQVTKPDIEEDQRRWLIISLCLHNVVSPALRTYVRPIVEAEYKTFKKSHKIDAQQFPNYLKKYPPTKKDMNFESINNNKHVLKVNRKPDLANFDFRIKDAVDFSKLFMQTHMAHYTGFDDTCDQSALLGIIANMDSFPQLLKAAADKCYCQRTEYYFKPKNRGTKPMGSRKFHRLGHSQVPDLLSANDSSYQEHDNAPSPRSSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIV6</accession>
    <name>A0ABY7EIV6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="237" mass="26546" checksum="A1E4EEE953CB4472" modified="2025-10-08" version="1">MSDDTNNASGNESMVRQCKVFLSTDHRGLLFDTVSLSDIANFESYESVLKSVKRIIAMSQKIDARSIDVSGLFYYKRRARSTRMNPVPLVTTTDVFRAIAEHPSGEVPIGVNWTRHDIVLVPKNNSNKTSEVKEELSDGEIPAKKRKIEEMDASGQTIHPSEDTPVTSRPVPVSKVVPPKPQETIRNLSRVPEQKHYSWPTEASCEVLFSYDGVAERKRITNSPLAAVIQRLVHICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIX1</accession>
    <name>A0ABY7EIX1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="378" mass="41744" checksum="E08460998C792A0E" modified="2025-10-08" version="1" fragment="single">MKAKFSWRDVKKQQQNRQKGQGQEEVTHEGQRGSSTQEVHSFRSVIEQDKATSGSQHKDALAISVKTPKPAVKGSPVSSSPASLSWGLQRSNRNQVTTGSPTLKINPTKGVTSPQAWSSAGPTSPESPEKPWSGEIIQSPTSPICSFYDIIEEQAIQDLLIHYKAADSVEERITVEHLKMDDQDMYWSSLPGLSKKVKWPVKLIDWEDAVVPDEFEFEDEDDNESTPKDDFVHYKQTDIKLPDSDSAMKTSDVPPASTYPIPLQVSSEADDNIDIGNILPMDVGQLSSCEQDLDHALETFREQFPFIDSPANSESEDESEIEINIGKFLQSESEDSESDPDCKSDLAEEITSKGGSTIGEALETALDEKINPNAEEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJA8</accession>
    <name>A0ABY7EJA8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WASC3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC53 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019309">
        <property type="entry name" value="WASHC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13015">
        <property type="entry name" value="PROTEIN AD-016-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13015:SF0">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10152">
        <property type="entry name" value="CCDC53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR09027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="196" mass="20133" checksum="FBFF6A7964AE1EE5" modified="2025-10-08" version="1">MDEDGLPLVGPGVDYTQVEAINQKRIIAFVNHFVSHTAGFLNRFSCVCEEKLEQLSHRMQQLDITMSLLEAKINSIPGMENVTAPSGSTPAQSQPGDGGAAPPPSATPQAPPPPGAEAAPPPPPGAEAPPPPPEEPAPAANPGVPETAVKGKMAAEGLNPDLLDTPDAPAPAGGASKNDDFSSDEDNQSDDSSDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJL1</accession>
    <name>A0ABY7EJL1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34999">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34999:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="412" mass="49897" checksum="58E8817D940AC6E9" modified="2025-10-08" version="1">MRNDFIQHTKIESNDYKQQMTLESIDYDQQMKLKSNDFITTFFNISKHDYIQNIPLKSTDYIQHIQLKSTDYIQHIPFKSTDYIQHIPLKSTDYIQHIQLKSTDYIQHIPLKRTDYIQHIPLKRTDYIHHIPLKSIPFKSTDYIQHIQFKSTDYIQHIQLKSTDYIQGIPFKSTDYIQHIQFKSTDYIQHIQFKSTDYIQHIPLKSTDYIQHIPLKRTDYIQHIQLKSTDNIQHIQLKSTDYIQHIPLKRTDYIQHIPLKRTDYIQHIQLKSTDYIQHIQLKSTDYIQHIPLKRTDYIQHIPLKRTDYIQHIPLKSTDYIQHIPFKSIDYIQHIPFKSTDYIQHIPLKSTDYIQHIPFKSTDYIQHIPFKSTDYIQHIQFKSTDYIQHIQLKSTDYIQHIQLKSTDYIQHIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJZ0</accession>
    <name>A0ABY7EJZ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XPP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="1">
        <location>
            <begin position="283"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="363" mass="41059" checksum="43AC8F4FE793C03A" modified="2025-10-08" version="1">MREREIGVPSMIEWLKSVLTNGQTLGASPFLSSSSSWKANEEALQAAGIDMKAVSNELIDALWNNDRPAQPNSPINALPIQFAGVSWENKVTNMREQMAALGTDMMVREYEPITVTRDVDNRAQRATGVLIGYACNQAIYAAIPNKGKIVQMNTPIATTKTMKNSVEVEGMKKSHIRDAVALISFLERLEREECYTRVMMGHINLFLAKFRKGVYGREIDAYARGPLWDVGLVYRHGTGHGIGMYLSVHEEPGYYEDGKFGIRLENIVMVTNASTKYHFPGTEFLTFEHVTLVPYAPNLINYDLLDDKQIQYLNDYNELVRSKVGPELQRQGKTAAYEWMRSKTERYEKINPQTPNTEKFSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELS9</accession>
    <name>A0ABY7ELS9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">H17B6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF50">
        <property type="entry name" value="GH26015P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="147" mass="16408" checksum="E3188928DA2C900D" modified="2025-10-08" version="1" fragment="single">EVNNIAKKSVFITGCDTGFGNILAKTLDHKGILVYAGCLTNDGAVQLNKDSSSRLKTLVVDINDNCCKHKQSYRNVRKFISLLHESNLSNPQDVADVMTRALHARRPRSRYLVGTDAKTHYSLIGVLPEWIGDRMFGWPVPYGDCEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EM53</accession>
    <name>A0ABY7EM53_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_036153</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046447770" description="nicotinamidase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Isochorismatase-like" evidence="9">
        <location>
            <begin position="25"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR11077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="229" mass="25283" checksum="DB814F99561AA554" modified="2025-10-08" version="1" fragment="single">MYMESVMLAILLVLSAVGPALSNLALIIIDVQNCFLSGGTLAVENGDDVISVIQHIRLKYKDQISLTVFTQDWHCADHVSFASQHVGKQPFTAIDLLYTDNGTLCPVNSSCDSTHNISQTLWPDHCVINTTDAQLSSQLEQHPGDIVVKKGYHCQVDSYSGFFDNGGFSHTELDSLLRQRKITRLLVTGLALDFCVYYTSKDGQALGYETYTVADACRPVRKDNVDKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMD9</accession>
    <name>A0ABY7EMD9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="59" mass="6722" checksum="65F9B433A2A079ED" modified="2025-10-08" version="1">MSYDNCRTVHPATTVQPYLIPPPSMSLTVQLVTIQLTLHMLQNTHVHHRHSTTSRMVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENS1</accession>
    <name>A0ABY7ENS1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="204" mass="25680" checksum="C29FF5AE6E8ED822" modified="2025-10-08" version="1" fragment="single">YYPYISTVQYYPYISILQYYPYFSIVQYYPYFSIVQYYPYFSIVQYYPYFSIVQYYPYFSIVQYYPYFSIYYPYFSIVQYYPYFSIVQYYPYISIVQYYPYISIVQYYPYISIVQYYPYFSIVQYYPYFSIVQYYPYISIVQYYPYISIVHPLYDLRIHFLHFPDLARLERYSTLETPLQWHQVVSPPTDNVTYHVFSDTFKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EP32</accession>
    <name>A0ABY7EP32_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ULK4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056981">
        <property type="entry name" value="HEAT_ULK4_RUNKEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045906">
        <property type="entry name" value="ULK4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46240">
        <property type="entry name" value="SER/THR PROTEIN KINASE ULK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46240:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ULK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23606">
        <property type="entry name" value="HEAT_ULK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase ULK4/RUNKEL HEAT repeats" evidence="1">
        <location>
            <begin position="292"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="645" mass="71710" checksum="9FE12BC314206AE5" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERH5</accession>
    <name>A0ABY7ERH5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF5">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="97" mass="11536" checksum="4B900DDFAD2D7C85" modified="2025-10-08" version="1">MSGENKGLQRRIRHHMSYQLYINCRNHKLALCVKHMMAHFPLLENVDSLLLSLLKMFHYSPKKYEMFKDVQAAYGMKNLKLIRTSATRWLSRGHVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ET96</accession>
    <name>A0ABY7ET96_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LAT2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_025809</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF528">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN JHI-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR11629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="442" mass="48482" checksum="EF0C866E155E7A4E" modified="2025-10-08" version="1">MASDGKKKPNIKIEDDIDQIIELKQEIGLKNAVAIIVGVIVGSGIFISPKGVLLEAGSVGLSLSVWSMCGVISLVGALCYAELGTCILKSGADYAYIGESFGKLPAFLYLWVALVIIMPTGNAITALTFAKYVLQPLFPDCDVPSNAARLLAALCITLLTFVNCTNVKWATRVQDIFTVAKIAALIMIIITGIVKFAMNEQVESFEEPWEGTQTNPGSIAFSFYSGLFSYAGWNYLNFVTEELKEPYKNLPRAIWISIPLVTIIYVLANISYFTVLTPREMLMSDAVAVTFADRTYGVMQWIMPLFVACSTFGGVNGAIFTSARLYFVGAREGHLPGFLATISTRNFTPMPALIFGCVLTLIMLSSDDIFALINYAKFCGVIIHCVKRGWHVCFIGMAVVAAGVPVYLIGVVWKSKPRWFYQQLDHVARATQKACLRNNLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETM2</accession>
    <name>A0ABY7ETM2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TCF25-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="572" mass="64677" checksum="E6572A5AADD0D6BC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUN9</accession>
    <name>A0ABY7EUN9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="175" mass="19415" checksum="3C864DB5505F36CE" modified="2025-10-08" version="1">MYGVDFGKPSKACKTRERSVNWSERDKLLAVQLIIDRENELYGPVLGIIKKKAWVCLTDMFNAEADEYRTTRRYLDGEMKSKTPTPSIQVLMEKMAGSPTGFSMKIPDTIPVSIWAGNTDIVKVEVPDCDGSSSPHPLRSEESDSRSNMDEDMTSPSLIKGVPGTSNATFSKSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWJ7</accession>
    <name>A0ABY7EWJ7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="271" mass="30145" checksum="E8FD2E3F80AF6366" modified="2025-10-08" version="1">MSRWRIGEHTSVGATNENRQITYTDTCWQLAFQHDSAGNELQGSLNMLRSAVKRGNRVKLLIGNTSVVPEHVSVRGGHINAMIISKVLKANSNIKEFDSTGVWDWSMVTTTGTQTTLKLRVGEATETADSRVITATEVTWFIDTRPWRKVLAHDKFGTVTSGSKVALRDAVKLGARVRYIMRFDESDSIEVQEADNISINGADIGATHVRSVSLEPTPGSTADRRFQNNPYWWFTIAATTGSVDMSRWTVGEHTNRGHSSQTANIEWFVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EX53</accession>
    <name>A0ABY7EX53_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LAAT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_003952</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR13847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="257" mass="28849" checksum="BB1F40FCCF9B5BE2" modified="2025-10-08" version="1">MPWQPLLFDVPPSNISDNCSQGVQWIYHVLQDCVYDAQGIASEILGLASIVTWMIVSIQGISLLLILMWTLGDTANLVGGILTKQLPLQIYLAVYFVFADLVLFAQFLYYNCYWKKKYKDYEPIPSTSTKSVGVGTSNGNYKRQSTDGLSIMMFILAVLGNLTYGLSILVRQLDVNYILKHLPWLIGSLGVIFLDLSLLVQFKYYEKTDDMNSLLKQPILNDTVLPDEVEVYVPAHRDHSASVNSITTASVNSYTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EY95</accession>
    <name>A0ABY7EY95_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KCAB2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_005013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="111"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR14908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="227" mass="25620" checksum="46D8AF5106CC163A" modified="2025-10-08" version="1">MLTLAYESGINFFDTAEVYAAGKRSSYIVSSKIYWGGKAETEKGLSRKHIIEGLKGSLERLQLDYVDIVFANKPDIHTPMEDCASIYPCYKPGLGNVLGYLQMVTNRNHEQTEYHLFQREKVELQMPELYHKIGIGTLIWSPLASGILTGNWLKDKILSEEGRRQQSKLREVAEVAEKIGCSLSQLAIAWCLKNENVHCVLLGASTVDQLYENIQAIQNFLKYLSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EYU3</accession>
    <name>A0ABY7EYU3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZXDC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_004116</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="398"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="428"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="486"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="532"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="601"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="692"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="697"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="784"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR14011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="855" mass="94499" checksum="613670B1F23C5ADE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZ46</accession>
    <name>A0ABY7EZ46_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HS12B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_004221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR14116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="398" mass="43474" checksum="97A25F802FE16B11" modified="2025-10-08" version="1" fragment="single">AGIKEDKLSLAYEPEAAAIYCKHMRLAKLREPGKDATIQAFPTGLKFLVLDLGGGTVDISAHQVQDDGSLKALREPSGGKWGGTLVDDGFLEIFEGLFGADFMTGLKSDIEQAESKRELDAEIEMKKRTIVGKSNAKANNVISIKLPFALLEGTKSAQFESALESGIYELIQGKLQIDNSILLSAFENSVSKIVEHLNFLLGKTELERLDAVVMVGGFSDSKVVQEAIKDVLENYPNVDLIIPENSASAIVHGISTSAPFVEELHPLSHRVQRDGSNQCEDIFKVFVKKGEEVIPGQTTATHEFNPSPLTRENQTIEVYKSEEDEPPKFVTECQKVGLVCFTVPDSDFDVTTVRVDMKFGGTQMTVSAVVNGPNGIIVYDSNRCMKLGYEDSVLPNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F159</accession>
    <name>A0ABY7F159_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="237" mass="26270" checksum="FB515684C9CCA54A" modified="2025-10-08" version="1">MENVISRTGRVHAFMDFMDLTAKVNVHSISWVTLAWTMVTAIVHQDLTYQRVQKIVSPLVQNALTAVPAPYARLEKYGQFDDQECQCNGNGCDILNGDCTVKICPKTCTSCDDNECCNECTEGRYQQTEETNSGSVIGGAVGGVLGVCIVVALVVVVLVLKKKGIVRKENKKTYEDISPGRSQDEPYTTLAVATMTEYEISDSEPRSETTIEGEDNRVYYNDERAYYKNIGGNIHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F172</accession>
    <name>A0ABY7F172_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GBRAP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_004603</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd17232">
        <property type="entry name" value="Ubl_ATG8_GABARAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR14498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="119" mass="14256" checksum="619CEC224F52B7AA" modified="2025-10-08" version="1">MKWEYKEEHPFEKRRAEGEKIRKKYPDRVPVIVEKAPKARVGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNVIPPTSATMGSLYQEHHEEDFFLYIAYSDESVYEKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1P0</accession>
    <name>A0ABY7F1P0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="20353" checksum="9173A94CB79C36C1" modified="2025-10-08" version="1" fragment="single">MNIKNTPDRQHSNAYELSRKPCLQCVILNQDKNVVPVQLLLSLERKTSADAEQLVRKLEDNCTILSLHQVSLPLKCCRILLFVTHDAKPSAHICMRKAMIAKFRQIFYWPGLCSDKDRTTKAPMEKGRSGNPIERLALEILVPLPEIEQRPLYILVTGDYFSTWTEIFAMRNKKAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3S0</accession>
    <name>A0ABY7F3S0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="310" mass="35682" checksum="66BC7DEC297ADFEE" modified="2025-10-08" version="1">MDKKLVNITHSESRLCIARNMKSQVIEFLSRDDNSRSQPGKADAKKTESGEKQQTRVLTDYVGNLYDKFLSENPGTKLSKTTFQRLRPNNILLTSFISRNTCQCVHHQNMALKIQSLRKLGIRIGQNLEHLIARQDELDNILENLPENVNFKTWKKVESEGKMRMKLKRVDLRSSTNTFRRIPFSVSHHFPEDVLASNEHHDFFMDSTFSSSIVFEQCPSHTLGEMTFVTIWPVDESNVLKEGARRVRLVRMALPDTLRCLLVNVSSLMPLIERHNNIANAKEIAREEWLSIIYTVGLEEVTLIGKTTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F448</accession>
    <name>A0ABY7F448_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTPRK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_031557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="286"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR16963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="387" mass="44852" checksum="D611AF78CDC6594C" modified="2025-10-08" version="1">MQRPKVSVDGLVEYVDSLSQDDIKAAFEKFPQGLIKPYVHSQRVENLPRNRYKGIYPYDDCRVKISDEDSDYINASFIDGYKKRKEYIATLGPMSHQLGGEFEPFWRMVWQQKVEKIVMVTNLIENGTGKCEKYWPNVGTNKMYGEFRITCHSEDMYAEFTRRALTIVKSSEERSIYQLHFTCWPDKGIPDDVTAIIEFRQRVLNTPTTYKGPTNVGIYYPAENMQVLKKGSFEVSSSRETRKSHYAIRSLKIRHTRATGRLSEKTLAHMQFTEWDEIKNVPLSVENFLTFLNDVEETANKQKDGPILLHCFDGAGRTCLFCVVSMLLRKMATEHEVSVLNAVRKVKTMRRLAIPNLDQFIFCHESVMEYLRAFDKDVYANFAGSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4M1</accession>
    <name>A0ABY7F4M1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HPCD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_031716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006108">
        <property type="entry name" value="PRK08259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802:SF1">
        <property type="entry name" value="IP11341P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR17122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="294" mass="31863" checksum="C8348BBE78D38DF7" modified="2025-10-08" version="1">MRTILSKLNSTLLLALRKMSSSSSSKYKNLEIENAGKIMTIGINRPEKRNAVNPETASELFSAFNDFQNDEDSWVAVLHGTGGNFCAGYDLSSLASAPECLLQQMKESNVAPMGPSRMCFNKPVIAAIDGYAVAGGLELALLCDLRVMEESAVVGVYCRRFGVPLIDGGTVRLQKLIGLSRAMDMILTGRSITAKEAYDFGLANRVCSTGSALAVALQLAHSLLRFPQRCMNLDRQSAYYAAYNAASMEDALQYEFDNGIQVVQEESVQGAKRFQEGIGKGGSFNVKNPSNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5K9</accession>
    <name>A0ABY7F5K9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RING finger protein 207</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_004711</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd19814">
        <property type="entry name" value="Bbox1_RNF207-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039320">
        <property type="entry name" value="RNF207"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22635">
        <property type="entry name" value="RING FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22635:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="734"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="737"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="779"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR14606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="795" mass="88567" checksum="3BECCE8097A56A91" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F713</accession>
    <name>A0ABY7F713_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAXC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_032319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026928">
        <property type="entry name" value="FAX/IsoI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01200">
        <property type="entry name" value="SUF1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="3">
        <location>
            <begin position="68"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="2">
        <location>
            <begin position="206"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR17725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="285" mass="33079" checksum="174921117F8D2BCB" modified="2025-10-08" version="1">METLRGFLQDNGKCFLTVAVVLGSAWFLYKKKTRPSYKPRVCGVDYPRDVVILHALRRDRLAPNLGHFCIKLETYLRINKIPYQFDGTSMPRPKEKVPWIEYNGVTMGDSQLIIQYLEQEFKVNLNAHLTSKERAIAWAIQKWIEEFTYWLNVYTRWVIFNDDMFKIQSTCPKYMKIPMRRKVQSMLHAVGVGRHSKEEVHAMMVNDLKQFSAILGDLKYVMGDRICDVDCAAFGILSQVYWCTPSACPGNALLQGGELRNVTDYMDIIRNEIWPDWGDMISKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8G3</accession>
    <name>A0ABY7F8G3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_032248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="174"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR17654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="522" mass="59187" checksum="7164688866F2C4EE" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8S4</accession>
    <name>A0ABY7F8S4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="334" mass="37394" checksum="E544D894E78071CB" modified="2025-10-08" version="1">MKTYSPRSGRESGNLSRKKARTASGVSSVLKISKGMKRVHLQISLSDRRYLVCFAVRNGPARSVQIVYHTGVHGYPRGYHDVLQSDPSKRLSPARGQRQIDASAAHHLHIPDVLSHFVGPAVSEDKAPLDRPKQNGTTKTSNPSDSKQISSTDSNANRADSQTNNPVPRSVAFTLDLDGKETNNALLGPPPPRLKRLDPLNVPKLTANELAEKQRLADEKRESIEESLESAGKSREAKLKDRQLKQQLREQRAQRARERVKKLNDLDQELDIEVEKDEDYNADEVDSWLDGDNNNNNNDSLHSADSDEKIYNGRSSPQKQIKSEKRESKTINKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAF6</accession>
    <name>A0ABY7FAF6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FBP3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_000425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR18587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="98" mass="10332" checksum="5E1989B9F6AF6EF0" modified="2025-10-08" version="1" fragment="single">MPEINECESSPCRNGGVCLDRVNSFTCNCALGFAGVDCSDGNGPTCFSCAHLGMAEKCSSITTCQSDEVCVTETYEKSDGSRRYDTGCQKANVCMSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBL3</accession>
    <name>A0ABY7FBL3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="562" mass="63447" checksum="84533B594D4235AB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCL7</accession>
    <name>A0ABY7FCL7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TCuncharacterized</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10068">
        <property type="entry name" value="BONE MARROW PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10068:SF14">
        <property type="entry name" value="CELL WALL ADHESIN EAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="486" mass="49797" checksum="E3E03268FCA32EBC" modified="2025-10-08" version="1">MGHGSFPGAWLRTLNGHQAPLFMLLYGPGEHRLGSSADKKTGYCSPPTNDVLRSCSTFDQLNGNACKNLSSSMASTPVTNHSSSMASTPVRNLSSSMVSTPVRNLCSSMASTPVRNLSSSIASTPVRNLSPSIASTPARNLSSSIASTPARNLSSSIASTPARNLSSSIASTPARNLSSSIASTPARNLSSSIASTPARNLSSSIASTPARNLSSSIASTPLFHSVDTSLPLLSSSIASTPVRNLSPSIASTPVRNLSPSIASTPVRNLSPSIASTPVRNLSPSIASTPVRNLSPSIASTPVRNLSPSIASTPVRNLSPSIASTPVRNLSSSIASTPVRNLSPSIASTPVRNLSPSIASTPVRNLSPSIVSTPVRNLSSSIASTPVRNLSPSIASTPVRNLNSSIASTPVRNRSSSTASTPVRNRSSSTASTPVRNLSPSIASTPVRNLSSSIASTPVRNLSPSIASTPVRNLSSSIAFTPALNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDE6</accession>
    <name>A0ABY7FDE6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ING4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_000682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="121"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="574"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR18844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="632" mass="71469" checksum="B3B2072A92ED876B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEN4</accession>
    <name>A0ABY7FEN4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apolipoprotein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_002425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the apolipoprotein L family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008405">
        <property type="entry name" value="ApoL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14096">
        <property type="entry name" value="APOLIPOPROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14096:SF28">
        <property type="entry name" value="APOLIPOPROTEIN L, 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR20587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="25966" checksum="0BA5A5948337ED70" modified="2025-10-08" version="1">MATEIIIKNLRSVLDSRKKTVLVLRNIYKECQKAGKKYNTANIFTRVLSIAAGTASVGLAIATPFTAGLTGAPAVVLAGVSAASSAASLGTSFAQTISENGLMKQVHAALEEDRRASARLENALRAILEIQSLALDTTKFAASLAKLGIHTLNKSADILKASGKSMKIVDSVTDAAQLFGKAGKALTTVSKVVSAVSIPVDIMLLIVDLKDCANENYSEAAAKIKNAIEELMQMIAVMQDFLAELEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEY5</accession>
    <name>A0ABY7FEY5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MIG17-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="2">
        <location>
            <begin position="62"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR17816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="410" mass="45747" checksum="5EC458F69659AB6C" modified="2025-10-08" version="1">MTGKNWKIKLTVEDINIAIRQYYSYIFEQIDRRFANIDNKQLQIRIRFSDILILESNTSPPWTQGDPETEVVEARELLSKFQDWVIAKSFLGNYDHVMLFTRYDLKGGGMDSVAGLAYIGGICTRSSVSVVEDRHSNQLVTIATHELGHSLGCLHDGDKDTCSSENNNIMSEVSEISRDLSKNRNSWIFSDCSVQQFQSNLLNKYHDGYGEICALMFCWVSRDSCSFHVALDGTFCGTNKVCSNGFCIGNSDSSKTSAMSAPAEFCPFGDQLPPLEPEGAVCSQVVRDEPYKCYERELYASCCASCNAIHTILPGCEYGDKKSSCASVGRFECLIDSSTCCATCAVYAADLKDWKFPVVVGVVVIGTCLIGIMIYYMVRRLLHKKSRTSGCMVSYTNELPEHQRTQVFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFL2</accession>
    <name>A0ABY7FFL2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CALM1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_032635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR18041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR18041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="160" mass="17792" checksum="B51A6FEFE70A4C1A" modified="2025-10-08" version="1">MSKAKGNSGTTKNSKTKKQKSEIEQIFEKIDLNNDGRISVIELTKAARLLGMNPTQDEAAQMIADCNPSQEGYVNKSEFKKLFSDQKADIDAQVEEMKTAFKVFDKDNSGTISRDEIREVLNMAGEKIDDSEIDEMLQKVDIDGDGNISIDEFAAVMCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FG75</accession>
    <name>A0ABY7FG75_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FBXW4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052301">
        <property type="entry name" value="SCF_F-box/WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14381">
        <property type="entry name" value="DACTYLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14381:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="270" mass="30662" checksum="E553A5E5E6E064B8" modified="2025-10-08" version="1">MDFQSKTTQAEGKIPHPSICLEIIPELPDVALIYIFKKCDIKTLGRICRACKRFRDLVKLDAVWFRFSRYLLKLNSCDIGSKRLIPWMQYNQNVLWISGKNGIRSFDVRETGRPRERKGKRLQLPNRHDVTRFVVTSVTGTGDQDCGPIKAVLNLRERVWSLALAQGGRNVAIGTAGCRGAPSLSVWNVESVSEWAEPYDATVYCLQTDCNVAMVTGTAQHSMVRLWDKRSTQPVQEYFLSQKSPVYSVAFDSRRLFAALDLNTSYLDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGK5</accession>
    <name>A0ABY7FGK5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="342" mass="38932" checksum="C023D0D53DE91EF4" modified="2025-10-08" version="1">MSNYTRAGGRKASTKKGPYSNRNNVQQDANNQSETLGRNENQDMDTTKQRDKTTPVERKGQPTSPHERGEEMMETDETAPPSTTFQTGPKQGSNRPTCQYPVDHDADISHNVGPSSPRHAQAQEMLLRQKEASKQMLYGVFGNVITILEEHEKRTSAIGKGKMKQSDIHIPDQSWKTNEDVKANVETQLLLFQTQSKFCPEEVRLSVNDELRLKTIAWFGVREDSKLDIGETDEFACRLYEILVKGATQHDILDRPRSPVTEKTMRETLPGILRGKHDARELDDSFKKDKNKKAETPKTRQAEVDDAYMMGLSRIERTEPKLKKFLDEDFSLIQYMGPKSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FH49</accession>
    <name>A0ABY7FH49_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HEPH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_002032</name>
        <name evidence="5" type="ORF">MAR_002092</name>
        <name evidence="3" type="ORF">MAR_035241</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="2">
        <location>
            <begin position="84"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR10165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR20194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR20254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="190" mass="21689" checksum="30B3F8AA4C3E3179" modified="2025-10-08" version="1">MYWNYIYFTDPLKDAHSGLIGPMVICKTGTLDEDGQRTDSIKVEFATAFFIFDKNLSHLGTANFAARAPARVDVVDPDFIQSNLYFSINGYIYGNLNGLDMEVGQRSAWYVFGMGMDDDIHTVHFHGQLFIRRTKIKIRGDVLEVYAGTYEMVEMKAYNPGTWFFHCHVSTHVQAGMEGAYRVIPRFTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHB3</accession>
    <name>A0ABY7FHB3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">VAO15-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_014961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD linked oxidase N-terminal" evidence="6">
        <location>
            <begin position="313"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR20987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="486" mass="54197" checksum="1351243648B8CE7C" modified="2025-10-08" version="1">MDATETEKNTLCPPLQELLKQKVFLFRIERSMYFTIPTFYVVMYALSSQAACHNRVLYNTDDRLINFKTRSCESLSRSTGRPNNVYQFYSLFVDRPLTKLRNDLKRRLSDSSLQLYTNSSINSPSLLWSTSTPDLANCEYTIYAGKRIRSPLEAGYKSHPCLKTPAGERAWFTIKEIQLGNNTSIITEPTNNLGNTNKNTLCPPISEFVPENNTMKTTETDSQEYTLSTTSALALLASVALMGWDVTGDGHDREQGSVHNIISERCCPSDECYPSQMDMAALNHDMNGHLLLPSYPEYSKQAHMYNTIEQRYPNLIAVVKNADDIQKAVQFARKYNLHVTVRSSGHDYVGRSTWEGSFLVSLSEMDEMEIDLSTERSPHGTVKVQTGIQWQEIYEKLNTLGRVVVGGSAHTVTPGGYMLGGGHSPVSRSLGYVIDNLLEAQVVLADGSIATATENRTVIVTPVGDIMYHENGDLFWALRGGGGGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHE4</accession>
    <name>A0ABY7FHE4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Decapping nuclease</fullName>
            <ecNumber evidence="2">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_014991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="3">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="RAI1-like" evidence="3">
        <location>
            <begin position="66"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR21017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="235" mass="26838" checksum="CCEE46B5AA9ED839" modified="2025-10-08" version="1">MARFNTDIGRFDYPNSGLNQPEELGCFSLDINREFHDDTSQRKYFIKPLNYDNVRFDLTKGYEGMFAVTLHKGTYYLCECPTDQSLAKIKQMMGEKDEEMCGWGCKFEQYLTANSVPTPDMRYNNCETFYTVVKATIGSHTLVYSGEVDAVSTDEPFGEHYVEYKLRNWWTQSVLVGVPEIVCGLRDDAGIVTKLQTYNTQDLPTMAIARSPAGVFRRGCDLYPASKGLRIRFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHV0</accession>
    <name>A0ABY7FHV0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_000659</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR18821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="403" mass="45879" checksum="37121699653714A0" modified="2025-10-08" version="1">MSGEGVEVPTPGVENLSVAEGNDDFVDPWNVQSSSTAGRFGSQKIDDELINRIEKVTGKPVHHLLRRGIFFSQRDMHQILNLYEQKKPFFLYTGRGPSSDSMHLGHLIPFIFTKWLQETFDVPLVIQLTDDEKFLWKDLAIEEANRLAYLNARDIIALGFDVNKTFIFSDMEYIGSCKEFYMNMCRVQKLVTFNQVKGIFGFGDSDCIGKISFPAIQAAPSFSSSFPLIFNGRKDVPCLIPCAIDQDPYFRMTRDVAPRMNMPKPALLHSTFFPALQGVQSKMSASDPNSSIFLTDTDKQIKNKVNKYAFSGGGATVEEHKEKGGNCDVDVSYQYLTFFLEDDERLAQIKKDYTSGELLTGYLKKELIEILQKIVTQHRENRLKVTDDIVKQFMTPRKLNFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FID7</accession>
    <name>A0ABY7FID7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2A5A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF5">
        <property type="entry name" value="WIDERBORST, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="204" mass="23987" checksum="27D6D7D0B6666975" modified="2025-10-08" version="1" fragment="single">IVYEFFLRFLESPDFQPSHAKKFIDQKFVLQLLELFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNIFLRFIYETESFNGVGELLEILGSIINGFALPLKSEHKQFLMKVLIPLHKAKSLSLYHAQVIKGLLKFWPKTCSQKEVMFLGEIEEILDLIEENSGVILPIMFPALYKISKEHWNQTIVALVYNVLKTFMEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJA7</accession>
    <name>A0ABY7FJA7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047194712" evidence="1">
        <location>
            <begin position="26"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="251" mass="27521" checksum="924571E8F5FD7E30" modified="2025-10-08" version="1">MENIGSGLRLAVLAIVFGVHVFTDASPSIHITQSPSRSEIYVTEKIIVNNTFRFTDVITEDVIITLEPTVDVPDMVIKQVREIRLGYGLYITGDLAPIEDYGNKHLQSKKRGALSIEFHLGNVHNDGKDKGFQADNTFFVQYEAEVLLPLLMGLGHRHQFGASVATGNTVDSLYVTGTYTTTDKPNIPLLFRTLAKQNPAMGDLGTAVNKMTMEQAEGAAIKETTTKIGQKGAEKGKRKSLVQKAVEFPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FK33</accession>
    <name>A0ABY7FK33_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_015055</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">Golgi stack membrane</location>
            <topology evidence="12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="15">
        <location>
            <begin position="150"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="14">
        <location>
            <begin position="279"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR21081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="463" mass="53657" checksum="E7B527C9F63E7060" modified="2025-10-08" version="1">MDYLKGLANVRDRYVNLLKEKDKYEVQYDPRPKSDNDDDDDDAAAADDDDNDDDDLCVLRYELFLLWMIPRSNILPFKGSDNAFAITAKVPHKSFLIHEVKNVSDGALQKHNIQKFYTNKSERRTGLEDLLDVPIKYNTGANASGNLGSKKRILWYNKDSWTSMTKTTQLFDKCTWRNCIATDNFSEVNNADAVIFTVSYKHMGRQPPFKRGKPDQAWIFKLGESPYGRDFSEYSSPEWRNQVNWSSSLNLDSDMPHGAGFIKTRTQPIVKDYDAIFDTKNKTALWLVSNCRAQSKRDLYVKKLQDGGVDVDIYGACGKGRVKEAEINKIIPQYKFYLAFENSFCSDYITEKFFKNYINDWILVTRGGADYRKVIPTQTYINSADFDSPAQLADYLKDLANDRDRYVNLLKEKDKYEAQYGAGWPYFLCELCHRLNHVSEYRHSYPNIVDHLQKDRCFNPTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKE1</accession>
    <name>A0ABY7FKE1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_015481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="41"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="152"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR21507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="285" mass="32213" checksum="CC53C6A893E161D0" modified="2025-10-08" version="1">MRTVYPGLCIKSLHARIQYEDGSPFLVGGSQPQQPQQPPPAPGIIASRGGAMMVKDDPPIPTGSAPRFPKDKDRGLKWQKSLRRRDFMNYLKLWEPSQHDRLCSQHFISGNPSKDPCHPDYSPSVFSFTSPQHPQQTPARTYPGPYPLQREFDQLKADYSSLKIEYQRLLCENRDLKDKMESEKFTYKNLSNNAITSLTGLPSVAVFLWLLTLMSGLIKPTGKLCRDRGFLISDELAAHGATLAIPPFARGKTQFSQQEVECARILYSLEFMLSGQFNELNDFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLW1</accession>
    <name>A0ABY7FLW1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015930</name>
        <name evidence="2" type="ORF">MAR_015936</name>
        <name evidence="3" type="ORF">MAR_015977</name>
        <name evidence="4" type="ORF">MAR_015993</name>
        <name evidence="5" type="ORF">MAR_016006</name>
        <name evidence="6" type="ORF">MAR_016008</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR22003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR22019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR22032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR22034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="47" mass="5565" checksum="5816BD10402D0FB8" modified="2025-10-08" version="1">MEKRGRRRRRPEVAHMWREASVGRLRWCLILHGSFVGLYGSTQPTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FM63</accession>
    <name>A0ABY7FM63_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR23285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="124" mass="13836" checksum="6295656D02167488" modified="2025-10-08" version="1">MDPRSACRLRRAIPCGRPDVRDASDTQRALQQTLLSCSNRVPGGQGEIRQTMERHCNPNVEHTQHVSLDMANTKSTGQRSGTQPTDRQRIRPPSKHVQVVHGSPGRCRVSPNLYISPSSSLHKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQG6</accession>
    <name>A0ABY7FQG6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PTBP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_036640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd12421">
        <property type="entry name" value="RRM1_PTBP1_hnRNPL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="51"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR22971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="303" mass="33074" checksum="73F7AB43B65B21E0" modified="2025-10-08" version="1" fragment="single">VYFQRGSEELMSHSPMLTTNGTGHSPSQNEVNDAKKVKLENSHTTNMTPSKVIHLRSLPNDVSDSEVVQLGIPFGKMSNVLLLKQKNQAFLEFEDEGLATTFVNYYTKMPCQIRGKQNQASQAALQAAQQAVMGNGDGEAVKKTVLRVIVENLVYPVTIEVLSQSLDGQNIYNGCCTLRIDYSKLNQLNVRYNNDKSRDFTNPSLPTGDPGLDQAMAFGGGVRRGSDVGIAGDAPASILGSGWILMADLLHAGKTLSKKKGDICSLLLKCKCFIKENSLAGNETCSSMLFCFHSEEKWLSEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRC1</accession>
    <name>A0ABY7FRC1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CC130-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_038381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR24712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="296" mass="32989" checksum="48EA5FFFDAC92CC1" modified="2025-10-08" version="1">MAERKSVNKYYPPDWDPSKGSVNQYVGQHPLRDRAKKLGQGILVISHIGMGVRYNAEKTKTGMYYTTPLYKFRMKCHLCDNYFEIQTDPKKERDEDVKLASLIKYRALDTYDEKQAKKRKEIEKRPIFHSASKVPKIATPEHKSVNILKDNIKSPFGKNASVLSRTKSSLTKASLGICKKEFKTPGLGLLSMKAESQSKGKKIENPTNFETSKYTNGQEINIVEERLKETDEDIEGEVSGNITDDVSTAAIGDDCGQSSKDNVTVPILLDPLKSKPVQAVSGLSLVGSYSDSDSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUR2</accession>
    <name>A0ABY7FUR2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZN468-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_032366</name>
        <name evidence="9" type="ORF">MAR_038273</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="5"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR17772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR24604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="584" mass="68357" checksum="C51A77CF93708536" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWI8</accession>
    <name>A0ABY7FWI8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_010942</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="11">
        <location>
            <begin position="377"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR25238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="545" mass="62040" checksum="8F4796581F54BCA9" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWX4</accession>
    <name>A0ABY7FWX4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="445" mass="49386" checksum="59ED18215E4B859B" modified="2025-10-08" version="1" fragment="single">ARFLVAGIDFGTSYSGWSYSFKHEFELDPTKVATKNWQGEQLVSSKAPTCVLIEPDGKTFSAFGYDAETKYSELAGNPTECQKCKSREMEIEDETGGTVDIAVQEVTFNGAMKNIYKASGGDWGGTKVDDAYTKFLADVVDIAGVQKNTHGRLPILIRDFEVKKRAVNPLKSDNVVTFRISVTFLEIMQKITGKTLKDLLKGLTHSNQVSLSGDKLKFEIGFIVTFFKPQIDAIVNQVTRLVERQNDSGIEAIVLVGGFSKCPLLQQAIKSNFLKQKIIVPNDGDLAVLKGPVIFGHKPELISQRVSKYTYGVKVMFPFIENVHKESYKVIGEDGKARCKNTFSKHITSGECLDVGEAQVRQVYTPTTSRQTDLPFGVYYTHDKNPMYTTDDGCHCAGTLTVPIEESGYDRDVEVRMIYGGTEIEVETTEVATGKVHRIKVDFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZJ8</accession>
    <name>A0ABY7FZJ8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="498"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR26166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="567" mass="64638" checksum="B6AAD16376196499" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G037</accession>
    <name>A0ABY7G037_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDIB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="371" mass="41712" checksum="66C1FF6469A629DF" modified="2025-10-08" version="1">MDEQYDVIVLGTGLTECVLSGLMSVSKKKVLHMDRNDYYGGESASLTPLDQVYNHFKMGVAPPEHFGRGRDWNVDLIPKYLEFKSIEGSYVFKGNKIHKIPANEKEGLGTIWIPKKTPVRRCSLNLGLTRTPRILTAMELLCIGVRNTRMHRCWSSLIGESCIMNHWRDSGNLRIFTHCTALENCHRDLQDGKVVGVESEGEVAKCKQVICDPSYAPDKVKKTGQVVRAICILNHPVKDTKDVASVQIIIPQNQVNRKHDIYVSVVSATHQIAAKGFYLAIVSTTVETGNPEQELQIGLDLLGAIEQKFVTVSDMFEQIPGTEESNVFISKSYDATSHFETTCDDVLDLYEKIMGEKFDFSQVNLHQQEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0E4</accession>
    <name>A0ABY7G0E4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">THD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_013394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tumor necrosis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471:SF13">
        <property type="entry name" value="TNF FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471">
        <property type="entry name" value="TUMOR NECROSIS FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00207">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50049">
        <property type="entry name" value="THD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THD" evidence="5">
        <location>
            <begin position="96"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR27690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="256" mass="29172" checksum="225D6985175C74D4" modified="2025-10-08" version="1">MRKQLSNCMLCIVFNMPHIKQIDADTEICLHSNDKKIECGKTTRLLQELFEKEIASAYAAAEKQDNIQAQKYVQDVSKHDVQLLTNYKNTLWYKKPYAKVLGNSEEQEHVNGNNAMVTVTCWRHDTDIYQTTGLQRYGIRFQNGRLIVSVSGTYYIYSFLGLTEQRLTDEGIPVDSTKTQEIKHAMHKYSVIDDDDMEIASNVQSRKNTSRGNVIYYVSHIATSAYLHAGDEISVKISDGTLLKQTGSNYFGLHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G676</accession>
    <name>A0ABY7G676_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MEG10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_014250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="4">
        <location>
            <begin position="41"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR28546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="592" mass="62811" checksum="3E58B6BCF10661FF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6W1</accession>
    <name>A0ABY7G6W1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BCL6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_002847</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="555"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR29279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="666" mass="75687" checksum="556C1DFC50CF9C49" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7H1</accession>
    <name>A0ABY7G7H1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SEM5B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_003643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR30075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="82" mass="9042" checksum="A4111FAE917D7F23" modified="2025-10-08" version="1">MRTCTNPEPKNNGSDCVGDANEYKRCDREPCPVHGGWSTWLSWGSCSVSCGIGIDSRDRTCTNPKPERFGDHCFALPAHVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7L8</accession>
    <name>A0ABY7G7L8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HELZ-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="150" mass="17240" checksum="9ED44305B287F70F" modified="2025-10-08" version="1">MITTLELDDCLPPLTSTDGYKYAEPGHLFARIQFKEKLSLESQAGRLILQNTNLVWLSPTSLNSSEERKKVYETKLEYREADNIDVELSEQCVLDLQLRQGQTLEVEVQIQLNRIHLCELHEAVDEIEIPDLVCPEEFPPLDVQISTESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8H9</accession>
    <name>A0ABY7G8H9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-CoA-binding domain-containing protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_033257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119:SF0">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACB" evidence="7">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="163"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR30715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="254" mass="28439" checksum="022A02DC398580FD" modified="2025-10-08" version="1">MESVEKNENHFDSATEFVRSNSNKLGTETLLYLYARYKQVKEGTCNVPKPGFLDFQGKQKWEAWKKLGNMTKEKAMKEYVKALTKDIPDWSSKLQNCGESGDSDKPRSSGNGLGVSVSTMQNDEEDLDDELKTVFDWCKEGDVTKVANILKKNQSCVNLKDDEGMVLLHWAADRGDADMVHMLLSKGASVDKQDDTGQTALHYAISCDHKDVMKALLEAKASLDILDKEGETARDMLSDASKEIQDIVKNFLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9V0</accession>
    <name>A0ABY7G9V0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SPA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="189" mass="21826" checksum="8EF482060820FAAA" modified="2025-10-08" version="1">MTKEGRKEGRKEGRKEGRKEGRKEGRKEGRKEGRKEGRKEGRKEGRKEGRKEGRKEGRKEGRKEGRKEGRKEGRKEGRKEGRKEGRKEGRKEGRKEGRKEGRKEGRKEGRNLSNELKLNSQALYDDDDDDDDDDADADDDDDDDDDVRVNEIAYYGHTDIDLLKHHDGFSAEVEQRLKTIALGHGVPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GCZ3</accession>
    <name>A0ABY7GCZ3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_033926</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SEC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 central conserved" evidence="9">
        <location>
            <begin position="264"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="8">
        <location>
            <begin position="435"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="690"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="793"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="916"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="734"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="793"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="856"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="957"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="980"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1029"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1081"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1109"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1128"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1172"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1195"/>
            <end position="1204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR31384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1204" mass="135251" checksum="CD9DB81831DF8FF5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GDS3</accession>
    <name>A0ABY7GDS3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SHLB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_034196</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the endophilin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd11802">
        <property type="entry name" value="SH3_Endophilin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF76">
        <property type="entry name" value="ENDOPHILIN B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="202"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR31654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="269" mass="29895" checksum="635A6D5BDFA0D7E5" modified="2025-10-08" version="1">MEEMFYEKLDKRKRDRNNVYESLGGVMVDAGNEFGPGTAYGNALVKSGQTQILIGNAYREFKEKKILETKRLDLDSCKSRLRKAKHVASQTQAEADLRQAQSEFDRQAEITKLLLEGITSTHAHHLRCLNDFIEAQMTFSSQSQQYMVDLQKQLGSFTAVPGSQTAPSSTTPNTLGLNSASSTLAPTPSPPSIQVTASTPATEKKQARVLYDYDAADATELSLLADELITVYRLPNMEPDWLMAERGSKRGKVPTTYLDILLSFTFDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GFC1</accession>
    <name>A0ABY7GFC1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="605" mass="68499" checksum="C69C970E3D08875E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GIW7</accession>
    <name>A0ABY7GIW7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PTPRD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_033738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="58"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="313"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR31196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="549" mass="60163" checksum="D8BAD591F6631AE4" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D7K7</accession>
    <name>A0ABY7D7K7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ93661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="152" mass="17460" checksum="D25DF9B1D71CAB7C" modified="2025-10-08" version="1" fragment="single">MPVDLNRNCYICNLFLKFRSRSGGFQKLINIDEQGKPYATKHYHGLQGEENLEFRFDFIVTEHCSFNSGSCFSQPLLIDDDITSSNIQARWSGWTYAMSGMWQYYIEVFKLVPNRDGRLGEATPTDPVYSKTLNHTAGEMSISYTPNEPGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D8C9</accession>
    <name>A0ABY7D8C9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_006402</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="P/Homo B" evidence="4">
        <location>
            <begin position="102"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ93931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="180" mass="20026" checksum="A2EFAC4B0C6BC9AE" modified="2025-10-08" version="1" fragment="single">GRQGLGTAVYVFPARQPGSGLANHIGSITVACLGVNGSVADVSAVNAATLVSVFCNGRKRKDQRMITVGKDKISHTGNLDWYVRVLYDNTLCDTWACIEKMEEVLFEIEFVYSEQHHMKLWAKSPSGTKSTLANIEPFAKTDKARRVRNTFRSNHFWGEKSEGRWGVYIGCNFSAAYPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAA3</accession>
    <name>A0ABY7DAA3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_007060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ94589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="26617" checksum="9FC578ADEC2C6487" modified="2025-10-08" version="1" fragment="single">ADQPPNVPQSNPSVRVSTVPTTRPISSRIITIDQDVVLQHIAAERQFYQDISPTPEMPERIRFSIRRLLEKFFRDHYQENTTRVITSVVFLVVTFSRFIASSVKLASSCDKEQDVAVYLFVKSILGFLFWIAILVLGYKGEITNAIKNPCFEIYSILNALFSFIWLIVGSAWCFGNYTEIKEYCPLLEYNWNYHFINFALFLTAVDWIILACFLFYALYTLCDDPQTEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAG2</accession>
    <name>A0ABY7DAG2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PCR3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_007118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cornifelin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ94647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="79" mass="8596" checksum="36F6834F8F80069C" modified="2025-10-08" version="1">MGEWQNGLFGCFSNCGVCIMTYFLPCITAGQNAEKVGESCCLYGFLSVLGPIGIYTRAKIRGKIRDSKGIDGCRKVVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBS1</accession>
    <name>A0ABY7DBS1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ95114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="48" mass="5567" checksum="32B25227C1FCF7D2" modified="2025-10-08" version="1">MDTLPEKRGMCRPGFTYQAILRNCMPSLGALRGRYRGRGRRGLSSWRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBS7</accession>
    <name>A0ABY7DBS7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DLEC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033304">
        <property type="entry name" value="DLEC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46348">
        <property type="entry name" value="DELETED IN LUNG AND ESOPHAGEAL CANCER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46348:SF1">
        <property type="entry name" value="DELETED IN LUNG AND ESOPHAGEAL CANCER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1461" mass="162363" checksum="99564756809E3A83" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBX9</accession>
    <name>A0ABY7DBX9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="358" mass="39767" checksum="01B46A42A77F842B" modified="2025-10-08" version="1">MAKNECTSTGCTWPVLENSCMYGITSTKWSVLSPVRLLKYDDWGWNSDSFPDIRKHLVLDCHKWHVGPPYIPYVDAAINEEGARCDMEFPLRSPSDAGKGGNTVYRLFASAVTIGEAFCHDATSQPPRFCVKEIIMDFIPFNQNTNLKQSDGSGRKNSPNQNMKAQSFGGSANKMPSFGSPALPFGSPAMNNSGNAYNRTPSPRHQSPYSPRGYNNGHSGRGYNHQGYNSRNSGHFQHNSMSPRHQFSPSHGPPMKYSPYSPVEYQRQMSEPANFKTPQSFGRGNGRKSFTKTFEKTPRFNCNPGGSNSIEDYYNSTMSPPMPTSLLIGNPSLTHLSRIGRCMAEHRPVSVESEVIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCN2</accession>
    <name>A0ABY7DCN2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F149A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_028117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM149 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022194">
        <property type="entry name" value="DUF3719"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039630">
        <property type="entry name" value="FAM149"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31997">
        <property type="entry name" value="AGAP003710-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31997:SF1">
        <property type="entry name" value="AGAP003710-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12516">
        <property type="entry name" value="DUF3719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3719" evidence="3">
        <location>
            <begin position="282"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="650"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ95427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="691" mass="77641" checksum="BCCD15CA31EF252D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DE86</accession>
    <name>A0ABY7DE86_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_028288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="86"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ95598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="267" mass="30938" checksum="1268F83D483799CE" modified="2025-10-08" version="1" fragment="single">KGYLTEQTSMASNFRSAVCQRSDLIYDFVCSPCKDDGLNNEAQFFCDECKKYYGNTCVRLHNKLFRTHSVLGRQEVSKWLGYAGLSPMETCDKHSDRKLELLCEDHNELCCHICVSLTHRMCKSIKHIPDLADGLKKQIDFREIPADVDKIITRLEETIKNRTHSKRSLDDSGGKILAEIKSLRKRVNDQLDEIEKQTNVLLQDQLHKAGDLLQEDIYKCTQLHDKINTYLKSIQSKQDDNTFLAYKKCKKKMRAAERLLQQMQELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DEH2</accession>
    <name>A0ABY7DEH2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="216" mass="24443" checksum="A01C13D6D442BE44" modified="2025-10-08" version="1">MYIAKKLKRLCILCRRWEEGVSFLWEYKESIILLAKKKYNENMATGGGLVGKITLAEESVLEFLKDKPKLIGITGGIESGVREPVEDAASVADLVVQQAPMTENKHISGHQETASVQAIEHPSVSHAHPDESRVMQTNTKKRRRKCMDRIELTEELHGLEVCRAKKGIQLLDLKIAQQLFSMLLRKFISCDFSKKLFALGKMPAKPFQQLKDYNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DEI9</accession>
    <name>A0ABY7DEI9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">M3K2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_005926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF9">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1434"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="637"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="858"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1208"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1733"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1957"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2084"/>
            <end position="2118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2479"/>
            <end position="2498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="653"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="893"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="950"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="968"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1232"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1733"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1770"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1977"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2089"/>
            <end position="2112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ93455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2677" mass="300228" checksum="A67225389D283A05" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DEX2</accession>
    <name>A0ABY7DEX2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="249" mass="28511" checksum="71693682EF1972F5" modified="2025-10-08" version="1">MASDIYVRVTDNEGSEDSPMQNDDEQTKEVVKFLKELRSNLDENRKDLLDNEVKQVTKECKERGEQSLRTISEFMRNFVNVEAVKLGLNLETMKQIIRVFLLCWNKQGLAERIMKEIYDEDENEEPEVDEQMPAEVKGMDNDAINVYAKALSQGWKNLTEGDPVFDELRAEVKMLAEKQHYWNEKSPTSFVQLEKSLDTMRAEGKELGKMLVSGQGAAAANEETRDLGDEAMESPEMDTQTDSYVNFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHT2</accession>
    <name>A0ABY7DHT2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CNBD2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_029936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011:SF28">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="275"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="758" mass="87495" checksum="39C9CCA39419E79B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIM2</accession>
    <name>A0ABY7DIM2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Large ribosomal subunit protein mL62</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptidyl-tRNA hydrolase ICT1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_029146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family. Mitochondrion-specific ribosomal protein mL62 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006718">
        <property type="entry name" value="PRK09256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110916">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ96456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="205" mass="23839" checksum="A23F440694EF42BE" modified="2025-10-08" version="1">MFSLHLRNFVRLEQKLIQNHLLSRNSSFKSGIALDKLYEKSDNHPTSSEFSRTDSKSTTEDGLAEQFTGEIPIKDISIQSCRSSGPGGQHVNKVNTKVEVRFNVNSATWIPEWVKPKLLEEQQNRVTKNGELIVTSEKTRKQILNQADCLDKIRHMIFQASRKPKELTPYELELIAKREEAAKKRNIEDKRRRSLLKMRRRGEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLN3</accession>
    <name>A0ABY7DLN3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="421" mass="47252" checksum="3E9D1A6D276326E0" modified="2025-10-08" version="1">MPRVVQVSSTSNLNVNTRDREQAEDFTDADDGFNKNHNQQEHCSLSFDALPQYLQFPIDYAAYNVVYCPSDNDPYCLHCEVGGEVVKYKKDARIWLHKSSDNNRIHASKNTNTPETRKATANEDDSNYDDIKRRLGKIQHYFQNVCASNVGYTHGPYRTAVGIDSDISSLGDSDADLTYSEESSPSHSITNTNIHTTKLDSRVTFADINEHANITQNESLSNTSMILETDIADPSEIQVDVSDSHMCTENASGNNSRSGLTSCEVARRLAPAIDMEHESLSDGLLDSAVNSFITDHTVGAFRRRRQRRGTGVPYTVGGPVTRSRRQAERDKMAFYNLRSRPVKHKRRQSEKCISYARPGCSRCDRFQQDKNSNTNSNVDSESEPIGDVIHYVTVCNNVPKTYRVPTLTTIAAEVLKKLHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNR2</accession>
    <name>A0ABY7DNR2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_022081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="162" mass="19111" checksum="E1A590D1E2DE943C" modified="2025-10-08" version="1">MASNFCTLSLGQLKTELRRRNAKLTGRKKELIERLEAYDRNQNFNREEDLLPEFNMSLPKTSGYRDVNSDAKMAPITMEKAIEYMDQYRVEFDGKVKDLYDDKFLLYMRLFSTPSLDFVRGACKAEMRKKTFLYTRMDIFMKHSVNVVQEKAHLDIANILEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DR02</accession>
    <name>A0ABY7DR02_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.60">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="79" mass="8817" checksum="4673279CD5D7EF40" modified="2025-10-08" version="1">MASTERCESKLSLVSNLSMIVSDTPSKHLVEITNLNPDTVTDQRKKAARDILAKYDHDSMMKISNAMTSLYDWAKAVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRM8</accession>
    <name>A0ABY7DRM8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="85"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="286" mass="31862" checksum="BCB6DFF8C71570B2" modified="2025-10-08" version="1">MGVDLQIYRQRIGGFNGYRTSGSAQSTEGTRASSISWRDVLGAVGFIGMLLLMAGIESNPGPGQYPDRGLTPKDIAKVSQYITLNWQLLAVEFDISTVEIQRIEMENSSVALRVNRMLNLWTDNKRDGANVSTLLTALEEYPSISVNWEEVAKVFGVDVLHQRQKRVCTICRACHAVTTFAASCGWLMTSLNFSLSRMFSYSSLLHIVVQLPYTVSPIECLSPVPIVNKQLSSLRQSKATDLYSTTTFTMRVVYEYRPNSHGNLGAFHCFRIGLQRIRCTGAVTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DS08</accession>
    <name>A0ABY7DS08_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MESH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_024552</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056619">
        <property type="entry name" value="C8-3_MUC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF64">
        <property type="entry name" value="DENDRITE EXTENSION DEFECTIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03782">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23263">
        <property type="entry name" value="C8-3_MUC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="948"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="9">
        <location>
            <begin position="49"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="8">
        <location>
            <begin position="442"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="10">
        <location>
            <begin position="604"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="978"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="995"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR00180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1011" mass="112165" checksum="2D16EDBF5FB37183" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DS82</accession>
    <name>A0ABY7DS82_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein zwilch</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_023326</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the RZZ complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Chromosome</location>
            <location evidence="1 9">Centromere</location>
            <location evidence="1 9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ZWILCH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018630">
        <property type="entry name" value="Zwilch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15995">
        <property type="entry name" value="PROTEIN ZWILCH HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15995:SF1">
        <property type="entry name" value="PROTEIN ZWILCH HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09817">
        <property type="entry name" value="Zwilch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAQ98953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="394" mass="45133" checksum="1E34A5AF8B55A176" modified="2025-10-08" version="1" fragment="single">TVCKPAAAKSVHVKLHPSFSSPDITCKAKYDIHTVSDDKAKPDQQSFIQLELEWKILSSQTFMLLHEPHLQARTEVEILRSVIEGLDTSEVNWLGTQEQPLLEDVKELVEKLKLGSDLVECKLGETTFVSLDETEIVSLEQIEERKDLDFTDHLWKILQACTSYVELVDTFKYVVAELRRGDFQPFINSHNTTTVGQMVKDSYRGQLRTPLLTGLSPLLYLAEMGVQKLSRDYLHVFLSRHLANMGMLDYFLKGNLELEDKLNRLTKLHHSLETVVMLKKYLNLPLECLAKCCREMLKYYESHAVENSHRFAFSVPTTAISNVFEKFTPTEWSVEGVKMVGRERERLVYHFTTEQPCDWVKLEGPTASSKDGAEDEEDAFYFLTILTDSVSILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DS85</accession>
    <name>A0ABY7DS85_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWA3B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_024336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd04508">
        <property type="entry name" value="Tudor_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032770">
        <property type="entry name" value="DUF4537"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46785">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46785:SF1">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15057">
        <property type="entry name" value="DUF4537"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="314"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="372"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ99963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="631" mass="71473" checksum="11381FD79A7D0798" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUE7</accession>
    <name>A0ABY7DUE7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="72" mass="8140" checksum="B50B63B3C1E301FF" modified="2025-10-08" version="1">MVTAGTFYDLILHKYTKRCVYDHTANAWTINIGCVNATVRQIASSRETLCLIIKSGSSLSDKALNKWIRKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXA5</accession>
    <name>A0ABY7DXA5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA 3'-5' helicase Q1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_008935</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd18015">
        <property type="entry name" value="DEXHc_RecQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="89"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="267"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="516"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="563"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="592"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR02377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="680" mass="75692" checksum="7D8FD3A99CBC16A3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXQ1</accession>
    <name>A0ABY7DXQ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PWP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_025291</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="333"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="375"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="461"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="725"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="814"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="839"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR00919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="850" mass="94678" checksum="46F36CB269485FA8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXQ9</accession>
    <name>A0ABY7DXQ9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_008823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="27"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR02265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="332" mass="37747" checksum="EC13DB3845FF2F4E" modified="2025-10-08" version="1">MGWCDRVKVIAPRKGNVKRQRVLTADHVTAHLCISADGKVLPPCIIFKDSFPHRTYKDGVPGIWLFATSIIGYMNTDIFCQWFERCFLPNCGRARPVVLVMDNHNSHVSLPLIESARANQVVGGFTRTAQPHLLQPLDVHINGPLKEKVKTVCRNLGLYRCGVNVSNAKLQVVLAYALDQVTPSSIKEAFRRSGLYPPNRQAIPEEDLVPSSFQVQTPDENEPPRTCGTCGHFLAHLAEILVPPPVLPKPQRISSRSVTAGRVISGDEMLRALQDKAAEEERKQVAIEERAKQREEKRKRRLEEEEERLVKRRKRDEEMIQKEEQKKRERAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DY78</accession>
    <name>A0ABY7DY78_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="146" mass="15983" checksum="3BD30C4DA2022552" modified="2025-10-08" version="1" fragment="single">IVGTGNPQYISTGLYYYDGTGFQRIRDPQLPSETGPMAMHDDGSDYLVVEGAMSSDGHASERPESVNTNVDSIYPGRRFMAELSRRVMANPGHDVNVSTSMTDIETLNVSINVSLNIAELLRSYQDSTNGNRNTSNNTENETSTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZY4</accession>
    <name>A0ABY7DZY4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CP2U1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_009856</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF403">
        <property type="entry name" value="CYTOCHROME P450 306A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR03298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="277" mass="31340" checksum="2F7CC775E3DB2984" modified="2025-10-08" version="1">MVVFLLKCETSKYQNINLQLISKRTAAIERVKRYLSETIGDHKASFDKDNIRDFIDLYLKASREDSEQQLFTEANVYKIIVDLFLAGGETTGTSLDWALLYMVVHPRVQERCFEEISMVVGTGRPVCVADKNALPYTQATLLEIQRIANTLTFSLPHVANSDSTLFGYTIPKGSIVIANLYSAHQDPKYWPDPDSFRPERFLNSDGKVARKDGMVPFGNGPRLCIGEPLARMELFLIFTNLLQSFRFCPSPDTEYTLEGTQALTFTALPYDIVVKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E063</accession>
    <name>A0ABY7E063_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_008362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="103" mass="11682" checksum="31D6876102DA1F5C" modified="2025-10-08" version="1">MDKTEAEWDGMTEGEYGNAPMAVVMKTRAARAFRHGEDGWEAIHVCCVHIFPRTECLKVERRGRNNPMVPARRRWCVGGHGCVAKVLTGELETLQLCYFTVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E135</accession>
    <name>A0ABY7E135_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RIMB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_008692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057950">
        <property type="entry name" value="RIMB1/RIM3A-C-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040325">
        <property type="entry name" value="RIMBP1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14234">
        <property type="entry name" value="RIM BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14234:SF19">
        <property type="entry name" value="RIM-BINDING PROTEIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25566">
        <property type="entry name" value="RIMB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIMB1/RIM3A-C-like N-terminal" evidence="2">
        <location>
            <begin position="60"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR02134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="169" mass="20432" checksum="8AF8850A9F015ECD" modified="2025-10-08" version="1" fragment="single">MECMRERNHDDYNDDDRYGEPPSYEDSRGFAVGDYWNLTTYGRPETPQRFKNRKQEERDRQLQKKVSELQTQTQRLERKIALLKTENETLKRKQDDKKPLEEKIKTLKKRNAELAAIARRLEEKAKHLQQENVKDQMKKLFARQRAKDLSEHAKQMLSKDREIEDLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2P2</accession>
    <name>A0ABY7E2P2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047430421" evidence="1">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="82" mass="9034" checksum="D91D619484F694E2" modified="2025-10-08" version="1">MNPVYMCFVIIYLDIVFMAIGSDSARISGYGKVISSLADIFCQAEKESITANKKGEEKRIAKPFNVLLGRGKTVTFKPLSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E376</accession>
    <name>A0ABY7E376_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="82" mass="9525" checksum="522562A75B4CA37C" modified="2025-10-08" version="1">MKQVILALMPLFPYTNIVYSCILPRLNWRYSFNDKIMENSRDRAIKHSDFNDIWPGLFLPDGVHLSPVGNNIFLSTLRSAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3B0</accession>
    <name>A0ABY7E3B0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HARB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_019897</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="183"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR04528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="304" mass="34556" checksum="53C684CB0F624858" modified="2025-10-08" version="1">MADRQLDRYYRYRRFRLPRRPRVFTDRNNPLEILDVESVRKRYRFFPDSIMILVGIVEPTIGTATMRSNPRPPLLTVLCCLQFFATGAHHIVIAQAHGVSRSAVGKAIHAVSVILAGLLNRYVKFPTGLEIESVKRKFYSVAGFPNVVGAVDGTHVKIQAPPDNEADYKGLSFPECTGQIDGLLLGDSGYPCRKYLMTPYANPRNLSEERFNTALCRTRVLIEQTFGMLKRRFAVLKYGIRMTPDRAAVYVASCAMLHNFGFEYGDVYGRQTYEDDDMPQVDNQGVDVNGRTQRDYITQRHFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3U8</accession>
    <name>A0ABY7E3U8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="616" mass="66043" checksum="2D64553BB02BAD62" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3Y9</accession>
    <name>A0ABY7E3Y9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_020086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="3">
        <location>
            <begin position="12"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR04717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="709" mass="81021" checksum="1F81E4E2FAA2A089" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E611</accession>
    <name>A0ABY7E611_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="167" mass="19018" checksum="51542F18CE7280DC" modified="2025-10-08" version="1">MKCLDADLRAFQRKKIPQCQEDVSHTRSTQLEEDSAVSGGREPHTLHADEDSAVSGGRKQQTFNAVGIQSDEVTGRRLESFSEDEDSAVSGGRKQQTFNAVDHRKETTYAFVWIEFGTFSLNVYTIVPPPREEKPKDRNDPTRKVHQIGYAEQFQTYPSIIVNRWKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6R9</accession>
    <name>A0ABY7E6R9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="129" mass="14516" checksum="763F1DBE28058A80" modified="2025-10-08" version="1" fragment="single">NHPLLLFSEFNIDADNVEEQDLSLTVPTTCVFPSISDNITVTWFGLIENIFQQLDLDSASSFIKTVNETDACSNGTCNAKLAKEKTSFGLNFSETIGQYVYSVIEVRIVHSSFNEQPLKWRSSKQYPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ED71</accession>
    <name>A0ABY7ED71_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">KIF25-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_016943</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF63">
        <property type="entry name" value="KINESIN FAMILY MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR06985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="212" mass="23006" checksum="DD8DD336E78027B2" modified="2025-10-08" version="1">MFIYLYAEAKRLKLVLTSITENHIRVEKYIIIVFNLKHTLPFVCAAPPGGRDRRGRSVSLMSTPSFEPPAPAPLNHAIIKTKLQLVDLAGSECVGMSGVTGAALREASHINKSLSALADVLGALAENRPHVPYRNSRLTHFLQDSIGGNAKLLVLLCVAPAQRYITETTQCLGFGQRARQVQRGPTKRRLPSSAEKVGGPDRPGSGGKVSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDI4</accession>
    <name>A0ABY7EDI4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="119" mass="13624" checksum="042FFA9475FEE0E8" modified="2025-10-08" version="1">MHVQHLYSVGKKRAKRPGRQNDTNVLQHVTREADSTPREEVTYAEVVKPRTLMTNRKKAVTKTKEKTTDTLIYADIDIEHLKAARTAVTKRTPSAPTEYSEIRFATRSTPARQENIYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDM7</accession>
    <name>A0ABY7EDM7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="229" mass="26077" checksum="074B30222C1211EF" modified="2025-10-08" version="1">MMFWPKSPCRIPADGITKHMRCLLVWLSIANSIHCTADFVGALWYYRVVQEKANPQHHLHGLCLAQALVCVFGLGFRVFGETGHLYSGPWCWIKKGLPQGWKIFWISVAGVAPEAPQEADTLQDADRTFFCVVWIIFYVFRVPGTINFILEIAYPGSHKEQLNYIKNVLMGMEAFGDDAQAFGNLVFLVIFNKEVRAWLSCKRNCVRPRNARDERSSLIQSTDNHAEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDP8</accession>
    <name>A0ABY7EDP8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGRL3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_016885</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF347">
        <property type="entry name" value="FI21270P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="8">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR06927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="387" mass="44394" checksum="CC3D7490B4B613B8" modified="2025-10-08" version="1">MEKYIIRAQHIARMRLISATMDMNWLEIEFDSVRHQGFGEGHNRLVLPKSFMESASNLFDPSNQESWKAMKETVRNRNGNQNEINGPVLSLSLDPDIKYLDPPIRITFGHFLTNLSEPSCNYWTFGEDDLAGGWSTDGCSVEFSSQNQTVCKCTHLTNFAVLMSPFEQADADSIPLRIVSIVGIAVSMFCLLLTSFLYICLWRYLKNDRAVILLNLCIALLFSYIVFLAGVDRTESKLLVIYITWCNMGVRGACLAHYIEKHTDDEKSVDTKWMSNETKTYVRNEVYVQNNIPSRFESRDNDAQINWRNLVLNRASETDEGRQFNSPIGGGGFGHIHRPTVAFNPPAEYSPHTHDSRQSIKHRDFGNIEFDRGEDNNYDYRRRSTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDY2</accession>
    <name>A0ABY7EDY2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutathione transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GST class-pi</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_016904</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Pi family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003082">
        <property type="entry name" value="GST_pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF141">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01268">
        <property type="entry name" value="GSTRNSFRASEP"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="80"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR06946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="203" mass="23019" checksum="550FC742A64A79E9" modified="2025-10-08" version="1">MPIQLYYFQLRGRAQAIRYLLIDNGLEYEEINVGPEWATKWKAETPFGQCPMIKDGDLKLAQSCAILRYFGRKAGIDPSDLVSAARVDMINDHEEDIRNAYVKLIYQNYDAGKADFVKDAAAKVKFLEDLFKAGGNEFILSKISWADYNLFDLLDILCILSPGFLDQSPSLKAYYDRIAARPAIKAFRESDRNMKAVNGNGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEX8</accession>
    <name>A0ABY7EEX8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1232" mass="141174" checksum="CF282C1AD00FDFD4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFS1</accession>
    <name>A0ABY7EFS1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15158" checksum="14B9A2BF26813693" modified="2025-10-08" version="1">MSGGRQAEVAVPASEPITSGDGYHNQNLNHERSYQPALTCECTRHDIDPVCTTDGQTEWFGCLAICLGKTALSKSTMCPDGLTLVATLILFPSSFVVLSQTAPPPPWQDYPTWDDYDPFSILKYDSYMCADRRTFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EG31</accession>
    <name>A0ABY7EG31_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="192" mass="20808" checksum="FC941C79012D34B1" modified="2025-10-08" version="1">MSTEKGEDIIVYTAKGKTSARKILLTTPSNESDMASILFHVGDTLKHRVNIVGVPCQKESSSPGEALLSISGGATSGDQKETMAVNSGRAKDSDAGNLPKPAFPSSGMTSVPAYKKLLSNTSLKVLANAIAPNDVYTLLIQLEVPPVKIDQERLNNPGDIGQAKKKKKKKKKKKKKKKKKKKKKKKKKKNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGS3</accession>
    <name>A0ABY7EGS3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HKR1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35378:SF3">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35378">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="4189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1561"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1577"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1658"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1675"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1847"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1857"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1875"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1891"/>
            <end position="2084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2085"/>
            <end position="2094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2095"/>
            <end position="2140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2149"/>
            <end position="2511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2520"/>
            <end position="2619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2627"/>
            <end position="2700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2701"/>
            <end position="2710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2711"/>
            <end position="2847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2856"/>
            <end position="3029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3030"/>
            <end position="3053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3054"/>
            <end position="3267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3268"/>
            <end position="3284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3285"/>
            <end position="3330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3331"/>
            <end position="3340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3341"/>
            <end position="3365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3366"/>
            <end position="3386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3387"/>
            <end position="3554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3555"/>
            <end position="3564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3565"/>
            <end position="3736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3737"/>
            <end position="3758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3759"/>
            <end position="3792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3793"/>
            <end position="3802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3803"/>
            <end position="3855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3856"/>
            <end position="3870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3871"/>
            <end position="4188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="4221" mass="410501" checksum="B60BFFD32D57E3DD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELS8</accession>
    <name>A0ABY7ELS8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_036016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="325"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR10940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="708" mass="79292" checksum="54C74BC72806823B" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EN36</accession>
    <name>A0ABY7EN36_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="193" mass="21500" checksum="3CC353DE56AF7C5B" modified="2025-10-08" version="1">MYSLGPSQIVFEESLIVFEEECKSDLKRNVESDLKRNLVTESDLKRNVEVAVCTVKVCDEDVAIKVITLDADSQRAKVTLWRESETSDVRPGDFMTITDVVTVNHYKGKPSLSTTNRSTLKIGLKPKPGKCLVSDVHYLEHSVGCHDVPSCRHVLTTCKPPRRASLCLAATTPTQNSARNACLAGWLADWPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EN45</accession>
    <name>A0ABY7EN45_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DIS1B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF335">
        <property type="entry name" value="EGF-LIKE REPEAT AND DISCOIDIN I-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="62"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="178" mass="20031" checksum="E14094FF108EEA4D" modified="2025-10-08" version="1">MTKCMISTCEFLFQGYLGSCMDHTCPAGTICVSAPSGTMARYSCLQQDNCSIAMFCPATSDIYGQVQFNGLNNVVGVALQGRHDYDQFVTAYKVFYSGDCVFNGNTDKDTIVTSMLPSDVTALCVRLNPVKWNEHISLSVGFERRRRQLSLEENCFEKERTKYVYSMLITFLFTPTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPC0</accession>
    <name>A0ABY7EPC0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_018999</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="1"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR09041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="457" mass="51988" checksum="4AF40B80F373B2F4" modified="2025-10-08" version="1">MGSADMYNGEELVNYGNVILVTLNYRVGPLGFLSTMDEICPGNFGFWDQRLALEWVNDNIGYFGGDSERITIFGESAGAIGVALQSMYPGDNGKLFQRAICESGVGSVSFINYTRDTTYMVNAIAERLNCMARSNAEIITCLRHVPWKKLMEVVMDLNENQTRLEYINFDPVLDNDFIKYDPKELKKLSSDRNTEEVEFFRSIDFMNGFNQYEGGMSLLYFIAGDMDVFKPTFSDFVDLIPDATFVIGEVPIEVVPLIAHEYTDWKDPYNYENIRLQYTHLHGDLQFGFPAVETSLLHAGGSDQNRKSYMFHFLPSPTNRFSITPTWLPGADHGEELAFVFGLQSDPGIKQWELDLSRKMMKYWSNFAKTGNPNAEGQDLLFWPEYTLSKQECMSFDKTMDNDSVKQHFYAEKVEFWTNVYPTIIKALEGDRTCPPNDGPVNGVGSRINKVDTTQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQF5</accession>
    <name>A0ABY7EQF5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047155305" evidence="1">
        <location>
            <begin position="20"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="121" mass="13433" checksum="CB8921A5F1AAF2CE" modified="2025-10-08" version="1">MKTGFIVWLLAVTLSTTESVSDGFCVLSEKTDGQSNKMTRFLLKQSTQNEVTDDALISVSELTEEPCINNSTVEYRLEPSDLLVLKFEGTFQQLNSTSTAANVNVKYNRNAILENLLVYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ER86</accession>
    <name>A0ABY7ER86_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="754" mass="78890" checksum="7D9F0655EBF17B86" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERA2</accession>
    <name>A0ABY7ERA2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LRP12-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_025837</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042333">
        <property type="entry name" value="LRAD2/Mig-13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR11657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="160" mass="17983" checksum="E4E69300D5D2AA4A" modified="2025-10-08" version="1">MDQYCGSTIDMIMEGIDDGKLVIDGYVNQRDCNVTIETWYTADRLHFQFEDFDMGSGICDDTYFTVYDGLDRVCGSGGVEGDFTSSGRYLTFRFKNGGDFSYNQMTLVFTAYHTGYCYSYEYSCDNGRCISEDSNCNGYDPCGDQSDCRLGVGEITGPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERP3</accession>
    <name>A0ABY7ERP3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lon protease homolog</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_025802</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR11622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1020" mass="112834" checksum="BFCCBD92C73D5349" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESE1</accession>
    <name>A0ABY7ESE1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_027063</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="4">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR12883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="278" mass="30867" checksum="2B04620DF6B387B0" modified="2025-10-08" version="1" fragment="single">IVLLFTSGQVRGRQFKTSGAGKARKQNMTARYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGKDIVVLGVEKKAVAKLQEDRTVRKIALLDDHVALAFAGLTADARILINRARIECQSHKLTVEDPVTVEYITRYIAQLKQKYTQSNGRRPFGLSALIIGYDDGPHLYQTDPSGTYHEWKANAIGRSAKTVREFLEKHYTEEVSGNDKECIKLALKALLEVVQTGGKNVELAVMKQGQPLKMIDAEEIDGYMAEIEKEKEEEAEKKKAKKGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESL5</accession>
    <name>A0ABY7ESL5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="263" mass="28603" checksum="F6EBE07E8408B6F2" modified="2025-10-08" version="1">MPEQNYCAAQVDEACDMVESALVQLENICEEQEFQRNERQEAYGEQFAQDVDFFKKHGKPGRLPSTSESEKQLDIADIEIEDDPEALDEFLASTASDTELSEAKDASESDLVSDTDAPSAQIISDITSPDIENSTFEVGSLAKDSSETSEVTAPAESVSSSSNEGQDGGAHKNKTVELTEDAISKDKQSETAEKRDDDGKEMEGPEESENAEKNDDEMEGAQESGKATSPDEDVKEEMEGATDKQSENNEMPSDAVKDTKSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESP2</accession>
    <name>A0ABY7ESP2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="166" mass="18989" checksum="B810ED5B8986C7F4" modified="2025-10-08" version="1" fragment="single">KCVKRILQQWPALCSYFESHEEGEKLGRVQRTKETLTDPLDVAHLFFLGSHHSLDDKFQHYLPGWRPHGWPPSHLDAAPDEKPPGKVCLHTGHCSCKRCDILGLKTRQNLQENEETLPPGTSAKFFRLFYTSLASSLLKKFPFNDDILKTLSYLNPETREKTSAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETB7</accession>
    <name>A0ABY7ETB7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRI33-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_026226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR12046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="219" mass="25006" checksum="CC55DEB843ED1B45" modified="2025-10-08" version="1" fragment="single">MASKHTKSFKDSMSMASDLIHDFVCSPCQEDKLNTEAKYFCGDCSKYYCDKCLTFHSKIHKQHTVLGRKDVDKWVGQGDALISCDFHPGKVIELLCEDHAEMCCHLCVSLNHRMCRSISLISDLAKGVYEMADFRLLPSKVAKVTTSLNQVREVRKKNQVSLKACCKYMLTKIKDLRKALNQLLDELEKRTVKQMDSVLADLDVTLQKDIDSCTHIYDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVN4</accession>
    <name>A0ABY7EVN4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF3">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="120" mass="13418" checksum="179C476BD75ACA9F" modified="2025-10-08" version="1" fragment="single">VLHSQRLREKPLQPWVIAKPDGVFVAAHCNCMAGLGEACTHVAALLFYVMAVVEENTKHACFLKASYSDFISFYEKAQQLQKKPGLLSVIDPFADEFISRADKLDLPEQLTKLRDPDLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVW7</accession>
    <name>A0ABY7EVW7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="181" mass="20738" checksum="9A92DD369ADE04B8" modified="2025-10-08" version="1">MEAITLGNHGDEIHKAQHAGMHDTSTKGKVHTPKAYVNNEHMEEGRKKNEQCTSTLRIFIQSESHNDKVNNAQTHGEKVRKAHTQRNKDHKTQATATKLQKARTWTMYTCQIYMGTMNTRKIHWRKVQKTHWHGDKQGTAEVHRNKGYGVKSGANTQMINSGVLLGAFKYPQLKFPVPTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EY80</accession>
    <name>A0ABY7EY80_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ST1A2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_004998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="96"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR14893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="376" mass="44626" checksum="2764B9D0B25C1B64" modified="2025-10-08" version="1">MGRRFREKGSPEYHLYRKMNTDSDDVMLMAGDVARRRRADDVKRRSFRPEIQSQATQTEFQVERTHWVWEIASMLLQGKAETIPKRKSKNMLENVPQNELNDIPSPRILNSHLDFKFLPEQLFEKKCKIIHILRNPKDMAVSFYNHVKGITCYAYDGEWQHYLKLFLEEKLEYGSWFGNVLSWETFVKANPSYPVHVIYYEELQKNNVSEIERLAKFLGVDFNDQLVNMVSEKCQFSNMSKDKLVSDDLRKLLYKGNFTMYRKVMYCVVYKGDFTVYRKCENTVMYCVVNKGDFTVYRKGMNTVMYCVVNKGDFTVYRKGKNTAMYCVFNKGDFTVYRKGAVGDWKNWFTVAQNEEFDRVYNQKMKHSALSFQYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EYB6</accession>
    <name>A0ABY7EYB6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="127" mass="13957" checksum="A7CEA6C0A3A15DBF" modified="2025-10-08" version="1" fragment="single">RIILLHVFQSFTRLPGTMPSCVPANNNNVGDVDAVKGPPQSDSKISKLITCLFFRKKTGVVDLAKESSAAARKKQRMTVDRSERSRRVLKMESMRTAPKPRDDDDAGRPSSGQGPTQMFLPSENPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EYL6</accession>
    <name>A0ABY7EYL6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36884" checksum="94E5A60E548E72A5" modified="2025-10-08" version="1">MASKQIQCEMCGNENAVGNCKSCGYVGEACVDIHKSVNVFQTHTVIMHEAVKMHEDGTDNPNVILRDITEERCEQHPNEKAIFLCKIHDSTMCGRCVHSGHRPCGEEVVDLLNEVVNIDCERVNTMKSLLMEIKDEILLLKNEAEHSKENYKKNADKCVQECMGFENKIKQRVHELTSGIRDGITKKHNENLTIHSHITKLCDEKTKWCRDLESKIDSFVDKNMAGHLYLMNRHFEKEVSDARFHLKEFKQNILSKENKVILKCVFEDLEEVCEHQEEVTGSDDGNANDVGASTTKINQTRRELTVLLSQIKQDLDQSEKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EYS0</accession>
    <name>A0ABY7EYS0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="94" mass="10877" checksum="AEB157B935DD228E" modified="2025-10-08" version="1">MPKTEGPGSVHRLRHAKDVWSRVRSPATSCQRRKVPGPFTGYVMPKAVDPGSIHRLCHVKDDRVIDNSDQNDNDNRNVYFDFVFFYVKLDFVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZN4</accession>
    <name>A0ABY7EZN4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="12807" checksum="BF25BCED7A3D85DD" modified="2025-10-08" version="1">MRTRDDKDTHSKAEKNANRLSSSSSSSTDSESAYLIVTDRKNPPSEIGAHSLSMQHPKMDKELTHQQSKIKGGRKIGPSKTDTKTDVKTRYPIDLYENVDYPAVKNDKRAGATTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F109</accession>
    <name>A0ABY7F109_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF10">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR14438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="199" mass="20894" checksum="74281226333CB148" modified="2025-10-08" version="1">MSGGVHVGGVKYQFLRVEDDKLVLAKKKDQGALSIQVSKTAIVIGHLPEGGQQGNLNKGIDLTMSWDSYIDNVIAQSGTGNCDKACIIGLDGGTAWTTSANANNLEMSPTEAAKIAAAFKGKDFSAFQANGVHVGGTKYQFLRAEDDKLVLAKKKDHGALSIQASKTAIVVGHLPEGGQHGNLNKGVAVIADYLESLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1X5</accession>
    <name>A0ABY7F1X5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CCKAR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_005166</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF76">
        <property type="entry name" value="NEUROPEPTIDE SIFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="23"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR15061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="735" mass="82936" checksum="F70944DC72DDA041" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F298</accession>
    <name>A0ABY7F298_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="180" mass="20504" checksum="3637B0540F37DBDC" modified="2025-10-08" version="1" fragment="single">IMDMRDDELKLIADHMGHSVAIHTEVYRMQTSVLERTKVARALLALEDGKLQGFNGRNLSSVSLDELPEPEPEPEPEPYEAGSFEELSEPDNSYEDVPEVETEAVQKPHACTGSKKRWSKEEESALREAFDIQIKMQKNVSTMEIRKAQKCYPVLQGRSEAVIRTKINNIKLGKYKKIMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4H9</accession>
    <name>A0ABY7F4H9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046094093" evidence="1">
        <location>
            <begin position="25"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="88" mass="9828" checksum="A96E3C0D24C3749E" modified="2025-10-08" version="1">MQIKAQHVLLKTVLFGVLFGFYLCGDDHNQQTEETNSGSVIGGAVGAEYEIPDSEPRSELTIEGEDNRVYYNDERAYYKNVGGNVHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8D4</accession>
    <name>A0ABY7F8D4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_031537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047351762" description="protein-tyrosine-phosphatase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="622"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="531"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR16943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="819" mass="92422" checksum="8CE31F2BCB42A59A" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8H8</accession>
    <name>A0ABY7F8H8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Farnesoic acid O-methyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_031905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022041">
        <property type="entry name" value="Methyltransf_FA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12248">
        <property type="entry name" value="Methyltransf_FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Farnesoic acid O-methyl transferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR17311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="111" mass="12357" checksum="5360391BE6D0B3EA" modified="2025-10-08" version="1" fragment="single">KYDAHILLQNGPEDYVNDVYEVVIGAYNNTRSQLRLVESVSIPHMTTTDRQGKPRSQKDEDERSYIVIGFATSTGCLGAMLLLTLLSVCLLWKKRKASGIGICSNLNLLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8P2</accession>
    <name>A0ABY7F8P2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TRPM8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_031965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF12">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="7">
        <location>
            <begin position="90"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="324"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR17371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="649" mass="75869" checksum="2B561AC6B59B18EE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDV0</accession>
    <name>A0ABY7FDV0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_001182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045661971" evidence="2">
        <location>
            <begin position="25"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="477" mass="53619" checksum="A3DB847E591D786B" modified="2025-10-08" version="1" fragment="single">MKSNMNSKVILCIVLLLLSKYVQGGNIKRKVKFLPLVSTAVDVADSIYQIAMPNDQADAVTPEQLEEAKNEILKVFSEKLAVVQAQLYGTIKETMLLANIDEINYKIQSVLLDLENYLLEKGNEQKKLEFERQAALFITDIRSLPSRLEKSFANADVSLLELMASNSKCNMSGINEFRDMYLNLTETGIIIELTYKKLQDSSIETGSEWWDSQVRQMIDSFEKGDTACKNKFIEMLRTNMVTIDNVTELSTLVHQNYVWYIIDIFILEQKQPEEKIFIDGTTSNMMALLVNGLRKYAIYIDRQTRSNDIKCLLLKTYTQTPLDNIFVLDAETPVPGYISTIDGEFKKTSFYYGENGLSESCHPDIVPDIEVLDTPESEESKDGLTVGQIAGIVTGSVLVVIIIIIVIIIIIIIIIIIIIIIIIIIIIIIIITTTTTTTTTTTTIIIIIIIIITTTTTTTTTTPITTTYTTTTILRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEH8</accession>
    <name>A0ABY7FEH8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="181" mass="20947" checksum="235D7C20EE017456" modified="2025-10-08" version="1">MDLATIHQDRLNIDHLATIHWGRLNIDHLATIHQLNIDLLATLHRDRLNIDLLATLHQGRLNIDHLATIHRDRLNIDHLPTIHQGRLNIDLLATIHQKRLNIDLLATIHQDRLNMDLATIHQDRLNIDLLATLHQGKLNIDLATLHRDRLNIDLATLHQDRLNIDFLATIHQDRLNIDLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FF46</accession>
    <name>A0ABY7FF46_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TRH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_001209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF26">
        <property type="entry name" value="PROTEIN TRACHEALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23171">
        <property type="entry name" value="bHLH_HIF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR19371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="709" mass="78216" checksum="642147A31A8DE526" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FL49</accession>
    <name>A0ABY7FL49_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LRP4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_016281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF41">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="887"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="1">
        <location>
            <begin position="54"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="487"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="1">
        <location>
            <begin position="554"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="780"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="834"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="834"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR22307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1050" mass="114799" checksum="9F1F47698ED3900C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLM0</accession>
    <name>A0ABY7FLM0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR23032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="59" mass="6800" checksum="9A65D3138165913C" modified="2025-10-08" version="1">MEKHEELASVTTYYENDIQLTKALELSMTLLLREKHSRTLPVQLFARVELGEMFTASSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FM20</accession>
    <name>A0ABY7FM20_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AP1M1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_036851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd09258">
        <property type="entry name" value="AP-1_Mu1A_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="171"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR23182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="426" mass="48852" checksum="8205692A3702B6CA" modified="2025-10-08" version="1">MATFILASALYLLDMKGKVLICRNYRGDIDMSVIDKFMPLVMDNEDDGLASPIIMHGDIAFIYIKYNNLYLVTTTKKNANVALVFSFLHKLVQIFLEYFKELEEESIRDNFVLIYELLDEVMDFGFPQTTDSKILQEYITVDGHKLEIAPRPPMAVTNAVSWRNDGLKYRKNEVFLDVIESVNLLVSATGSVLRSEIVGAIKMRVYLSGMPELRLGLNDKVLFETTGRGKSKSVDLEDVKFHQCVRLSRFENDRTISFVPPDGEFELMSYRLNTHVKPLIWVESVIERHAHSRVEYMIKAKSQFKRRSTANNVEIVIPVPLDADSPKFKTTVGSCKYAPEQSAVIWTIKSFPGGKEYMMRAHFSLPSVENEDQEGRPPISIKFEIPYFTVSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQLRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FM66</accession>
    <name>A0ABY7FM66_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037693">
        <property type="entry name" value="CCDC15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14817">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14817:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="475" mass="54468" checksum="7D2FDE35C3DCF83C" modified="2025-10-08" version="1">MASKGKRENLALRKIAKPVISTDVMGNRNVEVRAVGAWVQVESPYTEAEGVVSDILLMHCTSSFSKIRKPRMILQSFLVMAGGCCGGGEKIASVAAGEAGETSPLSGRSEKEGERTGQDEETEPAGDKLPSCRGYFYSEQERRVVGQSAFSFPDSTKKDTSLVRPHTALAVSKSVRHKESSDRPKSGYDHEAFSDQTNQVHEHVRQAKKSLVSRQVITENYVKDDLPGGMWKISRTRDDLNPAKNPSSRYTVDGEEFDILDEDLIEKVKVVNNKVYQESQDGQSGSPEDSDKENEVVSRSVQFHDDHTDHRGQRNSDYHTDHRGQKNSDYHTDHRGQRNRRQETVNRVPNIYEGVKSEEEKRRSRAQQAMYRRLFMDKEREQVKENLRRQEHRKRIVRLKKEAEAERQEEERVSQALVEPRNPVTGETSTEVLDREQQEREFIRRTIREHERRQQKSKETERLGNIVQIGKLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNJ2</accession>
    <name>A0ABY7FNJ2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">MAR_016403</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">MELC-2E11</strain>
            <tissue evidence="24">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RLR subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.30">
        <property type="entry name" value="RIG-I-like receptor, C-terminal regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031964">
        <property type="entry name" value="CARD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041204">
        <property type="entry name" value="RIG-I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038557">
        <property type="entry name" value="RLR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021673">
        <property type="entry name" value="RLR_CTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051363">
        <property type="entry name" value="RLR_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074:SF16">
        <property type="entry name" value="ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074">
        <property type="entry name" value="HELICASE WITH DEATH DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16739">
        <property type="entry name" value="CARD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18119">
        <property type="entry name" value="RIG-I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11648">
        <property type="entry name" value="RIG-I_C-RD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51789">
        <property type="entry name" value="RLR_CTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0347">Helicase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="21">
        <location>
            <begin position="759"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="22">
        <location>
            <begin position="1088"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="RLR CTR" evidence="23">
        <location>
            <begin position="1275"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="1251"/>
            <end position="1279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="WAR22429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1413" mass="161791" checksum="E2B3D0E028502B53" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRF4</accession>
    <name>A0ABY7FRF4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CSH1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_038482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="537" mass="63540" checksum="69833EF17AF09A1F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSK8</accession>
    <name>A0ABY7FSK8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="101" mass="11431" checksum="86636D4931EB75C0" modified="2025-10-08" version="1" fragment="single">MACTVYTRELCVENLQSTFRRTGIYPLDGESPKPGPSHTSSYGYDTDEMTVENCFFCGCFQTKEQTSCVSLTFVKVDRCDGIVIGRPCNHWTHLKYCTPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSR4</accession>
    <name>A0ABY7FSR4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR23766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="60" mass="6554" checksum="C7697F6A734581E2" modified="2025-10-08" version="1">MIANPEGATLTAKPYSNEFSADHVTSVFRKVSIYPLNIETVTETKTALPTINAFEAAEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTM6</accession>
    <name>A0ABY7FTM6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_011054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR25350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="99" mass="10719" checksum="D07715DA159B1CDC" modified="2025-10-08" version="1">MHIQVEERVFSSFAGSSGCLGSALVAEVYALAYWRMPGYAPVSYDLCGCMGRFDNGAPVGREGSVVEMAHVPKPVYAVCDDVHRLLQHESPSCHTDGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FU16</accession>
    <name>A0ABY7FU16_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="512" mass="59140" checksum="52D3CE9FD6641B54" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWB3</accession>
    <name>A0ABY7FWB3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR25174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="48" mass="5287" checksum="FC9915D2037F3ED4" modified="2025-10-08" version="1">METETPCVTHADSTTNYTTCDICAFLLNDANPWAPAMVGEPISAWYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWQ9</accession>
    <name>A0ABY7FWQ9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="733" mass="82193" checksum="70C1DD6EB0D83F29" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXN7</accession>
    <name>A0ABY7FXN7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUSTY-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_012651</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051302">
        <property type="entry name" value="Dual_SerThr-Tyr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46392">
        <property type="entry name" value="DUAL SERINE/THREONINE AND TYROSINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46392:SF1">
        <property type="entry name" value="DUAL SERINE_THREONINE AND TYROSINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="101"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="274"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR26947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="308" mass="35033" checksum="D590A9DC62F00E45" modified="2025-10-08" version="1">MPWSQSPRIDDDWKKKVAAEMLASLSATRLAKSISSQIKDRLNKSHDAFLTALKQLEMKHSGRLTKIEEERLKLRKVHAPRVAKVALESTSLKDVILYGMPQMGREIGRGQYGVVYSCDSWASYTPCAIKSVVPPDEKHWNDLALEFFYTKNIPDHDRVVMLRGSVIDYSYGSGTPAVLLIMDRLQRDLYSAIKQNLDWVSRLQLDKDNRGKITDLGFCKPEAMMSGSIVGLRPEHLPVFDDECWDLMSNSWECEPAKRPLLGEVHATLQGIYDRYRNKPGGPTKTAKESPPKPLTQKNVKYKLKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3D4</accession>
    <name>A0ABY7G3D4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UAP56-interacting factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07078">
        <property type="entry name" value="FYTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="26602" checksum="65AB0D1FFAD3EC14" modified="2025-10-08" version="1">MASVKMEVDKVDMSLDDIIKLNRKEQRANRGQGRGGGARGRGRGRPGTGRGAGGQPQSGRGFSRGGYRGRGASRGRGSSRGATRGGANIRGRGPNRYQQLQLSSPVQKLKLQQQTAKQITRGRSRGLGTRGGFRGRGNLRGQVVTRGRGGARGRGVRGAKSGIRGTPRGGRGRGRGRGRGQGRVLTRVITNSALTGGAQGGKRRRWRVPNTQTDDSGILTTTSLNERFSESPAGSQQANPSTDTLGRKVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4H0</accession>
    <name>A0ABY7G4H0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="71" mass="7909" checksum="9FCB9A6E821A64AC" modified="2025-10-08" version="1">MTSLAAGSSLLDTFSDLFGLTSLVASAARRFQRLITNQQLVDRYRFNRAGLNYLETVFGPALEPATMRHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5B6</accession>
    <name>A0ABY7G5B6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">UNC8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_014216</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR28512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="363" mass="41002" checksum="6AE0E9DBBE908CBB" modified="2025-10-08" version="1">MGKTAVSEYMDYSTVHGMGRLKNTPFKNLYDYNYTEFDKTDISSSFDNDILFDSAEMFKTRMALLDYETLFNYSQPMKEFMLICNFAGSKCTEYSFLHAIRSYDYGICYVFDPSYQLCQDPDSESGCGYVASAGQQYGLELLLNVDQAETVPFVTSSSGVLIIPSDRFNDYIDVNKGVFVPTGFEASVALRKKSTLRVPGMDVDRKRCDDTATISYEECIRDSQEQHILETCGCVQHFYKSGYLNASLSPENTVDPDTGNIPCYTEEHQKDNLLLVRVFLESLSYENVKEEYSYGIVNFVSDIGGQLGLWAGFSVLSVLEVIELILLLFAMRKREAQTAARDATSMTQVQPVKDTDISLRDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5F9</accession>
    <name>A0ABY7G5F9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="96" mass="10706" checksum="E7414A4D0203D258" modified="2025-10-08" version="1" fragment="single">PACLEFDLSRHASSDVNYTYNTVSTVDESACFLECFDTSYCRTFRFSSGTCYIYTCGSDCVTSYLIPGSFDIYHRTCYGPAKEVTRGAESRPVVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5N6</accession>
    <name>A0ABY7G5N6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="388" mass="42657" checksum="085ABBE04EA63F86" modified="2025-10-08" version="1">MAKPTARLDIPWSTGNSYKTAMTTRRFERPYSTDNPYRTVPTRGRFERPQSTDNPNRTAPTTDRIDRPWSPGNTYRTAHIKGKCSVSKLPKITVESIDGKWSTADNRRLWVLKQLERLGKISSTNVYIGGISSRKKTTNNGGVSIRFKENRSPGGLWHLKPDKLIPSTPEAQEGHSFSENDQNQRLEKDTAPLANPSLDSLAEEGQTIQCSERSDSNQADASEHSTNGDGSGCKVILPNLSDANSIVGNQSTPSPTGLESEYSRPEVALSDSDQEEGNVLSEKELFQDMSSSITDDIDRTTNGKDGIAVEQPPDESQFVKDASLKIRTRSRNHNKSPYEREAGLSTKYVRALSPEPPTAATGGILTVPEIKPEHTEPITYTGPALSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G630</accession>
    <name>A0ABY7G630_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="369" mass="43159" checksum="0677C3048A7E6F5E" modified="2025-10-08" version="1">MASRRKQSYIYDDDTDEVDFDFYCSDTEQKCQAKLNNDCENLIISQRPEQNELQIKINNELKDEEIAENVMEIREPYTPSDIKVIPLDGEEVAVIKIIRVLRNPFQVKKRKIKTPLQLRVADIVAFRYYGLEHVAIISDITDVNEGSRSARVKCIHYGLRHLFAKREIVDEDFEMNLAVSSWHVYDVNGPHTYSRDERLSRARKRVGEKRWKITNRSDFLCHWATIKTTNEDDIFSEVHTDEKLPAGKKAITNTRNDNEENMPVDLLNTTPVCIAEELRLGDVVTFKNEKGILVKKKTTDDQQKEVLIYLIIPEYPIVKRIKYTVDLNTNDIYVLHYHPARCIPMQERVKRALFLEKKNVCPFMPVMHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7Z7</accession>
    <name>A0ABY7G7Z7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Short-chain collagen C4-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF18">
        <property type="entry name" value="SHORT-CHAIN COLLAGEN C4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="45888" checksum="CFBA34067D716338" modified="2025-10-08" version="1" fragment="single">YTAGNSYDQGGAAEYLCLTSEPIWDVYDHSSQDYSAKFESADYEDKNGKLMYLVESICGSLRCPPYVNYRAVYVRWGRTTCPANGTDLVYTGYTAGNLYSQNGAADYLCLTSEPIWGVYDDTLHTYSARIYGTEYEFGGEGYSDGGAQFFGKNIQNHDAPCAVCITSRRATVMIPGRNQCYPGWTKEYSGYLVSGLSGTQGHASSSNYACLDAEAEYENSDIEDKNGKLMYLVEAVCGSLPCPPYVNYRYTAGNSYNQGGAAEYLCRTSEPIWSVYDDTAQRYSSKVYGTEYEFELYTNGGAQFFGKNLFNHDAPCAVCHTSRRTTIMIPGRNQCYPGWTKEYSGYLVSTLSGYSGYSSPSNYACLDSDAEFESADYEDKDGKLMYLVESICGSLRCPPYVNYRELTCVVCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G995</accession>
    <name>A0ABY7G995_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helix-hairpin-helix DNA-binding motif class 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.280">
        <property type="entry name" value="AF1531-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.320">
        <property type="entry name" value="Photosystem II 12 kDa extrinsic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051675">
        <property type="entry name" value="Endo/Exo/Phosphatase_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180">
        <property type="entry name" value="ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180:SF32">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12836">
        <property type="entry name" value="HHH_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="2">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR30019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="675" mass="76320" checksum="B2CB40FD009EC75F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GA98</accession>
    <name>A0ABY7GA98_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ENDOV-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_033021</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2170.10">
        <property type="entry name" value="archaeoglobus fulgidus dsm 4304 superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="ENDONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511:SF1">
        <property type="entry name" value="ENDONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR30479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="233" mass="26536" checksum="658A9A059C601FD6" modified="2025-10-08" version="1">MCLFRRLSELFYRYVLDPLGFYVPRLSRAEKLLPEEIRLKWEREQEALKERLVLEDTEDLKVMATLGPEDTDLIKQFYIAGVDISFIKGDDVNACAALVILSYPQLEVAYNDCQMVKLTAPYIPGFLGFREVPMIQKLFDQLKRERPDLVPHCVMFGSACHLGVSLGLPCIGVAKKLFHVDGLEKDASHKEKNPIYISQGHLVSMDTSVRLVQHCCRHRVPEPVRLGSYAGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAL0</accession>
    <name>A0ABY7GAL0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF985 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387:SF3">
        <property type="entry name" value="DUF985 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="RMLC-LIKE JELLY ROLL FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF985" evidence="1">
        <location>
            <begin position="17"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="174" mass="19653" checksum="414CB2A218A311E8" modified="2025-10-08" version="1">MTTDGEGVAMEIERIKKQLDLGPHPSGYGAFREMFKGDRQVIFTAKTSHSGSRSTGTSIYFLLQRPNSVQWHKHLSDEGFYWHAGGKVIIHLLSDSGELTTTTLGDVTRNEDCACQAVVPHDTWYSAELAPDAQYSLYSAVVIPGFEYEDWIQGKREEMVKQFPQHEELITRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBJ9</accession>
    <name>A0ABY7GBJ9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SC5A9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_034027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819:SF195">
        <property type="entry name" value="SODIUM_GLUCOSE COTRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00457">
        <property type="entry name" value="NA_SOLUT_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR31485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="611" mass="67509" checksum="2E55DF627934C0FC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GDF4</accession>
    <name>A0ABY7GDF4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_033533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046211644" evidence="2">
        <location>
            <begin position="33"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR30991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="475" mass="52161" checksum="61E93DCFACC24D00" modified="2025-10-08" version="1">MCTKANPKRRTCWIRTFWTLVALSTIFAKCEGFCFEGKLVPEMTVSKRVRFFCEVKTLEGSVVRLLPGSHIYMADQCMDCVCDSSGLHCCGHCEAIHDGCHTMIVNRNDHTKDCANQTVDFAKLEKDLPHPDNVYGIKGGRRRAPSKIPAVLMAQDSGASPPVSPTLNTILKKHLRSILPKTFFKIKEAADNVSTQGRSQAQNKTTTDIPTTSPTTTTTKSSTTILSTTTTTTPPPTTTSTTKAPTTAQTTTASTTTEPSTTTSPPTTTSTTTAPTTTITTTSTTITPTTTPPPPPTTTTTSTSTTTIPPYIGKHPPPVQELSPTKIISDRRNTRGHMPAILNRLPISRPTVHRQIQQQHLQPPTPPQHLTHADQAAYDNIMEHILSRMREDTSSPVVMTTPSSIHVPRSFSMQNFLPQTKRPSDSIMMVRKMFADIHSDSSNSGSSFYTPTTQPPMFFNDPLWGSDNFLPMLFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GI32</accession>
    <name>A0ABY7GI32_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_033348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056564">
        <property type="entry name" value="Ig-like_KY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053041">
        <property type="entry name" value="Transglut-like_Superfamily_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020:SF1">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23265">
        <property type="entry name" value="Ig-like_KY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="2">
        <location>
            <begin position="152"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR30806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="697" mass="79906" checksum="4AA40D5BCD45FA2C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D760</accession>
    <name>A0ABY7D760_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">INSI2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_005982</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the INSIG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025929">
        <property type="entry name" value="INSIG_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301">
        <property type="entry name" value="INSULIN-INDUCED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301:SF3">
        <property type="entry name" value="PROTEIN NSG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07281">
        <property type="entry name" value="INSIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAQ93511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="200" mass="22734" checksum="572657BD69DC9E4F" modified="2025-10-08" version="1">MLVKMQILKRGVILFMFGMFFSLVLNLLQTYREIREDETPPGLFDHYSSCWWVLPVCGLTAAFVGLMYPVLDSHLEEPLNVKSEWSNVMRCVAVFVGINHASAKLDFMNNLHMSLTLAAMCIGLWWLFDRSKSGFGLGVGIAVLATILTQFLVYQGIYKYGKADFMFMRSWLPCIFFSGGITIGNIGRQLALYDDKEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DC21</accession>
    <name>A0ABY7DC21_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="21">ABCB6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MAR_007057</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">MELC-2E11</strain>
            <tissue evidence="21">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endosome membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032410">
        <property type="entry name" value="ABCB6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF654">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16185">
        <property type="entry name" value="MTABC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="10 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="20">
        <location>
            <begin position="311"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="19">
        <location>
            <begin position="405"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="WAQ94586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="641" mass="72707" checksum="0963B90F20BCD746" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDL9</accession>
    <name>A0ABY7DDL9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026337">
        <property type="entry name" value="AKG_HExxH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04267">
        <property type="entry name" value="mod_HExxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047509384" evidence="1">
        <location>
            <begin position="21"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="498" mass="57013" checksum="932BF7E4DEAEBA74" modified="2025-10-08" version="1">MRGSKHSHAVVLFCITLAFADSSNQNFIQNLQRNVGEYGTSHFSWNIQNLDHANYQSLRAIEDDNDREFRAFLLNHSPKVKNLLAREHVTMERNITNGEHEDKTHKTHQRKLRKRDAALPQRMAILIAKAQPRKIIRSLQKREADNTTQMMIYNIDPWFSIADLMSLRFPKKYDDYFNSWSQSIVLFGNSEIHREEFKHNFNRLPLQIMLELLSLTDKFQHIFWPFNFDQAFMNQRLALLGMSGLSINGHKQKERFYAELEKHQTIKVPVEEERVVLSFDHPDLVEGLNRSGLLEMSKEYVEAGNHLYTLKEQEHITSKVQAAMDLINSTNPELYRAIHQVIGCIAFYKAEQPESVGGTISSALGVIWQDPSVYPDHSVANYAEQIVHEFIHSSLFLADMVHGTYIDRSLLTKSKVYSPVRKELRDFDKTFHASYVTTGVTIFQSRAGNVGDAQTYAGTLRAAVDGLIAIQNKAGVLNASGAAMLQAMDDVLTLIRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGW2</accession>
    <name>A0ABY7DGW2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FXL15-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_029582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd22126">
        <property type="entry name" value="F-box_FBXL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF261">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="2">
        <location>
            <begin position="179"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ96892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="308" mass="35018" checksum="0F9D34D84D70A445" modified="2025-10-08" version="1" fragment="single">MACEQSGDYGQHITVREEQALTTNSGDSSFVVRLYDLPWEDIVFQYIFPLLPIQTLFQLRRVSRECKHMVQHYFSISRVLNIARIGGKVTAEAFHILTDESSNLLHLNLRNAKDWLNDTLLMPVLKSNARIQTLDLTNCISLSNTSLQVLATHCVELKCLTLRDCVWLSPEGVTVIGLYCKELEKIDISGCWNVNDEALTVLVKGCSKLTFIQMSKIYGITDSSMSVLCRSCPNLVHLNVQGCWRITDDSIRFLTEYGKNMQMLQIRECNQVTETVLSKLRSNGVKMDRLAPPSMEGHNQRITKAHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHW5</accession>
    <name>A0ABY7DHW5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neurotrypsin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Serine protease 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MAR_029964</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">MELC-2E11</strain>
            <tissue evidence="21">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00108">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00018">
        <property type="entry name" value="KRINGLE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0420">Kringle</keyword>
    <keyword evidence="4 15" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046604912" description="Neurotrypsin" evidence="16">
        <location>
            <begin position="20"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="47"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="17">
        <location>
            <begin position="303"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="20">
        <location>
            <begin position="397"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="525"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="633"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="753"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="18">
        <location>
            <begin position="904"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="823"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="WAQ97274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1143" mass="126441" checksum="1DEEC16E7D381F2A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJC4</accession>
    <name>A0ABY7DJC4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="263" mass="29219" checksum="3FF41B4B665C3CFD" modified="2025-10-08" version="1">MRMICRLLLTGNVFIFLGLCLALAGFCGPAWFRTSYPPGPEPTWTLEEGIWLARFCRHITGECIFTVREPLDEPHWLEFKVLSVASPLSGITDMMITAVTLTKVNKSEMAPKHLLLISISMLFVPVFKVTHVTTKFSHFGKAADCWSFVLASTGAACMFAASAAVGLALAKAAFKLCDQKNKSRESHRRRDEQLRRNEIIARYFHGENRAYGSPFDEDSIVNNELRVSTDTDSAYSVISNGGLNDRNTGHALHLPMSSEITTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DL61</accession>
    <name>A0ABY7DL61_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SVEP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_029765</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050350">
        <property type="entry name" value="Compl-Cell_Adhes-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325">
        <property type="entry name" value="COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325:SF575">
        <property type="entry name" value="LOCOMOTION-RELATED PROTEIN HIKARU GENKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 8" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="C-type lectin" evidence="11">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="9">
        <location>
            <begin position="128"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="9">
        <location>
            <begin position="313"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="428"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="498"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="556"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="620"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="748"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="12">
        <location>
            <begin position="808"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="12">
        <location>
            <begin position="1055"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1853"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1866"/>
            <end position="1883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAQ97075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1920" mass="207401" checksum="5F97F02F62980C39" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DM84</accession>
    <name>A0ABY7DM84_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AK1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_028800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd04515">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ96110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="248" mass="28473" checksum="8A062F08D8869F24" modified="2025-10-08" version="1">MIQAQNRTWVSEDGRFCYFSCKPKHKGRKYMVFKGVALRRGSLESPENVIVKVYRHTHGGTGDWGLYKTLGQLARQVADAFNTYLNIIQVEPKVEFLAPEMAIMDTQSDFLIIARFFWNFRKKFSEDEALVIERRLKDDFMTFITKDGHAKHELSALPAAFCHYSYTESGGQYVICNLQGVIEKGKFVFTNPVLHSNRETFGESDKGAKGIATFFENQVCTYLCQDFIKPTSLDKKRPPSYSEVCPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMX9</accession>
    <name>A0ABY7DMX9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IgGFc-binding protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035234">
        <property type="entry name" value="IgGFc-bd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17517">
        <property type="entry name" value="IgGFc_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IgGFc-binding protein N-terminal" evidence="1">
        <location>
            <begin position="120"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1142" mass="122946" checksum="942B6101791B0507" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DN56</accession>
    <name>A0ABY7DN56_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WIPI4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_030188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ97498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="427" mass="46605" checksum="E11109F96280D960" modified="2025-10-08" version="1">MSTKNSMVNECYILEVCLADLVPQSTHIQCGDCFILRRFKLGHGAVAVHQFVCHRVVHTVEPVLNVLYGVVRASLSNMSLGAIAFPRAPDGFTPSFIAILAITSVFLNLILAPGHHLNTVNENKTGAAALTPTADPVFVVLIAIQATGVDMTRKGVISLRFNQDQGCFTCASEFGLRIYNVDPLVQKLCLNTEKVGSVYGAEMLFRTNIVALIGGGNVPRFDEKAVVIWDQSRGDATNSVVLDITFAQPVMAVRIKKDRLIAVLRNQVHVFTFPNNPQKIQTFETRDNPKGLCEVSPYGSNLVFPGHVCGSVQIVGTLIRVFDANKKSQLLELRRGADPAKLYCISFSLDSAYLCASSDKGTVHIFAWGLANFTVPAECACVCAFAPNHAVIAVCVDGTFHKYVFTKQGNCNREAYDIWLDIGDDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNK0</accession>
    <name>A0ABY7DNK0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_022826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF1">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ98453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="145" mass="16382" checksum="133021E52D0D1674" modified="2025-10-08" version="1">MNHVFTPHGLFVKDLATTYNVDPIITFDQPLWYKTQLIIAPQPQSSPMSQIVCRLSALHIQMSFLGTIGKVMNDSGVVRDCSLLEMLPFFAATGHNAYAKSTYIYLNRDLSTTYPQVYKNFMEGIYGVQHSDRNWAGLSTDVIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPM3</accession>
    <name>A0ABY7DPM3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">NEIL3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MAR_023727</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF10">
        <property type="entry name" value="ENDONUCLEASE 8-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG-type" evidence="15">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="14">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="16">
        <location>
            <begin position="334"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="16">
        <location>
            <begin position="378"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAQ99354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="422" mass="47404" checksum="BB2E52D0C00F2B25" modified="2025-10-08" version="1">MVEGPGCKLKGIKIKAKIKGQCVKRVGGNAVDKVDNDSGGRTETATLELHMSEDVLTFKKSSVDIRPSVPCRQKYETMNDVDICSPVFNFRRAFSLVREQTDRQVCDVLLDQSILPGVGNIIKNEALFDSGIKPSSKCRRDGKQLSPYYKIYGKRLCKQCEGRVIICRLGDDSGRVTYFCENCQTNDLVNKNRKLPSKNSLLGWVQTGSHISQPEIADWSCEHCTLINKDTATSCSACLNPRVDKTVEAKPAQFGAKGHVSGQGNQTMNRKRKTEDSGVEQTRAKTQKINTSVVKLENKTGFKTKIPQNGSAKTNKTQNGTTKEQSDKSRIPMCEHHKRKCSMKEVRKEGQNLGRWFFSCVVRSCNFFQWADVNFPTCTDHGKPCTIRTVLKIGPNNGKRFFTCKLPKKKQCKFFEWAIGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPT0</accession>
    <name>A0ABY7DPT0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="121" mass="13763" checksum="5B1C6C9320E10105" modified="2025-10-08" version="1">MSLKQNCSLFATLYVSCQVREGNLDEIFEHENSNFPPALSNLRLCTNSDLLECLENPNVQVLVIDGAVFVNILTPTVLHKGKEIDERRRVLSDSRVPENLQAYLRLEENKTDLLIKQIVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSG1</accession>
    <name>A0ABY7DSG1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF46">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="518" mass="58649" checksum="48482102817F39CB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTR2</accession>
    <name>A0ABY7DTR2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_024440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ARPC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR00068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="134" mass="14848" checksum="087E803BA44E014F" modified="2025-10-08" version="1" fragment="single">MSKTVASTKFRKVNVDEYDPEKFADDTPDGEEQGPNEAEVNNCLAQYPFPGKHVDALNVILKNAPVGAKNESVKDRAVQLAIRVLTTFKAADIDQAVKGLDSRSLDILMKYIYRGFEFPSDGSPCASLLTWHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DU02</accession>
    <name>A0ABY7DU02_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">JIP4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039911">
        <property type="entry name" value="JIP3/JIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13886:SF4">
        <property type="entry name" value="JNK-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13886">
        <property type="entry name" value="JNK/SAPK-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="632" mass="68552" checksum="581325EC5FEC2866" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUW1</accession>
    <name>A0ABY7DUW1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RA51D-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_007788</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd19489">
        <property type="entry name" value="Rad51D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051988">
        <property type="entry name" value="HRR_RAD51_Paralog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047323">
        <property type="entry name" value="Rad51D_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048943">
        <property type="entry name" value="RAD51D_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21794">
        <property type="entry name" value="RAD51D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAD51D N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Rad51-like C-terminal" evidence="10">
        <location>
            <begin position="81"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR01230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="299" mass="32359" checksum="E957D7FD08C06B25" modified="2025-10-08" version="1">MSVLRLGMCTALDQDNLDKLKLKNINKATDFISKDPEEIAELCSIPYKDAVAIRKILLAQYSAVPINGKQLYTRVVESSCILSTGCERLDAILDGGLYTGEVTEVCGGVAAGKTQEDQTAVCIDTNCSFSARRLEQMMADDVDKDNALFRVHAYDAFTYHEVLEVLETLKSDLKKGDDPFCTSLRLLVVDNVASVIYPSLGGGFFADNQGGITRLGLTLKSIASEFSIAVLISNNNVTGEGGAKVASLGRQWSQIPHVRFMLDGGEETQDERSASVIKNTRGAIGACTKFSITENGPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVQ6</accession>
    <name>A0ABY7DVQ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34305">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34305:SF1">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="258" mass="30131" checksum="100B427C7B7B5498" modified="2025-10-08" version="1" fragment="single">MYEMRSFAPEIRDLIAESILCPEDATFQFGTYNPEKLGRAYYFNEHGVKLRNVRKFQIDEDRAGRNNDHDDEAMDFERCRKIYSKIQQSAPGTSNLFLWFCPDHGHCYGFHMTVAEGRKDPSASLYSHLAKPPQAVFYDFACNLQEYCLNRESGYYKNVRFFHDIFHGYSHKCSTSFRSSRLQGFESVNSEICEQFNSFIQILKKSARQMTQSHFCFYLQFFIHDLSEQTPTLASSFAVEKGQQVPPEVPPEIHHVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DW96</accession>
    <name>A0ABY7DW96_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_023588</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAQ99215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="429" mass="50303" checksum="996B5681F4CA9EA3" modified="2025-10-08" version="1">MQHREVPLAPVLVGVDEDTATSNSYVEKVVKQRLQKVREFCAKNIKVNIWENLRPTGQVWSSMKHDIHYCLTPKIGCTYWKRVMRFIAGDYNTNLSISKPRDIDRKYVHYGNMKYIRHVDLQSTMVRGEMSKGRSFMFTREPYGRLWSAYIDKFLLPDFWRTDAQAVINKVRRNATDEQRLCANDVTFAEFLQYIVASYPRKLNEHWQPVYKICDPCLVVYDVIGKQETFANDSNYILQKFGLGYLIPTPVTNLPLGTTQESGYKRTFKETSRQGEDEDTATGSSYVEKVVKQRLQKVRDFCAKNINVDNWENLKPTGEVWSSMKHDIHYCVTPKIGCTYWKQVMRFIAGDYNTNLSISKPRDIDRNYVHFESLKYIRHGGLESAMTRGEMSKGHSFMFTREPYSRLWSAYVDKFLLPDFWRFKIVKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZS9</accession>
    <name>A0ABY7DZS9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_008840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF9">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4 8" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="9">
        <location>
            <begin position="49"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR02282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="355" mass="41155" checksum="DF9C64D18394A6F8" modified="2025-10-08" version="1">MAEMFDLKRCPEAFNLKVGESADLSPNKDKGIVKKMLTQGKGGEYPNEGDKVFYKYTAYLGDKMIKEYIFDSTEKDGKPFEYECLKGKVIRGFELAVLTMKPGERSLIFIKPEYGFGKSVPPSVPLDTDILFDIEIIKRYLKHWKTGEEARVFFAARQAFGQEGCEKYDIGPNKDLTFWINMKQIERVKEYWEMDYKEKMDKSVEYKEIGEKHFKGGEYELATTIYEKMLEYVQDDLEGEDEERRRDLVVFGNLRLAKAYLKVEKNSKARDCCDKALTFDENNLKAYLRRGMANFADGEYETAKKDFQKVLEIEPQNKPAKDQIDKCIIKMDEKANSDIELARKMMSSIGKQVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0L1</accession>
    <name>A0ABY7E0L1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_009080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR02522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="216" mass="25090" checksum="AD36B6BF7A62E031" modified="2025-10-08" version="1" fragment="single">MIQQSQTRGKYGLKCLCRRLCDSDMIQQSQTRGKYGFKCLCRRLCDSDMIQQSQTRGKYGFKCLCRRLCDSDMIQQSQTRGKYGLKCLCRRLCDSDMIQQSQTRGKLCDSDMIQQSQTRGKYGLKCLCRRLCDSDMIQQSQTRGKYGLKCLCRRLCDSDMIQQSQTRGKYGLKCLCRRLCDSDMIQQSQTRGKYGLKCLCRRLCDSDMIQQSQTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E164</accession>
    <name>A0ABY7E164_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_009482</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056371">
        <property type="entry name" value="DHX37-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23362">
        <property type="entry name" value="DHX37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="316"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="612"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="238"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="565"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="619"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR02924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1145" mass="128401" checksum="DD3C9FE413CB78A0" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4L8</accession>
    <name>A0ABY7E4L8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_020322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="841"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="50"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="572"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="669"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="945"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR04953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="997" mass="104237" checksum="03DEB8C1E98AE3F2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5D5</accession>
    <name>A0ABY7E5D5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_019763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33153">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33153:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="2">
        <location>
            <begin position="349"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR04394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="611" mass="70859" checksum="BEE4FFD0B75C0373" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5G8</accession>
    <name>A0ABY7E5G8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="404" mass="44708" checksum="5322B0A97801BF9E" modified="2025-10-08" version="1">MQSLGFVSKYTVKSCHLARELGHTWLSFRLAASTALMESMMVRTRGRLGEGGDRVFWMVFHSWERMFEKAALFKDTETMAHQKNPLVQVGTGVSIQCLDKPHEGLVVNWEGVETKSTEVLGGSCNVSLTVKHSDVKQWHNLSVEWTSKGNALLGVKNSTGSMLISTILVNRTMEPISVKISFRGNVIEPYIDIRVCPYTLIQTNSLGVAEIVGIVLGSLAVVVAVVVALIVLLRRKKKPSCKKPEEGTGPPLKAMDREGVTACYNLNIFGVKLQRFGEYGHGRFTLENLIPVDGHLTHMDVEWVVASLAFKRSSVREVVVPLRHTLVRDGVLRINVVTEGSSNQPKRYWPPCPSCLRQSAAQYRKRSFPRPSMLTVRPEAWAPTASCIAGNTSGRPVRPSSTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E652</accession>
    <name>A0ABY7E652_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PSMD3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_020866</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 3 N-terminal TPR repeats" evidence="4">
        <location>
            <begin position="133"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 3 C-terminal" evidence="3">
        <location>
            <begin position="325"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR05497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="394" mass="45091" checksum="6F178E9204133D9C" modified="2025-10-08" version="1">MPVTTDVEMKEASTPEKAKKDEEKKEEPPKDPELLTLEDIRDYIKNIEKSVATKEPRFMLRVSRGINSVRHRLNNNILRKLLQAYLQAQTQLPVRDELLLYLDEPMLTNGTGAQPFRPRSGKLAANPVIPEIEALVCSEKLMVKIGSQNRRTLDILAARCYFYHSRVYELKNQLEKVRNFFHSRLQTAVLRSDFDGQASLLNLLLRNYLHYNLIEQADKLVSKSTKDQSPTVGVLRGPQALATGPKKGTPACSRGIQTNTVRTGNLPRFNEVLHQFGAKFQGEDTYTLIIRLRHNVIKTGAIRDGVIEATIDHEKGYVQSKETLDVYKTREPMAAFHQRITFCLDIHNNSVKAMRFPPKSYNKDLESAEERREREQQELESAKEIADEDFDGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7H2</accession>
    <name>A0ABY7E7H2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_021302</name>
        <name evidence="5" type="ORF">MAR_021331</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045034257" description="Ig-like domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR05933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR05962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="60295" checksum="983784DF4C25C83A" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7M0</accession>
    <name>A0ABY7E7M0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan-rich sensory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33802">
        <property type="entry name" value="SI:CH211-161H7.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33802:SF1">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35714" checksum="7C099C89081CA7DF" modified="2025-10-08" version="1">MNVSNPKNNMARHSVPKIVLIIATIVVFALTAAFNGLAAAGNGGGVFNNRTGDISDAFYLEVTPAGWTFTIWGFIYAWQAAWLVYALVTICRRKVGTYVYLMPVFPSVLFFAYIFNNVSNVAWLFAWDQMKLAIALPLIALTPLTLFVCLYFSFKTLYDNPDYLIRNGAIADIWLIRLLIQNGIAFYAAWVTVATFINVALVMTYKNGDLVNTAVPQDVSSTVFLSVVLVVIVVWFSLDMSFLDKYTRYTFAPYITWTVALAGIISKNYDLDTAYRNSIISVVVQAVAATCLVVKIPVMIWRHFKRPIQPLLSDFKPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7P0</accession>
    <name>A0ABY7E7P0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="844" mass="96417" checksum="4740D0E057ED1896" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8D1</accession>
    <name>A0ABY7E8D1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="210" mass="24447" checksum="2CB47B156E53F12D" modified="2025-10-08" version="1">MMTRVQKHRQTRMVNRNNDDDLDEMNDSSSGYGTQESLPRQLIIACLEEWAKEEIKSKPKRNSGILTPRRKTALFMKSSEIKGEKAGKRLLFCNVLLHHMKSEKGDRGRNTSLYSTIAGDVIKKYKCISKLAVELDVNRNKLSEVYMNGVKFAKIRRRRVILKLQESVTKFFEREDNCRIQPEGKVQIRVLTDYLANLHQKYEAELPDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8H0</accession>
    <name>A0ABY7E8H0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="166" mass="18626" checksum="5E9A5110C684EAF8" modified="2025-10-08" version="1">MDLWTEAGTITASINHSVVIRVMTTARHVEIWILQDSQIQELGINCTMNLRHLNRNEISKSHSKCSLAIGDSRLIQTPNTAKAPKYQYDHGGTYQCDMGCKCICTWTLDHSLLTTWTDQDIPGFVRNIIVIGRRCGGLECAVLTWVHDTPMTGLVDTHLLLFTSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E943</accession>
    <name>A0ABY7E943_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ZN710-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_020846</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR05477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="264" mass="30827" checksum="396D7AEB874476D5" modified="2025-10-08" version="1" fragment="single">NKAWQEQLWKQTVANQMEVNTLNFGTEQELQEHLVKHEGKRPHQCDVKGCDKAFKTAYSLKRHQQGHQRVKYRRNVDTANLPLYECPECDETFNSISNLERHGQNEHPGIKLFKCSEEKCDQRFTFHYNKMRHILTHSENPARPHQCHRLKTSLQKHLKLHAGVRGFKCKLCDKQFSRREMMEAHVNKHAGIKQFVCGICKKRFSTQGNLTVHMNLHNGKKYLCVACGNIYNFKSNLNKHLKDCHPDQDVAMDYEPEDGTSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDH8</accession>
    <name>A0ABY7EDH8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="68854" checksum="517332F98756A97F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EES0</accession>
    <name>A0ABY7EES0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_017528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047194697" evidence="2">
        <location>
            <begin position="28"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR07570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="208" mass="22765" checksum="9CC309236AD98BD8" modified="2025-10-08" version="1">MKTQTNYIKILHLLILMLAYLAPVTAAAAVLPPDEATCTVRVNQGSVVFKISSSDPKNIISIQAKGTYVADCDQDALLRQTNDTNAFLVSLTHSGACVFIINNYDGTIFSVKIESATSTLTEVSIGGEPFTDCFSPSFVDLNLIGKERHDSNGAVKEECHANVEQEPIANNKNGKQQIDRNATAKDGQRDKIAQQPFRMSTRKTQRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHD0</accession>
    <name>A0ABY7EHD0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="345" mass="39494" checksum="E3F9CA634B550B4C" modified="2025-10-08" version="1">MDTCSLDCGERMNCCFDEMDTVKRAENEGLVCTKMMVGVNSASNRRGVYMISSCPKKNDTDCGSDHVAAWGSLAPVYSPERERVYRKSTVLNAITHPSFEYTSMENNQLDQMSPKDSFIMFLSNNEVMTSEKLSDSQKYVRSVCTTKTEHSTCRPVFCPVLQRKQPDGTCGPSVVDVVGLDYEINLNFTLTPGMEIRLFRKLCEKVDNRNKRFPANFRSPWSRYWEVKNEVYYHIEKEMVVYFVVSLTRRNRGVALHKILENTANTMRTQWIIDGDEEIIVGQEFSSYSTFSLGQSSTPGNLTFIPFALEDVLKPEETIFGGLLNNHQFSIRVLDEIRFRGKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJG0</accession>
    <name>A0ABY7EJG0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IFI44-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_035206</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFI44 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241:SF32">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="15"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR10130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="332" mass="36415" checksum="5CFBD2D2DDFE7544" modified="2025-10-08" version="1" fragment="single">MTSWQAGKQRQGDPMASKGRLSDDQKNQLEQWIGQGHKDFVLLFSFSIDGGTASAFHNKCNNQGPTVTVIHNEHKSVYGGYTSQSWTSCDDNVTDQQAFLYQLQFSGDIKCNKFPVSNHSRALIDVAGCGPIFGRGRHDLWTFNSATKIGGFYKLVGSRNGFGTDYNVSGTKATQVNNDTKSVEELEVYKVVDCSGNCARHVVPKPIEEKPWRKTTQWSQKKMLEDIASLKPVSGLGVNDFRIAMFGPVGEGKSSCVNSLLSTFAGRISQRASTGCGRTGTTTLYTPYPLKSSSGSSANIRVYDTPGFTEASGLDLIDFYHILEGHVCDHFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJL2</accession>
    <name>A0ABY7EJL2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EHMT2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_035249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041249">
        <property type="entry name" value="HEPN_DZIP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049050">
        <property type="entry name" value="nSTAND3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF14">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_25, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18738">
        <property type="entry name" value="HEPN_DZIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20720">
        <property type="entry name" value="nSTAND3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DZIP3-like HEPN" evidence="5">
        <location>
            <begin position="315"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Novel STAND NTPase 3" evidence="6">
        <location>
            <begin position="512"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1065"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1098"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR10173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1314" mass="149091" checksum="5C269173B3254841" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKF8</accession>
    <name>A0ABY7EKF8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FBCD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_034720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF394">
        <property type="entry name" value="ANGIOPOIETIN-RELATED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045543915" evidence="3">
        <location>
            <begin position="21"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="4">
        <location>
            <begin position="374"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR09644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="597" mass="67147" checksum="BCD959C83F4FBBE4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELQ7</accession>
    <name>A0ABY7ELQ7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ycf1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="21091" checksum="45A2D92D0C08B348" modified="2025-10-08" version="1" fragment="single">LNLNRQNQKKNTLIEHHKTGKNEILDEYKVLKSRRKSGVKREEALTYKEIKLMKNRLHLKDWDVLNKNSQLIIHPDVFMDITQERLLQILQDNPNHQITFFKEIIRQNQHKDKGTVDLIRNSQLTIPFEGIPDVFSDIREVEQQIQQDVANYTAYSNVNVWLDLLFFHCPNNTIYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EM82</accession>
    <name>A0ABY7EM82_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ARHGI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_036181</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd20815">
        <property type="entry name" value="C1_p190RhoGEF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13329">
        <property type="entry name" value="PH_RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041020">
        <property type="entry name" value="PH_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051632">
        <property type="entry name" value="Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944">
        <property type="entry name" value="AGAP007712-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944:SF21">
        <property type="entry name" value="CYSTS, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17838">
        <property type="entry name" value="PH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="12">
        <location>
            <begin position="268"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="776"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="988"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="345"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="484"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="680"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1237"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1409"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1543"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="602"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="698"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1242"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1268"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1430"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1455"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1553"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1582"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1650"/>
            <end position="1663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR11105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1701" mass="188707" checksum="94FACC60464AA889" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENU5</accession>
    <name>A0ABY7ENU5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPSX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_035577</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR10501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="229" mass="25881" checksum="423E09537A6680D1" modified="2025-10-08" version="1" fragment="single">MFGITQISLLAAIAFDRFVIIVKPRGFAFSKKKAIAAVIVCYINGCLWALFPAVGWGSYQLEGIRVRCAINWRSQRVADVSFTMSALILAWMVPLFVIVYSYAGIFLKLQTEQKTRFRQSLKQRSSRVKRDRKMAVTVLLMIGAFLISWTPYSVVTLIVTFGKVEYVPTTVKNISSTNCQDFNYLEPDYICRETQFISKSAVRTGSMCSDSNKIHIAEKALHVDTSDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EP33</accession>
    <name>A0ABY7EP33_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZN423-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_025932</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="419"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="452"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="485"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="611"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="641"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="671"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="699"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="729"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="759"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="898"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1012"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1040"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1168"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1194"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1253"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1282"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1358"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1389"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1426"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1454"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1482"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="509"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="573"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="926"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1495"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="929"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1495"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1525"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1562"/>
            <end position="1571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR11752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1577" mass="174133" checksum="4361AC0C836D6428" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPC2</accession>
    <name>A0ABY7EPC2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G3ST1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_035509</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the galactose-3-O-sulfotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009729">
        <property type="entry name" value="Gal-3-0_sulfotransfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647">
        <property type="entry name" value="GALACTOSE-3-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647:SF87">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06990">
        <property type="entry name" value="Gal-3-0_sulfotr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="363"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR10433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="513" mass="57330" checksum="C234C615A4ECD94D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPF8</accession>
    <name>A0ABY7EPF8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="47184" checksum="FEE5A12316A5E709" modified="2025-10-08" version="1">MCGNTNARRQDRQSPRQDNVQQRGCLRQQQQTRFQRATTSGNIDTSQQTRTTALQNHEKPYGFYLSDVLIEKNVHICGLSERWLYPHNLHFLNALSMNNNVYAKCDKDLCVTSAKGAGKGGVALLWHKQLDHVVSPLPIDEDRLIVYLPCSNHTSLIFRDYIDKLYDLWCNYSQWGTVVFLGDFNAKYTADSPVTRASHSYVSYDDSCQTLIDFICIPAEIVYTCTHCEMIDDNCLNTSRHRPVLCTLKLGDTISESNYTNADVNLQINWNKTRPEHISEYNTLLQDDTELNNIIHSELGIDSIDNAYDIIRNKLNEYSSISLPRKKFVPNLKPYWNQELSDLHSTMTSLRVKWCSEGRPRSCNNKYSADYKNAKRRFRRLHRKSVNTYLTTLDMELDNAAELDQKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQ20</accession>
    <name>A0ABY7EQ20_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_036128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="170"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR11052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="260" mass="30626" checksum="4B3AD918A7FD1EFF" modified="2025-10-08" version="1">MFATLNEIQSEAQRVKEEVDSKKERSNNRAVECNKELDDFENKLKRKVEDSISSFRQEVSNLNDEIIEACSCISSICEEKVAWAIKEKSQLNEIVKNSFSGRFYLMNQNFEKEISEVKRQIKEVEYKRTVRLFHLTENTTAFKCFIEDLKDVCQLQEEVVGSDEGNTYTMGKATQENQEARLKAEEELKRTEEDLAYFIQARLKAEEELKRTEEDLAYFKRECGMVQKQYRQAQKCIYWKQPTGSLKVEVSQEQRFPIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ER20</accession>
    <name>A0ABY7ER20_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WRIP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_025747</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR11567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="388" mass="42483" checksum="A154B5E1D6B46CE1" modified="2025-10-08" version="1" fragment="single">MSAENVLPCPICAKSFSSDTINQHLDNCLNPGDSIQLADTLSVPQSKKRKSDQDESSGKGWGFLMGPSSGVGSKRPKLGKPGEQPRSSKTIVIDADEDSNDNHSDGKIEQCKIEIEVSPVERTAHSLRKESTAETNVLSNASQSKTSTIDMGIPLAEQMRPSSLEMYIGQDKAVGKEKMLAHLLSSDVVPSMILWGPPGCGKTTLAKIIAHKCKIKSKFVQLSATSSGVNDVKEVIKKAKNDYKMLRKRTILFLDEIHRFNKLQQDSLLPHVEDGTITLIGATTENPSFQVNSALLSRCRVIVLEKLDADAVMKILVRAVERLDFEIIEEKEEKSKVTRCIEKTALDFLANVCDGDARVALNGLQVVIQSQLATVTNEMKTVVITTNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ESS5</accession>
    <name>A0ABY7ESS5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Uridylate-specific endoribonuclease</fullName>
            <ecNumber evidence="11">4.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_035317</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ribonucleotidyl-uridine-RNA = a 5'-end dephospho-uridine-RNA + a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA</text>
            <dbReference type="Rhea" id="RHEA:67792"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17354"/>
            <dbReference type="Rhea" id="RHEA-COMP:17356"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173117"/>
            <dbReference type="ChEBI" id="CHEBI:173224"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ENDOU family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.-" evidence="11"/>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd21159">
        <property type="entry name" value="XendoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039787">
        <property type="entry name" value="ENDOU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037227">
        <property type="entry name" value="EndoU-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018998">
        <property type="entry name" value="EndoU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12439:SF42">
        <property type="entry name" value="ENDORIBONUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12439">
        <property type="entry name" value="PLACENTAL PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09412">
        <property type="entry name" value="XendoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142877">
        <property type="entry name" value="EndoU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51959">
        <property type="entry name" value="ENDOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="EndoU" evidence="12">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR10241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="145" mass="16089" checksum="25D54770F5A4AA34" modified="2025-10-08" version="1" fragment="single">YVNDQYYFSRPTYAALLSLLDNYNHAVGSAEHTSAQESQEVTSFLDEISKTTIWFATYPRHGGTYDSSGFEHVFVGETDSKGVTKALGSFIYGTSPEFDIAMFTVCYLTHKNQHCNFSVDGHNMEVLTYEMTHGGGGHLGTGYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWM9</accession>
    <name>A0ABY7EWM9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NCDN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the neurochondrin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008709">
        <property type="entry name" value="Neurochondrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109:SF7">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05536">
        <property type="entry name" value="Neurochondrin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="638" mass="71259" checksum="2A17F82DAEA8E6A8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWP2</accession>
    <name>A0ABY7EWP2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GBP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_003810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="7">
        <location>
            <begin position="307"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="211"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR13705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="421" mass="47447" checksum="691393B79EC6F528" modified="2025-10-08" version="1">MEVSERNVDSKLTEGSAELTPLCEPCRADGKELEAHGFCNNCNEYMCPSCIKVHGKLTATKHHNVLGKQKMPTHYPARKKAPDVSCLELCKDHPPEAIKFFCPTHAQLCCGDCIVLDHRACKIDYIPRVAPSFTASSEFKAIVKKVETLEVACTNSERNLEAHEQSVLELNIIEIKKIQAFRVEINEYLDKQEKALIKFMDDAKKKDTDCIRRWREDINAAKLTLAETKSRLKDQNTASNIYIAARHAENLLNDIQTMIMKAKTENLLTGYKFCRDKKTEELLSWNDALGRVDQICDDVLDEISRIDKPCVIVAIAGLYRTGKSYLMNLLANSQTGFAIGDSIESKTKGIWVWCRDHPEQKNTVLMLLDTEGLGDVDNGDSNHDNHIFTLATLLCSTLVYNMKGAFDQDAVNKLTYPLVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EX52</accession>
    <name>A0ABY7EX52_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="178" mass="20049" checksum="933408BB411F298A" modified="2025-10-08" version="1">MRLNFNLGGFVEVALPFSKNRKLFVAEVIDVQEDEVLFRYMEAARGGFKWPTVEDVSWEHHSSVTRHLDNPVLDIQKSSNHVQIFKMAATLFVQPLDLVKNRMQLSGYQLDLEDELNFFGFELTEIEVAGTSKIGDDIKSDDTNTLDKNMDANCSICETGVGGRSEPQNADNNNCSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZK7</accession>
    <name>A0ABY7EZK7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_005468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035848">
        <property type="entry name" value="SH3BP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15126:SF4">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15126">
        <property type="entry name" value="SH3-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="23"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR15363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="486" mass="54930" checksum="6E3DEC81017230F8" modified="2025-10-08" version="1">MTDKAKQTPLKSIGAQALVELSRKCFHEKLRKKDKFRSLFRVKWSQKFVVVAHACLYIYGDEESKNYDTAFSMAVFKCVNEHKNGDRYFYLTFNDPDWEHIVFCCDSNKSQKKWMKTLKAAIDQASDSGIGHDDEAEQTDDEDSDDETDNISAMTAAKRPDTYMQINDSDVLSTALQVEPRSAVLMPQNHTRKEHRDDMDNHSKLKSTNYRLSSSSISSTDSESAYLIVSGGKESLVPTETESINTIGHVSVRLGNSPTALKKKGKSTKIPVNKHDQPTPKLSTTIRKTLPRSSQSAKLQEDMEARLHKKEHADDQTLTLKMKRAKELVNHNPDDKDENCYEDVLQGRGTHDISTDHLGNDGKHSHGQRQIKRETESTNSIGHVSGRQDNSSTALKKKGKITKIPVNVHGQPTPKLSTTISKTLPRSSQSAKLNEEMKALFHKKGNSHLTEIFVSFDESYLQIEHLYENLKRPAQKSVKRDTDKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1Y5</accession>
    <name>A0ABY7F1Y5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="438" mass="47213" checksum="D85262799E9AD5B1" modified="2025-10-08" version="1">MGIWQVHALSSILKTPIQSVYPELGNRNVRKDMHKLIKPVSGTDKEPQVFVMWTSNRDEMGTANEIRKADGTECTFKEFMKSSVDRLNIGMGKVDGANNGTKSDSKDTSSKVNGSNGGTDSDSKDVDAKVDGSNGGTDSDRTDDDPKIDGAKVGTDSESKDVKEKVNGSNGVTDSDKTDDDPKIKGGTGSDSKDADEKVDGSNGGTDSDRTGDDPKIDGAKVGTDCDSKDVDEKLDGGNGGTAGDKTDDDAKVDGSNGGTDSDKTDDDPKIDGAKEGTDSDSKDADAKVDGSNGGTESYSKDAVANDDREQHETEHVNTDLNDHEGVSMGEKHGNKISDIDTNFDTCMYEEKHVLVNFNGKAHVGIVKETNLSSVLVDCMRRNGKKDKNSFCWPIKIRDTNWYQLTDVIAIVECSDIPGQRNRYQLDEKSWQMYSSHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3A2</accession>
    <name>A0ABY7F3A2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="127" mass="14888" checksum="1BF459AAD7D89ABF" modified="2025-10-08" version="1" fragment="single">MTRKIIVNEAFLRNTSFQGQFLSKPTTHGLQNEKMLRLYAVVCDKGLVRLLEVKSPYSARKYTLQESNIKEFCLKWHGDNIVLDETHNHFFQVQGQLLVSGLHFCDFVFYFEYGIFVQGIQTYINIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3L8</accession>
    <name>A0ABY7F3L8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="62" mass="6840" checksum="1385D3F7288F7C11" modified="2025-10-08" version="1">MNVKKSTSEKVDSGILQLLQGTIPDIVDRQLDAQMTLQAIAKIIEDYEIRQLEGLPGKSGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F6K6</accession>
    <name>A0ABY7F6K6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RHG27-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_031040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="163"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR16446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="415" mass="48195" checksum="FFC25EA6B4D155BA" modified="2025-10-08" version="1" fragment="single">SLLCGVLYIRNRSTLPSTVWQVHQQIAEEISYHRIRIQNMLRLSPQNLQGYQENEMTIMNQSKQFLYPKDQMQHALEDKKRCLKLAESFAETEISTLETKMERKESTLKLVQRFSDAEITRLEDEVNECLHLKYVLEAEVAFLSALTALDGLQNTVSSLQKRVKELEAIISRKHWSMNFTQLDGSNIVFYVPWNDSQPTKDYPHGKPELIVPLLRCKIKKDCTDYTSKKNTFVLKTSDKMLLLQADNETDMQKWFLHIQRKITELGGHPDMTGSSLLVPKKMVKQVADRFVKKRLRPLETKGIVNDAIFGGDIKEICSKEKSEVPMFLVKCIDAIESRGERYDLGDKQWDIHVLCGILLLFFRKLKNRLFEESLCETVMNLQRENKMGVHQLAFVFGPRLDFYILLAENVLQNVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8I0</accession>
    <name>A0ABY7F8I0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">E2F3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_032263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd14660">
        <property type="entry name" value="E2F_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032198">
        <property type="entry name" value="E2F_CC-MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF107">
        <property type="entry name" value="E2E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16421">
        <property type="entry name" value="E2F_CC-MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="7">
        <location>
            <begin position="129"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="265"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR17669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="366" mass="40793" checksum="6E50CC2800ACA769" modified="2025-10-08" version="1" fragment="single">MSGGGFITNRRYSYPVIKQEQDDTLESAQIMNLTSIFSSPTYRSTQTLAHIKEENGQWNYVTNSQGSTPSGHSYRPLAENPPSGRSQAKRKLELDVQNEGFKTPAKSYKRQRTHSEKSPKVRSPLEKTRYDTSLGLLTKKFVGLIKSAPDGVLDLNRASEYLSVQKRRIYDITNVLEGINLIQKKSKNNIQWKGCTNSIAANPRLNEQQNIRSIKSLDEQTVIAIKAPPETRLEVPDPGDNIQIWLKSSKGPIEVYLCPEEVGQNSDSSNTTSHSDSACSNTSASSGDDSFFSEDSTSCDSFKDISPDLGQSLLMQTEDQHSDDNFVQLEPPIGALDDYMFSLEETEGISDLFDNYLSELPNIDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8L8</accession>
    <name>A0ABY7F8L8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PSMD8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_000351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="2">
        <location>
            <begin position="104"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR18513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="166" mass="19174" checksum="1B397FB158A38CD8" modified="2025-10-08" version="1">MASLKEIVIMYQSLKREWDKKPANLDRCGELLSKLKIALTQVSFLPTDEAAPSKQELLVARDILEVGAQWAIAKKDIPAFERYMAQLKCYYMDYKDNLPESTYKYQLLGLNLLCLLAQNRVAEFHTELELLPVKELQNNIYIKHPVSMEQYLMEGSYNKVGYSTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9H1</accession>
    <name>A0ABY7F9H1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">EPDR1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_000603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF1">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00811">
        <property type="entry name" value="Ependymin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR18765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="228" mass="25896" checksum="5960B2BB34C70B93" modified="2025-10-08" version="1">MNREFSKSHIIVLGLEAQFVLSRRPLSSAHFSPDKAAMKTLIALLAFAAVCYGQVPERCESPKQWQGGRLSTVASRSSKRRSFFYDEPGMRIRTIEEIDVGKERDYYDVLQLHKENKEYRVNLRTKKCNVTSIMFPFRQVGVPPEAKFLFMGEFGPASIQFEHLTAVTFAGNATVDNIRYTTTVTYPDCVPIGDNYYNDKTGFVESRYFDISLGISEPEAFLPPSVCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FB11</accession>
    <name>A0ABY7FB11_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CAF17-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_001138</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="4">
        <location>
            <begin position="52"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="CAF17 C-terminal" evidence="5">
        <location>
            <begin position="262"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR19300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="338" mass="37589" checksum="A12521838E90DB96" modified="2025-10-08" version="1">MTLTLRITFKRTSDKFKESTMGFQLILRTARTKIKLLKFSHINARNLSTSSGRVEVYQLRSRGIVKVKGSDAVPFLQGLITNDVSLLGVDGKAQYSMLLNVQGRVLYDLFLYDVSESHVDRTILMDCDRSLLKKVMSDISRYKIRKKVTLEDASEKLNVFTTLNGDHVDGGLVATADPRVPSFGSRVIAEGVPDSWCVVSDETGYHEKRLQWGIPEGPLDIPHGVALPLESNLVYMNGVNFSKGCYLGQELTARTHHTGVTRKRLMPLIFDGNPDAIESGQNIQNDQNKSVGKFRSVVGQYGLGLMRVKEISGDLTVTSKSGKVISVRAEQPAWWPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBK7</accession>
    <name>A0ABY7FBK7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FBCD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_001396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="76" mass="8243" checksum="557A44BE942CB078" modified="2025-10-08" version="1">MCIAGADVNYNAVLNVHDSCGSTHSTDVKPKDCTELHQFQKQSGIYTLYPDRAMPTGFNVSCDMDIDGGGWTSILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FC39</accession>
    <name>A0ABY7FC39_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CP4A4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_001010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF201">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 4, SUBFAMILY B, POLYPEPTIDE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR19172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="448" mass="51405" checksum="054A2F41C0125F00" modified="2025-10-08" version="1">MGLLVTLVMKYLPLVLGFLIGKTIIKLVLRRWELQKIFKAFSGPKPHFLWGNTKELFGDYQGLVRMAELAHVYSGAYPAWTGPADAQLVIVTSGTTRAVLAGADPKDEFSNSLLGPWIGDGLLLSHGKKWERTRRLLTPAFHSDNLKNYIKTFEECSKELVKKWQHSTEPEEVFQHVSLLTLDIIMQCLFGFHSNCQSGSVLHPYIQGVYDVSELVAKRVVNPLYHYKFIYKLSGNGKRFQAACDAIHEHSERIIRERRSLIASEKPGTRNMDFLDVLLTAKDRDDVSLSDKEIRDEVNTFIFEGHESTASTITWFLYNMAKHPEYQNKCREEILEVIGKDKEITWSWVHRDPEVWENPHEYDPERFHPDKRVSSLIHMPFSTGPRKCIGMQFALTQVKVVACEILRNFHIDLDPPHEATPESILFLRSKSGVYLKFIKLPVEGVPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDJ4</accession>
    <name>A0ABY7FDJ4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_000742</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF14">
        <property type="entry name" value="BM-40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045229335" description="Kazal-like domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="99"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR18904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="331" mass="38111" checksum="6362D873D3046036" modified="2025-10-08" version="1">MELPLLLLLAVVGYLTNGAAGNYEYDPDYLVPSKCRACDVKSCPQLTFCAGKMVKDHCGCCQRCSSALFQPHVPYRPDPPLAPTASPPTLPTQPGDVCEKRQCPKFKVCAINVQGLPICTCPSEYICRRRRANRNKRGKDEPTVCGTNGVTYESRCHLKIASCSSEKRIKRKHDGPCTAEDIDETKHAVMTETAPDVGEYFPDRDTAIQTTHVNESEKARLRKLKKKQKRKERKERKQRKREKKRRRKNNKDRDSKRKARSRRMKRRNEGFNTFPSNYEYLINRHTRWSTNQENYHFVPFEADYKDYSHIYARALGESRVLSDSSIGISRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FED8</accession>
    <name>A0ABY7FED8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TENX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_002353</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="327"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR20515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="757" mass="83415" checksum="646926C0D9DE31AB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFA4</accession>
    <name>A0ABY7FFA4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TGRM1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_001677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF87">
        <property type="entry name" value="CRESCERIN-LIKE PROTEIN CHE-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="35"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="294"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR19839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="642" mass="71854" checksum="02B7B0208D4F7BA3" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FI74</accession>
    <name>A0ABY7FI74_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11397" checksum="643A22834BB994AC" modified="2025-10-08" version="1">MDANNNYIHVAIRHGYFLMDYYKDGVWRNVPADIVYPGIVGQVQELTLAIYSDHCQVFLDNKFLGQSENTQQASKITEISICPENNAVVEWHSVDCKDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJ77</accession>
    <name>A0ABY7FJ77_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_016239</name>
        <name evidence="2" type="ORF">MAR_016605</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR22265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="139" mass="15092" checksum="9A57D5099D05E1A3" modified="2025-10-08" version="1" fragment="single">HFTAVAAASSNLSCHDCSESFKKIWTPYTECQYYPEVTPLRPCLDTDRYCKVCHNDKQSALAVERTTYNQMTVSISRGCTNECWHGCHPSGFGLTRYKCTSCCLASGCNTGNTATGLSGHQGGICVGGTLLFISLLALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJN9</accession>
    <name>A0ABY7FJN9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027871">
        <property type="entry name" value="DUF4603"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17611">
        <property type="entry name" value="DNA SEGMENT, CHR 5, ERATO DOI 579, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17611:SF3">
        <property type="entry name" value="DNA SEGMENT, CHR 5, ERATO DOI 579, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15376">
        <property type="entry name" value="DUF4603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1364" mass="153727" checksum="A17E3331BC09C508" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FK04</accession>
    <name>A0ABY7FK04_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_016451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056564">
        <property type="entry name" value="Ig-like_KY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053041">
        <property type="entry name" value="Transglut-like_Superfamily_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020:SF1">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23265">
        <property type="entry name" value="Ig-like_KY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KY-like immunoglobulin-like" evidence="2">
        <location>
            <begin position="335"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR22477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="599" mass="67607" checksum="6AB3630AFA146E4C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FL84</accession>
    <name>A0ABY7FL84_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160:SF10">
        <property type="entry name" value="MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="181"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="401" mass="46393" checksum="27A5D77DDBE0FF89" modified="2025-10-08" version="1">MTFNLEFSMGLADICVDDGVITQHTSSDRPRNTPQKRNRKARSMSLGEAALTDTIVEDDGEVEFEVCGDSFTRGTARNHLADSLMKKRVIMKILISKYFLLSDGKLSEIFMHLPDESSTTRWLRRSAEMTLICHALGLGQTFNADYLGEKFLVGDVRVGDKRHMMFATADQLCLLQRTRTLYLDGTFRVVNKPFTQLWSIHAFLRQGATKHVPLLCVLMSRRRKNDYEAVVLRKIVELMDVVPVVEAFAMDIEAGLWQAFQEVFPRSKLHGCGFHWAQVIQRRVQAVWLHATYERREGDHQYVRKVLALPFLALGDIPRAFRKLKDCSDGSSEQLRELFHYVSDQWIDNSMWSPDEWSVYRKNVRTNNDTEGKWHLRMNARAGRGKLKFYILLGLRQRRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLE6</accession>
    <name>A0ABY7FLE6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AQPA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_015841</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR21867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="187" mass="19750" checksum="7220BEE2E9EE0929" modified="2025-10-08" version="1" fragment="single">KPCRYQSYINPQELKTWSLWRAVLAEFLATLLFVFIGTMSAVDIVPITDSAGKFVRIGLTFGLMIAVCIQMFGHVSGGHMNPAVSLAMAVAMEISPARAVLYTVAQCCGGMLGSLLLKGVTPGALNDNLGLTTVKPDLNGGQAFACELVFTFILVMSIFGCTDPSRALFGSPALGIGLTVSVLHFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FM30</accession>
    <name>A0ABY7FM30_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TC1D1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_036937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd21451">
        <property type="entry name" value="DLC-like_TCTEX1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35151">
        <property type="entry name" value="ELONGATION FACTOR 1 BETA CENTRAL ACIDIC REGION EUKARYOTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35151:SF2">
        <property type="entry name" value="ELONGATION FACTOR 1 BETA CENTRAL ACIDIC REGION EUKARYOTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR23268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="704" mass="77542" checksum="1060E3D5D2C744E4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMQ5</accession>
    <name>A0ABY7FMQ5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_037162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046329947" evidence="3">
        <location>
            <begin position="26"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR23493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="132" mass="13877" checksum="4B9B0CC4C4F2F760" modified="2025-10-08" version="1">MKIVSATLMACVLLALSVHFVRVKGDSEEQVLKTTQQPANTSSDIVTVDTESGNGPRSEKQVDDCGLGRHCSNGTYCCHNGGCCPHGWSCCSLTHCCAGAAGLAGSTLGHTMVILCCIAGYFIAKQDKHILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNM5</accession>
    <name>A0ABY7FNM5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 2 subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_036861</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR23192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="286" mass="32334" checksum="8DC2CAB26D849E37" modified="2025-10-08" version="1">MVLSCRFYANKFPEVEDVVMVNVRSIAEMGAYVHLLEYNNIEGMILLSELSRRRYQALSLGVVTLLCASILRHVGELLHYKNDTQLEDLYMKTAWMFDEKLKKPTACYEIFKHAVTNPATLDECDIDENTKEVLLENIKRRLTPQSVKIRSVACTNYEGVDAVKRALKKGLELSTEVMPIKINLIAPPLYVVTTQTLDRGEGLIALNKALEAIKASIEEAGGMFNIQLQAKVVSDLEEQELAKKLQDLEDENQEVDGDDDEEDDDDDDDGNDEDKDKSEPEDEKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQZ0</accession>
    <name>A0ABY7FQZ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037205</name>
        <name evidence="2" type="ORF">MAR_037243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR23536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR23574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="96" mass="10652" checksum="42A5548C5005AD89" modified="2025-10-08" version="1" fragment="single">MVILASKTLGISEEGSLGKLDLALSWEVVPCSATPENPCKRLVDLAIDSTNFEVHVAEVEPIQAYDREFMFDWEDKLIEGEDEKKVRKSVVNGTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSX4</accession>
    <name>A0ABY7FSX4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABLM1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_016290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032402">
        <property type="entry name" value="AbLIM_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051618">
        <property type="entry name" value="Actin-binding_LIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213:SF9">
        <property type="entry name" value="UNCOORDINATED 115A, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16182">
        <property type="entry name" value="AbLIM_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HP" evidence="6">
        <location>
            <begin position="304"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR22316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="369" mass="42407" checksum="EFF7B722851ED1FE" modified="2025-10-08" version="1" fragment="single">LNFQDSSYEKRTEMNFGKFYNQSYLKTGSQKYVHRGRTLSEPKGKNNVNQFIRPGGMQTLAQGKTVTKTRRSSSPGPQGTPPPGTKTGIRQNLEAVRMSTFPGGKPPPPREIAKIERDDWPAPPSPAAILPEILRQRRKSRGEEDEEEEEGVFEDPKIKREIEELKKFKDESGIGKVIYNELEVAKSLPSKPLDPWKSSRVPNAKYEPKYQTRYQSPMFASPSRFIDRSRRSWDDIDIRGYRTISVVGNFPAPKPGYGLDPRAATLPVSGIYGGPLDLDFVTSTIFDQPGVSLMTFQKSSWHTDTKPPEYQYERLKISNFDLPRDVDRNMLEIHLPDGEFSDIFGMEREEFRHLPEWKRNDMKRKKDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUQ1</accession>
    <name>A0ABY7FUQ1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CABIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_038125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025946">
        <property type="entry name" value="CABIT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12736">
        <property type="entry name" value="CABIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CABIT" evidence="2">
        <location>
            <begin position="21"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR24456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="625" mass="70592" checksum="9D7FBADCD62F8199" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUY3</accession>
    <name>A0ABY7FUY3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_038322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="223" mass="27175" checksum="E439ECB01739D4F7" modified="2025-10-08" version="1" fragment="single">MTIWGIYEEVIMTTWGIFEEVIMTTWGIYEEVIMTTWGFYEELIMTIWGFYEEVIMTTLGIYEELIMTTWGFYEEVIMTTWELIMTTWGFYEELIRTTWGIYEEVIMTIWGIYEEVIMTTWGIYEEVIMTTWGIYEEVTMTTWEVIMTTWGFYEELIMTTWGIYEELIMTTWGFYEELIMTTWGFYEELIMTTWGIYEELIMTTWGFYEGLIMTTWGIYEEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FV18</accession>
    <name>A0ABY7FV18_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CLCA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013642">
        <property type="entry name" value="CLCA_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041940">
        <property type="entry name" value="choice_anch_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08434">
        <property type="entry name" value="CLCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcium-activated chloride channel N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="536" mass="60673" checksum="010E4E1B1EEB454D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVS6</accession>
    <name>A0ABY7FVS6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NOTC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_010657</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR24953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01983">
        <property type="entry name" value="NOTCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="494"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="531"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="569"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="607"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="645"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="684"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="723"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="783"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="821"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="860"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="897"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="936"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="975"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1018"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1059"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1098"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1138"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1176"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="864"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="885"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="924"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="963"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1006"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1047"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1086"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1126"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1164"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1202"/>
            <end position="1211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR24953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1265" mass="136074" checksum="EB1CEF2E5273CEA5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FY14</accession>
    <name>A0ABY7FY14_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RAP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="13301" checksum="E5500FEC81167DBB" modified="2025-10-08" version="1">MTKSVPMILVGNKCDLEDERVVGKDQGANLARSFNSEMCGFLETSAKAKINVNEIFFDLVRMINKKNPETTKRSKNKKGCVLVLFRFVVYTYTDTVDDFPTRWKAFFNMKKKLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FY15</accession>
    <name>A0ABY7FY15_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR27088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="164" mass="19177" checksum="B10F5D998CCDCA50" modified="2025-10-08" version="1">MKSVEEESLTNINELRKFRTEINKYLDKRENELLAEIDQKKQTSKMLLSDLKSKCTNIKSDSEKLKSELPAHEANNMHLFVVGKRTMKELAGLQTAMEDVDRKRKVPRCKFHRDPATEQLLAFKNAIGRLEEGKSTSALWQQHRQQEMKQQQHKRRLVTSQKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYK1</accession>
    <name>A0ABY7FYK1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="180" mass="19644" checksum="6354C6A00B8BEAE2" modified="2025-10-08" version="1">MTCVFLTCGGNGFCSSLLSIVVSVTFSFHAVGLFSPFWFCEGPGCHLTGLFFTCSDGSCSINVENTGLLVVGLIVFASSVFLVVTTFIVFNCTSYKYLKLDPHLALGFGGWFIVQEILTIVLLVIAAVKYDRLGWSIYIFTVGGIFCMFIVILIVLYHWCKARPSVGSEGTNPIPEKDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYP2</accession>
    <name>A0ABY7FYP2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MTR1A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_011748</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF75">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="572"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="54"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="428"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR26044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="760" mass="85693" checksum="052027333FC8320F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZF1</accession>
    <name>A0ABY7FZF1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TNF family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_013234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR27530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="38607" checksum="A99C5FCCCF109ADC" modified="2025-10-08" version="1">MESDMYIPNYKMDAEIIPNVEKRRRRWIRIICILSFVFMLLISFTSHLVNHIEVQNLKRELKTTKDKANDLIHAKQLDLEMQRKHRHSHKVDGLSEITSRLGAGKRRRRHNSGATPAFSFKGSDGQQATPVYGQQQFWQAHRVRRRTAYLTLGLELWAFHPYNNQSTQLDSAYGVQVSRGAEYGYGYDDFPTDSIEVSGLYFIEQNDELFVKKVIFTKIRILQTGQYYMEAKIAIEGRDREEYSGYLRVGLELRKTLGGTSQVLDKTYLTQDHSNFPNQPLDTISVAGLFCLKLNDVIFVAISENIPFSPIFKTGPEHARFDAYMVNSENDYCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G021</accession>
    <name>A0ABY7G021_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CADM2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_013512</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046880444" evidence="6">
        <location>
            <begin position="23"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="8">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="8">
        <location>
            <begin position="135"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin subtype 2" evidence="7">
        <location>
            <begin position="141"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin subtype 2" evidence="7">
        <location>
            <begin position="363"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="8">
        <location>
            <begin position="423"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR27808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="563" mass="60971" checksum="49614409004504EF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G183</accession>
    <name>A0ABY7G183_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTBD6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_013694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR27990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="399" mass="45381" checksum="F869163E66A937F2" modified="2025-10-08" version="1">MSEAWQHEEPFAVTNVHMLDADVLCDVTILAGKEKQEVRCHRFMLASRSPVFYTMFCGSLPEASVVEIPDVEADVFRTIVRFMYTGEIQLMPDSVMATMYAAKKYDIQPLTNRCKTFLEKEIAVENVCIILDQASKFEEKELIQQCLSFVSENPDLVFESDGFLSISSETMRYVLEQEKTTPKLPPEEVYASCKKWAKQSCSTTGLEVTDQTLRQKLGELILLVDIAGMSFESFTYNVVQENILSDSEKVTFLKELGERKKNVNSFRVERFSNGIDGWGYQGKQDGISFSTSKGVVLHSVALYLPCQPGSLTGSLEILEDQIVVLTQNVNLYYQNDTRYEYIHLDKKIDVRQGVIYSVRQRLRGENSYYGEKYNGKSDNGTSLSHGQIYGLTFKCSKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1Q0</accession>
    <name>A0ABY7G1Q0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PRP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_012635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="131"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR26931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="306" mass="34814" checksum="0920271678E90D00" modified="2025-10-08" version="1">MKTTHYKTTDYKTADYKTADYKTADYKTTDYKTADYKTADYKTADYKTADYKTADYKTADYKTADYKTADYKTADYKTADYKTADYKTADYKTTDYKTADYKTADYKTADYKTADYKTADYKTIRMSLSGKEKKRGPNWTIEERNTLIELCRASTNTLKMNWGEVADRVNSIGGNSRVAPEVKKKWTDMKVLTTIPKVSVDGIPGGVQCGVSSNQESNKEEEEEEEEEEEEEEEEEEEEEKDMIQGAAANVKDRSSSVKFSSCNATGGSTSNLQLRMVMAQEQQNSILSSIDSTLKKIVYKLMQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G227</accession>
    <name>A0ABY7G227_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BRF2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF8">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="238" mass="25531" checksum="87FBD3186721DD77" modified="2025-10-08" version="1">MISERIRSSSTFFSASYATRWGCLGPGKISYDFFLAIQDNLPAQEHELEMNVKLVTNAKLDTNAKLDTNAKPDTNTILDTNAILDTNTKLDTNAIPDTNAKPDTNAILDTNAILDTNAKPDTNAILDTNAKLDTNAKLDTNAKLDTNAKLVTNAKLDTNAKPDTNAKPDTNAKLDTNAKLDTNAKLDTNAKPDTNAILDTNAILGTNAKLDTNAKPDTNAILDTNAILDTNAKLDTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G269</accession>
    <name>A0ABY7G269_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042838">
        <property type="entry name" value="KIAA1958"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46963:SF4">
        <property type="entry name" value="HYPOTHETICAL PROTEIN MGC115716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46963">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA E130308A19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="223" mass="25714" checksum="DF9A31875A69E96C" modified="2025-10-08" version="1" fragment="single">KRPPQCRCRNAHHKQSCPNGDKTETETKKNTNTGNKTRSHMKLIQDFLVQKGEGRPIQEIPPHDMDMILQEFVMRIRQRDESKYEPSSIRGITSSLDRQLMWGDIQLGIEGTEEFLEFNERQTKTRTGSDTNNVRRQKPGMYATGTERCQVVTYKQYADHRPMNFSGDDHPFYLAVVTNKVAPIGRNKLDSIMKKMAERAGLPALMNGKRLTHTTKDSPFQIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G272</accession>
    <name>A0ABY7G272_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="1">
        <location>
            <begin position="2"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="531" mass="60886" checksum="26ACC1F4DB66351B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2Z3</accession>
    <name>A0ABY7G2Z3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_013391</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tumor necrosis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471:SF13">
        <property type="entry name" value="TNF FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471">
        <property type="entry name" value="TUMOR NECROSIS FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00207">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50049">
        <property type="entry name" value="THD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="THD" evidence="6">
        <location>
            <begin position="102"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR27687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="262" mass="29931" checksum="18636C84D9FFF51D" modified="2025-10-08" version="1">MSNPSYFYISIAIVILCIVWTIPDSKQIDADTEICLQHENKIMKCGETISVLHDVFEKAILSAYAAAEKQEKNQTEKYIQDALKHDVQLMTDYKNTLWDMKPSAKLVGNREQQKHVSGNAAMTTVTCWRHDKDLYYTTGFQRYGIRFQNGRLIVPVSGTYHIYSFLGLTERGVTDEGIPVKSNNTQEIIHTMHKYNVLDTADIEIASNVQSRKNASRGNFNYYTSQIVTLVKLRAGDEISVRINDEALLQHTENNYFGLHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7D0</accession>
    <name>A0ABY7G7D0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AJM1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058586">
        <property type="entry name" value="Ajm-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038825">
        <property type="entry name" value="Apical_junction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21517">
        <property type="entry name" value="APICAL JUNCTION COMPONENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21517:SF3">
        <property type="entry name" value="APICAL JUNCTION COMPONENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26649">
        <property type="entry name" value="Ajm-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apical junction molecule ajm1 alpha/beta" evidence="2">
        <location>
            <begin position="2430"/>
            <end position="2544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1411"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1473"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1561"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1625"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2007"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2070"/>
            <end position="2207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="968"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="978"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1422"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1480"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2070"/>
            <end position="2079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2087"/>
            <end position="2098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2181"/>
            <end position="2202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR30333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2705" mass="302775" checksum="2088018010B65F63" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8V2</accession>
    <name>A0ABY7G8V2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046644092" evidence="1">
        <location>
            <begin position="23"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="254" mass="27667" checksum="C0BB459FCB560879" modified="2025-10-08" version="1">MAVIGVFMLLLTLSMKVPSVSSLTNYEFYKAIEPYISESDADYPDGNQTMEESNDDDIIDIPGGPNDELDVEFLANALGIISAVDEENEDDVGTIITTTTTTTTITTTTTIIITMRVLRATVKVTSVNVVCRKGSASRSYGKGSSLHSEIKRFRVHLKLGCFRIPLAIEDGISPDQVTDDGEGWNKHRSLTEMFSDLALPLDQVTSDDMALSLDQIASDDFALPPDQIASDDLALKFRALAESVEGTQNDDSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8X1</accession>
    <name>A0ABY7G8X1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047194725" evidence="1">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="95" mass="10999" checksum="A222142A4E850A0B" modified="2025-10-08" version="1">MLPFLLMQIFLGNLTVNWDKLTVDNTSLYVDLLMNDRELYSLKYYSINNAAIDNACNLVKTLRNINSAFNMKRLKIAWCADGRPRLILCASYVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GA77</accession>
    <name>A0ABY7GA77_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C1QL4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_033869</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF102">
        <property type="entry name" value="CEREBELLIN 13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="131"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="42"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR31327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="260" mass="29268" checksum="6CAC705C10B34226" modified="2025-10-08" version="1">MYSSKQIRELFIILVIKSSLCEINEPRCYSRFDYEEKMLEKMVRTEVKMEELLGKLEELEKGLMNVKTEVDTSTKKIQDQEKKHDTEIEMTKKGIQALEEKYYILQTDLEKFENSTKSSLDALSRNITANMHHSPVAFFATLSSDLGTSFSPKTIVYNNVVTDVGGGYNPGTGVFIAPVDGLYVFSTSVMMILSTSTTYANVRIKKNDSHIVTLVVEDRDGQFETVTGTVILSLQVGDTVMVTSGRYIYGGYTFLSGFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBF6</accession>
    <name>A0ABY7GBF6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NS1BB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_034289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052392">
        <property type="entry name" value="Kelch-BTB_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46375:SF3">
        <property type="entry name" value="KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46375">
        <property type="entry name" value="KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR31747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="196" mass="21328" checksum="65D9909A9E30D5DC" modified="2025-10-08" version="1" fragment="single">FHNKIYAIGGTNDWKCLNEVEVYDPVTNEWSQHSHMNIARRGAGVDVYKGKIYVVGGNDGTSALNTTEIYDPESHTWTLGPTLMAQRANCGVAVMKDRLFAVGGFNGKKFLKSIEFLDLDIKEYWRKDAPLNGNGNRLSSDGSIKSDDGSARSDDGSTKSDDGNTKSDDGNTKSDDVIKNGDVNDKGLKNIDSGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBM9</accession>
    <name>A0ABY7GBM9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_033316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="208" mass="23881" checksum="6417AAF8686C05B5" modified="2025-10-08" version="1" fragment="single">MAWNSGSTCPSSTTDDQVNGNEVRSMVIRTFWTDRINMSNKTLQAFVAAAQFLDVLSDVNTQAAGQFSGSVNVCLRVTKNLVLDILFIFKTLTIEMLLLFRHYNREDEERVSNYLRQLFENAIQQGILQEEASQDPDREERGEQRDRDRDVADIVRHLVQELFREKRRVDYYKQSCVTLGIQVPDIGSAITLIEDFISGKMYSLFAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GFD3</accession>
    <name>A0ABY7GFD3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XYNB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047002">
        <property type="entry name" value="Tcp10_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="638" mass="69128" checksum="0E04EB0D33927270" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GFF9</accession>
    <name>A0ABY7GFF9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLPP6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_034378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd03391">
        <property type="entry name" value="PAP2_containing_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="3">
        <location>
            <begin position="98"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR31836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="236" mass="26335" checksum="BC6932E8E53733AD" modified="2025-10-08" version="1">MSTSRIRTKGKDSGKANGHIGGKSKKRKSANDSSSFLATILQLDEKYTSICAICANKDSPLSLLRPVMKLLEISCHGIPWLTGTVLLILSVHLAHHVEMSVNLLFGLILDLIVIGILKVAFRRSRPKHNEMDMFATVSIDNYSFPSGHASRAGMLACFFLIEYLSCPTKELLILAWSFTVTISRVVLGRHHLIDVVCGYGVGILEYLMLVYLWIPQKTCMSWLELYFNVVTADFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GJU7</accession>
    <name>A0ABY7GJU7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="151" mass="16904" checksum="FAFEB6A328349E86" modified="2025-10-08" version="1" fragment="single">MCSFDTHKCWPGRCPTSLTKDCVCAEGFRLEKNISHTSCQLSLNNTPTIINCRIQIRAGVGGKARQSPSGECKLQKDFFGNFQPRIVQFEMDAVFKIDISNITKPRFISESNFGVTDAKVYLQQKPIRGVSKLIDSYSFKNDQNASVNATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D8F2</accession>
    <name>A0ABY7D8F2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_006413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="211"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ93942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="300" mass="34068" checksum="4C27A85D1A5A7C5F" modified="2025-10-08" version="1">MNNAKRKQEIREKVKEMKMRQQNWMKQKAEFESKSSNGNSSSPVQRSPDDVTTKKSKPVDNIERGVRSSSSNDRNNNSTERLLASHKSNAKFASWLKAKEVPAEDEGLSLENESTFIHKSEYNSNKYSDNYYKDVDYRDHKGSGGATTLRVPSERTSKVTSPEQGWDSEDETGEITAATLMSPEDFDSRADDIIAKVKGDLKLSTHPTSVYEEVRKSVSAVNNKMDSLDSQDSNLSSHESEITELQRQLQDLVTHKKDFERSYDELAIQARQEKNRLTMVHDSLTSVHQQIEKVKMLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DA87</accession>
    <name>A0ABY7DA87_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CNOT9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="148" mass="16653" checksum="C4DB777C75437B71" modified="2025-10-08" version="1">MPQREGNFKPAQGSLLRAQKISATSYELEFHHWRLLSRMMNPGAAPPTSGSGSLMAGSSMSQAEREKVYQWIGELTSPDTRENALQELRHTSPIECVMLWPSYSVWRHILRHPQPSSLVATFIPQKILVGETGLSYILQTYDDSPTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAZ9</accession>
    <name>A0ABY7DAZ9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPRS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_006929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF46">
        <property type="entry name" value="SERINE-ENRICHED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="70"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ94458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="228" mass="26315" checksum="CC324817CB784944" modified="2025-10-08" version="1">MNDSSSGYDSTDIDVSDVDSDKSMMSQNASCPSKQRPTYQNDEQQVQAHVSSTKSLCESLKLIRDMPEMCDVTFLVGSDKTPIQGVRSILATRSKVMYQLIYNNIKKLEGRPSFGLRLTIPIHKYDAEVFRMLIQFIHCGTATINDQTVTGLLCGACQFELWDLEVAFWRYLRVRLISGHEETIIDGSRKYKQHRKYAFIMEQIYKYLDERYNDRKSSLVVKIHETEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBL2</accession>
    <name>A0ABY7DBL2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Y1918-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_007175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="119"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ94704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="198" mass="22318" checksum="5A0BA583E2746777" modified="2025-10-08" version="1">MTKFVKLSNGPKDHGKGRCRDACLGSLEKLGLSDIDLYLIHWPGTQGHAPGDAGNPTRRLESWRDMEQLYKQGKCRAIGVSNYTERHLTELLDQCEIAPHVLQAYSSLGTTVSPEQKNKLLHDETVLSVSKEVNRSPALVLLRWAVQQSIGVIPKSTNLEHIRSNLEVFDFKLTNGQMDKLTSLDQQHHYCWNSETVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBL9</accession>
    <name>A0ABY7DBL9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">KCNH6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_007533</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF548">
        <property type="entry name" value="GH12235P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="14">
        <location>
            <begin position="306"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="525"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="650"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="729"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="878"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="545"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="681"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="755"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="906"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAQ95062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="926" mass="103191" checksum="3E302B7451335C91" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DD55</accession>
    <name>A0ABY7DD55_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">COX12-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_006489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11387">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ94018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="13228" checksum="CACF0D98F3680B78" modified="2025-10-08" version="1">MADEATKEAPSMAERVKNTLAWTGIPVAMPAYDAGWAKGAAPFDSRFPHQNQLPNCERNYIDYQRCIRLKGEDYPNCNYFKASYLQLCPKKYVSEWDEQVEAGSYKYLPDNIPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDT0</accession>
    <name>A0ABY7DDT0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="527"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="593" mass="66219" checksum="76110F70C2B65FF1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DEV5</accession>
    <name>A0ABY7DEV5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_028221</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46595">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ95531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="101" mass="11284" checksum="5623C1ED599433DD" modified="2025-10-08" version="1">MKPKAAAVKTLTTGGKLVYLYKKKLGSVPKCGDCKAVKLHGITPARPKELMSMTKRLKTVSRCYGGSRCHKCVRDRIIRAFLIEEQKIVVRVLRAQQAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DEY1</accession>
    <name>A0ABY7DEY1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LYAM3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_028916</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050350">
        <property type="entry name" value="Compl-Cell_Adhes-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325">
        <property type="entry name" value="COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325:SF575">
        <property type="entry name" value="LOCOMOTION-RELATED PROTEIN HIKARU GENKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="131"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ96226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="176" mass="19240" checksum="E543BF2549671E5D" modified="2025-10-08" version="1" fragment="single">MTDTITVKKCIPPPTISFGSYDPVEPSGEHEYSTIVTYTCDLGYYHSDGDLIRTCDDNKQWTLTTPVCTIKTCPKPTEPYIDFVPNTATIDFNTTFTGTCILGYNHTNGNALRTCLDTYALDGSPMICSIVECAALPLPAHSSITNTVPSKYVYQDDVTYACNTGYELSGGDVVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DEZ6</accession>
    <name>A0ABY7DEZ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TSP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_006076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038877">
        <property type="entry name" value="THSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311">
        <property type="entry name" value="THROMBOSPONDIN TYPE I DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311:SF3">
        <property type="entry name" value="THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="431"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="930"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1178"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1426"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1503"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1503"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1521"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1899"/>
            <end position="1914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ93605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2052" mass="225369" checksum="A68008DB78867A5C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DG78</accession>
    <name>A0ABY7DG78_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NPL21-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_028390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="2">
        <location>
            <begin position="69"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ95700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="154" mass="17523" checksum="54ADA9971633E17B" modified="2025-10-08" version="1" fragment="single">SKGFVNLNLTDSIRFEGANDKYHSSDVTHADSTSPCTTPKPTEPERCKDDICTRLSADILVKMNVSKDPCQDFYEYACGGFERSTQLSWNTPRKRTNPDIVLENYQDAISDKLSEDVKPTDGEEVKAIKRVFQSCLGFQRNTHIEGFKHIKRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DH60</accession>
    <name>A0ABY7DH60_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ERI2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_029001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ96311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="188" mass="21496" checksum="2F80ADE1719F8728" modified="2025-10-08" version="1">MKSTKELARELGLIRKRTLSTSGINLRKGSAANDQPFKYLIVIDFESTCWQDGKFRTQEIIEFPAVLLNTETGEIESEQVDNGIPINLCLKRFSHWLEGLRREKGVVLPGTHGDRTINTTSVTWSDWDLGVCLQYECKRKQILRPPQLGSWIDLRATYRKFYDRKPNGLNGALQDVGITFEGREHSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIC5</accession>
    <name>A0ABY7DIC5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ97387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="167" mass="19405" checksum="C0B2A2D59FF8409C" modified="2025-10-08" version="1">MAIRGLKEKLTEKDLLLHIDFSENYACKYHEEIQSMHFGVSQKQVSIHTGVISREENYKGPEDCCWNNETSSEEVQFDDSFLGQYCVVLYDGKPFPGIVQEVSDQEVEVNVMQSVGMNIYFWPGMQDVLWYSAENFLNLIPPLTKVGTRHNQIEPSIWEEIRRHVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIQ1</accession>
    <name>A0ABY7DIQ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_028910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ96220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="105" mass="11971" checksum="1B57D1ED1866E6FD" modified="2025-10-08" version="1" fragment="single">VTENGSQPGPSNNTKVRAWKIPEDVTEVKQFFELCSYCRKYVKKICSITHRMFVISNGQINRQCEAKYKLVKKERLHLAAGHKANQKKTSTFVLLTKIVGNSILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJZ1</accession>
    <name>A0ABY7DJZ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MALT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_022382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052039">
        <property type="entry name" value="Caspase-related_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576">
        <property type="entry name" value="MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576:SF37">
        <property type="entry name" value="MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="116"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p20" evidence="1">
        <location>
            <begin position="428"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ98009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="619" mass="69546" checksum="26C6C24FB0A40386" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKB4</accession>
    <name>A0ABY7DKB4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="60" mass="7033" checksum="F6C764ABA3F59E40" modified="2025-10-08" version="1">MGWFALLKWWPFGDYIASGLPPLAVITLLLWGGLEIFAIWKRLSFKRRKQTGFTIDFQKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKT3</accession>
    <name>A0ABY7DKT3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L22, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_022176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ97803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="165" mass="18678" checksum="C98F2AAF86EB4851" modified="2025-10-08" version="1" fragment="single">MYWAASGSLYSASSSPHSRLCLPPPPGPSIPGLTMQRHLTRLLKRLPAGCQGQVYQGLHTSSVSLDRDRSSEDTKDFMGKILKNVYTTMTMHEKEICHKKVMIAVTPKKMWYPAFMVRGLSIDEAITQCEFSKKAAPKIIKDVLIEAQERAIKFFNVEYKSNLWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLL5</accession>
    <name>A0ABY7DLL5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">APMLA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_030181</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="402"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ97491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="507" mass="57312" checksum="E16E67876B33F521" modified="2025-10-08" version="1">MTGLFRKCGCYIVVGGLTGLGRVLVKYIAESGAGHIAIFSRRQPSDEQKQYFKDLETGCSCTIHTLQVDVTDLESLYLARQSVCFALNGVPIRGIFQGAGVLVDAIYENQTEETLVKVLKPKLDGTWNLHVSFKDLPLDYFVMHSSVTSLLGNPGQTNYAAANSFLDIYQLLLAVETGQPTATILTDIDLRAEIPAIANEVVRGINVIPLSAQPSNDMTFSEFLEENKKQMIADIEHGQLPYIDIVNFLQPENKASFGRHYLIMNDMTKLDMLASGTPDHPYTVSIKNIWLAKLSKETICQVVYNKTKQSITIHFHYNERLCGVERGRHFGEKLFQILHHGIRNRHQTIGTVFHKTDCFHGPKQMKQPDIANESHSSPAEKIQLSSPSKYRPRTHLNVQPMEIINGYFQKQTKAGWSHRVYVTLLEHQDNDNDAKWITIQWSKKPGRPTKSLSVSTCDSISMLNLNRQHSIVVQARERQLVICTPEHEVAQRWMTVLENSAKRPTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRW6</accession>
    <name>A0ABY7DRW6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HCD2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_010735</name>
        <name evidence="2" type="ORF">MAR_022073</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="238" mass="25110" checksum="189EEF33CEE37A4B" modified="2025-10-08" version="1" fragment="single">NTVSLVTGGASGLGRATAERFAQLGSRVAILDLPSSDGENVTSESDVSSVIDKISEKYGALHNVINCAGIGVARRTINFGRKETHSLELFNRVLLTNVGGTFNVIAKACPLINENKPLNEDNCLGCIINTSSIAAFDGQIGQVAYSASKGAIAAMTLPIARDLSIRGIRCVTIAPGLFKTPLLESLPAKVQKQLATLVPFPTRLGDPAEFAHLCQSIAENPMLNGEVIRLDGAIRMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSN6</accession>
    <name>A0ABY7DSN6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABCE1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_024456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd03237">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="264"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR00084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="541" mass="61232" checksum="61083ADB9047ADF5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DT82</accession>
    <name>A0ABY7DT82_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="446" mass="55074" checksum="2939827575188E0E" modified="2025-10-08" version="1" fragment="single">MKQCIITPNTRAYCIKRCIIIPSIRIIILHKAEHYHTEQTGILHKTVHYHTEHKDILHETVHYHTKHSGILHETVHYNTEHMGTLHETVHYHTEHMGTLHETVHYHTEHTGMVHETCIFKPNTRVYYMNQCIFKPNTRVYYMKQCIFKPNTRVYYIKQCIFKPNTRAYYMNQCIFKPNTRVYYMNQCIFKPNTRVYYMKQCIFKPNTRVYYMKQCIFIPNTRVYYMKQCIFIPNTRVYYIKQCIFIPNTRVYYMKQCIFIPNTRVYYIKQCIFIPNTRVYYMKQCIFIPNTRVYYMKRCIFIPNTRVYYMKQCIFIPNTRVYYMKQCIFIPNTRAYYMNQCIFKPNTRVYYIKQCIFKPNTRVYYIKQCIFIPNTRVYYMKQCIFKPNTRVYYMKQCIFKPNTRVYYIKQCIFKPDTRVYYMKQCIFKPNTRVYCIKQCIFIPNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTN2</accession>
    <name>A0ABY7DTN2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR01070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="260" mass="27374" checksum="8E655D1DBA9911F6" modified="2025-10-08" version="1">MPLCVVGSRMTLCVVGDRMTLCVVGGRMTLCVLGGRMTLCVVGGSMTLCVVGGRMSLCVVGGRMTQCGGRMPLCVVGGRMTLCVVGGRMTLCVVGGRMTLCVLGGRMTLCVVGGSMTLCVVGGRMSLCVVRGRITLCGGRMTLCAVGGRMTLCAVGGRKIMCVIGGRMTLCAVGGRMTLCAVGGRMKLCGRRSYDIVCDRRSYDTVCIGGRKIMCVIGGRMTLCAVGGRMTLYAVGGRMKLCGRRSYDIVCCWRSYDTVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVD5</accession>
    <name>A0ABY7DVD5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GCNT3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_008228</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297:SF191">
        <property type="entry name" value="PROTEIN XYLOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR01670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="284" mass="33316" checksum="F206137CEB03E471" modified="2025-10-08" version="1">MSKFVSFRTAVVNRHSGMLLSSDSKEMERAIDYLEGKNKQFAHFPSIQYDTMEKLAGRETPKAKGVQLPYGTEEDTDFPVAFYIPFHENVVQLQRLLYIIHRPQNIYCVHVDDKLSSKDFEAVYRIANCYKNVFLTSRREIMVYGSVTEIRAELNCMEDLVNSGHRWKYLIHFTAKSFPLMTNSELVEALKSHKGKNIFHSNWPEEHIQFKRRHILLCRSGHYVRNTCVFSVRDLATLTQRRELVANKFDIAYDPIVYMCMEQWITNKTRGNHLQGTKKSLRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DW18</accession>
    <name>A0ABY7DW18_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S13A2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_007652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF135">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR01094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="537" mass="58863" checksum="3631FF92321411FE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DY73</accession>
    <name>A0ABY7DY73_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_009231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR02673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="331" mass="36408" checksum="A3A972FFE7083949" modified="2025-10-08" version="1">MSGVIWAPLVGSGAVDREVLKRTARVTAGRYTSMLDIVQLLVKTGIAPEKVAAISRVEGLGQGNQGVFELRGGDFDFKLRNKQFKCLNLGKQFVNLRVHWLPNYIKDGVVETVFSRFEKKTFFGFNVETGVRLVRLSLSVDELKCLPHIVKFGCGQQCLVSAPGRPPLCLRCKGLGHMRRDCPGTDTNSGEFQASTPRMADGDVWNVEDEVETPVVRQQLAEVPPSPTVQATTTEVEEVTAPGQEQDHDVSDDGSERALMIVEEEEVKGVKRGADDTDDEEGGSFQFPPNKYMSRTTSDRVVGSVETDNRFGILGNEDGMQELIDTLTPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYW2</accession>
    <name>A0ABY7DYW2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_008767</name>
        <name evidence="12" type="ORF">MAR_008772</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR02209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR02214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="317" mass="35911" checksum="553DC923A5AA478B" modified="2025-10-08" version="1">MADTDKLNIDSIIARLLEVRGTRPGKNVQLTESEIRGLCLKSRELFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKETMGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKKKFPYGGLNAGRPVTPPRGTAKGKGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2P3</accession>
    <name>A0ABY7E2P3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="59" mass="6824" checksum="7C63EAA8EAC8D4D8" modified="2025-10-08" version="1">MQLPKRNSVTTYPPWERNDRYAIAQEKQCDYLPALGKKRQICNCPRETIQSAEVAAGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2R4</accession>
    <name>A0ABY7E2R4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TTLL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_009364</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin polyglutamylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF31">
        <property type="entry name" value="POLYGLUTAMYLASE COMPLEX SUBUNIT TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="345"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR02806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="391" mass="44852" checksum="660C24C32CEA01C8" modified="2025-10-08" version="1">MSGKQTVRLKYACDQDKSVLINNFEARGWIPVGADDDWNFYWANVQSIRSVFSVDSGYRLQDDQVVNHFPNHMELTRKDLMVKNIKRYRKELDKDNNPLAEKDETGRFVHLDFIPQTYMLPADYNLFVEEGIGIFLVNKLSQLKKWSRDSKTSNFVPPTSKDTYVISKYIDNPLLIGGKKFDLRLYVLVTSFRPLKCYMFKLGFCRFCTVKYNASMNELDNMFVHLTNVSIQKTGDDYNAVHGGKWTVQNLRLYLESTHGKEVTDKLFDEIDWQIVHSLKAVAGGISNDRHCYECYGYDIIIDDNLKPWLIEVNASPSLTSTTSSDRIMKYKLMNDVINIVIPPGEPPEYDEDLAQSDPITVDPKNKLGPGAMGARGIREPKGRPSPATWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2T4</accession>
    <name>A0ABY7E2T4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_019524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd14813">
        <property type="entry name" value="bZIP_BmCbz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031106">
        <property type="entry name" value="C/EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334:SF20">
        <property type="entry name" value="BASIC LEUCINE ZIPPER 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334">
        <property type="entry name" value="CCAAT/ENHANCER BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="259"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR04155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="326" mass="35574" checksum="6DD76B3563ED0D65" modified="2025-10-08" version="1">MLGEQEILCLSGAGEIVPNTLDELVDYLDIGGGQGEEFEEGKSHLNDPTRLLECTTFVQAGNETVAGKASKHFLYGDMEPGTGFALGTGDAGLEPGSADLGELLPLDMMEGDFLDSFLDLSNFLDMQDSDQAAVSAVNMGDVNGKLDFSGITSHLDTEPAVTITEIPTPSVGHALKKRKFVEYSEGDDADVDVITVKIDEGPVDLGPEVAEADHDYVVRKKQKLATIADFDPTAVEVIDSSASECRSAPVHVSTSGRGKDKYRERRDKNNEASRRSRQIRKNKFKDMDKEADELEHKNETLRKKIVELEAMAKTMKAMLIQKMTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2U4</accession>
    <name>A0ABY7E2U4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_010082</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="3"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="96"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="192"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR03524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="284" mass="31918" checksum="B6796FBE805965BF" modified="2025-10-08" version="1">MDRPENSSNRPKPIAPDPPKPTNKNTQLQLDERSGKSRRYTGPLNCIKVTVNEYGVRGLYRGLPVLLYGSIPKSAVRFGVFEELKRHAVDDKGNLSPSHRVLCGAGVAEAIFAVTPMETVKVKFINDQTLAKPKFRGFFHGVREIIRAEGFHGVYQGVVPTIIKQGSNQAIRFFVMESLKNWYREGDPNKKVPMYVVGAFGAFAGACSVYGNTPVDVVKTRLQGLEAHKYKGTLDCAYQIMKHEGPRAFYKGTVPRLSRVCIDVCITFMIYDTFMEMFNKVWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E589</accession>
    <name>A0ABY7E589_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_010526</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041249">
        <property type="entry name" value="HEPN_DZIP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049050">
        <property type="entry name" value="nSTAND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18738">
        <property type="entry name" value="HEPN_DZIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20720">
        <property type="entry name" value="nSTAND3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DZIP3-like HEPN" evidence="4">
        <location>
            <begin position="43"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Novel STAND NTPase 3" evidence="5">
        <location>
            <begin position="185"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1141"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1145"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1167"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR03968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1183" mass="134650" checksum="1E4A8701E4D40D50" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7G0</accession>
    <name>A0ABY7E7G0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="537" mass="61349" checksum="73E7FA6D9A8DF1D2" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7I3</accession>
    <name>A0ABY7E7I3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRI33-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_019753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR04384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="288" mass="32351" checksum="421444D518265BB0" modified="2025-10-08" version="1">MASKHGTSWKDSVSNAGDEIHDFSCSVCKDDNLNIEAEYFCGDCSKYYCDTCLTFHAKLLKHHVVLGRKDVDMWVGQGDALVACALHPPKVIELLCEDHDELCCHLCVSLNHRMCRSISLISDLAKGIHKMANFKQLPANVTKVTDRLNQVNEARKKNQNSLNTSGKSILTQIKNLRSSLNEMLDELEKMTVEQIDSVLADLDGSLQKDIDHCDLLHDQLKALLDTVQAQGKESSSYIGFKKCKDTMEEANRLLHEIENKQEATITFQPDTRAQQLLSDLKALGNIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7M3</accession>
    <name>A0ABY7E7M3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P4HA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_020573</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="7">
        <location>
            <begin position="341"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR05204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="535" mass="61370" checksum="07F942021D494DF2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7T4</accession>
    <name>A0ABY7E7T4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="232" mass="27059" checksum="5859E6BAE587B364" modified="2025-10-08" version="1">MYVFERFNSWICKRALNMRYPEATTIETFIIHDWCNFMMSTGRIPDVSNTETAEAVDLNDDANKADCSAIDDHNKTDKRRQLHQRNSDLRSIHNQLERTVCDSCVVYKYSYHTEIHSVTKRKTVFTSKMFETETAKTVSSFVCCEFSTVSNSVAERNCFAYVEGFENLQFDCDTHMWYSEIKSGNKRKCSFMKVNKLSNPLVTAEEKTESHVLWFLNSVCEQYDSTNLKDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E803</accession>
    <name>A0ABY7E803_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027197">
        <property type="entry name" value="SLC43A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20765:SF1">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOBASE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20765">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 43 MEMBER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="99" mass="11136" checksum="C1D98A907F8693A2" modified="2025-10-08" version="1">MKLSLSPNQAKTTQQTDGRYPLQTFPVLFGVLHSSAGLAGLLQYPLFEWYKSHQLAPDHVNYFMIGLAVASFIHPLYIWISCRRHGEKGGKSDAIEVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8G5</accession>
    <name>A0ABY7E8G5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38192" checksum="8574E4A628A6CAE0" modified="2025-10-08" version="1" fragment="single">TNFVYQSYSNLDRGPTDSDDYNLHDENEQLLETVVRYSSLATRKKPETLLLFGLSGSGKTSIVNTIFNELTGIPESALQAGSGSTQSKTLDFKYVNCGILQENIIDSDLQSKIGAIIGNLPNIIDCAGKGNVNDEQTKEILRHTLTGRIPPGTSIAALEELQNKKGVGCLNVVLPPCNPEWAVTKIIFVQSAADSIPEQLLDMLHDVLSEHDDQAGRDLYGSDQDATITAEDFQDKKDKLATALGIKNNVGDNCIPWASYSDTVRMPSPKVQNSVLKLLRQIQCPKPVEHTGVPLPRITLLQSWRLNLNAFFTTSSCRTYVLIFVICTLVAAFLWLIAKVHESPNTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9M1</accession>
    <name>A0ABY7E9M1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_021248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="196"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR05879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="429" mass="47687" checksum="40D9827E341F14CA" modified="2025-10-08" version="1" fragment="single">YPNGPPHLWAEEVLLEGETVNITCTSSNARPPPLLRFIVEDTEIDTNTKVSTTLNDSTGLYTSVSTLHSFKRAYGNRNMSCQQLPEVNGLYHETMSNSPPLLIIHVQEQRKLSKLIIASCSLMFVDSACNIKWESTIEHFKYTSIANNTFKQATTSKISFNVIPEDYGKQIRCSTECQYVRNALVNATTVIFEKKPKVVVYSNLVLPVPPLTTITLTCVANAHPVGNITWTMVETSYLKSSQTKTCSNASTCTYEMTTSDAEQVYSCNAKNEHGSDEGSIVVVHEHNYKEEPRQSGRGSFLWILLSGIAVVTLGIIVLVLCVFLYEGVNIRQDGHHTYQDIAVPSSNRPHELDATLSPGIYDEIDENNSSSVQAGTNLTTSATENRQCLIESSNPYSNISQRIPTGTQMTEMTRYFSESNNRGGIKLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAL6</accession>
    <name>A0ABY7EAL6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_021578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF9">
        <property type="entry name" value="CELL WALL INTEGRITY AND STRESS RESPONSE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR06209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="299" mass="32804" checksum="82DFB782D275769B" modified="2025-10-08" version="1">MIHVELRVERQPTTTTTTSSTTTTTTTTTTTPSTTTTSTTTTSPSTTTTSPSTTTTTSSTTMSSTTTTSPSTTTTSPSTTATAPSATSTDAITTTLIAETTESDTNTAAVSNERTVIIVVASTVGGVVLVGLVVFLLGLFLYRARRHGHGKHKHNHKRNTRRQQSGGEYIYSGQNNGHSMAMHPSMASYIDTRHGYPHSIKDNPDRHIRVDHHKQANGKHEGSQMRNTNNVKSRYSVYPGNMVPSRSTQNFFPDHFPRQDEWQRPATTGNIHPGHVNLALQSGYTYYQPRDYSDNWNMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEN2</accession>
    <name>A0ABY7EEN2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SYT12-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF252">
        <property type="entry name" value="SYNAPTOTAGMIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="80"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="172" mass="19767" checksum="B3FC5CD03F82C541" modified="2025-10-08" version="1">MFFVQQIVRTGGLGVDVMLYGRDIQRNTTDPVYKERFLFNIPSETLEERILQFQLFAIDKYQRHKVIGESDLRIGDKPTEFGDIMFSLSYLPTAERLTIVIVKARNLKWNAGKDTGDPFVKVYLLQNGKKVNKKKTTVKRGEQNPIFNEAMIFSVPSSALPYIEVLVITKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EH44</accession>
    <name>A0ABY7EH44_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DIAP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_017672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd16713">
        <property type="entry name" value="RING-HC_BIRC2_3_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046447765" evidence="6">
        <location>
            <begin position="20"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="460"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="620"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="556"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR07714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="667" mass="75982" checksum="99919AB6E31DBD15" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJ29</accession>
    <name>A0ABY7EJ29_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CSRN3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_035071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AXUD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031972">
        <property type="entry name" value="CSRNP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023260">
        <property type="entry name" value="Cys/Ser-rich_nuc_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580:SF9">
        <property type="entry name" value="AXIN1 UP-REGULATED 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580">
        <property type="entry name" value="TGF-BETA INDUCED APOPTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16019">
        <property type="entry name" value="CSRNP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02031">
        <property type="entry name" value="CYSSERRICHNP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cysteine/serine-rich nuclear protein N-terminal" evidence="9">
        <location>
            <begin position="28"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR09995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="579" mass="64614" checksum="7AC6F29BFDB2B2E2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJS6</accession>
    <name>A0ABY7EJS6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="277" mass="31341" checksum="3F908C87FB2ED484" modified="2025-10-08" version="1">MLAIRQEMFQCRIGNHKQKMYACNITTLVTSTPSPKHLGLGVHLYHEFNSRHLIEDMSALGYTITYPDLRMFLTSAAHQAITAQKVTPSGGIVPDNITSKQRGVADNWDHNERTGDGKRTTHAMTSILVSSTSVENRISQRLGKSSRRPFDKKCLPGEPEIESFCQAIATHVVRLLDEFREEGQKVSPTFQVWNNYLSRVSTPLKLLLASTRSPKLDSISTCKITAYASTVRFQSYNLCYVYVNSNSDYEQATDESRRGISCRSFHENGNTKIQRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENA8</accession>
    <name>A0ABY7ENA8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="117" mass="13849" checksum="C72AFFB9B7BED4A1" modified="2025-10-08" version="1">MIRWGAEDDICRTFARVNQHSDYCILNVKLSVEVNDERGRHWDTVILNMELNVEVNDERGRPWDTVILNMELDVEVNGERGRHWDTVILNMELDVEKLWFPIGTHPFLELQAEEMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENH7</accession>
    <name>A0ABY7ENH7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BBS4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_025737</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the BBS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44186">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44186:SF1">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="333"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="367"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR11557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="659" mass="72530" checksum="49003BA0C6F67117" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPG3</accession>
    <name>A0ABY7EPG3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047273402" evidence="1">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="78" mass="8377" checksum="2BA94DB2825C6E2E" modified="2025-10-08" version="1">MDAIKVFCFVFALVGVFAAVIRTCSLIKVGKNECKEGTQLGLKIKACACVKDLCNGTMRVTVTIFTLVTAVLAAFKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQT8</accession>
    <name>A0ABY7EQT8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">OXDD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_026390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="186"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR12210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="281" mass="30780" checksum="3CC92B7E2B3BD67C" modified="2025-10-08" version="1">MYDIAVIGAGVVGLSTAVNIQEVLPGRHVTVIADRFTTGTTSHGAAGIIRPTLEKTPVKDVDQFRKWSDDSFGWFHHLNVDLDPSQTGVQRLTGYQFNTDAESNTKYPFHHVIDYDFCELSDEELNRLPGNYRKMLSAGELCRNGGQNIVPGYGNVPRTRTSHPGKSSVVEALLRMGPWQQLHISGDSVVLGGTRQKGEEDVSEGEPWFTNILDACSKLVPGLKNAPIESKWIGLRPHRTYVVHNYGHGANGIFLSWGTAIEAAAITKDLATKGTLTKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQY7</accession>
    <name>A0ABY7EQY7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MRC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_025729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="51"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="189"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR11549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="354" mass="39642" checksum="5AD921584F45E964" modified="2025-10-08" version="1">MLRAPIRQTYSGKDVESPHQAVTQWSGCREPSAGRLTVVRMLRALSRQTNSGKDAESPHQALSRLTVTRETEDGFHGDNLKCSWQIVAPSNWRVKVTVTQLDLDWSSSYSTCDAYDRVNIWEGSNQEGEKLTAICVAWNPGTILSVGNSVFLQFSSTPRNAYQRRGVEMFFEIYDPSNCPPGWIPVPSSSSECLMVERNLTADWSRSQDICKFNKANLASLHSIDEMDALFLTGTGKGIFPAWIGLNDKDGNGQFTWIDRSDLSFQRSIVNQSYKNLCVAQGFDATDWLARECREKLPYICRGNKDGSSILYNEGNEPPPQEGTGYFMVSRCNCHRSGTSSVSPQHNWNILLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETY8</accession>
    <name>A0ABY7ETY8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">GPI alpha-1,4-mannosyltransferase I, catalytic subunit</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_026940</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 13">Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="392"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR12760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="462" mass="52920" checksum="5C6E56C74A6842AE" modified="2025-10-08" version="1">MNVYFFQMLPSKSFWIILVLGLGLRLGLLLYGEWQDRNMAVKFTDIDYHVFTDAARFVYQRATYRYTPLLAWLLQPNISVNPAFGKLAFIILDIFTGFLIYAITSSNGVSAKLSTFCSALWLLNPLPMTVSSRGNAESIMSALVLLTLKLLQDSKPFYSGTVFALAVHFKIYPVVYALPIYLFLGDRSISLSNVGWKERLKYLLPNMNRLCFICTAGLDIRHNFSPYFYMLYQQTATQQSTLLALLCFIPQVALMLVFSFKYYKEPALAFFLNTYAFVTFNKVCTSQYFLWYLCLLPLVLPLMARISKLKAAVTLGLWFAGQGLWLLPAYYLEFEGLNTFLYIWAAGLVFLFINCYIMYVIMDHYRPIKTQSDSSEAKDGYKYTQIVTQTRTTTKSSAKSKRQLNSTKKEDSSESHSEKMQSDGSKTMNTTQTKAVSPRKRTPKKVESPTLRYSTRTRSSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVF2</accession>
    <name>A0ABY7EVF2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RBL2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_027450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002720">
        <property type="entry name" value="RB_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002719">
        <property type="entry name" value="RB_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015030">
        <property type="entry name" value="RB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028309">
        <property type="entry name" value="RB_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13742:SF17">
        <property type="entry name" value="RE32990P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13742">
        <property type="entry name" value="RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01858">
        <property type="entry name" value="RB_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01857">
        <property type="entry name" value="RB_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01368">
        <property type="entry name" value="RB_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01369">
        <property type="entry name" value="Rb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retinoblastoma-associated protein A-box" evidence="2">
        <location>
            <begin position="78"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Retinoblastoma-associated protein C-terminal" evidence="3">
        <location>
            <begin position="605"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR13270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="733" mass="82529" checksum="8A2BF0891A001A7B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVJ5</accession>
    <name>A0ABY7EVJ5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="85" mass="10206" checksum="D6EB29D8AF2AD722" modified="2025-10-08" version="1">MDDIVEDRACLTVENYEAIAIIKTTLKKKKEKLTTMKDLWKKFTNKCSPQFECMRKCLRREREFKRKNHKLRIHATDSFQGPKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVL6</accession>
    <name>A0ABY7EVL6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EGH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027389">
        <property type="entry name" value="B_mannosylTrfase_Bre-3/Egh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779:SF1">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="207"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR14002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="494" mass="55601" checksum="2B37601DDE21EF24" modified="2025-10-08" version="1">MTRFAACGKISRAGTRFSEQVTSLFYAIGSSIKHVLACALLVFCIYLVNLLFGTQADQSHLRPLEWYGRFWCIILYTMRCIPYLSVPFAITNLLGIVTMNTFPRPPTLKVALAKIPFMCFRVVTRGSYPDLVRTNVERNIKTCYKIGLDNFKFEVVTDKALNLPKSSLVRELVVPNEYRTKNNSLFKARALHYCNEPAVNILSNDDWVIHLDEETLLTESSTIGLANFATQGEGDIGQGVISYANEEIVNWLTTLADSVRVSVDLGMMRFSFRKLGCPLMGFKGSYIIVRESVEKDIGFDFGPKGSVAEDVMFALIAWGKGYKFNFVEGEMWEKSPFTIGDYIKQRKRWFVGHVYTLLSSEIPLKCKLGMIPTDLGWFLLFGNILNLPLSIVFPVPLPVFMNVIAGSMGGTILFLFVFGSIKSFSIRKHGLFKKILLIFANVLIIPLAACLDAIASLYGYYTRDSGGFHIVLKETQKTQTDRNQQNAQLRLDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EW81</accession>
    <name>A0ABY7EW81_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="209" mass="22318" checksum="37C960FFE9E89CCB" modified="2025-10-08" version="1">MEMIANSIVADLKKEIKKSAGFTMNGRKFPINDQHFPTATTASGFEISFAKAVFGNVVQAANDSGLLHYKLGFKEIMANQKFSLNLSCSGIFCAGNVFYKNIVIPLQLRLENEQMHGKMGVSVSADICATAEKGCNASADTGYVGNATVGLLNFMDTLPVPTTTAPTTKSVNVGVQSSASISLIVVIVFAQLCLGFVARLEKYYKPGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWS3</accession>
    <name>A0ABY7EWS3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF1">
        <property type="entry name" value="AT07410P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="75"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="347" mass="39661" checksum="1BEC59AB3437149E" modified="2025-10-08" version="1">MGSISSWGLTDTQRAKTPTLTDQHAVPDIRIMDGEVNITLKMAEKKGISSLTDASIEKAFQKTNEECRRPDTELVRLRENQYEDAFTIIKNWDEPLGKSLNLQWSKERESSWRRTFDEGLSLMLLDSNNGEAIGIRIIKQDVKNEEIDPSKIQNDALRKIHTFIHQEVEKSRFYEKYGVEESFHFLGLAVSEKYQKKGHGKYLLEVGVEFVKNLGICPYIHGEGSSAYSQKIYEKIGFETLKEVAFEDYKVNGYKSTDKEDMDSSGLLSICINCRYIASVIANIRNFEQARDLRNTILHSGTFEFQDDEVQTFIAKMIDVLSDGDVLSKDVNALAATENLKKTWKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EY72</accession>
    <name>A0ABY7EY72_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">XRN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_003917</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 N-terminal" evidence="6">
        <location>
            <begin position="86"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="8">
        <location>
            <begin position="665"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="9">
        <location>
            <begin position="788"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR13812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="889" mass="102908" checksum="66A2D3C640C18F2E" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZL0</accession>
    <name>A0ABY7EZL0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="13220" checksum="88ACF15BB04695F0" modified="2025-10-08" version="1" fragment="single">MGLKHRGWSCDNWSDVLFSDESMFNVSVADGRRRVNGRRGERYAQCYVLEADRWEGDRAGISRDHKTELHVLRGRINAVNYMDIILQPIVISFMRAHRLRHLLQDNARPNVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3Z5</accession>
    <name>A0ABY7F3Z5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="98" mass="11071" checksum="C63D867D51C2F9C6" modified="2025-10-08" version="1">MPSRWNGTRLEEGTEEGSKATFIRNQAQRLHVQLGQAVSVQFLVQHWLVSPCSTLEERCIGWDSYSSGDLSTSGLLKKVSVIFGHRVFRTSDEDEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F432</accession>
    <name>A0ABY7F432_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPNA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052079">
        <property type="entry name" value="E3_ligase/Copine_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45751">
        <property type="entry name" value="COPINE FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45751:SF11">
        <property type="entry name" value="COPINE FAMILY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copine C-terminal" evidence="1">
        <location>
            <begin position="78"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="273" mass="30075" checksum="12DB4D1D71ACD5ED" modified="2025-10-08" version="1">MADDIHRPHHLLAARLTGEDKEVTDEGTFRTIVDRFNRLDEVTKAIQSVGVDQCGIIFGIDYTTSNETQGKNTFGGNSLHTVKEKTINPYQEVICVLGETLEPLDDDGIIPAYGFGDKGTPDRKLFPLKPENDCDGFMEVMDVYNHVTPGLKLGGPTNLAPLIDEAVHIYHILVIATTGQLACQAETVASIVTASNFPLSIIVVGVGDGPWDAMNDFDDLLPERIFDNFQFVNFHKVKQGARNPQASVALAALMEIPDQYMYIKDLKLVEKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4N6</accession>
    <name>A0ABY7F4N6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="entry name" value="Hypothetical protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046172763" evidence="1">
        <location>
            <begin position="18"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="125" mass="14073" checksum="FECAAA544C59BD8E" modified="2025-10-08" version="1">MKIVLLLTFAFLHVCTCREIVKKNAVIFEIEDSDESNIAYDDAESFDDEIDDSFDYDLEALQYPGDCKSSKLINFAEKGGCKVKKGKQKHITITKDNRLVTRIPHHVKSNGTCRSIIDALNANCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4P8</accession>
    <name>A0ABY7F4P8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mab-21-like HhH/H2TH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF69">
        <property type="entry name" value="MAB-21-LIKE HHH_H2TH-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="1">
        <location>
            <begin position="262"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="442" mass="51593" checksum="0356C8FC960A9725" modified="2025-10-08" version="1">MEDKPLSGKTRRRISDGELSVRVCEVLDQLGYSQSMVEHRREAWREANGIVNSTGQNPTILIAGSKAEGFTAPSESDTDRVFLDNYTMCRIPEDDSPTLSNTKCEFTMDKEHCHPGHFRLEQKEAGAYECLNIKQALFVHDNGRTFVSSEKYRTSYMQDKTKETISGPALTGCNEYYSWDFVYAFPCTSQQQLLAEWINRPRHHNWPTPDLIAEVPKLEAQMVPVGCKSSEHKDIEWRVCFIPSEQRLTNSWEENQYKIYILLKLIKKSQLKPISEEISSYVLKNIMLWYTEQNPRHIFQKEHLLQNVILCLKNLKEAINTNHLPYYMIPGRNLLTGKISLELKQQLIEKVKELIQEGPNVILRLPKVQAALKMSPAELAERGRWRDELEKLALERWNIWLTHWRPGMETEELPFPNKIDELAWQDPDYIRVDEKMNDMYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F595</accession>
    <name>A0ABY7F595_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="27270" checksum="222B20A1D72F9391" modified="2025-10-08" version="1">MATDTNTDFVKAHSAKLGEYVEAKSVIMKKQSNQQYMDIVQASFSLDSYAAHTLTHTQTHKLDVKQDLSGEVIPEGVEEEDMLLNFGDTNLYFLSNIRNAVMMFVPLLRFLPGHTDAIGSALTTARGKTLNTTLLHRRKPTSQESHVVSATCCLMLRKRRNTTWSLLSSTILLLLHHPEFQDRLAKELQAIAKQGEEVTSGDKVKSPLMEALELETNRLIVVILAPLARKARKDVEYKGYTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8N6</accession>
    <name>A0ABY7F8N6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_032581</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="209"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR17987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="402" mass="45860" checksum="A6BEB310EA6B7F13" modified="2025-10-08" version="1">MCEHECDQNCIKRGHGTRCSAKSGKCLHGCTSGYTADVCQNDPQGEKDTSFDSRADAIGGSVILIVAIIAVIAFIALRKRYGYKETSTCKTNQNDEEHVDSSNVYATVNKNRAAQTDAIYANTSDGSTQKVLVSNHYCKNPPGKKARTNMIEIQDCLEIDDEDAIAREIAIRFEEDGGVYYNNANEVNKTKVNVEALHAYVNEKTKRSFEEEFKKLPYGLTKSYEDSQKATNMSRNRYKGIYPYDDSRVKVWCNGTDYINASFIDGYKRRNEYIATLGPMSKQLGDFGLFWEMVWQQKVEKVVMVTNLIEEESSEERKLYQFHFTSWPDRGVPEDVLSLIEFWKMVLNSSKKLNGPTLEQYQFLHRALVHSLTLDCNPVKGKHYQQFVDNLRDSDKGELYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAA1</accession>
    <name>A0ABY7FAA1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_000931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR19093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="108" mass="12093" checksum="7CDFD90FC9CBFE2B" modified="2025-10-08" version="1">MENQKRKSDADDDTDNDATGQSNHSFSISIVGPHHNETYQRFKEDSLDLPVNGWAEMPEGQLQVDAVYGYIIALGVVLYSPGQDIKINERGLECECYSGTDIQIDERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FB00</accession>
    <name>A0ABY7FB00_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EYS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_000377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR18539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="98" mass="10373" checksum="C8CD051B7F05DEEE" modified="2025-10-08" version="1" fragment="single">MPEINECESSPCRNGGVCLDRVNSFTCNCPLGFAGVDCSDGNGPTCFSCAHLGMAETCTSITTCQSDEVCVTETYEKSDGSRRYDTGCRKANVCMSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDX3</accession>
    <name>A0ABY7FDX3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PKHH2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_000804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045188">
        <property type="entry name" value="Boi1/Boi2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF27">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="29"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR18966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="220" mass="24931" checksum="6679792BCF579842" modified="2025-10-08" version="1">MASEGTDSRTNSLTNRSSSSQHNDDDLQPQELKGWLMKRTKLSRKWKKQWFLLKSTSLLYGNSPEDTEKQIPLTNSEISESIIDKKQHAFCIKSKENGRSYYIQADNENLQNEWMQAICFAKAAGQRGDNSQACVIQFNGSLFLLFIGEPTSSLATGEMSSWTYSGRPHLHWRLERCPVGHIPVEPTSSLASGEMSSWPYSGRANIFTEDWGDVKLAIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FE60</accession>
    <name>A0ABY7FE60_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein quiver</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_032140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045150828" description="Protein quiver" evidence="3">
        <location>
            <begin position="26"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR17546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15383" checksum="8CA9CC20D1D80785" modified="2025-10-08" version="1">MATFLFGFGVLVGLLIVFSVNEVFGVKCFHCNTQVNKTCNDPFKKDSFEGKECPKGCMTQSGNDPDGYFVVNRACSDSIGTTCVDGELFNRPVHTCYCDTSLCNSDEHPPRSSAAGVANVIVVLRVLKWLYLHDVVFDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEZ0</accession>
    <name>A0ABY7FEZ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ISM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_001282</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051867">
        <property type="entry name" value="Angio_Inhib/Adhesion_GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10239:SF29">
        <property type="entry name" value="AMOP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10239">
        <property type="entry name" value="ISTHMIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03782">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="AMOP" evidence="5">
        <location>
            <begin position="35"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR19444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="205" mass="23210" checksum="1FF45932DC89DA73" modified="2025-10-08" version="1">MQNGNNVANTNTINEFYKWESDDFVPPLDRLEHNDLDIGSDVCGNWVECNSKFAQDFINNATLPGCPCIFPLIRVKTKHIFDVTLDTDVTWLDSSGHDDLVYKPGAKACMRSTLASGTTTLAVQQCCYDDTYMLVTRGRAAGTPMLISPEISEELHYKIDLLPWVICKGDWTRYNQVLPPNNDFRCAENPNEETLQFQKSLLSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFY4</accession>
    <name>A0ABY7FFY4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="538" mass="60193" checksum="8115A9535DE811BE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJT2</accession>
    <name>A0ABY7FJT2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAR14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_015271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF70">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Macro" evidence="7">
        <location>
            <begin position="514"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="832"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="832"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="859"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR21297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1162" mass="132922" checksum="A945EE9035D06309" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKD0</accession>
    <name>A0ABY7FKD0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MSD3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411">
        <property type="entry name" value="APONTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411:SF0">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="265" mass="30417" checksum="25928841CD7DB6C4" modified="2025-10-08" version="1">MPRLKGTVVFSAFEKEFFLALIKKNEKVIFRKANSTNEILEKEKVWTNLTTEYNCRKEVHPRTTQQLKVLWKNLKTRAKSDVAAIRGKHSETDRHANNVNQIGYYSEQVCSIVKTEPCSFSNDYNDDTNVHQDNTVVPEAKHEEFSDNGHVGTSIGSSNLGIINHPSEFLSQTSASSGHSFVSDLPVKSQPAKVIETPFHVFNPSAEIGILEKHEHDVKVKLLLEKHAYEMDSLKMKKRHEQELFEQQMKVMKLQEKEMICKLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKQ2</accession>
    <name>A0ABY7FKQ2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38967" checksum="B59C238CEE7D5EB2" modified="2025-10-08" version="1" fragment="single">MINRMASKHRTSLNDSVLNASDQIHDFSCSVSQSLFLNLNTEAKYFCGNCFKYFCDKCLTLHAKPLKEHSVMSRKDLDKWVGQGDALLTCGLHPSKVLELHCTDHAELCCNLCVSLNHRMCRSISLISDQASGIHKKADFKQLPAKVTKVLEILNNVGEAGKKNMNSLKASGKSILTKIKNLRKTLNKLLDEMEKKTVKEMDSVLAELNGSLQKDIDRCNNLHDHMKALLDTIPARGEDSESSSYIGYRKCQDKIAEVNSLLKQMSTRPEATITFKLNTQAEQLLSELKTLGYFEGYPDTQIPKKPAGVSLPREINKFSDISTVFEVQGKKYFSTKLISDKKPCRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLB2</accession>
    <name>A0ABY7FLB2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="164" mass="18596" checksum="25269D32CAA605BE" modified="2025-10-08" version="1" fragment="single">MYELPGDVDCPVASFEKYLRKLHLQTALAAYGSERLIASKLLDHFGTARHMVRVSGHKSEMSIRSYSRRLCADNQQQISDTLAKTLQKKPNVTSIYQQAPINPPNETATSWIDISDLDENAFIELEVIWKENHPQNVQSYVKDKPVVTQESTNIVLQPVTTIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FME8</accession>
    <name>A0ABY7FME8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045583567" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13079" checksum="62FFC3E37CCC2B84" modified="2025-10-08" version="1" fragment="single">MEMPWTKILVLIAAVADLATPTLTCEYIVESRRVSQRDIPPFRPLRQPNGTCDIPGRLRDRWTLLTPDRERLRIRAHSMTARTETSIGSHGSGVLCLGFAAIFGSDVVGEYSIVRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPT6</accession>
    <name>A0ABY7FPT6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TMM68-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22753:SF14">
        <property type="entry name" value="MONOACYLGLYCEROL_DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22753">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="155" mass="17874" checksum="B9478E20E5439912" modified="2025-10-08" version="1" fragment="single">VGWLIYPVILSFLLPLIIPIFLYCCAIFLHVYQYRQRLHEAYVHDFWDGAKKTVAVFWEAQGRIWHGYEAVGLERIPDEGPAMIIYYHGALPIDFYYVMAKCLLQKQRQIHAIGDNFLFSIPGFRLMMEVFCISPGTIHTCADILKDGHILGIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPZ6</accession>
    <name>A0ABY7FPZ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_037068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46901">
        <property type="entry name" value="GH04942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46901:SF2">
        <property type="entry name" value="GH04942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="3">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="3">
        <location>
            <begin position="159"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="2">
        <location>
            <begin position="314"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR23399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="620" mass="67659" checksum="0D3A7A7906E0E58D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQ56</accession>
    <name>A0ABY7FQ56_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">GPAT4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MAR_015300</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF2">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 4, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="16">
        <location>
            <begin position="131"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAR21326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="299" mass="34538" checksum="5AD8C3354790D874" modified="2025-10-08" version="1">MEQVLITLSLIAIIIICFILCLTIVLAALGKSLGVRRLYVETLLKVFEFGRKRIKSYAEMERHRPEQGEGDLDTAEGLPGEDSVPDTPTTPTTKTPDFDQVIHRDISISATEGITIPSKRSDYNLSWRREFNISDMMYFMKCGMECIIQDDVTQRFTAEELQSWNLLTRTDNGYQFIRMKRKLNSTFSLMSHRILCRAMSATVTFHNRMKEHVENEDKLPILIFPEGTCINNTSVMMFKKGGFEVTPIVYPVAIKYDSRFGDAFWNSSKESMVRHIYNIMTSWALVADVWYLPPMRRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQC9</accession>
    <name>A0ABY7FQC9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Large ribosomal subunit protein mL64</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">39S ribosomal protein L59, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Growth arrest and DNA damage-inducible proteins-interacting protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_036597</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mL64 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.120">
        <property type="entry name" value="Growth arrest and DNA-damage-inducible proteins-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018472">
        <property type="entry name" value="Ribosomal_mL64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043035">
        <property type="entry name" value="Ribosomal_mL64_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31761">
        <property type="entry name" value="GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEINS-INTERACTING PROTEIN 1 GADD45GIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31761:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10147">
        <property type="entry name" value="CR6_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR22928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="258" mass="30086" checksum="7C4D2267BE571955" modified="2025-10-08" version="1">MAAPMQCLTFKRLNISILSNLLKNVRIYRSLSATSQTSDTASKENDDYDELERQEVERRIAKLRDVSGLNKFEKARMNGVMPSINSNRKYLKSRSFYRKMYAAYGSTSGVKPGIMWPSKGELQDLQEIERDWTPSFQDMVKKLQQEKTSHMEEERLRIEDVQKNMEKMPDLIAEYKKKQLKAAEVETSKSEKIEKIQEEFRQKFGFSVDPDSPKFKMFRSTRIAEDMEKKKKEKKVTKKAAAEKMLQDMLETGSGAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQP7</accession>
    <name>A0ABY7FQP7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">OX1R-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_038214</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="72"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR24545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="299" mass="34213" checksum="E5640EC09D6D1619" modified="2025-10-08" version="1" fragment="single">MESSNSTNFIVNNSSLYTYSNNNNVDTQAKIEIVNISDEQLLKLVKEFIYPKIQHWIFLTLFLAVFVVGMTGNILVCYSAWCSRSLKTVTNIFLVNLAVADILVLLICLPATVITDVMQSWFLGIIMCKLSVYLQRVSVFVSVLTLTSISVERYLAICHPLRYHGSYFKTKPIIAVIWIVSLATPSVDFYNMILVHDMCGPRDENIEMEFNMFLVVVFFFIPLVIMSYTYGKIAKESAIEYLQVRRRTAKMLIVVVITYTNALDGLRGNRVAVLCMYWTARFLCYFNSAVNPVIYNFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRS8</accession>
    <name>A0ABY7FRS8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TMM8B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_037265</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021910">
        <property type="entry name" value="NGX6/PGAP6/MYMK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14319">
        <property type="entry name" value="FIVE-SPAN TRANSMEMBRANE PROTEIN M83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14319:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12036">
        <property type="entry name" value="DUF3522"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046094101" evidence="10">
        <location>
            <begin position="22"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="592"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="681"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="709"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="511"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="228"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR23596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="790" mass="87913" checksum="4F67CC43432BA60F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTL1</accession>
    <name>A0ABY7FTL1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="342" mass="37871" checksum="D4A34F87A72DC8E9" modified="2025-10-08" version="1">MCCPCGSAWSQKLSTCVRTKHPLSDCRFRKDETRLPIECTLVPGPTPNTFYMSAMGDSNLFHCSDQMVFDEEKCTCVRDENFTWPECPPNFLQFSDPPLISRAVSSSGPSLWTIWNDVDFNGGQSISTDAGDVETGVNVAEFGLDDDQYINLVFSAHGGYGRSGSLCFWSLLNGNNTNADLDNNEEALFTNCRPDAGANFSPDHVQDDNTLRISVERNDNQYPVAVNVYVRLYSDSSRNPWNFEEKSLSCALSNTEVDEWFQVCLIWSGQYNAIRLVCKSNDDSMDEDSAETSGFGIVASKSGLIEGNDLTEANGLDPLFGKLALVEFYKGCLPDGLCVIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FV74</accession>
    <name>A0ABY7FV74_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR26047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="118" mass="13351" checksum="8865F34F3AFDE55C" modified="2025-10-08" version="1">MASLFRSSLHNASHLIDDFICSPCEEDELNSEAQYFCVDCSKYYCSCCESEHGGLFKRHKLLDRKDVKKWAAVPVTAVDDLVRCVHHHGKAVELICGDHQELCCHICVSVVHRQCSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWB8</accession>
    <name>A0ABY7FWB8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FOXE1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_011153</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="89"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="89"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR25449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="395" mass="43856" checksum="6160758766E36703" modified="2025-10-08" version="1">MNSELHDARGTYGAEVAPAVGGGHTNDPCDHGSTSISSTGSNEDMFDSSTSSEDQQRHVPDDVNNNENVNHDEGARRSRKRKRPVASGKPPYSYIALISMAIANSPDRKCSLNDIYKFITDRFPYYADHGNQKGWRGSIRHNLALNDCFVKLGRRPGAKGHDWGIHPDYEDMFDHGSFLRRRYRFKNGVKRERGTRTIPDTLANPQFGFGSALDNSHPMFGGSCDYMQSSLQRTGDHQPSSQRPLATLTDNANAYAAWPYQFMTGYIHPNHTHVLPGRNEEPLSPISAHEMSFANSDCASSPEAMNQTCAPTYFRSISPVSTTGPVQQSGHMMPLSTERPEQPVEQYVPPPPPYPLYMWPNYGGLGSSNSPPDVKPGSLYQTQQYYGQGMWGSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWU8</accession>
    <name>A0ABY7FWU8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CA194-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022179">
        <property type="entry name" value="CFAP276"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12494">
        <property type="entry name" value="DUF3695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="151" mass="17464" checksum="F1D66E3F4DECB053" modified="2025-10-08" version="1" fragment="single">KFPYGEPTHIAQRQDPWKRLNAKCTLASSRREIYHNDPRAPNDSLDFVLKSQYNHHDKFLNAKNETLYQPETYTEDHGRVLKNRVKEVIIAPPEMNHPLEVATQKKKESIHSIKNAIESHHTQTTNRGYSRKPDESPHSAGTNGGYSRKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXE4</accession>
    <name>A0ABY7FXE4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P20D2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="1">
        <location>
            <begin position="108"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="327" mass="35078" checksum="2E4E0D32DA563489" modified="2025-10-08" version="1">MGTERSYKLETAFKATYGSRADGPNVTFISEYDALPEIGHACGHNLIAEVGVTVLGTPAEEGGGGKVKMIDAGAFSEVDVAMMSHPFPVNGIKPNALAVEIIEAVYMGRASHAAGYPWEGINALDAAVTCYQGISCLRQQCKPDWRIHCVILEGGVKVNVIPERTKLHIAIRTPTDPEMNTLRGKIMNIVQSGALVTGCTVETSTITKYSSMLHNNTLADLYAGNLAIVQTESAPWDSGTPPGSTDMGDVSHVVPSIHPMFYIGGTAVNHTRNFTADCGNPKAQTFAIYQAKTLAMTGVDVLLNKGLMEKIQDEFQNSMKKEKDGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXU1</accession>
    <name>A0ABY7FXU1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_011678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046526385" description="CUB domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR25974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="44793" checksum="B4B7BB9456B1D6F6" modified="2025-10-08" version="1">MSGNGSRVTMMHVPVLVLFLVSDILANDRTCNSNNIVTYWMDDDDIVVVSGKTSDEQSYKECNIKLGPATNSQKKMVRMKIQTYYNQDCGVFLSAQQSPAAFFDHEVKLMFNYSCSLRPGNDLTFYSDAGNNIKIKLQKTDNKHQVVQVTNIKVIIGVAVALFVVSLLAGGMIWYLCHRNRRWSRILKQSVPSSGRESPISARYSDFPLHEVHPSSSLHSQTCIVGSVTADGTCTVCNRQHDDFAHVIDIGPDGHVRGTHSRASNRQADTDTLADNQTSTPNLQGSRGQHFTHGSHPSNNHRREARLVRHPGDEYSDTHVAIATTNGSRGSGDIHDVGVDDDEMDISGNDLIPPSYDLSPPSYDEAVNMPMPDHDCSQGAGQAHGDTEIDPLYQNIDHSPRDSSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FY81</accession>
    <name>A0ABY7FY81_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone-lysine N-methyltransferase</fullName>
            <ecNumber evidence="12">2.1.1.355</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MAR_012316</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">MELC-2E11</strain>
            <tissue evidence="18">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60276"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.355"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.355" evidence="12"/>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd10542">
        <property type="entry name" value="SET_SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011381">
        <property type="entry name" value="H3-K9_MeTrfase_SUV39H1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009343">
        <property type="entry name" value="SUV39_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="9 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="58"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-SET" evidence="16">
        <location>
            <begin position="268"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="15">
        <location>
            <begin position="331"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="17">
        <location>
            <begin position="555"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="477"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR009343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WAR26612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="571" mass="63436" checksum="2D7B3CA183E5C36F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G213</accession>
    <name>A0ABY7G213_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">KRH1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_013133</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="105"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="169"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR27429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="390" mass="43609" checksum="5F53164877BF84E7" modified="2025-10-08" version="1" fragment="single">MRLRREDPGGSSPEDSTEYKTAVKSVIWCEIKSLLQKLAAVTGEESIVISTNLTEGTYSHLGSFLGQEYLDDREDHILSLCTSFSQFCSGLQNHAVVLQEPETVFKENEREGPSPGPQMNPRKRPLTPDTGTHTHHHKRKSTHPHSLHGKSDQTAHFDKCFMNQSRSADIDSVNQSENPVLSGFYDSDNYPRYKQRKNPVKKSKTKDKATSLLGLEESPSTPTNSTKDNLHMRTFESGGRLVYACDVCKRELSHLTSYRRHMKLHTMERPHKCPVCLKGFIRKYHCIDHLNKHHKGVEFCPESLLLTGASRELYGGPVNTDQSALSDSHSISPGEFNYTLDQSLEASSDPDQSVNADISIDQSASSILSELARSAAKENIQVKEASNLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4F4</accession>
    <name>A0ABY7G4F4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallothionein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="16993" checksum="5C6BB1D79DA3D026" modified="2025-10-08" version="1">MKGSVVLLASMNVPCLKTDIASLPLQISSPEPPERATPSPPHPPHPKGSGCQCAHNHALYTCACCDVGGCQCQAPNSNQCVKCGDTKSCGHPLAAPDNGVDGYTTAINDCECKFDPSQSNCGCCREGMGACQCGRTHRNQCVACDHMDQCGNKPWIFGPPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4J9</accession>
    <name>A0ABY7G4J9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Y0266-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_002933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053108">
        <property type="entry name" value="Chlamydial_TARP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36975">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36975:SF5">
        <property type="entry name" value="TRANSLOCATED ACTIN-RECRUITING PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="751"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="806"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="918"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="417"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="592"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="609"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="640"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="658"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="674"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="705"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="751"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="832"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="918"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="958"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="971"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR29365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="986" mass="106059" checksum="D472F3CFE7838287" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4W0</accession>
    <name>A0ABY7G4W0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="187"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="319" mass="37008" checksum="78279413980D1B65" modified="2025-10-08" version="1">MPVTVEAKHEPEQFLKDNILKVACPDKKWYDDDIEYVKWVGVVKEGRQPLTIVTLRQDDDKMRVFTGRSSLRPDNIRIGNDLTKKQRLKLNALRSQGQKTYYYKGELKFVDKSYTHQTKQSERVIKTAVRQTSNIPLNANLEANEHDTHNQEMDMDTIVITYAQPVPDKPDLTKWEEGCLSELKVIQLFPDWREILCLLFADDLALMADTVVCLQRILNKLSDFTQEFNLRVNTKKTKVMVYKNGGTLSKTENKERLEVVNGFPYIFDTKIAPILAYCSELWGTEKRNTIECVQIYACKRHMCVPQKKNKHSTSNEILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5H6</accession>
    <name>A0ABY7G5H6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MEGF6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_003263</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="294"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="331"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="364"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="583"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="618"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="698"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="773"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="832"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="895"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="999"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="1126"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="1158"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="1190"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="1256"/>
            <end position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR29695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1440" mass="156337" checksum="3047A9F9554922A9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G614</accession>
    <name>A0ABY7G614_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="108" mass="12268" checksum="40BADA0F9C8A3A26" modified="2025-10-08" version="1" fragment="single">VGFKKISTQYEFEGRPDVVRLISANSMTKIKVILNCRMERTSILTGDVISEPASFHSNIEINLEGTDRVVIGSSKISLVWRYIQSSINHCEVILIFHFPTSLNQKRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G768</accession>
    <name>A0ABY7G768_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">COCA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_003553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF84">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046526393" evidence="2">
        <location>
            <begin position="43"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="69"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR29985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="219" mass="24478" checksum="4C3036965D4B53ED" modified="2025-10-08" version="1">MARFGASIKSAFLRNSGIYPPTMLRNFLVALVGLTAARGVQAAATTPAPIQFYTRYQKNTTMSNEKQLDFVSRFAQTFDIGPRNVEIGIVTFAATPHNEFNLNTYSTKHDLVAAIHKVGYHTGGTRTDLALKYVEANSFTEAAGDRAGVANILIVMTDGKSNVPAETVKESAHIHSNLNAKKKEEKKKKKKKKKKKKKKKKKKKKKKKKRKNKKNKNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7L2</accession>
    <name>A0ABY7G7L2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABCF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_032954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="178"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR30412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="283" mass="32237" checksum="8A129BDD7E6EF2A3" modified="2025-10-08" version="1">MPKKNKGKKREDDDWKDEEAEQKLEERMKDLKTGDQPEKKTKKSKDKKSKLKELAEFLADDDGEEETKPEPEEEIKPKEKGKKKTGKVPVRKPSPEPEEEDEEMDRDMVGKISDNDEDDENGEKDDTVKPKLSKKELKKLKKQMEYQKELDNLDPNSIHQFSVENFSISARGKDLFVNANLYITAGRRYGLVGPNGHGKTTLLKHIAGRALNIPPNIDVLYCEQEVVADDTPSLETVLRADTKRTALLEEEKKLMKESEAGNTKNSERLNQGLVSRADFIDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G895</accession>
    <name>A0ABY7G895_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">XYLK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_033182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024869">
        <property type="entry name" value="FAM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009581">
        <property type="entry name" value="FAM20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450">
        <property type="entry name" value="DENTIN MATRIX PROTEIN 4 PROTEIN FAM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450:SF14">
        <property type="entry name" value="GLYCOSAMINOGLYCAN XYLOSYLKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06702">
        <property type="entry name" value="Fam20C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045150846" evidence="6">
        <location>
            <begin position="28"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="FAM20 C-terminal" evidence="7">
        <location>
            <begin position="186"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR30640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="323" mass="37280" checksum="4AAD646431BAB021" modified="2025-10-08" version="1">MRINGRLALLRTVHGLLLCMIIRIAQLYPVHKAGISDQHLESFLPFLAEQNNYQGKDWRNITLFREELVKSLTSRYKIDWGCRLNKSPWSVAEKWLSNQTIIPERTPELGTQLKLLLKLKGGQKVAFKPKRFSRDAIIQGPPYAGEDRHNGEIVAFHLSRLLEFRRTPLAAGRVINLETEIKPGESTGVCGEGALLEGSLILWLPEGVSLTQHKHPWARTYKTGLLAHYHWGPRLLDIIDTAILDFLMGNADRHRYETYRDTMLMLDNAKSFGNPQHDETSILAPLYHCCRTEYWVVFYGKFSGETLYLRCYPIYIYVPWIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GB22</accession>
    <name>A0ABY7GB22_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4773 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_033669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031941">
        <property type="entry name" value="DUF4773"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15998">
        <property type="entry name" value="DUF4773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045150848" description="DUF4773 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4773" evidence="2">
        <location>
            <begin position="15"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR31127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="124" mass="13844" checksum="5E001291585F8B07" modified="2025-10-08" version="1">MQCGQSFVFHMLVLLTIATVACITVDWNSATDAYSVVLSVNGRTLYHTITNMPSSTMETCVPATRMDVKGEICFRFYNFDQGTGNLCASLEAEIEIEDLKEIIAINYGCFRIGTRPELTQNRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GCF6</accession>
    <name>A0ABY7GCF6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Glutamine synthetase</fullName>
            <ecNumber evidence="2 9">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_033589</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="2 9"/>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="10">
        <location>
            <begin position="28"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="11">
        <location>
            <begin position="115"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR31047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="365" mass="40978" checksum="B5E51589FD756544" modified="2025-10-08" version="1">MTAQEYSGRLDKGVLNHYMTLECPGDKVQCEYVWIDGTGQGIRSKCKTLDFEPKDPSECPVWNYDGSSTYQAEGSNSDMYLRPCAIFNDPFRRGKHKLVLCDVYKYNNEPAETNKRCTCKKVMEEAKSEIPWFGIEQEYTLLSHDGHPFGWPKNGFPGPQGPYYCGVGANRVYGRDIVEAHYRACLYAGVKIAGCNAEVMPAQWEYQVGPCEGISMGDHLWLARYLLERVAEDFGVVVTLDPKPMPGDWNGAGAHCNFSTQKMREKGGIKEIEKAIDRMSSQHRRHITAYDPNEGEDNKRRLTGLHETSSIEDFSAGVANRGASIRIPRQVAADGFGYLEDRRPSSNCDPYAVTEVIIQTAVLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GDR3</accession>
    <name>A0ABY7GDR3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_033653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="257" mass="28734" checksum="27893EA86045275D" modified="2025-10-08" version="1">MYFQYLKEFCVKFRDNSIFLCMDDKAIVPVGEPGISISTGVRGHNNVLAPAEGHARLTCTDHDFHVGGLVPYGVLATDIPVGPRDSLFNGTIQNTKYLAHQNHFAMRLGEVLSILRQNISQNDVDLEVPVLCFYTEGGPDHRVTYDTVNLSLVTLTAPNHSWTNPAERCMSILNLELQHVALDRGEMEEKIEKMLRNKSSLSAVQNQARLSDGLKDGFTKGIEPVFTKVNKRFAKMSLKSNTIVRHNGAKDDDMPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GEB3</accession>
    <name>A0ABY7GEB3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="10">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_033833</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="10"/>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1960">
        <property type="entry name" value="QSOX sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040986">
        <property type="entry name" value="QSOX_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042568">
        <property type="entry name" value="QSOX_FAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041269">
        <property type="entry name" value="QSOX_Trx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039798">
        <property type="entry name" value="Sulfhydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897">
        <property type="entry name" value="QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897:SF8">
        <property type="entry name" value="SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18371">
        <property type="entry name" value="FAD_SOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18108">
        <property type="entry name" value="QSOX_Trx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045150851" description="Sulfhydryl oxidase" evidence="11">
        <location>
            <begin position="28"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="15"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="12">
        <location>
            <begin position="342"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR31291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="610" mass="70471" checksum="9CCF1882F35FD115" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GGZ7</accession>
    <name>A0ABY7GGZ7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Caspase family p10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1470">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052039">
        <property type="entry name" value="Caspase-related_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576:SF41">
        <property type="entry name" value="CASPASE 14, APOPTOSIS-RELATED CYSTEINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576">
        <property type="entry name" value="MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p10" evidence="2">
        <location>
            <begin position="180"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR30431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="316" mass="36921" checksum="C7C0E95CB823E167" modified="2025-10-08" version="1">MHDKLDLVSILERVRCRNEKMKIIHRMPRKFFLSDELESIETNNMSYFDINGIIRCCFFGSKHFDDADADDLHGIEKDRAHVHEMSNEFVYTSYPLDNDRKAKEAFKFQLTKKEDTGCHMFVFSSHGDSEGLFTSQTDNKVKFIDLIKIVRALEKNLPVVLVFDCCRIENKGYFGKSLSVSNKLLQMRNIIVVYAAVEGYTSTMFEATGSVLIKTMFEVIEKHRLKSDFLTMMECVNRKICEPCENDFTGWNLQTCVEIDSQLEKKLFLFETETATINANEQEQKGKLIKSLHKRRRSPSMHRQQDNKKLRLKHQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D8P0</accession>
    <name>A0ABY7D8P0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_006507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="171"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ94036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="367" mass="40329" checksum="B65F1A54315CD187" modified="2025-10-08" version="1">MYVYSRTTEGVGSSGCGGGSGSERYKADKVKEVPPESPVTKCPINAAQSAMGPMDADGFVDLKRAVKVLPPDSPVTEFPINAAQSAMGPMDADGFVDLKRAGRGGNQQPQVNLAGGLPKADFELGKSQLQPSQYQVVQPHLQNQHGLQPVPQGEIRRFKPDGDRYEDRAHYITIKELGAGSFGTVDLCVDSDSQQQFVRKKLKKASFNPTEVSVPVKVPHENMTHVFGIISNPDNFGSARTPQESLKFVGMTPEYLAPEIAKLVLQLRFKAENFNYGLSEKDVTGKVDVFAFALVIMYIYKGYHILQKLITKGQTSYANILPEQQQLLQTQLLVQLASDNTFITNLIPDECSLDMRDLISDLGWNDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D962</accession>
    <name>A0ABY7D962_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SVP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="12148" checksum="EA6076A1CED4D347" modified="2025-10-08" version="1">MGLDTLNGLDTLNGLDTLNELDTLNGLDTLNGLDKLNGLDTLKGLDTLNGLDTLKKLDTLNGLDTLNGLDTLNGLDTLNELDTLNGLDKLNGLDTLNGPDTMKGLDALKGLDKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D9A3</accession>
    <name>A0ABY7D9A3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CP3AV-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_006693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ94222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="461" mass="53014" checksum="8E6580A78507E196" modified="2025-10-08" version="1">MHWGAKRKIVTTEQSTINELTAENLSLDNVRIREETKKIKLQMDLLLEQKNALISVKEMADAAKRLVIPTFQPVHPEVPYAEISYHWRNEQGPLTRGIEGSVLVSSINWSSYLCHIILVGFFTTSVWFEFVRNDFSGMGPYLQKCLDVFHEILDKKSQENPEGFDIDPVVRGYTIDVTCITGFGTEVSAQTDPNNPFNRHAKVALTFKPATSPMFLLYVFFPDVVGAFPKLFPMDFVPKDSLDFFIDASKSFIDERKKGHSKYKDLLQLMVNAHQDDEDDKTPNENRTQGLTDTEVIANSIMFMLAGFDTTASSIAWVLYDLALNPDVQEKLIEAIDEEIGENKLSYDNVFNMRYMDMVMSETLRIHPPAQRLNREASEDIEIKGLKIQKGMDCTYCPTILHFVEEYWDEPNKFNPERYRCPLRRHLAASTNLRSQFTCDWKEGSDVNPEISNMMKKRRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DC60</accession>
    <name>A0ABY7DC60_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C1q" evidence="1">
        <location>
            <begin position="29"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="135" mass="15274" checksum="DA89A80527BD50E0" modified="2025-10-08" version="1">MKYLMAENKDLRRSVEDLQQAMRIPHKRSIPESPVAFSAKLSHNVEHAGIDQTVIFDSVFRVPVEGIYLFNMMFADGYEPHRLWMRIVVDGQEKVAGVADTLTNNHDMMGGNLAILHLHPGDSVWVATFYAADYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDG0</accession>
    <name>A0ABY7DDG0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWA3A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_028024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46478">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46478:SF1">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="172"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="493"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="875"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ95334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1097" mass="124831" checksum="702358230C6820D7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDN7</accession>
    <name>A0ABY7DDN7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SNED1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_007202</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046683287" evidence="5">
        <location>
            <begin position="26"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="123"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="182"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="219"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="303"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ94731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="432" mass="48391" checksum="CFCAA6849D375AEE" modified="2025-10-08" version="1">MQNRNENIFLVSIFLLFCEINYCCADRAATWDACGCSWHDWKSWSSCTATCGGGKQERIRWVRFNDKPGCNGFEDCATNDSGWDNRICNANCENGGTIKTYGSTSAYCRCKTGTKGKCCEQIVTCGSPSTISHGTYTGTSFSYNRKITYHCNSDYNMTNPWRAVRTCSQWGYWTGSLPTCEYAVSCNSNPCKNGGICTNMLGTYRCSCSKGWTGRNCETDIQPPIYDHCPTNKAILVTTMTTNQTWTEPVFTDPHGFGIEISKNYQNSSFEFPWGKFAIQYIATKPSNGMTKECTFWITVTPHQCKPLQAPKHGAIACNGWKEQYARVCKFYCYSGYDLPPGFKPDTVINCGATGKWMPSNPFSECILMNLLPSARDVVTPKFNNCLAEKTSIAETYIRDLKRSQFNALCVDNLDFCNDRNVSITCTKAPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DE46</accession>
    <name>A0ABY7DE46_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_007367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF14">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="232"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ94896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="876" mass="99535" checksum="0FFD86BAF953711A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DEC3</accession>
    <name>A0ABY7DEC3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GBP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_007442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1000.10">
        <property type="entry name" value="Guanylate-binding protein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003191">
        <property type="entry name" value="Guanylate-bd/ATL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02841">
        <property type="entry name" value="GBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate-binding protein N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate-binding protein/Atlastin C-terminal" evidence="4">
        <location>
            <begin position="166"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ94971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="514" mass="60448" checksum="69203083B26BF961" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DF40</accession>
    <name>A0ABY7DF40_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_028967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="2">
        <location>
            <begin position="452"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ96277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="660" mass="74379" checksum="D2C36BF82B3C6169" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGQ0</accession>
    <name>A0ABY7DGQ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_028803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ96113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="122" mass="13143" checksum="63236DC5F8333D76" modified="2025-10-08" version="1">MLVYMYTAVPVDALLCSQCMSNATGSCALRAPDATPCQPRDHSDAGPANCMVARQIDRNGTVQSYIRGCSQVRVGTGCLPYPNGTSLCYRTCSEDGCNLAMAHDNFPSLYCAVLVFIYICLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DH83</accession>
    <name>A0ABY7DH83_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_028370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF25">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="108"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ95680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="384" mass="43554" checksum="EE6F88A9CCAAAB7E" modified="2025-10-08" version="1">MSSSNRKLKANFFAGGGEITASPESDSGLMSCEGPGICDQVNMVCQAFCDVYLTLKNGVCKKWAEQGSVKGKENMERFMSNEYTYPTPNDDCDETLPSTSTETLGKVCVDLAGELVTLRKEKQSIEEELNSVIDEKDVLNDSVEQYESSIEKQRKQLKRTSNRESYWRSKYQKIEKDNDKEHIEDDMISLQLNIENLEHGNRMKDNLIDDLNERPHELENQNIEQNKLNNCEFFYEKSKTYSLDLHACVYSLLDNHVALENVGDSNKLPSVGTIHNWSIERGIIAKQQIAESSNEHNTTLHTDEASKYGNKWGAFASRDQQGNYTLLGLKEMATKSSHDTLETLKDILNHIDDVTDDGTGNKLLVNIKNTKSDRTSTETKFNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DK37</accession>
    <name>A0ABY7DK37_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DCXR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_029757</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051737">
        <property type="entry name" value="L-xylulose/Carbonyl_redctase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44252">
        <property type="entry name" value="D-ERYTHRULOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44252:SF3">
        <property type="entry name" value="D-ERYTHRULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ97067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="243" mass="26042" checksum="DBE44113CA637AC4" modified="2025-10-08" version="1">MEINFKGKNAVVTGAGKGIGRDVAKRLAALGAHVVAISRTQADLDSLKTEVPSIETVAVDLADWAAARTAVAAIPNVDMLVNNAGTNRLDKFLDVKEEDLDLVMDINFKAVFNVAQVVSRQMVDRKSGGAIVNVSSAASYRGLLDHAVYCASKAAVDKLTNVMALELGQYKIRVNSVNPTVALTELGKIAWSDPVKADPMLARIPMGRFLDVVLIGNFFAVRRFSEGYNGRKFRLPGAGGVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DK62</accession>
    <name>A0ABY7DK62_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_022457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ98084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="129" mass="14319" checksum="B1615A8CD18E8F00" modified="2025-10-08" version="1" fragment="single">TNECLSYPCKNGAICSDLNLRIHITDKRFKGATDVHHGAKHDCMRRDKYSNSRKMPGWKLHFLSSHWTRTLTHMELLADFVMTMCRALLPIPRVSSTNGEVGGKCFADGSCNGEAICAGYFCECGDGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLQ1</accession>
    <name>A0ABY7DLQ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TF3A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_022999</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054599">
        <property type="entry name" value="TFIIIA_Zfn-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF20">
        <property type="entry name" value="TRANSCRIPTION FACTOR 3A PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22110">
        <property type="entry name" value="TFIIIA_zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="158"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ98626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="374" mass="43630" checksum="F4DE50A8772C88A1" modified="2025-10-08" version="1">MDVKRFTCKFPDCLKQFSKQSRMMVHQRSHTGERPYVCDVEDCLKTFKRVDHLRRHTYTSHRDNKTDNFRFQCDESDCEASFSSIDNLTKHVRVTHEKSSYRCHITGCGKEFRKHHQLRTHRLEDHQGTAYKCTHADCGKTFQMSSHLKRHLKTHEGYVCSDLECGEKFDKWSLLVKHRKVKHLAARVHQCCKCKKSFSQKQWLKQHMMVHETSRAVLICPHEDCGREYLDQRNLNAHVRSYHEGKKFNCEEQDCGRSFATKKKSRPKKKAAEKLTGVSTITMETEVRGQDHVTFKSPIRDEHVHPPHLHMETISDTSDLDIPDFEEINSNEKETLKVNDLGAIETILTPENIHNSAVKQKESLQTSVENKAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLW7</accession>
    <name>A0ABY7DLW7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MYCB2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="364" mass="39816" checksum="0660A1E5F92D0A79" modified="2025-10-08" version="1">MDVILHEGKLANIEADVIVNSANQRLALKHGRISASILKTSGDGLQEECSRLYPNGIHFGGVAATNGHGLKCQRILCDVVSNCLNQADKEKMTSIAFPTLGCGFLNYPADIVMESISSCVSKFETEHKQTTLTKCGHACTGYKDEAVCPPCLQAACASRAVGLSQTADDDCAICYTEALRDAPVIQAQISHTKLAPILAPLEALLEDVKRKALMRLAYEEQDKADHQNPELYAMEKYSYYQCFKCKKCEGAAADKEIQEEELVCPPCSDPQRVQQCVKHGVDFIEYKCRYCCSVASFFCFGTTHFCNLCHNMPHNMAALQPLPRCPAAPQGKQLQGDCPLGIKHPATGEEFCLGCGLCSNLQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DN51</accession>
    <name>A0ABY7DN51_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_029115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="115"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ96425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="310" mass="35410" checksum="74D5B0C7E5BB554A" modified="2025-10-08" version="1">MTGIALKDQATMNEEQRSSAKELDTWIEQLNECKQLSENQVKTLCEKEVKCPVTVSGDVHGQFHDLMELFKIGGSSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYKDRITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHSNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPAPRRGEPHVTRRTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPE1</accession>
    <name>A0ABY7DPE1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FREM2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="165" mass="18106" checksum="61A452BC75521F6F" modified="2025-10-08" version="1" fragment="single">TVYGRLDVSPIQLLDQNVYLYIEKVFVCAGQEGYIPLYNPDIGGCVGNPEQLDTVIRILDITDPSSVNTTFQGFPLSAMMSQDDTEFTEVFNIPGADGFSFDSSPLFKEDHIKRSLDDIAGVGNGEKGTNMAPLILNFNGKSLTEDQYKPGKRTENSESQMPLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQX4</accession>
    <name>A0ABY7DQX4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HS12B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_023364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd10229">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ98991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="624" mass="70478" checksum="0BCE344C925DF6FE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRE7</accession>
    <name>A0ABY7DRE7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HMMR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_024051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.510">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031794">
        <property type="entry name" value="HMMR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026203">
        <property type="entry name" value="IHABP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18956">
        <property type="entry name" value="HYALURONAN MEDIATED MOTILITY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18956:SF6">
        <property type="entry name" value="HYALURONAN MEDIATED MOTILITY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15908">
        <property type="entry name" value="HMMR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15905">
        <property type="entry name" value="HMMR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan-mediated motility receptor C-terminal" evidence="6">
        <location>
            <begin position="877"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="35"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="252"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="368"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="520"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="730"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ99678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1085" mass="125039" checksum="D764CBCCE07FF173" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTC5</accession>
    <name>A0ABY7DTC5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="173" mass="19170" checksum="7176A54CE8349B14" modified="2025-10-08" version="1">MSSFEHHATVDNKGLKMKIKRKNVNVDKTEKQKKDISTKSDLKSDSCKDQTETTGQSANGMFTEKAGKLSLFSDKEKSPKSKSSANKKDKSKVTTKGELSTQGPSSLNGIDNSFNQSAKSMEPKLGETAMGKKDCMPDPYEFNAKVEDDISMPIKKMKVDKEKLTLTFWLAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUQ7</accession>
    <name>A0ABY7DUQ7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_025191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="6"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF8">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="405"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR00819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="612" mass="67498" checksum="CD0D2744013EBA0A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DV64</accession>
    <name>A0ABY7DV64_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35378:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35378">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="136" mass="15312" checksum="B9FD57BF5700A598" modified="2025-10-08" version="1">MSLTLKPSEISSHKFKNGRQIGQVLDDICEGRISVSSFPLISVMKRDGRWTTSDNRRLWVFRELERLGKLDEIAVVQVYSIHDKKLTTINGGVSVKVRGTGPGGIWHNRLASTASLSTYLRSWRDMFDSSDSLDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVH4</accession>
    <name>A0ABY7DVH4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="97" mass="10801" checksum="D191A7C96D2D8B00" modified="2025-10-08" version="1">MVSETGFTSNIETDDNSNALSEELETADVKTEEPEEEEAEEELAVQGPINREPFEKIYGKRPSGIPLGPYLGTLQRIVTQSSDLLPMKRLIQHSVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYB4</accession>
    <name>A0ABY7DYB4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_008188</name>
        <name evidence="12" type="ORF">MAR_008214</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd22209">
        <property type="entry name" value="EMC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397">
        <property type="entry name" value="CHROMATIN COMPLEXES SUBUNIT BAP18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045034245" description="ER membrane protein complex subunit 10" evidence="10">
        <location>
            <begin position="23"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR01630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR01656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="168" mass="18818" checksum="C799A001B1DC2BDE" modified="2025-10-08" version="1">MAAPMENMIVLTVLAFISLTAGFEDEFEGSRTLSLEHSFDQGLDPVFTKRGTLVIKSVQSKRATFSQSAPLSKDDRQLLRSTVDDDGMYRVRIPIRETEEGTVYVSSFTRASYIEKLKREEQEKTKGGKSDDRSFFAKYWMYIVPFVIIMFVMQSMDPNQGGGGGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1I8</accession>
    <name>A0ABY7E1I8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-glucosidase</fullName>
            <ecNumber evidence="2">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_009380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="2"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1484"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1488"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="933"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="1411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR02822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1536" mass="174809" checksum="37EFC14D25630E48" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1W7</accession>
    <name>A0ABY7E1W7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynamin-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Scaffold protein Tuba</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_009762</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd07589">
        <property type="entry name" value="BAR_DNMBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="282"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="346"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="419"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="573"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="693"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="1107"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="domain" description="BAR" evidence="12">
        <location>
            <begin position="1319"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="1766"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="501"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="779"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="913"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="973"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1082"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1667"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1719"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="792"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="805"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="838"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="926"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="981"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1724"/>
            <end position="1741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR03204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1862" mass="209096" checksum="0DC59DD42AD0E21E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1X9</accession>
    <name>A0ABY7E1X9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="767" mass="87671" checksum="3BDC454F9E6F78FE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1Y3</accession>
    <name>A0ABY7E1Y3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RBTN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_009523</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050945">
        <property type="entry name" value="LMO_RBTN_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787">
        <property type="entry name" value="LD11652P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787:SF1">
        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="22"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR02965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="159" mass="18177" checksum="6E671060B6AE3647" modified="2025-10-08" version="1">MQLPQQQEGGPGQGGGVGQKQQECSGCKKDIRDRHLLKALDQYWHEDCLKCSCCDCRLGYCSACSKMIPAFEMVMRAKNNVYHLECFACQMCNHRFFLCDNKILCEYDYEERMVFANMTYNYNALSQIKRQTNSLSDDLSSGYGSPSPGSTIYYKAVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E258</accession>
    <name>A0ABY7E258_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RAD9A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_007814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rad9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026584">
        <property type="entry name" value="Rad9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009303">
        <property type="entry name" value="Cell_cycle_RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR01256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="509" mass="56067" checksum="36A24A393D06558E" modified="2025-10-08" version="1">MKCIIPGTNIKVFGRGIHSLSKIGEELYLEPLEHGLALRTVNSSRSAYACFLFAPSFFIHYDDGAGDASSDDSEDTLRCKIAMKSILTVFRSLSTMEKTVERCKIKLNMKESRLVFQLYCRHGIVKTHNLAFIECETLQAVFSKDMSPNSLTASSKLLCDAVMNFQNNQEEITLIVNPEKIVIKNYVDDEPDPNKVMHTNLSLEPDEFDNCQVGVDTEAILGFAEVTTLPLTINFETAGRPIVFTIDSDSTFEGNFVLATLADQQGQSQAQTQPRQATQKRSNIDSARSNEVNADYTDFMNDDTDFDIMIQNDTTVVYPRQTSVDTDKHTHTLRVKEAGALETHTDRSEGSVARQTNTDRSEGSVARQTNTDRDKGVVARQMHTDRVEGGGAISSASRGGIRRVGGKGDNQSKSGRFNSPIVNNSVPSDDEESPVLPMLGTKVKIGDTTLTEDMVVDNADEDEDVVPGTPPAKRFRSLFFGSSQASQSQSRNPDLCTSRVLAPDSDDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2P6</accession>
    <name>A0ABY7E2P6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ZNF76-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_010037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="468"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="498"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="528"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="558"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="588"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="618"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="648"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR03479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="865" mass="93589" checksum="46AB94E144AA6544" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E305</accession>
    <name>A0ABY7E305_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">SC5A7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_019599</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd11474">
        <property type="entry name" value="SLC5sbd_CHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052244">
        <property type="entry name" value="Choline_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897:SF4">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="460"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR04230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="547" mass="58948" checksum="6C115CE3E72185CC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E389</accession>
    <name>A0ABY7E389_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="412" mass="47905" checksum="91367535430D3075" modified="2025-10-08" version="1" fragment="single">MVKKVVLTEKGNKNELIQEMVHIFTAQWQTKQFKQNKANIPAGSVLQVMDFANKRQIKYQMKSRDFFTNRQVTMHPKKIIEELKKRIIFSDGCSAQYKSKGPFADFANERTEINRNYFGSEHGKSECDVEIGLLNRSLGKAIIGNKAVLNSAEDVCNYCHSDLEVDDVPSTRNFIYVKYERWIETDPKLIDKNSQFPPEIEQYKRTRFVKEKQLQQNEVTVVKTEANVANPAVPKFNSEEIHGSKSQENLESTVSYPLTYSRQDYFLMILSKMCLCESFGNLQIILATIEDEVRELYGDIHFNPDLGMGLQLIDWHIRQPFNNRTVEAHWANNNYEDRNCLPRSGSILSFEDEDHHAEIRCRIAIEMVTNIDLYLSDEHLQNGEFLLEKEARHLVKTCAMFSEHYRKLVKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E431</accession>
    <name>A0ABY7E431_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="91" mass="10186" checksum="C95A3C6736450D24" modified="2025-10-08" version="1">MSTMDCKEDNVITYIIHNLEVRRKKKLPMYLVLTLVPQNSVVVGPQYGDFFKTKCVYADAGIDIFCKTDTGIDPVSVSFSVGGKSLVRDQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E549</accession>
    <name>A0ABY7E549_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="120" mass="12975" checksum="D8801C2D86F8916D" modified="2025-10-08" version="1">MDGSETLSGIMLWRGITLGLRTIAGGEKMQELKLGVLTVVYLVVLCLIQLGAADQNGQSSNVLKENTKIALRKVCEQLCFEESANCPNECQMAILQPLVSSDDIPSYDKRASRGIDGLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5C7</accession>
    <name>A0ABY7E5C7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="131"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="242" mass="26220" checksum="4E13EA75D92895DE" modified="2025-10-08" version="1" fragment="single">HGQVQLNTNGAITAVLGNNTYQLTCTHSGLTESQIQLLSLKLVKDGVHLVVIPPFSFSGANVTVNATMSSRMSVVRFTANNPTTTVTFQFTKCGDEGTYTWVGFYYDPTSGASQVSQTQDITVKALPGFEPVDSVLSYTPNTNIAVGDKVTFTCSGDVGNNPVGVLAWFYFREGEVTPVDESSNAVSTAPQVSRKCSRSRSSTLELTLTRDMYNMVVRCTVQQDRRTSDGEGHITALYKTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5E9</accession>
    <name>A0ABY7E5E9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PPCS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="170" mass="19596" checksum="5F5F482284A0AD2E" modified="2025-10-08" version="1" fragment="single">RYFLDQGYAVIFLHRARSLQPFARHLPQTHLLDILQIQPDGCLQVREEESQKIAKVVERYHSVMREGRLLLPEHKIQSSNGPLQLSLELVPKMLEALVKHWLQEAYIVSFKLVIGNILTTRKHSVVMVTQNGEESIQLNSGEITAGVEIETKIVENIVTRYNKFCEEQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9L7</accession>
    <name>A0ABY7E9L7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30917" checksum="DEA081C2BB6AE357" modified="2025-10-08" version="1">MEYPYINMYEANCPSNNPDVTVYYITVYYITVCYTFIQCFKVGAYTFCGASPVRLAYTQVSIYCTKLHTHANNDDIRMFKCTHVPCYAEKNGRALTTVCVALGFLLYLDHRLPQLFNSFSLTSLCYREVLKTDYGFADMLKIHATLPLLCQVSLCLSSIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIINSIISISIVVVAVVVIVVIVIITFIIIIIIIIIIISISIGSSRSSVAIIIILLLFILILFLQTRFLSALFDMIITTPVSNCML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9V8</accession>
    <name>A0ABY7E9V8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HMCN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_021139</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052598">
        <property type="entry name" value="IgSF_CEA-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337:SF20">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="87"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="183"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR05770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="271" mass="29085" checksum="BB356AFBE755A134" modified="2025-10-08" version="1" fragment="single">MAFNSTGDSIALREGDRFSSIACVADCKPSCTFRWTKGQTSVSTSAVLDLGVVSRDDQGEYTCTATHSVYTVFTDTKPYPITVIYGPDTVSLSPPSTIYTKSEHDPLGEIFCSAVCTPECAYTWSKDDTSETLRNNAILNLGQLSRQEAGSYICTATNPSSSATRNGSTVVVEVISSKIRDGPDAVTLNVPSVYSVSEEATVSNIECSADCWPGCVFTWTNVTGSQLISSSNVLVFGRADRYDAGDYSCLAKNSANQLSGEAEKHFTLRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EC86</accession>
    <name>A0ABY7EC86_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DRD2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_017585</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF224">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="59"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="249"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR07627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="442" mass="50530" checksum="B38C7B65E3460233" modified="2025-10-08" version="1">MSETSGHHFATMNTTPPCNVDKNRTCYDTAIMELNRTFVELMWPVIFMMTVFMFVGAFGNSVVLFMYARKRQGTTHVFILLLAGIDWLACLVIHPYVLYKLFNNYDQTWNITCKIFEFFIHVTLAVSGLTLLLVAIDRYLAICHPVRYLVFDRHVTKGISAISVISILFSLPLFEFYGAAPNDTVYQGTMVKTFQCHYQVKYQTSAVLMGFGAFVMFIFLSEVIAMVFLYKNVAVTAYRRRKSVMPLSNVPSLGGTKPTSGSKSRLPFNPNLTRSLSSHTSPVQLSPASLSPDAQQDKSIIFSVTNHAFQPGKSQDRLYGTLNVESRLQANQGVTNMKLQDIAQTNRLNKSLNFSSRLKAAKILFLVTAVYFLSWMPFFVLRLAYILNRNFWDDDSDTKKVMELLLNHIFYLNNAANPIIYTMINQTFRQECKQLFIRHLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EC90</accession>
    <name>A0ABY7EC90_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_021786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046289750" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="30"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR06417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="143" mass="15686" checksum="530CEE334D10624A" modified="2025-10-08" version="1" fragment="single">MCGTAVMSSLHLRITFVVVIVCRIYNGADGSVTISSSAATVPEGSSLTLTCTYTGNDQLYAIKWTNNGNNSTQRYDIQINQHEPCSIFGKPGLNETLFTYTCFTLTILKVTREYQNDNFTCGVNINIYSGNSVIVSVSGKRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEJ6</accession>
    <name>A0ABY7EEJ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DIAP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="405" mass="44651" checksum="DB14BD512A87F846" modified="2025-10-08" version="1">MASGYNKNERQQKADTINPIPISLGISTLKPKFQQYALPSKRYESFTESSVPWPLTSPVKVEDLVAAELATVSVATTAAVVSGTGRQGTTRWNSTPSGTRPANTSSSPREKHYIHSVEAGENPDKMPRRSKGSIVKQTPAEDSASLKQAAAEFGYSKDNINIAACIFRKRHGADLVTILMEMEDDPDLAFNADVSDSSSSNPVDKCFEYKDDNNLQSLIEENQRLKDSRNCKICLDNRADVIFLPCGHIVSCPPVFPRPLPESTDESADDRISNVAKEVGCAISLADIDRSHRLGKPKAGALQSSANRPRDVVVKFVSYRARSIFMRSKSKLKDTNFKGVFINEHLTPLRSDIFYLAMQLVKKRAIDIALTFDGTIKIKISTGRVIRIENQGDLDKCKHSTNNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGL2</accession>
    <name>A0ABY7EGL2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NDUF4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009622">
        <property type="entry name" value="NDUFAF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13338:SF4">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13338">
        <property type="entry name" value="UPF0240 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06784">
        <property type="entry name" value="UPF0240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="279" mass="31527" checksum="1C67C585CE9599CB" modified="2025-10-08" version="1">MKLPADDTVEVAATEDTDEAPEVAAAAADDDNDDEVDLTGSESCTFLPVGSAVTAVCCWTGLRRGTSSESMEIFRRVPSPMLPWRRGQFGDQIVSLLAQKAIEKQKTEPKPAPRHQSTDKMFEKQSTAHPEVREEVEKQDPRLIGRVNELKLEMEYDMPRICSSADRPLPSNRKNFEDPDDAFINVKKIPKGKMSLVQAHTILERHLEDQQKNSAVALAKEYNLDIDNTLNFLRFYSRMNVDVQKAPQKTDSLIEIESITKKKTRSVTKFIDTLFQKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJB5</accession>
    <name>A0ABY7EJB5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="221" mass="24783" checksum="F9DF2DBDAE690FE4" modified="2025-10-08" version="1" fragment="single">MVTKGYTDKKKKTRAERNSFERCSKTTVAQLKTTKRKTFFSPAKCPIIVSLQEMTPILSPMKSPFRSPLYKASPPKKRAKKSTSARILFEQTDCSISPEHQKNNISFPELDILELDYDTAIDKTVHFLETIVESSPASINEEVKSLPNRKRQTQEGSIESEKLEICDTAFKCRTVSIKNSDKSNLEHNTDIAEGVPRITVTTNKETALDKSTSTSTESGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJZ2</accession>
    <name>A0ABY7EJZ2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PR5K-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_035394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045622721" evidence="2">
        <location>
            <begin position="16"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR10318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="204" mass="21335" checksum="DE3FB537DB60F351" modified="2025-10-08" version="1">MFTLVLFTLVAGTLANHQLHVHNRCGYEVWVGILGNPLPDGAAGASHTTTVTNHWSGRFWGRTHCSGNHCQTGNCGHGPQCSGAGGAPPATLAEITFDAGGSNNQDFYDISLVDGYNLPMSMQPINGYSGSPTSRYCARAGCNSDLNHSCPPESDGGGEVSLVIETDGGREGRGQVSLVVETDGGMEGRGQAEGRRDTDRAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EK50</accession>
    <name>A0ABY7EK50_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cryptochrome-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_018981</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF17">
        <property type="entry name" value="CRYPTOCHROME-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="12">
        <location>
            <begin position="20"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="12">
        <location>
            <begin position="520"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR09023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1072" mass="123429" checksum="BE93CE8C1D15B7ED" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELK3</accession>
    <name>A0ABY7ELK3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="135" mass="14220" checksum="6CE34D5D8A7F4E27" modified="2025-10-08" version="1" fragment="single">IGTSRQIARAVLSSPPGNIDAKLVKESDGDEKNCGKKRQQPASSKGKGQKKQKTLAVKTRKSPRKRIQEEEGGASGTEGGQSEISDAESMASRASQASKSSQSKPTSSSKSKSSSASASRRAVDVPIEEITQDQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELX7</accession>
    <name>A0ABY7ELX7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CDK14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_035083</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF189">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="49"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR10007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="387" mass="43841" checksum="E50686705883DAAA" modified="2025-10-08" version="1">MLDDKQYDSSGESRSGRPRSEGHKYNHSFCKKRASSYAGNPPFGRADSYQKLEQLGEGSYATVYKGLVSLTDQIVALKEIRINTEEGVPFTAIREASLLKGLKHANIVTLHDIIHTKETLTFVFEFVNTDLSQYLEKHPGGLNTYNVKLFLYQLLRGLAYCHQRRILHRDLKPQNLLISESGELKLADFGLARAKSIPSHTYSHEVVTLWYRPPDVLLGSTNYSTSLDMWGVGCIFTEMLSGVATFPGMKDAYDQLDQIFRILGTPTEETWEGVTKFPQYDKKKFVVYSKQGVSMVIPKLSYLPHAEDLVNDFLQMDPKKRISAREAMTHDYFCDLPPKIHELPAASSIFNIPGLKVYPEMDDMIQATSASPGKPVRRSRIRTTFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMG0</accession>
    <name>A0ABY7EMG0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HMCT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_034894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF393">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFD" evidence="3">
        <location>
            <begin position="133"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR09818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="236" mass="26218" checksum="4D4FE63E3FF30CAC" modified="2025-10-08" version="1">MSMIEYVFEAVVTIKFLHFFHRTINFSTCLDARWACAAKTIPIPTTNICKPNQEFSSCISSCPMTCENMHDSISCNTTTCVEGCICKPGYVKEGNDCVLKADCPCYHGSKAYKEGENTCRSRMWVCEQKDCPAVCSAYGDSHYTTFDGRSFEFQGSCDYVFAKSSETSPVKFEITTENIPCGTTGVTCTKSISFSIGEQGTFQINVKYLSSEFIYDPILQTVGVFLLNILVSVCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EML5</accession>
    <name>A0ABY7EML5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TSP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_036309</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF116">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047391105" evidence="4">
        <location>
            <begin position="24"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="154"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR11233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="293" mass="33126" checksum="DB8FFC2A65227E81" modified="2025-10-08" version="1">MDTPVIRIAILIVNVLLSNMASAEEPKCYSRFDYDEKMIEKMIRAEIKLEEFAKRMDLNDATLGDIRTDFRNEIQSTKEDISMNLNDFIEKYVANTTDGGWSDWTSWNRCPVTCGISMVTRSRSCDNPTPRMFGRQCVGNDQEWKTCEVQKCPGHTEKIAFYATITADIFPTKANIPLKFTHVVTNVGGGYEPTTGYFTAPTDGLFVFSLTVRQYGYSSYGYEGQFSIKKGDTVVMKVYPDMHSKNNEYDTASGTAVLELSKEDTVYVVADDSGKAIIGIEEFSSYFSGYRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMZ2</accession>
    <name>A0ABY7EMZ2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_035420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="62"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="313"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR10344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="384" mass="44299" checksum="03CEF046A9FFD4A4" modified="2025-10-08" version="1">MASKQIQCEMCCKENAVGYCETCGYVGESCIDIHKTGKVFQTHNVSMNEENNENPKVILRDITEERCKQHPTERAIFLCNVHDSMICGRCLHSEHLSCGKDVVDLLHEGVTIDCEKVKNMKSVLMEVKDEIQLVREDAEHSNDNNKKSADKCVMACMELGNQIKQRVDELTSGIRDEIRKKYDENLSTFSRITITCNETSTWCENEKRKIDEFVDNNMAGYLYLTCRKFEKGVSEVRSRLSEIKHKHTFKGFDFKENKVILKCVFEDLGEACKQEEVTESEDGSTNNVIVATTDIKKTRQELTVLLRQAIHFLDKSEKTRKALCDELKNVKQHLDNSEKARRAFEQELLKGKQGIEHSERARQKLCDELKQVKQELDSSEKVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7END0</accession>
    <name>A0ABY7END0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAMP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_035312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="181"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR10236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="225" mass="24412" checksum="61CCB35C1145A63B" modified="2025-10-08" version="1">MSGNENSGDGEFDDVINAEDILHVIELDDNRDISEVMEEADLGEDFDDDMEASGGQIEVQDMAGVVFDKHKDAVFSVHIDPNTSQLAVTGGQDDTAHDGTYVATADLSGLVKVWKIETKEDVFTFECSDAEWMKWHPGSHVLFLGTVDGDIWMWKIPSGECKTLQSHGCTVSCGVILSDGVNAHKSTVLCVDTHPVNNVILSGSTDVTARAYNSSTGKREKEAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPW1</accession>
    <name>A0ABY7EPW1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="345" mass="38766" checksum="561DF49A71149090" modified="2025-10-08" version="1">MSSTPLGDFRRFELSQAGEHLFNPWSFPILKSTTMPADQKLYGLPGPQNSAVLMDIISKLKQDLHQSRLENSKLVDQLNCLIALVKRAWGMEAPNFSVSDFNRNTPIPDKVFNGLHKMGDNERLLYRPREHFDDPNRYKQGNLFDPNVIFSPEMMGNKKRPSSASESSIGGGYGVRTGSRARSGSAVFLTEEKPNRPLKYETTRPISGKRRPLSGNPATRGRIKSAPARRAVPPTVVRKDLHSKSAHDFGDDGSTEQNDELQDIGRRNSTEYNISENDFDLRSDGVESQSEVVEDKPPMAVRVKKGHPMDKFVEDLRMVSEMEETFKKTALQLQKKLGLETSGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQJ3</accession>
    <name>A0ABY7EQJ3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TSP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_036308</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF116">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045229326" evidence="4">
        <location>
            <begin position="24"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="155"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR11232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="294" mass="32878" checksum="F687A3C9F63E77CD" modified="2025-10-08" version="1">MDTPVTRNAVLILYILLPNRATAEEPKCYSRFDYDEKMIEKMIRAEIKLEEFAKRMDLNDAAVSDLKTDFRNEIQLTKEDVATDLNDFIQKYVSNTTDGGWSDWSSWNTCPITCGVSMVTRSRSCDNPAPRVFGRQCLGNDQEWKTCEVLKCQAKSMEKIAFYASIKVDIDGTTANKPFVFNNVITNVGGGYDPSTGVFTARTDGIFVFSLTVRQWSSSSKGNEGHFSIKKGDTVVMKVYPDMHNRDNEFDSASGTTVLELRKGDTVYVVADDSGNYIEGSEALSTFFSGYLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ER35</accession>
    <name>A0ABY7ER35_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR10879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="127" mass="13887" checksum="8927B2660CDBEEEC" modified="2025-10-08" version="1" fragment="single">VDAVLDDYHRGSDPANHPSVSSYKKLLEHTATPPTDGCVFGEKPKAHVVHFEIKPLQEPQISTAQNQDPVTAANSTQNDVVADADDNSRCNKFNSCWKKFAFLFAIGGIVVPFAGLVVTIVYIAFVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERJ6</accession>
    <name>A0ABY7ERJ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CTU2B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_025757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR11577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="333" mass="36520" checksum="866C83F71A782509" modified="2025-10-08" version="1">MCSIQDGDVPLEKPKCWPEVSEMQERTSCTDNTGQRCILQGLSQRAHKKLRQPSKCDKEDLESHVISKDNQPLRVDSGLGSQLRQLLDSVKSVSGKEDLIQTLRHQMLYEAARHCGYSKVMLGSCGTRLAVRLLTDISTGRGMHAAMECGNVGASIEHLTESFVTGLQAEYLSTVSNIMRTGEKLDSTPESSSENSCALCQGILDTDVGVSSALSALEFSRQISTGKNAIVKKGGNSCGKSDIKGDNSSSTVECCGEGDGSCQSPSCDQVTSRLCYGCRIVANEMEDINTFPDFVFDTVSRQARRKYFKKEEAFYAIVNRFMLQHLSIKVNMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERQ7</accession>
    <name>A0ABY7ERQ7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LAT2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_025817</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF528">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN JHI-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR11637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="528" mass="57965" checksum="14960063015A17B9" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ES72</accession>
    <name>A0ABY7ES72_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_025836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="2">
        <location>
            <begin position="165"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR11656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="383" mass="44269" checksum="B84A4BC7061045E2" modified="2025-10-08" version="1">MAKLEAQLADMEGEQKKALKRKIKKTRRERGKLQHKMDMKMVLPGDKIDMSDDRELFALTKIKSKKQLETVEEVELSDADEEDEEEDVSNKKKKRIIFDREEKDYGMSDVSDEDEEFDEDDASDGSISLDEANDEENPLLVGKQSKKSKTDMWFSKESFAGLDDEDDEDVEIEKMAEAYQKKGGVIKVVPVDKNPPIKLNAQGLALGTAIVSSRKRKREVIESGYHRYMFNDDNLPDWFAKDEQRHHRVMLPVTKGEIQEYKMKMKAVDANPIRKIAEAKARRRRWREEKARKKADTINDTEEVTDREKWSQIKQVYKKAGLLSKKKKEVTYVVSKRGLAGKKTARPNGVKGPYKVVDGRLKKDIKGKMRAEQRKKGKGKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVH5</accession>
    <name>A0ABY7EVH5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CO6A6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd01472">
        <property type="entry name" value="vWA_collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="189"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="386"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="592"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR12954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="969" mass="102900" checksum="1AE11BDF531D0B04" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EW54</accession>
    <name>A0ABY7EW54_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="389" mass="46176" checksum="8D07DFBBB50C78CB" modified="2025-10-08" version="1">MAEPDQFQESRYSLRVNLRQKSEKIPERPKKSAKDYYEEYRKRLKSETARLQEARLYEEKKYRRSLTGEKKKSYNEKSKLRMRAYRQRLKTKASVDKPSTRHKVAKLREYWRLKKREERGSLTVFPKPSRQKESENNNDIKLAYIAIPGVYEHYDACVESLPTQEVFTATKFHDATCDETECHHIEDEQIPEVQLPSNKINSKTITTPKKKAKKLLTRKRKATPHNWKKNVRKQLRLSGEQYTTSEGKRQQLFESFWALGNYERQKDYVCARIDEVNTRTYLDDEGKAKSKRKQVARKFSLEVDDTRHQICKSFFMKTFCAYIDHAMKSKKGGHFTGKDLRGKHDPHNKLDIEQITYAKRHIETFPKVSGHYVRKETNRQFLGPELTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWC9</accession>
    <name>A0ABY7EWC9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="143" mass="16266" checksum="7D43602D095B661A" modified="2025-10-08" version="1" fragment="single">ECLLTHIRKTLRNNPTKTGSRSGGNQIAESVTTERSPLEECPFTECFDREQNNVQLAKNLDLFLDDVNFTDDGSNINVTIIQPDEFVNKKVTIFLPYICPCLDSGHVYTLFTNRGWVRNLTIDGNLEFTICKAKLYILVYCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXX7</accession>
    <name>A0ABY7EXX7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="125" mass="14424" checksum="DBA104EE8D6C763F" modified="2025-10-08" version="1">MAEDVMRETVFCDAFFPVPGDCDILENLEMLQLQDLSPRFQAVAATFMPYIYSRGPKQLEVSKPVNGSKRKNSSLHLTNVGRDKHSISLHCLPHYTGKTDNNRRKRIENMVRGINVKKIFRKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EYG0</accession>
    <name>A0ABY7EYG0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="74" mass="8428" checksum="EDA84A8D47E58A2E" modified="2025-10-08" version="1" fragment="single">MQLIRLKNGSNVVIQKDIKLCGSAFITTQSPFYDIYCCDGVVHQLEKSEWNTMECCGTKMYNYTSQTCCNNTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EYI2</accession>
    <name>A0ABY7EYI2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Guanylate-binding protein/Atlastin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1000.10">
        <property type="entry name" value="Guanylate-binding protein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003191">
        <property type="entry name" value="Guanylate-bd/ATL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02841">
        <property type="entry name" value="GBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate-binding protein/Atlastin C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="170" mass="19710" checksum="4AE49E0208C6F04B" modified="2025-10-08" version="1" fragment="single">FATLARKYVDALATGAVPDVDDAFASAAKIENERVKDECMDMFRFRINDVQLPLPSTSLDKHFTEARCSALEYMRTNVVQDVASVIEKHALMEMDLFSQQFQRQNEEEKEKHCTNVLLGLASFSNLQAGLQNKCYEVIGGHRKFKRDVDLAREEYEQVLRYYEQREVKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1A3</accession>
    <name>A0ABY7F1A3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_005467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR15362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="274" mass="30972" checksum="FE139D9FB8AE1C36" modified="2025-10-08" version="1">MAEFKCVDVHIDREQCFFLIFGDPEKEHIVFCCDTNRSLKKWIKKLKEAIYAFDSGIGHEEEAEESDDEAEESYDEADDRTTSNDNHGEEPQYENFGHFADQADVQTSTLKKKQANEVVDDKPGDTHDDFYENVLHGGAHKVSCEYPENDDQETHVQRRIKGGRKIGPSKTDAKMDVNTRYPIKTNSCSALETNSENATIDGSGREKKYSTVLKKGESQSMRLRINEFEQSSKSANSFGKGLSKNITSSKLKDLYENVDYPAVKNDKRAGATTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F705</accession>
    <name>A0ABY7F705_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_032569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR17975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="401" mass="45834" checksum="04198F5A0FCE77C8" modified="2025-10-08" version="1" fragment="single">MKLYECKKLTRETSILDQSGKEMKAMDVYSIVLQHFNKRIMQHVNEVKFYQTNEGFSSKHILWMLSIPAIWTDSARQFMREAATNAGLENVRLVLEPEAGALFAIDKPLYMREDKFAGKFPSKKLTRETFILDQTGKDMKAMDVYSIVLQYFNRAVMQQVGQVKNDQPVQGFSSKHILWMLSMPAIWTEYARKFMREAATNAGLENFKLVLEPEAGALYAVDKLLNIREVKSADKFPMKLYESKKLTRETFILDQTGKDMKAVDVYSIVLQYFNRAVMQQVGQVKNDQPVQGFSSKHILWMLSMPAIWTEYARKFMREAATNAGLENFTLVLEPEAGALFAIDKPLYMREVKSAEKFPVGHKYILADLGGGTVDICVHEIVKGRNLCELYRATGDYAGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F793</accession>
    <name>A0ABY7F793_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COLL6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR18063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2183"/>
            <end position="2464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2183"/>
            <end position="2269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2275"/>
            <end position="2464"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="2464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR18063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2464" mass="268635" checksum="41C07EC3D0454071" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFS2</accession>
    <name>A0ABY7FFS2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="169" mass="19587" checksum="87601F0BE4F73013" modified="2025-10-08" version="1">MDTHNDGVMARNVSVTPEPEITDYNLHWRHKDGVFVKRVKSVVEQKHAHDDVVSSLDVDTMDCDGRKSGGARGEEFTEIGPEVFVYSVFFDDRPRQRFIRMIATYKYGKDRDVLNRFYCLFENDVTYNSTSYISTNISFYEMCENHRKPFGGWILSCPVPQELKSIPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGX2</accession>
    <name>A0ABY7FGX2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LAC4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_014826</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd13858">
        <property type="entry name" value="CuRO_1_tcLCC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13884">
        <property type="entry name" value="CuRO_2_tcLCC_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13905">
        <property type="entry name" value="CuRO_3_tcLLC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="34"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="145"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="413"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR20852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="605" mass="67896" checksum="C7BBC9F716AEAA71" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIY6</accession>
    <name>A0ABY7FIY6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026187">
        <property type="entry name" value="Aven"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16524">
        <property type="entry name" value="CELL DEATH REGULATOR AVEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16524:SF2">
        <property type="entry name" value="CELL DEATH REGULATOR AVEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="581" mass="66080" checksum="2D9D410D61AF8D71" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJE4</accession>
    <name>A0ABY7FJE4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HMCN2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_015121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052235">
        <property type="entry name" value="Nephronectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050:SF28">
        <property type="entry name" value="UROMODULIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like calcium-binding" evidence="5">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR21147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="90" mass="9855" checksum="2922B6173BE029E3" modified="2025-10-08" version="1" fragment="single">VDECAGGTSGCQVKCSNVPGSFNCNVDECLLTTSRCQQTCLNFPGSYNCTCDSGYTVQSDKISCRENVILQYVYMYGAEWCCHNLSNHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJV0</accession>
    <name>A0ABY7FJV0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TSN33-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_016464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR22490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="97" mass="10933" checksum="945ED198F5D6D1CA" modified="2025-10-08" version="1" fragment="single">MIQRYQDDEDALMDWAQENIKCCGIKNYKDWNMNMYFNCTKENPSGLRCGVPYSCCRDPDAMKSNLPIIGAIVLGLGVPQLLGICLGRLLDGQIQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKA3</accession>
    <name>A0ABY7FKA3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DCR1A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1074" mass="118423" checksum="91A7691CB8EF3983" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKS6</accession>
    <name>A0ABY7FKS6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="693" mass="79151" checksum="96C3A2D600BE4648" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKU4</accession>
    <name>A0ABY7FKU4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015929</name>
        <name evidence="3" type="ORF">MAR_015933</name>
        <name evidence="4" type="ORF">MAR_015994</name>
        <name evidence="5" type="ORF">MAR_016007</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040350">
        <property type="entry name" value="TMEM272"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444">
        <property type="entry name" value="SI:DKEY-19B23.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR22020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR22033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="159" mass="17398" checksum="B89927D1DE47055A" modified="2025-10-08" version="1">MYHCIVYLFTSSLKSNITGAIHLHDCPLQDLVPIWLIVSGVAPIFFGGSARKQGDDGDESQSPARSVCGVIGLIFNLAWLICGSLWVYPTFGTVNNDDFVPCIGNVTTGCSQDCHKPTLTFAFAMVTIDWIFFVFWFITTLCSFRAICSRSRGGAQISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKW9</accession>
    <name>A0ABY7FKW9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="62" mass="6573" checksum="866C42D88C6B702E" modified="2025-10-08" version="1">MSVCSATAAASSRPGRRGSRSSSTRASTTEQQFYIGKSGLKPLNQRRAYCSTCIQVLVTATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLB1</accession>
    <name>A0ABY7FLB1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MMP21-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_015695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="entry name" value="PGBD-like superfamily/PGBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF323">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="9">
        <location>
            <begin position="242"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="7">
        <location>
            <begin position="391"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="7">
        <location>
            <begin position="447"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="7">
        <location>
            <begin position="509"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="7">
        <location>
            <begin position="567"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR21721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="637" mass="73759" checksum="10A67A091C4912E2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLM7</accession>
    <name>A0ABY7FLM7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="11">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">MAR_015552</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">MELC-2E11</strain>
            <tissue evidence="26">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 22">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="11"/>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 22" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 22" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="25">
        <location>
            <begin position="56"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="24">
        <location>
            <begin position="147"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="23">
        <location>
            <begin position="251"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="WAR21578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="342" mass="37615" checksum="2BFC447797B24B0D" modified="2025-10-08" version="1">MSSKTLRSLWRSRSFLRSALNNRHVRTANIRCLGSAAADLHIGHPQLLQPPVDLLSEDEQMMKDSVAKLAVEKILPLVRQMDAESKMDQSVIDVLFENGLFGIEIESEYGGSNSTFFVANLVIEELAKVDPSVSVMIDVHNTLLMTSFCLSEADSGTDAFAMKTSAVKQGDHYILNGTKLWITNAEHAGAFFVFANAQPTAGLTVGKKEDKLGIRASSTCPIHLENVRVPETNILGEFGKGYKYCIEVLNEGRIGIGAQSMQHQIAYVATQIEAARLLVYNAARKKEAGLSVIKEGSMAKYFASEVAALTTTKCIEWMGGVGFTKDYPIEKFYRDCKIEYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMG9</accession>
    <name>A0ABY7FMG9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDRG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004142">
        <property type="entry name" value="NDRG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03096">
        <property type="entry name" value="Ndr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="59" mass="6695" checksum="6570016E54757768" modified="2025-10-08" version="1" fragment="single">IFPTSLRSPKSERDTDKSWEPFLQHESMVNITSRCAFIHVDIPGQEDSAPKLPAERGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FP73</accession>
    <name>A0ABY7FP73_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="153" mass="16935" checksum="A38CDE4B1EAB9C38" modified="2025-10-08" version="1">MESADARQNGRGNYVPVVSVQYDVPMSPPSPLMYRIRRLGTPQMLGYTRSKSEERVRVNNQIAVSVDSHRLKGMGVGKIYSDYPYHPPPTAPEQNPHHVRPIATPSSSMLANSTFSRSSAHSISQTSPLSNYQTASPSRPERAVLKSAQNTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQN4</accession>
    <name>A0ABY7FQN4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CABIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_038126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025946">
        <property type="entry name" value="CABIT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12736">
        <property type="entry name" value="CABIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CABIT" evidence="2">
        <location>
            <begin position="52"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR24457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="545" mass="62279" checksum="8EEFE18A6178E785" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FT35</accession>
    <name>A0ABY7FT35_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_011094</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd18038">
        <property type="entry name" value="DEXXQc_Helz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049080">
        <property type="entry name" value="MOV-10-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026122">
        <property type="entry name" value="MOV-10/SDE3_DEXXQ/H-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049079">
        <property type="entry name" value="Mov-10_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049077">
        <property type="entry name" value="MOV-10_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21634">
        <property type="entry name" value="MOV-10_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21635">
        <property type="entry name" value="Mov-10_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21633">
        <property type="entry name" value="MOV-10_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="659"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR25390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1034" mass="117108" checksum="CD7E4F3E111D836F" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTE8</accession>
    <name>A0ABY7FTE8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="191" mass="21279" checksum="360E65E7E0519D89" modified="2025-10-08" version="1">MCRPGEDFSARWIHTAYIMPGLLHRLLGIVVVAMYNETGTGLYGEGNLLAVPRETRAVDMSLNDEIKYVIDHKMSACHAPKCQKCFTIAPDPVNPTSNDKRCLLRAAIPNGYCKNGGKPVCEVKAATAEGGQRWKKPKCACKPLWTGTTCTTSRETKILCSCYSGYHEFNGQRSLPHCQDLQKQENWTCHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWB1</accession>
    <name>A0ABY7FWB1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.110">
        <property type="entry name" value="Serum amyloid A protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000096">
        <property type="entry name" value="Serum_amyloid_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00277">
        <property type="entry name" value="SAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00306">
        <property type="entry name" value="SERUMAMYLOID"/>
    </dbReference>
    <dbReference type="SMART" id="SM00197">
        <property type="entry name" value="SAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR23471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="130" mass="14058" checksum="ED19A71BA84129AD" modified="2025-10-08" version="1">MRIDSLTAEKQTSSGTSPSTIAASPVAPAPSTTAFSISIVLLVKIDMRRANTIGADKYFHARGNYEAARRGTGGRHAATLISNAREYWQGGSGRGAEDSAADQEANRGKCEYQFHGGTIMRRKRGERIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWJ7</accession>
    <name>A0ABY7FWJ7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="12841" checksum="5E65C89F93322F74" modified="2025-10-08" version="1">MLDFDAGYTLPPQSGIKQASTTAPTCVLIEPDGETFSAFGYDAETKYTRQVEAEEHEKWYFFRRFKMKLYKKVKVDGSEKSEFHRGKVDVAVQEVAGNGSMKNIFKAGGGDWGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXF2</accession>
    <name>A0ABY7FXF2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_012579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR26875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="436" mass="49287" checksum="C027A5267429276B" modified="2025-10-08" version="1">MGKECIVVGCCNRDTDKQLGLKFHRLPKEETRRKLWLNAINRKDTVTGKDWVPAMTGLEFAVIISYKQRNAKRQLPFQDSQSRPDTEGAELLLHLSATPQTPTDKENSAKGKQHDTCIKLLAEANMKTKQVTEELNRLTLENSELKELKCKLRFAQLSEEEVKFYTGLPSSACFKWLLEYGRVVLPKSKLLEDSDMLLLTLMKIRLNPPQKDLAYRFGISESSVTTYIHAAIPALAKKLTFLIHWPEREEVMSSRPQCFKETYPKCVSIIDCTEVFIAAPADFEARNATYSSYKHTHTVKFLVSITPAGAVSFVSPAYPGKISDKVLTNDCGYLDFIQHGDVILADRGFLIGDELNELGAELVISAFTRGKSQLSARDVERGRKISNVRIHVERAMERLKNFRILSDRMHSNMVPHADSIMTISAAIMNLHPNLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYV1</accession>
    <name>A0ABY7FYV1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Reelin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_011808</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Extracellular matrix serine protease secreted by pioneer neurons that plays a role in layering of neurons in the cerebral cortex and cerebellum by coordinating cell positioning during neurodevelopment. Regulates microtubule function in neurons and neuronal migration. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Oligomer of disulfide-linked homodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the reelin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034968">
        <property type="entry name" value="Reelin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049419">
        <property type="entry name" value="Reelin_subrepeat-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11841">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11841:SF1">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21471">
        <property type="entry name" value="Reelin_subrepeat-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR26104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="86" mass="9086" checksum="206D7B7CC16BA294" modified="2025-10-08" version="1">MPETSGGAKPCYSLREPSTGVEHIVGASLSYDCDVVSTGKAAVFNQDGRRKFVTADLNTTSTMYLQFNIRVGSNSPVSACPAPEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G127</accession>
    <name>A0ABY7G127_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="114" mass="13475" checksum="1E441F9AB1AE1368" modified="2025-10-08" version="1" fragment="single">FKLLNTKENFKAGKTKLAFKKWATLTNNKWILDTISGEIPRQYKIPKPYRFTESEKHAINVELEKFLDANIIEEVGSAHAMREFISNIFFRPKSNGKIRIILNLRLFNERYVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G163</accession>
    <name>A0ABY7G163_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_012678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR26974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="136" mass="15418" checksum="BB6FB42CA9B909FA" modified="2025-10-08" version="1" fragment="single">MITGKRMVLPSITRSNDITSRRTERTRTLNYYINDCKRNHVHCTTDADCTGACDTVGQQAECYENECHCHPYVNCTIDAHCEEVVCDTIGHQALCHENECHCHIDAEECEQDWQCVHCGANSTCDAHFCHGIDCIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3M1</accession>
    <name>A0ABY7G3M1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046958949" evidence="1">
        <location>
            <begin position="20"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR27661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="146" mass="16023" checksum="FA9BEA06720D81A4" modified="2025-10-08" version="1">MAFMKSVLFVCLLMQVCWTGGSPPTTVEVELHVFSGRRDPVFVLHPNDNNYDVIVQKASEQSTTDWPSVLGYKGFTIKEFHGSSQAGSSTEESEVSRVSTVGRCTRVDFELLLLNSITGKVPKGDDQPISDSLLNYAKSDIDKCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4P9</accession>
    <name>A0ABY7G4P9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase FkbM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_014006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase FkbM" evidence="2">
        <location>
            <begin position="138"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR28302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="251" mass="28629" checksum="EDFC09C625C7FBB3" modified="2025-10-08" version="1">MWRLSKYLRSFKYIFRGCIIITIVCVVIELLIINTFILFSLMQVKHLISDFSSSRLSIMDTLAGYNAFRHIVAQGKNEGFKYLIDNTIGRIYMEHESENCGKTISRLGFDVSSAGEFLFILQQMQRQKSEPWKKLVVDIGANDGLMSSNSFNFIQVGWSAILVEPQIDQLDIAKKNHNGDHDGQEKLHVSADLVAMESRIVSEEEQDSNYVEVPSYSVKTFVSKYKVPKHFGVLSIDMEGMEDKGSNVYRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4U3</accession>
    <name>A0ABY7G4U3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="207" mass="23744" checksum="3FC2623F5B67C17B" modified="2025-10-08" version="1" fragment="single">TTRRVSQAIGKREETFVRAETVTISSDTCGDYFDFGSDSFIGPDVTVLYKGDPVNTRLEDGCYIKLINWDSFQQTICIDSWSCGSSTCCTWCGTTRTSNLYVLVKSSHAASRPVVDDVKLRFYRKGLPGRKSYESETSSSYTVGIVVQANLNMDNRRLDTVHTSPIQTQINTNRLLLRPHQRWEEWQSRLRRIFTIRTHRLRPMKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4Y1</accession>
    <name>A0ABY7G4Y1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR28967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="180" mass="20067" checksum="F5B84F53CD2D24D6" modified="2025-10-08" version="1">MAMKRDRQTNWSMDEESTLVDFCSAAKKNEIKRRHFAAGTGGGPAPQEPTDVEMKILSVIPEEMVTGVAGGVDVFEDSCKPPAVKKYRPSEPSGSTFTANSSTHHDISITEVEANGKEDSNTESRPTPPKRNDIAHQMLEEQKKQNEFLAMINFNLAELVSLKRTEVQILSEKHLNKTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5C5</accession>
    <name>A0ABY7G5C5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TAF9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_014273</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR28569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="715" mass="77659" checksum="6F6AA6276105A662" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7K7</accession>
    <name>A0ABY7G7K7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FCN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="136" mass="15213" checksum="522C2629CB6E8A55" modified="2025-10-08" version="1">MTSHTTNELRIDIQRANGSLGYVVYPKFRIEAAPTYILRIGNKTDYGGISSTSVDSFTDTGYGGAVDMAFTTFDRDNDLIVENCALLYHGAWWYHSCYKYANLNGDYVTPGTDSNNAIKFDSMTSLKTSRLMFRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G980</accession>
    <name>A0ABY7G980_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COCA1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF87">
        <property type="entry name" value="COLLAGEN ALPHA-1(VI) CHAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="62"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="150" mass="15909" checksum="4F4D4D2ECDA702F4" modified="2025-10-08" version="1">MRANVAKVAIIVTDGKSNNAAATASEAASLRAHGITVFAVVKVVTLPPTTPAPKADCQAQADIMFLLDSSGSVGSPNFQTMKGFVHDMMNSFNIGPNAVQVGVDTFQTSVKAEFYMNTYQDRPSVQQAINNIAYHSGLTNTGEALRIHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAR7</accession>
    <name>A0ABY7GAR7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="200" mass="21646" checksum="103F4B226F15F3C7" modified="2025-10-08" version="1" fragment="single">MEGQAGESVFSQLTADVLYDYVALKELAVAEIEDEALLGGRRWSGGHGVEQDSYSVKRSGDPVPAEGKTTKGKESGSIAEDVCVPARSEAVIDVYVKRTEEDDLDNMANSFQERYTLLMAATLVNINGATTCKARVLNPLLKEATLKQDAEIAHADRIERVVSVLSDMETSDEDSNVSNVRLVQVSKSMDAQASTPGFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GB69</accession>
    <name>A0ABY7GB69_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="81" mass="9307" checksum="F3DDD6314E3FFE80" modified="2025-10-08" version="1" fragment="single">MEAIASHLVKPSRTDLPYSMIQVGRRDYKRNNFKVFVLTLAVIDLVICGTLIPAEMVKQRKYFEFGDVVTCKVKCFFNVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GCL7</accession>
    <name>A0ABY7GCL7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TBC13-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_034194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF27">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="78"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR31652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="318" mass="36181" checksum="A025A37F2B95E2A0" modified="2025-10-08" version="1">MAHKARLQEFQQTLAAEVIDMSKLRKLAFNGCPDEQACVALFAKDYRALYRQFIDEMIIKPGTEATEKGVMDVTFDDHPLNPNPDSRWQAYFKDNEMLLQIDKDCRRLCPDLNFFQRATRFPCARLCGKNSFETLRKRVEQGVLHSESVSRNRLGITNMSVSRRKGSEEFVPLPEGQEAHWEVCERILFVYGKLNTGLGYIQGMNEILGPIYHAFASDPDPDCEEFAEADSFFCFTNLMSEIRDNFIKSLDDSQCGIVLRLQVVDSDVFSGIPPSRLLKNDLLTGDFSHNMKLVQTANISKSQPPNGAYPEFQSCDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GEV6</accession>
    <name>A0ABY7GEV6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="73" mass="7951" checksum="C7AC4A41AB7BF479" modified="2025-10-08" version="1">MEAVYTRGLRAEKAIKHDVLGSNGKSGFPSTQQVNVKTTFSLTEREGTSRNDSLAKADNEEVSTKDSKEGICM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GIF5</accession>
    <name>A0ABY7GIF5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="28">NOTC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">MAR_033498</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">MELC-2E11</strain>
            <tissue evidence="28">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOTCH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008297">
        <property type="entry name" value="Notch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035993">
        <property type="entry name" value="Notch-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024600">
        <property type="entry name" value="Notch_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000800">
        <property type="entry name" value="Notch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051830">
        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010660">
        <property type="entry name" value="Notch_NOD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011656">
        <property type="entry name" value="Notch_NODP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033:SF151">
        <property type="entry name" value="NOTCH 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06816">
        <property type="entry name" value="NOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07684">
        <property type="entry name" value="NODP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00066">
        <property type="entry name" value="Notch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002279">
        <property type="entry name" value="Notch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01452">
        <property type="entry name" value="LNOTCHREPEAT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01983">
        <property type="entry name" value="NOTCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01334">
        <property type="entry name" value="DUF3454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00004">
        <property type="entry name" value="NL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01338">
        <property type="entry name" value="NOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01339">
        <property type="entry name" value="NODP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90193">
        <property type="entry name" value="Notch domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50258">
        <property type="entry name" value="LNR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0010">Activator</keyword>
    <keyword evidence="14 22" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="16 23" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 23" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-0675">Receptor</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="18" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="1408"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="1506"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="6"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="173"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="214"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="254"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="292"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="330"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="368"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="405"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="443"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="480"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="520"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="557"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="595"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="632"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="682"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="716"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="754"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="792"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="830"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="869"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="917"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="955"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="993"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="1031"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="1069"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="1108"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="1140"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="1179"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="domain" description="LNR" evidence="27">
        <location>
            <begin position="1280"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="domain" description="LNR" evidence="27">
        <location>
            <begin position="1321"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="22">
        <location>
            <begin position="1706"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="22">
        <location>
            <begin position="1758"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="22">
        <location>
            <begin position="1791"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="22">
        <location>
            <begin position="1824"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1547"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1662"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1890"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="2058"/>
            <end position="2086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="2169"/>
            <end position="2260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1557"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1664"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1890"/>
            <end position="1899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="1905"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="1938"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1950"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="2211"/>
            <end position="2230"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="641"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="857"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="895"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="943"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="981"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="1019"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="1057"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="1096"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="1167"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="1205"/>
            <end position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="WAR30956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2260" mass="246377" checksum="1F8AEF7350C3E92F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DA31</accession>
    <name>A0ABY7DA31_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">STAR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_006650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053202">
        <property type="entry name" value="EGF_Rcpt_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009:SF2">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase FkbM" evidence="2">
        <location>
            <begin position="159"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ94179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="344" mass="39590" checksum="BBA0C0655F5D580A" modified="2025-10-08" version="1">MKSSVTRAVRMRVSTFGYLLGTSVLCGLMYMLYKNQTRQITASDVYMQAPPTGSHDQHMVAAFEQKRQFAVHEQEFQPMVIPFSRNESFDYKSAMQKLNDAKVNADDPRLIKLIRDYYIDPPSTEKYNLDIPNRLEYSNGQTPFVDSRLNYMEGGFYIECGALNGEKGSNTLFFEKVRKWNGLLVEADPSNYALLKAKHRKAFTMNACLNTEPHPSVMTFNKAFNRGRIVHGKESQDWIKKQNIKKDEVSIQCFPLYSILLALNQLTVDFFSLDVEGDELRVLQTIPYDKVDIKMMTVEYIHETGKGTDLKSFVESKGYESMLQVMRWDGGVNDIIFRKKGLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DA53</accession>
    <name>A0ABY7DA53_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_006289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046054809" description="B box-type domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ93818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="650" mass="73557" checksum="AD22E6DE601270BE" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAM7</accession>
    <name>A0ABY7DAM7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HMCT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ93439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="83" mass="9497" checksum="2BB6F87D9F43268C" modified="2025-10-08" version="1">MKTCDNRLVYDTLIQDCGQETCVEGCDIEPCQPGQVYESNKEPFKCIPEAFCNTTCLTLNGKEYKEGERILDSTICRMDCEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAU0</accession>
    <name>A0ABY7DAU0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046172737" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="10005" checksum="9894DA532EE388B8" modified="2025-10-08" version="1">MTLLCFILITCCGLSVVNGDEVAEKAVREYRELCPLTTLCPSRSKTTPTPTTTRTTLLDERTDCYIFFQPPEDLTAGVDVDVSLVPKDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DD03</accession>
    <name>A0ABY7DD03_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">LRP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_006947</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF5">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046369051" evidence="12">
        <location>
            <begin position="20"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="813"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="93"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="946"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1140"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="93"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="946"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="980"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="993"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1014"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1155"/>
            <end position="1164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAQ94476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1164" mass="124733" checksum="340CCE1E6012D3E5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DEA2</accession>
    <name>A0ABY7DEA2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="444" mass="51830" checksum="C0FE9D6554DC190B" modified="2025-10-08" version="1">MAAVDYQSLDLKDNFGSKCQEDRNNISSRLGKRTEEEIREEHRTLRVLRKIEGHQNQIFEVVSSIKREICRTTSKEGQEIDNNPHDQSDTSVDANSLTIEITQEEEHLSELNLQLDEKKETITKLEETVADNEEQIDVLNVEVRKLAAEKEQLSGDGENNKARIEELQKKLTDKNEKIKEIEKERRQLHQMSDTAEQNSCLQKRCSSIEKEIATNAEEIDDLNREKEDLLAEVNEQRQARENQSKIIELVEEKTGAKYEIEGLKKDIQKERDKIIELVEEKTGAKYEIEALKKDIQKEREKKIELVEEKTGARYEIEGLKKDIQKERNKIIELVEEKTRAKYEIEALKKDIQKERENSTEITKKQNELDEAKKEIEKYKLELEEEKAKKTTNRRRNNSDGDTSRARGRFKTGDPQLGYLNDSDARTNSGFNDYNKYDILNDLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DF29</accession>
    <name>A0ABY7DF29_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UROM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_028032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057774">
        <property type="entry name" value="D8C_UMOD/GP2/OIT3-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23283">
        <property type="entry name" value="D8C_UMOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="UMOD/GP2/OIT3-like D8C" evidence="3">
        <location>
            <begin position="82"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ95342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="158" mass="17824" checksum="961D1BC55C6DB6BD" modified="2025-10-08" version="1">MENKIYLKKNHNDPCAATTITTPPTDDPCLPANHRNITNLGMRYAHNTECSKHAISDFRLHETWYYTGHDPILTSPPDQLCACGTSLPIWMNGTLPQPSDGIVSREACQKYAGSCDLRLHIEVKNCGDFYVYKLPPTREDNTAYCFGVYPPGYTEPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGG2</accession>
    <name>A0ABY7DGG2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_028761</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="214"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ96071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="352" mass="39557" checksum="874B6CE28ABFDD69" modified="2025-10-08" version="1">MVKRCAWGLCKSDSRYPERLGEGVEFLPFPKPKRNLNKCLRWIMACGRPQDQLNPEYVNGNYHLYVCTKHFPEGKPTEKFPDPLPAIATGFVKIAPKRPPPKQRNATLPVPKAKRKVLRDQDPGNESNVNTSQCPASDDSTKPAGSGPMMLPVNPPNPQSVETTSKSNNEEKPKDNTPSLEFQALTEINKRLQQQLAKQILMNDDLRRENATLKGEIKSMQKCVQRDRPPRKRPSRAGSSSQIQTLSQNGNLSQNECSSQIGNLSEIGKLNTLSSIGNSSQLRNFVQIKHKSQIENLSQTKNSTEIEIVRGNSHSFLHPLCEENPCQPNLEISNGYVKDWENNIIVVKQEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHN2</accession>
    <name>A0ABY7DHN2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_029458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ96768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="57869" checksum="B0A906EB15B571A1" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DI65</accession>
    <name>A0ABY7DI65_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">NU301-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_029623</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15559">
        <property type="entry name" value="PHD1_BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15560">
        <property type="entry name" value="PHD2_3_BPTF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038028">
        <property type="entry name" value="BPTF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45975">
        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45975:SF2">
        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00571">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DDT" evidence="13">
        <location>
            <begin position="173"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="327"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="2336"/>
            <end position="2403"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="2430"/>
            <end position="2500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="497"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="978"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1216"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1554"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1605"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1939"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="2156"/>
            <end position="2193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="533"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="978"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1001"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1216"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1554"/>
            <end position="1567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAQ96933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2526" mass="280725" checksum="E9676B427FD38F96" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKP6</accession>
    <name>A0ABY7DKP6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ97463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="67" mass="7076" checksum="6190E1D33AD6C906" modified="2025-10-08" version="1" fragment="single">MAAMSLIKTDAPEELEEVNVTGISVEGQETSLLVDDEDIVMVPTELVLAACREGQSPEGLASELSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMK7</accession>
    <name>A0ABY7DMK7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_023299</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein-tyrosine phosphatase catalytic" evidence="5">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ98926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="132" mass="15434" checksum="9414EF4235EF0C96" modified="2025-10-08" version="1" fragment="single">VKCLQYWPEMDQTCSFGGIDISVTGVEELSDYEIRTLIAKKCRCTFIALDNLVDQARTEKCVRPLQVVEYLICQRVNMVQTKDQYVYLHRALAEALLMGTDHVWHRQFEEVHSFMIATEPGEKQTRMVKQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPH3</accession>
    <name>A0ABY7DPH3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_023189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ98816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="148" mass="17101" checksum="4289CE1B375196A0" modified="2025-10-08" version="1" fragment="single">MGTYFSAQTTESTFYTSEQSQAEVLSELEDKLYVWNEKIKAIRWKIKHSECIREILPSEIRAASEYLRTKLIEVQGVGYNAHQAKSDHENNRPPSVSEPGQEKKNKYNPVQTNSYEELQNCLVNALEHNARLEESNKRLLAQLEELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTH0</accession>
    <name>A0ABY7DTH0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mediator of RNA polymerase II transcription subunit 16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MED16</name>
        <name evidence="15" type="ORF">MAR_024756</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048616">
        <property type="entry name" value="MED16_bridge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048338">
        <property type="entry name" value="Mediator_Med16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048339">
        <property type="entry name" value="Mediator_Med16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021665">
        <property type="entry name" value="Mediator_Med16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224">
        <property type="entry name" value="THYROID HORMONE RECEPTOR-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20718">
        <property type="entry name" value="Med16_bridge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20719">
        <property type="entry name" value="Med16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11635">
        <property type="entry name" value="Med16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0010">Activator</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Mediator complex subunit Med16 N-terminal" evidence="12">
        <location>
            <begin position="119"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 16 central helical bridge" evidence="13">
        <location>
            <begin position="458"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit 16 C-terminal" evidence="14">
        <location>
            <begin position="737"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR00384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1578" mass="170999" checksum="EA74C0DAFDFEF063" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DW74</accession>
    <name>A0ABY7DW74_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GIGA6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF15">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="23"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="459" mass="51139" checksum="70C41570BFFB70A1" modified="2025-10-08" version="1">MYVPPTMTTVPISRIQALACRKGKNPGLAASAVKDNRVVFADGYGVADLNDGRKVTNRTLFGIASMSKAFASALMIKLLHERNMSIYTKPGSIMPEGFAYNTSEFTTYATVRDLMTHCLGVPSNQMMRLDDTLTRKDAARRIRYFAPVYKFRMHYLYSNLHYGIVSYLSELLGGQPWERLIQQHIYDPLGLRGRRWGTYAGSTGLMSSSADITKWMLMQLGGGRSEVGVQVLAADDLSLTHSPQTAIRSSTVEKKFHQPLAPFTVSESNYAFGWKTGFYKGYKMLRHTGTTFGYSSLITLLPDVNVGVHILDSLLGEEPSINETTVCTFPEPWYAASHSLRHPIDQSLPPSRPLDAYTGIYHHIAYGNLTVTVNTTVNQLQMVYGIGRWILYPRNTHDSFTGEAFGLMYRLVDLISGVRFHVHTHSPTTLTVPDFESREPPVFMRTGDVPPKAGVSIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWH1</accession>
    <name>A0ABY7DWH1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondria-eating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_025033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031981">
        <property type="entry name" value="MIEAP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16026">
        <property type="entry name" value="MIEAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondria-eating protein C-terminal" evidence="2">
        <location>
            <begin position="87"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR00661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="316" mass="36574" checksum="37FC2E4735CB134E" modified="2025-10-08" version="1">MEEQHSKYQTLEKRCESQKQENVALQAQMKSTDDHEVEHKRQIRHLESDQEILKEELRTAKERVSSLLGERLTLSAGVSDLSDPYGPTKIAEMYSALYDDLWTDAYQVSEVVFQGKREKNRVKKLIQVLLVHKFCKEKQHQDANILRAMFRKSPNNCEQLPQDVNRILRDVLRVSYEMAIGNINKKFSEELDNSKVVCKFASEIPQFVEACFHICWLMLMHDPPVVIQKNVTKGSPFDKGSYKPYMTTGDKIDYVVWPALLLHEDGPVIAKGVVECFRSTAYKQKTTCIKPEKQQVGYPEIDDAHARFDNNFDDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DX94</accession>
    <name>A0ABY7DX94_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LNX2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_008072</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd06679">
        <property type="entry name" value="PDZ3_LNX1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF84">
        <property type="entry name" value="LIGAND OF NUMB PROTEIN X 2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRAF-type" evidence="7">
        <location>
            <begin position="138"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="212"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="342"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="461"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="577"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="138"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR01514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="668" mass="73047" checksum="10927EB568547DFC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXY5</accession>
    <name>A0ABY7DXY5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR01009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="146" mass="15433" checksum="D953A26D0C071B5A" modified="2025-10-08" version="1">MSLAHVASTTDMGEHISHAGMPTEFCGLTGGTLADGLKVDLGHLSPGGKSDDGGLYHHDPGSPDDAAKAPPYAVHAGSAERAGTQLRQDSLPRHLHEGGAGSPRRPYGVASTGAHKFMLYYDVILSQTFIAHRPYPLPYRTIPHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E082</accession>
    <name>A0ABY7E082_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD repeat-containing protein 76</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_008816</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050853">
        <property type="entry name" value="WD_repeat_DNA-damage-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR02258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="402" mass="44693" checksum="3B9F4DD80F7B2828" modified="2025-10-08" version="1" fragment="single">MSSSRTRRSTSKRKEDVLPVKSSHSQPKKIKKRPVKDEPKENFVDVKAETESDASDFGDDVEEYRKRIEENVRQNQEFLRQLGIDQNKTPEGIELPPESVIARAMYSVPATDEHPRPHSGPLDMKETLYIDRMSKARMSAESVAKVTPERSFSVAIHPGKSRLLAATGDKWGKLGIWDVESEESSESDGVVCYCPHSRPICGLEFPVFATHSVYTCSYDGSLRHGDLNKGIFDEVYSLPEEDDILLRNFSFTSPNTLLVSQNNGCVALVDTRTASACAEHTYELADRSLRTVSVHPTQKDYFCTAGVGGVVCVWDLRKVSVKKSKAIVRLEHSGRNLNSAYFSPSQQPHRSLVDRIPCKLAPCTGRCVCDDTYLGSVCSLNALHPTRDVVVGANSSGRLHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0J2</accession>
    <name>A0ABY7E0J2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MYO19-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_010081</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00124">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF289">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-XIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="63"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="641"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="729"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="905"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="800"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="157"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR03523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="988" mass="110766" checksum="FD91E1B3DB29253B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E319</accession>
    <name>A0ABY7E319_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TRPM2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_019752</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF12">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="721"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="761"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM SLOG" evidence="11">
        <location>
            <begin position="75"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="12">
        <location>
            <begin position="419"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="10">
        <location>
            <begin position="664"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="600"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR04383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="862" mass="98569" checksum="D958923D2B34CDFB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3A0</accession>
    <name>A0ABY7E3A0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RM44-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_009840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd19874">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055189">
        <property type="entry name" value="RM44_endonuclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22935">
        <property type="entry name" value="RM44_endonuclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL44 endonuclease" evidence="2">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein mL44 dsRNA binding" evidence="1">
        <location>
            <begin position="162"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR03282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="264" mass="29883" checksum="4480E0AD71EA3753" modified="2025-10-08" version="1">MALGVFFFRLKMTANNDIVSRMLIELSKDDQLHVIRHNTTYAQQATSSRRGWAYKTELSHRRIEVGPEEERHPAAYGCWNHDSEVYAFGQRLGENFDEKKLHAAFVQRAIHDFLMSQSTLLQVATSLGVRDLIQSVGEKQAEMFVLDFIIPQLVGRDVTEMWDLPNPMGLLSAMLKSAGRGEPEPRILWASGKNTLMPVYNVGIYVDKKLIGKSPGESAIIAEDMAAREALKNLMNVADSRQPLLLGDRLREVTLDYERTANDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3E0</accession>
    <name>A0ABY7E3E0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UFD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_010029</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="4">
        <location>
            <begin position="15"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="5">
        <location>
            <begin position="101"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR03471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="255" mass="29206" checksum="25B6B2899E21606B" modified="2025-10-08" version="1">MFGRMFPEMPNGRNFGETYRCYSVTMLGDREDVERGGKIIMPPSALDKLTRLHIQYPMLFKLTNKKMKRETHCGVLEFMMKNLLLQEGDLVQVDNVSLPIATFAKFQPQHTDFLDISNPKAVLENALRSFACLTVEDLIEFKYNDKVDFAAPLGYKEPERQKPRDTEQEQDMEIFQGKGNRLDGKNKGLECMETQSSNGPPKRGIPNYGYKKNTITFIRNSRKAENGAQSPEDKMFEAFSGDGQSLRKVKTKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3T5</accession>
    <name>A0ABY7E3T5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PHF14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_020026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd15562">
        <property type="entry name" value="PHD2_PHF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15563">
        <property type="entry name" value="PHD3_PHF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24102">
        <property type="entry name" value="PHD FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24102:SF28">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="277"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="572"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="501"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR04657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="634" mass="72519" checksum="494C372DC971836B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5D9</accession>
    <name>A0ABY7E5D9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_008924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR02366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="114" mass="12809" checksum="33D9B44C0D81A993" modified="2025-10-08" version="1">MASLYRYGSIRATPLVRGSSGFSTLPSCPELRGIQSRRVPQYGYGAPTPNTYPSQGNYPPPPPGAFNTYPQGQNDAQMATNRMMMLQRRRRVYMGVSVVILIMIIIYVVVRFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E697</accession>
    <name>A0ABY7E697_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SVEP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_019682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393:SF7">
        <property type="entry name" value="COMPLEMENT C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0768">Sushi</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="43"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="102"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="163"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="200"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="260"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="317"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="367"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR04313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="596" mass="63092" checksum="20D2ED21C9C96CF3" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7E0</accession>
    <name>A0ABY7E7E0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SVP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="378" mass="42198" checksum="01ABF37A255225F1" modified="2025-10-08" version="1">MNWGKGSVEGRLMDWGKGSVDGRFMNLGSVEGRLRNWGKGSVEGRFRNWGKGSVEGRFRNWGKGSVEGRLRNWDKVSVEGRLRNWGKGSEWGKGSVEGRLMNWGKGSVEGRLMNRGKGSVEGRLMNWGKGSVEGRLMNRGKGSVEGRLRNWGKGSVEGRLRNWGKGSVEGRLRNWGKGSVEGRLMNWGSVEGRRRNWGKGSVEGRLRNRGKGSVEGRLRNWGKGSVEGRLRNWGKGSVEGRLRNRGKGSVEGRLRNLGKKRQSKGNHSIENSNSNQVHLHRITLRSSRLVLWPRRLGVCHRKSPRSPCSLGPWCPYLRSDHRMSPGVLPVSQVACAPASLSPGVVVDYLRPIVNKLNTVNKRLDALNTLEKTVILKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E7N1</accession>
    <name>A0ABY7E7N1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHC class I antigen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="10019" checksum="38AA5F0D3A367E03" modified="2025-10-08" version="1">MLHAHGVARDLLGRGARRSKEMYDMRASFTEYEIGDLELAIEGEFHCPVRQKGGNKVFHHDKMKLNQGRSTPKWVEDLKRELQHQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8P5</accession>
    <name>A0ABY7E8P5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_020696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="227"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="5">
        <location>
            <begin position="747"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="458"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="2">
        <location>
            <position position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR05327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="893" mass="99221" checksum="72B0C0BFF0D8B147" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9L8</accession>
    <name>A0ABY7E9L8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="85" mass="9611" checksum="A5B5F039B2F3885E" modified="2025-10-08" version="1" fragment="single">VLIERITAHLVHTPMRDLPTVCLARTGHSMVDIFNESASEYKGCAQLARFNRIRNRIHVFHVLKDLTALGKDKQLLLEHAHQGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAR8</accession>
    <name>A0ABY7EAR8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_019625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR04256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="439" mass="48024" checksum="EBF215D3679684ED" modified="2025-10-08" version="1">MDNTTIASPVPNSVTLPTDGPTNVWMYAVIAAATLFVIFLAVACYSLSEFFTKGPRPRRKDEEGDKAEGADNIDGMTAECNHLDMNGSRNVADVDSSVNTRSSVESDIEPSEQDHLIEENEKFIAPIAKKGTFAKEEEDVFHEYRGREPLQGRSTLPHRSRPPPIILLKSKSLEHEEAYESDDSIGNAESLRSQFSARSKMSRLSKLSVTSGPTIQIDPEEAVCKDALSPGRPVNIGFISYSSVDTEDSNAPESSASCDSDLSPRSLPSDTLSDLSPSNRKGTNGYGSDKVVKNVALDSLRMKSQMKQGGKRSDEDSGRDSLPNSLNNAQGKPEKTLIPRLDVHKVGKTSTNGRTAEGCNDTLLCHSPSIGNGGVPPHTPWSRPGTDCEYTCLYQEDPDHPYDMRVLRPAIEMQADWGYQSQTHNNRLKPEASMYNLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBS7</accession>
    <name>A0ABY7EBS7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1463"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1560"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1777"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1971"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2028"/>
            <end position="2048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2118"/>
            <end position="2147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2168"/>
            <end position="2196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2295"/>
            <end position="2316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2392"/>
            <end position="2438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2516"/>
            <end position="2570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2599"/>
            <end position="2619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2852"/>
            <end position="2926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="733"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="768"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1468"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1483"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1777"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1832"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1858"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1980"/>
            <end position="1992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1993"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2133"/>
            <end position="2146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2168"/>
            <end position="2183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2295"/>
            <end position="2309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2416"/>
            <end position="2428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2529"/>
            <end position="2543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2559"/>
            <end position="2570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2603"/>
            <end position="2613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2885"/>
            <end position="2911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2979" mass="329573" checksum="73CC8F9A637C1AA2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECH3</accession>
    <name>A0ABY7ECH3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="173" mass="19484" checksum="410805009EFE333E" modified="2025-10-08" version="1">MEESRDGSIAPSDDTYDRSMVVGSQTSSWVCSRDGRSPMSPDHSLSKIRSSRLILLHKAQRIGGFTGADSIRRELHELRAVGRPDGWWHGRVSGRLHRSLGRCKEDLHGPHTYDRSMVVGSRTSSWVCSRDGRSPMSPVPFLSKAKMLRRIHDKVKKRQVEKPRGSSSFCTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECX4</accession>
    <name>A0ABY7ECX4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HMCN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_021613</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="86"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="171"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR06244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="493" mass="53833" checksum="9A5E8718D1EFE886" modified="2025-10-08" version="1">MVNSPVRILSERSITINCSSTGNPSPKYAWKYPGGGSQTGPTFTLASVLRTHAGDITCTATNNLSPTGGGMVDRARQTTANPPSRPLCTINTTTISTNAVILEGTDCNISCSSDAFPTQITYSWSTPGRELVTGKSLFLINVTRTSDKGQYILTAKNTMSPTGGHTETVRPEVDLPETYDIFMGSVLNYSCPFIPGDPSQTSLYWTRSVENRQWHGQFVSISSVQKSDAGLYTCTATNRMTPTGFPNRNGNKSLVSDFHVTEYIATVNVTKSEFSNATFNCTVDSNPPSTINIRKDGKIRRSVDNSKQLAYTIANLTCWDAGRYTCDGSTPRRSPDLDITLNFTAELHKNATLQYTVIAYPVPSPSQFVWKRCISNSKNCSNLSNLSGKTKVTTVGLSSSLTILDIDMDDFGVYSISIANGIGEELVEEMYLQPVGPPDLPTAFDTIEKSIGETQATLTWIPGFNNGFRQTFHLSYRTLNEFATVFNTAHQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ED28</accession>
    <name>A0ABY7ED28_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H2A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histone H4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MAR_016972</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">MELC-2E11</strain>
            <tissue evidence="21">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0488">Methylation</keyword>
    <keyword evidence="18" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="H15" evidence="20">
        <location>
            <begin position="326"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="430"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="641"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="430"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="487"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="649"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00020836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="WAR07014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="707" mass="76979" checksum="5D7147A2B598644A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDM0</accession>
    <name>A0ABY7EDM0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BIR7B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_018061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01282">
        <property type="entry name" value="BIR_REPEAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="337"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR08103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="384" mass="44242" checksum="1F08FA5886A2752F" modified="2025-10-08" version="1">MKTQTMLQRKQSNMVLCKLLMPRNPMQRTLEFTADEPVKILVGRKEREEPIPDNDTDPDWSDGDEPLFEHTRHSPNCLFLKELLREQLLNTNRTRPTQQRARRVWHPGMTTLDQRSGTFKEWPSSNGQQPETLANAGFFFTGSEPCPAQQLNRQVLHPGMTTLAQRLGTFNEWPQSTGQQPEALAEAGLFFTGINDLCRCFTCDGGLQRWDREDDPGVEHARSSPDCRYVREMKGQRYINMVHPAAQREQLEDCIDIQGQHSSGGITKYKSAIINVHRRGYAWDRAHKAAMEYMRRGRSLNNLVADDLQAILEERDTPLSQEVLLEENERLKRRLKCSICHRNQVKVLFLPCGHLVACENCAPICTHCPRCQTRITHTFRVFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFB6</accession>
    <name>A0ABY7EFB6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="156" mass="17042" checksum="899DA50934B5EA6E" modified="2025-10-08" version="1">MYKNSKAAVKGKIDLTRKTDGGGMICLSQSEEVMANHLQVFNARQLNGVPEGFECGAAAKDEHGVVEESGWSSLLENMDTDIIRNVIDYHPSEADICKPNTPLEDAVGDCDVPSTSGFVPSKGKMSRRKRKSDAGDQLFQLEEKRLTAETAAFYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFJ1</accession>
    <name>A0ABY7EFJ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751:SF42">
        <property type="entry name" value="PROTEIN CBG10204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751">
        <property type="entry name" value="SI:CH211-108C17.2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="533" mass="59735" checksum="539BD82438E597CD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EG15</accession>
    <name>A0ABY7EG15_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BON1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copine C-terminal" evidence="1">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="131" mass="14606" checksum="A6B233F584CA32AA" modified="2025-10-08" version="1" fragment="single">ASNGTPEQTMSLHDVSENKSAISRYKKAMKHLRMSGPTRLKPVISFAESLAVREPTQDSQVYHVLLVIADGILNDIDDILERLTSISQLPLTFVFAGECFSKDSTGFVGLKNRTTSLSRKHTHFVSFPRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGA5</accession>
    <name>A0ABY7EGA5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CPL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_018995</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045465666" evidence="7">
        <location>
            <begin position="18"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="45"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="133"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="367"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="455"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR09037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="670" mass="74446" checksum="C710D8603B50F7B2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGY1</accession>
    <name>A0ABY7EGY1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BIR7B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="144" mass="16170" checksum="C944B1EE15D45DFD" modified="2025-10-08" version="1">MDNISDRMNTFDNWQYKTSPTKLAKAGFYSIGYHDIVKCYSCGTSLRYLAEDDDPWANAESSSAARTSPRSVEKAPSEMSMSELKEDNRRRRAMLECRVCRERQACMLLIPCGHRAACGDCAPNISTCPDCKGDVTETLKTYMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJ61</accession>
    <name>A0ABY7EJ61_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="473" mass="52335" checksum="E77EC5D1AE14B882" modified="2025-10-08" version="1">MKFECRDLFSEGNDDDDDDDDDDDDDDDGGGGGDDDDDGGGGGGGGGGVVDDDDDDDDANIRRNFDTIVCHDIIRPTENNTAELPYNIYETVVFSRFTGTDGTALAAAGPADMSANHYRACRAQQLSYSPLITRRPATSFVSRQAFSPAPRIHSAQSRVAMTATPRTQVSMAGFYDWSTEEFEDSTMPTFYQKIAVNHKGKMNKANKAWCADGIHLNPGRMFIRDKANLTKGEREIIAGICKNRGDTKTNFVAHVKSHKDAWLVGRQAQRGKPGHNSDSDKCSIKIPENLFSRIEPPAVHSDRSYFCDKCKEDCTLTDHCRRHKYDVKNDVIGRKAPPTSPELSPATERRIPKNPKTNEGAVFVESGKTFYDVNEGAKKKKVYVDVFLPKFPTQGLQEEATSLTLPDNDRESARSSKINSNSQPKLFKISERSPEHTDEGYSSQERSPSNTKQMPYRALLSRSSGKPESGCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELK5</accession>
    <name>A0ABY7ELK5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CO4A2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="824" mass="85338" checksum="4BECCF584660C4A5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELQ1</accession>
    <name>A0ABY7ELQ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MUC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_034639</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="447"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR09563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="624" mass="66536" checksum="6415116555530C94" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENR8</accession>
    <name>A0ABY7ENR8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_035115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR10039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="424" mass="46423" checksum="8966B3F8B5D51839" modified="2025-10-08" version="1">MGNGISIPLPCTATNGNQLTLEPISLLFMLVYGIALVIQFVSMFFHRLGTALHIMSSTDINCMKPNTRELNAMDIAGKIALVKEMQQMDDDDDKMSVTTTSSSGFDDDSSITQAGGEIPVAAGDNLGTKFVKNFMDLANDLRKERISETSNHSHDKFGTRKGSSSTKRKSRKTIRAMTSIQQDRDAVLHKADAIETKLQKIQKRNGGAEASTGKVDSWLHLVRDVLTQSRISLNTIGEEEKRSSLPWRNRLSRATSVEGVPREETKGKGMPKRASFGGSTPLNIIADNDEEEDMLMLKSKAKNATDRHTVTIDDVAYGKVKVDLRPRSNIVTRAVNKDNDMKLNRLSEPAKTHVGASPRISEEDARANSIESESDMSEPEASDTGSNSGAPSVTFNNKPEYIENFREAGSVSVPAPDDVFIVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ER01</accession>
    <name>A0ABY7ER01_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cathepsin X</fullName>
            <ecNumber evidence="3">3.4.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_025717</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.</text>
            <dbReference type="EC" id="3.4.18.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.18.1" evidence="3"/>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd02698">
        <property type="entry name" value="Peptidase_C1A_CathepsinX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033157">
        <property type="entry name" value="CTSZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047509405" description="cathepsin X" evidence="11">
        <location>
            <begin position="18"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="12">
        <location>
            <begin position="70"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR11537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="300" mass="33229" checksum="55D74DA303D2FF88" modified="2025-10-08" version="1">MKLQILFSAIFVSFSCGAVVEEFNMLDLEPATYTGKKTTSKYGFIPMIEDKDFGVKTYSRGHEELYMADIPANWDWRNVKGINYASTTHCGSCWGMGSTSALADRINIKRKGEWPSAYLSIQNVIDCGGAGTCEGGDDRGVYQYAHEKGIPDETCNNYQAKDQKCDPFNQCGTCTTFGKCAQLQKYNVTKVADYGTVEGRDNMMKEIYTNGPISCGVMATDLFEQYTGGIYSEYHLFASINHIISVAGWGVSENGTEYWIGRNSWGTPWDMDGKGGKYNLGIESRCAYGDPIVPSTPYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERD8</accession>
    <name>A0ABY7ERD8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_025466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="131"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR11286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="408" mass="47346" checksum="BAFF28AFF6A79053" modified="2025-10-08" version="1">MSRRPHSDTKKRNQHTSRNMGNFFSAEEQATVKSSQRLASAQSNVSRDSSIEIGPIWIETINSLVDDHMKVAEHISRLEEELLELKKTYMTKHDEIITTAERIKRTNKPDNGAQSEHEEDPSTTVEMSTKIDELKRNHQQFEVLIKDQEHILSRIETEVDKHGDKIKEHEESINLLKEQHKQRKGNIRTQRIYIKSLQKDLNTYGKRITKIDTENKKSNKKSLKHTKNCKPSPPIDIQTEQKNTEMARNTQESVKTKDIIPSIKVQPKPVQKKTWKYAFVLNKELTQAFQSIKSEKLGFFNSTADHNYFDEFIDILKEDVIGVSMHEYSPTRGISAFDRILVFGTCTLRVESDSNMALDKIPKEHRSKVFLVMFHKTAGSKTPQEVYMYTFKHAEVARELHVPFKLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETJ7</accession>
    <name>A0ABY7ETJ7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S12A6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_026444</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00930">
        <property type="entry name" value="2a30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF73">
        <property type="entry name" value="KAZACHOC, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="562"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="88"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="339"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="7">
        <location>
            <begin position="659"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="7">
        <location>
            <begin position="777"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR12264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1041" mass="115687" checksum="FB1D24E63EB45E59" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWU6</accession>
    <name>A0ABY7EWU6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="77" mass="8581" checksum="128E89C558333596" modified="2025-10-08" version="1">MDFDFTRKTMNPNKAPPMNRPVPAPRTVLPKRESPSRGTSAMATNENPVDSPACRDFSSKLKLFDQQSKGESECKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EX28</accession>
    <name>A0ABY7EX28_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CAS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_003960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040373">
        <property type="entry name" value="CASZ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12451">
        <property type="entry name" value="TRANSCRIPTION FACTOR CASTOR PROTEIN MING -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12451:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN CASTOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1094"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1302"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1550"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="732"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="955"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1112"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1376"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1415"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1476"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="693"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="741"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1120"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1422"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1476"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1499"/>
            <end position="1508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR13855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1699" mass="188864" checksum="41EA222EA276B9A8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXV2</accession>
    <name>A0ABY7EXV2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="196" mass="21336" checksum="08733E049934DBC5" modified="2025-10-08" version="1">MEIKYDLIRRYNSSANGKRKVDETWGEVADAVNAVGNGPRTVVQVKEKWRNLTKKAKTDYTAEQASLGKTDGGPALPEMSTGSYAIIDLLKDSASFSGITGADLCETAEAKDTESAVKCKDLGKSKPQAAETYARASASASQNMSATRVTPQNEKAKTLKELQMAYYMEATENQKAQKECFQKLSTLADVLTLKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EYT2</accession>
    <name>A0ABY7EYT2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026491</name>
        <name evidence="2" type="ORF">MAR_026545</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="71" mass="8311" checksum="09053DF7853C7D08" modified="2025-10-08" version="1">MECENGYHSVSGNVCNWGWNCDSEYHKGRIYKADYEGFVFDISQALQLMDKIATQWVADLVRELGRQYGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZ18</accession>
    <name>A0ABY7EZ18_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="109" mass="11636" checksum="083BE14D3CD02597" modified="2025-10-08" version="1">MYPCCAPTHIQDNAACNGTRVSLYPGQRAITCTCSGLNQNRLIMGLETLTTTTTTTNRTEDSILAPQSYGLGLISSLFSTAGCCNFVALTCSVILAELLINKRAVPVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZI4</accession>
    <name>A0ABY7EZI4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GL8D1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_004609</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050748">
        <property type="entry name" value="Glycosyltrans_8_dom-fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13778">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 8 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13778:SF47">
        <property type="entry name" value="LIPOPOLYSACCHARIDE 1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR14504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="359" mass="41879" checksum="F1A375A3213418DB" modified="2025-10-08" version="1">MAFTSTKKALLAVGLVWLGVMFCLWFRDTVHLDRLLELTQRSQNNDSPPQSGKFEAKAFQMARFNKTKLEQDDVVHVCITSDENTLGGMVALINSIDQNTHHPIMFHLVVDQNSLTHIKTWLEGSRLHDIMYEVIAFQEEWVRGKVKMNYARYYFPQLFPDLHGRIVFIDDDSIVQGDVYDLFKMTIKPDHWATFAEDCTGSAKRITMMQNHYADYIDFKNKHVQELGISPTECAFNTGVYVTDLDLWRKHNITEKLEKWLVLNTQEEVYGNEKGGGGSQPPMMLVFYKKYTPLDPSWNVRNLGIGRGNMFTKSFLQQAKLLHWSGRVKPWDRSAQHSYFWDKYFIKDRTEKFVPIRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F100</accession>
    <name>A0ABY7F100_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="4">PARP</shortName>
            <ecNumber evidence="4">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_004661</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="4"/>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd01439">
        <property type="entry name" value="TCCD_inducible_PARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF4">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="6">
        <location>
            <begin position="530"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="774"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="774"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="808"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR14556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="872" mass="97243" checksum="082E73E227E4D6A0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F178</accession>
    <name>A0ABY7F178_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_005505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="35" mass="3959" checksum="D391934E6EE6B637" modified="2025-10-08" version="1">MYQAGLICRGIFSTNKTSTSASQRQRRAGDRNRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2Q4</accession>
    <name>A0ABY7F2Q4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DZIP3-like HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="42406" checksum="A59DD6B1238F96C2" modified="2025-10-08" version="1">MALSSVPVLYGKSNIEDAGHYHRLLDLFFSCTAEALRKYLEKDISSQGMTLKDFLQKEDVKKKIKGKSLFPEQKTLLHSPKPSYESFDITLLSMLILEVCNPLESVSQSVRKLKKLRNDLAHNVKGEVHGDQTFNEASQEILIIAKEIGKDFKDKILSQMRDIRNREMVRTRRNMEQIVINGEYFMVKLVESSEHEHEIKDATETKIKLNLSRWIRQLSRMDKLNIFLQNLKETCVISEMQKLSIETEYQNYSQMQRLVLFVQNETKANLFKFCKELRSMHPLLADLIEGSNTDGTDIDAYLDSNEISEIEQILRSSVKSCTGATVTCEDIHVMVEDKMKTNICFEKVKTCLLNVFPQATCNTTEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F416</accession>
    <name>A0ABY7F416_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="891"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="957"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="973"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1177" mass="130102" checksum="596D2233AC04D378" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F486</accession>
    <name>A0ABY7F486_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CALM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_031579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR16985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="163" mass="18989" checksum="0C5177571794F4BC" modified="2025-10-08" version="1">MVSNKKPKQEDGETTMDKEIRELFRLFDTNNDRSISLQELGKAMRFLGMSPSEQEITDAMSALDTNENGRIEFQEFYKFMQAEMTKLNEADFTNNQDTVRSAFRTFDKDGNGYIDEKELRIAMKKLGEALTDKELDDMMKQADVDEDGKINYEEFVKIWCETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F662</accession>
    <name>A0ABY7F662_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28353" checksum="1492D4CEB643F1BC" modified="2025-10-08" version="1">MAKELFEALADVIVCTHITGLQRVRGGNDKVAKYQSNRLDGEQTVRIRVKDISLSVDDGVILRSLKLRVKDKLTNCENGDRLYIVKSSSLSATLPKFMAFGHFTGRVFHPGQNSENKELKCKKCLETGHKTIDYENDWRCLDCHQIGHKKGECELECNPSSTPQSDIEVTPIQDSSQQAEHSEPSSPRAKKKKRKKAIKGQKPIDAFVVIGADNKDTPNKGKKPIASERSPPTPAEVLNDESKISRLKDCDTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7V7</accession>
    <name>A0ABY7F7V7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EF1G-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_000096</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="85"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="5">
        <location>
            <begin position="225"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR18258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="387" mass="44688" checksum="0B286450E20B456B" modified="2025-10-08" version="1">MNLQTLYTYPGNFRAFKALIASEYSGAKVTVDTSFKLGETNKDAAFLKKFPMGKVPAFQSSNGDCIFESNAIAQYVGNEQLQGKSRTDAALVQQWINFGDNEIIPASCTWVFPCLGITQYNKQDTEKAKEQIQKALCVLNSYLAPRTFLVGERVSQADITVACDLLLAYQYVLDPSFRGTYANVNRWFTTLINQPQFKKVIGDFKLCEKMALFDEDEDDAPRRDEKDPWINSPKTSFDFDAFKRSYSNNDTLTVALPYFWEKFDKENMSIWHCVYKYPEELKKIFMTCNLVGGFIQRIEKMRKFSFGSMCILGEDDKNQISGVWFWRGHDLAFELSPDWQIDFESYTWTKLNADDPKTKTMVQEHFAWEGDFEDLKGLKFNQGKVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8H5</accession>
    <name>A0ABY7F8H5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR17322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="72" mass="7732" checksum="623C189F644DD0EC" modified="2025-10-08" version="1">MGGGEGFSQNQKTFVQKTFYACYDVRGMLLGETCAGDFNCTYNGMVFCGHIPCPLEPCAVQLVLTAAPQTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8N1</accession>
    <name>A0ABY7F8N1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="83" mass="9397" checksum="BF0C565B9710E75A" modified="2025-10-08" version="1" fragment="single">RRIYLGSTTIGALAVLSGVLGILLICTATGCYLWNRRMSKSIEHSLEIHLDQREIERAYEQLQRKTSGETNRNIDDTYAVLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8T8</accession>
    <name>A0ABY7F8T8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NOTCH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_000426</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nephronectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MAM" evidence="8">
        <location>
            <begin position="5"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="232"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="270"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="308"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="345"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR18588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="382" mass="41412" checksum="BD59B92BD309908F" modified="2025-10-08" version="1" fragment="single">MSKDMSCNFDEDTFCSWHNEQMLDKFDWTLHRMSTASMDTGPDADHTVGTANGTYIYIETSAPRIVNETAWLVSPVMRYRGAQAQCLHFWYNMNGASVGTLNVYLQSVDGTNIPGKRVWSSIGNQGPAWRSAQVPIISDSDLKIVFEGIVGDGYVGDIALDDISFTDGSCALSSTTAPVITTTATTLLSTTSSGLMNGCESNPCIHGVCYVHQEEYFCLCHSGYGGQNCQIDQDECSSSPCKNGATCEDDVDNFVCHCKHGYAGILCETEIDECLSSPCLNGGSCLDEVNGYTCTCVQGVDGDHCENMLDPCFYNPCVNGKCFSHLSLFLCICPTHYTGKYCEISQDICASMPCLNGATCSSRVDTLTCSCSEGFDGTRCEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FA03</accession>
    <name>A0ABY7FA03_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EMAL6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_000748</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat EMAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055439">
        <property type="entry name" value="Beta-prop_EML_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005108">
        <property type="entry name" value="HELP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF33">
        <property type="entry name" value="HELP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23409">
        <property type="entry name" value="Beta-prop_EML"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03451">
        <property type="entry name" value="HELP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EML-like first beta-propeller" evidence="6">
        <location>
            <begin position="53"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="232"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="7">
        <location>
            <begin position="327"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="558"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like first beta-propeller" evidence="6">
        <location>
            <begin position="715"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="7">
        <location>
            <begin position="997"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="997"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1230"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like first beta-propeller" evidence="6">
        <location>
            <begin position="1364"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1415"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="7">
        <location>
            <begin position="1650"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1662"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1882"/>
            <end position="1917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="598"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1270"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1276"/>
            <end position="1292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR18910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1917" mass="211622" checksum="6EF8BDE402B8A279" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBY5</accession>
    <name>A0ABY7FBY5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_000965</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="790"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1032"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1032"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1053"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR19127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1083" mass="121280" checksum="4158BAF44E0C8BB5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FC41</accession>
    <name>A0ABY7FC41_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DCAF5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_000086</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF43">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="534"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="661"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="944"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="571"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="715"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="792"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="832"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="851"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="913"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="944"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="969"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="993"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1007"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1033"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR18248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1045" mass="118507" checksum="D0CBCA8F6BFD2234" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FF81</accession>
    <name>A0ABY7FF81_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C87A3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_014812</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF252">
        <property type="entry name" value="CYTOCHROME P450 26B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR20838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="400" mass="44821" checksum="0C7D2D888B99B4C4" modified="2025-10-08" version="1">MSAKVPGSAGLPLLGDRSYEFYKDPIKFQHKYMENTKSRVFLARFLNKPTIFVGSNHVVHEVLTGEFADSLRESLKQLFTEEAIETYQSTIERIVKKSLSNLDTGLAIEVCLGLFLGLDFSQPEADVIADLTITHWHGIISVPLAVKVPLMSESTYSKAMDAKRKLLEIIHQRRIDKRHEFVERVEGLGSLTEESVNNHLLLFTSALVPKALSSILTSFDFSAGGFRFPAGHGVLYMTYTAQRDRAVFEDPDTFNPDRWTHKNANDRERLYCFGMGPRKCVGQNLVSTILKTVIRELLEKYTWEMVADQDLPCKCLPVYRPRNQVLVKFKSSMGQDSGYLTSPGSPLSPACPNCKKFVMPSPQGSKEAVENEIGVRRENGTIPGCTCSCEGVSPMKRTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHA1</accession>
    <name>A0ABY7FHA1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047076753" evidence="1">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="77" mass="8567" checksum="EE8358F029BD99A3" modified="2025-10-08" version="1">MNILFATAMVCILLTNGVQAESKIQESKMEGLPVNGTSDIMPKLEVSGSGSRNEKCRYLKESVLIFYEGNNLRRTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIC6</accession>
    <name>A0ABY7FIC6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DDX58-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_014761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.30">
        <property type="entry name" value="RIG-I-like receptor, C-terminal regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038557">
        <property type="entry name" value="RLR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021673">
        <property type="entry name" value="RLR_CTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051363">
        <property type="entry name" value="RLR_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074:SF16">
        <property type="entry name" value="ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074">
        <property type="entry name" value="HELICASE WITH DEATH DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11648">
        <property type="entry name" value="RIG-I_C-RD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51789">
        <property type="entry name" value="RLR_CTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="453"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="RLR CTR" evidence="3">
        <location>
            <begin position="618"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR20787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="753" mass="86952" checksum="8DA3FFF2C2448220" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJB4</accession>
    <name>A0ABY7FJB4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="161" mass="18416" checksum="BB86A531797E06EE" modified="2025-10-08" version="1">MGKCYSTHERKQQQSTTTTDEVFIYNPSRPEPIREPPIGRVSSETNSSEMNTLENKSQHAFSEMITLEYKSQFACSEMITSEHKSQLDFSELNALEYNSQDTDRLQGLVLSTNSRLNQRYFMVNVPLASGKGDSKRNFPNDNNYTPEGGVSTDSFPLRYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJM1</accession>
    <name>A0ABY7FJM1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta-1-pyrroline-5-carboxylate synthase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Glutamate 5-kinase</fullName>
                <shortName evidence="16">GK</shortName>
                <ecNumber evidence="16">2.7.2.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Gamma-glutamyl kinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Gamma-glutamyl phosphate reductase</fullName>
                <shortName evidence="16">GPR</shortName>
                <ecNumber evidence="16">1.2.1.41</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Glutamate-5-semialdehyde dehydrogenase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="16">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MAR_015080</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">MELC-2E11</strain>
            <tissue evidence="19">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>L-glutamate + ATP = L-glutamyl 5-phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 16">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">In the N-terminal section; belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="16"/>
    <dbReference type="EC" id="1.2.1.41" evidence="16"/>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005766">
        <property type="entry name" value="P5_carboxy_syn"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01092">
        <property type="entry name" value="P5CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036429">
        <property type="entry name" value="P5C_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 16" id="KW-0521">NADP</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 16" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="18">
        <location>
            <begin position="109"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="17">
        <location>
            <begin position="397"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR036429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WAR21106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="831" mass="90470" checksum="C427679177FD5343" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKE8</accession>
    <name>A0ABY7FKE8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="5">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_016519</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="315"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="761"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="670"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="776"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="811"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="901"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="914"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="941"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1126"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1157"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR22545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1242" mass="146446" checksum="DB09123EA2370876" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FL20</accession>
    <name>A0ABY7FL20_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DOCK7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_036506</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd08696">
        <property type="entry name" value="C2_Dock-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037808">
        <property type="entry name" value="C2_Dock-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
        <property type="entry name" value="DOCK_C/D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF76">
        <property type="entry name" value="LD20667P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="5">
        <location>
            <begin position="574"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="6">
        <location>
            <begin position="1693"/>
            <end position="2106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="402"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="894"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1105"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1389"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1453"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="899"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1405"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1453"/>
            <end position="1462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR22837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2162" mass="247250" checksum="64AE4018EE46CD77" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLA3</accession>
    <name>A0ABY7FLA3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHMP3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_016098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR22124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="220" mass="24417" checksum="B02440DACBD869E1" modified="2025-10-08" version="1">MGLFGKDNTKSPKDMVNDWSHKLRKEGYVLERQIKAIQREEEKTKRQLKDSAKKGEKAACSILAKEILNSRKAVNRLYASKAHLNSISMNMKNQLATLRIAGALEKSTDVMKSMQALIKLPDIQRTMMEMSKEMMKAGIIEEMLEDTMESAFDDDEMEDAAQEEIDKVLYELTAGQLGEAPTAVTDTLPTRVSEPAAEGATAAAGSDDEDLMAKLEALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNH3</accession>
    <name>A0ABY7FNH3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_037442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR23773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="268" mass="30273" checksum="0FD6A4F2B1E0E955" modified="2025-10-08" version="1">MVHTNMTRAGHNQMEMDYMQQGNISHEHMMHEKMGHDHMMHEKMDHDHMMHEKMGHEHMIHEKMDHEHMIHGNMDHEHMMHGNMGHEHMMHGNMGHNKMHHMSPVLAMILVMVLTALLEGINYCLHLQQAARRAGFANKSKRSSSLVDGSLHVLYAVHKMLTVALSYTVMLCVMTMNAWILVAAVIGAGVGYLLLRPAVASCFPVSVPVKNVKEVKVAANDVNGTDGTEEGEMDSFLEEDDSKKANDVIHNNFPTDGLLQNYTCVETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNQ1</accession>
    <name>A0ABY7FNQ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LRP6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_016287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045426262" evidence="2">
        <location>
            <begin position="20"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="1">
        <location>
            <begin position="136"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="1">
        <location>
            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR22313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="478" mass="52960" checksum="A67E7751042DDC89" modified="2025-10-08" version="1">MERLLFNVFGFIVLSICWAQTEEGQTSGHLAISTLMYGPYTSNRHVAIAAFQTFNGSTNLSMTNYIGFSSSYRHSIMSLVADVNRKKLYAVDRYMAAIYVLSNFTADQAISSSSWSLLHTGVSRGSVKLAVDWISNNLYWSDPMYRWIAVQSLDNYGMFKILFHTNLEFPLGIAVDPNHNILFWADAGSTPKIERSTLTGANRRVIVAKGILYPTAIVVDVTSSKIFWTDAIRDTVEMATFTGLGRKIVRRLSHTFFYDIALFQDTIFVTALSLKNKNEIIIMNKTTGDLDNNRPRFYLTNPDVSLDVIAVSVVSQATQPLITDHCASNLCSDICVSGPTGYDCLCREGFLLQDGECVEDAGPVHRGLVWSTPTEICVADIRGINRHDRYIGSNKTCKYGVGNAISYVVVDSHGRKIIYADTYSVKAMNVDDMSMVLLSIGETGTCIGAKENHIGLGKYGSSHKQIALHTNWSTILTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQ09</accession>
    <name>A0ABY7FQ09_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DRPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_036475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="581"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR22806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="786" mass="85566" checksum="66586F29B8E0A7B2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRW7</accession>
    <name>A0ABY7FRW7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine-specific methyltransferase SAM-dependent domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="1">
        <location>
            <begin position="42"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR23889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="126" mass="13848" checksum="675172FE8B9B125B" modified="2025-10-08" version="1">MTEVGIHKAKISTKLGADRLLVALDVTQEAEAVEKAYLDPADNFRLEANFDHSTEDDTLSGVKLRAVSCNDQEIHIRKIVVLGEYLSCKYTDAQVGSLAEKAGLTLNRIWTDPGLHVGLFCFAKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FS24</accession>
    <name>A0ABY7FS24_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_037618</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="10">
        <location>
            <begin position="37"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR23949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="275" mass="31610" checksum="04AD88DDDCA6E158" modified="2025-10-08" version="1">MPKERVQKKSRQHGDIQKQGINFNKEFGQHILKNPLVVNSMIEKAALRPTDVVLEIGPGTGNMTVKLLEKVKKVNACEIDPRLVAELQKRVLGTPYQTKLHVIVGDVIKTELPFFDVCVANMPYQISSPFVFKLLLHRPFFRCAVLMFQREFAQRLVAKPGDKLYCRLSVNTQLLARVDHLMKEWDGLVRICFSRKNKTIGASFKFTKVLEMLEKNYRVHCSMKNVAIPTDFDVKAKVTDLLEKNGYELKRPRSMDIDDFLGLLNCFNEEGIHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FS56</accession>
    <name>A0ABY7FS56_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MAR_037225</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">MELC-2E11</strain>
            <tissue evidence="19">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd06705">
        <property type="entry name" value="PDZ_MAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05609">
        <property type="entry name" value="STKc_MAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.20">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037711">
        <property type="entry name" value="MAST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015022">
        <property type="entry name" value="MAST_pre-PK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023142">
        <property type="entry name" value="MAST_pre-PK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF414">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08926">
        <property type="entry name" value="DUF1908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140482">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="159"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="18">
        <location>
            <begin position="434"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="17">
        <location>
            <begin position="722"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="454"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="534"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="652"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="813"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="907"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="570"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="605"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="818"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="843"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="862"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="907"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="921"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="939"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="953"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1002"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1052"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WAR23556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1082" mass="120721" checksum="70C1F6A064370178" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FT00</accession>
    <name>A0ABY7FT00_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PON1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_037525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paraoxonase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002640">
        <property type="entry name" value="Arylesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF12">
        <property type="entry name" value="PARAOXONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01731">
        <property type="entry name" value="Arylesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR23856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="303" mass="34275" checksum="C90B9A4062D7B881" modified="2025-10-08" version="1" fragment="single">DWADFSRKIIPKVRPGQCQFARKEGGTEDLTYIGDGIFLASGGFEWEGDVGKILSINVSGDKSVMTPLAIRDAPNIDGFMVRNHGISAWRDPESGTLYLYVLTHPKPVTSSTDRVEVFEVVQKGLHLRYIRTIVDPSFTFMNDLVAVGRDQFYITRYNWFRSTWWIRFAHWFHIREGAILFYDGQHVVRAVPDSYFLSNEQTEYVDSGVDNIEVDQETGDLWIGSHPVTHRIVDIFGWFGKLPAAQVLRIKIRDGVMTSLEEIYADDGDELMASTVAAYGAGKLVIGSVFKQTVVCDVNYLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTD9</accession>
    <name>A0ABY7FTD9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="87" mass="9641" checksum="ECB9AE047FF6052E" modified="2025-10-08" version="1">MTSAQQFAAYGSKCEGFLPTKESTILVPPSSLTLMYSAALGGGQGRELDEAVTRYLGRNARQEEKDRNITRNNQPTVKKRTPEIHDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUI4</accession>
    <name>A0ABY7FUI4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PNBA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_038198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="347" mass="38991" checksum="B9FCB78D405D2F34" modified="2025-10-08" version="1">MSLDMLRYGSHTNTSGNYGFMDMLTGLHWMQNNIRQFGGDPNKIMFFGQSSGGTAIYALLASPLGHGLFHMAWAISGSPVMNKTAAEVDVDNQVVVQNTGCQDEDCLYNMTPEIVPWEEFPYWAMSDLTGIPAKDRFNGALPVVDGTTSHEESLESSPQEVTNWTWEDNKYQEYVRHALLPFGDVIAETALKLYPENVHNPEFQLASLVTDLRVTCGNDYLALVMATSFTSPVFRYIAEYAPSAPMKAFWVTLPARYAFHGIDMFAFYKTTGLMIDNMTDTDRQWEVNVQQEVLSFMQIGRPFTAYLGMFPGQTAVLSENTTVTAGYHTAECLFWLKNGFFSYTLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUY2</accession>
    <name>A0ABY7FUY2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TMP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_038536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="425" mass="49128" checksum="2AEACE5FBCF36AF9" modified="2025-10-08" version="1">MAENVQSYPYIMAGIVQSYPYIITETVQSYPYIITETVQSFPYIMAGIVQSFPYIITETFCPYIITKIVQSFPYIITKIVQSCPFILAETVQSFPYIITETVQSFPYIMAWIVQSFPYIITETVQSYPCIMAGIVLSCPYIITETVQSYPYIMAGIVQSFPYIITETVQSYPYIKAWIVQSFPYIITETVQSYPYIMAWIVLSCPYIITETVQSFPYLMAWIVLSCPYIITETVQSYPYIKAWIVQSFPYIITETVQSYPYIMAGIVLSCPYIITETVQSYPYIMAWIVLSCPYIITETVQSYPYIKAWIVQSFPYIITETVQSYPYIMAGIVLSCPYIITETVQSYLYIMAGIVQSFPYIIIETVQSYPYIKAWIVQSFPYIITETVQSYPYIMAWIVLSCPYIITETVQSCPYIITETVQFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVI6</accession>
    <name>A0ABY7FVI6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GLB3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_011934</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47217">
        <property type="entry name" value="GLOBIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47217:SF1">
        <property type="entry name" value="GLOBIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="10"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR26230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="162" mass="18474" checksum="4952580DC8801A77" modified="2025-10-08" version="1">MDDIVDPGTGLTERQKTAVRESWAKMGTNDIVEFFCRLFKTFPYTRAYFKTLDGIDQDALKTSSKLRAHSINFKHGVSSFIDNLDDIECLVILIQKVTENHFRRNIKRKSFEEAFPLFTTLVGDVQEADEFTLNAWKDTLATVLSVITEHIKTLEAQTVGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWH6</accession>
    <name>A0ABY7FWH6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">inx</name>
        <name evidence="11" type="ORF">MAR_037200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR23531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="415" mass="48694" checksum="32AEE5B69CF886D4" modified="2025-10-08" version="1">MEFNKKESLIAQITTRFKTIKGHNNDDAIDRLSHVYTSVSLVIIAIFLTTAHFVGKPIHCWNPAHYDKDWYKGYIENYCWISNTYHVAFHDQLPEGIEERTDREITYYQWVPLILLFQAFLFKIPNIIWRLLHSHAGVSLHNMVDLAEKTQGTSPKDRQDTIQTLADIIDHWLKTERSWKDNRYTRMRDAMSQKCSLMCSKRGGNFLAGLYVIVKLLFFANVVAQFFILNAFMASNYNMYGFEVLHKLSDNTPWDNSPRFPLVTFCDFQIRQLQNIVRYSLQCVLPINLFNEKFFIFLWFWFFIMGIASLYSLVKTLVVVVDNGSRYQFVKKYLKIDNKIQSGLDRKVCRRFADQYLREDGVFVLRVITSNSTDLVTTDLVSELWRKFNTEEEKASANQSSNGLRDDFTDIKANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXN3</accession>
    <name>A0ABY7FXN3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CGAS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_011618</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mab-21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046903">
        <property type="entry name" value="Mab-21-like_nuc_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF69">
        <property type="entry name" value="MAB-21-LIKE HHH_H2TH-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03281">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mab-21-like nucleotidyltransferase" evidence="2">
        <location>
            <begin position="179"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="3">
        <location>
            <begin position="259"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR25914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="637" mass="72519" checksum="110B73BA448C896D" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0U0</accession>
    <name>A0ABY7G0U0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012318</name>
        <name evidence="3" type="ORF">MAR_012320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR26616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="97" mass="11508" checksum="3E74512DADDEE4BD" modified="2025-10-08" version="1">MRIQMSNKMTGLMRLLWRRTQRYPIRQMRSNSLLKAEDTEKDNLQDDRTEATAVEEDAKSEDQLIAEIMREDFLAERKAKARRCLARRCNQDTMDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G179</accession>
    <name>A0ABY7G179_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TAF6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_013351</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAF6 C-terminal HEAT repeat" evidence="7">
        <location>
            <begin position="169"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR27647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="489" mass="52928" checksum="ACD2A22D34FBE467" modified="2025-10-08" version="1">MAEKGDKDTKMNGHLTAESVKTMGESIGEATRIMHHSKKCKLTCGDFDNALRVHNVEPLYGFHAPDLIPFRYASGGGRELHFVEEKELDLSEIINSTLPKVPLDVSMKGATTILQGDHRSMCRLRRDQALRGPPVKVNIVQNNLALLIYLMRLMKALMENQTIYLEKYLCMRPDVDNHWALRDFAARLNALICKNFHNNVNNIQARVTKTFSKAVRSEKAALATIYGALSGLGELGPEVVHSFVVPNIRMIGDRVRQAIDGQQLTNNADRIAAENIKKLAAKYISPVLKTHRLLTDTIEDYTAEYGYLGPLLHAAVGKERSSSTSSQGPPHKPTIQISQGKPHIFLGGSGTLSTPQTPTSARPLQNITFPRTPSIPGVGQNPNQKFVIMQQPRVSSVPMQTTGVGVGGTSIVKVLPGMHGGSTGNITSGVSASTITSSGSTGGQKIVVMSGSQQPMQVQVSSGGEPGRQVFTSATGEQISIVKTEPSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3Z2</accession>
    <name>A0ABY7G3Z2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CNGB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_002741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR29173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="303" mass="29096" checksum="FB1486C2108453DA" modified="2025-10-08" version="1" fragment="single">KKSLSLGSVLSTVAIVIGSILFAIILAVGFRVWKLVKKRGAVYGTHYADTVGGIHDAGEVVGGHNEDTVGGFYDAGEVGGAHNAGPVGGFHDAVGGANKSSAVGGAYNVGAVVVTHNASAVDGAHYVCAVVGAPNAGEVYDAYNAGAVGGVHNVDAVGGADSSGEVGGAHNTAEVGGANNAGEVGGAHNTGEVDGAHNTGEVGGANTAGAVGGTHNACAFCCAHSTGAVGGAHNTGAVGGAHNTGAVGGAHNTGTVDGANNAGSTGHILNGNADNAGAIVSNIDTNRDLETAKNLKDNDCFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4M5</accession>
    <name>A0ABY7G4M5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FOLH1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="628" mass="69805" checksum="B920A72016696B50" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6H0</accession>
    <name>A0ABY7G6H0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_003105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR29537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="273" mass="30069" checksum="D74444C93B7B3344" modified="2025-10-08" version="1">MLRSQQFFDFTSSNCSAGIDKNNLILAQGAKAGSVYWKYLALQTPGQDAQNLFEPGCRFVVLDLGGGTVHFTAYEVDSDESLSAILKPCGEDWGGNMVNAAYIEMLWRIFGKDMVEKFQQDNQEDFLDIQNEFESKKREFTEAGQTVHLKLPNSVVLVVEKHSTVSSLIGKAGLDDDVDFASGKLSVSGKMFSEFFKKTTKDIVRSLQHLLDSAEVHNSIDKLLLVGGFSQSPVVRNAVQDAFPLIPIYCPEDAELAILKGAVILGHKPKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G724</accession>
    <name>A0ABY7G724_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CADN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR30228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="195" mass="21314" checksum="6050D5191A927483" modified="2025-10-08" version="1" fragment="single">WGQWSGCDVSCGNGTRSRARSCDNPAPAQGGDDCVGPKHDQDVCVLQTCPAIIVYCMFSGKQCESANLLLINDRSLETSEFTRFRLLSNKQTGDVYKKIYFVDGWNSWSTWSSCSVTCGQGLKHRHRTCNETIGTTLGGGCIGNDQEYAECYITICDTIVLFYAHGPRDLAISTNEKVVYGTITTNKGGGYNSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7B4</accession>
    <name>A0ABY7G7B4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TSP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF21">
        <property type="entry name" value="SEMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR29822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="140" mass="16124" checksum="028FEFE6D7F3F57D" modified="2025-10-08" version="1">MVNIHVTAHAPIQLQHTVDKTVLAFVRAMFILLQYRFMYKEETTVSYHCLLEKYTRRNIHRGWSFWSSWGSCSVTCDVGMMRRDRSCSNPYPGIHGNPCFGDARDDAICKEMASKNIFPLNILISYMSYVALSSGYNNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9Q9</accession>
    <name>A0ABY7G9Q9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_033687</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF475">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="240"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR31145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="393" mass="44596" checksum="F55ED86D43EF9753" modified="2025-10-08" version="1">MAQEVFCCCEYENRQGERSHLLACCCDCEALDQIADRCFKCESIPPSLIDNFLDTLGDRCRIPGITGGGALRVNLELATPLVVIPTSLILASIGPITTFCVLLFLPCFCAFFYSTWKRRTNKLRTKFFFIWGLVSLVFMYILFELVICGYTRVSYSDNILMTVAVIGMLVALKFAKQDPGVLVEDKREKYMQDSYGFFGVYTNTEEQKAEDEDFEVIQMEDVMNEEETDAVIKGDHPLSKGDNWCVKCELQKPPRSGHCNVCDVCIADRDHHCVWIDSCVGRKNHRSFLVAMVMFVFVGCYGSYVTLAAVWGLCYASAWYTLLVCCIMAVGLVHQIVLISQNATSQEVHRASQTGNTCWAIFIHKNSRNNGLIQNWRDFVLYKRSSRSEYETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GB35</accession>
    <name>A0ABY7GB35_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FIBA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_003749</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF7">
        <property type="entry name" value="FIBRINOGEN BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR30181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="102" mass="11706" checksum="1491CC3DD9A4E025" modified="2025-10-08" version="1">MERGAGQYIPIAQLPGIVNVNQPGSLYPYHNGMLFSTFDHDHDHWHYSNCAVLEHGAWWYNDCYYANLNGQYDVPGTHNPLGMTYDAFMGTVSLKESKMMFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GDB5</accession>
    <name>A0ABY7GDB5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GCY28-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_034086</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052612">
        <property type="entry name" value="ANP_Clearance_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001170">
        <property type="entry name" value="ANPR/GUC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755:SF11">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755">
        <property type="entry name" value="NATRIURETIC PEPTIDE RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00255">
        <property type="entry name" value="NATPEPTIDER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="8">
        <location>
            <begin position="15"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR31544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="204" mass="23908" checksum="574F6313025CF526" modified="2025-10-08" version="1">MVLLTKSMASLPFGEYVFIFFFQLHGDPPVGTYDWFRGDTLDNEARLAYESVMVIRPRRPVSDEFFKFEKEVKERAQTEYNYTWREGNEVSIYNIGHYDSFILYAHTLNESLAAGENPRDGKRIVKRMWNRTFPGIGGPVFVNENGDRDTDFTLLDLDPITGKFRVHFCFHRRSTVPRLDPHVRDNQRCPRTLARQNYSPTQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GE60</accession>
    <name>A0ABY7GE60_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CPO-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_003054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR29486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="193" mass="21241" checksum="53843D1D55C78EC2" modified="2025-10-08" version="1" fragment="single">QVRTLFVSGLPMDAKPRELYLLFRSYKPVGFVTFSSRVAAEAAKQDLQGVRFDPDLPQTLRLEFAKSNTKVTKPKQQSPQPATHPTLIHPLTGHMNMLQALQAQAGSPIGYEMHPGMMAAGQVSTMNHPMLGATPIFSSPLMGALPQEVKEANEAMSRLQGFVLLSSDRGGIRIEYAKHKMGEIISGQQREKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GEU9</accession>
    <name>A0ABY7GEU9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative nuclease HARBI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Harbinger transposase-derived nuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_034396</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transposase-derived protein that may have nuclease activity. Does not have transposase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF286">
        <property type="entry name" value="NUCLEASE HARBI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="13">
        <location>
            <begin position="122"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR31854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="334" mass="38035" checksum="4ADE6B266134D082" modified="2025-10-08" version="1">MAANNHQPNVLDIYNGRQLLERYRLDREGIEFLEAELNQFIATRNRSMTVTEKILITLRYLATGGIQLNDGDIHYYAKLLMRWHNPQLSRQYLKFPLTPQTLHDTKSDFYGIAGFPNVIGVIDGTHVQIKAPLQDEPAYVNRMGYHSINTQIVFDGRDNIIDIVARWPRATPDSRMLRESGLHALFLGGLVPGDHSYLLGDSGYPCKKWLLTPYVNPQPGAQTRYNSAHKTTRSRVEGGIGQLKRRWGILNGEIRLKPEKACRVIIACAVLHNICKRRNIPLLDILPNAAGQGMNQGVYAGPQEGLRYREFVAQSFFLNVVEMQYRLVSPYLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D9I8</accession>
    <name>A0ABY7D9I8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FBP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_006792</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="170"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="208"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="263"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ94321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="320" mass="34453" checksum="3E43CE6FF2734526" modified="2025-10-08" version="1">MEPHVWATLTAIGATVVQDSTALSVKSKSLQILLNLKQLGFISRSTDTDRKDVNECASLPCANGVCIDQIQTSAYHHLANMVAFAWTMSGSLYAFVLRDTREPAAKQRRTSVPPIHAGTTDYVQTFFCNSTVPVLRVLPDDSVKMGQEVKGKFYIIKSTLKYETIVVTTIISACSSAPCRNGGLCNNVPGGYICTCNPGYTGQTCGIVIDECTSQPCLHGAICQNHINGFECVCATGYEGTISAHGFDPSILMNFTVALVLTETDECTPDPCQNGGTCVDLVAAFRCRCVSGYTGTFCETAPIFGASLHTQHRTMVDNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAR2</accession>
    <name>A0ABY7DAR2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLSP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_007227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF4">
        <property type="entry name" value="CHORION PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ94756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="165" mass="19173" checksum="238536113B4EB86E" modified="2025-10-08" version="1" fragment="single">MVFQLRSRICSFSNCRLHEKYVESTIITTNVSSDRLFEAGTRNKLFMDEMKNSLDLPALNIQRGRDHGIPPYNHWRNHCRFEKAKMDKDGFVLPDHTEKQTKLLQEAYSHVDDIDLFAGAMTETLLPGSSVGPTFACLIGRQFQRIMEGDRYWHETSNKITRFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCU8</accession>
    <name>A0ABY7DCU8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SPAG6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23314:SF0">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23314">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 6 ARMADILLO REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ93913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="508" mass="55062" checksum="567519FF25251785" modified="2025-10-08" version="1">MSQRQVLQVFEQYQKARTQFVQTVAELASRPQNIETLQNAGVMSLLRPLLLDIVPTIQQTAALALGRLANYNDDLAEAVVKGDILPQLVYSLAEQNRFYKKAAAFVLRAVAKHSPQLAQSVVDCGALDALVICLEEFDPGVKEAAAWALGYIARHNAELAQAVVDAGAVPLLVLCIQEPELSLKRIAASALSDICKHSPELAQTVVDAGAIAHLAQMILNPDAKLKRQVFSALSQISKHSVDLAEMVVEAEIFPAVLTCLKDPDEYVKKNVATLIREIAKHTPELSQLIVNAGGVAAVVDYVGESKGNVRLPGIMMLGYVAAHSENLAMAVIVSKGVVQLAIALSEEPEDHVQAAAAWSLGQIGRHTPEHAKAVAVANVLPKLLQCYLRADASEDLQTKSKKALKNILQKCVHLPALEPLLHDAPPNILKHVVGQFSKVLPHDSKARRLFVTSAGLKKIQEIKAEPGSALAEYVNTINNCYPEEIVKYYSPGYSDALLERVEQFNPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHW7</accession>
    <name>A0ABY7DHW7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_028891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ96201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="63" mass="7206" checksum="118556FB94A708F1" modified="2025-10-08" version="1">MVKVHAIVLEILAQLTTRSDVTVEWDKTLRYIYPRSTVLLLISSTVDSSPKLNVETTFEKDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIS5</accession>
    <name>A0ABY7DIS5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_029914</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="7">
        <location>
            <begin position="60"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ97224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="260" mass="29037" checksum="5A8D2125DB8467B3" modified="2025-10-08" version="1">MAAPVCHVSAVKHITRRFLSCSVALQKTGLKKSKGNQSSNNWLQRQLNDPYVKSAQTEHFRCRSAFKLLEINDRFKIIRPGDTVIDCGAAPGSWSQVAARAINKKDGNTMDGMKGSQTRQNDRDGMVIGVDLQEVEPIEGVLMFSGHDFTSPDTQHKILNTLDNMYANVVLSDMAPSASGNKAFDHERISKLCLSVLKFSSQVLANDGHVVCKLWDGSERKDLLKVMERMFRTVKVIKPDASRSDSAEIFLLGMEFYLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJ19</accession>
    <name>A0ABY7DJ19_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CP3A4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_029030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ96340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="420" mass="48121" checksum="AF38F98340486E84" modified="2025-10-08" version="1" fragment="single">GQLEAMCSWERQYGRVFGYYEGWTPVISVADPDILREILVKDFNNYRSRKPFPLAPRKSLGLFLENGDQWKRSRASLTPAFSTGKLRQMFSQINDSVDHLVCNTEGKCGESFDIYNLYQRLTLDVIGRCAFGLQTNVQTDENDDFLLNIRVLFDGLSKTIIQPLVMLVPFFSHFLFALKNLVFLFGMNPVMRLRNQMREVVRVRKQMGHENIMPDLVQLMVFPNCEGSKSTRKNIEPMSDREIVAQSMTFLLAGYETTSAVLAFLTHALATNDDVQNKLCEEVDEVLKSKEVTYEMVNKMPFFDTVIDEVCRLYPTASMIVTRVGAKERVYNGVRLPAGMAIQGNVWALHRDPELWEEPEEFRPERFSAENKPNIKPYSYLPFGAGPRMCIGMRFALLEIKVAVGRILQNFTFAKSCETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKZ1</accession>
    <name>A0ABY7DKZ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047273385" evidence="1">
        <location>
            <begin position="20"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="156" mass="17519" checksum="E95FCEFA4B292614" modified="2025-10-08" version="1">MMNKISLCLFIFMNLTVLSRESHVSFKRRVITIYIVSSDCNIPVDDVTITCQTGARVRMRSMGTGNYQILTRKLPLRLQLSKSGFITKTVIVKVKNLTVHLCLVEQLGVTSPTASPLYNPPSNSLEGKYRFAAVAADNDECSKIGKYEFTSHFHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DL11</accession>
    <name>A0ABY7DL11_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NRP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_022774</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF50">
        <property type="entry name" value="ATTRACTIN-LIKE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="29"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ98401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="100" mass="11318" checksum="5A39041BF61B6B20" modified="2025-10-08" version="1">MLNITLNITMYMCVVFFIITEIVVNVTSTSNIVWLQGMSGNVSSPNFPRNYPNNFNCTYYINGPQLSTVCIQFDDFLTEHCCDYVRVFDGPPDASRSIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DL16</accession>
    <name>A0ABY7DL16_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TMM26-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168">
        <property type="entry name" value="TMEM26 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="413" mass="46717" checksum="CF35686C6868DD12" modified="2025-10-08" version="1">MLRLRVMDGRLRLFDTGNSKAPSTEKTESRGPLAAALFVRAVFILHNLLSVWRVVVTKKDDRYWALVAANIFTLVEAFLVVKWRRGIEWKWCPCFLAYLVSTFPAIWLLQLTQYQNAVIGPSNNGTNVTAGYQALADPQNATTDVYMNYSYNENVTSTTAIIATELVSNTTSSILDRLEGLLQLGEQTWIVVIQESLVYLIIFGRWMLPRAHTSRADLSDLLLEYLAIASDTMELYALYDEDAVQADLGITYAILALWSISFLQFVPILKNKSKFKHLQSKRTKRIQEACGDYFAEVFVTCMSVMLQDGPFLCLRLYIMLYLNLVTYSLVFFIIKNIVTIILLLYRLSILCLKLPCCYGSDGDVEAVEAVDFSRAIHMQHDTGIRIATPNGLAHRTFGSLPERSYMNGTGIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQM0</accession>
    <name>A0ABY7DQM0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1054" mass="119401" checksum="569D2A6413916090" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRL4</accession>
    <name>A0ABY7DRL4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="123" mass="13148" checksum="46DC90ADB8C7F800" modified="2025-10-08" version="1">MASSSPPKEKVGTPGSSASGTSRFDNMGSSPNIRARGPHDHDVMSSSMCAVSRPARSDDLMSQSMSAAGSHGEANLDSLLAGRPHRMDEVMSASMSAVDRRKMSADHRRHWDDDMAGIQAEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRQ1</accession>
    <name>A0ABY7DRQ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">E74EA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_023765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF10">
        <property type="entry name" value="ETS-RELATED TRANSCRIPTION FACTOR ELF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="137"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ99392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="213" mass="23977" checksum="957BC7B65DBA6B73" modified="2025-10-08" version="1">MESPSAGTESKTFLQGLLHQHANSNAVLPPSPADSDSGVSSDLESPDDKLRLQAYLASQHSSGCDASKEHYLAPFCQPPPAHQPLPAHFNTATHVAMRPDVYKGQQSPGQHAGRKPKFQEYQAQMSTPKRKRESSTTYLWEFLLQLLQNRETCPRYIKWTNREKGIFKLVDSKAVSKLYYYARGILNKVDGQRLVYQFADVPKQIIEIDCTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRX4</accession>
    <name>A0ABY7DRX4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SHFL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_024827</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoplasmic ribonucleoprotein granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SHFL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026795">
        <property type="entry name" value="SHFL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16135">
        <property type="entry name" value="REPRESSOR OF YIELD OF DENV PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16135:SF2">
        <property type="entry name" value="SHIFTLESS ANTIVIRAL INHIBITOR OF RIBOSOMAL FRAMESHIFTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15135">
        <property type="entry name" value="UPF0515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR00455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="297" mass="33399" checksum="3D2538E483F44B59" modified="2025-10-08" version="1" fragment="single">MAMADGSPPTHDADWERIKALRRFRELFHGRFTDAEGNIIMRHTGWSAEAAVGFVLQASQDDINSILDENSVVTRVRRNTVLRDIARRNEVGAEIRQFTCQECDNMWWRKVPTRKPVARCHLCREKFDPLARNKEFGLAKFVCACGNAFRAFGAMDVSALGHNMLGKSKCMCYSCMQNLCEPVEILPPFKGREREDGRARHRYTHKCTAYNCYKRYNPLPGEPVVPVCVHPNSLEHKVIEPSSGHVSTGSTVKTFLTQDELAPPHAPYEPSLASIPDFSDDDNANVNSPEAAMSSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSA8</accession>
    <name>A0ABY7DSA8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="139" mass="15500" checksum="545C1F55278776DD" modified="2025-10-08" version="1">MSYEYTGQDKIEMNSSNIKAATAALVLCIVVTASALPAELEGLLLDSDFQKPDPCSVCYIFGDEESCTVCKLDMASMTKRSGSIFHPLFRGTFPKKSTYAQYYNPLSRGSYHKKSPYPVYHPFLRGGYTNPYLNTVNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DSN4</accession>
    <name>A0ABY7DSN4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CNBD2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_023994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011:SF28">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="91"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ99621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="363" mass="41779" checksum="69EE94A80949E18D" modified="2025-10-08" version="1">MPGMRTFMDIANEESTTEENMKNAGLSFDPNYFKAIREISLSSETKNILTTSPDRRTPEHVQTAMFGLQCLRSYAEYPLHMQEKLAKVAWYEVVAPKRIIIRQGHFAENFYFILSGHAVVTILLKNPKTGATFVKTATIMKKGMSFGELALLHHSKRTATVTSQDTVQLLSIGREDFFDIFMSVDGDDNMPHHIRFVSNLDFMKDWPIEELIEHPEHCLLHFFKRNTTIVANSNNSEWLYIVKSGSSPKVDSGLRSKPNSTKEEDKDKKGLDSLRFEGDVQRAHTSVSLVSRGAECIMLSKDFFVKHVNTAVRMRHRETVQQYPEEKIFQDNLQIKEDWTAYRKVLLNDITSRIKENSNRFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTQ5</accession>
    <name>A0ABY7DTQ5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="23212" checksum="ACD2057659CB72D3" modified="2025-10-08" version="1">MQIIGAQMDSKTCQTNVENINTTITLVGEEIKEAIQETSRKISEGTRTTADKIDELKEHMNKIKITKDSPIPSPAPSPTPVSNRKSKGEEEEEEKGEEGDLSKGQEVLARWSDDGWYYFGLIESKEESKDVSRGKSKKQKEDAILWKVRDSTGHSENIPRRNILTEEERKQRKIEVRLQTLEISFLEFIYWRMKQKIRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUW8</accession>
    <name>A0ABY7DUW8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SREC2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_023093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="33"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ98720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="344" mass="38361" checksum="CFF95F9F19F7F2C0" modified="2025-10-08" version="1">MCEELKRVIVFLILNIFTNVLVLATGNQVKGSANQSSQYRTCSAEKAFDGETIFHESESRCTCSATAVRQIPRWWEMNFGSKHLIGSIKVIGRDGFGREQSQSLAAYISNDTMETNSGTVVHLPDSNTIGLIVQFNHAPRVAQYINIKKDGANDVMTICEVEVFGAKCPSGYFGDMCVRRCHCKNQCEVISGHCTECEPGWKPPTCETECPTGRYGDYCSRNCSQHCIAEECHRVNGMCNHGCKPGYNFQIDPKCETHYKEERMFTVYEVAGVAGVSVAGCLLLLGLVFACILGYRRYKSASKERDTTNVIPDIDYVNTGRAYEGPNEVQLQNSDEHIYQTIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DW66</accession>
    <name>A0ABY7DW66_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RBM19-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_008528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd12564">
        <property type="entry name" value="RRM1_RBM19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12567">
        <property type="entry name" value="RRM3_RBM19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12318">
        <property type="entry name" value="RRM5_RBM19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034419">
        <property type="entry name" value="RBM19_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034423">
        <property type="entry name" value="RBM19_RRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034418">
        <property type="entry name" value="RMB19_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="353"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="600"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="539"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="682"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="539"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="556"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="682"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR01970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="798" mass="90117" checksum="26546ABBD0C108B5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DYV6</accession>
    <name>A0ABY7DYV6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CADN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_024458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF21">
        <property type="entry name" value="SEMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="364"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR00086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="612" mass="68309" checksum="5E6F31B8491F9E53" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0A5</accession>
    <name>A0ABY7E0A5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TM53A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_008919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908">
        <property type="entry name" value="LD15586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908:SF4">
        <property type="entry name" value="SI:DKEY-5I3.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR02361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="344" mass="39831" checksum="1ACD98558E261F9A" modified="2025-10-08" version="1">MSSRKGLILCLKCPKSSLFLNHRGLRTSACALTTHGRGHDGPRVSHHPIGLPRFTHRPIDKNLSITHHRHHNEADSGHAREPRPLVLLFAWLFAKPSHLKKYCDFYLEHGFDVLTARLTVSELLRPKKVQSVMTNVLDLCHEGPRQEQPLLCHAFSVGGYMYGELLTNLARDMEKYPEFGRRMFGKIFDSPIDYYGVPKGVARAITNDKEKSQRIEKSVHWYLEKFRPITHQYIRASDNVHANEMKTPGLFLYSLNDPLCNPEHIETLAKTWRLNGIEAETAFWKRAPHVTSFKMYPDEYKSHVIDFIWRTGIPGHRMPRIQPPVQEEPEEDFREQQILKMALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0U8</accession>
    <name>A0ABY7E0U8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BOLA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="63" mass="7437" checksum="E651E9FDE4E6CF4A" modified="2025-10-08" version="1">MPISAKELEEKLKNEIQATHLFEGKPLIQRHRLVHSTLEEELKDIHAFSMKTLTPEQWQKQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E0X2</accession>
    <name>A0ABY7E0X2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SCRB2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_025178</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005428">
        <property type="entry name" value="CD36/SCARB1/SNMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF51">
        <property type="entry name" value="LYSOSOME MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01610">
        <property type="entry name" value="CD36ANTIGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR00806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="382" mass="42898" checksum="2C1FA0430A9C78BE" modified="2025-10-08" version="1">MKKASCCLIWATIIGVILLIAGIVVIPVAKNLIHNKITEQITLKSNATYQNWVKNPTPIFFQLWVWDLQNPDEVKNGGKPSLVQRGPYSYRENRHKINVSFHDENDTVTYKEDKYYVFDRAMSNGTEDDKFTTVNIPLMKIADALIEWGEKDVFMTLSVKDLVWGYDEPLINKTVTLLQELGLPIHIDDHFGLFVGQGIDLYRFSTPPDVFMSHIDNPANQGYCTPSDNCLPSGLLNMENCHDGAPLVFSQPHFLNADKAVINGVYGMHPNIEEHGTFIDIEPNTGAAFYAAKKLQANIALERVPNIKSTLKLPTVVLPVVWLNESSKITKSLADEFKSELQTPLLVIHVGTYLAIGLGAFLVLMSLTVAIFRKLREKQKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1L7</accession>
    <name>A0ABY7E1L7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">E78C-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_009281</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001728">
        <property type="entry name" value="ThyrH_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805:SF10">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 78C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00546">
        <property type="entry name" value="THYROIDHORMR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NR LBD" evidence="11">
        <location>
            <begin position="42"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR02723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="305" mass="34745" checksum="10F24516F221AE92" modified="2025-10-08" version="1">MEEAQVSSTDPCLDQTSLESKQLAIYDIILSVSQGHLANCGITDDKLKTLHRHHSTLMTKIEIPDQPVQFTDDELEKQRLLMWQCYAHLTTPAIQSMVEFVKRIPGILDLAQDDQLILIKTSFFEMWVTRMARMFNPEDFSLTFEDGSIIQKDELAVVYSPEFVSAMFDVAGNINGLNLNDTEIGLLSAVILSTPDRHDVKDQKAVEALWDRLIEALKLQLKRNHSTEENLFGTALVKLSELRTLGSHHNELLKYYRANWHRCVIPPLFSEIYDIPKNEQQFPPPPPPPPPHYDQGSSNTNIPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E423</accession>
    <name>A0ABY7E423_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_019944</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045268543" description="Ig-like domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="712"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="470"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR04575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="803" mass="90643" checksum="6407BC1BEA2A1FA1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4X8</accession>
    <name>A0ABY7E4X8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NEMP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_019608</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019358">
        <property type="entry name" value="NEMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13598">
        <property type="entry name" value="AT07567P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13598:SF1">
        <property type="entry name" value="AT07567P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10225">
        <property type="entry name" value="NEMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046683303" evidence="10">
        <location>
            <begin position="23"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR04239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="407" mass="46920" checksum="DC21942F9639709A" modified="2025-10-08" version="1">MEENYKITIFALLVYCLVPVLANENVKNDCKKAKNCYWLLINDIHSRKPTPPSTLFCFEGMQKNVLYMWSNPMLRVTRNLSNANETSKFITYYDLSAADVESKSQQPGYSILMGWFSSVRALQQNEDMAFSAFNTSCFKIDSNIDFTAKLFIKTTRCFTTAQVYRLACSLLFLFLSLYSPKYSQRLKNLIYFMFFLSASASVYFINQFANYMSNPITGTLAENWQYIVGYILLSGLISFALVYRYGPVENERTMSLIQWFLQGVGLALVYNSTQLTEVSCALVIILLAVYNFPTVVFTNQRTKNIWFRIFPPKVKLLTEDEYVRQGNEATQAELAKLRDYCRSPDCQAWKVISRLKNPHRFAEFVEGNSWHVNDEELLEYDSGPDPTPPHLADDSDIEEMDFQLSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6B5</accession>
    <name>A0ABY7E6B5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Novel STAND NTPase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049050">
        <property type="entry name" value="nSTAND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20720">
        <property type="entry name" value="nSTAND3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Novel STAND NTPase 3" evidence="1">
        <location>
            <begin position="21"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="362" mass="41931" checksum="172B8C0FCEE1F173" modified="2025-10-08" version="1">MKSLRENTIWFFDESRKDVFYVETARFQDAIRLLKEKHFIVLTGHPGEGKTAMAARLALADGTKPENCLKLERARDWRKVDWSLKLFNTVIVDDIFGGGALNQKLLGDWEPYLPEMERAAKQKRLRIIITTRHYIKEEALEELDKPTMFDDKEGYVLLLSSTKYMTFDEKKDILVSRAKKNNSEDMINAHRKKYEDCVKKAEGLYKGKDEEQFHKFLALVIVWAKQDMRMKEHDLQNAKKVSDHVKYVANCFGIDVTNSFLEILKSSLKSHVHDLFLLIDHSGEYTFSHNVNGDMVGVVIGSHKPLECIELCPRDFLMERVTIAQAGKDELRVVVKQSDYEALCEKLAKMICRKDCNLMAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9D6</accession>
    <name>A0ABY7E9D6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P4HA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_020575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="7">
        <location>
            <begin position="319"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR05206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="513" mass="58417" checksum="11E0ACDBD7022AFB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9D7</accession>
    <name>A0ABY7E9D7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_022006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="28" mass="3406" checksum="3354280A2E9364F0" modified="2025-10-08" version="1">MVTIKLSVYHVMNRSTWTHLMSSWQLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAP5</accession>
    <name>A0ABY7EAP5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="150" mass="17300" checksum="CDE5CC1810BCFC87" modified="2025-10-08" version="1" fragment="single">MACDKQHRVTRMALPVWRYLYSVCLTASRYPYGVTLRYPYDLGLTAVRYPYGLCLTASRYPYSVCQTTSRYPYSVCLTAVRYPYGLGLTAVRYPYCLGLTAVRYPYDLDLTAVRYPYGLCLTASRYPYSVCQTASRYPYSVCLTAVRFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBD2</accession>
    <name>A0ABY7EBD2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_021798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR06429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="264" mass="28979" checksum="3665C6E638402158" modified="2025-10-08" version="1">MLFGYVDIAPVSRTPRTNESFTITCVTNGSESLTWLKDGVFLSSCPTESPECFPPKMDSYLFLSNVGSKTFDLTITSVSLQSCGRYTCSDKSERNKDSVTLTVVQFENDSISPITEPDLGSDGNITILTDCVFPTSVYSQWSIVRDGEEIDNIKTSTSSTEECLESCSGSPAIKFKTSVFHQEHDGESIAVGYKLVIKIKDVDEPMTWTSQQRYKIRDTTITTNGSANDKKFTDGEIAGIVIGVLLGVVLIVVIIIAVIFKLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBG1</accession>
    <name>A0ABY7EBG1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33153">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33153:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="1">
        <location>
            <begin position="42"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="84" mass="9494" checksum="C2688D8E2CA6E805" modified="2025-10-08" version="1" fragment="single">MPKGLSSLWKVKVSLMGSIVHGAYGFFDTFQWAHGSSFTISGQNKNRYMLGFLAMLVHLGVFRKIKLSFLMVGHTHEDIDQLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDB8</accession>
    <name>A0ABY7EDB8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FLVC2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_017973</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd17398">
        <property type="entry name" value="MFS_FLVCR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF4">
        <property type="entry name" value="GH15861P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="70"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR08015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="511" mass="55433" checksum="F6C448251B703BAE" modified="2025-10-08" version="1">MGGNVSRKQKRPESSADQLLPPSVPTTPTSPDPLLARDPLAALATKPSLDTMEESIAPKEYKRRWVMLLLFVAYSFSNAVQWIHLNIIGNVIIRYYNESLPEDSFQQETAIDWLSMIYMLVYIPLIFPATWLLDKKGLRISLICGAFLNALGAWVKCACVSPDRFPVLMFAQTICAIAQIFILGIPAHLAATWFGPNQVSTATSIGVFGNQVGCAAGFLIPPLLVPNSDDLDVVGKDLSIMFYIWAGLCTAIFIAICVVFKNKPPRPPSKAQMLADTSGNQENYFGSLKNLFGNKGFLLLALTYGINTGCYYGIGTLLNPIILHYFPGHEQNAGQIGLVLVLAGVVGSVMAGLWLDKTKTFKGTTVGIYLLSMAGMVAFTFTMDVGLIWVVFITAGALGFFMTGYLPVGFEFAAEITYPEPEGTSSGLLNASAQTFGIIMTIGMRTLLNRVSVMSANITVSAALLVGTIITALIKADYRRQEAGKRAIGYLDNVQFDFNTSNKDKTGDGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDK7</accession>
    <name>A0ABY7EDK7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="877" mass="96131" checksum="6C33C5051FAE1B4A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDV4</accession>
    <name>A0ABY7EDV4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_017070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd22791">
        <property type="entry name" value="OTU_VRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047273">
        <property type="entry name" value="VRTN_OTU_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="54"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR07112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="594" mass="66878" checksum="C02F73AA4F0FCBF6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EE39</accession>
    <name>A0ABY7EE39_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="106" mass="12406" checksum="68917BB1E05D4E90" modified="2025-10-08" version="1">MRSLDKRFSLTEAEGRFQKACDQIVLLNHRLGEVQKRCKMAKRSNNKAFRYNLRLNLAVIEGVRNMYYDFAYSKADRVAELRRELFDESVEIVSGSDSEYSSDDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEM0</accession>
    <name>A0ABY7EEM0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">KEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_020975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KEN" evidence="4">
        <location>
            <begin position="416"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR05606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="545" mass="62800" checksum="F16482A401CFE9C1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEM9</accession>
    <name>A0ABY7EEM9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="256" mass="28916" checksum="2A4419DF5C9A012A" modified="2025-10-08" version="1">MSEFVHLWTTSLSHPGGRLLHLQTFYRLCEALHWFSLMAPIVRLYGRVKCEKTGYLGRDGVVIRHDMYNLTSAPIMVLDYVCRTKGRRAEKYAAGSVPASDPNAECSYSGNDVLTEGDELLRRGSPCLVRLEGSTSWTSVAAKPFTNHGRCPVGELENLIEAKVARGYILMVQENLFEAKVTRGFILMMQENLIEAKVTRGYILMVQENLIEAKENPFEAKVTRGYILMVQENLIEAKVTLGYILMAQENLFTEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEZ5</accession>
    <name>A0ABY7EEZ5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_018551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR08593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="149" mass="17073" checksum="4163F377FA0D2708" modified="2025-10-08" version="1">MNFMAKNYVLIPNVIRLMFDNEDCGAREDVMRWADGYVLVYSIVSRKSFNLLQEVQKKVEEFKKGSNVPIVILANKADLEHMRQVTSEEGQTFAISLGCPFIELSASEDVSDVTDAFHALCRDIVEYKRRSRTFFDRVFGAFGREKVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGB1</accession>
    <name>A0ABY7EGB1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CCD58-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="13692" checksum="177D6759C492EE1E" modified="2025-10-08" version="1">MAAPMVDGTKDFCPCDDIIRFTKTLNKLRQSDDRFIYKLNSMLPTQTFKTRVNPKEECAHLYEHSEIHELRQKQAENRDDTIVREKLHTATYMIKQFQKELFYERCGDHYQPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGG4</accession>
    <name>A0ABY7EGG4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="153" mass="18576" checksum="D8132A0F56C1D75D" modified="2025-10-08" version="1">MTTWDIFEEVIMTTWDIFEEVIMTTWDIFEEVIMTTWDIFKEVIMTTWDSFEEVIMTTWDIFEEVIMTTLDIFEEVNMATWDIFEEVIMTTWDIFEEVIMTTWDSFEEVIMTTLDIFEEVIMTTLDIFEEVNMATWDIFEEVIMRPPGISLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGJ1</accession>
    <name>A0ABY7EGJ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UPL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_017736</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="3">
        <location>
            <begin position="242"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR07778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="563" mass="63018" checksum="6538E5CD0F0A4FB0" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGM7</accession>
    <name>A0ABY7EGM7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RWDD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="1">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="ZC3H15/TMA46 family C-terminal" evidence="2">
        <location>
            <begin position="95"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="195" mass="22790" checksum="B9A28829ABB62E53" modified="2025-10-08" version="1">MTDYKEEQQNELEALESIYPDELKASCVLKFTYSATYPDEPPLMEVSEAENIDEEQQAEILSLMQSEEQLTTLIEQSKQRRKDEILQRLREEEELEQFIRCQQHIQSVGTRVTIENFLAWKAKFDAEMAELQKHQRKSDNNKKLSGKELFMLDASMIDSDVQFLQAEGEKVEVDESLFQDLDDLDIGEDDLDLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGV6</accession>
    <name>A0ABY7EGV6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CP39A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_018055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR08097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="420" mass="48784" checksum="6103214B2E03481F" modified="2025-10-08" version="1">MREMIALFNQSDLWREICTFCLILKDNYIKQLTVCVVLCTIFCIYLRRVKLKLNSPPCCRGWIPFLGCALDFGKSPLTFIGQKKDEHGPLFSVYVAGQTLHILTDQTMYQVFFESPCLDFELTVFDAITKAGLINKDKFIERHSKLYHAVKGTLSPLRLDDVTGAICGKFRKQFDQNYLQFIEQFECFDENFELGVQLPSIFIRKWTQARNSLLKRMSEKFFKSTHKDNMIVFWAIARILTDERVKQKLYQELNELRSEKPNNDFDLSFEDLKQLPYLRCCVQEALRLQSEGIVGRKIVKDINLLGYDLQKGDLLVLCPYWAHRNEQFFPDPEAFKPERWEGVSFARMSYRQGFIAFGGGRSQCPGRYFAHSVMQKFVASFLLQFHCTPHTPVPAASMMHLVGVQHPTSDFIVSCSKRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHB7</accession>
    <name>A0ABY7EHB7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CAYP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_019351</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051581">
        <property type="entry name" value="Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524">
        <property type="entry name" value="CALCYPHOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524:SF15">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR09393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="513" mass="57171" checksum="9DEC70B7E169C127" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIH1</accession>
    <name>A0ABY7EIH1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TSP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_018152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF21">
        <property type="entry name" value="SEMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR08194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="128" mass="14197" checksum="95FF878954FB01BC" modified="2025-10-08" version="1" fragment="single">STAAGHSGVPGGNVMSPVETEQGHVSGHVTTLPLHMVVTTVKATKIKQLRESHCRTKQLILKSCVKWFMTAVGWTTWSNWSACSVTCERQRSRSCQNPLASLMNNSCSGDAEETQTFKIVRRHRRDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EIN7</accession>
    <name>A0ABY7EIN7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="521" mass="57332" checksum="04415201AE8B273D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKW9</accession>
    <name>A0ABY7EKW9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">MLP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_019394</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF52">
        <property type="entry name" value="MUCIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0768">Sushi</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Sushi" evidence="14">
        <location>
            <begin position="160"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="11">
        <location>
            <begin position="221"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="13">
        <location>
            <begin position="582"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="15">
        <location>
            <begin position="723"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="1135"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="1256"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR09436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1293" mass="142287" checksum="48DBBC816EF56B11" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMQ8</accession>
    <name>A0ABY7EMQ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="116" mass="12531" checksum="5C8301F8E15E11AD" modified="2025-10-08" version="1">MGSYVYNGTNTCRMGQIRVEWDKCVYNGANKCTSGLYVAKMKSLLFACVSFAFLASVIFAGDIERKCLETKSGDDGCKRNATHWECLCSDESGCNGRNSLVPEGAAYSVAAISSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQ47</accession>
    <name>A0ABY7EQ47_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_026290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR12110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="68" mass="7378" checksum="32AEE406B888809F" modified="2025-10-08" version="1">MSTKSMSCISALYDGTKLGIADTCLLTGGTHGAWTNPHLDNAGLIRYGVIFCSSEVLRWKTVAKVTEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETP0</accession>
    <name>A0ABY7ETP0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA polymerase II nuclear localization protein SLC7A6OS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_027503</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Directs RNA polymerase II nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040218">
        <property type="entry name" value="SLC7A6OS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196:SF2">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="11">
        <location>
            <begin position="216"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR13323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="359" mass="40380" checksum="B32BDC9036728096" modified="2025-10-08" version="1">MLLTKKRKHDTNSTDDTPVTENSNVFKFAGTVSKKSAKQNRFKVISKQRAVNLEQLDNPEENESENTNNNASAESDSAKKEKRTICDLCGKSLDNGRRVDSVATIGVNDSACTQCGLSGNINGQSSATDSLSKSDKESGSQLKPDSGLGSTVNGKGGDKRVRFTEQGKVFNLVDVVADSAQNNVSNQIEGVSSDQITCNSEPMVREMVTERGLNDEEYVYDIYYTNSRDFDFRTLERDLTFEAFNEELMHEGDSDFEEEQFVYGDDEDENDEGNWRNDYPDEDPRYIENGNYNYDDDLNEYVAFESETGNQLADWMSWRCNIDGNELSSDEGDIEPYSEQPRSPDTYCNHVQEEVDTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETV0</accession>
    <name>A0ABY7ETV0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase family domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_026306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd10283">
        <property type="entry name" value="MnuA_DNase1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.320">
        <property type="entry name" value="Photosystem II 12 kDa extrinsic protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004509">
        <property type="entry name" value="Competence_ComEA_HhH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051675">
        <property type="entry name" value="Endo/Exo/Phosphatase_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00426">
        <property type="entry name" value="competence protein ComEA helix-hairpin-helix repeat region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180">
        <property type="entry name" value="ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180:SF32">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12836">
        <property type="entry name" value="HHH_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="3">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="3">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="3">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR12126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="550" mass="60758" checksum="40CBE76CA509C480" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUG3</accession>
    <name>A0ABY7EUG3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein quiver</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_035917</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046329932" description="Protein quiver" evidence="3">
        <location>
            <begin position="24"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR10841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13117" checksum="DF0DC7D3DE2FA25D" modified="2025-10-08" version="1">MDAKKVFCFVFAVVGVLAGVSEAIKCYDCTSLTENCKDDFKKEGITIKDNCSACIKFKGLSVVRRCSPIKVGKNECKEVTLLDITMIVCVCDKDLCNGTPRVTVTVFTLVTDVLAAFKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVV3</accession>
    <name>A0ABY7EVV3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="146" mass="16334" checksum="255CA13D058F30BA" modified="2025-10-08" version="1">MDYVVSCGLQSTFWSYFLLCLLIGFCDLSVAEIKKYTLCNEKVDMEAQGIQQGELELAIHTYSGSDSRVSCDFTVSAGNGRHVMFYFTDLFLGSQNLTERVDRACIEPRDINGNYETFLTGMRPYICSRAQVKIGSKVYATTGNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EW58</accession>
    <name>A0ABY7EW58_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="31571" checksum="7AC2220003ED865A" modified="2025-10-08" version="1" fragment="single">MHEDGTENPNVILRDITEERCKQHPTEKAIFLCKIHDSTICGRCLHSGHRPCGEEVVDLLHEVVNIDCEKVNTMKSLLMEIKDEILLLKNEAEHSKENYKENADKCVQECMGFENKIKQRVDELTSGIRDGITKKHNENLTIHSHITKLCDEKTKWCRDLESKIDSFVDKNMAGHLYLMNRYFEKEVSDARSHLKEFKHKHTFKGFDFKENKVILKCVFEDLEEVCAHQEEITGSDDGNANDVGASTTKINQTRRELTVLLSQIKQDLDQSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0L9</accession>
    <name>A0ABY7F0L9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="251" mass="27910" checksum="8A6FF82AEAC61EA5" modified="2025-10-08" version="1">MNCWSLLQTKCSHGMILALCRIQKKSLTVLCCLDDVDSPEMTPESLVRPKMLGVWKLSKVTVIVNRDLFPKTSVPPEMQPDRPTQACAADQFDSLDSGPSSIICRSTVIVFPLTVRLIDDEVMFVTEDNFHKCGPSVSAMRLWLEYKTTTAKRYYAHTKENVNLLNYDKMNCNKTYLKFSLTFIDVFVFAISTSSIGSTSGAHDGRQTHDTSSLGLIGGLCKPAALSIILLSNYPLANNREKPQIHVALTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1E7</accession>
    <name>A0ABY7F1E7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RCC1L-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053035">
        <property type="entry name" value="Mitochondrial_GEF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337:SF1">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="153"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="261" mass="28399" checksum="96F1323C3D07D5C0" modified="2025-10-08" version="1" fragment="single">VKDVACGYGFTLFAVERNRIQMVLGTGINTDSQLGFHEFPKNTGRVLDYLIEPVPVAIPGIPEGRERNILQLACGRAHSVILTKHGGLIKYIVSHVFFSPRRYSIISVLFIPVFSQGNNAYGQCGRPVVEGEIFKITDIASRADCVLAISESGDVFGWGNSEYNQLSMVTQETQVSVPKYLPIKNCGKITQIASGGSSCMVLNEKGEVYVWGFGVLGKGPKVDVLTRPSLLPPPLFGRNELSPDVRVKQIKSGISHFGAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3E2</accession>
    <name>A0ABY7F3E2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SGPL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_031287</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF9">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR16693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="481" mass="53208" checksum="0BC0DB0FA4030682" modified="2025-10-08" version="1">MVLKSEVSSFVKSTSLAQDVVAAKPRVVLPRTGFTADELRSQMEKLLKRESNTDKDGNVFAYTYTLKDEHYRLQQEAFDMFCEKTGYSGEHDDIVKEFFHAFMHENALNPMIFPALRLMETEVVSMTAAMLNGSSETVGFLTSGGTESNLMAVKTFRDMARAQRTNIRRPNIIAPITVHPTIDKAAHYFDMDVIHTPVGNDFKADVNAIEQAINSDTVMIVASAPQFCHSVIDPIEEIAALAARKGIPLHVDACFGGFMVEKLGYKIPKFDFRIPGVTSISADVHKYGYSVKGASVVMYRNASIRKFQIYAYSEWPGGLYGSPSMAGTRPGGNIAAAWAAMKALGEDGYMRKAKELMLVTDKMKEKGLCLMGEPCMTAFAIGSDEPNLNIQAVADAMETKGWKMERNQLPDSLHCSILPHHISKVDKFLDDLEDATDICRNNKALAKKGTAGVYGMMANIPDKGIVTDFLVEFFSEVYKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4P9</accession>
    <name>A0ABY7F4P9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DZIP3-like HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_031171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22660" checksum="46F2AD751AFE2AEE" modified="2025-10-08" version="1">MASSGPDRESIFGKRNNIDANNFHRLVGLQYECGTTVLRKYLTFYISKIRKTNVNDFLKGLSLKLQTEIKDLTLDAFDITLLTKIILDECKPTGDIKKAVRALRECRNEIAHNPKGEINGKSQFNKASQNILTIAISLGDDVKRQFAERMNELHQSELVRSYSIVDIIKYNEELLEMRLVYSAPDGEHFSDYNGNREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4T6</accession>
    <name>A0ABY7F4T6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="140" mass="15391" checksum="55FFDEF96ECEC52B" modified="2025-10-08" version="1">MEELVDREMMVHCEKEGGECIDVDFGTTDPPSPPETTRPPRPTTTRAPWRLTTTTVPLPQPPAFQWFFNNPFHHLFNPVVPIIDQPLWYDPFIPTKKRTLPPTLAPPLTTAAPSTTTAAPTPAPTTAAPGTTRKPKPGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5Z0</accession>
    <name>A0ABY7F5Z0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ZBED1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_004831</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="26"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="479"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR14726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="629" mass="70468" checksum="AB0878890384D59C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F795</accession>
    <name>A0ABY7F795_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_031628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="163"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR17034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="339" mass="38609" checksum="C513D167DB4FFBBD" modified="2025-10-08" version="1">MAFTAMLCLVAQITRDIIFYAILHDTIEDDAVGPPLEAIAGGVGGGVVAIGIVVALSIFFRRSTRKPVSSQTMQNGNTTFQADIVRNPSHRRKSTCYPATSKRTHCNKQVFTHEETAFENENGLEIDDESNGGLILLPLMIIRITKNLEHPVTSQKYPLMNLNHEAFVAEFEKFSRDLVKPYVESQKKENLSKNRYKGGYKKPQQYIATLGPMSKQLENFNLFWKMIWQQRVEKIVMVTNLVENGSPKCEQYWPNQGATKTYGDKKVESRSEDEYAEFTRRVFTVAMGTEERTLHHLHFTCWPDKSIPDDITAIIEFRQRVLTTPSTLNGPTVVHCRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7U2</accession>
    <name>A0ABY7F7U2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ADPGK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_000098</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007666">
        <property type="entry name" value="ADP_PFK/GK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208">
        <property type="entry name" value="ADP-DEPENDENT GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208:SF1">
        <property type="entry name" value="ADP-DEPENDENT GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04587">
        <property type="entry name" value="ADP_PFK_GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51255">
        <property type="entry name" value="ADPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR18260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="459" mass="50933" checksum="6A9F07F702DB4EE8" modified="2025-10-08" version="1">MLSLNTKSIVILSTIILLCAFIYKKKSDTLQKEKIHQVLHGLLRAERKVGVDRNTRIALGFGGCEDIFVDAQDLLQGLNYTVPSDPEHVTDILSETDFTKIFTYFFKQGAAGERYVENATLFSEIAKVARSVPGARTALGGNAPAMATRLAMEGAEILLAARFTQEALKLMPDTIKAGSRWGNYTASRANRFIIHSDKSNPFLDTLEDLEAVLPAFDPSVLVVGGLQMMDNFPFKQGVRKERIEKLREMLVKTDRSTKTHFELASFSDETLMREIVDNVVYYSDSLGMNEQELPNLVSILTSGKIALVSDSKPRIASVLDQMRVVFNLLKNTEEKDGKRKLTRLHLHTLAYQAILTQKGSDWKNTMAAAAKASLTANRHVCGSNYIDMEKAKLLMDESFSTTARVEEASKIPLEENRPVSCWSEEEFDICLAPVLVCTEVFQTGGGGDNISSAGLLYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7X5</accession>
    <name>A0ABY7F7X5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="18">AIG1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MAR_031721</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">MELC-2E11</strain>
            <tissue evidence="18">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52072"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136312"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:52073"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>12-(9Z-octadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52060"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136302"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:52061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>12-hexadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52056"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83677"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:52057"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>12-octadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:52081"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52076"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136315"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:52077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>13-(9Z-octadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136303"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:52065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52084"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136335"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52085"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52068"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136309"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:52069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>9-(9Z-octadecenoyloxy)-octadecanoate + H2O = 9-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52048"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136282"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:52049"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52052"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83670"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52053"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:52097"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WAR17127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="195" mass="22239" checksum="D6C720123DB9534A" modified="2025-10-08" version="1">MVDNVRLMQTVYFGLSIMNDLKGSHAKPSDGGQKSKLQSFLDVYLAALVYPVGVFVVMTFWGIYAVDRELVYPKKLDELIPQWLNHTMHSTVLPFLLIEKIVVYHEYPTRRRGMSILLAFALLYLCWSCITYAGSITNAGISCITYAAYYANIWVYPVLAVMEVHQRAIFIGILCVFFLTIYMVGESLNKAIWIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F9M4</accession>
    <name>A0ABY7F9M4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_000713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR18875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="80" mass="8528" checksum="958FD53CFFEBAF4F" modified="2025-10-08" version="1">MWVSKMDTNMSWGTNVNSLTKPAGLPPLGEHGQPEVITLLTTYRRRLATRRLLTLDFGSDVALLAGHPGAGGRCPLGSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAF3</accession>
    <name>A0ABY7FAF3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RTJK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_000913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35151">
        <property type="entry name" value="ELONGATION FACTOR 1 BETA CENTRAL ACIDIC REGION EUKARYOTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35151:SF2">
        <property type="entry name" value="ELONGATION FACTOR 1 BETA CENTRAL ACIDIC REGION EUKARYOTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="136"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="861"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR19075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1316" mass="143422" checksum="9ED24DC95190E746" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBP4</accession>
    <name>A0ABY7FBP4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_000052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF216">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="102"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR18214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="337" mass="38269" checksum="457C8C172BF0997B" modified="2025-10-08" version="1" fragment="single">MDQTPVECSETFPDCRKTEVDVKEETDALRDWIIQQPEIPNFIESRVLAAFLNVCKFNQTNTRERLRRYWVTRRDGILQHLNDLDPASPVVLEILRGPHAVYVPLPGRDKEGRRVILARWNELDVSGVSYTFEEWFRAISVVFDVVSFMDETSYRNGITILMDAKGVRLAHLLFFGYTNSCKQVAMMQIALHGTKYEKLFQHVDVTCLPDNYIPASADSDGTGVGSIHDIKERFVHDELLAPRTLTFLRELYSARAGQDEPCPRNSGLKLEEKPAPRDGVLLPGEETPAKPSYVRTFDVIEAKVDVDNVAVSVRQLYLVNDATKVQNADGDLVLIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBQ4</accession>
    <name>A0ABY7FBQ4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ZN879-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_032692</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR18098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="618"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="646"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="954"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="982"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1184"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1357"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1386"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1413"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="370"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="505"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="682"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="854"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="912"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1057"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1101"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1211"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1262"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1295"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="550"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="573"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="711"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="794"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="827"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="916"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1074"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1110"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1121"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1211"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1262"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1295"/>
            <end position="1308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR18098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1446" mass="157873" checksum="061D2465235711C8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGB5</accession>
    <name>A0ABY7FGB5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19576" checksum="618535C2300C49E3" modified="2025-10-08" version="1" fragment="single">MGSTFFGSMLGSRDDTFYWHEPLRFLSRYSLFRGQDLLCDYSKPSCEIISPTANLTRQHYLKMIQETFRQGHLPCLPTLEASCKRAKHRVVKVIHTDLSGLENLYHMLPHLKMVALFRDPRGTIHSRLRTPWYESVIRKANAVEGDIAVMCSFMKLDIKTAQEFLMKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGU5</accession>
    <name>A0ABY7FGU5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TTF2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_014796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF50">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="514"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="877"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="620"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="742"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="768"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR20822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="994" mass="109968" checksum="B05DC3B9C3B719B3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHN1</accession>
    <name>A0ABY7FHN1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C1QT3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_015667</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF89">
        <property type="entry name" value="CEREBELLIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046408240" evidence="5">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="6">
        <location>
            <begin position="122"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR21693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="246" mass="27380" checksum="2C12EB4FD9F2EC54" modified="2025-10-08" version="1">MKTLLPSLFLFGIFQVSNGNVMETRLELLEKQMKEVLEREAHTKRENEELQATVASQQSIIVELQATVNEQSDRIEALESERVDSEQGGAFQDSTQMHDTPKSDVINGGKYARSGIISRRQPPEMMVAFSAVKVAIQSSIGLNQNIIFENVILNQGNGFHSQHGVFIAPQTACYTTATLLSHNAAIIHDGNIVAKMHGYQWEQFSQTVIIAVNAGDEIYIRNIAHDHETISGDSFSTFSGFLLWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHX0</accession>
    <name>A0ABY7FHX0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="6">PARP</shortName>
            <ecNumber evidence="6">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_015749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="6"/>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd01439">
        <property type="entry name" value="TCCD_inducible_PARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF67">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WWE" evidence="7">
        <location>
            <begin position="52"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="8">
        <location>
            <begin position="126"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR21775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="324" mass="36992" checksum="CB6F671FECE3F9E2" modified="2025-10-08" version="1">MNDKQLKAIKQKADENNVEYTLSGGTIKIVGLIQNMINVTDDIYSSLRDAAKIEQDHNAAMILKDIIQWYWIEQTEMEDELKPYEMMLNYQIEQAFKAQEDKFTYTDNGEMVIVDFKNCSEYCQSKPDEKDIILRKDLIKAPSRCNLSLPKAGREDNWRLQIISWLLIEKVQNKSVWLQYEAKKKQLEGQNPAGTKKEQFLWHGTSEDIVDSVNAHGFNKGKNCGKNATAFGDGVYFAVNAKFSCQDAYSRPNTQGLKRVYYCAVLTGEFILGKSGMRVQPPKPNAGKNALYDSVVNNVAGPDVYIIFNETQAYPLYIITFKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHZ6</accession>
    <name>A0ABY7FHZ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="160" mass="18352" checksum="DFE86C2C16362C38" modified="2025-10-08" version="1" fragment="single">MSRYSNDSSGVAAAMGSGSYKYPAERDQGGHRLEAQKQDQVSLQRSKEASKQMLYGVFCNVIAILEEFEQRERPDWCRPLESSRLKISDQSRKSNEDIKHILETQLLLFEKQSNSSPAEVRNEVVDELKKRVLQWAGFRADEKCDGQTTDIYVAQLYEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FI76</accession>
    <name>A0ABY7FI76_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PAR14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_015246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF67">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Macro" evidence="6">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR21272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="123" mass="13654" checksum="CE8E32E349270047" modified="2025-10-08" version="1" fragment="single">ADAIVNSTSDDLNLENGYVSAKINRAAGKKLQKAVHKEANKINFWDYINMRAMVRMLLNEANKMSCHSIALPALGTGNLGYHPKDAANAIFLAVCDFVELNGDTSHLQEIKIVIYKKDENTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIU5</accession>
    <name>A0ABY7FIU5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_016079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR22105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="321" mass="36753" checksum="5146B2AA06E144D4" modified="2025-10-08" version="1">MPVNDNASSSIKRRTKIAVLIAAVADLATPSLSCEYIVESRRVSQRDLPPVRPLRHLNGTCEIPGRLRDRWTLLTPDRERLRIRSHSMTARYPGQTNLTRIRYRCLESRGHTFLLGTETSIGRQGSGVLCLGFAAIFGNSVVGEYSIVRLNAVGYESHLLGPQLLPRTTVKWPTLNDTCVQAADQKDYYAEIVRAERRCVFPDELHRTWNFTHHKARHVTFAEKTFTFTFMDGSVHKFDCNVKEGDIYVLREFEFTDGQDGVLCYNITRLLEDPHYNFEMSRLNSGDHMEGMVRLLPVGRPVELSEDCDWLESPARPEFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJZ9</accession>
    <name>A0ABY7FJZ9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">TWK18-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_016508</name>
        <name evidence="17" type="ORF">MAR_016509</name>
        <name evidence="18" type="ORF">MAR_016515</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF335">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="196"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="363"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="523"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="604"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR22534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAR22535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WAR22541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="635" mass="71124" checksum="29BD7B8AE71C18F6" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLG5</accession>
    <name>A0ABY7FLG5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyl-D-glucosamine kinase</fullName>
            <ecNumber evidence="2">2.7.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GlcNAc kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_015683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type N-acetylglucosamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.59" evidence="2"/>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039758">
        <property type="entry name" value="NAGK-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12862">
        <property type="entry name" value="BADF TYPE ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12862:SF0">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase BadF/BadG/BcrA/BcrD type" evidence="5">
        <location>
            <begin position="75"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR21709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="237" mass="26092" checksum="480A5E518561AD88" modified="2025-10-08" version="1">MSKFHYYGGLEGGATQSKFVLYRSDGQILAWSKGECTNQWGLSMSGADEEESQKQLIAQIKSQYGGDCEEVYIASGIVLIAGTGSNCQLINPDNTSKRCGGWGHLLGDEGSAYWITQLALKTLFDHDDNLNICPNSVEKVRDIMKDYFKISDKVGMLDHMYSKFDKSNVAGMCKHLAKGFLEVLTAERPGRRIREVTLQRLKQAASVGAASLGARAVGFKLPLDYSANAEIFFHGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FM61</accession>
    <name>A0ABY7FM61_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SRAC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_016111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR22137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="161" mass="18604" checksum="C0A7DBC83294BDB3" modified="2025-10-08" version="1" fragment="single">SGPWCFEGTALEYIRSVSDESEGQVELFFLEALARFSQVREQHVQMLEAGILPLLQRVLLELNGWAGVLHKWLFSREPSLFFYSARALANLDGDIDTDLRIPGVFEDGVQKSPRVEVDIVFIHGLLGGPFKTWRQEDRRDTEPNFVMTEEFKQSHTFFWPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNM2</accession>
    <name>A0ABY7FNM2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GHSR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_037492</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="51"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR23823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="362" mass="41796" checksum="083E915D618B1FD8" modified="2025-10-08" version="1">MENNTALNYSMLGNNSGDLHTDFQNAEEPEKWGFWLKTVLTPIIVFAGIIGNILSLIVMKSKALRHKSYSQYLSALAVFDTLTLIIRQIRSVDEYSRDNSSSGVIFHNFDDIGCKIFNFTEHICYLMSSWLIVLMALERLIAVCMPFKKFLIRRRSGATVVIIVLFISMSLSQAFRLVMVEQLESRNCGASDSFIELYSNLHIYFYHMTLTFILPVTFVLVCNGLILYKIFKIRNEINSRVEQKNRHHRVMRKTHRTTCMLLTVSFTYLGTLLPLLTLSLALDIIVKARGREAYIFYVSVTPYLDIAIVVSLINYAANFFIYILSGKNFRYELKKCFYSQTTSIRSLTVRSSKETKEEMIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQP2</accession>
    <name>A0ABY7FQP2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_038207</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="69"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="181"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="331"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR24538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="399" mass="46258" checksum="198199877C110B95" modified="2025-10-08" version="1">MKCIQYWPEADSVNFDDYKVTTQGEENYSDFIIRTLIVEKTGEGKRKLFHFHFTAWPDKSVPKYASSLVHFRHKVETTPVKENGPVIVHCSAGVGRTGTFIALNILTEQASTMGYVDPVGCVNTLRRQRVDMVQTPDQYIFLHMALLETLMLSTSALSASRFLKYYEELMAFDNHLRKRKIDIEFSRMEKMSPVADECQYVSAKEVRNRKKNRYSNILPVADHMPYLTPSGKRSEPDYINAVFLPNYKKKGAFIVTQTPLKATKTDFWRLVVEHDVHTIIMMNNMSEMKEDEIYWPVHNESETYENMTITKTSEDCEGGLRKIMFDFNRNGADRSGLFCVASAVLEGMKVEQDVAITQVIKEMRNYREQIIPSVEQFQFVHEVVKEYILQNKTYSNFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRT5</accession>
    <name>A0ABY7FRT5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR23859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="81" mass="8923" checksum="35504C6748F62063" modified="2025-10-08" version="1" fragment="single">IVYVAEFGNKRLLGYHRSKSNNLNPAWVIRVEMTSDGRVAEIQEVFADDGSRLFGSTGATNVSGKLVICTVTRQAMVCDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTX2</accession>
    <name>A0ABY7FTX2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PLPL8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_011372</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="482"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR25668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="723" mass="81801" checksum="F35A9247EA201AFF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUE2</accession>
    <name>A0ABY7FUE2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IPP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_038127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46344:SF27">
        <property type="entry name" value="KELCH REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46344">
        <property type="entry name" value="OS02G0202900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR24458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="302" mass="33736" checksum="F995FE54D1F8CC9A" modified="2025-10-08" version="1" fragment="single">MSPIRFPIISENQMEKYINSVPDSDLSIKIALQKIVNDFRTDKKLFGVFEKKAKNVNIKPYHLVPRQCSRKNIYICGGFTRPKGGRWSDALTLNTVERYDTFFKIWHECPSFQFNRSALGAGVINGQVCVVGGENDMLILDSIEMYDPITYEWTCIPGMTSPRSLRCWMGCTADNGLMYIVGGSNDLGDELTSAESFNPVTKEWTSLPDLNTRRSYPGVAFLNDCLYAVGGWNEGEGALNSVEKLDLKKGCWVDVAPMCQGRAGPTVVVVNNMLYVMGGRSYEDEYTAPSSLDTMEGYDPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUJ9</accession>
    <name>A0ABY7FUJ9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Copper transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_038213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF8">
        <property type="entry name" value="PROTEIN SLC31A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR24544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21321" checksum="267A35573ADE3D6A" modified="2025-10-08" version="1">MGEISKGNLTMSNLNTEGYNKMDPNIQKFFSTENHGDFILKGLQLNFPAGVVLSMLFVLVLVMLHEGFTYWIQHKLEIIRSLKTFRSKNDQQAAESRFHLIATMNKLLTSALFYLMVLCLVSRNIWILVSAILGKGVGYLLLRPFVSAYGHVGFEKSIERRTYIEMGHVNGTVSGNNEELICPLIEASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUZ2</accession>
    <name>A0ABY7FUZ2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_011762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="134"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR26058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="431" mass="49314" checksum="3EBA34555FFD8D23" modified="2025-10-08" version="1">MAFNFDSSLHKASDLIHEFTCSPCEEDGLNFEAQNFCLDCSKYYCSRCESKHGGLFKRHKVLDRKDVKKWAAVSGTVVGDVERCEHHPGKKVELFCGDHQKLCCHICVSVVHRQCSVIQHIPDVARGIYDKPEYKRLEKQIADIQSQIKKLQESREKNQQCIRDSRAQILLEIRALRRKFDQALDQLEQNTIKELDVMVATFEEQKKKIIEQSAQLTKDIKSLADSMAKTKTNNSLAYVGYSRCQKLITETKAFLEDNTNKQEVELAFVLNTGLNDLITSIISLKWIGVITNSSHVFKIENVKQLNAALRIDKKISNISGICELLSGELVLVDNNNCRLKLLNQSYQIVDHCDVPTNPLDVCHIAGNELVVAVNSDKKNRHEVRFFNVMNSKLQQTRELSFNHTIRQIAHYSGRMYITSDTALYSYDKARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZC5</accession>
    <name>A0ABY7FZC5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_012003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF56">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="1872"/>
            <end position="1883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR26299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2990" mass="325563" checksum="E6B027FAA87C60BB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZW0</accession>
    <name>A0ABY7FZW0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dual serine/threonine and tyrosine protein kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Dusty protein kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Receptor-interacting serine/threonine-protein kinase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MAR_012398</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">MELC-2E11</strain>
            <tissue evidence="19">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051302">
        <property type="entry name" value="Dual_SerThr-Tyr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46392">
        <property type="entry name" value="DUAL SERINE/THREONINE AND TYROSINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46392:SF1">
        <property type="entry name" value="DUAL SERINE_THREONINE AND TYROSINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="101"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WAR26694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="336" mass="38246" checksum="0F902D721C4C9E82" modified="2025-10-08" version="1">MPWSQSPRIDDDWKKKVAAEMLASLSATRLAKSISSQIKDRLNKSHDAFLTALKQLEMKHSGRLTKIKEERLKLRKVHAPRVAKVALESTSLKDVILYGMPQMGREIGRGQYGVVYSCDSWASYTPCAIKSVVPPDEKHWNDLALEFFYTKNIPDHDRVVMLRGSVIDYSYGSGTPAVLFIMDRLQRDLYSAIKQNLDWVSRLQVSIDVVEGIRFLHGQGLVHRDIKLKNVLLDKDNRGKITDLGFCKPEAMMSGSIVGTPIHMAPELFSGRYDSSVDVYAFGILFWYICAGSVRLPQNFEQCANKEQLWNYVKNGLRPEHLPVFDDECWDLMSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZY4</accession>
    <name>A0ABY7FZY4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NRF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_012311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019525">
        <property type="entry name" value="Nrf1_NLS/DNA-bd_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10491">
        <property type="entry name" value="Nrf1_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear respiratory factor 1 NLS/DNA-binding dimerisation" evidence="2">
        <location>
            <begin position="189"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR26607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="616" mass="69186" checksum="DA96334A8D639306" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G0H4</accession>
    <name>A0ABY7G0H4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_013424</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">Golgi stack membrane</location>
            <topology evidence="12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="115"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="228"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR27720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="428" mass="49888" checksum="960825F889281509" modified="2025-10-08" version="1">MAVRCSKVKRQFILLIGLFLVLTFILQMVPSYFEVQTNMLTALQFAKFESRLLNNKSFTVANRLNDPVALWKVHPSDDRILLQAKFNPKIDLSLSPKRILLEQGLAGWNVNDGKQAFVDHDCPVKHCELHGHPNGEEFDARIFKEIELNSHFLGGAQAEVRRHSDQVWIMFALESPEASPSYVGLNDVINWTATYRYDSTMMTPYDKFQIYDNFTQISDYKSDKNYAQGKTKLAAIFVSNCYASNARLEYVKELQQYMDLDFYGSCGNLRCDKGEGNNCFQNLQKEYKFYLSFENANCRDYITEKFFLNALRHDVVPVVMGAHPDDYRRAAPPGSFIHVEDFPNAQALAGHLKRLNEQDDEYNDYFRWKRTGQFVDTKFWCRICSLLWDTDLPHQSIHDLEQWWRGENICIGKRRWDEISNSSKLHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G129</accession>
    <name>A0ABY7G129_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">alanine transaminase</fullName>
            <ecNumber evidence="8">2.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_010765</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-alanine + 2-oxoglutarate = pyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:19453"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="73"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR25061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="454" mass="50549" checksum="B580D73935177DE3" modified="2025-10-08" version="1">MGDEKRVLTMKTINPRAVEMEYAVRGPIVTRSVELLKELAAGAQKPFSKVVDLLNSDSFPDDTKQRARRILQGCKGQSTGSYSASPGIDVIRQDIADYITKRDGHPSRPEDIILSTGASDAIKTVLNLLMTGDSGNNRAGIMIPVPQYPLYSATLTEFNACPIPYYLNEENKWSLDVSELKRAIDEAKGKCKPRAICVINPGNPTGQVLSRKNIEDIIKFAYEEKLMVLSDEVYQHNVYAAGSEFFSFKKVMTEMGAPYCNMELASFMSASKGYMGECGFRGGYAEIVNLQADVKAILLKSISAKLCPPILGQVVIDTIVNPPQPGEPSYEKFKKEKQEVLSLLKKKAVLVTELFNSIEGITCNEVMGAMYAFPRLHLPEKAVEAAKQKNQSPDFFYCFQLLEETGLCVVPGSGFGEKPGTYHFRITILPPLEEMRAVLEQFKLFHMKFLQKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2I4</accession>
    <name>A0ABY7G2I4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="305" mass="34455" checksum="F301B51D24FD1752" modified="2025-10-08" version="1">MGTKYNMRTFFLLNKITLRGAKCGQQRLSKWINSNPSVGLLAVPPLHSSVEVQVLIIPVNHQEMMYCLNFKSVAQWLQGIAEKKDEVDGLVHLQFFYESIDTRATAESHIVISSLYGVLQIHDYCLSRSLLLQVVDRLLSLGGDLLQFYDLSSRIFTSVFSNSENLSLSSSHFLRCAKTEEYCVSDVPSQGYTQTEVYYVSDVPSQRIALRDLSSQRCALSEYFNRFLKPVAANDIFEKFQHPVIMLSLTFRLHHGNLLNLTLSNIIHPTYDLKFSLTIFEIIRRGPLISYEATPSGAAGTSISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3G2</accession>
    <name>A0ABY7G3G2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_002561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR28993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="422"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR28993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="625" mass="72303" checksum="4D394C84ED956D0B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G431</accession>
    <name>A0ABY7G431_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="131" mass="15572" checksum="C95EA26CDF2B582F" modified="2025-10-08" version="1">MMYLQNIINWCIYSLLVPWKCFVELLKMICMPLHAFIYNYNADEREWNLLKNMISTKVAIEEATCILVLIKYDHTRIENCVSPCIEKMMADEKMRDKTKILIIYNEKHHGYFDDERIAGSYKAKDARKPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4E1</accession>
    <name>A0ABY7G4E1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="347" mass="39553" checksum="3626D9B9AA00CBE8" modified="2025-10-08" version="1">MNSLYNEVVEVNTDNGVIAVKLGVICGVFDLPAKAGILNMTYFNGTEACITCEEPGVVVKQGKGSSRCYPYRNVAEQYPLRNSPEVLENMRNATDKKRIKGFKGISGLAFLQSFDLVKGVVPDYMHCILLGITKTLLLKWFSPTQSGKNYFIGKHIKTISKRLQNIQPPTSIERLPRDLEKNMLITQKPQNFKLGCCFMVYHVYREYYQKFFWYILHIYLKLQYIARALDRAAMLLDKFYYSFADLYGQGSCGLNVHNACMHLVWYVKLWGPLWAWSCFLFEDNNAMLLQAVHGTGHVMRQVMLKGVRSAQSTLWKKTAEAANCDISGKVKHLRDNELEAEVLALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G519</accession>
    <name>A0ABY7G519_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="92" mass="10478" checksum="F44FB06683C92B5A" modified="2025-10-08" version="1">MGLCRSVCGNSCADGAMMSVRVAMHWDAHRTDIRRCYVMEGLGWSNLVKTVQSSDSMDEQVLGLFQADLIVQYHAYIRAQAEVLQERRRQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5W9</accession>
    <name>A0ABY7G5W9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COMDA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_014165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037361">
        <property type="entry name" value="COMMD10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12333">
        <property type="entry name" value="COMM DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12333:SF0">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="78"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="147" mass="17269" checksum="0D7FC875E1EFAC48" modified="2025-10-08" version="1">MATLMFSSTPSIRKAVSIINNLDGSKFPLLLSRILQKLHMKDERTFSEEEEERLQSTLSLEVTDLELLLQTLEFFLQQLDTINWRLNLQMAQSTKTKQKIPNAMLELGVSREERDSNQKIRMEFTHEELYQFYNQLETIQKQLDGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G976</accession>
    <name>A0ABY7G976_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR29753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="127" mass="14778" checksum="326C6F7A5C48282C" modified="2025-10-08" version="1" fragment="single">VRILIIIRRSSRIRECAAVSERPLLYGNNNQFVQFICDSDDHTSCNIDGHNRFHGRRIIATVTTNRDHKRVVPLDVFSRQDLIKLGKISIIFLDATLEWGCYRHDENVFPLKCDFSWAPNRLLGVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9I5</accession>
    <name>A0ABY7G9I5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LIAT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_003319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046447797" evidence="2">
        <location>
            <begin position="20"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR29751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="448" mass="49882" checksum="C417F2CC3ACA7861" modified="2025-10-08" version="1" fragment="single">MSRIFTFWMLAIFVQVSQAATLKFEKESLQITTDTQGPSFICKKGECKLCGNSSKTDTGPGTRSICSRKNPIPNVEEICIIPKDVDIAKLHSCLDVSVKAHVVQYNFSEGHPVQYGPNKANTQRGTQFNKHSTRHTQFNKHSTRHTQFNKHSTRHTQFNKHSTRHTQFNIHSTRHIQFNWHSTRHTQFNKHSTRHTQFNSISTQRGTHSSIYTQRGTHSSISTQRGTHSSISTQRGTHSLISTQRGTHSSISTQRGTHSSIYTQRGTHSSISTQRGTHSSISTQRGTHSSIGTQRGTHSSISTQRGTHSSISTQRGTHKSIGTQRGTHSSIYTQRGTHSLIGTQRGTHSSIYTQRGTHSSISTQRGTHSSIYTQRGTHSSISTQRGTHSSIYTQRGTHSLIGTQRGTHSSIYTQRGTHSSISTQRGTHSSIDTQRGTHSSIGTQRETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBQ3</accession>
    <name>A0ABY7GBQ3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897:SF2">
        <property type="entry name" value="OS03G0226600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897">
        <property type="entry name" value="OS10G0105400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2133" mass="237360" checksum="C6674C6C98BA7B08" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GD54</accession>
    <name>A0ABY7GD54_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AT131-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_034026</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="884"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="964"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1003"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="14">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="13">
        <location>
            <begin position="238"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="726"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR31484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1077" mass="121213" checksum="77F039ADD38BAE8C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GEP4</accession>
    <name>A0ABY7GEP4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35378:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35378">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="217" mass="24899" checksum="A5809B0D0D0E1714" modified="2025-10-08" version="1" fragment="single">MIRNLKPSEIFYSQDSINNVFDRRSQHWNIRIGETLDDICDGRCSVLSIPQIAVKSEGEKWVTADNRRLWVFKQLERLGKIETINVYIIEYIPPAKMTSNNGGVSIRVRGAPGGRWYLEPDKLSKQKEQKTYLLNAHSGSVTTNLRNTNRRPTTACSEPNKNNIDSLLEKSSFMYKPSSANQYVQDVLPKQRHLAIIREDEGHNKRENKPSPTARQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D712</accession>
    <name>A0ABY7D712_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NOM1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_005937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="619"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="824"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="856"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="922"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="279"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="832"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="856"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="936"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ93466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1045" mass="118871" checksum="F18808DF7E0D78A6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D8R0</accession>
    <name>A0ABY7D8R0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="84" mass="9754" checksum="527E6F48033C25A0" modified="2025-10-08" version="1" fragment="single">TLFINDAIHGIDDLLYQANHTNHTIDDQKKIFTLQDHGHKRYVRNPHCWAYPLDLTCISPWNSNQGNRKAGTLITPRHAVWAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAM2</accession>
    <name>A0ABY7DAM2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15363">
        <property type="entry name" value="POU DOMAIN CLASS 2-ASSOCIATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15363:SF3">
        <property type="entry name" value="POU DOMAIN CLASS 2-ASSOCIATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="543" mass="61820" checksum="951D034CF19AD24F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBP9</accession>
    <name>A0ABY7DBP9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Novel STAND NTPase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049050">
        <property type="entry name" value="nSTAND3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20720">
        <property type="entry name" value="nSTAND3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Novel STAND NTPase 3" evidence="1">
        <location>
            <begin position="47"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="443" mass="50425" checksum="562B03DA3B684000" modified="2025-10-08" version="1">MNSVVYTTAIDMHAGKPSKRMKMFSPHLDRLKRTFTKTTSKDLKEDFIPPEEVETIRQKIEENHLAIVVGYGESAYLSTVLYAIKQSEYEPKLCVLLTDPSDWNHVDPDDVQLVVFKDPFGISECDQNKGTTMFNKLDDKQNSCDDSSLDVIIASKGEILNAAMRDLGKISWQMTERERKEIRLYIQEIRFPELVNRVPKRRYHASKIRQHGRSCGIVDVDVQNIIQAELGRPSSVSIQTDPYLRRMADMELQLDKDGEGIITAMTFVEDRLLVVLDRKCRGIVYSDDKLVVSYKGDNSKNVQILDMEGNVQHVFEKDVNGENLFSWPEHVAVSPDHSTIYVSDINNNTVSALTRDGHLLGVVLNNDNLSEPDFTCIRTDPYLRRMADMELQLDKDGEGIITAMTFVEDRLLVVLDRSNDCLCSFDLSTSTQVSKYDMQPAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCW7</accession>
    <name>A0ABY7DCW7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MMAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019362">
        <property type="entry name" value="MMADHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13192:SF3">
        <property type="entry name" value="COBALAMIN TRAFFICKING PROTEIN CBLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13192">
        <property type="entry name" value="MY011 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10229">
        <property type="entry name" value="MMADHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="286" mass="32507" checksum="43F848F6022BAD7A" modified="2025-10-08" version="1">MASRILYHRATGTSRMYLPNLNAAVQHFRAFSWHRDGESTDMYYKVIGDNDTDSFTVWPDKKLGPFGPKDRRFPFPGNVGLTLKDQEPLKFQPVSGSINPEAIFDHIPAERHSKVLQHANEEMEALEELMHDEEGKTLPSPDDLLECVAHDCPTIMRKDFADLFPNMNIMMGHFTIITISQKTKSDMSGWSEEVEDERETLLQSFVQGATDICEALQSAGYWADFVDPSCGKPTDERYRKLGFEIDDLGCCKVIRHHVWGTHSYIGCLFTNAPASHPILQLMKKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DD83</accession>
    <name>A0ABY7DD83_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_028284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ95594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="76" mass="8388" checksum="3642B3620E3193F5" modified="2025-10-08" version="1">MEVKDTVYCVFMELNVYGDTATNSCDVIICDFVYVITPECSQQFPDAETGDKVTKNLIVITIQFVLKVSAGLDLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DD98</accession>
    <name>A0ABY7DD98_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CRUM2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_027973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46967">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN,N-TERMINAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46967:SF1">
        <property type="entry name" value="KERATIN-ASSOCIATED PROTEIN 16-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="6">
        <location>
            <begin position="102"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="199"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ95283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="820" mass="89675" checksum="49A6588F6F25D395" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DE58</accession>
    <name>A0ABY7DE58_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TMM26-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_028622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168">
        <property type="entry name" value="TMEM26 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ95932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="385" mass="43206" checksum="632F8373A386EA99" modified="2025-10-08" version="1">MSIEKDGIPQDLLDPSEEAEIHYYDAEGSLDSSTAKKRKKKKTKRHRKDAILELVNEVENIRTFTVGPGKSIVGELPDINIKNNDTRKKTDTKLEQASGLESIGIEAPGIPTVRTGLPDLTQENNDISKRIAESHPIVKNEREQQTKTKYIETDGGQSLDVERGDGKDRNQDKEGCLSYKKEQRLRAYSTVSTTAKYNTTTTSKPGVLDSIANTILSVEDSTWIVVIQELMIYVLLCVVWLLDNVPHDLLSQQLIAFLASASDIMELYALFDESAVQKDFTVTCVVLGVWTVSFIQFVPVLHQRSSTNKVQDSSMMTDIRDSYEHGPWEIAECIVAIIFQDGPFLSVRLFVVIDLQLVTYSLVFFLIKNLLSLVLLVYRLIGLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIN8</accession>
    <name>A0ABY7DIN8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UPAR/Ly6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="16161" checksum="35C3BA08DA3940FE" modified="2025-10-08" version="1" fragment="single">MSQQDEYSLDRILSGLRCWKCIAHDCDLDPEDNYKATKVDCKGGNQQCMKVQFRMFDNVTHYDSVIRTCTDRPCHVTIMDDLFKCVATPKEYMIGGCTLRTCCSDRDYCNGATTTGKKLWPLNGALMFISISSYFTPIWYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIU6</accession>
    <name>A0ABY7DIU6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ALR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_029571</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30511">
        <property type="entry name" value="ALANINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30511:SF0">
        <property type="entry name" value="ALANINE RACEMASE, CATABOLIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase C-terminal" evidence="4">
        <location>
            <begin position="268"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ96881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="392" mass="43041" checksum="5EB0CC15684F19E4" modified="2025-10-08" version="1">MDTLPDFNYEDAFKLVERPTLVKVDLDRVLQNVNVVREHLSSGTEIIAVVKCNAYGHGFLHVARFLEQYAKVTCFAVATVTEGKELRNITGYEIPTLIQHRLITCISDIVTLEIWNQQRENNVVANGALDSNDVSARLANLPAPSESPPVIIQVDTGMAVSGCHVDQLAGIMEFCKGNCIRVHSLMTHFVDSWEDLDLTNRQLQSFLRVTKPYRDIGVRVHAANTCAVFRGVGTDLDYVRVGVAIYGLPIDSSIASVDESKTAGLQPALSLHCRAVRVLQLDRDQAVGYNRGYMSGERRTCGSATAGLRGRVLQTECKIVGRVSMDAVLVKVPESADDARLFCVLSDDYDPRTSAAALAALVGTSTSEVCVRLNTRLPRVYISRGKIQAFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJB0</accession>
    <name>A0ABY7DJB0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MAR_029736</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF2">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="369"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAQ97046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="689" mass="76635" checksum="744F59191D62127B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKI1</accession>
    <name>A0ABY7DKI1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZN862-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF5">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="333"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="383" mass="43641" checksum="ECCDC916034D170F" modified="2025-10-08" version="1">MTGVHEGLTTLLKRRNPHLLSIHCIKYRLALASRQAADKVQYLVKYQAKINTIFKYYNYSPKHQSWLKKIQEVYEMAERKFKQTFHTRWLSFEGAVDAVIINYDALLTCLEMEVAEDSDPVAVGLLNFVSNYKLLATLYMLRDVLSKLCTLSLVFQMTDVNLTQQTFTLEATLRSLQEMTTTPGPYLKDFLASLPDGYQNGFDLGDDGNKNFIKCSNKEIDASEKIRSTYINHVIENLEARVTDTGIISNFAVLNPENLPQNATDLATYGDQQIHDLGKHYGPSNTNQQSPMTVMSEKHLKCEWSLFKHHMDKNHRTMTFSNMAETVLTSKTLGASYPNLCKIMKFAITLPLSTADCKRGFSKYNLIKTKSRNRLTPDSVNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLT2</accession>
    <name>A0ABY7DLT2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35558:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35558">
        <property type="entry name" value="SGNH_HYDRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="275" mass="31104" checksum="BD179929B618A7E1" modified="2025-10-08" version="1" fragment="single">ELELPHFSPWDLQHLRENNIELVWNKFIGEAASHYFTRTSEDNSTYSKIEQSLYAKYPCIKQEAGTFPWEMKRSSRTRHPAKKKAWSGQPWTLASHHTLPNPETEAVSIQEEHDHLTPLTTRSQAPPTQSQAQVTQTTPAMPELVQMPPNGVQPQPSASNIISSDDDSDEDPMDGAVEAYLNSLLPQGNLQPISTPIISQIKPSIANKIWRNIYIDFTLLLPSAQNSNKFAIQMDKNAQLCIIPTHQAKKIPSIDQWTTAFFRFAAVYLIRRTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DM73</accession>
    <name>A0ABY7DM73_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="347" mass="37563" checksum="9FBE94945490744E" modified="2025-10-08" version="1">MYCDKVVNGSLPTAFSAAISCPPLNSYRPLEAHGSYHQQAGNTSLFLHTGGKKGSPGRGGTPSALNSSRPLGKSFSRMVIVDAELVGSILAPLVLVLPPTPSSVLVLKHTFDLSPASNTICPVYSTKSSAAMTACEPIIWYTAHVTITLPSSPRCLATVHMTLADSVIVRMAELSTSDTVAPPFPWSSLMVNTSLLSSSVSCTAATSILPSLWPSIYVAYPDIEVDGARFMGHDHMMPQRVFDVPHKHLQFNVNVLPTRVTAEGDTMCPGSRPSESWYDHEGRGNGSQKQEVIHRTKINLIPRGQGPADLDSSKLTHCPSHWYRGNLINSTLALICGREFEMKLFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMB9</accession>
    <name>A0ABY7DMB9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondria-eating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_023185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031981">
        <property type="entry name" value="MIEAP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16026">
        <property type="entry name" value="MIEAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondria-eating protein C-terminal" evidence="2">
        <location>
            <begin position="137"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ98812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="248" mass="28257" checksum="CF308A0117BA2C85" modified="2025-10-08" version="1">MGTSLSAQRNGSMFYTSEQTQEELLSELEEKFIEWQEKIKAFKGKIKSSESIRKYLLGEIKTASEYLRTKNTFQFCEGKAELILKKTGEAGSSTISEFMLLQSRWQPKRTSFVDSQTSTDDTLKKVDPIHVDKQMKQLRKEVADSIVPVVQKAYMDASWQDEYLSALKPFINKCLFIGWMMVVQTPPMNFKYASKGDHFDTNIFKQFTKSGKLIDFVVWPALVLHKDGPVVGKGIAQPEIKTANQTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DN19</accession>
    <name>A0ABY7DN19_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHST1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_022911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="2">
        <location>
            <begin position="242"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ98538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="424" mass="48748" checksum="B9BADF91283E900E" modified="2025-10-08" version="1">MAKWSTRLVYQHWTVRCGSLIALVALTACVLNVVMYTSEFAAQRFAAIIDGNRALNDIPANSNAGNVQVIVSAYMNSGSTFTGRVLGFRKDTFYFYEPLWHLTLWGFYRNNDTLCSTREQSCKKISLSKVNSNSPIPGRTVDFKVLHDTDITSNSKPLEVPLHILDHVINCRLLKVKNLIQPGVTDAIKFSGQSWNDYRYCLQRRGSLKHCLEQLEINNCETAQYVVTKVLRMSVGNYRPLLLHNPRLKVVHLFRDPRAIINSRIKTYGYPLDSSGRVKSVEVKRNAEALCSKMISDFEEGMKLQNDFPGRFKFIHYEDITSRDESLIQLHTYLGMRLTLKNLRGIRTDYTKAGASMNYKARDIRKKNNAFWWKDIIKWQTVTIVNAVCANLFDKLGYIRISTEQELRSFNETEVLQNLAFRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DN96</accession>
    <name>A0ABY7DN96_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">GLRA3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_022533</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045014382" evidence="11">
        <location>
            <begin position="25"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="54"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="252"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="336"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAQ98160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="410" mass="46367" checksum="B93E0DF6D67AD194" modified="2025-10-08" version="1">MIPGFTSSLLLVVSEIVFSAFLNAESLSRQATLNSLLGLKEDGTSGNHDANRLKYDSSIAPDFELDVPTEVRVRILIQNIYSVTETSMKWEDKRLKYGNTSELPWLELDNKIMDSVWVPDTFFPNEKKARVHDVTVPNKMMHLYKNGTVLYSIRLSLTLSCSMQLHKYPMDVQICPIVLASYAYTTENVIYRWEGPHPVHLNHAEMPQFGAEVVDNAFTESCKESYGENQFACIQGFIQLNRKVGYYIVQVFVPSILIVVLSWVSFWVDHDAVPARISLGVLTVLTMTTQSSGALQSLPQAIDVWMFTCLIFVFVALIEYSYVNVVARGAQKGHSRKQDRPIELQPLTKERPESNKDNMKQGGPAGKSVGNIAARRVDKISRFLFPVAFVVFNIVFWTYYSFVPHPTNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNN6</accession>
    <name>A0ABY7DNN6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_022683</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="1"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAQ98310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="161" mass="17268" checksum="D9A5DC2616F2157C" modified="2025-10-08" version="1" fragment="single">MVKAFIPPLLSSAHKGECGRIGVVGGCQEYTGAPYFAAISALKLGADLSHVFCTKEAAPVIKSYSPELIVHPLLDSSNCAKEIEEWLPRLHAIVLGPGLGRSVGVLENACSVIQQAKERRLPLVVDADGLFLVTQDPQIIAGYDLAILTPNVAEFARLYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNZ0</accession>
    <name>A0ABY7DNZ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGRB2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_022788</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ98415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="145" mass="15555" checksum="4D967E3C5F16D442" modified="2025-10-08" version="1">MLGCDFLADSVESGVIRAFVGPALAIITINAVILVVVMKTMFGSHAISQKSTSGKSKMAIRCLLILLPLTGITWLLGLYVNKKHGVGARKSRKNSSSLTNTQSSTFESEEKQNVYSGVIITSSKINENDDKTSSTLQTDTPSSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPH5</accession>
    <name>A0ABY7DPH5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="869" mass="97730" checksum="F1BC4E2FFFC0FA1E" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQP3</accession>
    <name>A0ABY7DQP3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="155" mass="17728" checksum="D0DA07F036F87BA1" modified="2025-10-08" version="1">MKTSFALTRGREMTGQQRVTWFLAMPAWAEVNNAMHELTVVNYTTGEQNKHMTEARQAPCVVVSRLGSMNKLLYMLTKRGPSETSSWLGWMDKPLTSNHLKHSIRSDDWWRSSTGGSSTYFPATHEIWYHCSNMSCAITHQHCLTPNCCFDSHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQU7</accession>
    <name>A0ABY7DQU7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="12">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DNA 3'-5' helicase BLM</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MAR_023317</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">MELC-2E11</strain>
            <tissue evidence="18">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="12"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="648"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="812"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="15">
        <location>
            <begin position="1110"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="162"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="470"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="589"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1193"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1194"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1260"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1296"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1329"/>
            <end position="1339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WAQ98944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1339" mass="148247" checksum="8AB62D5BC0C548F0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRS6</accession>
    <name>A0ABY7DRS6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DPGN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_023662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053265">
        <property type="entry name" value="Serpin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21131:SF0">
        <property type="entry name" value="GEO10195P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21131">
        <property type="entry name" value="SERINE-TYPE ENDOPEPTIDASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00282">
        <property type="entry name" value="KAZAL_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kazal-like" evidence="2">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="2">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="2">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="2">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ99289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="402" mass="42741" checksum="3A228AF4C0C2F935" modified="2025-10-08" version="1">MTDVLMYAFGMNKQSVGEFPTLCIENSIVRHGISKQSNGQCPTPCICTLDYTPVCGNDDVTYGNDCQRECKGVAKKHDGECAPACACPFNYDPVCGNDGVTYPNSCAMECAGVSKQSNGQCPTPCICTLDYTPVCGNDDVTYGNDCQRQCKGVAKKHDGECAPACACPFNYDPVCGNDGVTYPNSCAMECAGISKQSNGQCPTPCICTLDYTPVCGNDDVTYGNDCQRLCKGVAKKHDGECAPACACPFNYDPVCGNDGVTYPNSCAMECAGISKQSNGKCPTPCICTLDYTPVCGNDDVTYGNDCQRQCKGVAKKHDGECVPGCACPFNYDPVCGNDDVTYPNSCLMECAYTEKTATVSELAGSVVETIVRKTARARNMVTAKPDRSPLSTGRTNTQTTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRV4</accession>
    <name>A0ABY7DRV4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RIAD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="122" mass="14148" checksum="D960CE99D7B939B2" modified="2025-10-08" version="1">MADKDPDHQKPQENSPHGMEPYDLGGNGDLGALSKEQQEKLNKYKIKTRIENEKYLREHPEVECLVSGFLQYVNKHFTDPDLPTDVERKLEARQQKIRQNRFLQKMVLLAPGWKAAHSNLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTY3</accession>
    <name>A0ABY7DTY3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="333" mass="35375" checksum="02301B24A14A8C0E" modified="2025-10-08" version="1">MRLESASTRAVVFCSSLSISSVAIEEGSPVIMATAGTRIGSKGSIDSKGISGTEGSKPEALRELQTLKILQAVQVLQALKVLQALKVLQALKVLQALKVLQALKVLQALKVLQALKVLQALKVLQALKVLQALKVLQALKVLQALKVLQALKVLQALKVLQALKVLQALKVLQALKVLQALKVLQALKVLQALKVLQALKVLQALKVLQALKVLQALKVLQALKVLQALKVLQALKVLQTVQVQQAPNVLQGLNIFQALKVLQVTEALNALHALAVLQSQITSTSGKDGSNLATEDSEQSTKVESNGIQTEGLKNSVSNGHTVTAGDGDKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUN1</accession>
    <name>A0ABY7DUN1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="66" mass="7463" checksum="F12B12465E3255CC" modified="2025-10-08" version="1">MMLSGGLPEIIVDKRDHGIFCCHKKRCSGVHPNVLTLKMMLGIEGKLRFCMCSNTHIGKQLIVFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUV9</accession>
    <name>A0ABY7DUV9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GLD2A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_024256</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="11">
        <location>
            <begin position="178"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="10">
        <location>
            <begin position="273"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="73"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAQ99883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="373" mass="42262" checksum="EF3DE3D91BE7062F" modified="2025-10-08" version="1">MYNQGPSRGGNFQPYSHVVPTQFLFQNQQPQMGVGMPYSGQLPYQQPLNQGYSAGIVQWNNAPSMNFHGMGSGYGSSSSAGPSRTRSSPRVYPVPSSTRPRDQYSGMPGTSRSHNATKHIRNTTRLRPNPLVSTPLKRGHVGGEKERKDEPDMKKKRVVDKLRATLPPASKNDTNANITAEIWKYFERNKQSDSMYERKVDLRNALYAVFKEVFPYSGLYMVGSSMSGFATQTSDMDLCLMVTAQQDLFNFGDDVRNLQMNVKIEFKSENTDSLGDLFLGFLKYYTHEFDFESDVASVRQGIRLPVHLVKTWTRPAELTMWKCLKVEEPFDKSNTARSCYDEATFARVQRVIARSYRTLCVKRDVNALLSSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVW2</accession>
    <name>A0ABY7DVW2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="143" mass="15959" checksum="38AF4762676DED35" modified="2025-10-08" version="1" fragment="single">MTGGLTMKINLNSVKKAEEKAKKARQRKPAPMRPKKPKERKFGLKEEFKGGNLSDEGSQELLPARELSSRKAKDVKAKYVVDSDSDSDTLKPIRKPGEESASEHYDSDDDPAWTPAFDGDTKKTNTLDLSLEGKRKRSKGKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVX9</accession>
    <name>A0ABY7DVX9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_008421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="198" mass="21667" checksum="C49B3522A3C20AA2" modified="2025-10-08" version="1">MPATNFTWGRSEDSPIFQVFGGKRKSSLGEQDSSITTKSKRQCTEYHVTSLSCKGGEESEMESLDTQPRPTDQGIPNGQYGYMACPDMVQPCRHLAESQVWNTRVPPLPDSSGDHGNNNNNNCGIFNNNVSGFNAGAELNNNQNDMIMDLNDEVYSTAAPPQNLNPFPNTTPIPPHIPGAHKGVTEVLHRELYAANTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXV2</accession>
    <name>A0ABY7DXV2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR02572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="462" mass="51613" checksum="8A18B1066A3AF547" modified="2025-10-08" version="1">MTQHFGSGFPVPRNDFTMMNNNYMPQRNIVSFTGRTGQLNGLRSPQILHNTASQPNADHSPNNIAEPLLVQGIKNQSQVLDIDFDCDSTAQIPNLMCDHQGPRQSQFISCSNSINPVEAPVLSPQSSANVNISSYPSNLTSFTFTSPMQSCIYAPALTTWPKTRFPQSVLTGRMFAPTGCSATWQHVVPQRMPWQTTAPLVPNQLGINVFTDFIFFYMKQQYLNHVFHGITQHPHSKLHCPDLQFRRSCAFLQWICKQTKEETSSGRQGLRIHATSPPLGHTGASHALGNTPDIITAANQENQQNSSCYQQYQQQQQQQDFSQGGYLTTQWQNYQDLENRLSLMDEDLLDAEETPMSSGSTQRRLHVNIDSLPRAIETRPLVPKAILDKIMNPCRDLVLWSAPGNKLQEKTDEKGDSEENTVDSAACKAESGLPGQAGIEVSDMADDSMEVEAEYIDEDFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZ85</accession>
    <name>A0ABY7DZ85_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_009610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR03052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="191" mass="22375" checksum="B1AC0ADAB6BCE7F8" modified="2025-10-08" version="1">MLSNVIVGRVLKKYGLGAYARSVLGISRRYMYRKGRSVRPAGVISRMKTKVKAFLERDDKQATITRNGYESEGNKISYSMFCKLRPFWIVKPTEKDRDTCLGQLHENLNYKIQTSYKENMVHSKDANVLINEIVCTQENKECMYRECRQCEDKQLSFENADGKQVLWNMWKNQRIDKEKDGKKKVVNKTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZP4</accession>
    <name>A0ABY7DZP4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_009773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="109" mass="12024" checksum="84BA8CF6BBC0FD6A" modified="2025-10-08" version="1">MAFQFIIYDMFALNNGKRFNTDTNIIVLSDGESTYDSPPEANTLKEKGVTIFTIGTNIHSNLSFLQTLASSSKHHFSLYGRQDIDVIKDILAIAGIGYSLPVTEPDCCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E116</accession>
    <name>A0ABY7E116_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="79" mass="9060" checksum="5BFDFD0A1B8FEED5" modified="2025-10-08" version="1">MVVMETLNTFQPRTFTPAFLGGDTEGDRYRPRAYTPAPGETAGGQTDGQKFVPHTFTPAYISEELDEMYEEEERQRPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E334</accession>
    <name>A0ABY7E334_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_009761</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR03203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="238" mass="25650" checksum="9E006F92FFB62F11" modified="2025-10-08" version="1">MTEVDLNMFFNRQCQFYTYAGSTTTPPCHQSVRWIIMKDPLMVTERAWFRLTGLQSRGDFNSRFGNYRTTQPLNDRMVEANFMPENGPVRPSPDAEIIAMMARPNMLVLPSPDAPRSAMMAARMTDVNPGNVTADAAGVSSMATMAGGGAAPPMAMGGILRSSMPIPPGSPMSAMMMMMTPALNANVGRIIQDFMMRPRGSRGTGPGVMSSGQGMSGMMSPMEAMGSGMPPMMLRTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3G1</accession>
    <name>A0ABY7E3G1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TSN9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_009604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF527">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR03046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="200" mass="22020" checksum="DFA82CE111D5FE51" modified="2025-10-08" version="1">MVSKTALKAFMLIISTVLFLCGAIIMGIGIWAVADKIFISDIVGNSLYRSASYIMVVVGACIIMTSFIGCTGAVLNNKGLVFFFVLVNGQMFVLLMTAAILGAVFRDNIEGDLQEDMKRGIRSQYGTSVEYSEENRDITQAWDMLQQRGCFFAAREFVVEQANILLGIGFSFCVFLLTAIVVGVMFILKLGEDSRGSYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4L7</accession>
    <name>A0ABY7E4L7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">POL5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_020317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd03714">
        <property type="entry name" value="RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="399"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR04948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="652" mass="74573" checksum="0F96EEFA8D9A224F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EB50</accession>
    <name>A0ABY7EB50_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF3">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="183"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="383" mass="44201" checksum="88393C91BF4A2D4E" modified="2025-10-08" version="1" fragment="single">MQQVLYHEVSKESTACLLKTKVTPSQRVNDKPHETWVCIDKKGGHVIRARCTCKAGKKVQPKPVDMINFDNPKPLRKKRRQRVLSTSVENDDGFDAAEALRSLKRICPSACILTKGDSDTDTASEDEDLPPVLSRFHEVEHESLSPTDLEDKFQRFVRDFQVRPQQVMNLEAMTKGQQDSVLWQRQRRGRITATTAHDVLTLKQATTKSNVLKKIMKYHECDLSRFDAIKNGRQHEETARSMYSDKMRQSHENFNVSDCGLFVDSTFPFYSATPDGLRQCLCHGKGLVEIKCSYKHRDSKIEDIKDQTFFLNSDNKLKTNHRYYSQIQFQMYVSGKTFCDFVVFTYKGITVPHDPEFVNMLIKKCTDFAIHDLVPEIIQHKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EC22</accession>
    <name>A0ABY7EC22_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ZN136-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_022038</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="517"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR06669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="588" mass="67382" checksum="03E6928E1D1B8436" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ED90</accession>
    <name>A0ABY7ED90_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LPLT2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_017943</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45692:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45692">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16489">
        <property type="entry name" value="GAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="652"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="682"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="739"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="8">
        <location>
            <begin position="433"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="615"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR07985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="775" mass="85221" checksum="C7B0CF4AD7F4F246" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDR1</accession>
    <name>A0ABY7EDR1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TRPM3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_016900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF1">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="227"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR06942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="557" mass="63596" checksum="4A06389E6749612D" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EED7</accession>
    <name>A0ABY7EED7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein kinase 40</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MAR_017250</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">MELC-2E11</strain>
            <tissue evidence="18">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd13974">
        <property type="entry name" value="STKc_SHIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024236">
        <property type="entry name" value="Ser/Thr_kinase_40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024104">
        <property type="entry name" value="Tribbles/Ser_Thr_kinase_40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961">
        <property type="entry name" value="SER/THR PROTEIN KINASE-TRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961:SF16">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="328"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="283"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WAR07292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="745" mass="82646" checksum="672A0ECBBAA5C119" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEP8</accession>
    <name>A0ABY7EEP8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="59" mass="7069" checksum="2FB89A84F4100A56" modified="2025-10-08" version="1">MLKIMERCNNARTNWTANTQNNNFNNFNNNFNLNFNLNFITHDINNNINDKFNYTGHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFN9</accession>
    <name>A0ABY7EFN9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="13001" checksum="FFBC82F7941F99FC" modified="2025-10-08" version="1" fragment="single">MMTSDQQKVKNVRFINGDYLKHLGHRTIYCDSDSVVFTSSQRQWEPPLGDYLGELTDEVPDMVTGKGSECVTVVDEHKIARNPSTGHLITERESKEYKIVFDKRIIGEEYNTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EG27</accession>
    <name>A0ABY7EG27_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZBED1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_017704</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="238"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR07746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="298" mass="33784" checksum="B05D012C1CC72DAF" modified="2025-10-08" version="1">MYQNTDKQHKLVQDVSTRWNSTYEMLARYVEQHETVIKILSSSDFRKNVKGIVPLSPDDVSDLELVIKVLALLKQITTIMCDTKIPTIPLILVFKMRIINALRAEDNDSELVCSVKNAIRVNMEKRYTNLETEEFLYIATALDPRFKCLPDLPEVKREELYSKLADRAEVIDIQTESTGHDVTIATPTSPRAGSSSGSLPSLPRLPNLDENQNKLTEDVYITNTDPAVSASEQTRVEVEKYRSRKAAPLKSIPQDWWRQHEEEFPRLSRLAKEVLHIPATSVSSERVFSVAGDIVTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHJ8</accession>
    <name>A0ABY7EHJ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NOX3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018346</name>
        <name evidence="4" type="ORF">MAR_018375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF191">
        <property type="entry name" value="FAD-BINDING FR-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="2">
        <location>
            <begin position="4"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR08417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="122" mass="14357" checksum="82F36944D9609076" modified="2025-10-08" version="1">MNAFEWLHDLLKYYDRQMADSGMNDFLTYYVYLTRGWDRNLAKTIVLHDEEIYDPITGLQQKTHYGRPNWDQIMPTIADKHPGTKIGVFFCGPKVLSSTLHKACNQHSSKEGARFYYNKENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EK29</accession>
    <name>A0ABY7EK29_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCYL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_034596</name>
        <name evidence="6" type="ORF">MAR_034650</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd20540">
        <property type="entry name" value="CYCLIN_CCNY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012399">
        <property type="entry name" value="Cyclin_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028934">
        <property type="entry name" value="Cyclin_CG14939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="187"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR09520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR09574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="356" mass="41026" checksum="E9795A6C52D1AA6A" modified="2025-10-08" version="1">MGNKNSCCGFKQSKKSRDEAYQPSSNNVRNEDSSDNARHQSFSSIPGDGIQHILDRENLPEDNLKDPSNNPLEKTMFYRRSHVEISKNNKNRRKSQYDDLAHIQNGGPYGELKKYSSCSTIYIDDSISQPNLKNTIKAVTLAVYYHIKNRESERSHDIFDEKLHPLSRETVPDDYEKRDPEHRVIYRFVRNLFSAAQLTAECAIVTLVYLERLLTYGEIDICPCNWKRIVLGAILLSSKVWDDQAVWNVDYCQILRDTAVEDMNELERFFLELLQFNINVPSGVYAKYYFDLRALAGDNDMSFPPQPLDKERARKLEAMSSTWEDNLKMLSKPKLARSNSLDGVTHSHRSSIAILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMF7</accession>
    <name>A0ABY7EMF7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="509" mass="58313" checksum="A2097894E19059D3" modified="2025-10-08" version="1">MEGDIFIKTLVVNMQRSFTIHGDTGEFRLEFPKPRLMERAGVGARSARSLPWVENEKEAFQHHAEYLKRLSKLREELIQQEQSNLANALDRLKMRSYGREYVYSQPQREKKAKLRFSAQQENNPAKRNTLITTFEKFQRMRPKREPPTIMPLEGKSLIDTPPVTDRIDRHEKRGGGLYNGNDTSSERSVDENVRLNLQRLTSHPIPSIPRQRRNINRDLVLESSSIRRHSHPTPHDANNSNVAEERIAIMQRQKQKLLKLRHEARETEKLKLMPQSFRLDTLSDDDKMNLDKLKDYYCIYYVPGPPASPSDSENELHVHLPRIGVSSPCNHFENEAALTERSKNGKTVGFRIATDNFVPPTACNCNCRMYVAGNRVESSFDQTLIDESIFKTQEANAAEPGGQYVNIARKSTMSTSRTSSRNTEKSWSQRNSPGKKKSPTGSSEKMRIHVDMPAIVYNTVHSPEPTENTTGLVKAFKQKELRHREYCNLMEDVRELNKISETLSGGGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EN05</accession>
    <name>A0ABY7EN05_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="73" mass="8068" checksum="94BFCFB3477AA674" modified="2025-10-08" version="1">MSSQIDKGDVIGKISSPCIQFELIACMPRTGLFILLLICEVSNAVPNVFAEPVTSSPFRSLVGEFQNHIRVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ENR3</accession>
    <name>A0ABY7ENR3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECI3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="125" mass="13917" checksum="11A4FA3A5CA08136" modified="2025-10-08" version="1">MGHAFGAGAFLALACDYRLMRQDRGWLCWPETAIGLPFGDFLLQLSRTKIPPGQSQRDAILYSKRLDGPEAKRLQLADGLVEETKMAAEAKSLILGALGRNRLSRDVLHNTKKDIYGKELDMSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPJ2</accession>
    <name>A0ABY7EPJ2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CNOT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_025955</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CNOT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="12">
        <location>
            <begin position="385"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="11">
        <location>
            <begin position="679"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="11">
        <location>
            <begin position="788"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="10">
        <location>
            <begin position="956"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="9">
        <location>
            <begin position="1265"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="9">
        <location>
            <begin position="1327"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="13">
        <location>
            <begin position="1507"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="8">
        <location>
            <begin position="1828"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="560"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="632"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR11775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2177" mass="242714" checksum="28CAEA3AECEB875D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPX3</accession>
    <name>A0ABY7EPX3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PKHG4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_025485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd13242">
        <property type="entry name" value="PH_puratrophin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052231">
        <property type="entry name" value="Rho_GEF_signaling-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45845:SF3">
        <property type="entry name" value="PURATROPHIN-1-LIKE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45845">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="1027"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1129"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1324"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="726"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="782"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="840"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1332"/>
            <end position="1344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR11305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1367" mass="152981" checksum="E25892B9B656DC9A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQ85</accession>
    <name>A0ABY7EQ85_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="119" mass="13460" checksum="8228096048272AFC" modified="2025-10-08" version="1" fragment="single">IECTYDGCSLYETIFEKCPYGFECFTNGTHVMCRQTSKDLFDLVLGTVFGGTAFVVLLALFVVGTASLRRRVDHFKSKNYHDSTPNSLTINRKQGNTVSNLKRTRMVTKNDQYASINDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERY9</accession>
    <name>A0ABY7ERY9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TADBP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_026074</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd19609">
        <property type="entry name" value="NTD_TDP-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12321">
        <property type="entry name" value="RRM1_TDP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12322">
        <property type="entry name" value="RRM2_TDP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041105">
        <property type="entry name" value="TDP-43_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF9">
        <property type="entry name" value="TAR DNA-BINDING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18694">
        <property type="entry name" value="TDP-43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="110"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="197"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="266"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="350"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR11894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="418" mass="45918" checksum="C1AD581B958B0FFF" modified="2025-10-08" version="1">MTTFVRVTDDESELEIEIPTEEDGVDQDGTILLTSLVAQFPGACGLKYRSETGGLRGVRLANGSLYPPGGMWGDTVYIVNFPKESKRKVDEELENPVSSKMKKVETRKTSDLIVLGLPWKSTEDDMKAYFEQFGDLVLTQVKRDPRSGQSKGFGFIKFKDYEAQLRCLAARHRIDGRWCEVNLPNSHTEQDNNPTNRKIFVARCTEDLTNEELREYFEQFGEVVDVFIPKPFRAFAFVTFADPLVAERLCGEDHIIKTASVHISSAEPKAKEQQIERQQGRNRGGNFGRGEMWDNSGSGQDAGLARGNNPVQNKSEMNAMGIEPNMNNIGMNMFSSAMLAAAQAVFQGAQNPNSSSYELGPGFGGTRDSRSGGFNNDSASGQNSYSQWGNRSGGGGGYNNSSSSSGWGQGASGRGNWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ES55</accession>
    <name>A0ABY7ES55_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HMCT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_026973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047037497" evidence="1">
        <location>
            <begin position="21"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="102"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR12793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="243" mass="26662" checksum="A2A15D372444E347" modified="2025-10-08" version="1">MSFKLTVLFVFLLIATEAEANEKFRAKVYSGKEVTTSTSSSLGVSLIQCQTMCVLARRKCTSMICGYDIVSKTCSYSLDSEDDLITTNGITKVVLIPVDDACQTSEYLVNGAEPVSDAQITASTSYSLICDTRGARLNTIATDAHQGAWAAKIHDKNQYIQVQFNCLNHVLGVALQGKPPLNQYVTAYKVLFSYDCVNFRTIMDTNGYDKVSVIKKHTLNCSVFSAKECKPFVIAFDSSSVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ET43</accession>
    <name>A0ABY7ET43_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045976056" evidence="1">
        <location>
            <begin position="19"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="196" mass="21909" checksum="0E89DC777E5071D8" modified="2025-10-08" version="1">MLYMFVLTLFVACVHVEGISEVFCPSCSHVEFNETDVSTVDEGILHQVHESITLYNYACADNHVIPERCHEPPEGFVNKCQNATIDHVQPRWGWSLSEQGVKGLVRGCVQVPEGLPDRCRSLQTLSNQEKSLFVEWTGRQGFKEGHSMTGHSHKALTYILTGVSPSDKTNTTIRLTQKADSCVVSHDDDDDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETI5</accession>
    <name>A0ABY7ETI5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="132" mass="15193" checksum="C26563B3E7EBDDC7" modified="2025-10-08" version="1">MIEELQSDFDAHVQSTSFVEHLFVEQWQQTQFTELEEKPARRQCPPCTGLRQKSNCQIPRRGQLLKITCVDETLIAKSSIDLTRRFGGGGIVRFSKSEKFLADHLEFYSARRLNGIPGGFKCKLNELLQFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETU6</accession>
    <name>A0ABY7ETU6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_027455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046998280" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="36"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR13275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="231" mass="25078" checksum="62308FD9BFADC50B" modified="2025-10-08" version="1">MWLYQMTLRLILFLITVNFTWTRTATLINLGQGRCGEETELVCSGTGTFTWNIRKDSIIVADPAQLHDDIKYSVSVTSTSVTLTIHNTDVSDLGEYSCEVAYDGRSQANATLASVTSGKRLQLTVDKLFPASVSAVLSVNAMVRGGGANTPGAPQLANSITEESKLILRVDEGKPATVSCTSSGFEEDLLQLFISRRRRRLKRTGRYLCYSSAVSAAVASVCFSGWRCSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVU3</accession>
    <name>A0ABY7EVU3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="153" mass="17538" checksum="037841C554FFB993" modified="2025-10-08" version="1" fragment="single">IGKYECSPDKVMIITFVERALSSSSMTDVSKIQSCCHEEAGYRIIFRTMHAFNEGLKHVVIHATDTFGRLSSYTNRLIQSKWLLSMDSIWTWKEFSIHIGTFNIPEKLSSASEHVSDHDISQIERFVVMLHSRTSSYDNANAARKHMCSYGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWW4</accession>
    <name>A0ABY7EWW4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NIP7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_004548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="60S ribosome subunit biogenesis protein NIP7 pre-PUA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="UPF0113" evidence="2">
        <location>
            <begin position="96"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR14443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="144" mass="16863" checksum="3A114A21D51C4BF3" modified="2025-10-08" version="1" fragment="single">MRPLTEDETRTFFEKLSKYIGENIKMLLDRPDGSYCFRLHKDRVYYVREELMKRAENIARPNLVSFGTCFGKFTKTEKFRLQITALDYLAPYAKFKVWLKPSAEQQFVYGHHVMKSGLGRITENTSQYQGVVVYSMGDIPLKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0G2</accession>
    <name>A0ABY7F0G2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20956:SF12">
        <property type="entry name" value="FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20956">
        <property type="entry name" value="HEH2P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR14239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="727" mass="81758" checksum="0DD1AD863AC8B249" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4B2</accession>
    <name>A0ABY7F4B2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_031611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF540">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 99A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="149"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR17017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="355" mass="40275" checksum="938725F9B60A5B6B" modified="2025-10-08" version="1">MCNSCTDRTFRGGFCNESCGSSCYENEVGLPVEAIAGGGGVVVICIVVALSIVIRRSIRKPVSSQTMQNGNTTFQADIIKENETESKIKRKSSEQNQPATRQQANEPTSVKQQVSTHEETAFQNENGLEIDDESNGVLDTSSTDDHTYYNELGTSSNKSKIPIDQLVKYVDGKNHEAFVAEFEMFSRGLVKPYVESQKKENLSPMSKQLEDFSLFWKMIWQQRVEKIVMVTNLVENGEQYQFLHTAVVYSLTFDCKQIKGENFDQYMSNHSTQELNNQFNSFRTKKRYLEAQTPLPETVTDFLTLIVQERCSCIVSFEANMDKQKEQFVFCHGCVSEYLSSFDVYANFSEKTGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5M8</accession>
    <name>A0ABY7F5M8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CARTF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_031073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029309">
        <property type="entry name" value="CaRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048324">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47456">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47456:SF1">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15299">
        <property type="entry name" value="ALS2CR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21056">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="737"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR16479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="912" mass="104569" checksum="2C790CA4DB3EB4C2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F6V4</accession>
    <name>A0ABY7F6V4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGSA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_031693</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="4">
        <location>
            <begin position="421"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR17099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="700" mass="80233" checksum="DBD1067EBFF37A52" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F775</accession>
    <name>A0ABY7F775_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SATB2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_032642</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR18048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.710">
        <property type="entry name" value="SATB, ubiquitin-like oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039673">
        <property type="entry name" value="SATB1/SATB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038224">
        <property type="entry name" value="SATB_ULD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032392">
        <property type="entry name" value="ULD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116:SF16">
        <property type="entry name" value="DEFECTIVE PROVENTRICULUS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116">
        <property type="entry name" value="DNA-BINDING PROTEIN SATB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16534">
        <property type="entry name" value="ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51982">
        <property type="entry name" value="CMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="CMP" evidence="10">
        <location>
            <begin position="40"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="273"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="692"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="275"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="694"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="227"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="342"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="419"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="662"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="456"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="580"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="662"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR18048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="773" mass="86415" checksum="3BA30723E9764387" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F8G6</accession>
    <name>A0ABY7F8G6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPNA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052079">
        <property type="entry name" value="E3_ligase/Copine_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45751">
        <property type="entry name" value="COPINE FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45751:SF11">
        <property type="entry name" value="COPINE FAMILY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copine C-terminal" evidence="1">
        <location>
            <begin position="59"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="130" mass="14535" checksum="E7AFEDAA43F964D1" modified="2025-10-08" version="1">MAGEVGGRKSGRRSVFLESMSECEDVGEKVMFRTIADKFQSLKEVTTAIQNVGLKECGLIFGVGDGPWDMMNDFDDKISERKFDNFQFVDFNKVKQGARNPQAAVALAALMEIPDQYKYIKDLGLLDKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F988</accession>
    <name>A0ABY7F988_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAXC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="137" mass="15836" checksum="6E9523200D8F08B2" modified="2025-10-08" version="1">MRLNVYTRWVIFNDDMFKIQSTCPKYMKIPMRRKVESMLHAVGVGRHSKEEVHAMMVNDLKQFSAILGDWKYIMGDQICDVDCAAFGILSQVRWCTPSACPGNAFLQGGEFKNATDYMDRIRNEFWPDWGDIISKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FFW1</accession>
    <name>A0ABY7FFW1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ZN160-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_032710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR18116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="439"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="586"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="718"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR18116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="751" mass="85251" checksum="6595C0B237676282" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FG00</accession>
    <name>A0ABY7FG00_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="195" mass="21469" checksum="CF86B7F0B3109CEC" modified="2025-10-08" version="1">MNDIFCHQNGLKKAPDFYSSPSEPTPVTIILEPPGSKHIARGHWTILCPSRIRMSSPSLETWWTLLEPRPHTYMWPWLSTATPAGDTSALFVYVNKTSPFATDRATTASLLASETYSVCWVLSVVKYSGNLKRGLPNLSYRKWDRGAPANVNTFTIGGVLVQGLQEMASLFPSVVTPHTSDSTSNELSNSIHTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGD2</accession>
    <name>A0ABY7FGD2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FBX6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007397">
        <property type="entry name" value="F-box-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039752">
        <property type="entry name" value="F-box_only"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125:SF5">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125">
        <property type="entry name" value="F-BOX ONLY PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04300">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01198">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="145" mass="16594" checksum="181BE2FBEC16A5C1" modified="2025-10-08" version="1">MQELKLLEQDRDQKIMERLPDFEARREPPLGDLYAARFDCGAVYKMKVVLMSEKTEEFWSASPKDTNCRYSFKETLPPGRAWFQAKQTFTDYPTGIRYVGFYHEGKDTQFWAGHFGAKMTLASVILDFSHVTGLADSCDGGSKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIM5</accession>
    <name>A0ABY7FIM5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="157" mass="17669" checksum="7649B5037796BDFA" modified="2025-10-08" version="1">MLKIAQFLIPSNLEHLTDDKVEALYHTFQSDLPALDAEEFKGEIRRWNISGRSEDNPPTSIAETLAFQGHHAFLLFKLEDADDIDQEKSLTDWLIDQGVATPFNNERNIEVVFNKEVVFNKGVVFGVGVVFNIEVAFNKGVVFNIGVVFNIGVVFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FKE4</accession>
    <name>A0ABY7FKE4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTPRD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF534">
        <property type="entry name" value="LD27988P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="114"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="216" mass="25064" checksum="E2007397A98786DA" modified="2025-10-08" version="1">MTNSILYSNCYTPLNSDRNRKQTQSKGTNSTWLKIEPMQTYLNVGIYYPAENMQAMTKGSFEVSSSRETKKPHYVMRNLTIRYKKASGHPSEKTLSHMQFTEWDELKNVPLSIETFLTFLNDVEEIENKDGPILLHCLYEFDGASRTGLFCVVSMLLQKMAIEHEVSVLNSVRKVKVMRRLAIPNLDQFIFCHESIQEYLRAFDKDVYANFAGYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FL67</accession>
    <name>A0ABY7FL67_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PE2R4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_036622</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd14981">
        <property type="entry name" value="7tmA_Prostanoid_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008365">
        <property type="entry name" value="Prostanoid_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866:SF16">
        <property type="entry name" value="PROSTAGLANDIN E2 RECEPTOR EP4 SUBTYPE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01788">
        <property type="entry name" value="PROSTANOIDR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="53"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR22953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="499" mass="56011" checksum="D4A50771ABEC5CA1" modified="2025-10-08" version="1">MTRGPTALFDLPEMGLIETDDQNTTEALVVISSVKKHNSVVSSSIMFSFGVFGNLLAMIVLQRSPSDQKRKLFYRLVAGLTLNDLFGTVCLSPFVIATYVNDFKWIGGTLSCKYFGFMMVFAGVATSTIVCLMAIERLLCIRHPYMYYARLRKKHATFFLLGAWAFAGLIASLPLMGFGEIVLKYPYTWCFINYYTNNDVSRAYNYLFALLELCTISITVSCNGVVLYSLLKTKMRGISRKRSGDSRTFSGYSRRYTEFQMAALLIGITIVFSSCYLPLIIRIVINQTKLLPVNLQFDLLIIRFASLNQILDPWVYILLRREVVWKVGHAISTVFSRNSTDKSLDRLQPREPMMTLRTEEHNTCCSFCYHCLCDPPQLPRQGSVCSLYGDDKSLAMRTSPRLGSAADLTQALTITHTTNDIIRRDRIAKLRQQAASVQLGVPAEPYSKEKIVVCLQPRESIVKVLTNGKGDGKTVLSSKRYDTSVPDSESGDGSGMCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FM10</accession>
    <name>A0ABY7FM10_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Teneurin-like YD-shell domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_036929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.180.10.10">
        <property type="entry name" value="RHS repeat-associated core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056823">
        <property type="entry name" value="TEN-like_YD-shell"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25023">
        <property type="entry name" value="TEN_YD-shell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Teneurin-like YD-shell" evidence="2">
        <location>
            <begin position="5"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR23260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="299" mass="34057" checksum="101BBD194091892D" modified="2025-10-08" version="1" fragment="single">MYSYRSVVNVLSENGALVNSYQRDPFGNAIESVENVPSMFTFVGQWGVVDIEEIPDVFYMRTRFYDSNTGRFLSPETFGFSAHSTNLYAYCANNPVIYKDPKGTRPWCLRMLRMATKGAITNLLELGLNTPTNKRTFGGAAVDWAISGVVKPFKKILPGWEMDVESDVVCIAGKATQRWFNNEPYSWRDSSEEYGKKQLDRTQAVLEEKFPLFKQLNIVCGAVEKYLGYSGVPCDWKDRIKDLFYKLLDDIIIWIQSRDPNDMLGPDGYGPARFISKDLTLKYTIRFENDANATAPAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FM67</accession>
    <name>A0ABY7FM67_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR22021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="63" mass="6935" checksum="F1D9F96BB1F619A0" modified="2025-10-08" version="1">MAGFTENLKLTLVTYESDHSLSFMTFPLNLICRMRLPCGGQPSRPRVKEGTVRACDGCSIVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FML0</accession>
    <name>A0ABY7FML0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECE2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF232">
        <property type="entry name" value="NEPRILYSIN METALLOPEPTIDASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="222" mass="25598" checksum="D8B52C7451F12817" modified="2025-10-08" version="1" fragment="single">MAMLQINWSFYLNNLLTEGSGAAHVVKPETKVIVLHEGALKQVCNVVHENNSNDEKKGILERYVLLGLARSMKPFFDLTTFQPDVNHDKEMEAEGEHWRRCIFYTNKALGLATAAVYVNATTIDASLAQITTLVTYVKRAFKEYLLRKIWMDAKTRKNAEKKLDEMIEKVGYPSFILNNTFLTNLYTNFTIGDNWFNNLLNWRKFTITNMVNSLSKAFDRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FML3</accession>
    <name>A0ABY7FML3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF10">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR23448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22869" checksum="0FE77A7FBDB2E142" modified="2025-10-08" version="1">MWLVERLEQLQHQEGETVKPLPRQLGNGLQVRHRQQKGNRLYARCTACNTDVSIGSGGRNDLTRHLTSKTHLAKAEAISSTPSIKNAFFKPASNDPVVRAEVYFATFIAEHNLSFTDLVKVMFPDSEIAKKFLCRRTKWTNIVTKALAPVADTQVTRLCRNNKFSIMMDESNDQSDSKCVAILVRVNDSATAHLPLPIVHPKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FP36</accession>
    <name>A0ABY7FP36_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tetrapyrrole biosynthesis uroporphyrinogen III synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="131"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="200" mass="21895" checksum="5F2B9368FC191592" modified="2025-10-08" version="1">MSVGHDEDGPTEMCTTNPSVLLFRAPKDGDEDPFEKALKEASYSPFSISVLEFHFQNIDKLVTSLLDGQKFLAIVLTSQRSVEAVSLALQSMEDEECPKEKKRKLCLDLPCFVVGESTAKEGFTLSEVTKVALDYIVYFSPSGVQYTLDLLQDDTLPLKHSKIIAIGPSTQSELTKLEIQVHGTALNPNPAGVLAAMSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPN8</accession>
    <name>A0ABY7FPN8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NPC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_037766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF130">
        <property type="entry name" value="PATCHED DOMAIN-CONTAINING PROTEIN 3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="712"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="3">
        <location>
            <begin position="206"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR24097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="787" mass="88697" checksum="DBE9482089467D1C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPS8</accession>
    <name>A0ABY7FPS8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNAI3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_037904</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF5">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="578"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR24235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="874" mass="98482" checksum="9A714FEE624677CF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRU6</accession>
    <name>A0ABY7FRU6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_038546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="59" mass="6866" checksum="0CBFE8E19C056B1F" modified="2025-10-08" version="1">MQCPLIYEVTLSILLLCSMLIAVGITNDISRITFLWSDSDHLQFTEQWFIDNIVDKFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRY0</accession>
    <name>A0ABY7FRY0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BHMT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_010692</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR24988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103:SF18">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR24988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="346" mass="37799" checksum="2D1B95C2CA3F403B" modified="2025-10-08" version="1" fragment="single">LLKRLKNGGNLVVAEGYIFEFERKGYLQAGTFVPEVTIEHPELVMQMYEEFVHAGSDVVLAFTYYAHREKLRLIGRENELEAMNRAALQMARQVADKHGCLMAGNISNTTAYIPDDPESHAKVEQIFKEQVVIAAEGGADYIVGETFSHFGEASIALQAILKYGKGLPAVITLSPPATDTMIDGVTLADACKRLEDAGAAVVGLNCGRGPETMLPAIREIMKVCKGPVAALPVTYRTTPQEPTFFSLTIPGTKSRAFPLELCTCLCGRCHIEEFANQCREMGVQYVGLCCGNSANMTRIVAQGYGRTPPAARYAPAMEKHFIFGDKTKFKDTYTEGVRAHVGGDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTE1</accession>
    <name>A0ABY7FTE1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="746"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="774"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="913" mass="95301" checksum="2739AAF7BDAB63B1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVX5</accession>
    <name>A0ABY7FVX5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="242" mass="26791" checksum="50F86BEF23FC2051" modified="2025-10-08" version="1" fragment="single">MSREEQFIYFGQCKISTFSSDFASSGQLDPCNCSSYYQLTNGPTPTKERHVCDPSLFWNHESSECTAGDLVIKLGLCDPAVPWNRCANINEVGSLVIKNDCVRKGFYSPAPLPDQTAAYISPHTLPNHVQMANLQLAGLSLLAGVIITTLLTAVLLTFCAKHLRRILVPPPRYEHRNSQGDENQHSYDDIAENEGFKCERIDDSDVDAVKSQLVSCPRCLQQSHTAADHSHLVTVTSTHNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FW44</accession>
    <name>A0ABY7FW44_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_010655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR24951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="175"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR24951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="315" mass="34325" checksum="5F559517A25CD1F9" modified="2025-10-08" version="1">MYKRLPGKNSYSFRYFYRRLLAQPTYIASLGIPSPCTAQSLQAGRIFFSVANSNKQFIQCDAAGNARVITCPDQLIWDQNRQSCVYTLQGGVANPGYLAAVTVKLKKIIRLCQFVLKNENDCEFAGFLNGANPCTAQAISAQALFFSHPDPTKFIQCDLQGNAFVQRCPSGLVATNPCVNNALQALNFPHPSDASKFLQCGLYERMYVVQCPTGELYDQATSSCISPKAIVAQPTYIASLGIPSPCTAQSLQAGRIFFSVANSNKQFIQCDAAGIARVITCPDQLIWDQNRQSCVYTLQGGVANPGYLLAVTGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWW2</accession>
    <name>A0ABY7FWW2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_011458</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056865">
        <property type="entry name" value="CCTL2_WNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024678">
        <property type="entry name" value="Kinase_OSR1/WNK_CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24889">
        <property type="entry name" value="CCTL2_WNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12202">
        <property type="entry name" value="OSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="194"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="731"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="801"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="889"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1112"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1204"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1249"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1292"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1498"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1559"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="273"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="331"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="433"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="540"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="576"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="731"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="762"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="913"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="936"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="950"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="972"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="993"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1112"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1212"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1259"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1292"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1506"/>
            <end position="1523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR25754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1675" mass="185482" checksum="AE9932EF97566799" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXH8</accession>
    <name>A0ABY7FXH8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_012589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR26885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="277" mass="32256" checksum="D5308996FDC86CB2" modified="2025-10-08" version="1">MKSVDEESLTNINELRKFRTEINQYLDKRENELLADIDQKKRTSKTLLDELKSKCTNMKSSIEKLKSELQAQDDNSNQLLIVGKRAIKELKGLQAALVEVSRRSEVTRYKFYRDPATEQLISSEKSIGGLDEGESWSALAQQQRQQQTKQEQRQQDTMQQHQKQMKGVSQKGESISAVGQQERQQQNKQQPRQLETMQQQQKHMQGVSQKARDFHRATLWMDMTLWRVMFRLSAVSIEFPDVYILYRLGIVVTINSAAPRLGKKTFDLLMTFPRGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYX5</accession>
    <name>A0ABY7FYX5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="69" mass="7757" checksum="92333979625AA3CB" modified="2025-10-08" version="1" fragment="single">PLSAQTIVGIISGCLIVVLVLIIITQVIYSRRKANKDMRWRVSWRDVDVLKTKGSIISGFSKSRISLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZ33</accession>
    <name>A0ABY7FZ33_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ShKT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046840900" description="ShKT domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9060" checksum="964435C3803812A8" modified="2025-10-08" version="1">MVSFIILALVVTLASARPQTGSTTVDIIVTTPAGQPPCKDILTQCNLLDKDFYCKGEYFNWAFENCKNYCGLCNYTRHLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZM3</accession>
    <name>A0ABY7FZM3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FBP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_013362</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6 7">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6 7">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR27658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="391" mass="44587" checksum="4D2E78D6355D0C5E" modified="2025-10-08" version="1">MLTYPKDISMITLIELRMKDFTKKNHFVLLTPDLPTRSCSDKPKFLDPTPLQNDVLVYRPGDIVYLSFYATSRAATIRSFTLLDPPTNVRQSALRNDDRFRPDVYAIDITWSPVAADRGSKTICVEATDNFMMSTQHCVTLFVWDINPCDSLPCQNNGTCERQRYTDNYYCACVPDIDECEAQPCEHGGTCVDLVGSSVCLCKPGFTGTICQTGVDSCETLPCENDGICRYNESSGYMCECLDGWVGRNCGYRLENETFFLGNKTGMTDEYIHYSDCDCVLGSGRQEYCYMYTLNKHSGFGILAILLGILSSIILYFLFYCVFDGFHNRISQDRVQDEKDEASDKHPPQIEKSAPEKLDAPKQRRHHCWACEVKYNNAPAPLWYKKDYKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1D7</accession>
    <name>A0ABY7G1D7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_012753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR27049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR27049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="264" mass="30520" checksum="828EC74897021B69" modified="2025-10-08" version="1">MKSVDEERLTNINELRKFRTEINQFLDKREHELLAEIDQKKRTSKTLLDELKSKCTNVKSSIEKINSELQAQDDNSNQLLIVGKRAIKELGGLRAALEEVSRRSEVPRYKFHMDPATEQLIASEKAIGRLKEVESSSALGQQQRQQQTKQEQRQQETTQQHQKQMKAVSQKGESTSAVGQQERQQQKEQQPRQHETIQQQQKHIPGVSPKARDFHRATIWMDMSLWRVKFRLSAVSIESPDVYILYRLGIIVRAINSAAPRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3L3</accession>
    <name>A0ABY7G3L3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_002588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR29020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="125" mass="14109" checksum="837205E5495EEE9D" modified="2025-10-08" version="1" fragment="single">MQELENENDKLKREVAKLMESISKTSNFNKGQKPTAAGKEFLGMRRGKTDGDGAEDGAKIIIEQFEAQADELERRREECLQMRVLLAEKSIATHSIAKLSHNGQEEIANVDNELTMAYKSQRDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G3M4</accession>
    <name>A0ABY7G3M4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UCP5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_013828</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR28124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="255" mass="28498" checksum="1985FB74685CF0A0" modified="2025-10-08" version="1">MSLTIVDLKFSHDNPLFFIMNLRLQGLALHFSRAVKLFIGSLKHFVCSCVEPEHSSSSSVFNRTFPIDTTKTRLQIQGQRIDAKLSQVKYNGMIHALLRIFKEEVNVFCGIVAGIVSSSFANPTDVRMQARSSLSGKETMVRAFHDIFRQEGVRGLWRGVGPTAQRAAIVVGVELPAYDMIKKYIINHHIMGDTKETHFVSSFTAGLAGAIASTPVDVVKSGSTFFHDNFDSWLVEMCFIEGVMTDNYDRNAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G484</accession>
    <name>A0ABY7G484_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZN862-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_013898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF5">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="429"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="512" mass="56930" checksum="3AAF41276B8B0D7F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6N6</accession>
    <name>A0ABY7G6N6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S19A2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_014400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002666">
        <property type="entry name" value="Folate_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686">
        <property type="entry name" value="FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686:SF18">
        <property type="entry name" value="IP11787P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01770">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR28696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="114" mass="12756" checksum="30B8EB4A8A46B7C4" modified="2025-10-08" version="1" fragment="single">ACGKFQVANYVQNLWEILSPYQNYNPRKHHIYNGASSCAVLAVGFLPVNWSVPGTCQLVTTVICGLNAIFLLIMSQTSSIWVCYVLYDLFRSTYKIVLVKAAYSSDSKCSYPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6X2</accession>
    <name>A0ABY7G6X2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein quiver</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_003463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF20">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045268589" description="Protein quiver" evidence="3">
        <location>
            <begin position="18"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR29895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14517" checksum="ABE3B51DC359EAB3" modified="2025-10-08" version="1">MDFKYLVCLFFTTCTVSEVLSLTCYQCNSITTPNCRDPFSSKRVNTSGCIGVCSKLKINDEHFLIGGEIVRDCLPTSFVYGGDTCEQASAFGYSGELCMCNANLCNAAGLTSATWSSIAITAIFFTNLIVYWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G955</accession>
    <name>A0ABY7G955_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IIGP5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_003445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051515">
        <property type="entry name" value="IRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341:SF10">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="IRG-type G" evidence="7">
        <location>
            <begin position="206"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR29877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="555" mass="62376" checksum="C3660FA635222421" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9E2</accession>
    <name>A0ABY7G9E2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_033069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="485" mass="56160" checksum="0BFFD41D931D147A" modified="2025-10-08" version="1">MENNIRSKSKQDKAVVVIELAKTYTRHTIHASVEKSEETTVQTSEKYPYCSFQLNNDEIVFELGNLNLMALYNAKEQSRNKTNTTAERGTSQVSYVCFDEEFGEIGSYDVLQDGTICNNSRNTNQLEVGPLEYYIEQLLCCVFTKDFIRSYRMKYKYHYNMLYKDFEEQIRQYDFATADITLNCKHFVTKINQHHSMPVESLIHDSKYRDTVRYDADTSSLVFSQQVLEKIMDNFNFCQRLEQELQYNNGLLGSLACKEGETVTSDYTFGYVAIENFNKEQHSEQNKTSLCYNNTVEECAIWIFRPLIKKGQHITVHNEFIWSETITFTLKQNKKSIHEAHVMRSKFSNPQYINEEGCELAATIQSHPPAEGWPDEVEFQYTLAVTENGPIIRVIDLKAAQTLTAEFTYKLKTEFLKGPSSVAMQSPILAGLHPHSIKRRANHTYGIWNKTFFHAIPELYKLIEKGQLLHQGQIFSAAFFLNHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GB28</accession>
    <name>A0ABY7GB28_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DMBT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_033106</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1415"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="38"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="92"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="196"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="247"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="356"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="498"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="701"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="837"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="941"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="5">
        <location>
            <begin position="1124"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="1197"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="9">
        <location>
            <begin position="1260"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="1328"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1456"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="805"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="909"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1330"/>
            <end position="1373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR30564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1483" mass="157274" checksum="BB1D98BF052B524B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GC15</accession>
    <name>A0ABY7GC15_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RABL6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040385">
        <property type="entry name" value="RABL6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932:SF1">
        <property type="entry name" value="RAB-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932">
        <property type="entry name" value="RAS GTPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="672" mass="74330" checksum="85FAA843E1BD1C98" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GFS1</accession>
    <name>A0ABY7GFS1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="22" mass="2550" checksum="E0DECAB142633521" modified="2025-10-08" version="1">MMQALLVTDMMQAYLITDMMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D790</accession>
    <name>A0ABY7D790_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat-containing protein SMU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_006012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045184">
        <property type="entry name" value="SMU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="6">
        <location>
            <begin position="32"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="377"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ93541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="410" mass="45885" checksum="58BF7396B15BF94A" modified="2025-10-08" version="1">MFFTVGCSILKENKHGSRNRVGREEAGISLNTVDSVDGFISDITSGHWDTVLQAIQSLKLPDQKLIDLYEQIVLELIELRELAAARSLLRQTDPMIMLKHNQADRYIHLENMLARSYFDPREAYPEGQTKEKRRTAIAQALSGEVNVVPPSRLLALLGQALKWQQHQGLLPPGTTIDVFRGKAAVKEQEEEKYPTQLNKTIKDNFMMMDEAVLCMCFSRDSEMLATGDQGGKIKSGKTLKEFIGHTSFVNDSVYTQDGHHIISASSDGTIKVWNFKSQECQSTFKSFGGQSGADITVNSIHPLPRNAEQFVVCNRSNTVVIINMQGQIVRSFSSGKREGGDFICCTISPRGEWIYCVGEDMVLYCFSVSTGKLERTLTVHEKDVIGISHHPHQNLVATYSEDGLLKLWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D8N5</accession>
    <name>A0ABY7D8N5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF18">
        <property type="entry name" value="SHORT-CHAIN COLLAGEN C4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ93729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="177" mass="19558" checksum="12A9FF7F96AAC160" modified="2025-10-08" version="1">MELQIVLLATISLMKAKEETRFIDSSDFERLMLKLQIRTCGGEGHPALQTTSSSIKVYGAEYEFDFHHDGVSKLFGQNLNDEDAPCAVFKSPRATSVKIPKECFSGWTKEYKCLIAGDYQHASASEFICLDERPEMVVGGAVNINGKVFFLAEAVCGSLPCPPYVQGRELTCVMCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DCU2</accession>
    <name>A0ABY7DCU2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_007589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="501"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ95118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="585" mass="65191" checksum="12827F3F86D5E5DC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DE64</accession>
    <name>A0ABY7DE64_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PYM1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_007101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pym family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="3">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ94630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="203" mass="23044" checksum="FE936C7026C2BAEE" modified="2025-10-08" version="1">MAAAPIERTGIVQDELTGEKFIPASRRPDGSWRKPRRVKEGYVPQEEVPTYENKGVQWQKSSMSSLPPGLNPDTAPQASNKQPSENTENMSKAAKKNAKRKEKKKQQDGQTVSVTQSGLPVVNISEQMARTSLNAKKDKVEGDKHDTLRKVRQLRKKVKQIEDLERRIETGELKQPEKDQLDKISKKQSLVDEMEELQLELDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DG01</accession>
    <name>A0ABY7DG01_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">STPG2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051291">
        <property type="entry name" value="CIMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580">
        <property type="entry name" value="SHIPPO-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580:SF60">
        <property type="entry name" value="SPERM-TAIL PG-RICH REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="361" mass="40269" checksum="3D13AE6E6DCFF04C" modified="2025-10-08" version="1" fragment="single">GGKTLANKSLRFKEQPIENPGPGAYNVDKYTEFRQTKSAPGMPEKSKTLGLVTSQLKFHRKPDAPSIPTPGKAFGYEECEDGTLKKQDPPDRDFSIGPAFYNVTHDTKPNETKTSKTYKGVHFGKLTSKRTDFVGKPGPGPGEYEPYMESQIQTENLNSINAEKPKHEANIPRYHEAIVKDTEKKAIPGPGKYDIKGTFEPQQPKVNTEGIEVEHPPFMSQSKRFTPLKTLQPAPGSYNDPRNAFESLKRVTGMKRSPFSQTSVRFTPQREPRIIPGPGAYNITGMGSESMRKAYIESTRRGVFGTTAVRINNIAKKEAPDLPGPNHYQVKEKPFQTRYAHLSSTFASVTTRLKDDSVSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGB6</accession>
    <name>A0ABY7DGB6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CASP3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1470">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052039">
        <property type="entry name" value="Caspase-related_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576:SF41">
        <property type="entry name" value="CASPASE 14, APOPTOSIS-RELATED CYSTEINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576">
        <property type="entry name" value="MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p10" evidence="1">
        <location>
            <begin position="18"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="99" mass="11767" checksum="7364A750DEF3BCBF" modified="2025-10-08" version="1">MARIVCNLQSDLFPSQSYYSWRNHQEGSWYIQALCIVLENYANKMELVQMLTQVNRMVAYEFESCSDEEFTESQKQMPSITSMLTRYVHFRPKKPDIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIC6</accession>
    <name>A0ABY7DIC6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fascin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_030131</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fascin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd23334">
        <property type="entry name" value="beta-trefoil_FSCN_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23335">
        <property type="entry name" value="beta-trefoil_FSCN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23336">
        <property type="entry name" value="beta-trefoil_FSCN_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23337">
        <property type="entry name" value="beta-trefoil_FSCN_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022768">
        <property type="entry name" value="Fascin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024703">
        <property type="entry name" value="Fascin_metazoans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052883">
        <property type="entry name" value="Hisactophilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33351">
        <property type="entry name" value="HISACTOPHILIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33351:SF1">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06268">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005682">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fascin-like" evidence="4">
        <location>
            <begin position="27"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Fascin-like" evidence="4">
        <location>
            <begin position="148"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Fascin-like" evidence="4">
        <location>
            <begin position="271"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Fascin-like" evidence="4">
        <location>
            <begin position="413"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ97441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="498" mass="55668" checksum="0D5506CDA9D1EC33" modified="2025-10-08" version="1">MKMAENGVNGHKSGVMEWKVGFMNNTEKYLTAETFGFKVNASGVALKKKQIWTIEQEQDHDFVYIRSSLGRYMKSDKYGTVTVDTEAEEKGEDAKFTVEYSKDGQWAFRHVERGNYLSGTDDIVKCFEKTPTSNSWWSIQLYIHPQIHLRNVNRKRYAHLNNDTNELECTELIPWGADALVFLDFVKGKYVLKSCDNRFLNRDGSLQEAIDNNALFMMEIHSGALAFKDCEGRYLTAVGKGTMKGRNKNISKDELFTIEDSHPQVQIVSHNGKSVSVKQGVDVSANQPAEEIEDTEIFQIEHNRASDTWALLASTNKYWSLQSAGTVQAKTAETEGAKSFFTIEWQEDGTVGIKGSDGKYLSNKQTGILFSAGTTLEPTDLFRITIINRPLLVLKSEFGFVGAKGNQFICSKAKYDSLTLQSAGSGLYTIQGTDGKYWSVGEDTLVYGDATGTKFQFQFCGGSMMAIRTHKGPFLKGEQNGLLKACAPDLESATLWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIM6</accession>
    <name>A0ABY7DIM6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GBF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_029854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="656"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1391"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1683"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1405"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1683"/>
            <end position="1696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1869" mass="208381" checksum="E57ED69E34EA28CC" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DK57</accession>
    <name>A0ABY7DK57_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_029564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ96874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="577" mass="64897" checksum="65EFE90ADB9A7B4B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DL79</accession>
    <name>A0ABY7DL79_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_022817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ98444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="134" mass="14795" checksum="9459E52F12A627E0" modified="2025-10-08" version="1">MELIKNNSGGLKLCLNGYMYTKKNTKKTSIRWECSQKRGLDCLGAVNTDIEVQTVLSSKDHNHEADFDKIEATKAVNVMKNGANISRGRPQQLVVDVLQPLPVEVRAAAGTTNAVKHSCDVCLRSSAWKIPRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLJ6</accession>
    <name>A0ABY7DLJ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_022937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="72"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ98564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="142" mass="16554" checksum="6393E9C5EBA9E94E" modified="2025-10-08" version="1" fragment="single">TCQYLGSSDGRQIGKFKVNCIHEKQNKSFQEKCFSFKDVNHEYEDYLTTIRQFEFLAWRDSEDTPMAVQPMLDILDAVNRWQPHLGETRPILIHCESGYRRSGVVAVLLNEVHRVQDNKGQINIVDSVKTMKQRNKDIVQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLW4</accession>
    <name>A0ABY7DLW4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BMP3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_030209</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd13763">
        <property type="entry name" value="TGF_beta_BMP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF270">
        <property type="entry name" value="BONE MORPHOGENETIC PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00669">
        <property type="entry name" value="INHIBINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0339">Growth factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="8">
        <location>
            <begin position="295"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="252"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ97519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="431" mass="49564" checksum="D8078C66C0310882" modified="2025-10-08" version="1">MASKTSCNEIQKYTFLDLTRHCISTILMFYSFIFPETVNGQPMFVFNLTSLSSAEKQNVSAEIHFYKRRKSRYNKKAHLTMSLHEIATGHTKDSGAMSVSLESYGWQRVDVSDIVQSCVSENTLHPQSLGLNFKMSKPHHNSNLLQLKRFMHKHSVPYLVVYSNDSKTIDEDELEDLSEKQKGIDHLHEAYLKTESLLPPRTRRSKRSLLDNNADYPIYQSRARSLSILTNEIPEDPEDYNKPYPIHAKTLQTHPGMLQTRKESRHKISDPRLIPLPGEYASKKKRRRDRKRNKRKKGQKDRMSNRLELPKEWDDLRELAEDEKKDGSCGRKKLVVDFSDIGWGEWIISPKSFKAHYCAGSCTFPLTKKMRPSNHATIQSLVNAVGIDPDVPAPCCVPDKLSSITLLYFDENGNVVLKNYPNMTVQKCACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNX7</accession>
    <name>A0ABY7DNX7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NETR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_022674</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050912">
        <property type="entry name" value="LOX-like_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45817:SF8">
        <property type="entry name" value="LYSYL OXIDASE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45817">
        <property type="entry name" value="LYSYL OXIDASE-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRCR" evidence="3">
        <location>
            <begin position="41"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="3">
        <location>
            <begin position="211"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="3">
        <location>
            <begin position="314"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="3">
        <location>
            <begin position="425"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="3">
        <location>
            <begin position="527"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="249"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ98301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="645" mass="71553" checksum="02130A84CD152C1C" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNZ5</accession>
    <name>A0ABY7DNZ5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UBCD6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_023790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="127"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ99417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="182" mass="21078" checksum="3F62C6791AA31975" modified="2025-10-08" version="1" fragment="single">MSTPARRRLMRDFKRLQEDPPAGVSGAPTDNNIMLWNAVIFGPHDTPFEDGTFKLTVEFTEEYPNKPPTVRFVSKMFHPNVYADGSICLDILQNRWSPTYDVSAILTSIQSLLHDPNPNSPANNEAAQLYRENRREYEKKVAAIVQESWNDDDDAQLYQDNRREYEKKVKAIVEESWIYHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQ70</accession>
    <name>A0ABY7DQ70_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_022873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751">
        <property type="entry name" value="SI:CH211-108C17.2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751:SF7">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ98500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="161" mass="18043" checksum="1E19C8921A96201E" modified="2025-10-08" version="1" fragment="single">MIIWCTDSAVRQCYRMALASVYLSGNNFSKIGLFSQFWGLQFSSSVSFYRVQNKCVVPVVERYYDSLKVDTLNDLKEQRLVVSGDGGMDSPGHCAQYCTYTVMNQADKKLIAMEVVDKRETNLKSGLMEAKTFSRAIDSMLRGGVEVEEIVTDAHPQISAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQS4</accession>
    <name>A0ABY7DQS4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">GRIA3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MAR_023435</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">MELC-2E11</strain>
            <tissue evidence="17">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="15">
        <location>
            <begin position="384"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="16">
        <location>
            <begin position="394"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WAQ99062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="827" mass="93230" checksum="AE8AE7383A39CBBD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRG0</accession>
    <name>A0ABY7DRG0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inhibitor of growth protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_023056</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd16857">
        <property type="entry name" value="ING_ING1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15584">
        <property type="entry name" value="PHD_ING1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028643">
        <property type="entry name" value="ING1_PHD_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF89">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="182"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="120"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAQ98683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="239" mass="27675" checksum="FA00CAE25F3F6B47" modified="2025-10-08" version="1">MHLQSMSILNQAAVEALCSATYLENYLETMDNLPDDLQRIVTQLRELDIQCRTILKDTEQHKETYLREESGQVKKKAFIAIKRALVRCQEIGDEKLHLLTLINEFIENRQRQLEQDRENLGNFFDPTSSSASVKDHDKEEIIPQPPVVNNIKEDKPKKKKKRKTKKDKEQSPIDPPIDPDEPTYCLCQQVSYGEMIGCDNDACAIEWFHFNCVGLTSKPKGKWYCPKCRGDTCKVMRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRL7</accession>
    <name>A0ABY7DRL7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_030285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd03587">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="344"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="408"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="477"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="510"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="5">
        <location>
            <begin position="640"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="166"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ97595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="691" mass="76553" checksum="F2AAA62C6F63313A" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DS70</accession>
    <name>A0ABY7DS70_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CTRB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_024321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="115"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ99948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="354" mass="38544" checksum="C6743826C6707272" modified="2025-10-08" version="1">MSDRPIVCLKSGPRPVNWNTPRHPKVRSHRDIHMCSVYAAVPQTRGKGETCVAANGVCSKAADCTGWVDIFDVSCGHNVCCLSAPSTLHPEPPSPNNDTCGLITRVPDRNPFARIVGGNEAVEGEWPWQVAFLDAAGDYFCGGTLITPEFVLTAAHCFVRHSEVGTRVVLGEHHLMHNTGNEVIRNIKTIVKHSKYVPTSHMDDVAFVQLDSPVDVSGHYVRTACFGSRDYTWTPADKCYASGWGYTNDYQADGHHLRHVQVTLVDTATCATAWGTNANVTANNVCAGNGLYGTCQGDSGGPLVCLRDGQYHVIGVTSFGYYTCSMAGYPDVFTRVTAYLDWITSYMLLMMAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DU12</accession>
    <name>A0ABY7DU12_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045426232" evidence="1">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="62" mass="6542" checksum="9FD392A54A34289A" modified="2025-10-08" version="1">MSLGPLCNVLLQLLSHFLALSDAIGCELGAHVANILLLIAKSSQVERKTVPGDLLSPDLANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUC9</accession>
    <name>A0ABY7DUC9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35245">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35245:SF2">
        <property type="entry name" value="DISINTEGRIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="762" mass="85961" checksum="B3B788A056615E40" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUR3</accession>
    <name>A0ABY7DUR3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Immunoglobulin I-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16359" checksum="6CEB7865ED36A26F" modified="2025-10-08" version="1" fragment="single">MLMESELRLVNATKVSSEKRSDAIQDKVKDFEEDIRTAPVIISLSKSEKYFYPCIQFKYIRGPAVNLTWLKYGKPFNVGKGSGDNSVNVTSEILNPNIAAEGGRHVVGGCLWFRIHNFHHYGMYTLVATNSFGSSNKSMIYEQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DUT4</accession>
    <name>A0ABY7DUT4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="179" mass="19961" checksum="94D71D811C8E11F4" modified="2025-10-08" version="1">MAENKLGGDCRPSNAVVPQQVGHQGTRPPEAIKESTPWVQEGTCDPRRVVSTSARGRDGEYQNSKTEIIFPPALPDITVEKDWVYIGAQDRKQPVSLPADEELDCEQSPVVSLCNPWYKDAGKSHARHSIAGFPGFPQYFSEKKRLQSFKKNRWPSHLPSPERMAKAGLFFKGGDDRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DV10</accession>
    <name>A0ABY7DV10_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="93" mass="10915" checksum="7C8E150F6F245529" modified="2025-10-08" version="1">MPSISLFPYAKIILPSDYVETDMFFSDITGNLHMKAKKDTIVFVFRWCVLDDMFLDNESYSVNVGGRKTYYFFVNLKCLDSYLEIIFDNLINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVR5</accession>
    <name>A0ABY7DVR5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_025158</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058796">
        <property type="entry name" value="COPS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25983">
        <property type="entry name" value="COPS2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="253"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR00786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="437" mass="51335" checksum="C53A641046D131F9" modified="2025-10-08" version="1">MSDDEFMCDDDEEYDLEYSEESNSEPDVDLENQYYNSKALKDDDPKAALDNFQKVLELEGKDKGEWGFKALKQMIKINFKLSNYDEMMKRYKLLLTYIKSAVTRNYSEKSINSILDYISTSKQMELLQNFYETTLDALKEAKNERLWFKTNTKLGKLYFDRGDFNKLQRILKQLHLSCQTDDGEDDLKKGTQLLEIYALEIQMYTEQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEYERAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQETKPYKNDPEILAMTNLNNDINEFEKILRTNRRNIMEDPFIREHIEDLLRNIRTQVLIKLIKPYTRIHIPFISKELNIDPSEVENLLVSCILDNTIEGRIDQVNHVLELDREGQQCARYNALDKWTLQLHSLHQAVINKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2A2</accession>
    <name>A0ABY7E2A2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="66" mass="7565" checksum="B321A42FEABBA039" modified="2025-10-08" version="1">MNDNRNQILLVWFQVDRIAGGNGNVYGLTFSGVTTVKRTIFPELDYKHHKRQTEIMNGSPQTQEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E311</accession>
    <name>A0ABY7E311_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BACD3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_009894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd18369">
        <property type="entry name" value="BTB_POZ_KCTD10-like_BACURD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045068">
        <property type="entry name" value="BACURD1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145:SF8">
        <property type="entry name" value="RE57120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR03336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="260" mass="29726" checksum="103B17298F02E779" modified="2025-10-08" version="1">MSGEHKTVIKGNSSKYVKLNVGGSLHYTTIGTLTKQDTMLRAMFSGRMEVLTDSEGWILIDRNGQYFGYLLNFLRDGTVALPESRRELLDLLQEAKYFLVQDLVKLVEAHLKRLGKDDVEPKCRIPLITSQREEQSLIATTVRLFDRLALRFSGRVLFLKDVLGSSEICCWSFYGHNQKIAEVCCTSIVYGEQKKHTKVEFPEAKIFEEALNCLLYENRHSRPDLELMEATRMGSGASASQSDEEIEEMLDRMRTSNNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3Z8</accession>
    <name>A0ABY7E3Z8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="91" mass="10283" checksum="086FFC9B229995AC" modified="2025-10-08" version="1">MFFFSVENHSDTSSDNGMLHIATEGVQYAVVHRQAATRWTETQQPHDDDSLTYAELNIKFLQEANARVLTKTKNTPTEYAELTFASTQKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4G9</accession>
    <name>A0ABY7E4G9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ADA2C-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_020281</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd14967">
        <property type="entry name" value="7tmA_amine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF125">
        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="387"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="54"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR04912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="527" mass="64324" checksum="56121DC05CF3EFA2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5L6</accession>
    <name>A0ABY7E5L6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46013:SF7">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46013">
        <property type="entry name" value="VASCULAR CELL ADHESION MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="95"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="305" mass="34034" checksum="2FC7357F4FA70026" modified="2025-10-08" version="1" fragment="single">MKRGTYRCEAINPDTRSKTTKTVTVDVRYGPDDVTLNVTNIHTVTEGDTVNDIYCSADCWPGCVFTWSSMTTRRQVSSTAVLNFRRAHRYDADSPDVLISESSALLHENTPLDLLCKAACIPAVYKYTGFLQRVHDIVVPNSHVGSLGVRDIISVNIPSLQLHDTGVYTCYVHNCIFGYNKQLIQTASRKVEVQASPRFLLEETNFAGDTSGNITIAIPFVSIPEYTSYSVIRHDGQLVSTNGKYTLHIRNESVYPLFYGQQVTLSGNVLEIIIRDLSEKEFGIYKMQIANDINTANFSIDVKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5N0</accession>
    <name>A0ABY7E5N0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NPHN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_020686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="77"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="165"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR05317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="670" mass="74089" checksum="833D3FAFA052DEAA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBW9</accession>
    <name>A0ABY7EBW9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CPXM2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_017471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046447764" evidence="4">
        <location>
            <begin position="24"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="135"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="5">
        <location>
            <begin position="190"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="8">
        <location>
            <begin position="465"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR07513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="561" mass="61561" checksum="6DF05698E60C7BB4" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EC75</accession>
    <name>A0ABY7EC75_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SRPX2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_021870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038877">
        <property type="entry name" value="THSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311">
        <property type="entry name" value="THROMBOSPONDIN TYPE I DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311:SF3">
        <property type="entry name" value="THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="4">
        <location>
            <begin position="125"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="3"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR06501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="772" mass="85360" checksum="00C0EC83130E8148" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECG2</accession>
    <name>A0ABY7ECG2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UCP3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_017656</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="133"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="231"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="310"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="496"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR07698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="570" mass="62648" checksum="EF08AEDBF7C0A023" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EE20</accession>
    <name>A0ABY7EE20_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_022018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045268552" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR06649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="71897" checksum="EB31748BE0A42EB8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFV0</accession>
    <name>A0ABY7EFV0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HSOP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_017760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058209">
        <property type="entry name" value="TPR_BSK1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25575">
        <property type="entry name" value="TPR_BSK1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="936"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="1459"/>
            <end position="1497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR07802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1639" mass="185921" checksum="4A35A5930D48CBDB" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EH27</accession>
    <name>A0ABY7EH27_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="232" mass="26559" checksum="C80DD02A94597A58" modified="2025-10-08" version="1" fragment="single">ATILISIKLSFENWTTKSQRQSLTVKLNLLSLELLPLSQRQTVVLEQSFPKSLTQAQVRHLYQNHTSVAFGLATIEQLFDWSKLVHNYSSCNQKDCASISSHEIQRLTPRKSGELWLCYVEEEGMFCLICRKHNIKHRQNLKEVFAASPILRVKVEAVTTHSTSTLYSSALEGELLQRLSNGETFTLIQLYCRETDRKRVVETQFMLCKNVVDNFKSENAEAIATFSAEGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EH30</accession>
    <name>A0ABY7EH30_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="214" mass="24517" checksum="856A4EC049BE08AA" modified="2025-10-08" version="1">MANSGKTVAESGLHCNHQISVTAKVTPSDFQDSREIKKKIIKHKKVKAKYAYPLSRGGIGVHIENQADKEKLLQRWPEGSFQKNTDSLIVHENKPKPLHTLRNKRNIPTRCFQCQEFGHIAAICKKVNFCENCAEPHEGKCKNKQNHFCGNVVQSKMEWTEWMIADKLTVKNESEYRVNAFVSRSITRAINEKIVTYKCEKSHRWPGIPSTNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHS1</accession>
    <name>A0ABY7EHS1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="208" mass="21922" checksum="46ACB79A96216F2B" modified="2025-10-08" version="1">MSKDVKDIHHPLGGAPLAMLAAQCNKITSKSPPPLADAAVGKGFYPWKKPEHSSAMDPANLLFVPQQRSSFTSTTSPSYVRPVSSVNGSGSYGNDLLYPSVSSTSSGSHNSSDSPQAASYLQKMHSETAWADTGISGMYSRVAGVTAQHYDAWPFGLGSNLKTEVGASVNPVSPFWDMHTGTGNLYPDVTSPSSGLHSQMSGYPAILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKB6</accession>
    <name>A0ABY7EKB6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36147">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36147:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="508" mass="59262" checksum="0A17AE51CDBDC695" modified="2025-10-08" version="1">MFNVRDKALVPYTTFNVRDKALVPYTTFNVRDKALVPYTTFNVRDKAFVPYTTFNVRDKALVPYTTFNERDNALVPYITFNVRDKAFVPYTTFNVRDKALVPSTTFNVRDKAFVPYTTFNVRDKALAPYTTFNVRDNALVPYITFNVRDKAFVPYTTFNVRDKALVPSTTFNVRDKAFVPYTTFNVRDKAFVPLIQRSMVEIRHLSLIQRSMSEIRLLSLIQRSMSGDKAFVPYTTFNVRDKAFVPYITFNVRDKAFFPYTTFNVRDKAFVPYTTFNVRDKAFVPYTTFNVRDKTLVPYTTFNVRDKAFVPYTTFNVRDKAFVPYITFNVRDKALVPYTTFNVRDKALVAYTTFNGRDKALVPNTTPFEIRHWFLTQRKMEEIRHWVPYTTFNSRDKALVSYKTFNGRYKVLVPYTTLNGRDKALVTYTTLNGRDKAFVTYTTFNGRDKALVPYTTFNVGDKALVPYRTLNGRDKALVTYTTFNGRDKELVPYTTFNGRDKVLVPYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EN86</accession>
    <name>A0ABY7EN86_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="51" mass="5790" checksum="5AC1BC8BFB2ADF2E" modified="2025-10-08" version="1">MSRHPPPRQPFRGCGYADPSYLERVTGELKAKGITEEDIDRREPIDGTIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EN89</accession>
    <name>A0ABY7EN89_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">XYNB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69349">
        <property type="entry name" value="Phage fibre proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="252" mass="26561" checksum="3886D911B843035D" modified="2025-10-08" version="1" fragment="single">MTGNNDTCMTGNNDTCMTGNNDTCMTGNIDTCMTGNNDTCMTGNIDTCMTGNNDTCMTGNNDTCMTGNIDTCMTGNNDTCMTGNNDTCMTGNNDTCMTGNNDTCMTGNNDTCMTGNNDTCMTGNNDTCMTGNNDTCMTGNNDTCMTGNNDTCMTGNIDTCMTGNNDTCMTGNNDTCMTGNNDTCMTGNNDTCMTGNNDTCMTGNIDTHMTRNNDTCMTGNNDTCMTGNNDTCMTGNNDTHMTGNIDTHMTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPH2</accession>
    <name>A0ABY7EPH2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CATAC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028015">
        <property type="entry name" value="CCDC84-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31198:SF1">
        <property type="entry name" value="CENTROSOMAL AT-AC SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31198">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14968">
        <property type="entry name" value="CCDC84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR11883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="494" mass="55502" checksum="E86DC67C715D5CEB" modified="2025-10-08" version="1">MNTNSTSFKQYKYCSLCKVNHNTGKKHVYSKRHQLILKNILQKFQTKIQQVKGTLFSPVAKDLEYEAGAKFWCYFCAIEVDKHDIMESCKVLGYGLLQHIASDEHKAGLEQFFWDNLVKKEMKPRYVLSIEDLSIFKKAAFLAVKKYQKASEADIKQAAFEIAAAETRRQEHLSEVSNQSKQITSQLEANTGNQSTTEAENQSISARGVKQSAEMRWPISPGKVNQSAKGGASRDGKQPGKRTVLAHGEGLSCISQPGGAEDGNVHSGAMPPWLLNDTPTSRGEIGPTLEDYQKHLHQEKRAKLPAMRVGANFDHQGTADTSWLPSFGRVWSKGRRLQSKQHFEKEWKKTNGKPQPSSTVTAESKIERIKSSTPPWEQPSCSRIEVIQDGSQSANQVQPYKKKLKQTVIDSEIDSDWTKQSAGKMPANIVPYKRKSQHFGTPDNKYVKMQTNTDQRFSSSSEVVPTGYKRQRKEHDNASSSSNLIQTPVLNLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPP3</accession>
    <name>A0ABY7EPP3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="225" mass="25983" checksum="6D3F10E1B4D59E95" modified="2025-10-08" version="1">MCLEANHIDYDKFNAMSAALNALKDDSKRIKEEVDRKKERSSTHVVKCKKELDDLEYRLKQKVEHSISMFKEDVQIFHEENIAAFSCISSICEENVSWAIQEESKLNEFVNNSFTGRLYLMSRNFEMRISKAKKQIKEAEYKNTFKNVCLKENMAALKCLIEDLTDVCELQEEVDGSDEVTTLSIGNATVENEKTRKELFEELIQAKLDTAIAETVIIFVDKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQP3</accession>
    <name>A0ABY7EQP3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR11459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="38" mass="4437" checksum="F06D1DEC8E5E030E" modified="2025-10-08" version="1">MPNLVICSAPHSNYERCMPMDQKRKCIQNVEQSTQRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUH5</accession>
    <name>A0ABY7EUH5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">HNF4A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_026546</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06931">
        <property type="entry name" value="NR_LBD_HNF4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049635">
        <property type="entry name" value="HNF4_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000003">
        <property type="entry name" value="Retinoid-X_rcpt/HNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00545">
        <property type="entry name" value="RETINOIDXR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="44"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="128"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR12366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="509" mass="55628" checksum="50348514C37DA8C7" modified="2025-10-08" version="1">MAQAKTTTEQRANKKQADGIGLQTISGSAVQTISTAPVGTQPLSQYCAICRDRATGKHYGAASCDGCKGFFRRSVRKNHAYTCRFQRQCVVDKDKRNQCRYCRLKKSVQNERDRISVRRTSYDDMGHQGALSVSTLLNAELLSRQTMAPVTCNGDELLHKRVATADDICDSMKQQLLILVEWAKYIPCFCELPLDDQVALLRAHAGEHLLLGVAKRSLSNSDTLLLGNDVIIPRTTSDPEIGRVAARVLDELVRPMREVQIDESEFSCLKAVVFFDPDAKGLSEPARIKAFRYQVQVNLEDYISDRQYDSRGRFGEILLLLPALQSITWQMIEQIQFAKMFGVAHVDSLLQEMLLGGATNNSAAASGQSASATSGGTCSTQVDAAQSSLPMSPSSMILNYRDLQGSEDEDNMTFTGSLNAGVMSLGTQSPPMSGVTFSSAPYIPDIQLENSPQHTVSPADPNLNMGPLGSPSCFNGHVINTTGSFNSSPVHAHEPFNLTSTAKFKQEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUT2</accession>
    <name>A0ABY7EUT2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="102" mass="11807" checksum="828263E90E1FC9FA" modified="2025-10-08" version="1">MESVNESRQPNTEFGSRLLSRRKTVKMLVTIVVVFALCFLPNHTLSILTYMEKLRGIPNLRIQIPERVPWDALSVLQLWENPNSGTRGSLPNDLFRDESFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUV7</accession>
    <name>A0ABY7EUV7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017191">
        <property type="entry name" value="Junctophilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085">
        <property type="entry name" value="GH28348P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085:SF16">
        <property type="entry name" value="GH28348P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="393" mass="44056" checksum="9D53A910A57A7E40" modified="2025-10-08" version="1" fragment="single">MANARTKAEQADQSAMKAEQDSDTARLKAKEFAPEFHQPGTDIIKKKLMEQNHNGGSPDEVYDFSHYDMQQNHNPHQRSKSLMMRDGPGGGMSPMFDQDPNRKISAQADFNYLSVNNPLLQTPNSLNPSQETVISNHSPHNRSPSLKIRRYSFLAGSQRGRGFSELFNSTILNDHFDQYSAQRDDSGLGREFLTHEDRIVSNTAHPSDTSPDSGVSEGVNDSSRPFVRRRTLPCIVNQDDPDKEAKAAVKEQAHSSENLSGKNPDRYIIENGIRKRVKGVTRNPQRISSKPSSSKGDLPKEYEIESQNALSRGGKHGSLPDITAIQKTDKSPISRQEAYKLSTARREELRRLQDIAERRRQGDVTVILGDLRDFVQQRQLLVLVIALNLSLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWT3</accession>
    <name>A0ABY7EWT3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SC5A8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_003855</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="666"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="666"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR13750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="964" mass="106186" checksum="DA8B2D32A1432E74" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXJ6</accession>
    <name>A0ABY7EXJ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HES1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_004102</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd11410">
        <property type="entry name" value="bHLH_O_HES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="16"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="7">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR13997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="406" mass="45572" checksum="5640E8E246BCD49F" modified="2025-10-08" version="1">MGPHTSSDKDEPKSIQRKLNKPLIEKRRRARINECLSQLKEIVLEANKGEPGCQEDYRLWKSHILGGPPSCLYANKPSKLEKADILEMTVDFVKSRLVSHSDLNARNATPPSTLSDGERKYLAGYSKCLEEVSTFLEQSTNTSHILQRNIVQHMSNKRDQKNCAFGVDMDEFHGIDDLTLQSNIEKQVPEQNPLGTGVNPEQTQSSNERNETEQGGTFQHLSQELKQHPSELQLSFKVSETCKQVPVLPVTPQCQTLDLSTVKPTLISEKATKRCANMKKTCIENNGQIHLEVKSMTQVRPSYILPPMLQPVGMLYGGQFLLLQINPTTVPQTTTHVQWNSSFVPDGNTDTPSSPSYSDILKNANDLLECTSSQNQTANPSNVEKRILTDKSNKLKDGNGHQWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXR7</accession>
    <name>A0ABY7EXR7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_004842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR14737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="88" mass="9869" checksum="E2CE4D4F3044C2DC" modified="2025-10-08" version="1" fragment="single">MAQLAARDKQSSRASYVSHRTDQPTDNSSSPIDFLMRQGHVHQTAQEFLWEAHDVGVSLSDAPLQAQALYQRGKLSLDRQAINFCIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EZA9</accession>
    <name>A0ABY7EZA9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="196" mass="22168" checksum="3D5C32DBC0078657" modified="2025-10-08" version="1">MFKLVRLHANNTNWTPSGEINDFVAFNDRPETKKQYNQTYGSTDRFSYSSELSLLHRAPCADLWLARVDRNSVCQKHMLGGNAVSRAVKGHILVDSALNSLLVEDLSTGLFRMKTAIVYSESMVQSGSHEMTHELQSSLGSNRTAQPWLQYMDMVAILKRYIKAERTGNLELHLKTIQEMLPFVAAVGHHIYLKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1E3</accession>
    <name>A0ABY7F1E3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATRAP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_005580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009436">
        <property type="entry name" value="AGTRAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16521">
        <property type="entry name" value="TYPE-1 ANGIOTENSIN II RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16521:SF3">
        <property type="entry name" value="TYPE-1 ANGIOTENSIN II RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06396">
        <property type="entry name" value="AGTRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00805">
        <property type="entry name" value="AGTRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046919599" evidence="7">
        <location>
            <begin position="23"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR15475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="118" mass="13313" checksum="88DC66FA5C8DD9BD" modified="2025-10-08" version="1">MNPPQITLKLLVFFHFVLTVWASQNGFLGLSYVYMNLFVLSLGVWSIVHHESAEPVFMFLICHVFSILQDIILLGINEPRGGSPSHGPYENIDTPPTAPAPTDEEQAYNQPYNSQEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F1J7</accession>
    <name>A0ABY7F1J7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CD11B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_004734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="387"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR14629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="576" mass="68639" checksum="C9B7E6EBE431C649" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4H0</accession>
    <name>A0ABY7F4H0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_031669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR17075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="76" mass="8064" checksum="2B9931E14C4CE68A" modified="2025-10-08" version="1">MAYIFAIMEEKVTAGPPVGAIAGGVSGGIVVIIAVAVALIFFRRRSTRLPASRQTKGNGNKTFQANITDEKNKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4L9</accession>
    <name>A0ABY7F4L9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11688" checksum="A6CEF5F3A9953ACD" modified="2025-10-08" version="1">MSVYKASRVYGVTESTLRDRTHGLQPTGDLPYAGPGPLFSKNEESQLVEHELDKVLKAHNLHESPESIWNIDETGLQTEHSPRKILCMQGEKANTVTSNRGQTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F5H2</accession>
    <name>A0ABY7F5H2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_032042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF147">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR17448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="123" mass="14676" checksum="F786F048A1C48FA6" modified="2025-10-08" version="1" fragment="single">MDVGLKRAGLKIRLHATLIQFSTRFTINLEHGDDIAFHFDVRFDSNVILRNSQQRGIVWGREKWECAWFPFTRDVWFEMAINVETSMFKVVVNNQHLFEYCHRLQSLERFDSLRITGDLRLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAE9</accession>
    <name>A0ABY7FAE9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045661967" evidence="1">
        <location>
            <begin position="20"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="180" mass="20524" checksum="C41F62B1B32C871C" modified="2025-10-08" version="1">MKWTLAILGVVAVTGLVQARTMTKRQSGGEPKWPAEWMATEGSILVKACPLAIGLVSKYAEYKFEKNDAETADKIEQGIRDIFPLVQCANLEATREFYEYSAEMKKEDPKNCEWFKYDPLPEVCEHLYKSVAEEADEFNAALNEIGLDNSAELDHGINRTLRLKVFFFLFLINIFCLFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FC67</accession>
    <name>A0ABY7FC67_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SC5AC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_000612</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR18774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="257" mass="29157" checksum="54383A30B347FCB2" modified="2025-10-08" version="1">MRNHKVQFRIDPDPRVRHTVWGLLIGGIFNWLPNCCNQSAVQRICSMKSIRDAKMYINILEPTFFLDVLDLSTYNYECRSCLLNIPFLVIYGVLLALVGLLLYAYFTLEQCDPYLSGAISNNNQLVPYFVMRVFRNVPGLAGLFIAALFSGALSSLSSGINSMSANTLQDLLIDVLKDAQQYKKTMIAKLVGMDREDPTEEEYIFPCLRGFWKIGYTKTSNQPVDAAEMSKTDVQLENTVPVENLEIEVYHDKTIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FCR0</accession>
    <name>A0ABY7FCR0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RHOQ-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_000399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR18561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="224" mass="25080" checksum="AC50F8C963678D57" modified="2025-10-08" version="1">MVVLRGDLIKCVVVGDPAVGKTSLLMNYATNRFPSQHVPAVFDNYAGSLEVSRRRYNLHLIDTTEQHSWRAGYRPGADPIATVHCAIRPILGGSKSLEYSYPGTDVFVVCFSVVKPETFTHMHEHWIPDIQARMGDTPFIVVGTQADLRDDPEVLRTLQVKGQSPVRQRDAASLCRKVGSVCYFETSTEMKKRLRRVMNDAFVSVFCPKAEFNIGCCLQPSNFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDE2</accession>
    <name>A0ABY7FDE2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEPHL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="274" mass="31333" checksum="C0777FA5FF979F66" modified="2025-10-08" version="1">MKGPCTNKVLEIDSSCLTYIYRSAVDLEKDFYSGLLGTMLICKRGKLNRAGRQRRVDREFFLNFLVVNENLSHYLTENINMFATSPATVDPEDEGFKLSNKIKERVTWHVYTIGPDIDNHHVTFEGNNFVFDGMTIDTLGLEQEGMFAWYNVNSCGRIRIQPGRLPKAETTRRYYIGAVNVEWDYAPTKIHFITGKSLFGPTSPSFIYVRNRSLLTVFREFTDNTFTQMKPHPENLGVIGPFIRGNVGDTIEIHLKNMATFPLNIVPKNLPFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FDM3</accession>
    <name>A0ABY7FDM3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="78" mass="8880" checksum="2ADE844490D03A60" modified="2025-10-08" version="1" fragment="single">MTILPFGAGISVLARRTSIHLSSILRSCLVQYKIQDRSVMVVEAVRTGTRKGTKVFTRKKTYSTQKVAFHHYIKRKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FE30</accession>
    <name>A0ABY7FE30_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ENOPH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_002248</name>
        <name evidence="3" type="ORF">MAR_002311</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371:SF1">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR20410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR20473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="243" mass="27327" checksum="13976725732A1C5D" modified="2025-10-08" version="1">MPPPTEKRTLEEAESILEGVKAVVLDIEGTITPISFVKDKLFPYIRENIETYLTSKFDDDETKADITALRDLAKKDKEGGADVVEIPDSTDDNEDAVVKAVVKNVIAQMDADRKSTELKQLQGHMWREAYKTKKVEGELAGWVAILVDRSLEQEDSIEIDEATRQSFQVIENLHDLFGDDDLDEMEGFDGQVKRVKLAANGEFDDDDEDDEDEVDDDGEEDEEAEDFAEDEEAGEDGEEEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FED0</accession>
    <name>A0ABY7FED0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FBP3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_002371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="85"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR20533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="242" mass="25839" checksum="5CA872E30CAD8779" modified="2025-10-08" version="1">MSEPIVAIRQSNGLNLKVSTSTAQTTTPDPCAGSLCLNNATCAGSSSGYTCKCLPGFTGARCENDVDECLHSPCDNNALCHNTFDVDACLTSPCKNGATCQDLVGDYTCTCPPEFTDKHCQTKIDYCDPSPCRNGGTCRLQGVGYVCDCPDDVIGLNCELPIQQPLCGRHGIIAYPTGLVLGAILCTFFHYLLRPRCCPATKRPSSAVSARSDSSLRDLTFTPPPRYSSLGFRKDTPSQSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FEN0</accession>
    <name>A0ABY7FEN0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_001249</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016239">
        <property type="entry name" value="Ribosomal_S6_kinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000606">
        <property type="entry name" value="Ribsml_S6_kin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="14"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="242"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="260"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR19411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="582" mass="65989" checksum="98B09A160718F33D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FG12</accession>
    <name>A0ABY7FG12_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">B4GT7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_015084</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF30">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="12">
        <location>
            <begin position="49"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="11">
        <location>
            <begin position="127"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR21110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="245" mass="28383" checksum="E83DBD858D044BAE" modified="2025-10-08" version="1" fragment="single">VPVLQRQSKIENILMSNGQEDISTEMSPCESYLLKNKENISLEKNDNQNWGPHKLAIIVPFRERFEELMEFAPYLHQYLLKQHVRHEIYVINQIDTLSLDCDYIAMHDVDLLPVSEELDYSFPGNGPYHIASPELHPLYHYPTFIGGILLITKKHFSQVNGMSNRYYGWGREDDEFYVRLKKGGLLVTKSKIARNSLSINRAPVTLLEVKLSCDFLRTPWCLKKEDHHLLDTVVTPPKSGMKRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FG84</accession>
    <name>A0ABY7FG84_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAZ1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="265" mass="28237" checksum="BFD10D80BFEA6C38" modified="2025-10-08" version="1">MAADNINSPDNNTKATNNIFNTADNNTKAADNNTRAADNNTKAADNNTNAADNNTKAADNKTKVADYNTKTADNNTKAADNNTKADHNNTKIVDNITNNADRNTKTADKNNKAAENNTKAANNNTNPADKIVDNNTVTADNNTKTADKSAKTADNNIKAADNNTKAADNNIKTADNNTKAADNKTKTADNNTKAADIKNKDVDNNINAADSNTKAADNNIEAVYNKTKATDNNIKTADNNIKAANNKTKTAVNNTMAAEKQHQCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGA7</accession>
    <name>A0ABY7FGA7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LECG-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="106"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="293" mass="31589" checksum="E06CC57DC96311CA" modified="2025-10-08" version="1">MTWADAELHCEELGGTLAAITTQDESSSIFAWLANEGVATGSVWIGGNDIAVEGTWEWSTGEELLIGTLLTEASSPSTTACAVLCLRRQSDGCSAEFRCPQDWIRIDLSCYHLATGRMTWADAELHCEEQGGTLAAITNQEESSSIFAWLANEGVVTGFVWIGGNDHAVEGTWEWSTAEEFAFEEMSKTSEPNGSTGENCLAIYMNRAGWADLALYLLFFLPDRNDTVTGTLLTEASSPSTAACAVHCLARGSDGCNAVRFRELSMGCQLIALDSSSPTEFAAISEWQLFVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FH20</accession>
    <name>A0ABY7FH20_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">THNS2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="413" mass="45917" checksum="414931FF90747FB9" modified="2025-10-08" version="1" fragment="single">GAMKYCSTRGGVSDATFEEAVFTGYAADGGILLPQEIQPVSMETLKAWSKLSFVELAKEIMQLTPEVAPVTRLKDDVTILELFHGRTWAFKDVALSCVGQFINYFCSKSKKHYTIIEHPVIPEARLSRRYGGFRGWISWFFCPEAALDGTSDDLDLVIKPVFMDGEFRARHLLTSINSINWARILMSPDCDKTVEIVVPTGACGNVTSGCIASKMGLPARLVCAVTCNDIVARAVSRGDYSVSAGVTPTLAPAMDIQIPYNMERIWHVFSGGDWKLVRSLMDQFELTGAVQVPADLRDKTYVVSDATVTATMRRLWEDGHYLPCPHTATAVAYHLHKWDSGNRDPRICIATASVAKFREAVEAAQLPVAADGRVDELLKRPTRYRDLEKDEDWDRAIRDAVEDINRRRASGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FH72</accession>
    <name>A0ABY7FH72_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="425" mass="47364" checksum="54013FB80B554DB2" modified="2025-10-08" version="1">MADTSLWELMYHPLRAPVLSRYHHVGAPIPSSKLADNILWEILLELLYHPLGAPATSRYHPLGAPVTSRYHPLGAPVTSRYHPLGAPLTSRYHPLGVPVTSRYHPLGAPVTSRHHTLGSPVTSRYHPLGAPIPSSELADTILWEILLELLYHPLGDPVTSRYHPLGAHVTSRYHPLGAPVTNRYHPLNWQIQPSGSSCNYQIPSSGSSCNQQIPYSELADTILWELLYLADTITWVLLYHSLGDPRGDPVTSRYHPLGAPVTSRYHPLGSPVTSRNHPLGALMPSRYHHLGVHVTRMYHLLGAPIPSFELADTILWEILLELIYHPLGAPATSRYHPLGAPVTSRYHPLRAPVTNRYHPLGVPLIKLADTILWELIYHPLGGHVTSRYHPLGIHVTSRYHPLGVHVTSRYHPLGAPVTSRYHSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHC8</accession>
    <name>A0ABY7FHC8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DMBT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_015562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRCR" evidence="3">
        <location>
            <begin position="50"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="3">
        <location>
            <begin position="151"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR21588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="230" mass="26188" checksum="F9B57D148DD55ADE" modified="2025-10-08" version="1">MLRLPTTTIIKPFWNIIEFIIELLDKRMSRTCVKYKVSNSSEGPNVLQDVRLVDGVGLYDGRIEVLYNGTWGTICRNNYRYQNSVVICRMLGASRQEETTRFGAGSGPIHFENLYCQGSETDLSQCTVDVEHTCSHSLDAEYRRPLNITGVRLADGTSQYDGRVELEENGVWGSVCHHYFDFNDGNTLCRMMNMSNPGTGIPSTLKSVIFFQRFCKLYQKVDKKRILGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIQ0</accession>
    <name>A0ABY7FIQ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">STAR9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_002469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF1">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="3">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR20631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="132" mass="14184" checksum="D53068309671CFD2" modified="2025-10-08" version="1">MSNIRVAVRVRPLSNKEQEDGSQEIVQVNENVVRIENIKVRGVPEFGDTARARARDFTFDHVYDSVQGNAPCASQAQVFNDLGAQVLHNAFGGFNACVFAYGQTGSGKTHTMMGYPASSQSSLNEAGTGTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJE5</accession>
    <name>A0ABY7FJE5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_016289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR22315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="779" mass="90740" checksum="165E7BB9A12413F5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FK35</accession>
    <name>A0ABY7FK35_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="117" mass="13048" checksum="DA9022ABF2595D8A" modified="2025-10-08" version="1" fragment="single">MTSYGTHEAFDDIPDVTFVCNNRTPNSLRATCIEESEPLNENGRANIKMQESPYADNRWGSEDDMLEYEDGPLCTCGPCKRRRALTGPEKGLIVLALVAFVVIIVLAAHMGWKDEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLM6</accession>
    <name>A0ABY7FLM6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="8">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_036794</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="8"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="10">
        <location>
            <begin position="104"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR23125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="307" mass="35120" checksum="AD25C042964854D0" modified="2025-10-08" version="1">MGCDESKPKMDTSESMFSDIKGRSEENGDKPRGKNYYTNPPVNLPQPGENSDAEGGSGGGKRVFALYDYDARTQDDLTFRKGDKEGYVPRTYVALEESLESHDWFFGRVTRKEAERNLLTKDNPVGAFLVRESESCPGSYALSIRDYDQNMANPDCAKHYKLRNMDEGGVYIVKRRQFKSMMELVDQYKVQADGICGSLVAPCSRAAPVMVDLSRDTKDAWEIDRNSLQLAQRLGAGQFGEVWKGMTNREVLQHIAYGYRMPKPLECSDAMYEIMLKCWDKREENRPTFEFMECFFDDYFANTELEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLZ8</accession>
    <name>A0ABY7FLZ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR23248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="182" mass="20907" checksum="4F0A0F64E35F9BB1" modified="2025-10-08" version="1">MQRKWRRRASFCMLSAVPVITERRPVKSALVKRSVDSDDDGHLPDAIIEKVARANTVHNEHSQILPEIRAAPCPIHTKKDHKDPLKTDGRSPRRLTTHEPHNQLNVHTSTNKGCRMDINIRIPEQFPATVRQPMLPKNMTSKEYVMTWLVHGSEPNGNNHFPEIIPRRKKSLKVKMPDVKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMD7</accession>
    <name>A0ABY7FMD7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR23360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="247" mass="27746" checksum="99DDE3634418886F" modified="2025-10-08" version="1">MTQDQGMKAPNIQYLPVAPRAEEFVIKRDDHRAVNTTVDGAGAVTLREAHRPRAGWPQPTDPPGIAGCTQAWHSPGPQGSLILYPHQETGRTGLVTAGIRTHFYLPVEEPAILGDSCFLCAACRNLNDLSIICGEGELDGGVDSPTPTVHTAKSLRLGWICLEWTCWIDNNIWAKKNRISWRKNNQQATVPFTRQPNFHFELLKDKISDIASFTIKCYTDNQMQHTSKLHEYFYVPVINRIEQIPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FMJ6</accession>
    <name>A0ABY7FMJ6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CTNA2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_016533</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001033">
        <property type="entry name" value="Alpha_catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914">
        <property type="entry name" value="ALPHA CATENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914:SF9">
        <property type="entry name" value="CATENIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00805">
        <property type="entry name" value="ALPHACATENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="372"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR22559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="947" mass="105501" checksum="933F777958E86429" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FND6</accession>
    <name>A0ABY7FND6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR20726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="386" mass="44052" checksum="9A97F5AD0D0B5A54" modified="2025-10-08" version="1">MYRECCHCKNKRLETNEDEDRKQVWVYFWQNRHEQRIIKDKTQNVQVTVKEKVHCTLSVLVDEMNEVLKSKYCRHVYNITHQHKQLNNLKDTLTDTECIVHIDFSENYACKMSIEVQGMHFGASRNQASLHTGVLYLKGRQPTSFCSIFNNTRHDPASIGAHLHPILQEIKILTQLNESAIAVKLFYITSDVITKIDEELSNVATIPVKGTMLIHQVICSSKSECIYVRDLSCFCNASKLCKCVIFRKVVLVKSNSNGQGVILGSAISSNSAIGGSSTSCIRTESADHTSTNDYEFSVEAVKKWVVGEYDGLPYPGIVQNVDHESVEVKVMHSIGKNRYCWPARDDIFKYDFHDVVTEFEGMESVTGRHMQLPFNVWDKVCKKLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQ07</accession>
    <name>A0ABY7FQ07_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ASX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_037979</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Asx family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026905">
        <property type="entry name" value="ASX-like_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024811">
        <property type="entry name" value="ASX/ASX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028020">
        <property type="entry name" value="ASX_DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13578">
        <property type="entry name" value="ADDITIONAL SEX COMBS LIKE PROTEIN ASXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13578:SF20">
        <property type="entry name" value="POLYCOMB PROTEIN ASX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13922">
        <property type="entry name" value="PHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEUBAD" evidence="10">
        <location>
            <begin position="255"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR24310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1065" mass="114357" checksum="CBD7558CB69B4049" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FR66</accession>
    <name>A0ABY7FR66_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_038194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR24525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="159" mass="18208" checksum="028D9207B8AFD5DD" modified="2025-10-08" version="1" fragment="single">MANPARKRKFQVTFILNRVEEATRYVTVKNEDNVKVKNIYLEDTTKKCKIALWRDLADQPVRPGDYVELSDCITNTFRNEVSLSTTSKTAITKTECPEETVTWEIESVCIEESTATMLLKDDRVVTAPVKSLLEAFPECMEEDLEQYLVSMCNPTMVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FR68</accession>
    <name>A0ABY7FR68_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RAB24-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_015690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR21716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="188" mass="20743" checksum="89D4A71AFFB2CF9B" modified="2025-10-08" version="1">MTCVDCKVVLLGNANTGKTCLLRRYKDKTFCELSQMTVGAAFLPMTETFDDVTVNLGCWDTAGSERFASVTRNYYRGACAAVICYDLTCVESFNGAQKWVSEMTAMVPECKLYLCGTKKDLIDSGNFPRAVPLARVRAFAEADDVQADIFQTSSKTGENIATSNGSFRLESWRDDPRVKKTADSTCCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRH0</accession>
    <name>A0ABY7FRH0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_037032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR23363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="73" mass="8385" checksum="26DE9A178D4A7197" modified="2025-10-08" version="1">MAVCSSYWLNIKRRFRANKDPLKMGNCLKAQSNDDISLLRGNENQESVEQALGPPPPYQAWYLTFNHASNRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRU9</accession>
    <name>A0ABY7FRU9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">COA8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_037543</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COA8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018796">
        <property type="entry name" value="COA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107">
        <property type="entry name" value="APOPTOGENIC PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10231">
        <property type="entry name" value="COA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR23874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="14071" checksum="9F9E9860BA8021E2" modified="2025-10-08" version="1" fragment="single">KTTHLECHPPEDVARDWIGPPDKVSNIRQLKLHKAENETMAQREYREQQEVTRHWHHQFWEKHNKDFFAQKEVFTQQRLAEKAEKGHDEKITPEELSEFYKKFLDENYKAHIQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FS37</accession>
    <name>A0ABY7FS37_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GRM4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_010737</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd06350">
        <property type="entry name" value="PBP1_GPCR_family_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="988"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="8">
        <location>
            <begin position="182"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="8">
        <location>
            <begin position="548"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1131"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1158"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1236"/>
            <end position="1246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR25033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1345" mass="147625" checksum="2CA90920FE086039" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSP1</accession>
    <name>A0ABY7FSP1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007951">
        <property type="entry name" value="KRTAP_PMG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05287">
        <property type="entry name" value="PMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="251" mass="28700" checksum="03C36971C4FD31A3" modified="2025-10-08" version="1">MSSAGTDITEMSPAGADVRKCHPLGQMSQTFHPLGQMSQKCQPLGQISQKCHPLGQMSGNVTRLGICHRKFSRWGRCHRNVTRWGRYHRNVTHWGRYHKNVTCWYIYRRNVPRWEQISQKRFPLGADITEISPTGANITEMSATGTDITEMSPTGTDITEMSPTGTDNTEMSPTGTYNTEMLRLGQISQKCHPLGQISQKCIQLNRNVIFWGRYHRKTTTWDRYHRKHPIGQISQKCRPLGQISQKMSPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUV2</accession>
    <name>A0ABY7FUV2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_010643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR24939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR24939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="144" mass="15818" checksum="16D58662BD65FCE6" modified="2025-10-08" version="1">MYAKDKPERVTENVQFSYNAAVMAVVTCLLLVMCAVVIVCVLVNNQRNAGDVTRTKPMKVRRPRKGILKKKPQHEVKPPDEQPTRTCCGAIATGSSIRPGRAEPQQFGSDASVERPECFPIRRGGGRLPGVPPAPRQGRLEKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVP0</accession>
    <name>A0ABY7FVP0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_010668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR24964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="11"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="479"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR24964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="619" mass="67599" checksum="EA344B54A972ACD2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWE6</accession>
    <name>A0ABY7FWE6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BHMT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_011081</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103:SF18">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hcy-binding" evidence="4">
        <location>
            <begin position="81"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Hcy-binding" evidence="4">
        <location>
            <begin position="139"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR25377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="355" mass="39352" checksum="4EA66B2A44E4CA44" modified="2025-10-08" version="1">MAPCRFRVEENGAGVDKEVINKFDNKDKRIGGTCVYEGLFYGRPGLLERLANGGTLVVAEGYIFEFERRGYLQAGAYVPEVILEHPEIVRQVYEEFVHAGSDVVLALTYYTHREKLRTIGREGDLEAMNRVALQMAREEQIELAVELGADYIVGETFCCYGESMMALRCIQKYGNVPAVITLSLGTGDLMLDGVKVKDTVLALEAAGAAVVGFNCGRGPETMLPFIQDIKPLCKVPFAALPVCYRTTPEQPCFQSLTVPGTNNRAFPLDLCACQTSRQQIDEFAHACRKLGVQYVGLCCGNSAHLTRIVAEVYERTPPASKYTPDMSQHYMFGDKSRFRKEFTEGLRASKGGDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FX73</accession>
    <name>A0ABY7FX73_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HUTU-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_012504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="entry name" value="Urocanase like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="UROCANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216:SF3">
        <property type="entry name" value="UROCANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase Rossmann-like" evidence="2">
        <location>
            <begin position="145"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR26800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="477" mass="53346" checksum="9340A27A4D01A19B" modified="2025-10-08" version="1">MSSLKEICEGIPTNPLPPRREREENVPHAPVRTPGLTRDEERLALRNALRYFPPSVHETLVQEFADELRNYGHIYIAYPIGDYPARCRQAAALMHMIMNNLDPRFLLVMKYLSEMSDEQTLVLYSGHPAGLFPSSPEAPRAIVTNGMIFVTSGLGGMSGAQAKAAVICGCVGVIAEGWLVEVTDDLDVCVSMIRRAKKERRATSIGYHGNVVSLWERLADEFDRTGDLLADLGSDQTSCHNPYLGGYYPVQLTFEEANDMMHENPVKFKNLVQESLRRHIAAVNRLADKGMYFWDYGNAFLLEAGRAVKENVKQQYNDNIRWIKEASKNKMVVGSQARILYADDNGRVAIAVAFNKAVAEGKLRTTMTLAERTAHTEKRQIFTTDQPYMAVQNAIGDSFRGATWVALHNGGGVGWKQKLEPVVCYHGMFLMVARRSWAGNTKAKETVCRIMGENSNMKVTLPNAVENDEILDRALKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FX85</accession>
    <name>A0ABY7FX85_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CCNQ-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_012519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd20534">
        <property type="entry name" value="CYCLIN_CCNM_CCNQ_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20535">
        <property type="entry name" value="CYCLIN_CCNM_CCNQ_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048055">
        <property type="entry name" value="Cyclin-Q_first_cyclin_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048053">
        <property type="entry name" value="Cyclin-Q_second_cyclin_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR26815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="144" mass="17016" checksum="BDD3FC7070B955E6" modified="2025-10-08" version="1" fragment="single">MGDNEGLVHFRVVRFIYEAGMKLRMKTIPLSTTCVLYHRFFRENKLDDFDPYLIAATCLYLAGKVEEEQHISLRDVVNDWFDPVTWSTFPLTRTCWGILRDTYHSPLALRYKPQHIAIAVLYFSILCHGLEVPHNRTADRPWWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FXX0</accession>
    <name>A0ABY7FXX0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP synthase F0 subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12711" checksum="DA2DD7A31D9B7DA6" modified="2025-10-08" version="1">MRCSFLSPWFGLVWSVIWLLFFTTTLLLDVFYSTRKEHRKYWLLYLRNWSYCLMSLTLTCETTVRLLGSISSNRLLKGLDFETINKVLLTTIYVITNSVFVTRIPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G205</accession>
    <name>A0ABY7G205_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">IFT81-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_013964</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the IFT81 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.70">
        <property type="entry name" value="Intraflagellar transport protein 81, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029600">
        <property type="entry name" value="IFT81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041146">
        <property type="entry name" value="IFT81_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043016">
        <property type="entry name" value="IFT81_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15614">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15614:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18383">
        <property type="entry name" value="IFT81_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IFT81 calponin homology" evidence="8">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="118"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR28260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="453" mass="52463" checksum="E47635118405BFD7" modified="2025-10-08" version="1" fragment="single">ELNKDPFNKSYNMISFDSLEPLQLLQVLNDVLGVIDPKTAIRIFSCLRVLKYKPPTESTFRTGLVQGDKPVVYHILDWLLRNIPGLKKRAYLAKYLVKVDVPADIMQEDPMNDLYLQYEELIETFKDLHKQAEGLRNSGYNTGEIRKDISNMEDEKEQLIKRVDRLKRKVEQHPNANTMMNVAKNLRLERDKEKKLAEQRQEQLTLIQHSEQRVKRLQQQLHEQRQAAVGATPEGLLQRLEEETRANSYIVKERLPKDIESRKKTVTDLQRVVAEPAMGQADLEELHNKIGELNSEINQLVEKRMRSGEPMDDKLSLFRQQAAIIAHKKENAAEGLRETRDEYSRFTHEVDDKRELARQASGGGEVLKGDEFKRYVNKLRSKSTIYKKKRQELAELKAEFGVSSKKSHLDHTKGQTLEEISDMVRILTGKIAERKGALAPIIKELRPLRQQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G8W1</accession>
    <name>A0ABY7G8W1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDX58-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_033415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041204">
        <property type="entry name" value="RIG-I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051363">
        <property type="entry name" value="RLR_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074:SF16">
        <property type="entry name" value="ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074">
        <property type="entry name" value="HELICASE WITH DEATH DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18119">
        <property type="entry name" value="RIG-I_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="757" mass="86807" checksum="369750C9420F95D1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G989</accession>
    <name>A0ABY7G989_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ZN566-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_003336</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="519"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="663"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR29768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="740" mass="85881" checksum="345F1E6F0AB8F32F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9L2</accession>
    <name>A0ABY7G9L2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_003607</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR30039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="364"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR30039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="485" mass="54882" checksum="F145BF570B26696A" modified="2025-10-08" version="1" fragment="single">CSLLKTILNGEITVNGTIFGSTAHFSCNTGYERYGPEYMQCSEFGTWIPNETTMCILGLSGSPNISHMHATINTGLRKNGNESEVELYCELENQTSDNYYFTVSWGLSENSIWNEIVLISNPTISCQVTARYNQWSDEGPPIFSNEKFCGIKVHNESLNIYNSEIDTLYIELTVPFKCWMSVPACTIELKIFFNDTTDSCEIPGAARTYLYEANRRRKEDVGELEYVSSQCTLSLHCGITLSEKDVGKLRRFHVVSRPGSVSYPMEVLIPMHLSIDGNFESDGLFQNYTPNTVQDGFCTIDAICYNENDEYGCMRCERMGKKVQWVEINDCIDSINQPAYSEDENARDLLKIVKKKKDESFNLKTDAKVKDEPNTEHMKIDHEQHSNDTTSEPILETPVTTTEQDNDANDIQSEDDQHTNGKQSEPNHDTNGNQSKPDHDTIGIQSAPEQETNDIPPEPKQDPKVVTSTHNHDMNDIESETDNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GC56</accession>
    <name>A0ABY7GC56_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein phosphatase 1 regulatory subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MAR_034562</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">MELC-2E11</strain>
            <tissue evidence="19">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Component of the PNUTS-PP1 complex (also named PTW/PP1 complex), composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA (or PPP1CB or PPP1CC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR32020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="18">
        <location>
            <begin position="47"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="17">
        <location>
            <begin position="779"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="15">
        <location>
            <begin position="779"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="119"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="470"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="731"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="155"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="731"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WAR32020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="818" mass="89019" checksum="3E9FC3BF3B7E53D0" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GCK2</accession>
    <name>A0ABY7GCK2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="134" mass="16408" checksum="B70AB7E685A6D1E1" modified="2025-10-08" version="1">MDVSHCIKRRRNNTLKSGIFKRATRMLKLSNSTTIKWQIFVDCYKLDQHNCLQLHRKLINDHLFSDNRLKMQKNLAKDALQKCYTSKRICFEWRDRTLRKYINTYFIFQNMRQIDNNNDKRLKDIECIADWFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GD10</accession>
    <name>A0ABY7GD10_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_033981</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SEC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 central conserved" evidence="9">
        <location>
            <begin position="908"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="8">
        <location>
            <begin position="1079"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="291"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="574"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="829"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1037"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1319"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1362"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1468"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1591"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="402"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="574"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="649"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="674"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="718"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1362"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1409"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1468"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1531"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1632"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1655"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1704"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1756"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1784"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1803"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1847"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1870"/>
            <end position="1879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR31439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1879" mass="210293" checksum="07DC8510EE4AFA81" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GDS1</accession>
    <name>A0ABY7GDS1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">R1A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_033945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058897">
        <property type="entry name" value="PAPPA_SD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25900">
        <property type="entry name" value="PAPPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pappalysin-1 SD scarf" evidence="2">
        <location>
            <begin position="236"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Pappalysin-1 SD scarf" evidence="2">
        <location>
            <begin position="370"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR31403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="760" mass="86360" checksum="07EF4DB672F3C764" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D7A2</accession>
    <name>A0ABY7D7A2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ93554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="133" mass="14975" checksum="32B34639B0CE128F" modified="2025-10-08" version="1" fragment="single">MPGTRTAYEPGHKEACMNLIERLYYNVNSKIPSNGLTLFLCACLSGDKELIMFMLKRGADVRHTTNVGDTALYLATFGVLSHLEAAKLLEIPMPNPHVWDIVDHHTPPHISLGLQSPQRKHLIESTRRMMSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DA38</accession>
    <name>A0ABY7DA38_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ93662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="230" mass="25653" checksum="6DA86945FC19B56E" modified="2025-10-08" version="1" fragment="single">MSLKFVADSLDDDEGKRTREAIANYHGIVKFEVAYAQSASEEVPTMGWSDIPLQESVSTQRILEDGDRLRVWVRATDVMGNTRADSTFMRIDGSPPFISSENGSEHQVVLNIEGGEFKHASRASFLAFDQQSGVHKIEIKLTVKSPVKDDMVTYRNFTEARRGNDITDPRCIGFDKIGMCLLPKQIVNIDNCWLSVGNMEIESASGELEITAYNQAMLTATTKFDVRFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DG56</accession>
    <name>A0ABY7DG56_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MAR_028656</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">MELC-2E11</strain>
            <tissue evidence="18">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052150">
        <property type="entry name" value="MsrB_Met_sulfoxide_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46755">
        <property type="entry name" value="METHIONINE-R-SULFOXIDE REDUCTASE B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46755:SF5">
        <property type="entry name" value="METHIONINE-R-SULFOXIDE REDUCTASE B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="17">
        <location>
            <begin position="102"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WAQ95966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="243" mass="26620" checksum="4F6321498A19E84E" modified="2025-10-08" version="1">MNRTKPAVQLNSVSRTYCDGRASSSTTKYRLPVTEPVKKRPLERSSIRFSTWAGVKLPVTFTLAILKLTAGELFSSMSVPVDATGSNHCSEWDIILNHDQGNNVKRIKMSFCSWGGGEKYKDHFEKGVYACSNCGTELFHSASKYNHHTPWPAFNATITPDCLSKVPESTNAIKISCAKCGNGLGHEFLGDGPKKGQNHVEITCATGSAVKDSGTEGTVHYRLDDIPAPHLAFLFGLQRALWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DG57</accession>
    <name>A0ABY7DG57_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_028276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ95586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="295" mass="33512" checksum="B56FCB333C0E4E12" modified="2025-10-08" version="1" fragment="single">MSCKENEVKKRMEKIQSGKERLELEINATFDRLKEKLEEMRGNTLQELADAETCFITDTNQAIVTTRSSEKTEALTVTFIELEKKEILNSKESCGRLRFEEYHYYEPINLENQKTEPYGSEDYYEFKAGANTDKDKSTKDGQDGPPPKSETPTPEVTELAKYKSHSYSLSDHSDFQKTPEFVEIILTSHGLVLLDSANGVLVLSDDKNGKIKNVVKVPFTLECITGVSSDRIAVLGKTKAETCIRVYKSSLNGLKEKPKESFKIENKCLWKREEKGKRSDFSPSNLALHGNKLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHI5</accession>
    <name>A0ABY7DHI5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="232" mass="27050" checksum="B79B55DD423452A5" modified="2025-10-08" version="1" fragment="single">MDAPMNDMEHSDQTDSSESNDENEHVNNNQVDESALVVCEDNRYTKPTVVYTGEDAGSKMIECLLNEERQILEILSHIQPMDISKEEREDIISKATYCCICKKAFTLHDRMYNRITMENVRRYKTIEIIHNKKRLDKVTAKPTYKDTTILNEDLVAVELYKSKVNLVKPIFCGMSILDLSKCLMYDFWYNHIKRKYPTSTLLMSDTDSILACYQTEDIYKDMKSSMCHFDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHU6</accession>
    <name>A0ABY7DHU6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="104" mass="11600" checksum="BEEB51BC8DF0E915" modified="2025-10-08" version="1" fragment="single">MGQNDEMQERSPSDDSQQGYQFPNAVLSNTDRQLNGQNDEQQERSPPSDDGQQGYQSPNAVTSNTDTQLNSQNDEMQERSPSDDSQQGYQSPNAVTSNTDRQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJV1</accession>
    <name>A0ABY7DJV1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Y1735-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_022354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="7"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="138"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="408" mass="43671" checksum="78D5BCEF8CBD83D7" modified="2025-10-08" version="1">MLTSLNATTFKGLVDQAGLASVLQGPGPFTLLVPTNAAIAKIPNADLASVTANAHYLNEIIRYHVISDVHESHSFPFGRHLFLNSTNGHVIRVYRSAVALNVPEGTVIDILGNPDYQTSKFLELVRQAKLDTNYANPKYHVHSGTLHSASIVKRHSITTTLPAHSIAVTTNDAGDIILDNTAQITDDDIEAENGVVHNGKVGRVVSGRPGRVGRVVSGRPGRVGRVVSGRPGRAWRVVSVRTGRVRRVVSGRPRRVGRAVSERPGRVARVVSGRPRRVGRVVSERPGRVGRVVSGRPGRVGCGVSVRTGRVGRVVSGRPRRVGRAVSGRPGRVGRVVSGRPRRVGRVVSERPGRVGRVVSGRPGRVGVGMSASSSSTVVDGCRHGRHTNVNPASFFIASRYVAREIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DK80</accession>
    <name>A0ABY7DK80_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPPP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_029701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008907">
        <property type="entry name" value="TPP/p25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12932">
        <property type="entry name" value="P25 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12932:SF9">
        <property type="entry name" value="TUBULIN POLYMERIZATION-PROMOTING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05517">
        <property type="entry name" value="p25-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="216" mass="23623" checksum="A2D706CDF9D345F0" modified="2025-10-08" version="1">MATKGDRKSPEDPADGGAPKTPEGASAVPTSDDVDVDLAAKFSAFCDTKTKDHFTSKACNKLVKDCFEDHFKFKKIILTNRVDSSVFSKCKEKGKPHMLVTSGNCKKFLQHTAHEFAKLKKGDDRLPKEDPAVNDMYTALHQRVIQSSGPKIKAVKQSATGNVQGLTDTRKYTGSHKQRFDESGKGRGKAGREEDKTASGYVASYKGEGTFEEGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKB1</accession>
    <name>A0ABY7DKB1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="151" mass="17194" checksum="9B91EF71AA0D15FD" modified="2025-10-08" version="1">MVDIPGYEWLMLGIAVYECLMVGIAVYEWLLVGIAVYEWLMVDIAAYQFHRLIFCDRFLSQLIQDKPLADCVPCGNYAANLVIQRSGCTVPDKPEFKHCSVCVVYDRHCSVSVVLGIAAYAMFMIDIAAYWWFMVDIAAYAMFMIDIAAYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKH7</accession>
    <name>A0ABY7DKH7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YMD3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_030078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="426"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="464" mass="54238" checksum="147A50D611622364" modified="2025-10-08" version="1">MLRHQNTSIIRRNLSKKIVFNKAYPPPPPPPPPQRATPPPPPPQGATPPPQGATPPPPPPQGTTPPPPPPEENMISPKYDHPFTMMISGPTACGKTTFVTNLLQHHNTRIQPSVHRIVWLFKRWQPLYSIIKNTVLPKVEFVQELIIYSFWTTCFSEVGEDKRITDLFTEDSHNRSLSVVSINQNIFANKRSYTETQLSLSVDRQSLMTLARQMYPGHTDKCMNAFAKATKYPYGYLLVNLKPFTAEDDRLKYDLKLKSKRVQDLMRKFNVHFFPTQNETKASTSERAILTIKQKLYRYFNHKDSYNYISVLQNIADSNNHTYHRTIDMRPADVKENNQEERKKLLPKLKPFKFRVGAYVRISHLKTVFTRAYDQTYSGEIFRVYTRYHRGILPIYRLQDLQGDEIKGTFYESELQNVHVDADQTWKVEKVLKRRGKGRNKQYFVKWKYYLKKFNSWINASDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DKT7</accession>
    <name>A0ABY7DKT7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_029789</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034720">
        <property type="entry name" value="Viral_alk_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF3">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01771">
        <property type="entry name" value="Viral_alk_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ97099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="198" mass="22607" checksum="2499E7B916097F61" modified="2025-10-08" version="1" fragment="single">RHSRASCKCSPDKDLRTVTQESVYWLLPTSLKGVSYYKVRNIDFSAAKTLKNTFFQIYLQQVGNPLYCQFGRNIQMHMYQRLWLQKLLKRCNDINIEVSEEEVSNVEKATKKQSEENLWYDFRAGRITASKIENACHTDPNKFSNLATRWGLSKETVARSTLLNILIGAHENVELEDSGLCISTDCPHVAASPDGIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DL10</accession>
    <name>A0ABY7DL10_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IKBA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_022770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ98397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="315" mass="35351" checksum="4844EACDC119A1FB" modified="2025-10-08" version="1">MAPAGLITLPRDTGMCLPKYHHLNQMFSDMKRQKVDNEQQYKGEQNYDKQQDSMPRLTVATAADSLAEKALIANVIMTADRDGDNFLFVAIIMRKTELAINLINLTTDYSQVRSVNKLRQTALHLAAITNNPKVSRRLVVAGAEIEMQDYNGNTALHIACIQGWAGVARSLIQHVSYEETKQNSFKIPYVPIPQNFEIRNYDGSPCLMIAICKGYLDIADMLIDIDADINTFDMKTGMTCLHAVTELGQIHLVRYLLPKPNLKINAETYSGYTAMEIAFYRGYADVAALLKVSGADRPRPICIIENLDLEEDRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMK1</accession>
    <name>A0ABY7DMK1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AR19A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_023297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ98924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="109" mass="12049" checksum="E077EC5F74FF4EF5" modified="2025-10-08" version="1">METQTQPESVTFKVPEDPASIEKEQEAKLKAKYGPLPKYFDSGDYNMAKAKMNNPKKPLPAREKLMLQESLGAAIPTPGEVEHMRRPSQIASKLLIHDVEGEGDGQIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMU2</accession>
    <name>A0ABY7DMU2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_022222</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="520"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAQ97849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="580" mass="65156" checksum="D9A552B917053E26" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DPF5</accession>
    <name>A0ABY7DPF5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CP2J6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_023126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAQ98753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="137" mass="15590" checksum="719D9ACA3A5CD5C2" modified="2025-10-08" version="1">MQSQVGGEFKHMLPTFYLILKERNHSLKKLFRGVHIKYTRVLLSLVIANAPYELLKKNVFLSSAGFDTTHKKIRWLVLYMAAYPAVQGCVQELIDSVVGQNRPPVLADKPRLVYTEAVIQEVMRIVTMVPLSIPDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTD3</accession>
    <name>A0ABY7DTD3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="716" mass="83007" checksum="FBE3BFD91181FB69" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTJ3</accession>
    <name>A0ABY7DTJ3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024020</name>
        <name evidence="2" type="ORF">MAR_024043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ99647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="228" mass="26888" checksum="BFE96BF44DAD005D" modified="2025-10-08" version="1" fragment="single">EFNQALRSHWERDCNLRFDFMRGCEHFKAWTDRQLQICADSSDLKDYKNNTGQCEIVRRIKVVRHQSPYIRPNILLPSTASGREGFLNKAYARSRRFERDEVRFLTVTTLMAGNYFGVGENLRDTFVLARGKTQCALINVAQFSIMGKSEQLRRLKSKRENSIPSNKTLYEKFQGNRKWYEYRNKLLQEVVARKRRTNTASFDDVPRSEMTRPSIPKDLIYYKHNSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWN7</accession>
    <name>A0ABY7DWN7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_025447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR01075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR01075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="115" mass="13038" checksum="729833A4B2F61022" modified="2025-10-08" version="1">MKLCGRRSYDTVCRRRSYDTVCGWRSHDTVCCWRSYDIYALVCGRRSYDTVCAVRSYDTVCGLRSYDTVCSRRRMPLCVVGGRMTLCVVGGRMTLCVVGGRMTLCVVGGRMTLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXF6</accession>
    <name>A0ABY7DXF6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_025186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045347205" evidence="1">
        <location>
            <begin position="20"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="648" mass="74668" checksum="1BC3490514ABD419" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZ84</accession>
    <name>A0ABY7DZ84_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_009591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046565704" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="20"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR03033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="126" mass="13154" checksum="9678D15E927ACBF8" modified="2025-10-08" version="1">MEKVILSIVVFSAVAGYVRAGNCTVLGNGVFEAGCRSYLVCSGGGSNIVECPAQQVFNNATSNCDDPANVARPCGQMIDCSSQSDGRYADKDNNCLSWYTCTVFDEGLATCNWANAVAPPCGTMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E002</accession>
    <name>A0ABY7E002_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">OCTL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_024878</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="55"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR00506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="540" mass="59396" checksum="5BBAAEFF90422622" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1C1</accession>
    <name>A0ABY7E1C1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SHPK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_008782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd07777">
        <property type="entry name" value="ASKHA_NBD_FGGY_SHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF67">
        <property type="entry name" value="SEDOHEPTULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR02224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="438" mass="48016" checksum="31E6EA2C1399DB5A" modified="2025-10-08" version="1">MAESGELCLGIDCGTTSVKLSLIEKSTKTLVFSTSEVTNAYVPSKIGSLGAEQDVVKIFDAVISCLNRITDEKRSRIKCISVSGQMHGVMLWNSGFTFECKDTSQLPSFVSNLITWEDKRASSQFLATLPEPNSHQPLASGFGLVTLFWLVKNDPEMVVKFDTVGGIMDFFTCMLCGLDKPTLSNQIAASWGYFDCETNTWNTDILQEHNFPVFCLPNVIEAGSRIGDLSYEWFGIPKGTPILAGLDCEGFVPRKPEVPSPVSYFPYFNSTFLAMAASLNGGNNLKAFVKMIQQWFQTFDVVIPEDKIWSKLTELSMVVDIPEYPHNLVIQPHLCGERHAPDLTTSLSGLERSNSSLHSVFQAICKGLVNNLNLMMPVAMLIESGVQRLVLSGSVIHKQPHVTTCVEKIYAPLSVVPGSNDDASFGAALVAAKFLNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3P4</accession>
    <name>A0ABY7E3P4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPRS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_010392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="82"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR03834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="247" mass="28001" checksum="CFEDF530ABB5A532" modified="2025-10-08" version="1">MMRLDSCSSAPSSSESDLHGDSLGDLSDSSVDRERSFLSRLPRRHRRQSATSVSTNPGEDAYVMVLQNRQGLCDDLRSIVTSRDVCDVTFLVGEERKPVHGVRAVIATRSKLLYDLIVSHEKNRNKDSKRHCSRVKRTLYKLNCASSRRHLMKTSRLLNAAYMFGFPELRQACWDFALGCTARADNLSDLLASAKMYHNHKMTILLLKTIKNFTEVFPEIKNQIDVVDNILQNNAETEVIQGILELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E518</accession>
    <name>A0ABY7E518_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_010455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR03897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="520" mass="57299" checksum="BBBAA4507BD620C4" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5J4</accession>
    <name>A0ABY7E5J4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR04073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="186" mass="21101" checksum="2A9E9AC4BA7C2585" modified="2025-10-08" version="1" fragment="single">LAGGVKFIPFPKPRTKLENCLRWIKACGRPHEQLNTNTINGNYHMFVCTEACFNLKNIIDVAIFQIGGLSADFHDPTPADSCAVQQATLARRPPKRRHELEPVPIRRIIFAQIDISNPINDEKHPPTTTYEYVNLNAHPKPSSTETVPNKVSIQLEENSAFCKEHETKDTCSTFRLKTQEWFSENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6A8</accession>
    <name>A0ABY7E6A8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_020939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR05570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="294" mass="32313" checksum="55EE59C0C5D7F561" modified="2025-10-08" version="1">MAAFKEDETITLNALKLLCNLQESDKGCWWIAEESGISVIAMSLRNFPNCSEIMAFGCTCLANLPRRGMNTVALGSAESSLLYLRQQHSLSTEVALALCSFYENALKAGTECGKLVTSVAMETMTQIMQDFEDIEIQVTGCQIMAQVVLVEGMETLEELCCLEVVLECMRTHPCHAHLHGVCLLAIENMCRADSIRGSNIQNVCDAVSKSMKAHGDNNEIQLVQKRKSVDFLGPLVTVTHRKSVTEELLDVASAAIHRLRKFTDVVLDDTVEGDSEASQTESTSENVPIDNDYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E6Y4</accession>
    <name>A0ABY7E6Y4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZN595-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_009464</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR02906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="287" mass="32404" checksum="26DDCDB3385D3649" modified="2025-10-08" version="1">MLDFTPVRDPCSACFSNGISLQQHIKTHTKEKHTFCDPCCAACLRRHFVKIHKPYKFETCSAAFALEANLKNHKGMHTCQSGEEAFVCGTCGVTFTQGSDLQKHADYNHTGEKSFNCEICAATYSQKASLKSRIHIHTVILLMSCSDCTPIIFDIPFRVHSEQPGKNLSVCGAVRGTMPVFHMLSCFYTYNKFTQTHNNTYKGKPYTNVKQASFYKETVPLILTTVCMFIHKQIYSMEKSHVCGICGAAYTLKYNLNRHMAIHTGENPFRCEIFGSSFTKHIITNFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9D4</accession>
    <name>A0ABY7E9D4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35457" checksum="ECB8FE228A64E9B3" modified="2025-10-08" version="1">MHKGRPLVKPMVIVTTSGHYMSVLGPYLSDGKNNDAKILNHIINTNVEDIKSYVHPGDIFVVDRGFRDSLQLLEDLGIQSKMPSFLPKGETQFQTEVANTSRLVTKVPFIGDFVQIICAVCNKYLPPLSSSCSDDDRLAQHMLQLATQENSLKTEIEESNLDKSRAVWVPVSDTDLEDFPRLTEDILRTLTCGVYQLKLCPGYIQEHLEGDEDIRVHKERSGLIRVRLQSRHVSAKQYNLWIKFNNYEILGWYCKCRSGSRIVGMCAHCAAVIWYLGYGKHRFLGALGVRDWSEYVDDASVVPPTVDSSDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EA45</accession>
    <name>A0ABY7EA45_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_020987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR05618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="135" mass="14457" checksum="92E1722B7A9BB8CD" modified="2025-10-08" version="1">MTFEEAERFNRTLALQRYKSLAILMYVLSVGLLVIGVTAVIKYPVSGVGTPYYGGCFIVGCLALIYALVCSYIAFKGADDTNNGTSKKEVVHALGVHSPPPPNYPVGGVYDKSEHPFPSAPPSPSCPPPSYDSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBK8</accession>
    <name>A0ABY7EBK8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tubby-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_017351</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the TUB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018066">
        <property type="entry name" value="Tubby_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005398">
        <property type="entry name" value="Tubby_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF7">
        <property type="entry name" value="PROTEIN KING TUBBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01574">
        <property type="entry name" value="TUBBYPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01200">
        <property type="entry name" value="TUB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01201">
        <property type="entry name" value="TUB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Tubby C-terminal" evidence="8">
        <location>
            <begin position="502"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="106"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR07393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="636" mass="70711" checksum="B99BD9D62A45DE40" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBP0</accession>
    <name>A0ABY7EBP0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="68" mass="7775" checksum="444DCD07A402E48D" modified="2025-10-08" version="1" fragment="single">MLLKKGTDVIDLTSFSLLHHTTKTCNTGFIKLYSMVNQRIYHQVEIYTALDSGNEILSVFCDLYPAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBX5</accession>
    <name>A0ABY7EBX5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="156" mass="17062" checksum="88D7F470B824EBFE" modified="2025-10-08" version="1">MKRLANQSSMMCFGTSFTRVLNLQLSRRSYDSSMGVTLSGNGTSGGFTVQENSPLQLTCSSSTDTQYVTYSRRYTDKSPNIITAVGYGSSGCATDPTPPSYLSCSCVSRREYVCVIRNVTRAMHGDVWFCLPARGIINDANGDKAIVVTKFAKYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJJ0</accession>
    <name>A0ABY7EJJ0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FEM1C-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_035244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL C, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121:SF23">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL C, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="948"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR10168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1165" mass="131879" checksum="76AF0E8CA8CCEDBA" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKF1</accession>
    <name>A0ABY7EKF1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7375" checksum="62B5B373E4437055" modified="2025-10-08" version="1">MKRDSCIITRHECCYCIDRQPKSAASITSDIETSIGLAFDTGITDILITGDLNLDRTKREEIGGANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EKL0</accession>
    <name>A0ABY7EKL0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="205" mass="23854" checksum="3FAAA1136D3E61D1" modified="2025-10-08" version="1" fragment="single">MHCTYFQKYFSDDLSKPNNIAERAKEQVTKLRHNPDMEIGSMDITENEVSTITSYIRSVENHMTELRCNLEKFMIDGDKQRMFVKSQMSVATALDFKEDLEELYMSQYSTLPVYPSLPEIDDKIHDIYVKPKVIQLDKGKYDRALFRGERFRRSMELRKKDVTALKDIFCKGTEQQQNIYIQGEPGVGKTSLCNALANLWSNPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELY5</accession>
    <name>A0ABY7ELY5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TITIN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_036074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056701">
        <property type="entry name" value="DUF7799"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056804">
        <property type="entry name" value="Spectrin_SESTD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25075">
        <property type="entry name" value="DUF7799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24915">
        <property type="entry name" value="Spectrin_SESTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="2378"/>
            <end position="2465"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="2476"/>
            <end position="2564"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="2571"/>
            <end position="2659"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="2712"/>
            <end position="2779"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="2800"/>
            <end position="2883"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="2998"/>
            <end position="3075"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="3083"/>
            <end position="3167"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="3296"/>
            <end position="3384"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="3417"/>
            <end position="3507"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="3629"/>
            <end position="3720"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="3765"/>
            <end position="3852"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="3864"/>
            <end position="3952"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="4762"/>
            <end position="4854"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="4902"/>
            <end position="4990"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="5126"/>
            <end position="5215"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="5228"/>
            <end position="5316"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="5337"/>
            <end position="5422"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="5446"/>
            <end position="5522"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="5545"/>
            <end position="5644"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="5663"/>
            <end position="5753"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="5784"/>
            <end position="5874"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="6213"/>
            <end position="6305"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="6394"/>
            <end position="6485"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="6540"/>
            <end position="6626"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="7827"/>
            <end position="7917"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="9307"/>
            <end position="9395"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="11618"/>
            <end position="11700"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="11770"/>
            <end position="11859"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="12127"/>
            <end position="12217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="730"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="849"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="888"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3191"/>
            <end position="3225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3564"/>
            <end position="3587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="4009"/>
            <end position="4175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="4199"/>
            <end position="4300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="4331"/>
            <end position="4427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="4498"/>
            <end position="4519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="5896"/>
            <end position="6190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="6331"/>
            <end position="6391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="6636"/>
            <end position="6664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="7740"/>
            <end position="7813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="7927"/>
            <end position="7955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="7987"/>
            <end position="8044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="8063"/>
            <end position="8107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="8133"/>
            <end position="8213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="8253"/>
            <end position="8278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="8291"/>
            <end position="8366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="8383"/>
            <end position="8407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="8423"/>
            <end position="8452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="8468"/>
            <end position="8490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="8600"/>
            <end position="8624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="8696"/>
            <end position="8722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="8782"/>
            <end position="8812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="8925"/>
            <end position="8946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="8966"/>
            <end position="8992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="9056"/>
            <end position="9081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="9136"/>
            <end position="9234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="9403"/>
            <end position="9423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="10314"/>
            <end position="10334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="10637"/>
            <end position="10656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="10671"/>
            <end position="10697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="10954"/>
            <end position="10978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="11035"/>
            <end position="11058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="11075"/>
            <end position="11107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="11202"/>
            <end position="11223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="11260"/>
            <end position="11349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="11403"/>
            <end position="11432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="11449"/>
            <end position="11490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="12091"/>
            <end position="12125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="12329"/>
            <end position="12398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="12429"/>
            <end position="12451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13168"/>
            <end position="13192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13542"/>
            <end position="13566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13725"/>
            <end position="13748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13908"/>
            <end position="13944"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1680"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1994"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="750"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="775"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="856"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="895"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="934"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="962"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="998"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1018"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1038"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="4009"/>
            <end position="4023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="4090"/>
            <end position="4108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="4145"/>
            <end position="4154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="4287"/>
            <end position="4299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="4376"/>
            <end position="4389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="5903"/>
            <end position="5916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="5917"/>
            <end position="5928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="5947"/>
            <end position="5964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="5973"/>
            <end position="6014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="6055"/>
            <end position="6074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="6110"/>
            <end position="6125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="6133"/>
            <end position="6151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="6159"/>
            <end position="6190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="6382"/>
            <end position="6391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="6643"/>
            <end position="6664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7748"/>
            <end position="7758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7772"/>
            <end position="7804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="8018"/>
            <end position="8028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8030"/>
            <end position="8044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8087"/>
            <end position="8101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8134"/>
            <end position="8174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8197"/>
            <end position="8213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8253"/>
            <end position="8269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8315"/>
            <end position="8329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8340"/>
            <end position="8356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8387"/>
            <end position="8402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8432"/>
            <end position="8444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8468"/>
            <end position="8485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8600"/>
            <end position="8620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8696"/>
            <end position="8710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8782"/>
            <end position="8800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8925"/>
            <end position="8935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8966"/>
            <end position="8981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="9056"/>
            <end position="9070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="9136"/>
            <end position="9160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="9170"/>
            <end position="9184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="9207"/>
            <end position="9224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10324"/>
            <end position="10334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10637"/>
            <end position="10648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11085"/>
            <end position="11107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="11266"/>
            <end position="11275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11302"/>
            <end position="11316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11403"/>
            <end position="11414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11421"/>
            <end position="11432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="11452"/>
            <end position="11462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11466"/>
            <end position="11487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="12108"/>
            <end position="12120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="12333"/>
            <end position="12353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12357"/>
            <end position="12372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12380"/>
            <end position="12396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13174"/>
            <end position="13192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13544"/>
            <end position="13563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13729"/>
            <end position="13748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13912"/>
            <end position="13931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR10998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="14039" mass="1595221" checksum="61626101CAF9061B" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMD8</accession>
    <name>A0ABY7EMD8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_036234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR11158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR11158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="837" mass="95133" checksum="28D43956DA8F6A2D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EN16</accession>
    <name>A0ABY7EN16_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_025563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="677"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR11383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="731" mass="83665" checksum="FB3AE888BFF104A1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQ64</accession>
    <name>A0ABY7EQ64_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TRI33-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_026273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR12093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="247" mass="27819" checksum="3D8D2EC1EE0F2FE9" modified="2025-10-08" version="1">MASKHTKSFKDSMSMASDLIHDFVCSPCHEDKLNTEAKHFCRDCSKYYCDKCLTFHSKIHKEHTVLGRKDVDKWVGQGDSLISCDLHPQEVIKLLCEDHAEMCCHLCVSLNHRMCRSISLISDLAKGVYKMADFMQLPCKVAKVTTSLNQFFSTDDNSDHTSALTLYRPPPPPPSKTDQQKLLPETQTGLNHCLPIVVYPLSEDLQDSIQRRVPRSFSPRVISLEEVEGLVSSKARILVPSTVLTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EQQ5</accession>
    <name>A0ABY7EQQ5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECI3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="148" mass="16752" checksum="FB7AEF6B3235A4C0" modified="2025-10-08" version="1">MVDTLQVSFEEDGFATIQMMNGENRFQLSIIDEWNRALDKVLENKNTKGLLIKGMGRFFSNGIDLNWLGEQEGDSRRKFMDGLHRMLVRVLVFPVPTAALINGHAFGAGAFLALACDFRLMRPDRGWLCWPETAIGMRFGDNLLKVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERX1</accession>
    <name>A0ABY7ERX1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR09941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR09941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="858" mass="96847" checksum="EFECB98BDDBAAEA6" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETU3</accession>
    <name>A0ABY7ETU3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_026827</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR12647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="29684" checksum="04EAD4422D71514D" modified="2025-10-08" version="1">MHFVGVVLNQNNAIGCPGRLDPFVLHKTSCMVIYFTTFLRMMDTLCNEKVDMEAKGIQQGELELAINTNTGSDSRVSCDFTVTAENGRHVMFYFTDLFLGSPNFTERVDRACIEPRDINGNYETFLAGSCRTTERKCNNERCIAHDIVCNDRNPCGDNSDCPTGLEHLSSWAMSGIVILALLCGGIVIIMATVCLQRAGNKNYDLDDVTIPANGMVHHECPHVEMNEVPNIDKKPHTNLTGAQNDNLSMKVITNCPGLQRRVKMKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETX5</accession>
    <name>A0ABY7ETX5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_026857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR12677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="247" mass="28198" checksum="428708CC10B83C71" modified="2025-10-08" version="1">MKPTFGMEGTKDCGMVIEDPREEKKRPKLAKYLAASLVGLVTVAGIVVLSVYIGTRISKGAYEGALRKYSDGDGRQVEEMITQKQDEVLVDVPNSVHMVYDYKHGLVFRRYTDMNTKKRGPCYAAYIGEMDPKPDTQFAEEGQMPAPTGEPEIKQQWRFTDNKVPSNLASSTNVQNMCQDTDIFWMEKTADTGLEKREDYVLVYIGSVYYDAIYNGVAGRLEARYYDVFNVNGEFQFVYYELWFTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUA5</accession>
    <name>A0ABY7EUA5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_027730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14926" checksum="0BE7E8D6873B6570" modified="2025-10-08" version="1" fragment="single">LFGRNAHVKIEEVLNNYFKELDKVFKAYNLHEGIDYFWNIDETGLQMEHSPRKILCMQGKKTNTVTSINVQAVTIIECGSAAGTHFPPYYKESWEVAEPLQCCSNIRKGMQGSYGTEFGIFVKKANINPMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVX9</accession>
    <name>A0ABY7EVX9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">R1A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_004227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056601">
        <property type="entry name" value="Galaxin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209">
        <property type="entry name" value="AGL056WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209:SF2">
        <property type="entry name" value="FI24008P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24748">
        <property type="entry name" value="Galaxin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047430430" evidence="2">
        <location>
            <begin position="30"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Galaxin-like repeats" evidence="3">
        <location>
            <begin position="350"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR14122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="679" mass="77027" checksum="E188DE4559B7D658" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EX45</accession>
    <name>A0ABY7EX45_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Asteroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="70197" checksum="CD2E5AB7D86B530C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXI6</accession>
    <name>A0ABY7EXI6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">KPCI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_004087</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd06404">
        <property type="entry name" value="PB1_aPKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034877">
        <property type="entry name" value="PB1_aPKC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="9">
        <location>
            <begin position="245"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="8">
        <location>
            <begin position="546"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR13982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="619" mass="71169" checksum="1DFF65FFBC7D9A01" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F0Y5</accession>
    <name>A0ABY7F0Y5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052970">
        <property type="entry name" value="Inner_ear_hair_cell_LOXHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901:SF7">
        <property type="entry name" value="OXYGEN-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901">
        <property type="entry name" value="PROTEIN CBG12474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="2">
        <location>
            <begin position="86"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR14757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="146" mass="16312" checksum="03808037CD264912" modified="2025-10-08" version="1" fragment="single">MPLTFNYRVAKLYDIAKKENEKLPYLCGTLEQLSLCHDGRGHRAGFFVEMVVVTERSEDKSHIRHVFQCGPWLDSHNDNCHMETMLRMIVTVKTSEGKRTATTGKVQITMYGTSGHTAALLFSSLEPGTLAFTSGAKSEFHISTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2F0</accession>
    <name>A0ABY7F2F0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_030957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR16363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25583" checksum="31F8BCACDE3BB264" modified="2025-10-08" version="1" fragment="single">MSDVTTTQYPVLPASVNMDAKQLISCLLCWAAVPLSIRLISGGSVPVIKAACNTGGRITLSGVPLAMTSLRAEQGNTVCTTSRNGNDVIISDCSKDVEILFMYTDGDAGAPFSTINRMGIKCSEIDAAGVSHVVTADYAGRCSEQPTLMESFDNYYLYAANHYRYWTTIHTFQFHGYKYLQIRCDIHICPCSGVGPSSRRRRRRNMPFGKEDRYLQTHDVIEIVGVTSSAPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2Q1</accession>
    <name>A0ABY7F2Q1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_027781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR13601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="139" mass="15582" checksum="F773A9DF641310A2" modified="2025-10-08" version="1">MSTATQVGDFPQTPGELYTRYYKPKSSLKTPVEPGKRKVKKKTAVPKVAFDTASEDETIHTVPVKKSFQNLLPAFSGAVFERPVSKVIEDNSKSVVMATNHNEVFRNPVVERTIGQLKSDREDKTSSKPVSRFKAQRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F3X2</accession>
    <name>A0ABY7F3X2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR16867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR16867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="87" mass="10189" checksum="218578383BF3B712" modified="2025-10-08" version="1">MPYKALSEVRRRPNTEHNDLQNNDIVQDARRDYDIVDTNLREVELDDLRYETLEVSEVYTIDHTSAYSSIPEQEDDIITYENVIGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4N2</accession>
    <name>A0ABY7F4N2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR15769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR15769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="196" mass="23068" checksum="4F4F3E45E59DCC53" modified="2025-10-08" version="1">MTVLECYRNRIFVFVIWLRSCPTCNILASMFGISVPTVGFQIRSLNTIFYHNLKHLIEWRTMANWREIKGTWTNILWLLGLSMEPLMKFTDWKLSHMNNFTPVTAAIIHLYTYKVSVIAPYTAIQLIRKPILEKVKCRKLNRRIRKYRVGVEHDISKVKTYVNVSTLWRHTRKLLSSSVSTCASLVCSRKQLKLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4N3</accession>
    <name>A0ABY7F4N3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ARF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_004381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR14276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="199" mass="22580" checksum="AC8F6686D8ACC9E1" modified="2025-10-08" version="1">MTPTTLPKVTDKMGNLCTKYNEHKDVKLLLLGLDGSGKTTLLYRLKLGEMVTTIPTFGFNMETVNHKNITFITYDIGGSDKMRQQFRHHYPDTDAVVMVIDGADPERLQKLNCDVIEPALHADELAHSIFLFLVNKRDLPNCLSAEEVAAKLNLKALKHCWHILETSVRQGDRLTESMDWLASRLCPSSSFLRRNPRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F6P9</accession>
    <name>A0ABY7F6P9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBP42-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_032457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="256"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR17863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="493" mass="54923" checksum="431AA6FABF381232" modified="2025-10-08" version="1">MGVSLEMYRQRIGRYKNHAKGIIDESDSDISQCDVVEGFHENSEGWTEIIRKKLQVEVPKPCIQEIRGQGDSNMNSIKEKSGLRSIAVDRRRQKAKWRVITMRGSVKSMQKARAMIQAMIADWQQKFNNSSSHETVRKEQLVTKVSGASIKETTSSNSQLATSLSSFELANHKAMDTSNVTTEKSDVTMEASDVTLETYAEVGACAQAPSPTRSPQQSSVTIIGGVAPRPQAPKLSDLGRQRWSETHNTTGSHDPIGLKNKNGQNLCFANAALQCFLHTRILEILEQHQKCSGDVGCCKCQLRLFFESKGNTAEPILTAMKDIWPKYKLGQQEDSHEFILRILEQLAVINGDSSSSSVNGLDKMFHGKLEYLDSCISCELKNSKPEAFSCLSVSVEKDLKLSLRRFLSPEEPDLCCNKCKTDGTMSKKIQLLDIPEMLILHAKRFLPDGGKDRTVMRVPPVLKIQCSNGVELCAGQTDLDSNGYVFFYKKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F739</accession>
    <name>A0ABY7F739_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">UBR5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_031783</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd19675">
        <property type="entry name" value="UBR-box_UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047503">
        <property type="entry name" value="UBR-box_UBR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46276">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46276:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="9">
        <location>
            <begin position="1136"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="10">
        <location>
            <begin position="2703"/>
            <end position="2784"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="2847"/>
            <end position="3142"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="6">
        <location>
            <begin position="1136"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="546"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="982"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1462"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1531"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1738"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1860"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2049"/>
            <end position="2087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2329"/>
            <end position="2358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2375"/>
            <end position="2407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2425"/>
            <end position="2474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2490"/>
            <end position="2510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2691"/>
            <end position="2739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2811"/>
            <end position="2848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="549"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="646"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1008"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1462"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1546"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1860"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2060"/>
            <end position="2081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2329"/>
            <end position="2349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2375"/>
            <end position="2393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2394"/>
            <end position="2407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2432"/>
            <end position="2446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2450"/>
            <end position="2474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2490"/>
            <end position="2503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2691"/>
            <end position="2705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2713"/>
            <end position="2723"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="3111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR17189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="3142" mass="343022" checksum="2D34833B4CA097FF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F802</accession>
    <name>A0ABY7F802_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_032098</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR17504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="65736" checksum="E5CE951216A9EB36" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F941</accession>
    <name>A0ABY7F941_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Shieldin complex subunit 2 first OB fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_031792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049507">
        <property type="entry name" value="SHLD2_OB1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21669">
        <property type="entry name" value="SHLD2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shieldin complex subunit 2 first OB fold" evidence="1">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR17198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="141" mass="15938" checksum="48B0D8914F6223C9" modified="2025-10-08" version="1">MPHQRCRCYFSLQDSVATTVMVNDKEVNVRTITVEDRTGKVKVSLWRNIAAEPVVLGDVVAITNIVVNSKRYNNEESLSSTQFTKIEFRDVYFSYTGAFIVLPVISFHHQELPNLLALDLGGVESSLVTEQMESSLNRTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAB4</accession>
    <name>A0ABY7FAB4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G2E3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_000955</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd15669">
        <property type="entry name" value="ePHD_PHF7_G2E3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051188">
        <property type="entry name" value="PHD-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059102">
        <property type="entry name" value="PHD_PHF7/G2E3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042013">
        <property type="entry name" value="PHF7/G2E3_ePHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12420:SF42">
        <property type="entry name" value="G2_M PHASE-SPECIFIC E3 UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12420">
        <property type="entry name" value="PHD FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26054">
        <property type="entry name" value="PHD_G2E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="24"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="155"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="287"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="741"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="788"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="945"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="754"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="945"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="997"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1015"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR19117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1235" mass="138452" checksum="6E58CC1EA73C19A3" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FAX4</accession>
    <name>A0ABY7FAX4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_001165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR19327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="70" mass="8130" checksum="298E941076BA7C37" modified="2025-10-08" version="1" fragment="single">MNHKPVDQGHLDSTGNVHEQHWPFQEINNIGHSNNIGHSKINNICHSKRSTTLVIPRDQQHWSFQEINNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FF83</accession>
    <name>A0ABY7FF83_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PHD finger protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_001372</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAYP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR19534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd15528">
        <property type="entry name" value="PHD1_PHF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21085">
        <property type="entry name" value="WH_NTD_PHF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038045">
        <property type="entry name" value="PHF10_PHD_finger_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="461"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="214"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="524"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR19534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="606" mass="68661" checksum="6D6C4697AD0172B7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FH33</accession>
    <name>A0ABY7FH33_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="140" mass="15990" checksum="D3D389101B19872F" modified="2025-10-08" version="1">MDTGRMAFICTFLIGIIAKKRYHVTSTVDNSLLVNVVETGLYIAADFWLVDASYFLTVLWDSDRKHVTHTFGRCSRIWNYFKQTYLAISTTWESIAVLSAPVMVFERSLAIFMGLLACWAAAQISKCFMLKLQQEQEGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FI41</accession>
    <name>A0ABY7FI41_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="170" mass="19792" checksum="061D35064B5D9824" modified="2025-10-08" version="1">MNKKVMVGHKHDCYYVPALLFFNFTVPAPRISNYLDYYRQKAKHDLRNKRRKIQQEFEEERSWRRTNLVTFRENPPLRDTETQGQAGLVLHGVNVHRCTSRPIVPGAQVLRRQDKGGSGDQVVSALEVRGCYVGCTRFYSPAYTQQITEKTTYPTYHSHTSHAIVLTKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FIS3</accession>
    <name>A0ABY7FIS3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_015441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR21467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="154" mass="18090" checksum="B06BC1B972645F2F" modified="2025-10-08" version="1">MYIFAWNGEDGIGIKPQAAKQLLPLAEEYEMFKLRRNCENVLHAAYEQLRKDHRLGHIPPEINEEYLIMSDRYRFDRLLNMCIDEHVHCAAPGQTKTIVNADTLSESVKLIILEKKLARLNNALDRERKYKHDMESTLSNISPRTKWSNKFVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FL37</accession>
    <name>A0ABY7FL37_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR22852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="78" mass="8714" checksum="9CC39800D3EA78D9" modified="2025-10-08" version="1">MFGDSCRVFTAGTARVSELEHPSNTSEQHYYIDKGGLKTLDHRKYSTNCTTQLPHVPTCAAPFPLYLPAFWLDVLPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FL44</accession>
    <name>A0ABY7FL44_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOT9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="377" mass="39801" checksum="36CE667B68A1BDF7" modified="2025-10-08" version="1">MDLPVDVLIATFLANVMFGGLVNCVGLVHAVLLERYHEVAALTSWAGALHSALFMLGAPLSSVVIDRFDCRTAMVTSGFLLTAGNLATAFADNIYVAIVTYGIICGLGLTLAMSASYVTIAFHFKEKSTNLAQGVILVGVGFGTLACSFLLQVSRDHYGIAGMFIIMAGISANIVTCGMVCKPNKAEEHAKIGRKLGVKGVNDNENGSNMRGIVSIPSRLLTGVLANFSAVNEVYIYSVTICLLGIATCLYPLMANVYSGHVVYGTLVGMLYGCCHVVVVAINRRFVSTHFISAALGVVHFGNGLGSVLGPIVGGIVLDSGLTYTHSMFIAGASLLISSVFGIILVCLPIKKFPHVPNPTHQSGLMDENTENETPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FL79</accession>
    <name>A0ABY7FL79_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_036566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="138" mass="15502" checksum="49FD14565811D09B" modified="2025-10-08" version="1" fragment="single">MRLFTDGEDGLEPKQRNANLIIQLREKIHTAKQQMMETKEADTLGVNSLSPERAKSSTEGSVGRLLNQADDSKKMRKKKSKSAHGCGMSMRRKLAVGLGWTTPRIQYIDVSLPSLKVKLKSEKPTFNNLHRIRAKVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLC7</accession>
    <name>A0ABY7FLC7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">VMAT2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_015447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF4">
        <property type="entry name" value="PORTABELLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR21473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="89" mass="9556" checksum="8EFF3FC0C8EE0D5E" modified="2025-10-08" version="1" fragment="single">MFGTGVFCWEPARRSRRYSSGGPYRESGMSMLAEYFSEDERRSQAMGLAMGGCALGILVGYPFGGLLYALSGKTLPFVGIALLAFLSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FLE7</accession>
    <name>A0ABY7FLE7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CETN3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_016143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR22169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="135" mass="15793" checksum="3A206F59E31CABC5" modified="2025-10-08" version="1">MSLSLRAEFALDKSKKKKKRELADEQKQEIREAFDLFDTDKDRAIDYHELKVAMRALVTDMMLERDPQEEILKAFKLFDDDSSGKINLRNLRRVARELGENMTDEELRAMIDEFDRDGDGEINENEFLAIMTGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNY5</accession>
    <name>A0ABY7FNY5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR23842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="280" mass="30844" checksum="E79CB77E287B0A4E" modified="2025-10-08" version="1">MNPEISEWLYKKGQSRLDHRRRRTRKQYWSDIEKSPPEFPGLDNNVANNSKSAKQPNGRKKTNFRFPPLASEFQDPRDSNVRVSDHYNACGGEVASGKSAAVDDNLLENQGFPHGHKMGNFIDSEQDDSKGFQDDNSENSVTTGPDFLSVFSGKPEKDMLKVDSSLDEFSSASADNVNKQATSINTHEHSDTDQNNKNSHREVTKTIEKSKETQAKITNPTAAYLNASGGKSEHNFGGSQSVKGTELSRDTGTGARPKTHVAQVPVAGRAAYSFQVDPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQ18</accession>
    <name>A0ABY7FQ18_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDC5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_036477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR22808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="53"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR22808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="277" mass="30763" checksum="FAB298F4929B2245" modified="2025-10-08" version="1" fragment="single">MNSAERSNLAIALGVSVSVVLVIVVLVAIFYWWRRKSHKMTSRNEPEPAVVSTATIEAMGSGLDEPGSGDSDRDSARSDIKLLAEETSSLRVTSVSSLRESHPNRLYEGQVLVGGTFHDCLESKSKEVWRRLMNETEIQKLSCSHSNVVQLLQTYQNRSIFCVAFDVCMRNSLQDYLLAMPSGRKGNRDIVVPLTKICVDIAAALGHLHSLHVLHRQLRLCHVYLTAAGQAKLGDFYWAKMVSGTDTQTLEEFVVEGGKTRLAPETLLNSHYTDKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FQJ8</accession>
    <name>A0ABY7FQJ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_036860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR23191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="92" mass="10489" checksum="157CDFB7D3078908" modified="2025-10-08" version="1">MTETIVIRQTMFTLVNEFGVSQKKVNGVMKSVVQRLPGRHSVGFLVLVSYHFHRHFQSSKITSDNITYSLALSEVVRGDPKTLFETFQDKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FRY7</accession>
    <name>A0ABY7FRY7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BAG2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_038016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037689">
        <property type="entry name" value="BAG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12334">
        <property type="entry name" value="BAG FAMILY MOLECULAR CHAPERONE REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12334:SF6">
        <property type="entry name" value="BAG FAMILY MOLECULAR CHAPERONE REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="229" mass="25359" checksum="A58F0D6BF56A099F" modified="2025-10-08" version="1" fragment="single">MADEEVDTTTNRLHKLLNDVEKRVEDLRDNALAVQREKQSILEMLQDMQDGAFQQRMSEADRDDIEFNTERLILRCLTIEASVTTPRDDSQEQAFIAVAEIVEKLSLNCGEDPHGNIEKLVAYLNASLPEPLSSNIDSRFQSKLLGCTAEDQKGFRKQLQALHKDVKDKISKTVPNCSPNCSVGNTSNHCNRPGSVSCSTGYTGNGYSSDNEKGIGKVDVLEKGSEVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTQ1</accession>
    <name>A0ABY7FTQ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NRG-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_011297</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051622">
        <property type="entry name" value="R-tyr_protein_phosphatases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="82"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="201"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="385"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR25593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="486" mass="55472" checksum="913C94D9854251CC" modified="2025-10-08" version="1">MNLLEHNGPGFKYQVTVRQRGSIAQGTTYNVDNWMNNTLEHMATDPYFPYAVRVQAKNSIGDSTTEAQEKTLYSYEDVPGAIVKNVEVSDISASTVKLTWTWDKIWLEESGAIAQIHGEFRAFKVQFWRVDEKMSTFQEREVSWVEVLPKEVPAGSQSIKSSYIMRNLPQNAAISLQICVTNNFYVGRPSDPITFTTYEGVPGPVNMLEARIRSSNSFTLVWLPPLNEDRNGIIRGYDIAYQTVDGLALGSLHDRSEQINDPNSVSAVLSGLLPNMKYRIHVYARTQFGRGEGSFIEASTTEKAAIGTPKFEIYNVHENSFNVTWVPDAYFGKHIVHYVEYRKEAAARAIGSNYGWFIGILVAGVLLIGAAVWIYLMHRWRKQDPRVQEKPKTPRDAKAKKSEHEKMYRDSDEDFDRKRYKEDQYDDKYDDQGRGATNYDEPDDQSFHDDRKGYGEYNDERSKFDKSGAPVPAPRPLYKPRSVTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUC2</accession>
    <name>A0ABY7FUC2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RAP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_011494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR25790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="231" mass="26163" checksum="99CC4017353AB5E3" modified="2025-10-08" version="1">MLTIDMKQRVEVIYKCDVENTSTHNIHFGNWSSQIIKAENEGTVQFVQGIFVEKYDPTIEDSYRKQVEVDGQQCMLEILDTAGTEQFTAMRDLYMKNGQGFLLVYSITAQSTFNDLQDLREQILRVKDTDEVPMILVGNKCDLEDERVVGKDQGQSLSVQWASAFLETSAKAKINVNEIFNDLVRMINKKEPGNRKRPGSSSSSGCCCGPNQMLCRRKHHLQDVLSGKSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUE7</accession>
    <name>A0ABY7FUE7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SVEP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_038458</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF4">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="67"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR24789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="230" mass="26015" checksum="29A3C77C9EA88CB9" modified="2025-10-08" version="1">MSKRLCSYVRNGYYLSENKPVRADTLLYFKTIIQPYCHTGYLLTRRENLTCQMDGQFSRRNSECRSVTCSSFGELENGILHYSDVSYKYVDRYTYYSVGVKVRASCDSGFQLLHGSKEQTCLENGTWDGVKPVCSKIRCNDTSILSVRFEQSSSVFSFLERGTASYNSSIFYLVNGNLSFICLANGSLSWEVQPPELGDDAALSRSNSCITTVVTDGNYYESVSPYEFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUM7</accession>
    <name>A0ABY7FUM7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_011642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR25938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="139" mass="15353" checksum="D78370A520F71B9B" modified="2025-10-08" version="1">MIVDLPKSLFTTEAAGFLKPEFLCKEDSNNMHLAVGANPIELDYAASTSKSDGWITKLHSTMINGFPVLVAGTGNVAGLKPSIIKYVLDDGKLLRYHSFNVTLTGYKDEVKALYQKNETDHSLFVMTSKGSDLEIRMQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUY8</accession>
    <name>A0ABY7FUY8_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_036675</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX4/VASA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="343"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="508"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="681"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="692"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR23006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="720" mass="74202" checksum="71704717175061DD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVL1</accession>
    <name>A0ABY7FVL1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_011023</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="8">
        <location>
            <begin position="72"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="9">
        <location>
            <begin position="271"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR25319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="474" mass="52374" checksum="E9FB1456A82B725E" modified="2025-10-08" version="1">MDVSSSPASNVPNYAPAWSNLSGQRECISIHVGQAGVQIGNGCWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAVYPAPQVATAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQLVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSVEGEGEEEGEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWE3</accession>
    <name>A0ABY7FWE3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">EBP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MAR_010760</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">MELC-2E11</strain>
            <tissue evidence="16">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF0">
        <property type="entry name" value="3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="7" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="15">
        <location>
            <begin position="27"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WAR25056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="197" mass="22384" checksum="A4CF2CE41B8E1CD9" modified="2025-10-08" version="1">MADGAINHPYFPRDTHLPHYKPNITSIEELLGLFFGLVAVLNVLLWLGTRGRCLGVRVKVCWFVTCGLIHSILEGGETCMVAMESITAWVDGPLCLLTATAFLVPGMSGWRYVLQLAVSICQLYGDTLYFSTEILENFRHSEYGHPLHFWFYFFFLNMIWIVVPSLNIFDAVRKLVAVQRHVDSTNKSSGKPSKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FWY3</accession>
    <name>A0ABY7FWY3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Y1101-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964">
        <property type="entry name" value="ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964:SF113">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="191"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="249" mass="25063" checksum="A5394F80BDA09609" modified="2025-10-08" version="1">MPLVQGFPNVSPTGGTILMPLIQEVPNVSPTGGAILMPLVQEVPNVSPTGGAILMPLVQGVPNVSPTGGAILMPLVQEVPNVSPTGGAILMPLVQEVPNVSPTGGAILMPLVQEVPNVSPTGGAILMPLVQGVPNVSPTGGAILVPLLQGVPNVSPTGGAILLPFIQEVPNVSPTGGAILMPLVQGVANVGGKVKSVGGNPGDVVCRVAKEEGATLIVTGTRGMGKIRRTFLGSISDYIIHHSNVPVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FYW4</accession>
    <name>A0ABY7FYW4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZN862-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF5">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="1">
        <location>
            <begin position="41"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="360" mass="40179" checksum="7C0BD0B113FA5D5B" modified="2025-10-08" version="1" fragment="single">MTLLYWLVKEEIPQHTKFESLVDTIKGMGMDVLNMLTLGGNANYTSNDFVNKTVVLFGNVIFRDIVAEIQQSPFYSVMIDETTDIATHSQLSIYVRYLHQGASKTVFCSLVKVHNGKSDTIRAAVVQFLRDAKLPLNKMCTFGSDGAAAMLGKKNGVAAQLQTMVPHILVNHCVAHRLALASSQAAEKVPYLLKWKANMEQLFRFYHASGVRTASLLEIQTILEEPKVKVTEAKDVRWLSHNKAVKAIRRCLPSLLTSLEHEARERCDAVAQGLAIFMQQYRFVAALMMMSDMLPVLANLSLALQTKDAVYSTVGTLVMGAITTVRSMKEHPELKFRELPVTIGQLSDQPFRFQKPSANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZ42</accession>
    <name>A0ABY7FZ42_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRI33-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_012253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR26549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="286" mass="32807" checksum="1622B97D3C1E0458" modified="2025-10-08" version="1" fragment="single">MAFNFDLCVQQASDLIHDFTCSPCKDDGLNNEAQIFCDECKKYYCNNCEQLHNKLHRTHSMFGRQDVSKWVGYAGLSPIEICDKHGDKKLELLCEDHDELCCHICVPLNHSIKHIPDLAKGLKKQTDFKKLPANVDTITTRLQGITKKRTHNKQSLKDCGKKMLAEIKSLRKKVNEKFDKIEKKTKDILHDLLHETDEFLQENIDKCTQLIDKLSTYLKTIQSQQDDNTSYIAYKKCTDKMREAESLLQELSIKPDTSLTFQADPRIEQFLSGLNILGEITGVPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G027</accession>
    <name>A0ABY7G027_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 SUMO-protein ligase NSE2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E3 SUMO-protein transferase NSE2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Non-structural maintenance of chromosomes element 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_012458</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="14">
        <location>
            <begin position="123"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAR26754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="208" mass="24160" checksum="27EBE0A942A706BE" modified="2025-10-08" version="1">MSEFNLVDDAVKSLNSIEEYFKVGMDMTTEVALDFLENGQGEEKEFRNMATKLIQLDNDIQNIKKAIEEELDDGECMEDVLHAKLAVMKSNEPDFQQHEKLQELNERMFRALHPDETMLGTCEDDDIEMTQEINTKCPYTGMDMVHPVRNKLCGHNYEREGIMQYIKQRKKKAKCPLSGCGNEKPVEESDLVENKELKRYIEKNKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G114</accession>
    <name>A0ABY7G114_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_012883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR27179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046133367" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="103"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR27179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="327" mass="36824" checksum="C303CB8E568929E2" modified="2025-10-08" version="1">MIGYTTALYILAAATFVTAGHDELVQCTPGVYQIIGKADCTGFFMCVFGKKVEMPPCPHRSVFSSKANVCVPKGSMYDDCNKTTEGSGGHMPVLPDLGSLNPEERCKMFGGMFPHPTECQVFYNCSVNYTRIPWFFEQHLVECPYPQLFNTDTKQCDHFENVKCGSRAEIKDGCQYRSRRCLNARCRPCSVDFPSCVGKRDGINVHPVKLWSPFYAERTIKEERCQADENGRTQFFHPERNECVSLDMIPREHGGMMPECGTKVNGLYQDDFGRCDQYFSCQGGKYIGTVKCAVGEVFDGTKAEKTTYTLSNEKLMEMGKETHRQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1N5</accession>
    <name>A0ABY7G1N5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZNFX1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_014067</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="1476"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="1586"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="1642"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1006"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR28363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2053" mass="236652" checksum="F12EFD0C423AD236" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1N8</accession>
    <name>A0ABY7G1N8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_014079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR28375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="233" mass="26867" checksum="E8EAD0D98EA0776E" modified="2025-10-08" version="1" fragment="single">AYREYSARQLTGRYHSTGSSGPELPARQDYGRNNFTASSGYEHQARQDGGMNHSPVYQHPGRNDTGRDLLTGSGRYVQPERQRTGRNELTGRTGYGLAEQRYGHGQSHPYRLSSYEGVMHGHSYNKTRVFCTNCNMDNHATEACRRRFYWGFTDSHTINFASKNINFNEISFCIDLNKVNINEVEQIQDPNEAREVLYKRLNEVLSHHAPLKEKQIKFETQPAWFTDEIRLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G2C4</accession>
    <name>A0ABY7G2C4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TEuncharacterized</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_013166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR27462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="160" mass="18148" checksum="36AB1B9640CB1070" modified="2025-10-08" version="1" fragment="single">VFQHRVNGSVDFYNNFSSYENGFGSLHGEFWLGLRLLNELTSRRNNTLRIDLQAPNGTRAYDVYGGFSVGNGSNYTLLSSINILSPYHDGQAFSTYDHDMDHQSPTNCAYTYHGGWWYNGCYTANLNGRYGVSGFPYYAGMVYQSFTGRLRLTGSKMMFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G337</accession>
    <name>A0ABY7G337_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_013383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR27679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR27679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1865" mass="206216" checksum="9CDA605DB5D7A11D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G390</accession>
    <name>A0ABY7G390_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BACK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="67587" checksum="AF80E0C6C9D2BBC5" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4M3</accession>
    <name>A0ABY7G4M3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein ST7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_011950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ST7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd11557">
        <property type="entry name" value="ST7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007311">
        <property type="entry name" value="ST7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745:SF6">
        <property type="entry name" value="PROTEIN ST7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745">
        <property type="entry name" value="SUPPRESSION OF TUMORIGENICITY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04184">
        <property type="entry name" value="ST7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR26246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="497" mass="56291" checksum="50CD59FDFEBE1158" modified="2025-10-08" version="1">MLNLFLSTMFLNTLTPKFYVALTGTSSLISGLILVSLNHISPLLGGEPVANNDNGNTTITNGTTTNGNSNNNSSNNHGQQSMPECKVWRNPLNLFRGAEYLRFTWKINKDPLTYYDMNLSAQDHQTFFTCDADAGKPEYEIMQTAWRERKPQARIKAANDALEKNPECATALILLAEEDASSILDAEKLFKQAYKYAEVLYKKSQQTMHLGQTQESIHRRDTNVVVYIKRRLAMCARKLGRIMKEFPILTMFNIHENLIEALLELQLYADVQVVLAKYDDISLPKSAAICYTAALLKARAVADKFSPDIASKRGLSTAEMSAVEAIHRAVEFNPHVPKYLLEMKSLVLPPEHILKRGDSEALAYAFFHLQHWKRVDGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPTCTENADRELLPAFHEVSVYPKKELPFFILFTAGLCSFTALLALLTHQYPEPMGIIAKTALTWIYMPVSYILEKLEAILPSNLFQQLSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G4Q9</accession>
    <name>A0ABY7G4Q9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ZNFX1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_014063</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RZ-type" evidence="10">
        <location>
            <begin position="2088"/>
            <end position="2157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="305"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1048"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR28359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2178" mass="250262" checksum="EFDDD486E132C25D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6V6</accession>
    <name>A0ABY7G6V6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_003240</name>
        <name evidence="5" type="ORF">MAR_003292</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ODC antizyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0688">Ribosomal frameshifting</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR29672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR29724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="163" mass="18375" checksum="F150DD6A01BDD14E" modified="2025-10-08" version="1">MLKASQAIVIDENFGPKAREETPSMPALEATNMRQRCGDFERAPCQCQSASNLCFLIHVAENVVVKWETIFVDGRLYVEIPNSILPDGSKESLVTLLEYAEEVLDCNHVILVFKKNRNDRASLIRTFMFLGFQVVCPGNPIVPMVEDLMFLAYTIEPDSDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6Y2</accession>
    <name>A0ABY7G6Y2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_012745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR27041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR27041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="328" mass="37917" checksum="A54D6D9B20520DC8" modified="2025-10-08" version="1">MGRRGWGVGQRECEREKGRKGGGGGTEIEKEVGGKRESERRDTEKGKKRYGQRDREIERERGGSKRGEGRDTEGERERRVRGSTERERERERKRKRMSSDIGKLSHNIQAIMKSVDEESFTNINELREFRTEINQYLDKRENELLAEIDQKKRTSKTLLDELKLKCTNMKSSIEKLKSEIQAQDDNSNQLLIVGKRAIKELAGLQTALEHVSRRSDVPRYKFHRDPATEQLIASEKAIGGLEEGESTSVLVHQQRQQQTTQEQWQQDTMQQHKKHMKAVSQKGESTSAVGHQERQQQKKQQPRQPATMQQQQKHMQGVSQKGLCTTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G7K8</accession>
    <name>A0ABY7G7K8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_032950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR30408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="247" mass="26461" checksum="4C4636B7023FC36A" modified="2025-10-08" version="1">MAERSFLLYQYSVLAIHQVDMFPLSLDVDTPPNSSQTNQLVCSPITDGTTSVYPLLIPLTVGTTSVFTLLIQLDVGTVRVYTLLIPLTVGTASVYTLLIPLTVGTTSVYTLLIPLTVGTASVYTLLIPLTVGTTSVYTLLIQLNVGTASVYTLLIPLTVGTTSVFTFLISLTVGTTSVFTLLISLTAGTTSVYTLLIPLTVGTASVYTLLIPLSRNSECVHVAYTTQRRNNECSKVFLPVTFSMMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9P2</accession>
    <name>A0ABY7G9P2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WHRN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_033174</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd06742">
        <property type="entry name" value="PDZ3_FL-whirlin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051844">
        <property type="entry name" value="USH2_Complex_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116">
        <property type="entry name" value="PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116:SF29">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="307"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR30632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="485" mass="55428" checksum="0F27FEA1248B8C82" modified="2025-10-08" version="1" fragment="single">NSQSASTSRSATVREKTSRVRRHVAEWELEPLHQAIEQIEDDSKFVHQNYQEPNRLRQSSRLKSASTEQLNRPGPNLLKSSLSSRRSLSQETLPVYIDITSELHGTSKASGQSRSNSASQGPRPASSYAHRQRSGSNSSSLRRKYKSVEDIRQPPQRKKTTPYHSLRGKPLDVKNKLSSHSYTHLLDADPNYPDSPRTTVNGNIVFAEVHEQPRTKALKKQPKGSYGRHAVSRSRFKHRQSMYDPHDGDEEDDEEDNFEISSNVGDYSESFISPIDQILDEEDSYSDLEHRHIEESRKKYGNIPLRMVYIYKTKPTLGMAVEGGANTRQPLPRVINLQPGGSAYESGGLKVGHVILEVNGQSLQGLEHVTAAKTIAEAFKDKLEDSIELLPKPLLKLSRTSLKTVLNYFRLSLMQRLKEFIENETEYHFSIILLYYVLLQKHLDWNVDVHVLNFNGNVIVWYVLLQDDVELYVNVQKCKYLKYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAP0</accession>
    <name>A0ABY7GAP0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RDH13-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_034010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR31468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="355" mass="39589" checksum="668E2EF7BF682D33" modified="2025-10-08" version="1">MELLMLFSNSAFVFMESHRIAIACTITAVCAFYAVRRWMRGARCQSKARLDGRTVLITGGNTGVGKETARDLARRGARILIAGRDLKRTNAAADEIRRTTGNDNVIVYNLDLASLKSVRECAKEVLAKEDRLDILINNAGVMITPIHWRTADGFEMQMGTNHLGHFLFTNLLLDLIKRSAPSRIINVSSLGHSCTGELVNRGIHKQTSFHSTDMDLDLDDLNSEKVDTVTAYGRSKLANILFTRELHRRLKGSGVISVSLHPGAVATELYRYTGDHRLPFRLLITVFWALYKHINKTPEEGAQTTLHCALEPEVEQQSGKYFSDCAVKEPSRQAQDDVMASKLWTLSEKLVGLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBT9</accession>
    <name>A0ABY7GBT9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MOXD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_034427</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057626">
        <property type="entry name" value="S-S_Temptin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF23">
        <property type="entry name" value="MOXD1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24784">
        <property type="entry name" value="Temptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Temptin Cys/Cys disulfide" evidence="5">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase N-terminal" evidence="3">
        <location>
            <begin position="141"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase C-terminal" evidence="4">
        <location>
            <begin position="281"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR31885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="529" mass="58994" checksum="F8F158D285BEE46E" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GCH9</accession>
    <name>A0ABY7GCH9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_028789</name>
        <name evidence="2" type="ORF">MAR_034149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ96099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="91" mass="9728" checksum="175129C655710053" modified="2025-10-08" version="1">MTTCDVDQICRVIMKTAFDELARCENGGDSCGTDNSGVCNVCCRGGGCNYGDCHVIRNQLYDQYKNNGVFDLDTLESKSGGTNTTQSPGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GDB9</accession>
    <name>A0ABY7GDB9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IFI44-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_033795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFI44 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241:SF32">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR31253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="417" mass="45672" checksum="505D1E48EE062CB5" modified="2025-10-08" version="1">MAGKLSREQKDQLEDWIGQGPKTFRLLYAITRDGCSAGTFHTKCDKQGPTVTVLYNPSGSVYGGYTSTDWNRNLSGFSSDAAAFLFQLAFSGKTTMAKFCVKDPTQSIFNYPSHGPLFGSNNLFPFYDSVQESKGVFKLNGNNSFSTCYNMDGVPSWAEINNGNLDVNELEVYQLTEGRESDVQLDRSWRTVPDLNDKTLSELTTAIQGQKTPRKAKMAGYRLTLFGLVGSGKSSYCNTIMTAFQGRVSHRAACGKGDTSVTNTFNPEVELSLDDSHFVLRPNLEDKTHCVVFVLDASSLDGVSQAILLTHIELIDPELGGDLSTVFKSAQVAESVKKASDLLGLPRNSIHPVKNYECEVASDEKINCLALLAFQQILYAAEDGVENLLMKRESASNKPGRELVEVCGSECVDESSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GDC5</accession>
    <name>A0ABY7GDC5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_034061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33153">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33153:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="2">
        <location>
            <begin position="291"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR31519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="415" mass="48044" checksum="65D1711234362F5E" modified="2025-10-08" version="1" fragment="single">MKEGEPGPLQALHGQHTVHGNKRSREAISSQEMHSVMKIDCCQRRCCSYFTPEQVEESRTEYWALRQADQRKWLRKTIRDAQGVYKIHGHVICEEGFLVIHKIGKRRFWNLKKGKEAPASEVPRVRRPTEAGVHAAKWLEDYIRFFADRQPDREELHLPACLTKDMLFKSYEDEMKQGKIRPVSRSRFHEIWLQQMPNVKIRKDPDDLPQCQTCATIQTGLMQLPCKQDREKFLNLRSTHLELQARCRKKYYKHIRKAAKDGLEGRHLSLIIDGMDQAKTRLPRFSVYSKADAHLHKMQQHVTGIKVHNTNQTYLMTWTDTLHPDANVTINALVHVLHDISKSTANFIGKQSLWQQTFQNGKPVENYQAQQWNGGDASKTTKPSVAFVNDLPTQQPSLQTATLELVTTLLEATEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D728</accession>
    <name>A0ABY7D728_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YTX2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_005952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ93481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="178" mass="20899" checksum="BCF76E108639D6FC" modified="2025-10-08" version="1">MSVTFCTLNTKRLGNKQKRLQVFKYIKVKSYDVIFLQETHSDASTSQSWKREWDGCSFFSGLKSNKKASHSLPIIYSRLDYFIISEYLRNTIPKCDIKPGYKTDHSTVLLTPNTLEQKRGPGYFKINNNIINHTEYQNQIKTAIMETVQINSNYNPNTLWELIKGTIRNIYIKYFTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D8R8</accession>
    <name>A0ABY7D8R8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="198" mass="22559" checksum="2AE5957CD95057A8" modified="2025-10-08" version="1">MKGVKQVEIEMNKLTSDVFNKQRNEKQLRNIKYNFHKSKKDVSETGNLADQIINVEEMTKSGDFVQSVKHMNALKQPTITLFTDQQITDIKRFCCKGGAVLGMDKTYNLGDFHVTPTVYKDLSVVKRTTQEHPICFGPTYIHTSSTAKTYSSFLHDIAENLAEHEIENLTIGTDEELAMKMQLDAAFPARRMCYAQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D9H7</accession>
    <name>A0ABY7D9H7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">CALRL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_006773</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15041">
        <property type="entry name" value="7tmB1_hormone_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF42">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR SEB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="13">
        <location>
            <begin position="100"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="213"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAQ94302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="469" mass="53475" checksum="8734C49D4E1F2E05" modified="2025-10-08" version="1">MEYTDGICRDRLFELPVNIFNVFSCSMCYKYLFHTRNKLTPQTEKPWMLVPTENGRTHYSDNFSVLADVKDAKYRDVICNSLNRDDCTRWTDCCQAAIRCCQKQLGIPLSNVTSGVFCPRTWDGYSCFDDVLPSTRVQLSCPSYIEHGSTSAYAYKDCSENGTWWVNPVTGSEWTNYTTCVPKQAAEVTVTWDVAVYLDRLQNERTNTVMHRNSAGCKLLYILTRYVSTANFFWMFCEGLYLHRLIVHAFSPPTTLIPYYVFGWVGAWIPSLIYSIVRATKQEYNSSCWVHNIGTYEWLLYTPNLLCIGANVLFLANILNILCSKLQVHPNEPKNYRKALKATFVLVPLFGLQQFLVIYRPPPGTTLSFTYEILQKGATVALIFCFFNGEVYAYMRNCIGSHINIGTSSKHHNRDNSMSSATQVTSYAYVARRNTKCKDNSGKSYMPLTTSSTTKELTSPTHGHVTFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D9T8</accession>
    <name>A0ABY7D9T8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_006524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ94053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="224" mass="23747" checksum="1361DF03E9297574" modified="2025-10-08" version="1">MAKTMRADSPPLQYGKPGGTSVFLPTIFQWLLSRMILQRVLLLCVCSYAALTERDERSVQIVINNNDGSGDSDSDCACEAVDVGEECCGFCEDSNAECRPFRCVDICQCRDGHVFCGCEAGEGSCQPEQGLNGACVCNAQCPLNSICNPSSAPVFGGDCDGDGGNLGAINCPEWPVFKCQRIPGTGPRPKKCLCNGPFGYVDDGTGTGCVCDIANKPNAQCTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DAS8</accession>
    <name>A0ABY7DAS8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ93887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="228" mass="24711" checksum="F5065388A9D60326" modified="2025-10-08" version="1">MEFEDDSRFGADVEPDSDLEDSESDSQLSQWLSELENYAKGKEPPLARTVVTPKMAMDSFRLIIGFTEGTEVNFDAILGELCELESQLVGAASPTHRRGGGAQYGQSHSHLDPRSMDIPTHLNNGHANPHLRRPNTELECFRTHYPGDLGGYSDAMLDIQDTDSAFSESASLPSSESFTSMVTVSSSTEGAGQGDTASTGSGSTLTPNTFHCEARSHRKNFAGAFLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DD69</accession>
    <name>A0ABY7DD69_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046329921" evidence="1">
        <location>
            <begin position="25"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ94665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="76" mass="8682" checksum="D83B1A31069BF506" modified="2025-10-08" version="1">MNSKGVVVLLVCCLLAIQLASVNGICYQYICKRRCDYRAPNYDEYAFRYLWPIACGRRNVIRWGIISDGSRSSGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DDY2</accession>
    <name>A0ABY7DDY2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_028547</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="156"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="337"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="504"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="617"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="651"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="680"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAQ95857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="720" mass="77987" checksum="C11C1B209F34BC7C" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DE27</accession>
    <name>A0ABY7DE27_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">KAPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_028582</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0114">cAMP</keyword>
    <keyword evidence="3" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="8">
        <location>
            <begin position="74"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="8">
        <location>
            <begin position="192"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAQ95892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="316" mass="35311" checksum="A3B19572E0CA3236" modified="2025-10-08" version="1" fragment="single">EQKAKAKSATPPSDEREDEASITPPHPIAKRSRRGAVSAEVYKEEDAAQYVKKVVPKDYKTMAALSKAISKNVLFSHLDDTERSDIFDAMFPVHRHAGEVIILQGDEGDNFYVIDNGEVDVFVNNDHVTTIGEGGSFGELALIYGLPRAATVKAKGDVKLWGIDRDSYRRILMGSTIRKRKMYEEFLAKVSILDSLEPVQFEDGQEIVRQGEPGDDFFIILEGQAAVLQRRSDNEEPVEVGRLGTSDYFGEIALLLNRPRAATVISRGPLKCVKLDRGRFERVLGPCSDILKRNISQYNSYVSLSFRNFITISSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DF33</accession>
    <name>A0ABY7DF33_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Caspase family p20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ95528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="60" mass="7001" checksum="88D84134E90B98DB" modified="2025-10-08" version="1">MDLSSRTVKPKGRWIMPSFVQMTNSFYKHNFKNENCPALKGKPKLFFIQACRECSFKGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFB2</accession>
    <name>A0ABY7DFB2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_028654</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ECSIT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029342">
        <property type="entry name" value="ECIST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010418">
        <property type="entry name" value="ECSIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046448">
        <property type="entry name" value="ECSIT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113">
        <property type="entry name" value="ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113:SF1">
        <property type="entry name" value="EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14784">
        <property type="entry name" value="ECSIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06239">
        <property type="entry name" value="ECSIT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01284">
        <property type="entry name" value="ECSIT_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="ECSIT C-terminal" evidence="12">
        <location>
            <begin position="264"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAQ95964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="416" mass="48760" checksum="CDDCCD85F3B76AB4" modified="2025-10-08" version="1">MMLRKFILRSSGLIIQTVNSAQGNGKILPKQWNNMMTCYLCRTINSSTVQFSNQGHKRKFQEYYTAVLAEVQSNKRLQMLSNNQEMSKDPVLKERAMKKWIFLEAVEVYLAKNEEHRRGHVEFITDALAQMEELGVHRDLSCYKALLKYAMHHYPRQQDIVVELMEQMETNGLMADWDFGDQLIELFGEHGHVYRKFRRSIYWMRKFHHRNPFQLPHELPVNPVELAILALKKMAIDYENEIKVWKVSETEDLKENLFIASAQSPSQCELINLHPVDQLMYVEGGFRVWMREAHQTYFILRADSDPKLFRQPTEEEELDNLFEFETIFDTEKPKALVPRPNIHQQEDGTILAMCITQTGCKDSLISWIRCLQERNPKLAKIQIVFRLATSEDLFLVPTSSETQPVVNISNEENKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFX0</accession>
    <name>A0ABY7DFX0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MTP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_029252</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045811">
        <property type="entry name" value="MTP_lip-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039988">
        <property type="entry name" value="MTTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13024:SF0">
        <property type="entry name" value="MICROSOMAL TRIACYLGLYCEROL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13024">
        <property type="entry name" value="MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN, LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19444">
        <property type="entry name" value="MTP_lip_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vitellogenin" evidence="6">
        <location>
            <begin position="27"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ96562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="845" mass="94253" checksum="7D34490209ED70F1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGB2</accession>
    <name>A0ABY7DGB2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_007599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ95128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ95128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="81" mass="9118" checksum="05063D57A6E57432" modified="2025-10-08" version="1" fragment="single">THYTKQKRGSLYMPSMYRPVPLSMCIQTSAFRDASTAGFVLDQTSATAKDWQAGYVVKQSALTNILLRSDRPLQQTTTLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DHU8</accession>
    <name>A0ABY7DHU8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UN93A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_029951</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF13">
        <property type="entry name" value="PROTEIN UNC-93 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ97261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="517" mass="56278" checksum="BBBCE64510B7263F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DIJ7</accession>
    <name>A0ABY7DIJ7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_030217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="384" mass="42044" checksum="7BB7F4F4E5CE4072" modified="2025-10-08" version="1">MSDADEGEKAGCMKMRIVEYHNHKTLLGPCLISFSLPLLIPGVTLTVVGSVDNDVTFQAFGGWHIAGIVILTIALLLLLCGILLKCCFRPIISADIEKHLTPMHSRVTGSKNLGYEGESVEHLGAVLNNKVGHHDPAGSHRVVSTHDKKEVPNKSKNNSNIGNTDNKTSKPQVPVSSDNQRSRKDDVGTKPYNERAVDVGDELEENKRNRHTKKHRNDHPSTPIGHDGEVTSHPSGIITKVTASITAEAEASAHSSDPAENSSFIPEVKKKKKKKRKKRNSNLSSASVAQSLAEETEGKQTTGSRNELPVLRSPPNVQKQTDGTIEEKSEDALLTETRLKDEISHRSALVNEGESHHHSSHLHVHFPNTPEVTSRSPERDEIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DM61</accession>
    <name>A0ABY7DM61_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_022626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="6">
        <location>
            <begin position="67"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="400"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ98253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="455" mass="52378" checksum="C411C8552EF9B7FC" modified="2025-10-08" version="1">MEHGKTLKEGLKKPYRQNIKMAATDVQRAPAPAVRTSSQTGPRNLNLTGHVGFDSLPDQLVNKSVAQGFCFNILCLGETGLGKSTLMDTLFNTHFDSTPSTHDLPGVKLKANTYELQESNVRLKLRIVDSVGFGDQINKEESWKSIVDYIDNQFEVFLSEELKIKRSLFNYHDSRIHACLYFVAPTGHSCNQTPKKTHYFHYVTVHVHVLMKSDKQLHVPVSQCNDLSGFIGHCRLKALDLVTMKKLDNKINIIPIIAKSDTITKAELQKFKAKIMAELKSNGVNIYSFPTDDQTGHLPFACVGSSDENENHCDFVKLREMLIRTNMEDLRETTHSQHYELYRRHKLENMGFSDNESKSLSETYEQKRQEHITELQKKEEEMRQTFVIKVKEKEAELKEAEKELHSSFDSLKRQHGDQKKKIEDSRKRLEDEMNLFNQRKAQYQAQQSTLGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMF4</accession>
    <name>A0ABY7DMF4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GLRX1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_022716</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="36"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ98343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="141" mass="15405" checksum="A04EBA5678F9F4FB" modified="2025-10-08" version="1">MSAYKDGYQDNANSVAIATGGVKDTVDRIVRGHAAVVFSRPGCPYCLGARNICRKYMKRTIKPEEVCFVDVEGQTDARAYRNYLKLVTGNSVLPAVFVQGSYIGGLEQLTALHRDDRLAEMLRTATQNDPFSGIPSGKTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMG0</accession>
    <name>A0ABY7DMG0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NXPE4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_022248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057106">
        <property type="entry name" value="NXPE4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165">
        <property type="entry name" value="NXPE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165:SF5">
        <property type="entry name" value="NXPE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24536">
        <property type="entry name" value="NXPE4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NXPE C-terminal" evidence="1">
        <location>
            <begin position="219"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="446" mass="50895" checksum="87F4D10A9C5EFF69" modified="2025-10-08" version="1">MLVNNGSHTVKVGDTVTFTVVLCDRQGKRRQRGGDLVRVWLTEPAVGAAVNARVLDNGDGSYTAATTVFWVGRPEIKAAIISPREVIAAVLNRRHICPPVLVNTAIFQHPVDKSIKEETPCNAYPHVTGYDVICNLTEDNFGWHWYCGKPRHDQLQCVDWTAVADRNLWSLGTDINFQSDNRKALCSFHVIATPPCSRSILSHTWKMDSPTGHLYKNTWFSKNCRPWITKHEIRECLRNTNIALIGDSTLRQMFYSIRTLISCKWGSDTFANGGKHRTTSCNDITTNTSLAWIPHGLPFCTGELPRQYLKTFKASVNILRKTDQRNIIVFHIYAHTLNYHSRVFYSILKDLASVIRRIIADNDNTFVVLKGPHAFSFAKSKDHVIWMPDVYASIYTNFINDEFDDIKDRVMFLEALDMTIATEQWHIHSEKNIILQHVLQILEHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMR3</accession>
    <name>A0ABY7DMR3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase</fullName>
            <ecNumber evidence="5">3.5.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peptide:N-glycanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MAR_022192</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">MELC-2E11</strain>
            <tissue evidence="15">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl)asparagine residue in which the glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue.</text>
            <dbReference type="EC" id="3.5.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.52" evidence="5"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1020">
        <property type="entry name" value="Peptide N glycanase, PAW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038680">
        <property type="entry name" value="PAW_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006588">
        <property type="entry name" value="Peptide_N_glycanase_PAW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04721">
        <property type="entry name" value="PAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51398">
        <property type="entry name" value="PAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PAW" evidence="14">
        <location>
            <begin position="756"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="405"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WAQ97819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="1139" mass="128010" checksum="6E19D5FDBD2DCC61" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DN80</accession>
    <name>A0ABY7DN80_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ98814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="148" mass="16926" checksum="71B912065088E747" modified="2025-10-08" version="1" fragment="single">MGTYFSAQTTESTFYTSEQSQVEVLSELEDKLDVWNGKIKALRLKIEHSECIRKFLPSEIRAASEYLRTKLIEVQGVGYHAPQAKSDHENNRPPSVSEPGQEKKNKYNPVQTNSYEELQTCLVNALEHNARLEESNKRLLAQLEDLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNY9</accession>
    <name>A0ABY7DNY9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CNGA3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_023794</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032406">
        <property type="entry name" value="CLZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF11">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16526">
        <property type="entry name" value="CLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="391"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="584"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="610"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAQ99421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="642" mass="74317" checksum="D016697512DFDC81" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DR31</accession>
    <name>A0ABY7DR31_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BBS7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_023424</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056334">
        <property type="entry name" value="BBS7_GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056333">
        <property type="entry name" value="BBS7_pf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056332">
        <property type="entry name" value="Beta-prop_BBS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16074">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16074:SF4">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23360">
        <property type="entry name" value="BBS7_GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23361">
        <property type="entry name" value="BBS7_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23743">
        <property type="entry name" value="Beta-prop_BBS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBS7 beta-propeller" evidence="4">
        <location>
            <begin position="12"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="BBS7 GAE" evidence="2">
        <location>
            <begin position="334"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="BBS7 platform" evidence="3">
        <location>
            <begin position="447"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ99051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="564" mass="63065" checksum="E9B791733CBD85F9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTD1</accession>
    <name>A0ABY7DTD1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EXOC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_024464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="34"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="211"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR00092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="850" mass="96653" checksum="5B34C54DA8429032" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DTL7</accession>
    <name>A0ABY7DTL7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EXOC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_024554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="34"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="211"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR00182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="832" mass="94691" checksum="2D7F2190C8D1FB7F" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVC4</accession>
    <name>A0ABY7DVC4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="138" mass="14896" checksum="0152069B56513B32" modified="2025-10-08" version="1">MCTEKDRAVPPAVGCPSTTHVRMSPTSTTISIVAANSGVQDMRLRTFSGFGLSRRTLLDCPSQSGVASGAPSAPVRDTKWKSSVVNLVVDRSCPGPAEMVQSSFNPLFQGWCPALNIVRLRRESPLIIVDIAVFRSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DVL1</accession>
    <name>A0ABY7DVL1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_008058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF3">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="191"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR01500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="523" mass="59817" checksum="A2F7EDA389F1FC0D" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DX88</accession>
    <name>A0ABY7DX88_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">IFT22-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_008643</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mab-21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046903">
        <property type="entry name" value="Mab-21-like_nuc_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF42">
        <property type="entry name" value="CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03281">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mab-21-like nucleotidyltransferase" evidence="9">
        <location>
            <begin position="287"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="10">
        <location>
            <begin position="369"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR02085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="561" mass="65313" checksum="EB3EE790B127DEAD" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DXP9</accession>
    <name>A0ABY7DXP9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_024083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="88" mass="10235" checksum="5984ABBF89F45E8B" modified="2025-10-08" version="1">MEIGNIVIICMAVMFQDVYCCYSETTLGRRECCNDRTKSLYNADMTYWNEAFIMSYPFLVLFGGCVTLVIVYTSMQPKEAEVKHEIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZH0</accession>
    <name>A0ABY7DZH0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FBP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_008735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF40">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="104"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="146"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="188"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="230"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="272"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="8">
        <location>
            <begin position="410"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR02177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="518" mass="57006" checksum="6DC37BB47337FA91" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E130</accession>
    <name>A0ABY7E130_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR03693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="487" mass="52777" checksum="E1FA17B84D99FF35" modified="2025-10-08" version="1" fragment="single">MSAFDDLLLDLGGPTQGTQGGSGDPFDPLGSGQMSGSGDLLGLGMEGSVSTQNGDSAKVNFEANTNPLYEFTRSENMSGESSDPLLDFGTEAPAPQKEVKQEPTNPLYDLMGSGDMGEQTNGPMDDLLVNGVSEPVQNGDHGDQVEQEVDLLGTGDSWTQGEQTGDLLGDMGPATSDDSGVTIDTPAVEEEQREETLPVTEEEPDMSQADTENREEDVATAPEVTEDNSLRVETDNKEEDGLDNNDKEGANDTDQGNVTEPEKTQDEQLNEQEGSTSQQVDDNTEVEQPIIEADTDPVEEDMQAKDTDVVETLPEAPIEETVETTPASCEDVMETTPDAPTEIVTETAPPAVVEEVVEEEQEEEEEKQEEPDVIKEVVPVEQQEEPEQPDLTDSKVSQMIEEPEPETVIAEEAPVEPEVEKVEEQEVPVQESTKIAAEMLQEEPETVTYKSTSFLVLSPTEPSVTFSGATREEPETRMSEVQAETQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E167</accession>
    <name>A0ABY7E167_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_009253</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="6">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0801">TPQ</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="9">
        <location>
            <begin position="390"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR02695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="840" mass="95328" checksum="95D1B2D1BF71ABBF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E1D0</accession>
    <name>A0ABY7E1D0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S13A2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_009542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR02984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="267" mass="29174" checksum="E490755249669C63" modified="2025-10-08" version="1">MAVLTFLKSALSLKALWLTPLAFIIPCYLLVYESDGQDPEQATEQQARCAYVIVVMAILWLTEAIPIPVTALMPIFLFPLTKTLPAKTISEYYVTDTTMLFLGGLIIAVALEETGLHTRISLGVLRIIGAQPIIMMLGMMGTTWFLSMWISNTAATAMMIPIITAVVGAVREARITSSKKDGNTQEAAEMNRFAKGLALCVAYGANIGGIATLTGTPPNLVLKDVADKMAESLVLIVFLLLVILWLFRSPPNIDGWGILWMYEETKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E267</accession>
    <name>A0ABY7E267_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="2">2.5.1.61</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_019471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="2"/>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd13645">
        <property type="entry name" value="PBP2_HuPBGD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="6">
        <location>
            <begin position="232"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR04102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="361" mass="39523" checksum="FDF6797A774136AB" modified="2025-10-08" version="1">MEGTKTVVKVGSRKSQLALIQTNTIIAKLKEIHSNYEFEVVSMTTTGDKILDSALSKIGAKDLFTRELELALEKGDVDFVVHSLKDLPTRIVDSLVIGCVYKRDSEYDAVVMHPKHKGKKLDDLDENSVIGTSSLRRAAQLARRFPTFKFENIRGNLNTRLKKLDEDNKYDAIILAEAGLVRMGWNDRIAQVLTPSECMYAVSQGAMAVECRAGDEKTLALLSPIHDQDTALQCIAERAFLKQLEGGCSVPVCVCSTLTDSQISLKGGVYSIDGKQSVIDTVTKTFPEEPAAKKKATNGHTFSAIVHGNIELVLCQTAEAAGMELANRLLVTEAADILAEAKRQTAEAVIAEQKRKEQEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2E2</accession>
    <name>A0ABY7E2E2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GRM3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_009942</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd13953">
        <property type="entry name" value="7tm_classC_mGluR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047273391" evidence="8">
        <location>
            <begin position="22"/>
            <end position="2837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2531"/>
            <end position="2554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2566"/>
            <end position="2587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2599"/>
            <end position="2620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2640"/>
            <end position="2663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2692"/>
            <end position="2712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2724"/>
            <end position="2746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2752"/>
            <end position="2770"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="9">
        <location>
            <begin position="2529"/>
            <end position="2778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR03384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2837" mass="318245" checksum="5E46F258B5378945" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2I4</accession>
    <name>A0ABY7E2I4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_007934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1738"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1992"/>
            <end position="2015"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="2022"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="2089"/>
            <end position="2112"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="2118"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="2730"/>
            <end position="2754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="966"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1259"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1306"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1499"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1776"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1948"/>
            <end position="1978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2171"/>
            <end position="2219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2366"/>
            <end position="2398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2411"/>
            <end position="2449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2522"/>
            <end position="2581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="966"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1313"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1509"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1594"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1710"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1777"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1955"/>
            <end position="1978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2178"/>
            <end position="2200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2201"/>
            <end position="2216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2369"/>
            <end position="2390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2420"/>
            <end position="2437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2439"/>
            <end position="2449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2529"/>
            <end position="2544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2563"/>
            <end position="2573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR01376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2782" mass="309070" checksum="ED236E4F5E2F0387" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2V0</accession>
    <name>A0ABY7E2V0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MLRP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_009671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045386812" evidence="4">
        <location>
            <begin position="21"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="28"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="84"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="5">
        <location>
            <begin position="146"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR03113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="364" mass="41284" checksum="A591FB1E5516AB5E" modified="2025-10-08" version="1" fragment="single">MDGICIVNAVLLVMVMLIDADIREPRDVTCPTMFDDFPGKVKYRRRGSRVVFKCPKKMRLHGKKRLDCQPDGTWDSEPPMCITSGCVPFDTSSHVHLHTRDRYSDGSLMIFSCTGNYQLVGTMEAFCNGHDWSATLPQCLSPKELVECDFESDLCGWSQDDGEEREWVRMMGPTQTGGTGPTYDHTYMEHKSGHYMYFEASNPTMEGDRARLISPTYPPAFSGKCFDLWYHMQGPDDIGHVGSLSVYVKGVSEDLDGLDPAFYIDGNQGDRWHRADLQLDDKHEDFQIVIEATKKLTYCGYPNHTIRITPCFNFTAYINNYDSAKTNNRRHKGSQSKGNKNDGENANRHSDVIKADDCFIDKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E3P9</accession>
    <name>A0ABY7E3P9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MPEG1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_008324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd22579">
        <property type="entry name" value="MPEG1_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039707">
        <property type="entry name" value="MPEG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31463">
        <property type="entry name" value="MACROPHAGE-EXPRESSED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31463:SF1">
        <property type="entry name" value="MACROPHAGE-EXPRESSED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00457">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="801"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="2">
        <location>
            <begin position="133"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR01766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="864" mass="95729" checksum="8BFBB3DAC6F095C8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5J7</accession>
    <name>A0ABY7E5J7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="151" mass="16773" checksum="6B812FC443575C20" modified="2025-10-08" version="1" fragment="single">WLVVKVVKVGACRYIAGTAPISGCFALRRTSPDLKGHGKIKEYGRSKGKVQNKYFRGETPSTSTLLSAEEAYESVYDTIKNVQKIRVQQLSLSTFNMDTNNANPVSGIQNNNHDVCNFDGINTIKKNAVSFIEQNDTVTQNTETSKTRHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E858</accession>
    <name>A0ABY7E858_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_021612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="137" mass="15025" checksum="ECBA10CBEE8C35B3" modified="2025-10-08" version="1">MYVPTGDISRKVNNSDTDALYAQPNKSKASGSEDAELYAGVNKVAKKKAAGKKHKKSTYENKAFENSTYENHELQETKVNKDGLIYADLSFPKLPKGQKPLIHGLDDITVYADVDLSRKADPLPDSDDHGSGGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E8X4</accession>
    <name>A0ABY7E8X4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="270" mass="31622" checksum="A66A65C758D1B842" modified="2025-10-08" version="1" fragment="single">MAFSDNYCYGTAVDSPASFESMRTKDEIGKIVFTVSKEKSTVTIQKHLVRVFKRELGNFMDHLHLQYPDTKHLNFTHVFFTPGKEWIGINVSGLEKSKEEFQKKHDSPNSVTKCLNTYFRDRRIREQCGLEKDSGLDFTFYILNKQISPTPRFPIAKSNDNTELYDVLFAFNVPTNVDLDKILIRSSETELIDGHMHRKRMWCITFAFTKPEIDEVHGKRYYYELHETKRFFSKTNVETTDHDTFKVESSVVHRDCYVDNDTLIAEQLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAH3</accession>
    <name>A0ABY7EAH3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RBBP9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_021533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010662">
        <property type="entry name" value="RBBP9/YdeN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15394">
        <property type="entry name" value="SERINE HYDROLASE RBBP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15394:SF3">
        <property type="entry name" value="SERINE HYDROLASE RBBP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06821">
        <property type="entry name" value="Ser_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR06164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="183" mass="20825" checksum="DFD0D6B819E2DCDB" modified="2025-10-08" version="1">MTHIVIIPGNGGGDVTRANWYGWAQRKLNELDGVKCDLRNMPDPVIARESIWIPFMRDEMGCGEETIIVGHSSGAEAAMRFAEKYKVKGIVIVSACFSDLGDENERASGYYSRPWEWPRIRENAPWRVQFGSTDDPFISWSEQQQVADGLESDLHKFQDKGHFMNTCFPQLIDVIKKKLKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EB86</accession>
    <name>A0ABY7EB86_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FUCL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_021295</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fucolectin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051941">
        <property type="entry name" value="BG_Antigen-Binding_Lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713:SF15">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713">
        <property type="entry name" value="FTP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR05926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="204" mass="22570" checksum="CC6FEC882DBC126D" modified="2025-10-08" version="1" fragment="single">TYNVAFGKTASQSSNFNTSKYLAPTAVDGNVGNNAMASGSCFHTTREYQPWWRVDLLQDYYITTERARNIKLTIGKSLDSMSQAGYLDGGLTTTHTFTVDPPLAGRFVQMQLQGITECFHLCEVEVMAYPSGTRARNITLTIGKSLDSMSKAGYLDGGLTTHTFTVDPSLVGRFVQLQLKEITEFFHLCEVEVMAYPSGEYITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECM8</accession>
    <name>A0ABY7ECM8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="364" mass="40992" checksum="5742EEAA595C67E0" modified="2025-10-08" version="1">MQEMMQNFAHLKSDVDRLRKQMQEPCDESEDESSSMPTPDVADQASCSQPVTATGIFEDIAAALSLSEAKGSPLSGPLASLTDKIIDKTMEDKKRNDLADKYPVPENVTKLNHPKVNPEIWRIIEAKTRSKDVKLLKIQQFTLRAMVPIMQVIDSLVAGRDCQESLNFDELVTKLVDAVALTAVGNADANACRRESIKRDLNEEYQAICSNTNPVTQMLFGDNITDQLKSITESNKIGFKVLAGKFRQTPYAKDRTFRKSGSFFGQRPYPPRYPQTQRGRGYPRGGPHRGQSSRLKHFGTQWEQLTTDKSFLETVYACTIEFIDTPNQTHVRETKLNSKETIVLDREIKGLLFQGVIETTEHCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EE59</accession>
    <name>A0ABY7EE59_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="162" mass="18182" checksum="38554922D09BD075" modified="2025-10-08" version="1">MVPGVCFERLRVEGQQMATPTPRSTRLTKKTCGYNPRAGREAPEIRREKAVLERRAELKREREERLKKKHDLAENNVQGLKISRVHRRQKGAKEKNNGVPGAVPDHEDDCPKAPTSNAAVVTSATASASSSSLKTVSVYSSSGEEESWEAWEERMEDELFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEH8</accession>
    <name>A0ABY7EEH8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLAC8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cornifelin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="116" mass="12569" checksum="70745B264B49FB96" modified="2025-10-08" version="1">MTTVVVTEQPGARQMLIGSVQGHRDWDSGLFSCFSDCKSLLMTYFCLPCAICNISTRAGECMCMAWCVTGGLIALRARIRTLGGIQGSICNDCMAMSFCGMCGICQMQRELEAMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEK6</accession>
    <name>A0ABY7EEK6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">M3K4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_017224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045801">
        <property type="entry name" value="MEKK4_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19431">
        <property type="entry name" value="MEKK4_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitogen-activated protein kinase kinase kinase N-terminal" evidence="2">
        <location>
            <begin position="123"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Mitogen-activated protein kinase kinase kinase N-terminal" evidence="2">
        <location>
            <begin position="575"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR07266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="865" mass="98910" checksum="134319FDD30767FC" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEY3</accession>
    <name>A0ABY7EEY3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_018543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR08585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="119" mass="13769" checksum="D5F11C25153B36E7" modified="2025-10-08" version="1">MPNNTRFKTRPSFKIAIEGQPDLETTNFMTNQKRLQTSSRQRQSEFSKLSRFDTDSDSSTENEPEIRMQRSRRRLQGGTRHSFTNLPSDQMFSDLPMPLYSSDVQGCLPGSVEDVKQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEZ4</accession>
    <name>A0ABY7EEZ4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PALY-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="262" mass="28573" checksum="73A2E076EBFAE448" modified="2025-10-08" version="1">MAARVKCTGNTRPIPAFTCRIKAVCTSSNLHDLTSALPPKPVFIPYTISPSSNFSLSVLGQNDLDPAVGTKAENLGSHWPSYQDISLTVLATTLHESDGYIRKSNQTRLFLRTGDGRDDTERAVRNGPSPRLLSMPVGVSLLGVCGKLLLAQFQEVVNVKLNFGLPPNLSECDINLDFGFKGCDTAMASYMSELDHFVNPMTNHVVSAETHNQSVNSMALVNARLTAEAIEIVQMMVTNLLCLTTQAVDFRLLRNFAIEEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EFD1</accession>
    <name>A0ABY7EFD1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">KRUP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_017580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF104">
        <property type="entry name" value="AT-RICH BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR07622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="362" mass="40528" checksum="00D9F4B2C2BB29EB" modified="2025-10-08" version="1">MCKEWYVIDLSSSKKDGGGGGGGGGGWASLCGGGGGGGGGGCVSLGGGGGGGDMAYQREVCGISFSKLSLLMQHRRAEKHWPKFTCPSCKKNFTRKNNLKQHMKKHDDENNHHCPDCLRVFTRKDALDEHFKQHENQSGGGRKRTRDDGDDADSNTTNKKQRLTTKDDARDYYHVDKISERRIEKFNSTASYYKISVKDMEIRELPNIIKTLKQIFQSIIDNIAGNIPSSDKVRITMDNPQLDFPIVLPFMRRSELTVDRLLSEIERVLQSYEQFILDETFGLEFVHVHMPTGSGTRGKAFVDISKLLNNKGSVIRIKNADELCCARALVTAIARIEKHPLWENIRKGHHAQKQLAINLHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGA1</accession>
    <name>A0ABY7EGA1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="782" mass="84869" checksum="13FCC60CF793B975" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGU1</accession>
    <name>A0ABY7EGU1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="89"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="184" mass="20750" checksum="081022612D02F5CF" modified="2025-10-08" version="1" fragment="single">VYDRLQPLGISLSHSGMLETIFNTELINSIQEGKKFRIVGDNINFNIGVTNERKSTGKTGHMEHWFGSAAIVQNVSFNDCLEPLKMKLKNTVIPLQIQHKNEQKYADVVDILDTYQDLGETLYQGSGLQVPQIHIGGDQLTRERFSDAKRLRAAALTASERFENLSPTTFELFPSSNDYFSNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EH49</accession>
    <name>A0ABY7EH49_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="195"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="540" mass="59524" checksum="56AB549BD5E61C91" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EJ35</accession>
    <name>A0ABY7EJ35_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_035084</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
            <location evidence="1 10">Extracellular space</location>
            <location evidence="1 10">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd19338">
        <property type="entry name" value="Wnt_Wnt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009143">
        <property type="entry name" value="Wnt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF72">
        <property type="entry name" value="PROTEIN WNT-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 10" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR10008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="343" mass="39390" checksum="49C7545F347A9D2C" modified="2025-10-08" version="1">MNIQAFYAFLYFYLMCPADIIGLWWAVGSPLVLEPNKICRKNRKLSGKQRYICRREKEIVEEAVNGARLAIAECQYQFQTRRWNCTTARKSFARILRRDTRETAFVYAITAAGVVYTVTRACSRGSLLQCTCDNNVRDITSDGEWEWGGCHDDVDFGYMKSKEFMDDRRKKKKGDLRTKIRLHNNEAGRLAIREYMTRDCKCHGLSGTCALRTCWRRMPNFRDTGTRLKDKFDGASKVTISNDGRSLVTEDDTIKPPSKEDLLYTEQSPNFCKPRKRYGSLGTQGRQCVPDSMGLEGCTLMCCGRGYTQTQVTVQENCKCQFIWCCQVICKTCTSIKTITRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELF6</accession>
    <name>A0ABY7ELF6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="149" mass="16348" checksum="7A7E21C0FE96E1E3" modified="2025-10-08" version="1" fragment="single">SHDQLFIDTPGSNDQLLIDTPGSHDQLFIDIPGSHDQLFIDIPGSHDQLFIDTPGSHYHLFKDTPGSHDHLFIDTPGSHGHLFIDTPGSHGHLFIDTPCSHDHLFIDTPCSHGHLFIDTPGSHGHLFIDTPGSHGHLFIDTPGSHGHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EPN9</accession>
    <name>A0ABY7EPN9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SEM5B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_035990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038877">
        <property type="entry name" value="THSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311">
        <property type="entry name" value="THROMBOSPONDIN TYPE I DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311:SF3">
        <property type="entry name" value="THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR10914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="189" mass="20875" checksum="CF229DFE919292E4" modified="2025-10-08" version="1" fragment="single">DGDWATWGAWSGCDVTCESGTQVRIRTCTNPEPANGGVNCVGDSTQHKQCTKQLCPGMSATSVHMLSYALNLFFCKINRTVLYTRQCISIQKIKYEKMYQMMITKIVVQFVFMADGVDGQAGVLARLRVTSVCPREGGPVPTQNPAEQGTTVRICHSNSRYALQVHAQVITEGHCYTKSVQYNTFLPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ER96</accession>
    <name>A0ABY7ER96_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BGBP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_026697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR12517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="211" mass="23703" checksum="F92A11EEF9203806" modified="2025-10-08" version="1">MDVAKMWGYCTNADRYGCVRHGRDGLLPPVMSGKLKSKKTVTFGEVFARDGAGHDHGRNQIGSTMHWGPDAGQNKFYLTHGDRDDSTYSTQMHTYCVDWTQDHITVSVDGHQVMTTGGNFWQKGGFSGGNIWSSGSNMAPFDQPFYLILNVAIGGTNGFFPDNWSYNTPKPWNNNSPAEGADFWNARHNWQPSWQGDNVAMEIDYIEMNQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ERQ3</accession>
    <name>A0ABY7ERQ3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxynucleoside triphosphate triphosphohydrolase SAMHD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MAR_026002</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">MELC-2E11</strain>
            <tissue evidence="19">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:46149"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dATP + H2O = 2'-deoxyadenosine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17256"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:61404"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:67649"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dCTP + H2O = 2'-deoxycytidine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80083"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:80084"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>dGTP + H2O = 2'-deoxyguanosine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17172"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:61429"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:15194"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>dTTP + H2O = thymidine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80079"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:80080"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAMHD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR11822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="17">
        <location>
            <begin position="32"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="18">
        <location>
            <begin position="151"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WAR11822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="472" mass="54891" checksum="25438E8D3C22FACF" modified="2025-10-08" version="1">MDMDVISSQESVGEPPRKKTRLDDDYLNYSKWDAETVAEKLKQNGLDEAAERFRENGITGDTLIQLKDKDFEKLEVTDLNQIVKLRKFIRTVKTPPFHFLGQKVFNDPIHGHIELHPLCVKILDTPEFQRLRFIKQLGTCYFVYPGAAHNRFEHSLGVCHLAGQLLRAIRQRQPELDITDVDVLCVEIAGLCHDLGHGPFSHLFDGAFIPIVSPGSSWKHEDTSIKMFRYLVRKNQLDAAFEKYDLTAADITFIEEMMAGPKHYCEDIWALKGRTEDKSFLYEIVANKRNGIDVDKWDYFARDCLMLGIRNNFDYTRFIHFARVLEVNGAYQICTRDKDSETLYDMFHIRQTLHRIAYSHKTSNIIQKMVTDAFVKANDHIKFVGEKGVWKKMSEAIDDMKAFSQMTDHVFNLILNSTDPNLKESRDILTNVLKRKLYKCVGQTQAKGEHMKKEVLYMLYFIVQLVCLFYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ETU1</accession>
    <name>A0ABY7ETU1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G2E3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_026522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR12342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="3">
        <location>
            <begin position="41"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR12342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="354" mass="39349" checksum="7766974458A3EAAC" modified="2025-10-08" version="1" fragment="single">TLDAELDAIAAKVGDCNENWLINVVRRNFFKTTFEELSDALTIDWEKPMKIHFIGEEGLDAGGLTRAFFSLLFRNNDLFENGSFRLDSGLLEKKTYETMGRATVRAILAGHPGPKCFNPLLARFICTGEEPDLADIPDEYVGRPDVLAAIQEISTDSTGSGDLVQRHGDLLEQAGFRKVLSSSTTSEAVHALKRHFTFYHVIGPLLQFRQGMGLKLLGVQTAIQGHVEESIKFFTTSPVSASDVQSFFKPTYTPNSELKPREEMIMYNFGKFLKKAEPVINTGHVLQALIGCETLPRNIECGLVEFSHTSNNLTTVNTCAPSIMFSQTAHIQEYETFEKHFLSLIVDAVGFGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUN5</accession>
    <name>A0ABY7EUN5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="6">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_027740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP111019">
        <property type="protein sequence ID" value="WAR13560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR13560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="384" mass="44129" checksum="B7DC58F4C050A1B4" modified="2025-10-08" version="1">MWSNGPKECHEIPDYTFDDHFRCPVPSFLPRAALREYLEGRWTKGEEDLRKYIKFNTVVRNVVYNDASQNFTVVSTDMKAGVSSTEVFSHVIVAVGIFNAPNKPPFDGIEKFEGRIMHSHDFRDAKEFKGQRVLAVGAGYSAEDIALQCIKFGAKSVICTWRTKPMGFKWPKGIEERPLLQRLDCETAYFKDGSSAKVDAIILCTGYLYAFPFLEDRLRLQSRLTYYPDNLYKATLWLGGGGRRLFYLGVQNQYFSYSMFENEALWACRYIMGTIPGEPKSEAEMRMDADKWVKRRQGLKGYHDEVDFQADFVADLSGAVGYKMEAKKIADMFHKWLNDKDADVASYRDQSFQSPFTGTVSRPLKSGWWRTFDDSTESVVKNYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EUQ1</accession>
    <name>A0ABY7EUQ1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="177" mass="20488" checksum="FEB8E1BDD2E0B97A" modified="2025-10-08" version="1">MYSISTDTFFIIINRISTETFYTNIHSKSTETFYTYKHNTSVATYIVHPPKPSKPTYIVHPKKPSIPTNIVYPQEPYIRTYTVYPQKPFIPTYIIYPQKSSIPTNIVYPQTPSIPTYIVHTQKPFIPTYIVYPQTSSIPTKIVFPPTPSIRTYIVHPQKPSIPTYIVYPQKPSIPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EVY6</accession>
    <name>A0ABY7EVY6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DJC16-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_004115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052448">
        <property type="entry name" value="DnaJ_C16_autophagy_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44303">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44303:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046762088" evidence="1">
        <location>
            <begin position="27"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="30"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR14010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="590" mass="68110" checksum="2677A58C826E8FC2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EWW3</accession>
    <name>A0ABY7EWW3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VAC8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_003847</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46043">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46043:SF13">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="358"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR13742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="638" mass="72784" checksum="C86B68B495A24BC9" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EXN9</accession>
    <name>A0ABY7EXN9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HS12A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_004162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR14057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR14057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="240" mass="27165" checksum="E546F15A4D26B596" modified="2025-10-08" version="1">MRENAIATKGKDKLKFDTAIVKALFKRPIDLLMRHLKSLLAEPKMRSVHTVILVGGFGESPYVQRRIKSEITGVRLILPSEAGLAVLKGAVRFGLSPDIVSSRILKYMYGVSGYRDFDEKKHPEEKKKLLNGEWSVPKCLNVYIRVIDEVEVNQQVIMKSIPTCEITLTSVYRTTQENPEYTTDPGCELLGTIRLECSSAIPLQHQVLETTFMFGDTELLVKKKNMSTGKVAYMDFECFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EY07</accession>
    <name>A0ABY7EY07_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_003944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111020">
        <property type="protein sequence ID" value="WAR13839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43907:SF1">
        <property type="entry name" value="GH18 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43907">
        <property type="entry name" value="SLEI FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR13839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="437" mass="52723" checksum="2BAE6601F558BD81" modified="2025-10-08" version="1">MFVFGFVKHFERVFIAIYMEHLVSNYFAMLHRLIENLILAFILAKLCDKVLPFRIQYVKVLPYVIQYNKVLPYIIQYNKVLPYIIQYDKVLPYVIQYDKVLPYLIQYVKVLPYIIQYDKVLPYIIQYDKYDKVLPYIIQYNKVLPYIIQYDKVLPYIIQYNKVLPYIIQYDKVLPYIIQYDKVLPYIIQYDKVLPYIIQYNKVLPYVIQYDKVLQYKFSMIRSCHTEFSMIMSCHTEIRMIRSCHTEFSMIMSCHTEFRIQITKEILDFLNRKSKSKVFKKNIKSQWRKMKKSFIKRNTCCLTYWGMLQWTQSLDFVVDVVISSICKYMCSIILILMNLISFLGYNEKSQQFFTVSKLTTVRKYTVLIYIMAVNNDFESMALVKDRESTMLYVMTRINGFGKGQRVYNVNVMTRINGFGKGQRIYNVVCHDQNQWLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F2U7</accession>
    <name>A0ABY7F2U7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_030541</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="334"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="701"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR15947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="771" mass="86319" checksum="59B0DB8086D1D896" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F4V8</accession>
    <name>A0ABY7F4V8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR15844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="318" mass="35705" checksum="A997537F7429488D" modified="2025-10-08" version="1" fragment="single">VDGGGYTGDIPLVYVHYRLTDVSLHKCTYYNVSLLQVRDIGKCVRHAPGLNISDWDLKLWLSDLKTLFADPIFNKNNPLAQDAIDQLDMLERDELLIQHSDIAEVLDIKNAFEELSSGLDKRASDIGDVVDDIIAPVKHDATDRAIQDTRELIEWKQDAIDDFNVITVEEALTKEPYYIIRFAVQFAQRDQADVKQQAITKKAGTMTQFMKKDVGTMTEHRDDTSSAGSGKTDLSEPSVDFGKNDIHDEGAKRLTKDAVHESDDISPRDSVETYLSELSVDVGVDIHEEGAKRLSKHEVDESGTNIDYLPCTRSNTQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F506</accession>
    <name>A0ABY7F506_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS4B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_030382</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR15788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121:SF9">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045936851" evidence="5">
        <location>
            <begin position="30"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR15788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="365" mass="40318" checksum="494AD136AC3724AF" modified="2025-10-08" version="1">MAVFTGFQPWCRSYPLMLALRFLSGLGGGGLDTGANADMVSIWDEEGRPYMQAMHASFGAGGIVAPLVIEPFLSEKILENVTNGNTSELVTVYGETNIHSAFLISLAVILTGALPFFYMYFRICCCGISHKMAAKKIDHKRPAKLPVGLKIALCILLCACMMSYCAVEDTFAGFLATFCVDYLQWDKSTSSYATSLYWGAFTVGRFTGIILIRFLRPVQLLCGYLICLILAFIGLFIASITMTEPAVWVFIPAPGFFMSVIFPCIFTWTEESILEVTGKISSMFLISASTGTLLNPLFVGYLMKNIAPISFLYVLLVESFLCFSLFIVIYCLLKVYIKTGSRSQTFEIVIPPPEEMTTLSVQENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F679</accession>
    <name>A0ABY7F679_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111021">
        <property type="protein sequence ID" value="WAR17683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR17683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="87" mass="9876" checksum="087FBF2187901884" modified="2025-10-08" version="1" fragment="single">LPNANTQTFIDMIKGILSRFALPNQVSCDNYTCYASHEFKKFANNLKSDHRNVSVVFKRILSKSLADGQDPIIGIPYHRATPLECEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7F7T7</accession>
    <name>A0ABY7F7T7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein Churchill</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_000100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Churchill family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4240">
        <property type="entry name" value="Transcription activator, Churchill"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038543">
        <property type="entry name" value="Churchill_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009508">
        <property type="entry name" value="Transcrpt_activator_Churchill"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31931">
        <property type="entry name" value="PROTEIN CHURCHILL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31931:SF2">
        <property type="entry name" value="PROTEIN CHURCHILL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06573">
        <property type="entry name" value="Churchill"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR18262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="161" mass="18240" checksum="3C427F3C767B0D0E" modified="2025-10-08" version="1">MFEVYPNDVFQIGLLATFTLKAKHGGMCRSCVKEEYPDRESVCLESGSYMMNYAGCSQCGESSAIVMVNKQTTEDEDGQEVITYQHICQSCSHVIANHEHVFHVEDDYQMCSVSLKAIPDPRSGVLKIEADVDCCITLVWDKIELAELDFFIRLRVLQKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FB52</accession>
    <name>A0ABY7FB52_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_000034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR18196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="72" mass="7758" checksum="06882EAB49EAB520" modified="2025-10-08" version="1">MNQLQQAAIDIALEGHNLLLLGSAARGKTVQITCSTGIACNFYKGNACTIHQFTGISDGRYGPTEKWMLLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FBY6</accession>
    <name>A0ABY7FBY6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_000157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR18319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR18319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="97" mass="10830" checksum="6F33DDBF283847DE" modified="2025-10-08" version="1">MFKKISVQNWHLILPTVLMAMKSNPNTETSGFSPFKMLFGGEMRLPDTLKMVHGTAKSNTEITEESHDIKAKESMLGIGETVLRKIHKPTTGLSKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FF06</accession>
    <name>A0ABY7FF06_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_002000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR20162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="51891" checksum="B0848BB490B46354" modified="2025-10-08" version="1">MELMWSRPELIISSSPMSMYNIIYIIERTQADPRYPGISTTQLKGWVTDTRYEVALTGHCSQVRYRVMAINQFGSSGFSNPVYAPSLSPGPVQNIHLTGKGIYYYEDKNNTAFSEFMTVLKWDNPVGWDDRDIDHYEWNQMMNRSCEYISHDSLPILKKMINQSNHILMTISSVSIGCKFLAQVRAVSKCNTKGPWANLLVDLTNCSSINGYMCQDKPFDPPGKVGNVTLSVTSKTEDEVMNYLLYPNLKLTSPLHVFLHVHWRPPLDLGSHGYVDHYIVRSGKAERQLFPIPPEFIGMPASKKAPNDTVEMIFEVETYSIPYTFGVQVIAVGPSQTITDNQWGLFPMHTMEVSRNDSAIMHFMKEGQVLLDQAGIVIIYVKNTMPVHFVFDDSPMGRVGNTTVDRFAMQWGPLVGPEGNRTITVENGTVIARVTYLSDEAEEESREDFYVFTLPEGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FGD4</accession>
    <name>A0ABY7FGD4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="146" mass="16393" checksum="04B3D41FD80B3B05" modified="2025-10-08" version="1" fragment="single">LQEDASSYGSVFDTSSGSNKLKSNGEYEISKQGRVWCIRDLKTNKLTTLKTITANEVFFESKELLSVDGVFHQLIVHNGKKPKLEIAERSSSSSEDERKPNACDFSHGSKSDDYSEKRTTPNSLPESNEPSSRFQKQPNITRTETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHH8</accession>
    <name>A0ABY7FHH8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PRP39-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_002224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PRP39 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111022">
        <property type="protein sequence ID" value="WAR20386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR20386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="596" mass="69563" checksum="0CAD5ADDD88E90C8" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FHP7</accession>
    <name>A0ABY7FHP7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ALMS motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_015677</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029299">
        <property type="entry name" value="ALMS_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21553:SF36">
        <property type="entry name" value="ALMS1 CENTROSOME AND BASAL BODY-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21553">
        <property type="entry name" value="ALMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15309">
        <property type="entry name" value="ALMS_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ALMS motif" evidence="6">
        <location>
            <begin position="2471"/>
            <end position="2566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="892"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1012"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1138"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1242"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1348"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1633"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1838"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2219"/>
            <end position="2368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2419"/>
            <end position="2457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2024"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="906"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1012"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1154"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1242"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1360"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1411"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1450"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1504"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1532"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1553"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1611"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1666"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1679"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1730"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1776"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1838"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1891"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1910"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1936"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2262"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2305"/>
            <end position="2315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2322"/>
            <end position="2336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2419"/>
            <end position="2439"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR21703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2623" mass="295510" checksum="451CDD0CAC9FD540" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FII5</accession>
    <name>A0ABY7FII5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_015351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR21377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR21377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="243" mass="26967" checksum="678DF72CB772773D" modified="2025-10-08" version="1">MGKNRKKKKKGLSDAGEPMDNERIGELESTFYERIADEAGATLKDASQDLALMKDQTEKYVGEKVEEGKQSLRKTGKQETKKMAKQAEMLQKEIKDSHGKGHGIYIGHSENTHIGDETTYNIGSTRDDTDEDEDDEGYTKDYPHLSPTTSLNESGDTGARPKTSSSAWKNLPNRVSIDKAESVHIGEKNSPDKIFEESNFFLATNKTEISSASTVNISFKQGLKNGIPTDKPEEIKKFAEAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FJ31</accession>
    <name>A0ABY7FJ31_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_016121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IL-17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010345">
        <property type="entry name" value="IL-17_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06083">
        <property type="entry name" value="IL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR22147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="166" mass="19287" checksum="FD5262CEA3FC1602" modified="2025-10-08" version="1">MALHVQPAVLRTHNGCRHMSKKQQRKMEQELWTDFPHWTFFLIPVFRQYATGNPSSVIKNTLSNRSPSEILYGEYGSRCPRMANVDCPVYYVLNHDENRIPENIVHARCSCTDCIRNKTDINGCRPVNVHILVWRRDKKTCDYFRSLEPVPVSCQCATTIHKAKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FN05</accession>
    <name>A0ABY7FN05_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CDC20-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_037274</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF52">
        <property type="entry name" value="PROTEIN CORTEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="4">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR23605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="285" mass="31540" checksum="A748E631BEE22805" modified="2025-10-08" version="1">MIAVALHQSTYVWNAESKECQRIEIYVPDVTSGYYISALSWDTKDGNLAIAENKGRINVCDVEKMATSRQFDAWSEKCPVGVIRWTDYGLISGNRKGAITLHDMRTKHPHMVCLTNGSAREVCGLALSHGTSCLASGGDDGVALAWCPWRQGVLATGGGTSDGHIRLWYAQSGDKLGEAFTRSQVCGLVWSEEYKELVSALGSATPDKNDLILWNMKNSEFDPVARLRHHMARPLHVALSPDHTTIATAGADESLCLWNTFPKRCSQRLWSPWDRSPLNPSSYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FNQ4</accession>
    <name>A0ABY7FNQ4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111023">
        <property type="protein sequence ID" value="WAR22489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045347229" evidence="1">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR22489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="64" mass="6684" checksum="413547B2C66A620F" modified="2025-10-08" version="1" fragment="single">MVRALQVFAFVGLLATVYSACTTDSDCTSVVTCGHGEVATCSLLHGGGVGQGENQCECVHHKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FPD4</accession>
    <name>A0ABY7FPD4_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_036858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="2">
        <location>
            <begin position="131"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR23189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="306" mass="34494" checksum="B00FACBF833EFD1B" modified="2025-10-08" version="1">MCLEKWPRLQSQLDLSKPRLTSHQPVSTRSCVEFDPRRSSDRKLDAEFYRQKMEELKAIFPQTGMTHVAPIPDSAPPAVQEMEVETTPDPILENISAMVFSPGNMPPSVIDDSLAVTIEARTRGQRTNKPWCLLHKGRITSSNSGRVMAAGKSQNHLIAEIINGSSLNKYSNLPVQVKWGQYHEDTARADYIKFKEASGTYLGASCDGIVIDKSMPCDCQKEVEDLLSIPSFYMQSSDSCPALCKTHHYYAQVQGEMAVTGLPWCDFVVWTGAHKNNLFVQRIYFDANFVSDMLRKLKGFYNNFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FSX3</accession>
    <name>A0ABY7FSX3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAHD1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR23918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF68">
        <property type="entry name" value="VWFA AND CACHE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR23918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="842" mass="94437" checksum="61DFC654AEB48BF7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FT06</accession>
    <name>A0ABY7FT06_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_037685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR24016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="71" mass="8104" checksum="843BD2A552CDCD82" modified="2025-10-08" version="1">MNSELHTTWASTVWSAVRCLEVPHGHPQFGLLFAVLKYHMGIHNCNRSKTSDNTQYSPLRSAPFLKESFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FTB0</accession>
    <name>A0ABY7FTB0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-fucose protein O-fucosyltransferase 1</fullName>
            <ecNumber evidence="4">2.4.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peptide-O-fucosyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MAR_037748</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">MELC-2E11</strain>
            <tissue evidence="18">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 65 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.221" evidence="4"/>
    <dbReference type="EMBL" id="CP111024">
        <property type="protein sequence ID" value="WAR24079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd11302">
        <property type="entry name" value="O-FucT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039922">
        <property type="entry name" value="POFUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21420">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21420:SF9">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046998292" description="GDP-fucose protein O-fucosyltransferase 1" evidence="17">
        <location>
            <begin position="21"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WAR24079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="323" mass="36438" checksum="EBA177E6F1A38656" modified="2025-10-08" version="1">MKGNIFLHVVLSGLLLAVSADTEDTEPSIEVDGNGYLIFCLCMGRFGNQAEHFLGGLAFAKAVNRTLILPSWRTYKNIPFTDWFKIEKLAQYHRRILCGTLPPQCGPPDRGPGNPFGPFWDELGVNFDSMKAFTVAYHEPDRWVQRFSPSEYPVVALKGAPASFPMATEHRALQQYMEWSDSIVEQGQRYIQQNFPGRKYVGIHLRNGPDWEKACSHLEGGLSSFMASPQCINPRQIKEHVEETGATVVYVATDKNPLIHEIESHLADLKVSVFHQDPWLPQLDLYILGEADHFIGNCVSSFTSFVARARTVHNKPTSFWAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FUU5</accession>
    <name>A0ABY7FUU5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Y1388-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_010753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989">
        <property type="entry name" value="USP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989:SF3">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR25049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="149" mass="16908" checksum="6A5FD568C92572C0" modified="2025-10-08" version="1">MYSSSSVFYLGNIRKENDKVYLIHTVEINSVLHSTQWYSSPYSFDKEMLLNLLEEEKKKIRHKLEAFAVLLKEAGIDGTVKSIHAETPGEGVLKAVEEIGASLVVLGCRGMGKLRRTFMGSVSDYVLHHAPVPVLICRHHEDEQHKHHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FVJ2</accession>
    <name>A0ABY7FVJ2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TXN4B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DIM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF4">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="123" mass="13971" checksum="9B6AF2FB5C9DE0D8" modified="2025-10-08" version="1">MASYLLPHLQSKQDVDNVIRHTEELVLVLRFGKDEDPVCLQLDHILAKSVDDLGKMAKIYTVDVDKVPVTADHTKFIGTFQSKQDLIDVVEVIFRGAMKGKVMVHSPLDPTTLQKYDLVYKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FW92</accession>
    <name>A0ABY7FW92_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PEG3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_010837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR25133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR25133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="532" mass="61292" checksum="B7CBAD86746B4215" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FX32</accession>
    <name>A0ABY7FX32_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MIC19-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_011911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052632">
        <property type="entry name" value="MICOS_subunit_Mic19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21588">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21588:SF18">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="227" mass="25013" checksum="1A5DCA234759C3EA" modified="2025-10-08" version="1">MGGSQSSANTRTVEVDESGNPILTGNVHRRLQGLPESQEKDVQQGVPEGISVFQHSENHKIKAEEFARAVEEVEAKFIKQTGSPVCQDLQQEVYNCYQEHYKESLRAETITGRNVKEAETITGRNVKEAETITGRNVKEAETITGRNVKGAETITGRNGRNYNRQKCEGAETITGRNVKGAETITGRNVKEAETITGRNVKEAETITGRNVKEAETITGRNVKGQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7FZI9</accession>
    <name>A0ABY7FZI9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Inhibitor of growth protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MAR_012022</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MELC-2E11</strain>
            <tissue evidence="14">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15585">
        <property type="entry name" value="PHD_ING3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042020">
        <property type="entry name" value="ING3_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF103">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="260"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WAR26318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="316" mass="36078" checksum="7AE5C2E11CD115EC" modified="2025-10-08" version="1">MLYLEDYLEMIENLPMEMRERLTEMREMDLQVQNALDGLDERVTSFFKKCTQPNLKLDWRDEQFGKIKKDYYKTLEDADEKVQLANHIYDLDLWKWINHLLRTTELKQEKRLTTEKVLSTLANEIARDSFGPVRKTHSASSSPNISMFNSAPSSTSIPYKIGKLCCDDKGCEQFRPDTGLHKAGVPAVQQTTKAAALLQAQQAQQQAHQQKQQAAVMSALSQQLTAVDPPPSVPAETPNELQIVDENGETVNWQDDPNEPRYCLCNQVSYGEMVGCDNDDCPIEWFHYPCVGLTQAPKGKWYCPQCTAALKRRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G1E6</accession>
    <name>A0ABY7G1E6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MEST-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_012600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR26896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR26896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="103" mass="11556" checksum="221F26615B9EBBD0" modified="2025-10-08" version="1">MIASLGTREYNQLVTEMGYQTIAWIVVVTAATILGRMKSQFSKIIMLDMLGYGFSDKPLDHDYLITEQADIHEALLTSLSISRAHREGERVSERVFGGGYGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G439</accession>
    <name>A0ABY7G439_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NEKL2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_002780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR29212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="157" mass="17320" checksum="ECB40BC716A36C55" modified="2025-10-08" version="1">MPHADLKPKNVLLNYKKGKECVAKLSDFGLGQVKINVDATSSVAGAKITHKSAIPRYSAPEVLSGEILKIPDMMKADIWSLALLLHEVLFDEEPYFDMSYETLLQEVGTKGVTPEGPSGVHIDHTVGVTQKKALTFNPADRPDITYMCQIFKGIYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G5U5</accession>
    <name>A0ABY7G5U5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_014130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111026">
        <property type="protein sequence ID" value="WAR28426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR28426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="139" mass="16246" checksum="AA2D4E11F754F58F" modified="2025-10-08" version="1">MSMEDKRSIEMNRMRITNENGHLKLGFSYEYCFGLTLCKARVKYKLWFQWFWYLPHHLNSNKNKPGKARDTLAVALYVSYGGLMGSRSKIFCIQVYLFGATSSHSCVRYVLKRTVTVNTHMTFCFDICSKSVSHEYQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G6W7</accession>
    <name>A0ABY7G6W7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ZN841-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_012730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111025">
        <property type="protein sequence ID" value="WAR27026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="574"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="631"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="317"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR27026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="762" mass="83346" checksum="C2994320BBD76B00" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G876</accession>
    <name>A0ABY7G876_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein quiver</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_002824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047548782" description="Protein quiver" evidence="3">
        <location>
            <begin position="26"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR29256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="13369" checksum="1D8B2CA016E03CFD" modified="2025-10-08" version="1">MAKSQLVLCILPLFLLVTFAGMSSAIRCYVCDSITNTDCKDPFISAPTQDSCVACGKAKGEVSGAQRVARTCESNSLPDICESDTQFGVDVDACICNGDLCNAATPVSMSTSVLLLPLVIVLLEKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7G9Q5</accession>
    <name>A0ABY7G9Q5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_003314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111027">
        <property type="protein sequence ID" value="WAR29746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR29746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="181" mass="20466" checksum="FE9C58593D914F5E" modified="2025-10-08" version="1">MSTRSKKPPGGNCVMTSMWLLNCVGCKRSLMKNDDDGDDDDDDDDDDDDDDDNDDDDDDDDDDDDDDDDDDDDGDDDDDDDNDDDDDDDDDDDDDDGDGDDDGDDDDDDDDDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDSEDDDDDDDDDDDDDDDDDDDDDDDRDINEDNNNDDNEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GA51</accession>
    <name>A0ABY7GA51_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_032976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR30434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="73" mass="8249" checksum="6236FC97E9025E7B" modified="2025-10-08" version="1">MSEQGTTTQLCKLQHRERDNYNNIFPKDAGVIRSHYYAKSGPASFKLIPKKTALISSNSVMCFLQDVKAKKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GAW2</accession>
    <name>A0ABY7GAW2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RHBL2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_034109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051739">
        <property type="entry name" value="Rhomboid_IM_Serine_Proteases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840:SF2">
        <property type="entry name" value="PROTEIN RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="7">
        <location>
            <begin position="111"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR31567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="300" mass="33473" checksum="42B1D95B52191388" modified="2025-10-08" version="1">MSIGNKIGAKDRECERIMTRPGVLTEKERRAMGGFMANVISNIVPESMKQDFLEHYTCCPPPLFMPIISIVEIVVFIIYAMELKDTKDPVTATSGVPLYSPFIYKPSRRYEAWRYLTYLLIHQGYMHLVGNLIFQLLLGLPLEFVHKFWRVAVVYFCGVIAGSLAHSLTDHSIALAGASGGCYALIGAHLASVVVNWSEMNHECCDGNPIRLLLSAPVRLTLLLLLAGLDTANAVYRRFFDPAGGLFLGIAVMKNINEKPWEKKVGWVTLAAFLIFVSLAIFFNGLYNGYPETDWTPCCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GB72</accession>
    <name>A0ABY7GB72_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_034175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR31633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="70" mass="8173" checksum="177AAF2C757AC687" modified="2025-10-08" version="1" fragment="single">MSQIIMFYVLETKQGIFSQEKLHQKQRLQRHVFKRGSQRTWFACLGGRPEAVCRVAYTHSSQPTLYVGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GBS5</accession>
    <name>A0ABY7GBS5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CAV1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_034394</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <location evidence="3">Caveola</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the caveolin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001612">
        <property type="entry name" value="Caveolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10844">
        <property type="entry name" value="CAVEOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10844:SF19">
        <property type="entry name" value="CAVEOLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01146">
        <property type="entry name" value="Caveolin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR31852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="364" mass="41516" checksum="94679D341D167A28" modified="2025-10-08" version="1">MLRTDSDDDILLRAPKPKAKPKPKQQTRGKHEDNLTNRDPNSLNPHVKITFLNVFGEPERGPKTFEFVWELSGLCFNAMSSCMYKLYGLLCGVCVAIYLGCAFVPVIFSQIWICTPRINLCTLIIDIWCKSCCYILTRSCISPFTRTVGLLLSNKDTMTSTNQPRRANKVAPKEPPPKENRDPHHINDHIKIDFYGVLGEPSTAPQTVDFVWECSEIFFDCFREIVYKFSSLCCGVCIAIYWGLQFVPSLFAAIWFITPFTQCFKIACGGWCKRCCYLWARACIRPCTSACGLIFIHCGDGSYRNRPETPLYEPRKPRPKPQSKPVEPPKSPEIKKVAAVAFTSEFNDYDKEKIARSIKRQLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GC16</accession>
    <name>A0ABY7GC16_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LRAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_033439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR30897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="LRAT" evidence="3">
        <location>
            <begin position="200"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR30897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="397" mass="45927" checksum="DA279C4E42930002" modified="2025-10-08" version="1">MESTGTRPIANMDLNQCEQGQTHKQKTQNFTKQNRSNNAHNVFNMNRVYRVISVKDLSGFSLARRRYAALVRYHVDKVNEGAERKDHSDWLADVRYSSLTVEDHSLFNQGTFWVSGRHDKTNKPYKKIHTTLIYNGFLFLKAGRLTERPGGLAITHSKARSGAKEVCDNTNVVRLRHQLDQVIREANKLIVDVKPKDATQLKRGHHISVPGRKPLFRYRHHAIIVEVKENTNSRKATVVVIHTPNPKHKKGRRIVREEKEYDVNEILIREYTFSKYTLEEVAQNAEQHCNSNCDRRYNLCNMNCEHFCTECAIGIHMSHQVLNAPMVVAKCPKHFLHQKIVRVYAFYVKENGCWNVYIGFALIILVLTVFPFLFMKLTGISRSLYGTHDKTPEQRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GD29</accession>
    <name>A0ABY7GD29_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HMCN1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_033553</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035076">
        <property type="entry name" value="Toxin/TOLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF21">
        <property type="entry name" value="SEMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00087">
        <property type="entry name" value="Toxin_TOLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Snake toxin/toxin-like" evidence="4">
        <location>
            <begin position="271"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR31011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="600" mass="64639" checksum="64E0DD79390E1B69" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7GE36</accession>
    <name>A0ABY7GE36_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_034144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111028">
        <property type="protein sequence ID" value="WAR31602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045268594" description="Chitin-binding type-4 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR31602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="54219" checksum="CB20071C867A868D" modified="2025-10-08" version="1">MGYHVTPATFAVFLLLVFITCCSAHGGMQEPPMRSLAWRYGFDVPINYDWNSLYCGGFSKFQQSGGKCGLCGDPYDGPFENDRGGPYDTGIIVRHYPAGMRQIDVKFELTAYHKGNSLGRHENGTSCIGCGLQETFINCADISIGGTVDNIFVRNDTNSPETDIVIPQTANVTQITDDAPSDSFEAVIRALRGFHQFVDRRFNAPGANVATQDSGMVGTRRGAGDHPGINPDQMNVPRNNLQGAGVNSRRVLPGLQPNRNRVPDLHGFPADQTQNTRNRFRTKSQQVQAGRMPVFSHRNSGFPPRTSHGSALGATSGLARNTQLHNRQRIPNGYTNAVVPPNEFGSQMNRMAWHRGDGRTSPRELVRHNSHLDTRDFSTTDIRQHVPQLSRNVELRQDGFPLLQRRQQQYMVPERENWFPNTPAFVQSRRLRAHSDRLRMRNGQSTPFSLPRRIEVDTINVAQHLLRKYPQLRGRVFLSRRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7D7D1</accession>
    <name>A0ABY7D7D1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_006048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ93577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046329918" evidence="1">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ93577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="130" mass="14421" checksum="79B74106F159740F" modified="2025-10-08" version="1">MELLQVVALVSTLSTIGLQCWHCIADDCSDDPSGNYKATEKLCIAEQACQKVYFEMLEETERGNFIHTSTVRGCSSGCKSRNDFRNCTHQQRTSRGCVRKDCCSDADLCNSANTLQIGWSLSVIIIIFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DA37</accession>
    <name>A0ABY7DA37_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anion exchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_006599</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003024">
        <property type="entry name" value="Na/HCO3_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00834">
        <property type="entry name" value="ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF36">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01232">
        <property type="entry name" value="NAHCO3TRSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="646"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="676"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="733"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="772"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="833"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="879"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="904"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="12">
        <location>
            <begin position="76"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="12">
        <location>
            <begin position="229"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="11">
        <location>
            <begin position="393"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAQ94128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="996" mass="112065" checksum="1E7A823D042DC898" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBF9</accession>
    <name>A0ABY7DBF9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IFI27-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_007094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932">
        <property type="entry name" value="INTERFERON ALPHA-INDUCIBLE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932:SF18">
        <property type="entry name" value="INTERFERON, ALPHA-INDUCIBLE PROTEIN 27-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ94623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="141" mass="13860" checksum="8BD3D4031CE629B3" modified="2025-10-08" version="1">MELYRPHGKNHLTNDDAWSWLKKAALPLVVAGASVVAAPLVLSAAGFGAGGIVAGSLAAKGMSAIAMSNGVGVAAGGFFAACQSAGAVGIAGSTLAGIGVATGTAAFAHNTIHGNNGGTDDDEESENEDEKGSDAFYLINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DBR2</accession>
    <name>A0ABY7DBR2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">M3K1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_006512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111012">
        <property type="protein sequence ID" value="WAQ94041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="142"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ94041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="404" mass="44997" checksum="81BEDB330A90C5B0" modified="2025-10-08" version="1">MQGETGKNETFFVDEKMSVIYSRVRDISASFGDKIKIIEKNPHAVDVVDIHGPKYQQFIDVSGRRQRNENLAVAEQFPDLPTPPVVTDGLFIKPREEDPVQNGWLQEKAPCETFTELLEDEGSFCSIQNETAKESKLEEEELEIGAKLGKGGQGIVLLGKLPETGKLVAIKHVRITKGVEALRREYEIAMILNGHPNIIEVYKAEKKDGHFLTYMEYMKDGAVNKHRWYGEGKEEEGVKHVLREVLKGLRHIHDSGIIHRDIKGDNVLKSGDDIKIADLGSAVCAPRIGNGYGDVVDNTFQGTLHFISKEVVREQRFSTASDIWAVGCLGIELVTGELPWGACKVGDSAALLFKIGNTDTPPPLPPDISESLRNFLNQCLQIDPRDRPSASQLLQDKIFADVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DFZ3</accession>
    <name>A0ABY7DFZ3_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_028888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ96198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="337" mass="38904" checksum="241886B2C2418025" modified="2025-10-08" version="1" fragment="single">RKTSTAPKLQRRKTQSQEKKKRIQKRYINDTLLNLYKSFIDLISKCHTLRPFWVVHKKVDVRKTCLFKLHENVKLRSEKLFRLKIIASPNTNTLIEKNICDVDRYNCAYGQCKECVDRKIPTTNVYTEKLEETDSVETLVEDTLKILKERYIKHVFNIKHQYRELKNMKDNLNESGCTAFSLHTVVVYVKDKTKSYCTISDNTQHGPGAIWAHMQPILKSLKADHPNVKNVQFVSDGPSTQYKSKNNFYLFHRKIIENYGFESATWNFTGTGHGKSSADVGCTVKRTADRMVSNGKDINDATALKNENVRGELKKCSISLQLKDLSLRNPQVACRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DGP1</accession>
    <name>A0ABY7DGP1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">E4F1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_029143</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="594"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="622"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="650"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="678"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="920"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="920"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAQ96453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="952" mass="105803" checksum="DC6C34DBF4071FE7" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJB5</accession>
    <name>A0ABY7DJB5_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CLC4G-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_022157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047312788" evidence="1">
        <location>
            <begin position="20"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="123"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="248" mass="28787" checksum="E884315BBD478FB6" modified="2025-10-08" version="1">MATVISLCLLVLIINCVQSQYHRRDLDICEVAIHKSNCSIQTYVTNTQSDLTTGINSLTERYKKLEHKLSKEMKQLSKRVLRGARKLESLVNEFVDTGKKGSWSRSGQCPEGFVTHDDKWLSCYMMSSFNATWYEAREICTALDSDLVSLNSVKEHFLVSFFIKNNAEYNKAAGWWTSGTYVTKTKQWVWASGLETRPFTFIKWAVNEPNEEHDRELQCVMMYHLDKLLWHDQICSDSYNFVCEKTMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJQ2</accession>
    <name>A0ABY7DJQ2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CHMP6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_029622</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAQ96932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="414" mass="46132" checksum="90136AEE2B3BAFBD" modified="2025-10-08" version="1">MGNLFGKKDQKKPASRVTEQDKAVLIEKDRESARQFLKNGKKEKAKLLLRKKKFGETQIEKMDGQLENLDRMVHDLEFAQIEAEVVKGLQRGNESLKQLNKMFSIETVEKIMDETREAAEYQEEIEALLSGGLSQQDEDDVLSELDDIIKSSLPDVEREGEPELPDVPSGEPAGREHPRKERRQEEAMLASGVVHWQGPWESGPSGTLTHDILEGESPAEDGPIFAHTGDVLLLWADLDTDDGGAVASPYCYHRPFFRHVYISTSNRSLAYLQKLIISTSYKVVAIWGEVHSIDCASLRALQFSDRRAIKAFPVPDLACCMHNSLQVPDYAGSICTGRHTLLVIITDLDGRDGALVFLQCLQQRDKPPYLSLSSARHDVEVPLPTRAHGVVLCAGKGCHPLVVGSCDRFSQHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJS4</accession>
    <name>A0ABY7DJS4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DPOLB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_029823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019843">
        <property type="entry name" value="DNA_pol-X_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF42">
        <property type="entry name" value="DNA POLYMERASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00522">
        <property type="entry name" value="DNA_POLYMERASE_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase X" evidence="2">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="238" mass="26598" checksum="35A1F71A13128462" modified="2025-10-08" version="1">MHKYNVYRKAAGVLAKHPTKIKSGTEAKALDGIGLQIGKKIDEFIQTGQLQKLEKIRASDTNVAINELVKVTGIGPAAAQKFVQDGICTIEEKNSQRRNAGEIAYNGIAEVDKEYTAQVCGSFRRGAKTSGDIDILLTHPTFTSTSKKNPDILKRVVTKLEEISFVTDRLSLGDSKFMGVCKLEDTDTVKHDYRRIDIRLIPKDQYYCVPGEPLPVTCEEDIFDYLDMPFKKPSERNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJY1</accession>
    <name>A0ABY7DJY1_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_030193</name>
        <name evidence="3" type="ORF">MAR_030263</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ97573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ97503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="97" mass="10731" checksum="F641A2BDA282BA85" modified="2025-10-08" version="1">MSKMASADTTTNVLEVGEGKEDNETIDATVNKSTNEKEPEQSPVISSAKAAFGRFWSRSESSEKSVEPTSTAKKSKRRHEALRCHQLHDKLDLHEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DJY9</accession>
    <name>A0ABY7DJY9_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein RACK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_029093</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ96403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="145"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ96403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="318" mass="35217" checksum="03D087688C27BBE0" modified="2025-10-08" version="1">MATEQMTLRATLAGHGGWVTQIATTPQYPDMILSASRDKTLIQWRLTRDETNYGVPHKMLKGHSHFVSDVVMSSDGQFALSGSWDKTLRLWDLSTSKTTRMFMGHTKDVQSVAFSADNRQIVSGSRDKTIKLWNTLGVCKYTIQEEGHTDWVSCVRFSPNTSNPIIVSSSWDKKVKVWNLTNCKLKTNHHGHSGYLNVVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGGIINSLCFSPNRYWLCAATGPSIKIWDLEGKVVVDELRQEVIGTGSKAEPPQCISLAWSADGQTLFAGYTDNLIRVWQVSMAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLE1</accession>
    <name>A0ABY7DLE1_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_022076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ97703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047351737" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="73"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAQ97703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="230" mass="26076" checksum="6222D6C61711A500" modified="2025-10-08" version="1">MTMPVSVKMFMNLFLLAATFLLHVTGDDICEGGKLQIVPDPKDCAGFVICHGTHRFRFSCSSKGPPKVFDPLSKTCVLMGTTYDHSKYPYSCAKYYQCTGGSQPLLRECPYPRLYDPRTYSCRVYMFVKCGARRESKDPCDYKSNQCAGSGCIPCRARFGTCLGKPNGPNAWEDKLWTPHFLICRDERVILQGDCRQGGKLKIFNPFTRRCMPMADIYKMMSQFGRKTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DLU6</accession>
    <name>A0ABY7DLU6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_028665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111013">
        <property type="protein sequence ID" value="WAQ95975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ95975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="151" mass="17600" checksum="233207DBE7FE880D" modified="2025-10-08" version="1" fragment="single">DATFRDNKLGGVYYLTSVHLTGAGKTEPTAGLFIEEYINGTIPFIDREKYAIIPSRTEHGACRPHACKMKEGFEFDLKQSDDRMTMHHYRSARPEWMWPAKIQKELMLKNVFKSWDRTAVEGFKRVRSPEVQQLAHAIRENVYRVKKLLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DMG4</accession>
    <name>A0ABY7DMG4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DHX34-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_023250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056382">
        <property type="entry name" value="DHX34_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF221">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24485">
        <property type="entry name" value="zf-C2H2_DHX34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="166"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="297"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="610"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAQ98877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="975" mass="112003" checksum="94EE595F5A7C3525" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNK2</accession>
    <name>A0ABY7DNK2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_022554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ98181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="144" mass="16334" checksum="56B5BFEF32B38787" modified="2025-10-08" version="1">MTNTFTTACAILKNIIICFNVILKWRDNTCESTYPGQVSQNFHARKELRVLAGQSDLKKAHRVISKFEAGSLSLNNYNIYPVGQKKNRVKQEKGKILLHRKGAAFEGQGSVAQKKCRVLLPRKWQGLLHRKRAEKLKKGAKGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DNR9</accession>
    <name>A0ABY7DNR9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ACH1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_022713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ98340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="84" mass="9566" checksum="27AEC9FF25BB67CF" modified="2025-10-08" version="1">MSLMRQIMLELENIQGLSCYVDIGSNMISMLLTCYSANVDFETKFLITATDMYSGLIIWEPPAIYKSVCIIDVEYVSFDAQNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DP45</accession>
    <name>A0ABY7DP45_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MEG11-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_023837</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045701175" evidence="3">
        <location>
            <begin position="20"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="586"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="701"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAQ99464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="823" mass="89846" checksum="8A9CC3E137BAFFE2" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DQG8</accession>
    <name>A0ABY7DQG8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_022948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ98575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAQ98575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="37" mass="4489" checksum="C30F600E7DB34E5B" modified="2025-10-08" version="1">MKRSAYSHVGGEWMCWRARVYKSVFVRVFVRAYVCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRT4</accession>
    <name>A0ABY7DRT4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">POGK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_023763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF57">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="54"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAQ99390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="244" mass="27718" checksum="2BEBD1DE85E5E6EE" modified="2025-10-08" version="1">MFVIDAWKDHKFELDAICNMDETPIFFDMPSNRTINFKGSKTVSIKTAEGEKTHFTLILSCLADGTKLKPAIIFKRKTIPKEKLNKGVIVFTQEKAWWLNDVWFKRPGALLNKKALIVWDMFHAHIVDVVKPKLGRRMYQSVIPGGCTSVLQPLDVCLNKPFKSNMRIKWNDWMINGTKEGWGHSKANHTNYSWAEIPTEMVIGSFLKCGISNSLDSTEDDKLFNDAVGTGGSRQDSSLVLRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DRZ8</accession>
    <name>A0ABY7DRZ8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_024840</name>
        <name evidence="2" type="ORF">MAR_024850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029375">
        <property type="entry name" value="CFAP141"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35818">
        <property type="entry name" value="C1ORF189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35818:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15104">
        <property type="entry name" value="CFAP141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR00468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR00478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="144" mass="16912" checksum="D9A7BA0EBDC4F49F" modified="2025-10-08" version="1">MAGTQPSYIETPWDRELITYDEIMADRENVVRLHKYNDFWDSLVKDVNTIVLKAEGKADADTEEACDKEKNVNQRAGWNENLEVASWKKRIQNEAEYIKSEIRMAAKASLAVRRVALKQQYERELAQWEKELALQGKTFYKQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DU39</accession>
    <name>A0ABY7DU39_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">KTAP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_024238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KRTCAP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAQ99865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018614">
        <property type="entry name" value="KRTCAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32001">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32001:SF1">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09775">
        <property type="entry name" value="Keratin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAQ99865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="81" mass="8879" checksum="06AB24AC4CDF8DF5" modified="2025-10-08" version="1">MGVSTGPSLMLSGTLVVLCFAGMQMYRVQLASSEYMTILGGFVGSVFIFSMVALYYINKISQTKYQAAVPVQTPKSQKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DU83</accession>
    <name>A0ABY7DU83_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="7">AK6</shortName>
            <ecNumber evidence="7">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="7">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MAR_024588</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MELC-2E11</strain>
            <tissue evidence="8">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer and homodimer. Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="7"/>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="7">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="7">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WAR00216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="175" mass="20082" checksum="ECB83D6418402C6E" modified="2025-10-08" version="1">MENVRPGGPNILITGTPGTGKSTLGAELAQRCSLHYINVGELAKQEQLYDGFDQEYQCPVLSEEQVVDEMENQMTDGGNVVDYHGCDFFPERWFDIIFVLRTDNTVLYNRLEHRGYSGKKLEDNVQCEIFQTILEEARNGYKPELVHELPSNTPEEMEDNLDKIEAWIQQWKAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DV67</accession>
    <name>A0ABY7DV67_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028996">
        <property type="entry name" value="GM2-AP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357:SF0">
        <property type="entry name" value="GANGLIOSIDE GM2 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357">
        <property type="entry name" value="GM2 GANGLIOSIDE ACTIVATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19212" checksum="B84814B331E77A3D" modified="2025-10-08" version="1" fragment="single">TPDTDAVTFHDFQISPDAITFPGQVHLHLNMTFHRVVEHAFIDIEINRMLFGIPIKLPCLDESMVIGSCNNADACHIFNSILRDPNHQTDYGHQAENVFFAAIGHHIQCPIPAENIVVNDGSFTLFAVADFLKLLTSGNYQFKLKAKDSKDGPYNIGCMEVNATVSDSVQPVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWI0</accession>
    <name>A0ABY7DWI0_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_007817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045103">
        <property type="entry name" value="RNF5/RNF185-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12313">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR01259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="90" mass="9651" checksum="79EF9BD548EE3F28" modified="2025-10-08" version="1">MSATAGAEGGGASSDANESENSAYECNICLDTARDAVVSIWPCLHTWLETRPNRKTCPVCKAGISKEQKCLPDRKDRDLNLKHKGSTGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DWZ4</accession>
    <name>A0ABY7DWZ4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_007721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR01163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR01163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="414" mass="45890" checksum="6E9FCC08C9CE1266" modified="2025-10-08" version="1">MEFLFQGFSVLIFFLDKGYSEFTDWTTLLLLKPGSTVSPVDVWSDVSSSYNSDVNMTFSALVASGSQGYRNRPVVDNWASYAPDRVRVSYRNGEGFVLFSAIFNATGSSDTDWLAMSHLVGNHAYSQVTWSTDYISYGVQLAFTDSSWGVERYSAAAVRLPDGTYVYVVPFSGTLDLLPMTLLDVNTKVFDAPLSDGTSITVSEAIEVSFIARQVIYGFNVSVTSPLVSDVSVELVLHFRNEACNGTNLLNKTHQETFIIPPSPGGFITADYLVIETSWEIASGELCECECWVYDLLYGDSPFTNLSYTEIEKALENVTKQIEKELSVNRSELSSTIRKLTSAEDNRTSAVAVGYTLGVAMLTCIFGAIILADLPRIYEGFKTLRHNLRSRFYPETTVNNVSMERIPSLPQPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DX03</accession>
    <name>A0ABY7DX03_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_008806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR02248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="67184" checksum="488D2834A1A1DBD1" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DY19</accession>
    <name>A0ABY7DY19_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RASEF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MAR_008943</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">MELC-2E11</strain>
            <tissue evidence="7">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR02385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="341"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="122"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WAR02385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="646" mass="72878" checksum="8F50EEC0E94FE8A4" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7DZT7</accession>
    <name>A0ABY7DZT7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PKHB2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MAR_024803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">MELC-2E11</strain>
            <tissue evidence="5">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111014">
        <property type="protein sequence ID" value="WAR00431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039680">
        <property type="entry name" value="PLEKHB1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14309">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14309:SF10">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="197"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WAR00431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="383" mass="43028" checksum="40F61F7119191672" modified="2025-10-08" version="1">MADERSARGRDVSGDSGPTLRRQGNFKVVQPLLSSVKMAGLVVAPRSTGKPRKENGYLEPAQVEFMVYLIFGRQTPVGKVFAPVFQTVEEFREPPEGRSGLLGSWNPTMHSSLPVKILIANVFLGAPLMERPDDNDTNNDDDEETGDKDFKGFLLACGLWGFLLLKKCQWLRNRTSWCMRTRGGIGIFKENNRMEKQIVKAGWLQRRSSVVHRWKRCWFVLYRDGNLTRFESPDSRHPEKSLILRAVCVGLRTGAEMRDHNDDLKLCAENMDDMKAWQLTIEEARSTAGAQVPAGSQVFYPQVVSHVYGGYPGQIITQQGQTSDVGPGCPLVKIYVHPKSPPRKVIKASPEHLDTDLPVRPFLDQSDLTSPWGDSPYNPPTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E2S2</accession>
    <name>A0ABY7E2S2_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_019702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR04333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="10789" checksum="C1BB825859D1B81F" modified="2025-10-08" version="1">MMMMMILLLMMIMLMMMMILLLMMMMMMMMMMMMMMMMMMMMMMMMMMMMILLLMILMMMMMMMMMMMMMMMMMMMMMKTPIHYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E4U9</accession>
    <name>A0ABY7E4U9_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S17A5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_010550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP111015">
        <property type="protein sequence ID" value="WAR03992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.540">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027378">
        <property type="entry name" value="Nucleotide_channel_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR03992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="441" mass="47916" checksum="4EA1E86270B0BFF0" modified="2025-10-08" version="1">MKQKVIDGTGYEIVKKKQDDSKDESSHLPTDKVPVNGVCCPSRLILAGMGFWYGVLGYGLSTNMSVAIVCMAKLPNGNASFSRNQTININWTDRIQRVTSVYQIQTNISIANSHLSSCESVDAEQFSSETAEFEWSKKTQSLILSGFFYGYVVTQIPGGWMATRFGGKIVIGLSMALASLFTLMMPMIARASPYAVFVNRIAIGISCKMSSPWRDICTYTPAIAVVVTHACDTCTYYLILTCLPQYLKEVLKFDIQTNGLYSALPWISMLIGVILAGIGADSLRAKGWISVTNVRKLFQVSASIGVAVFLCVPGFLTCDQRGLVIACLCACTMLEGLGFGAGYTCNWVDMSPRFASLLFAVSNTVASIPGIVVPVIVAELTENQTSEDWRVVLVGASVISVLGALVYGMFSSSDLAPWSEHEYDESEVEPTDSKLFLETSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E5I0</accession>
    <name>A0ABY7E5I0_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWDE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_019579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058727">
        <property type="entry name" value="Helical_Vwde"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF51">
        <property type="entry name" value="VON WILLEBRAND FACTOR D AND EGF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26129">
        <property type="entry name" value="Vwde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="VWFD" evidence="3">
        <location>
            <begin position="255"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR04210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="829" mass="92104" checksum="D1D6108C1FCEB88C" modified="2025-10-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E728</accession>
    <name>A0ABY7E728_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR04587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="232" mass="26553" checksum="5302BA6FF1796266" modified="2025-10-08" version="1">MQVSCPLETKKRNDIWMRDMQCSFMLTVSHELPYSPCKYTSATYVYLNVHTISCCCFTGDLKHEFLTAGSVYSTQWGSDDHGWLGLAKMMACCNTMLTSCENHNRQISNQLANYNRQVQRQIEALNKKVDALRTVVDVSTDAQHVATPPTNPNTDHASSNLEDLIAKFGHMTENELLRLHAEVNNVEHVACLLTRKVFPELFGPINLRYMYNWNSGSQKKKRKLDIARKYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E834</accession>
    <name>A0ABY7E834_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SMUG1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MAR_020346</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">MELC-2E11</strain>
            <tissue evidence="6">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039134">
        <property type="entry name" value="SMUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13235">
        <property type="entry name" value="SINGLE-STRAND SELECTIVE MONOFUNCTIONAL URACIL DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13235:SF2">
        <property type="entry name" value="SINGLE-STRAND SELECTIVE MONOFUNCTIONAL URACIL DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WAR04977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="668" mass="75442" checksum="23B10D63B4D0E09D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E902</accession>
    <name>A0ABY7E902_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="102" mass="11329" checksum="C1AFFF96739B75CD" modified="2025-10-08" version="1">MSGSYKGATTLRDKIIDLLQTISLKQQVSPPSGKINVASLLKSCMTSSATCHEIKKEVNHDLSAVVTMKVLKRACQQRFGNFFDKTIQLSFSFLQALPDRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9Q8</accession>
    <name>A0ABY7E9Q8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_020916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR05547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="93" mass="10518" checksum="0FA72614847C077B" modified="2025-10-08" version="1">MNSNDRGLLAKQISRYLTNALELCEEINLNEYPSGDIDRFCSVIGEDGVMTLKLLSANSSELLVKDVVCHMWKMQIRDREGLDPASEPVFEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7E9V6</accession>
    <name>A0ABY7E9V6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HARB1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MAR_020961</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MELC-2E11</strain>
            <tissue evidence="9">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR05592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WAR05592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="198" mass="22557" checksum="313F9DB0F782456B" modified="2025-10-08" version="1" fragment="single">ELSTGHISGFRLRGNMKGIEGDYVNRKGYHSINVQMVCDSSFRFLNVVAKWPGSVHDARIFRESELCQQLEAGALNGYILGDSGYPSKPYLLTPYLATRSQKQERYNRAQVRTRVVIEQSFGILKRRFPCLSYGLRVEPDLCCTIIVACVFLHNFGLSNGDTLDPNDDFNDDQPEVQLNFEGTRNGLLYRDILAEQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EAW6</accession>
    <name>A0ABY7EAW6_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_016948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR06990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR06990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="512" mass="58468" checksum="C4B7358D59E896DF" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBC8</accession>
    <name>A0ABY7EBC8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FCGBP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MAR_019835</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MELC-2E11</strain>
            <tissue evidence="11">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR04466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039:SF58">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039">
        <property type="entry name" value="FIBRILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046840879" evidence="7">
        <location>
            <begin position="22"/>
            <end position="2180"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="134"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="209"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="10">
        <location>
            <begin position="1138"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1325"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1374"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="9">
        <location>
            <begin position="1500"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1817"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1858"/>
            <end position="1897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WAR04466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="2180" mass="235926" checksum="511E600CC9A2124D" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EBK5</accession>
    <name>A0ABY7EBK5_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MAR_021873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">MELC-2E11</strain>
            <tissue evidence="4">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="3">
        <location>
            <begin position="22"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WAR06504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="88" mass="9983" checksum="323C5931DF2940E5" modified="2025-10-08" version="1" fragment="single">MYQDKFSNKIEECDHTQICRTHPCPKLQAPKNGLVACNGWQTEYATMCKYYCYDGFALPPGFTAQHIVNCGATGMWSPSTQLRECILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECD4</accession>
    <name>A0ABY7ECD4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FUCL6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MAR_021433</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">MELC-2E11</strain>
            <tissue evidence="10">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fucolectin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111016">
        <property type="protein sequence ID" value="WAR06064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051941">
        <property type="entry name" value="BG_Antigen-Binding_Lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713:SF15">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713">
        <property type="entry name" value="FTP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045111389" evidence="8">
        <location>
            <begin position="23"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="9">
        <location>
            <begin position="23"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="9">
        <location>
            <begin position="166"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="9">
        <location>
            <begin position="309"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WAR06064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="446" mass="50000" checksum="55D6AD3AC05B9E7B" modified="2025-10-08" version="1">MDTLLFTLNLCVLLVVADYAHGTRNVAIGKTASMSSNHREYKWLAQTAVDGNVGNNSMLSDTCFHTTKEYQPWWRVDLHQDYYITSVVVYNRLDCCANQARKIKLTIGKSLDSMSQAGHLDGGFTTTHTFTVDPPLVGRFVQLQLYGITEFFHLCEVEVMAYPSGTYNVATGKTASQSSNFSTLKYHASTAVDGYAGDNRFASDSFFSTTKEYQPWWRVDLHQDYYITSVVVYNRLDCCANRARNIKLTIGKTLDSMSQAGYLDVLFTTPHTFTIDPPLVGRFVQLQLKGITEIFHLCEVEVMAYPSGTYNVAFGKTASQSSNYNTSKYNATTAVDGNVGDNAFASDSCFCTAKEYQPWWRVDLHQNYYITSVVMHYQLDCCGNQARNIKLTIGKSLDSMSQAGYLDGGFTTHTFTIDPPLVGRFVQLQLKGITEFFHLCEVEVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ECI7</accession>
    <name>A0ABY7ECI7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_017681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR07723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="112" mass="11825" checksum="E59698CCA1640FFE" modified="2025-10-08" version="1">MKTSLHDVILSCHGNPTLTLRNSWSFCLNAKAVFKKDEKLVKHEIPIFVYRQRKQTLNYHFWDPKLNIQNHETLVMGNSGGTCGGGGSNGGCGGGGGYAGGGGSGVAEVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ED10</accession>
    <name>A0ABY7ED10_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="389" mass="43851" checksum="F58C3B037F5A4952" modified="2025-10-08" version="1">MFDASCNFFSVKFRLRAYKSKGKYVNFTYAQIRVPRLTTSGPSKPRMKGVKKVVDDPGKTRPEVPDRTDQGTPRCSKEVLHTRPEIAGKESEQHLQQAPLCNPQQRGETQTALTTSLLPLPINTYPADEFVSDITKLDTLGVHPINASSFPYLLETHHDSSFYAARNCCTADHRLLHTMASVYKDFAGARLFDTSTCARPTVRQLFAPYRTNGPARRRMQHPSPSDEFTTWTHRMGLHLGKKRVLQEAGLGEIKITIPKTNSFIDLRQKLSEFFPKLKEAGGFQLLRSAVGSRNLLEVIRLPPEGYTTQYLADRCGLGQAMIYVRQLQTCLSVSPVKSQSGTKIDPEKKRKKMFVPVQFVECLFQQLILSSMQISVVKMINSKALRQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EDH3</accession>
    <name>A0ABY7EDH3_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MAR_018035</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">MELC-2E11</strain>
            <tissue evidence="13">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the midasin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01460">
        <property type="entry name" value="vWA_midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21108">
        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="12">
        <location>
            <begin position="5177"/>
            <end position="5335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4404"/>
            <end position="4427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4535"/>
            <end position="4589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4603"/>
            <end position="5068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="5372"/>
            <end position="5407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="3143"/>
            <end position="3170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4416"/>
            <end position="4427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4570"/>
            <end position="4589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4609"/>
            <end position="4629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4630"/>
            <end position="4642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4666"/>
            <end position="4690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4691"/>
            <end position="4701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4712"/>
            <end position="4730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4731"/>
            <end position="4755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4757"/>
            <end position="4768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4769"/>
            <end position="4779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4780"/>
            <end position="4790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4803"/>
            <end position="4826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4832"/>
            <end position="4843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4848"/>
            <end position="4859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="4883"/>
            <end position="4911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4918"/>
            <end position="4977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="5011"/>
            <end position="5026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="5053"/>
            <end position="5068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="5372"/>
            <end position="5381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WAR08077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="5407" mass="608804" checksum="CBF0B582D7C6F702" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEJ7</accession>
    <name>A0ABY7EEJ7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BRE4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_017129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR07171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="1">
        <location>
            <begin position="17"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR07171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="179" mass="20809" checksum="BC9481DA28E51077" modified="2025-10-08" version="1">MYNVLRSNVTHDVLRSHVAHKYGNKTFNKGRLMNIGFTEARKHDEFDCFIFHDVDLIPEDDRNMYTCSENPRHMSPAVDKFNYTMLYKSLVGGVLSFRGKHFTKVNASKLSVERPSITIGRYTMIKHDRKDVSKVRLGLLKTSITRYLKDGLNTLEYKMVETRLEKLYTRMIADVGDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EEW6</accession>
    <name>A0ABY7EEW6_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_018521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-4" evidence="2">
        <location>
            <begin position="147"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR08563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="351" mass="39470" checksum="666EECC9E0CCA9A4" modified="2025-10-08" version="1">MKDRKEEKNQSIKKKKRAERVGKHPSPRAWAKTFGHLIKKVTPRRRSKLLGESSDKGKENCESVLNLKLEDQEKKCRMLISRILPFLVLSASERTLVYIWVCQDRCKHSMVQMQYILQTNILSNMDMKYLVTIVLLCIVTLGHVSGHGRLTDPPGRSSAWRFGFKTPINYNDNSLECGGFPYQYSPEVNGRCGACGDPYFGPFNNEAGGRYAQGVLVRNYTEGQTIRVTLDITANHGGYSEFRICANNDVSKRVTQECLNEHLLKTPSGESRYLHENGNAGKGIKHVDLILPYGLTCTQCVFQWKWKTNSGNNCGRTAGCCDPSNIGCGPQDEFRGCADVSIVPYLYILGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2025-10-08" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGH8</accession>
    <name>A0ABY7EGH8_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MAR_018000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">MELC-2E11</strain>
            <tissue evidence="1">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WAR08042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="58" mass="6235" checksum="4DD3295E1A5C9235" modified="2025-10-08" version="1">MKILKSDCLLLDVGSFLKEKGDQTGRKLGKWLSTNSPSAWLIRGATALNITAQSGVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EGY2</accession>
    <name>A0ABY7EGY2_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PSTA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_019078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR09120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WAR09120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="594" mass="60967" checksum="02A4425F6B8A956E" modified="2025-10-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EHE7</accession>
    <name>A0ABY7EHE7_MYAAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MAR_018184</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">MELC-2E11</strain>
            <tissue evidence="12">Siphon/mantle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP111017">
        <property type="protein sequence ID" value="WAR08226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein eS4 N-terminal" evidence="10">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein eS4 central region" evidence="8">
        <location>
            <begin position="101"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein eS4 C-terminal" evidence="11">
        <location>
            <begin position="192"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WAR08226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="241" mass="27031" checksum="538469EC7F902A94" modified="2025-10-08" version="1">MLAPGYRGRRKHLKRLTAPKAWMLDKLGGVFAPKPGTGPHRSRECLPLVVFLRNRLKYALTADEVKKIVKQRLIKIDGKVRTETRYPAGFMGKNIETILLYKLCRIRKQENGPKGVPYVTTTDGRTIRYPDPLIKVNDTAMVDIASGKIKDFIKFDSGNLCMITGGHNLGRVGVIQHRDRHPGSFDIVTVKDAVGHTFATRIGYVFVIGKGSKPWVSLPRGKGVKLTIAEERDRRMAIKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7ELT7</accession>
    <name>A0ABY7ELT7_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FMR1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MAR_035861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MELC-2E11</strain>
            <tissue evidence="3">Siphon/mantle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP111018">
        <property type="protein sequence ID" value="WAR10785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001164746">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040148">
        <property type="entry name" value="FMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603">
        <property type="entry name" value="FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603:SF7">
        <property type="entry name" value="FRAGILE X MESSENGER RIBONUCLEOPROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="63"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WAR10785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001164746"/>
        </source>
    </evidence>
    <sequence length="169" mass="19064" checksum="A13468EB972A10E5" modified="2025-10-08" version="1">MFCLKDNNEALNSLFDILKDVCSIEEEVDGSDDGSTVTHVGGIAASDKHKTEEVCKRAREMLEYAEETYQVPMDLVARVIGMKGKNIQDIVDKSGILRVKIDGAKKGDESRQDWLHRHATFTFVGTVMNISNAQMLLEYSIDHLRDQHFTEPERVAVVKNLTSPIIRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABY7EMB4</accession>
    <name>A0ABY7EMB4_MYAAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MAR_035436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mya arenaria</name>
        <name type="common">Soft-shell clam</name>
        <dbReference type="NCBI Taxonomy" id="6604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Bivalvia</taxon>
            <taxon>Autobranchia</taxon>
            <taxon>Heteroconchia</taxon>
            <taxon>Euheterodonta</taxon>
            <taxon>Imparidentia</taxon>
            <taxon>Neoheterodontei</taxon>
            <taxon>Myida</taxon>
            <taxon>Myoidea</taxon>
            <taxon>Myidae</taxon>
            <taxon>Mya</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="EMBL/GenBank/DDBJ databases">
            <title>Centuries of genome instability and evolution in soft-shell clam transmissible cancer (bioRxiv).</title>
            <authorList>
                <person name="Hart S.F.M."/>
                <person name="Yonemitsu M.A."/>
                <person name="Giersch R.M."/>
                <person name="Beal B.F."/>
                <person name="Arriagada G."/>
                <person name="Davis B.W."/>
                <person name="Ostrander E.A."/>
                <person name="Goff S.P."/>
                <person name="Metzger M.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">MELC-2E11</strain>
            <tissue evidence="2">Siphon/mantle</tissue>
        </source>
 